GO ID |
Ontology |
GO Term |
Term Definition |
Proteins |
GO:0000010
|
MF
|
trans-hexaprenyltranstransferase activity
|
Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate.
|
PDSS1,
PDSS2
|
GO:0000014
|
MF
|
single-stranded DNA endodeoxyribonuclease activity
|
Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.
|
ERCC1,
MRE11A,
RAD50,
ERCC4,
DCLRE1C
|
GO:0000016
|
MF
|
lactase activity
|
Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose.
|
LCT
|
GO:0000026
|
MF
|
alpha-1,2-mannosyltransferase activity
|
Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage.
|
ALG9
|
GO:0000030
|
MF
|
mannosyltransferase activity
|
Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
|
DPY19L2,
DPY19L3,
DPY19L4,
ALG9,
POMT1
|
GO:0000033
|
MF
|
alpha-1,3-mannosyltransferase activity
|
Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.
|
ALG8
|
GO:0000036
|
MF
|
ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process
|
Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis.
|
NDUFAB1
|
GO:0000049
|
MF
|
tRNA binding
|
Interacting selectively and non-covalently with transfer RNA.
|
PTCD1,
TRMU,
FARS2,
SSB,
RPL35A,
RARS,
YARS,
EEF1A1,
NSUN2,
IFIT5,
KARS,
EARS2,
TRMT1L,
TRNT1,
THUMPD3,
SEPSECS,
EIF2AK4,
FARSA
|
GO:0000062
|
MF
|
fatty-acyl-CoA binding
|
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
|
ACOT7,
ACOX3,
ECI2,
SCP2,
SOAT1,
HMGCL,
ACADSB,
ACADVL,
ALDH6A1,
ACOX1,
ACBD5,
ACOX2,
ACBD3
|
GO:0000064
|
MF
|
L-ornithine transmembrane transporter activity
|
Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid.
|
SLC25A15
|
GO:0000095
|
MF
|
S-adenosyl-L-methionine transmembrane transporter activity
|
Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.
|
SLC25A26
|
GO:0000104
|
MF
|
succinate dehydrogenase activity
|
Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor.
|
SDHB,
SDHA,
SDHC
|
GO:0000146
|
MF
|
microfilament motor activity
|
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
|
MYO1C,
MYO1D,
MYH9,
MYO1E,
MYO9B,
MYH2,
MYO5B,
MYO5A,
MYH4
|
GO:0000149
|
MF
|
SNARE binding
|
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
|
GOSR2,
STX7,
EXOC3,
VAMP4,
SEC22B,
STX11,
SNAPIN,
SYT1,
STX2,
VAMP7,
GABARAPL2,
STXBP1,
VAMP2,
TNFAIP2,
STX4,
STX3,
VAMP3,
SEC22A,
ANKRD27,
TRIM9,
CAPN10,
VTI1B
|
GO:0000150
|
MF
|
recombinase activity
|
Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
|
RAD51C,
RAD51D,
RAD51
|
GO:0000155
|
MF
|
phosphorelay sensor kinase activity
|
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
|
KCNH2
|
GO:0000166
|
MF
|
nucleotide binding
|
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
|
RBM47,
IGF2BP3,
HNRNPDL,
U2SURP,
SYNJ2,
POLR2D,
RBFOX2,
HNRNPR,
SYNJ1,
ORC5,
SYNCRIP,
REV3L,
SRSF10,
CRCP,
DHRS3,
DXO,
TMEM63A,
SCAF4,
CELF2,
PARN,
CNOT4,
PTBP3,
TYMS,
SSB,
HSP90AA1,
HNRNPC,
SNRPA,
HNRNPA1,
POLA1,
PYGM,
HNRNPL,
NT5E,
HNRNPA2B1,
SFPQ,
EIF4B,
PTBP1,
POLD1,
RBMS1,
TIA1,
HNRNPH3,
HNRNPH1,
FUS,
RBMX,
MATR3,
VDAC2,
RBM25,
HINT1,
FHIT,
HDGF,
HNRNPA3,
HNRNPM,
RBM5,
RCAN1,
HNRNPH2,
EIF3B,
RPL23A,
TRA2B,
RBM6,
GPSM2,
RBM3,
SRSF2,
EWSR1,
SRSF11,
POLE,
SRSF1,
GRSF1,
TARDBP,
SRSF9,
SRSF5,
SRSF6,
TRA2A,
CIRBP,
HNRNPD,
RBM39,
ELAVL3,
ZNF638,
SART3,
NONO,
RNPS1,
RBMS2,
ELAVL1,
CRY1,
MRPL23,
SNRNP35,
CPEB4,
LARP7,
PABPC1L,
NCBP3,
RBM48,
RBM26,
SLC27A4,
SLC27A1,
RBPMS2,
RBM43,
LARP4,
NOL8,
CPEB2,
PABPN1,
ALYREF,
CHD1L,
PPARGC1B,
RBM45,
TNRC6A,
CPEB3,
NUP35,
ZCRB1,
ENOX1,
PPIL4,
SREK1,
PSPC1,
TAF15,
RBPMS,
MSI2,
DAZAP1,
RBM33,
RBM17,
RNPC3,
RBM15,
SPEN,
HNRNPAB,
CDC6,
RBM4B,
LARP6,
RBM4,
RBM24,
HINT2,
POLDIP3,
NIFK,
SLIRP,
RBM38,
UPF3A,
PABPC3,
ESRP2,
TNRC6C,
RAVER2,
NOX4,
HINT3,
PRTFDC1,
RBM22,
RBFOX1,
SLTM,
TRNAU1AP,
AKAP7,
MYEF2,
PPARGC1A,
NXF1,
PUF60,
PTBP2,
G3BP2,
PPIE,
SCAF8,
TNRC6B,
VDAC3,
SLC27A6,
LEMD3,
RBMX2,
RRP7A,
SF3B6,
R3HCC1,
KIAA0430,
RBM8A,
IGF2BP2
|
GO:0000171
|
MF
|
ribonuclease MRP activity
|
Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.
|
POP4
|
GO:0000175
|
MF
|
3'-5'-exoribonuclease activity
|
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
|
EXOSC9,
EXOSC2,
EXOSC7,
PNPT1,
ISG20,
EXOSC4,
EXOSC3,
CNOT7,
DIS3,
REXO2
|
GO:0000179
|
MF
|
rRNA (adenine-N6,N6-)-dimethyltransferase activity
|
Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor.
|
DIMT1
|
GO:0000182
|
MF
|
rDNA binding
|
Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA.
|
H2AFY,
TSPYL2
|
GO:0000213
|
MF
|
tRNA-intron endonuclease activity
|
Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
|
TSEN15
|
GO:0000215
|
MF
|
tRNA 2'-phosphotransferase activity
|
Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate.
|
TRPT1
|
GO:0000246
|
MF
|
delta24(24-1) sterol reductase activity
|
Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH.
|
DHCR24
|
GO:0000247
|
MF
|
C-8 sterol isomerase activity
|
Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols.
|
EBP
|
GO:0000248
|
MF
|
C-5 sterol desaturase activity
|
Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.
|
FADS1,
SC5D
|
GO:0000250
|
MF
|
lanosterol synthase activity
|
Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.
|
LSS
|
GO:0000252
|
MF
|
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
|
Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.
|
NSDHL
|
GO:0000253
|
MF
|
3-keto sterol reductase activity
|
Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+).
|
HSD17B7,
DHRS4
|
GO:0000254
|
MF
|
C-4 methylsterol oxidase activity
|
Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O.
|
CH25H,
MSMO1
|
GO:0000285
|
MF
|
1-phosphatidylinositol-3-phosphate 5-kinase activity
|
Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+).
|
PIP5K1B,
PIKFYVE
|
GO:0000287
|
MF
|
magnesium ion binding
|
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
CIB4,
ILVBL,
GTPBP10,
EYA2,
PDXK,
MAP2K7,
MAST4,
MAP3K7,
ATP8B1,
IDH3B,
OPA1,
ATP9A,
ERN1,
RPS6KA5,
PPM1B,
IDH1,
DXO,
FARS2,
TDP2,
LATS1,
NUDT3,
ENO1,
ENO2,
NUDT7,
TOP2A,
PRPS2,
ENO3,
MTHFD2,
PKM,
NME1,
COMT,
S100P,
IMPA1,
WEE1,
ADSS,
DUT,
PCK1,
HMGCL,
PGM1,
SNCA,
FEN1,
MAP3K8,
ABL2,
MSH2,
GCLC,
IDH2,
INPP1,
PAPOLA,
MSH6,
ADPRH,
GEM,
SIK1,
PTEN,
PRPS1,
NCS1,
GNAI1,
SRPK2,
ARF1,
STK4,
ITPK1,
STK38,
RPS6KA2,
RPS6KA1,
STK11,
CDC42BPA,
MAST2,
ENOSF1,
CLYBL,
ADSSL1,
XXYLT1,
ATP8B4,
DYRK2,
NUDT16,
PGM2,
SRPK1,
MAP3K5,
TREX2,
PINK1,
SIK2,
PPA2,
WNK1,
MTG2,
PIF1,
DCTPP1,
RRAGC,
NEK6,
PRTFDC1,
AASDHPPT,
MTPAP,
SPHK1,
ZAK,
MARK1,
NLK,
NUDT5,
ATP11B,
STK38L,
SIK3,
FAN1,
CDC42BPB,
IRAK3
|
GO:0000293
|
MF
|
ferric-chelate reductase activity
|
Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+).
|
CYBRD1
|
GO:0000295
|
MF
|
adenine nucleotide transmembrane transporter activity
|
Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other.
|
SLC25A17
|
GO:0000298
|
MF
|
endopolyphosphatase activity
|
Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues.
|
NUDT3,
NUDT10,
NUDT11
|
GO:0000309
|
MF
|
nicotinamide-nucleotide adenylyltransferase activity
|
Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+.
|
NMNAT3
|
GO:0000339
|
MF
|
RNA cap binding
|
Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.
|
EIF4G3,
EIF4E2,
EIF4E,
EIF4A1,
NCBP1,
LARP1
|
GO:0000340
|
MF
|
RNA 7-methylguanosine cap binding
|
Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
|
NCBP3,
AGO2
|
GO:0000384
|
MF
|
first spliceosomal transesterification activity
|
Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon.
|
RBMX2
|
GO:0000386
|
MF
|
second spliceosomal transesterification activity
|
Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
|
PRPF18
|
GO:0000400
|
MF
|
four-way junction DNA binding
|
Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
|
HMGB3,
RAD51C,
RAD51D,
HMGB1,
YY1,
HMGB2,
MSH2,
MSH6,
RAD51
|
GO:0000403
|
MF
|
Y-form DNA binding
|
Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end.
|
MSH2,
RAD18
|
GO:0000404
|
MF
|
heteroduplex DNA loop binding
|
Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration.
|
MSH2,
XPC
|
GO:0000405
|
MF
|
bubble DNA binding
|
Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA.
|
RECQL4,
HMGB1,
BLM,
XPC,
NEIL3
|
GO:0000406
|
MF
|
double-strand/single-strand DNA junction binding
|
Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA.
|
MSH2
|
GO:0000701
|
MF
|
purine-specific mismatch base pair DNA N-glycosylase activity
|
Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
|
PCNA
|
GO:0000703
|
MF
|
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
|
Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
|
NTHL1,
SMUG1
|
GO:0000773
|
MF
|
phosphatidyl-N-methylethanolamine N-methyltransferase activity
|
Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine.
|
PEMT
|
GO:0000774
|
MF
|
adenyl-nucleotide exchange factor activity
|
Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
|
BAG2,
PFN1,
HSPH1,
GRPEL1,
BAG5
|
GO:0000822
|
MF
|
inositol hexakisphosphate binding
|
Interacting selectively and non-covalently with inositol hexakisphosphate.
|
ITPR3
|
GO:0000827
|
MF
|
inositol-1,3,4,5,6-pentakisphosphate kinase activity
|
Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown.
|
PPIP5K1,
IP6K2
|
GO:0000828
|
MF
|
inositol hexakisphosphate kinase activity
|
Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown.
|
PPIP5K1,
IP6K2
|
GO:0000829
|
MF
|
inositol heptakisphosphate kinase activity
|
Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown.
|
PPIP5K1,
IP6K2
|
GO:0000832
|
MF
|
inositol hexakisphosphate 5-kinase activity
|
Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.
|
PPIP5K1,
IP6K2
|
GO:0000900
|
MF
|
translation repressor activity, nucleic acid binding
|
Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
|
PURA,
CPEB4,
CPEB2,
CPEB3
|
GO:0000975
|
MF
|
regulatory region DNA binding
|
Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair.
|
IRF6,
NFKB1,
HMGA2,
RUNX1
|
GO:0000976
|
MF
|
transcription regulatory region sequence-specific DNA binding
|
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
ARNTL,
NR5A2,
SOX12,
PARK2,
THRA,
EGR1,
ATF3,
ATF6,
NFKB1,
SFPQ,
DDIT3,
POU5F1,
SOX4,
HDAC1,
NFE2L1,
NONO,
JMJD1C,
ZNF658,
PSPC1,
PITX2,
SUV39H2,
NFE2L3
|
GO:0000977
|
MF
|
RNA polymerase II regulatory region sequence-specific DNA binding
|
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
ACTN4,
H2AFY,
ZBED1,
ZFY,
GLI3,
NME1,
ZFX,
TAL1,
CEBPB,
EGR1,
ATF1,
ATF3,
ATF4,
ATF6,
NFKB1,
NR1D1,
HNF1A,
LMO2,
RXRB,
RORA,
ETV5,
BCL6,
GATA4,
NKX2-1,
PRDM15,
FOXK1,
ZBED6,
RUNX1,
RELB,
SATB1,
MEF2A,
SP3,
RELA,
MEF2C,
DLX2,
FOXC1,
ZNF211,
RUNX3,
CUX1,
MEF2D,
POU6F1,
ARID5B,
ZMYND11,
HLF,
NFIL3,
NFXL1,
ZSCAN2,
GATAD2A,
AEBP1,
ZNF548,
KAT2B,
GATA6,
ZBED6CL,
ZNF419,
HES6,
PURB,
PHF12,
MNT,
ARID3A,
IKZF5,
ZNF552,
ZNF586,
H2AFY2,
ZBTB4,
MLX,
TRPS1,
ELF5,
PLAGL1
|
GO:0000978
|
MF
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding
|
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
|
E2F8,
MEIS1,
NR5A2,
NFIB,
FOXP2,
PER1,
KDM6A,
ZNF264,
HOXA2,
SMAD6,
MITF,
ZNF253,
ZNF217,
NFAT5,
ZBTB7A,
MBD3,
ACTL6A,
FOS,
MYC,
ESR1,
NR3C1,
JUN,
PGR,
HNRNPC,
NFIC,
H2AFZ,
GLI2,
GLI3,
MYBL1,
MYBL2,
AR,
IRF1,
EGR2,
ESRRA,
SKI,
SKIL,
ETS2,
FOSL1,
FOSL2,
TCF4,
TCF3,
MUC1,
CREB1,
GCFC2,
JUNB,
JUND,
CEBPB,
ATF3,
ATF4,
ELK1,
NR1D1,
MZF1,
HOXA10,
OTX2,
DDIT3,
SREBF1,
PBX1,
STAT3,
ELK3,
RFX2,
RFX5,
CEBPD,
MEOX1,
ETV1,
ASCL1,
SMARCA4,
ZNF138,
FOSB,
NR1H2,
DLX5,
FOXL2,
ACTB,
YBX1,
ELF3,
SMAD3,
TFAM,
HSF1,
INSM1,
MEF2A,
HHEX,
CEBPZ,
ZNF85,
ZNF117,
ZNF92,
RELA,
MXD1,
MEF2C,
GABPA,
PAX8,
PPARA,
RBBP4,
SREBF2,
NFATC2,
SMAD4,
HDAC1,
RUNX2,
NFYC,
ZNF273,
MEF2D,
CHD4,
MTF1,
NFATC4,
NCOA2,
SMAD2,
SMAD1,
ZIC1,
ZNF141,
IFI16,
ZNF506,
PLAG1,
ZNF562,
AKNA,
CTCFL,
SMARCC2,
ZNF502,
ZNF675,
JDP2,
NR4A3,
HDAC2,
SMARCC1,
ZNF486,
TCF12,
PITX2,
BCL11A,
ZNF430,
ZNF395,
EBF2,
PATZ1,
TCF7L2,
ZNF331,
EHF,
GRHL1,
ZNF492,
CHD7,
ZNF639,
ZNF148,
KLF13,
NFE2L3,
PAXBP1,
MAFB
|
GO:0000979
|
MF
|
RNA polymerase II core promoter sequence-specific DNA binding
|
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery.
|
H2AFY,
FOS,
H2AFZ,
TAL1,
CEBPB,
NR4A2,
YAP1,
STAT5B,
MAZ,
SOX8,
H3F3A,
HSF1,
SP3,
PAX8,
EP300,
RUNX2,
MTF1,
SUZ12,
SMAD1,
EZH2,
NFIL3,
NLRC5,
GATA6,
WBP2,
SMAD5,
ZNF335,
SMYD3,
HEYL,
ZNF277,
RUVBL2
|
GO:0000980
|
MF
|
RNA polymerase II distal enhancer sequence-specific DNA binding
|
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
NR5A2,
BACH1,
PAX4,
NFATC1,
MBD3,
ACTL6A,
JUN,
HNRNPC,
HOXB5,
H2AFZ,
HIVEP1,
CREB1,
TAL1,
NFKB1,
SFPQ,
SMARCA4,
ACTB,
H3F3A,
RELA,
REL,
ZBTB16,
MEF2C,
RBBP4,
HDAC1,
NFE2L1,
CHD4,
NONO,
SMARCC2,
HDAC2,
SMARCC1,
MED12,
NR1H4,
BACH2,
RUVBL2
|
GO:0000981
|
MF
|
RNA polymerase II transcription factor activity, sequence-specific DNA binding
|
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
|
NFIB,
BHLHE40,
FOXP2,
SOX15,
ZMYM6,
TP53,
JUN,
ETS1,
JUNB,
JUND,
TAL1,
XBP1,
ATF4,
LMO2,
PHB,
BMPR1A,
ERF,
FOXG1,
SOX8,
FOXL2,
GTF2I,
ELF3,
SIM1,
FOXK1,
FOXO4,
RELB,
POU5F1,
MEF2A,
SP3,
MEF2C,
FOXM1,
FOXO1,
FOXC1,
RUNX3,
RUNX2,
TFDP1,
SIM2,
ZMYM3,
MEF2D,
PCBP1,
TWIST1,
QRICH1,
ZBED5,
ZNF518A,
EPM2AIP1,
FOXP4,
ZBED8,
KIAA1958,
BHLHE22,
ZSCAN18,
GATA6,
ZNF274,
ZNF641,
CDC5L,
EPAS1,
FOXP3,
ZNF518B,
PEG3,
FOXP1,
ZMYM2,
ZMYM5,
ELF5,
FOXJ3,
HIF3A
|
GO:0000982
|
MF
|
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
|
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.
|
ARNTL,
FOS,
JUN,
ETS1,
FOSL1,
FOSL2,
ATF3,
FOSB,
ARNTL2,
JDP2
|
GO:0000983
|
MF
|
transcription factor activity, RNA polymerase II core promoter sequence-specific
|
Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
|
SMAD3,
RELA,
MEF2C,
HEYL,
HEY1
|
GO:0000987
|
MF
|
core promoter proximal region sequence-specific DNA binding
|
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon.
|
KLF4,
SMAD3,
SP3,
SMAD4,
CREBBP,
UHRF1
|
GO:0000988
|
MF
|
transcription factor activity, protein binding
|
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
|
SMAD3,
SMAD4,
HEYL,
HEY1
|
GO:0000989
|
MF
|
transcription factor activity, transcription factor binding
|
Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
|
PER1,
ASCL1,
HMGA2,
FOXO1,
CRY1,
HIF1A
|
GO:0000991
|
MF
|
transcription factor activity, core RNA polymerase II binding
|
Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
|
GTF2F2
|
GO:0000993
|
MF
|
RNA polymerase II core binding
|
Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
|
BRD4,
IKBKAP,
ELOF1,
ZNF326,
CCAR2,
ELP4,
WAC,
SMYD3,
ELP3,
AGO2
|
GO:0001010
|
MF
|
transcription factor activity, sequence-specific DNA binding transcription factor recruiting
|
The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions.
|
KLF4
|
GO:0001011
|
MF
|
transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting
|
Interacting selectively and non-covalently with a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC).
|
TCF4
|
GO:0001012
|
MF
|
RNA polymerase II regulatory region DNA binding
|
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
NKX2-1,
NCOA1
|
GO:0001025
|
MF
|
RNA polymerase III transcription factor binding
|
Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III.
|
HDAC4,
HDAC5
|
GO:0001042
|
MF
|
RNA polymerase I core binding
|
Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.
|
ERBB2,
SPTY2D1
|
GO:0001046
|
MF
|
core promoter sequence-specific DNA binding
|
Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
|
CHD2,
H2AFY,
ESR1,
TP53,
TOP1,
ATF4,
NR1D1,
RORA,
PPARG,
SOX9,
NRIP1,
MEOX1,
CREM,
MEF2C,
SOX4,
KLF10,
MTA1,
NR1D2,
ZFHX3,
CRY1,
NR4A3,
ESR2,
PROX1,
THRAP3
|
GO:0001047
|
MF
|
core promoter binding
|
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
E2F8,
ARNTL,
KLF4,
FOXO3,
RB1,
XBP1,
ELK1,
SFPQ,
GADD45A,
RBMX,
NKX2-1,
NOTCH1,
HMGA2,
HDAC4,
GTF2B,
HNRNPU,
IRF9,
E2F1,
INSM1,
RUNX1,
RELB,
EP300,
MTA1,
HDAC1,
E2F2,
MTF1,
NONO,
EZH2,
CRY1,
IFI16,
CCAR1,
PSPC1,
HDAC2,
NPAS2,
MYBBP1A,
FOXP3,
DHX36,
HDAC6,
AGO2,
HDAC5
|
GO:0001054
|
MF
|
RNA polymerase I activity
|
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
|
POLR1C,
POLR1A,
POLR2E,
POLR2K,
POLR2L,
POLR1E,
ZNRD1,
POLR1D
|
GO:0001055
|
MF
|
RNA polymerase II activity
|
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
|
POLR2E,
POLR2A,
POLR2B,
POLR2J,
POLR2K,
POLR2L,
POLR2J2
|
GO:0001056
|
MF
|
RNA polymerase III activity
|
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
|
POLR1C,
POLR3G,
CRCP,
POLR2E,
POLR2K,
POLR2L,
POLR3GL,
POLR3C,
POLR3F,
POLR3B,
POLR1D,
POLR3K
|
GO:0001069
|
MF
|
regulatory region RNA binding
|
Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
|
MBNL1
|
GO:0001071
|
MF
|
nucleic acid binding transcription factor activity
|
Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
|
SOX4
|
GO:0001075
|
MF
|
transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
|
Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter.
|
TAF9B,
DACH1
|
GO:0001076
|
MF
|
transcription factor activity, RNA polymerase II transcription factor binding
|
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
|
ATF4,
GATA4,
YAP1,
LHX2,
SMAD4,
HIF1A
|
GO:0001077
|
MF
|
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
|
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
|
MEIS1,
NR5A2,
NFIB,
PLSCR1,
SOX12,
KLF4,
TCF21,
MITF,
NFAT5,
FOS,
MYC,
ESR1,
NR3C1,
JUN,
PGR,
NFIC,
GLI2,
GLI3,
MYBL1,
MYBL2,
AR,
IRF1,
EGR2,
ESRRA,
FOSL1,
TCF4,
CREB1,
JUNB,
CEBPB,
EGR1,
ATF4,
ELK1,
WT1,
HNF1A,
NR4A1,
MZF1,
HOXA10,
OTX2,
DDIT3,
SREBF1,
PBX1,
STAT3,
ELK3,
NR4A2,
SOX9,
CEBPD,
MEOX1,
ETV1,
STAT5B,
HMGA2,
FOSB,
CEBPG,
NR1H2,
DLX5,
FOXL2,
YBX1,
ELF3,
TFAM,
MEF2A,
CEBPZ,
RELA,
MEF2C,
GABPA,
PAX8,
SOX4,
PPARA,
NFATC2,
SMAD4,
RUNX2,
NFYC,
MEF2D,
MTF1,
SMAD2,
SMAD1,
ZIC1,
HLF,
HIF1A,
PLAG1,
AKNA,
CTCFL,
NR4A3,
CREB3L1,
NR1H4,
TCF12,
MEIS3,
PITX2,
EPAS1,
NUCKS1,
EBF2,
PATZ1,
HEYL,
EHF,
GRHL1,
ZNF639,
KLF15,
KLF13,
MAFB,
CAMTA1
|
GO:0001078
|
MF
|
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
|
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
E2F8,
BHLHE40,
BACH1,
FOXP2,
HOXA2,
SNAI2,
TCF21,
ZNF217,
ZBTB7A,
ESRRA,
SKI,
SKIL,
ETS2,
TCF3,
GCFC2,
ATF3,
NR1D1,
YY1,
MZF1,
ASCL1,
HMGA2,
BTG2,
HSF1,
INSM1,
SP3,
HHEX,
RELA,
MXD1,
PPARA,
SREBF2,
FOXO1,
NFATC2,
HES1,
NFATC4,
NFIL3,
IFI16,
NFXL1,
TSHZ1,
ZFPM2,
JDP2,
PROX1,
CREBBP,
BCL11A,
ZBTB20,
TSHZ2,
DACH1,
ZNF148,
NFE2L3
|
GO:0001085
|
MF
|
RNA polymerase II transcription factor binding
|
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
WWP2,
KLF4,
KDM1A,
NFATC1,
TP53,
AR,
HCLS1,
TAL1,
XBP1,
ATF4,
ELK1,
CTNNB1,
GATA4,
ID4,
GSK3B,
MEF2A,
SMAD4,
HDAC1,
ANKRD1,
MTDH,
ZFPM2,
CREBBP,
GATA6,
SPEN,
TEAD3,
DACT1,
TRPS1
|
GO:0001087
|
MF
|
transcription factor activity, TFIIB-class binding
|
Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
|
TCF4
|
GO:0001093
|
MF
|
TFIIB-class transcription factor binding
|
Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
|
TCF4
|
GO:0001094
|
MF
|
TFIID-class transcription factor binding
|
Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
|
ERCC1,
ERCC4
|
GO:0001099
|
MF
|
basal RNA polymerase II transcription machinery binding
|
Interacting selectively and non-covalently with the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.
|
LLPH
|
GO:0001102
|
MF
|
RNA polymerase II activating transcription factor binding
|
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
BHLHE40,
NCOR1,
JUN,
RB1,
EGR2,
CREB1,
LMO2,
CTNNB1,
IFI27,
SMAD3,
EXOSC9,
EP300,
CREBBP,
PITX2,
DUSP26,
HIPK2,
BEX1
|
GO:0001103
|
MF
|
RNA polymerase II repressing transcription factor binding
|
Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
|
STAT3,
GTF2A2,
PPARA,
MTA1,
HDAC1,
CHD4,
BBS7,
BBS1,
BBS10,
TTC8,
HDAC2,
GATA6,
BBS2,
MKKS,
TCF7L2
|
GO:0001104
|
MF
|
RNA polymerase II transcription cofactor activity
|
Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery.
|
MED19,
MED7,
MED14,
MED21,
TDG,
PPARGC1B,
MED12,
MED30,
MED15,
MED20,
MED4,
MED17,
MED9,
PPARGC1A,
THRAP3
|
GO:0001105
|
MF
|
RNA polymerase II transcription coactivator activity
|
Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery.
|
SOX12,
SMARCA2,
SMARCA4,
MEF2A,
POU3F1,
SOX4,
HYAL2,
TRIM28,
ANKRD1,
NCOA1,
JADE1,
ZFPM2,
CREBBP,
MED12,
WBP2,
CITED4,
PITX2,
CITED1,
CITED2,
HIPK2,
RERE,
MKL2
|
GO:0001106
|
MF
|
RNA polymerase II transcription corepressor activity
|
Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
|
SIN3B,
URI1,
HDGF,
TLE1,
HDAC1,
N4BP2L2,
PHF12,
CITED2,
HEYL,
RERE,
UXT,
ZNF451
|
GO:0001128
|
MF
|
RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly
|
Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery.
|
MED6
|
GO:0001133
|
MF
|
RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
|
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA by RNA polymerase II and recruiting another transcription factor to the DNA in order to modulate transcription by RNAP II.
|
NR1H2
|
GO:0001135
|
MF
|
transcription factor activity, RNA polymerase II transcription factor recruiting
|
The function of binding to an RNA polymerase II (RNAP II) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP II.
|
MYBL1,
MYBL2,
LIF,
CDC5L
|
GO:0001147
|
MF
|
transcription termination site sequence-specific DNA binding
|
Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon.
|
SETX
|
GO:0001158
|
MF
|
enhancer sequence-specific DNA binding
|
Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
|
XBP1,
YY1,
HMGB2,
GATA4,
SOX9,
LMO4,
ZNF395
|