GO:0030502

BP

negative regulation of bone mineralization

Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.

GREM1, AHSG, SRGN, CCL3, SOX9, HIF1A, TRPM4

GO:0030505

BP

inorganic diphosphate transport

The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

ENPP1, ANKH

GO:0030509

BP

BMP signaling pathway

A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

SLC33A1, SMAD7, SMAD9, SMAD6, GDF9, BMP10, BMP15, BMP2, BMP4, BMP3, SKI, BMP1, EGR1, BMP6, ACVR2A, MAPK3, BMP8B, BMPR1A, ID1, DLX5, UBE2D3, TGFBR3, ACVR1, FSTL1, SMAD4, ACVR2B, BMPR2, RUNX2, SMAD1, HFE, RGMB, ZFYVE16, BMP8A, RYR2, SMAD5, GREM2, SMURF2, USP15

GO:0030510

BP

regulation of BMP signaling pathway

Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.

ITGA3, ACVR2A, PCSK6, XIAP

GO:0030511

BP

positive regulation of transforming growth factor beta receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.

SDCBP, TGFB1I1, LRG1, THBS1, CDKN2B, CDKN1C, ADAM17, DAB2, TGFBR3, SMAD4, STK11, RNF111, FLCN, CITED1, CITED2, HIPK2

GO:0030512

BP

negative regulation of transforming growth factor beta receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.

SMAD7, TGFB1I1, SMAD6, TGFB1, UBC, HSPA5, SKI, SKIL, PBLD, TGFBR1, TGFBR2, NKX2-1, CAV2, RPS27A, UBA52, ADAM17, HTRA3, SMAD3, CAV1, TGFBR3, BAMBI, SMAD2, PEG10, EID2, HTRA1, GLG1, PMEPA1, RASL11B, SMURF2, CHST11, MTMR4, STUB1, SNX6, LEMD3, ZNF451

GO:0030513

BP

positive regulation of BMP signaling pathway

Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.

CYR61, BMP4, GDF5, GATA4, NOTCH1, ILK, SMAD4, BMPR2, HES1, SMAD2, ZNF423, RNF165, KCP, SULF1, GATA6, FBXL15

GO:0030514

BP

negative regulation of BMP signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.

SMAD7, SMAD6, GREM1, DKK1, SKI, SKIL, WNT5A, NBL1, NOTCH1, HTRA3, SOSTDC1, RBPMS2, TMPRSS6, SPG20, SFRP1, BMPER, HTRA1, SOST, HIPK2, TRIM33, LEMD3

GO:0030516

BP

regulation of axon extension

Any process that modulates the rate, direction or extent of axon extension.

APOE, CTTN, DPYSL2, TTL, WDR36, NRCAM, OLFM1, RAB21

GO:0030517

BP

negative regulation of axon extension

Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.

IFRD1, MT3, CDK5, RTN4, RNF6

GO:0030518

BP

intracellular steroid hormone receptor signaling pathway

A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands.

PLPP1, MED14, ESR1, MED12, MED30, GPER1, MED4, MED17, THRAP3, MED16

GO:0030520

BP

intracellular estrogen receptor signaling pathway

Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).

ARID1A, RBFOX2, TADA3, ESR1, CARM1, PPARGC1B, DDX54, ESR2

GO:0030521

BP

androgen receptor signaling pathway

Any series of molecular signals generated as a consequence of an androgen binding to its receptor.

PLPP1, ARID1A, TGFB1I1, MED14, RB1, AR, DNAJA1, CTNNB1, BRCA1, NRIP1, CDK7, FKBP4, NCOA4, NCOA1, MED12, PMEPA1, MED30, MED4, MED17, PPARGC1A, RNF14, THRAP3, MED16, NCOA3

GO:0030522

BP

intracellular receptor signaling pathway

Any series of molecular signals initiated by a ligand binding to an receptor located within a cell.

NR5A2, AR, NR2F1, THRA, ESRRA, NR1D1, NR4A1, NR2F2, ARNT, RORA, AHR, STAT3, NR4A2, NR0B1, PPARD, NOTCH2, PPARA, NR1H3, NR1D2, NCOA2, NCOA1, GLMP, NR4A3, DCBLD2, NR1H4, NCOA3

GO:0030534

BP

adult behavior

Behavior in a fully developed and mature organism.

PCDH17, MAFG, SLC1A2, PTEN, NLGN4X, NR4A3, BBS2, NRXN1

GO:0030539

BP

male genitalia development

The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.

SRD5A1, WT1, BMP6, LHCGR, SRD5A2, CTNNB1, DHCR24, LGR4, TEX15

GO:0030540

BP

female genitalia development

The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure.

SRD5A1, SRD5A2, CHD7

GO:0030573

BP

bile acid catabolic process

The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.

SULT2A1

GO:0030574

BP

collagen catabolic process

The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.

COL1A1, COL3A1, MMP1, COL5A2, CTSD, CTSL, CTSB, COL1A2, MMP2, COL4A2, MMP10, FURIN, COL11A1, COL6A1, COL6A2, COL6A3, COL11A2, MMP9, COL5A1, MMP8, MMP11, COL8A2, CTSS, COL5A3, COL15A1, COL18A1, CTSK, MMP14, MMP15, MMP16, COL4A3, COL10A1, COL4A6, COL13A1, PHYKPL, MMP19, COL12A1, MMP26

GO:0030576

BP

Cajal body organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors.

ZPR1

GO:0030578

BP

PML body organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).

ETS1, HIPK2

GO:0030579

BP

ubiquitin-dependent SMAD protein catabolic process

The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.

TGFB1I1, RNF111, SMURF2, STUB1

GO:0030593

BP

neutrophil chemotaxis

The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.

PIK3CD, PIP5K1C, IL1B, PPBP, ITGB2, S100A8, S100A9, SAA1, CXCL8, CCL3, CCL4, CCL2, CCL5, VAV1, LGALS3, EDN2, C5AR1, CXCR2, SYK, PIK3CG, TGFB2, CXADR, CCL20, CCL8, PDE4D, ITGA9, GBF1, CSF3R, TREM1, CKLF, VAV3

GO:0030595

BP

leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.

PF4, S1PR1, IL10, CORO1A, GPR183, LYST, SBDS

GO:0030641

BP

regulation of cellular pH

Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment.

MAFG

GO:0030643

BP

cellular phosphate ion homeostasis

Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell.

ENPP1

GO:0030644

BP

cellular chloride ion homeostasis

Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell.

CKB

GO:0030656

BP

regulation of vitamin metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

CD320

GO:0030705

BP

cytoskeleton-dependent intracellular transport

The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.

KIF1C, KIF5C, KIF1B, TUBB, TUBA1B, KIF14, TUBA1A, MYO10, KIF13B, STARD9

GO:0030728

BP

ovulation

The release of a mature ovum/oocyte from an ovary.

EREG, HPGD, IL4R, PTGS2, TNFAIP6, KMT2B

GO:0030730

BP

sequestering of triglyceride

The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.

TNF, IL1B, ENPP1

GO:0030801

BP

positive regulation of cyclic nucleotide metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides.

CALM2

GO:0030814

BP

regulation of cAMP metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).

DRD2, PDE4D, PKD2, NPHP3, TBL1XR1

GO:0030816

BP

positive regulation of cAMP metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).

PF4

GO:0030818

BP

negative regulation of cAMP biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).

GRM8, EDN1, EDNRA, OPRL1, NPY2R, AKAP6

GO:0030819

BP

positive regulation of cAMP biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).

RAMP1, ABCA1, PTH, GCG, GHRH, ADRB1, SCT, PTHLH, NME2, MC4R, ADM, ADCYAP1R1, ADCY7, MC2R, MRAP, MRAP2, GPER1

GO:0030821

BP

negative regulation of cAMP catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).

MAPK7

GO:0030822

BP

positive regulation of cAMP catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).

RACK1

GO:0030823

BP

regulation of cGMP metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP.

PDE5A, THBS1, VEGFA

GO:0030825

BP

positive regulation of cGMP metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP.

WNT5A

GO:0030828

BP

positive regulation of cGMP biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP.

APOE, MTNR1A

GO:0030832

BP

regulation of actin filament length

Any process that controls the length of actin filaments in a cell.

EPS8

GO:0030833

BP

regulation of actin filament polymerization

Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.

HAX1, PAK3, FCHSD2, LATS1, HCLS1, RASA1, ARHGAP18

GO:0030834

BP

regulation of actin filament depolymerization

Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament.

WDR1, SH3BGRL3

GO:0030835

BP

negative regulation of actin filament depolymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.

PLEKHH2, LIMA1

GO:0030836

BP

positive regulation of actin filament depolymerization

Any process that activates or increases the frequency, rate or extent of actin depolymerization.

WDR1, F2RL1, DSTN, SEMA5A

GO:0030837

BP

negative regulation of actin filament polymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.

SLIT2, PFN1, PRKCD, TWF1, KANK1, TWF2, MYADM, MKKS

GO:0030838

BP

positive regulation of actin filament polymerization

Any process that activates or increases the frequency, rate or extent of actin polymerization.

MYO1C, ICAM1, PFN1, ALOX15, LMOD1, GRB2, RAC1, DLG1, CTTN, LRRC16A, RICTOR, MLST8, BAIAP2L1, EVL, CDC42EP3, PYCARD

GO:0030844

BP

positive regulation of intermediate filament depolymerization

Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization.

NES

GO:0030850

BP

prostate gland development

The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.

ANXA1, AR, SOX9, FKBP4, SMARCC1

GO:0030851

BP

granulocyte differentiation

The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.

KDM1A, SP3, NKAP, L3MBTL3

GO:0030853

BP

negative regulation of granulocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.

CUL4A, ADIPOQ

GO:0030854

BP

positive regulation of granulocyte differentiation

Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.

HAX1, OGT, HCLS1, RUNX1, KMT2E

GO:0030855

BP

epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

NR5A2, TPP1, TBX1, CBFA2T2, TCF21, PGK1, CDK1, CTSB, GSTA1, ANXA4, ALDOC, PCNA, KRT3, VEGFA, CBR1, LGALS3, WT1, FGFR2, HNRNPH3, PPARG, TAGLN2, ACADVL, CPT1A, AKR1C2, CASP6, DLX5, ELF3, TAGLN, ID3, AKR1C1, CNN3, PTER, DHRS9, BDH2, CDHR2, TOLLIP, EHF, DMBT1, GSTK1

GO:0030856

BP

regulation of epithelial cell differentiation

Any process that modulates the frequency, rate or extent of epithelial cell differentiation.

PRLR, CD24, ASCL1, STAT5B

GO:0030857

BP

negative regulation of epithelial cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.

ZEB1, YAP1, SOX9, CAV1, OSR1

GO:0030858

BP

positive regulation of epithelial cell differentiation

Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.

SOX9

GO:0030859

BP

polarized epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis.

DLG5

GO:0030862

BP

positive regulation of polarized epithelial cell differentiation

Any process that activates or increases the rate or extent of polarized epithelial cell differentiation.

NUMB, AHI1

GO:0030865

BP

cortical cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.

EPB41L3

GO:0030866

BP

cortical actin cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.

ROCK2, TNF, RHOQ, CALR, CDK5, DLG1, STRIP1, PRKCDBP, FMNL2, EPB41L1, EPB41L3, TLN1

GO:0030878

BP

thyroid gland development

The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.

HOXA3, TBX1, RAF1, THRA, MAPK3, MAPK1, NKX2-1, SMAD3, MAP2K1, HHEX, PAX8, DUOX2

GO:0030879

BP

mammary gland development

The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.

BCL2L11, GLI2, TDGF1, B4GALT1, ITGA2, SOX9, FASN, NRG1, CAV1, ARHGAP5, PYGO2, IRS2

GO:0030886

BP

negative regulation of myeloid dendritic cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.

IL10

GO:0030888

BP

regulation of B cell proliferation

Any process that modulates the frequency, rate or extent of B cell proliferation.

AHR

GO:0030889

BP

negative regulation of B cell proliferation

Any process that stops, prevents or reduces the rate or extent of B cell proliferation.

TNFRSF21, LYN, IL10, MNDA, PKN1, INPP5D, PAWR

GO:0030890

BP

positive regulation of B cell proliferation

Any process that activates or increases the rate or extent of B cell proliferation.

TLR4, SASH3, ADA, TFRC, CD74, PTPRC, BCL2, MIF, GPR183, CDKN1A, BCL6, TIRAP, CD81, MEF2C, NFATC2, PELI1, CLCF1, VAV3, SLC39A10, TNFSF13B, IRS2

GO:0030900

BP

forebrain development

The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).

ARID1A, DCLK1, DKK1, APP, FYN, CNP, NR2F2, SSTR1, OTX2, NKX2-1, ATRX, NOTCH1, NDST1, LRP2, E2F1, POU3F1, STIL, FRS2, DLC1, PCDH9, PPARGC1A, MAPK8IP3

GO:0030901

BP

midbrain development

The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).

UQCRQ, SMAD9, FGFR1, FGFR2, CXCR2, OTX2, NDST1, HES1, SMAD1, WLS, KDM7A, DLG5, UCHL5

GO:0030902

BP

hindbrain development

The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).

NFIB, SMAD9, ALDH1A2, GLI2, CTNNB1, SMAD1, WLS, AHI1

GO:0030903

BP

notochord development

The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.

COBL, YAP1, SOX9, ID3, STIL, TEAD2

GO:0030910

BP

olfactory placode formation

The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.

AXIN1, PROX1

GO:0030913

BP

paranodal junction assembly

Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier.

GNPAT, CD9, ANK2, EPB41L3

GO:0030916

BP

otic vesicle formation

The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear.

FGFR2, SOX9

GO:0030917

BP

midbrain-hindbrain boundary development

The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.

LRP6

GO:0030947

BP

regulation of vascular endothelial growth factor receptor signaling pathway

Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.

VEGFC, FZD4

GO:0030948

BP

negative regulation of vascular endothelial growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.

PDCD6, HHEX

GO:0030949

BP

positive regulation of vascular endothelial growth factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.

FGF18, IL1B, VTN, ITGB3, PRKCB, ITGA5, VEGFA, MT3, ARNT, FGF9, GRB10, HIF1A, PRKD2

GO:0030950

BP

establishment or maintenance of actin cytoskeleton polarity

Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures.

RICTOR, MAPKAP1

GO:0030951

BP

establishment or maintenance of microtubule cytoskeleton polarity

Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.

LMNA, CKAP5, KIF2C

GO:0030953

BP

astral microtubule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.

EZR, RAB11A, DLG1, KPNB1, CEP120

GO:0030968

BP

endoplasmic reticulum unfolded protein response

The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.

PPP1R15A, STC2, VAPB, HSPA5, XBP1, ATF6, CTH, VCP, SYVN1, EDEM1, CREB3L1, ERO1A, VIMP, EDEM3, DERL2, RNF121, UGGT1, AMFR, STUB1, TBL2

GO:0030970

BP

retrograde protein transport, ER to cytosol

The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.

TMEM129, HSP90B1, VCP, SYVN1, UFD1L, FAF2, VIMP, DERL2, SEL1L

GO:0030997

BP

regulation of centriole-centriole cohesion

Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker.

CTNNB1

GO:0031000

BP

response to caffeine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.

IL6, CAD, PPARG, DHODH, HDAC1, RYR2, HDAC2, DNMT3B

GO:0031001

BP

response to brefeldin A

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus.

HID1

GO:0031016

BP

pancreas development

The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.

ALDH1A2, GDF11, CTNNB1, HHEX, ACVR2B, HES1, SMAD2, ILDR2, PROX1, TCF7L2

GO:0031017

BP

exocrine pancreas development

The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.

INSR, XBP1, WLS, PPDPF

GO:0031018

BP

endocrine pancreas development

The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.

PAX4, ANXA1, IL6, IL6R, AKT1, SOX9, INSM1, SOX4, FOXO1

GO:0031022

BP

nuclear migration along microfilament

The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.

SYNE2, SUN2

GO:0031032

BP

actomyosin structure organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.

FRMD3, MYH9, CNN1, ACTC1, CNN3, CDC42BPA, FRMD6, TRPM7, EPB41L4B, EPB41L1, EPB41L4A, LIMCH1, EPB41L3, CDC42BPB, F11R

GO:0031034

BP

myosin filament assembly

The aggregation, arrangement and bonding together of a filament composed of myosin molecules.

RAP1GDS1

GO:0031047

BP

gene silencing by RNA

Any process in which RNA molecules inactivate expression of target genes.

NUPL2, POLR2D, CNOT3, PRKRA, NUP155, TPR, POLR2E, POLR2A, POLR2B, POLR2I, NUP62, NUP153, RANBP2, POLR2J, POLR2K, NUP107, POLR2G, HIST1H4A, POLR2L, HIST1H3D, RAE1, H3F3A, FMR1, NCBP1, NUP160, TSN, PIWIL4, NUP93, TDRD9, TNRC6A, NUP43, NUP37, NUP35, NUP210, NUP205, SEH1L, NUP88, NDC1, NUP58, NUP85, CNOT7, AGO2, NUP50, TNRC6B, DICER1

GO:0031052

BP

chromosome breakage

Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage.

BRCA1, BRCA2, HMGA2

GO:0031053

BP

primary miRNA processing

Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.

HNRNPA2B1, SMAD3, SMAD2, SMAD1, MRPL44

GO:0031054

BP

pre-miRNA processing

Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.

PRKRA, MRPL44, LIN28A, AGO4, AGO2, DICER1

GO:0031060

BP

regulation of histone methylation

Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones.

MTHFR

GO:0031062

BP

positive regulation of histone methylation

Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones.

PAXBP1

GO:0031063

BP

regulation of histone deacetylation

Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones.

ZNHIT1, TADA3, MAPK8

GO:0031064

BP

negative regulation of histone deacetylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones.

SKI, FOXP3