GO:0002590

BP

negative regulation of antigen processing and presentation of peptide antigen via MHC class I

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.

TAPBPL

GO:0002605

BP

negative regulation of dendritic cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.

THBS1

GO:0002606

BP

positive regulation of dendritic cell antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.

CD74, SLC11A1

GO:0002626

BP

negative regulation of T cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation.

HFE

GO:0002634

BP

regulation of germinal center formation

Any process that modulates the frequency, rate, or extent of germinal center formation.

TNFAIP3, BCL6, MEF2C, PKN1

GO:0002636

BP

positive regulation of germinal center formation

Any process that activates or increases the frequency, rate, or extent of germinal center formation.

ADA, TNFSF13B

GO:0002637

BP

regulation of immunoglobulin production

Any process that modulates the frequency, rate, or extent of immunoglobulin production.

PKN1

GO:0002638

BP

negative regulation of immunoglobulin production

Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production.

PRKDC

GO:0002639

BP

positive regulation of immunoglobulin production

Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.

SASH3, XBP1, IL4R, CLCF1

GO:0002643

BP

regulation of tolerance induction

Any process that modulates the frequency, rate, or extent of tolerance induction.

HMGB1, MARCH7

GO:0002645

BP

positive regulation of tolerance induction

Any process that activates or increases the frequency, rate, or extent of tolerance induction.

HLA-G

GO:0002651

BP

positive regulation of tolerance induction to self antigen

Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen.

TGFBR2

GO:0002663

BP

positive regulation of B cell tolerance induction

Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction.

TGFBR2

GO:0002666

BP

positive regulation of T cell tolerance induction

Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.

HLA-G, TGFBR2

GO:0002667

BP

regulation of T cell anergy

Any process that modulates the frequency, rate, or extent of T cell anergy.

FOXP3

GO:0002669

BP

positive regulation of T cell anergy

Any process that activates or increases the frequency, rate, or extent of T cell anergy.

FOXP3

GO:0002674

BP

negative regulation of acute inflammatory response

Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.

INS, APCS, GSTP1, ADORA1, PPARG, ASH1L

GO:0002675

BP

positive regulation of acute inflammatory response

Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.

IL6, IL6ST, PIK3CG, ADAM8, NPY5R, OSMR

GO:0002676

BP

regulation of chronic inflammatory response

Any process that modulates the frequency, rate, or extent of a chronic inflammatory response.

CCL5

GO:0002677

BP

negative regulation of chronic inflammatory response

Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.

CYP19A1, TNFAIP3, FOXP3

GO:0002679

BP

respiratory burst involved in defense response

A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.

PIK3CD, MPO, PIK3CG

GO:0002682

BP

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

ORM1, ORM2

GO:0002683

BP

negative regulation of immune system process

Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.

SOX9

GO:0002684

BP

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

PRKDC, AQP3

GO:0002685

BP

regulation of leukocyte migration

Any process that modulates the frequency, rate, or extent of leukocyte migration.

ANXA1

GO:0002686

BP

negative regulation of leukocyte migration

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.

IL33, ADA, HMOX1, ADORA1, RABGEF1

GO:0002687

BP

positive regulation of leukocyte migration

Any process that activates or increases the frequency, rate, or extent of leukocyte migration.

VEGFA, ITGA2, KITLG, ZP3, CCL8

GO:0002689

BP

negative regulation of leukocyte chemotaxis

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.

SLIT2

GO:0002690

BP

positive regulation of leukocyte chemotaxis

Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.

PPBP, PF4, IL6, IL6R, EDN2, CXCL5, F2RL1, ADAM17, CXCL6, ZNF580, GPSM3

GO:0002692

BP

negative regulation of cellular extravasation

Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation.

BCR, ABR

GO:0002693

BP

positive regulation of cellular extravasation

Any process that activates or increases the frequency, rate, or extent of cellular extravasation.

ICAM1, CCL2

GO:0002695

BP

negative regulation of leukocyte activation

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.

GPER1

GO:0002710

BP

negative regulation of T cell mediated immunity

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.

DUSP22

GO:0002711

BP

positive regulation of T cell mediated immunity

Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity.

IL1B

GO:0002715

BP

regulation of natural killer cell mediated immunity

Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.

HLA-E

GO:0002717

BP

positive regulation of natural killer cell mediated immunity

Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.

HLA-E

GO:0002724

BP

regulation of T cell cytokine production

Any process that modulates the frequency, rate, or extent of T cell cytokine production.

TRPM4

GO:0002725

BP

negative regulation of T cell cytokine production

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.

HFE, FOXP3

GO:0002726

BP

positive regulation of T cell cytokine production

Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.

MAP3K7, SASH3, TNFSF4, B2M

GO:0002730

BP

regulation of dendritic cell cytokine production

Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.

TLR4, TLR3

GO:0002731

BP

negative regulation of dendritic cell cytokine production

Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production.

JAK3

GO:0002737

BP

negative regulation of plasmacytoid dendritic cell cytokine production

Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.

BST2

GO:0002740

BP

negative regulation of cytokine secretion involved in immune response

Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response.

TNF, APOA1, APOA2, IL10, ANGPT1, LILRB1

GO:0002741

BP

positive regulation of cytokine secretion involved in immune response

Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response.

WNT5A, F2RL1, TRIM6

GO:0002755

BP

MyD88-dependent toll-like receptor signaling pathway

Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

TLR4, IRAK2, MAP3K7, TLR5, TLR2, CD14, UBC, HSPD1, CD36, IRAK1, TIRAP, RPS27A, UBA52, TLR1, TAB1, TAB3, IRAK3

GO:0002756

BP

MyD88-independent toll-like receptor signaling pathway

Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

TLR4, TLR3, CD14, UBC, RPS27A, UBA52

GO:0002757

BP

immune response-activating signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response.

SKAP2

GO:0002761

BP

regulation of myeloid leukocyte differentiation

Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.

NDFIP1

GO:0002762

BP

negative regulation of myeloid leukocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.

LYN, NME1, NME2

GO:0002763

BP

positive regulation of myeloid leukocyte differentiation

Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.

KITLG

GO:0002764

BP

immune response-regulating signaling pathway

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response.

CTSH

GO:0002767

BP

immune response-inhibiting cell surface receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response.

HLA-G, LILRB1

GO:0002768

BP

immune response-regulating cell surface receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.

LYN, FGR, CD24

GO:0002774

BP

Fc receptor mediated inhibitory signaling pathway

A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.

LYN, LILRB1

GO:0002778

BP

antibacterial peptide production

The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels.

KLK3

GO:0002790

BP

peptide secretion

The controlled release of a peptide from a cell or a tissue.

ABCA1, TRPV1

GO:0002792

BP

negative regulation of peptide secretion

Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.

CD74

GO:0002793

BP

positive regulation of peptide secretion

Any process that activates or increases the frequency, rate, or extent of peptide secretion.

S100A8, S100A9, ADORA1, NPY2R

GO:0002819

BP

regulation of adaptive immune response

Any process that modulates the frequency, rate, or extent of an adaptive immune response.

CD48, IRF1, TNFSF4, DUSP10

GO:0002820

BP

negative regulation of adaptive immune response

Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.

ALOX15, SAMSN1

GO:0002821

BP

positive regulation of adaptive immune response

Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.

IL6ST, FADD, EIF2AK4, PYCARD

GO:0002826

BP

negative regulation of T-helper 1 type immune response

Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.

IL33, IL1RL1

GO:0002827

BP

positive regulation of T-helper 1 type immune response

Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.

IL12RB1, SLC11A1

GO:0002829

BP

negative regulation of type 2 immune response

Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.

NDFIP1

GO:0002830

BP

positive regulation of type 2 immune response

Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.

IL33, CD74, TNFSF4

GO:0002840

BP

regulation of T cell mediated immune response to tumor cell

Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell.

HMGB1

GO:0002842

BP

positive regulation of T cell mediated immune response to tumor cell

Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell.

HSPD1

GO:0002851

BP

positive regulation of peripheral T cell tolerance induction

Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction.

FOXP3

GO:0002860

BP

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.

PVR, IL12A

GO:0002862

BP

negative regulation of inflammatory response to antigenic stimulus

Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.

GPX1, PSMB4

GO:0002863

BP

positive regulation of inflammatory response to antigenic stimulus

Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.

CD28

GO:0002865

BP

negative regulation of acute inflammatory response to antigenic stimulus

Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.

NPY5R, VIMP

GO:0002866

BP

positive regulation of acute inflammatory response to antigenic stimulus

Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.

CNR1

GO:0002875

BP

negative regulation of chronic inflammatory response to antigenic stimulus

Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.

IL10

GO:0002876

BP

positive regulation of chronic inflammatory response to antigenic stimulus

Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.

TNF

GO:0002882

BP

positive regulation of chronic inflammatory response to non-antigenic stimulus

Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.

ADORA2B

GO:0002891

BP

positive regulation of immunoglobulin mediated immune response

Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.

TNFSF4

GO:0002902

BP

regulation of B cell apoptotic process

Any process that modulates the frequency, rate, or extent of B cell apoptotic process.

LYN, PTEN

GO:0002903

BP

negative regulation of B cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.

BCL6, AURKB, FOXP1, SLC39A10, NOC2L, IRS2

GO:0002904

BP

positive regulation of B cell apoptotic process

Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process.

IL10, BAX, FNIP1

GO:0002906

BP

negative regulation of mature B cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process.

BCL10, ADA, CD74, MIF

GO:0002922

BP

positive regulation of humoral immune response

Any process that activates or increases the frequency, rate, or extent of a humoral immune response.

ZP3

GO:0002925

BP

positive regulation of humoral immune response mediated by circulating immunoglobulin

Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.

TNF

GO:0002930

BP

trabecular meshwork development

The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor.

CYP1B1

GO:0002931

BP

response to ischemia

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.

NOL3, AIFM1, UCHL1, BCL2, HSPD1, EEF2, EGR1, PPIF, MAP2K6, CAV1, EIF4EBP1, KCNJ11, FAM175B, CPEB4, BVES, NDNF, PANX2, PANX1, MAP3K5, CIB1, PPARGC1A, HYOU1

GO:0002933

BP

lipid hydroxylation

The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid.

CYP1A1, CYP3A4, CYP3A5, CYP3A7

GO:0002934

BP

desmosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.

DSP, DSG2, NECTIN1, PERP

GO:0002943

BP

tRNA dihydrouridine synthesis

The process whereby a uridine in a transfer RNA is converted to dihydrouridine.

DUS4L

GO:0003006

BP

developmental process involved in reproduction

A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.

ALPL, CYSTM1

GO:0003007

BP

heart morphogenesis

The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

KDM6A, FLRT2, TBX1, ALDH1A2, INSR, TH, GAA, VEGFA, COL5A1, HTR2B, EPHB4, TGFB2, TGFBR3, PTK2, PTCH1, TAB1, NIPBL, DLC1, CHD7, BAZ1B, ZMIZ1

GO:0003009

BP

skeletal muscle contraction

A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.

HSP90AA1, CHRNB1, EEF2, TNNT1, TNNI3, HOMER1, JSRP1

GO:0003014

BP

renal system process

A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).

AGT, BCL2, BMP4, FAS, PKN1

GO:0003016

BP

respiratory system process

A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.

KDM6A, ZFAND5, ECEL1, FLT4, TCF15, CCBE1, SEPN1

GO:0003017

BP

lymph circulation

The flow of lymph through the body of an animal.

HEG1

GO:0003025

BP

regulation of systemic arterial blood pressure by baroreceptor feedback

The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control.

NAV2

GO:0003026

BP

regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback

The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control.

ASIC2

GO:0003044

BP

regulation of systemic arterial blood pressure mediated by a chemical signal

The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine.

SLC2A5

GO:0003050

BP

regulation of systemic arterial blood pressure by atrial natriuretic peptide

The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide.

RASL10B

GO:0003051

BP

angiotensin-mediated drinking behavior

The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst.

AGT

GO:0003056

BP

regulation of vascular smooth muscle contraction

Any process that increases the frequency, rate or extent of vascular smooth muscle contraction.

CHRM3