GO:0003057

BP

regulation of the force of heart contraction by chemical signal

The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.

NOS3, CAV1

GO:0003058

BP

hormonal regulation of the force of heart contraction

The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.

EDN2

GO:0003062

BP

regulation of heart rate by chemical signal

The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine.

SREBF1

GO:0003064

BP

regulation of heart rate by hormone

The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.

YWHAE, KCNH2

GO:0003065

BP

positive regulation of heart rate by epinephrine

The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction.

TPM1

GO:0003069

BP

vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure

The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure.

SOD2

GO:0003073

BP

regulation of systemic arterial blood pressure

The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

DDAH1, AR, NCALD, POSTN

GO:0003081

BP

regulation of systemic arterial blood pressure by renin-angiotensin

The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.

ACE, AGTR1

GO:0003084

BP

positive regulation of systemic arterial blood pressure

The process that increases the force with which blood travels through the systemic arterial circulatory system.

ACE, NR2F2, AVPR2, ADRA1A, SPX, WNK1

GO:0003085

BP

negative regulation of systemic arterial blood pressure

The process that reduces the force with which blood travels through the systemic arterial circulatory system.

ARHGAP42, BMPR2, KCNK6

GO:0003091

BP

renal water homeostasis

Renal process involved in the maintenance of an internal steady state of water in the body.

ADCY3, ADCY9, PRKAR1A, PRKAR2A, PRKACA, CYP11B2, AVPR2, PRKAR2B, AQP2, ADCY7, RAB11A, RAB11FIP2, AQP3, MYO5B

GO:0003093

BP

regulation of glomerular filtration

Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule.

ADORA1, EMP2, PTPRO

GO:0003094

BP

glomerular filtration

The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.

MCAM, MYO1E, SULF2, SULF1, XPNPEP3

GO:0003097

BP

renal water transport

The directed movement of water (H2O) by the kidney.

AQP2

GO:0003099

BP

positive regulation of the force of heart contraction by chemical signal

Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.

EDN2

GO:0003100

BP

regulation of systemic arterial blood pressure by endothelin

The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor.

EDN1, EDN2, NOS3, ECE1

GO:0003104

BP

positive regulation of glomerular filtration

Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.

PDGFB, GJA1, F2RL1, GAS6

GO:0003105

BP

negative regulation of glomerular filtration

Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.

F2R, GJA5, PTPRO

GO:0003127

BP

detection of nodal flow

The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry.

PKD2

GO:0003130

BP

BMP signaling pathway involved in heart induction

A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction.

BMP2, BMP4

GO:0003131

BP

mesodermal-endodermal cell signaling

Any process that mediates the transfer of information from mesodermal cells to endodermal cells.

HMGA2

GO:0003138

BP

primary heart field specification

The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.

MEF2C

GO:0003139

BP

secondary heart field specification

The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).

BMP4, MEF2C, SMARCD3

GO:0003142

BP

cardiogenic plate morphogenesis

The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field.

SOX17

GO:0003143

BP

embryonic heart tube morphogenesis

The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.

YAP1, ACVR1, HES1, TEAD2, RYR2, SOX17

GO:0003147

BP

neural crest cell migration involved in heart formation

The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.

FOLR1

GO:0003148

BP

outflow tract septum morphogenesis

The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.

TBX1, SMAD6, BMP4, FGFR2, BMPR1A, TGFBR2, TGFB2, SMAD4, BMPR2, ZFPM2, GATA6, PARVA

GO:0003149

BP

membranous septum morphogenesis

The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.

WHSC1, BMP4, FGFR2, TGFBR2, TGFB2, ID2

GO:0003150

BP

muscular septum morphogenesis

The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.

TGFBR3

GO:0003151

BP

outflow tract morphogenesis

The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.

TBX1, DHRS3, JUN, VEGFA, NPY1R, GJA5, BMPR1A, TGFBR2, NPY2R, TGFBR3, MEF2C, ILK, BMPR2, HES1, NPY5R, HIF1A, NIPBL, CITED2, SEMA3C, SOX17, HEYL, PLXND1

GO:0003156

BP

regulation of animal organ formation

Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.

WT1, CITED2

GO:0003157

BP

endocardium development

The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.

NOTCH1, STK4

GO:0003158

BP

endothelium development

The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.

GJA1, GJA5, SLC40A1

GO:0003160

BP

endocardium morphogenesis

The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.

NOTCH1

GO:0003161

BP

cardiac conduction system development

The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.

GJA5, BMPR1A, CDC42, NRG1

GO:0003162

BP

atrioventricular node development

The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.

NOTCH1

GO:0003165

BP

Purkinje myocyte development

The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.

DSG2

GO:0003166

BP

bundle of His development

The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.

ID2

GO:0003169

BP

coronary vein morphogenesis

The process in which the anatomical structures of veins of the heart are generated and organized.

VEGFA, NOTCH1

GO:0003170

BP

heart valve development

The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion.

SHOX2, SOX9

GO:0003171

BP

atrioventricular valve development

The progression of the atrioventricular valve over time, from its formation to the mature structure.

PITX2

GO:0003174

BP

mitral valve development

The progression of the mitral valve over time, from its formation to the mature structure.

GJA5

GO:0003179

BP

heart valve morphogenesis

The process in which the structure of a heart valve is generated and organized.

TGFB1, SOX9, TGFB2

GO:0003180

BP

aortic valve morphogenesis

The process in which the structure of the aortic valve is generated and organized.

BMP4, EFNA1, NOTCH1, TWIST1

GO:0003181

BP

atrioventricular valve morphogenesis

The process in which the structure of the atrioventricular valve is generated and organized.

CYR61, BMP2, TGFBR2, NOTCH1, TGFB2, MDM2, ACVR1, HEYL

GO:0003183

BP

mitral valve morphogenesis

The process in which the structure of the mitral valve is generated and organized.

SMAD6, EFNA1, BMPR1A, ACVR1, SOX4, BMPR2, TWIST1

GO:0003184

BP

pulmonary valve morphogenesis

The process in which the structure of the pulmonary valve is generated and organized.

SMAD6, BMP4, NOTCH1, TGFB2, JAG1, NOTCH2, HEYL, HEY1

GO:0003185

BP

sinoatrial valve morphogenesis

The process in which the structure of the sinoatrial valve is generated and organized.

MEF2C

GO:0003186

BP

tricuspid valve morphogenesis

The process in which the structure of the tricuspid valve is generated and organized.

BMPR1A, TGFBR2, BMPR2

GO:0003188

BP

heart valve formation

The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

SOX9

GO:0003190

BP

atrioventricular valve formation

The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

SMAD4, OLFM1, HEY1

GO:0003192

BP

mitral valve formation

The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

NOTCH1

GO:0003193

BP

pulmonary valve formation

The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

GJA5

GO:0003197

BP

endocardial cushion development

The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

BMP4, ERBB3, GATA4, BMPR2

GO:0003198

BP

epithelial to mesenchymal transition involved in endocardial cushion formation

A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.

SNAI2, NOTCH1, SMAD4, HEYL, HEY1

GO:0003199

BP

endocardial cushion to mesenchymal transition involved in heart valve formation

A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.

EFNA1

GO:0003203

BP

endocardial cushion morphogenesis

The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

BMP2, BMPR1A, NOTCH1, SOX9, TGFB2, MDM2, ACVR1, TWIST1, HEYL, HEY1

GO:0003205

BP

cardiac chamber development

The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.

ARID1A

GO:0003207

BP

cardiac chamber formation

The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.

NOTCH1

GO:0003208

BP

cardiac ventricle morphogenesis

The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

GATA4, NOTCH1, HIF1A, HEYL, DLL4, HEY1

GO:0003209

BP

cardiac atrium morphogenesis

The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.

SHOX2, NOTCH1, SOS1, DLL4, HEG1

GO:0003211

BP

cardiac ventricle formation

The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

MEF2C, SOX4

GO:0003213

BP

cardiac right atrium morphogenesis

The process in which the right cardiac atrium is generated and organized.

NOTCH1

GO:0003214

BP

cardiac left ventricle morphogenesis

The process in which the left cardiac ventricle is generated and organized.

CPE, TGFBR2, NOTCH1, NPY2R, NPY5R

GO:0003215

BP

cardiac right ventricle morphogenesis

The process in which the right cardiac ventricle is generated and organized.

BMPR1A, GATA4, TGFB2, JAG1, SOX4, PPP1R13L, SEMA3C

GO:0003219

BP

cardiac right ventricle formation

The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.

NOTCH1, SMARCD3

GO:0003220

BP

left ventricular cardiac muscle tissue morphogenesis

The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.

SMAD4, RYR2

GO:0003221

BP

right ventricular cardiac muscle tissue morphogenesis

The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.

ZFPM2

GO:0003222

BP

ventricular trabecula myocardium morphogenesis

The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.

UBE4B, BMPR1A, TGFBR1, NOTCH1, TGFB2, NRG1, DLL4, CHD7, HEG1

GO:0003223

BP

ventricular compact myocardium morphogenesis

The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized.

DSP, BMPR1A, TGFBR1, TGFBR3

GO:0003226

BP

right ventricular compact myocardium morphogenesis

The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized.

CHD7

GO:0003229

BP

ventricular cardiac muscle tissue development

The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.

PPP1R13L

GO:0003231

BP

cardiac ventricle development

The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

TMEM65

GO:0003241

BP

growth involved in heart morphogenesis

Developmental growth that contributes to the shaping of the heart.

NOTCH1

GO:0003245

BP

cardiac muscle tissue growth involved in heart morphogenesis

The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart.

S1PR1

GO:0003251

BP

positive regulation of cell proliferation involved in heart valve morphogenesis

Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.

SMAD4

GO:0003252

BP

negative regulation of cell proliferation involved in heart valve morphogenesis

Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.

BMPR2

GO:0003253

BP

cardiac neural crest cell migration involved in outflow tract morphogenesis

The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract.

FOLR1, TWIST1, PITX2

GO:0003254

BP

regulation of membrane depolarization

Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.

FGF12, B2M, CAMK2D, FHL1, NEDD4L, RANGRF

GO:0003256

BP

regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.

NOTCH1

GO:0003257

BP

positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.

GREM1

GO:0003266

BP

regulation of secondary heart field cardioblast proliferation

Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).

CTNNB1, HES1

GO:0003270

BP

Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation

The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.

NOTCH1

GO:0003272

BP

endocardial cushion formation

The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

BMPR1A

GO:0003273

BP

cell migration involved in endocardial cushion formation

The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

SNAI2, NOTCH1

GO:0003274

BP

endocardial cushion fusion

The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping.

TGFBR2, TGFB2, ACVR1

GO:0003278

BP

apoptotic process involved in heart morphogenesis

Any apoptotic process that contributes to the shaping of the heart.

CYR61

GO:0003279

BP

cardiac septum development

The progression of a cardiac septum over time, from its initial formation to the mature structure.

BMP4, NDST1, TAB1, PCSK5, ADAMTS6, PLXND1

GO:0003281

BP

ventricular septum development

The progression of the ventricular septum over time from its formation to the mature structure.

CYR61, SMAD6, GJA5, GATA4, LMO4, AP2B1, LRP2, MDM2, NPRL3, PTK7, HES1, LTBP1, TRIP11, FRS2, DCTN5, HEG1, SUFU

GO:0003283

BP

atrial septum development

The progression of the atrial septum over time, from its initial formation to the mature structure.

GJA5, MDM2, ANK2, NPHP3

GO:0003284

BP

septum primum development

The progression of the septum primum over time, from its formation to the mature structure.

GJA5

GO:0003289

BP

atrial septum primum morphogenesis

The process in which anatomical structure of an atrial septum primum is generated and organized.

WHSC1, GATA4, TGFB2, ACVR1, SOX4

GO:0003290

BP

atrial septum secundum morphogenesis

The process in which anatomical structure of an atrial septum secundum is generated and organized.

WHSC1, GATA4

GO:0003294

BP

atrial ventricular junction remodeling

The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle.

GJA1, GJA5

GO:0003300

BP

cardiac muscle hypertrophy

The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.

LEP, HTR2B, TIAM1, TTN, RYR2, HDAC2

GO:0003308

BP

negative regulation of Wnt signaling pathway involved in heart development

Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.

BMP2, SOX17

GO:0003309

BP

type B pancreatic cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.

INSM1, GATA6

GO:0003310

BP

pancreatic A cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.

INSM1, GATA6

GO:0003323

BP

type B pancreatic cell development

The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.

BMP4, BMP6, WNT5A, CDK6, INSM1

GO:0003331

BP

positive regulation of extracellular matrix constituent secretion

Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.

AGT, CPB2, RGCC