GO:0002230

BP

positive regulation of defense response to virus by host

Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.

TRAF3IP2, IL12RB1, MAVS, LILRB1, TRIM6, APOBEC3G, EIF2AK4, PYCARD

GO:0002236

BP

detection of misfolded protein

The series of events in which a misfolded protein stimulus is received and converted into a molecular signal.

HSPD1

GO:0002237

BP

response to molecule of bacterial origin

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.

BCL10, CXCL8, CXCL2, TNFAIP3, IL10, CD24

GO:0002244

BP

hematopoietic progenitor cell differentiation

The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.

RBM47, EML1, ZBTB24, TGFB1, INHBA, PTPRC, TOP2A, BMP4, EEF2, FST, CEBPD, PSEN1, HYAL2, ARHGEF7, RRS1, ESCO2, PAPD4, TMEM91, SFRP1, C12orf29, BVES, SSBP3, ANLN, WDR7, PRRC2C

GO:0002246

BP

wound healing involved in inflammatory response

The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.

HMOX1

GO:0002248

BP

connective tissue replacement involved in inflammatory response wound healing

The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response.

TGFB1, IL1A, F2R, HIF1A

GO:0002250

BP

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

PIK3CD, RIPK2, JAK2, TNFRSF21, BCL10, IFNA1 , CD4, FGA, FGB, ANXA1, IFNA16, PRKCB, FYN, CTSL, LYN, CTSH, HLA-E, CD46, RAG1, TFEB, CTSS, CD6, GPR183, CSK, SYK, PIK3CG, JAK3, ALCAM, ADGRE1, MARCH8, LAIR1, ERAP2, RNF19B, VTCN1, IFNE, LILRB1, TRPM4, CLEC4D, FCGR1B, OTUB1, DCLRE1C, JAM3, PRKD2, CD244, CD209, PAG1, ERAP1, EIF2AK4, LAMP3, TNFRSF11A

GO:0002260

BP

lymphocyte homeostasis

The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.

SKIL, SLC40A1

GO:0002262

BP

myeloid cell homeostasis

The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.

BCL2L11, BAX, FOXP3

GO:0002263

BP

cell activation involved in immune response

A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.

GBF1

GO:0002268

BP

follicular dendritic cell differentiation

The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell.

BCL3

GO:0002277

BP

myeloid dendritic cell activation involved in immune response

The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

DOCK2, PYCARD

GO:0002281

BP

macrophage activation involved in immune response

A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

TYROBP, SYK

GO:0002282

BP

microglial cell activation involved in immune response

The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

TLR3, IL33

GO:0002283

BP

neutrophil activation involved in immune response

The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

TYROBP, SYK

GO:0002286

BP

T cell activation involved in immune response

The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.

IFNA1 , IFNA16, LCP1, PSEN1, F2RL1, IFNE, EIF2AK4

GO:0002291

BP

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.

ICAM1

GO:0002292

BP

T cell differentiation involved in immune response

The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.

CLEC4D

GO:0002309

BP

T cell proliferation involved in immune response

The expansion of a T cell population by cell division as part of an immune response.

SLC11A1, RPS6, LILRB1

GO:0002312

BP

B cell activation involved in immune response

The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

GPR183

GO:0002313

BP

mature B cell differentiation involved in immune response

The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response.

GPR183

GO:0002314

BP

germinal center B cell differentiation

The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).

ADA, CDH17, ITFG2

GO:0002315

BP

marginal zone B cell differentiation

The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).

BCL3, NOTCH2, CDH17

GO:0002316

BP

follicular B cell differentiation

The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region.

PLCG2

GO:0002317

BP

plasma cell differentiation

The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.

ITM2A, LGALS1

GO:0002318

BP

myeloid progenitor cell differentiation

The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.

KIT, JAM3

GO:0002320

BP

lymphoid progenitor cell differentiation

The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.

BCL2, KIT, BMP4

GO:0002322

BP

B cell proliferation involved in immune response

The expansion of a B cell population by cell division following B cell activation during an immune response.

TLR4, PLCL2

GO:0002323

BP

natural killer cell activation involved in immune response

The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

IFNA1 , IFNA16, IFNE, CD244

GO:0002326

BP

B cell lineage commitment

The process in which a lymphoid progenitor cell becomes committed to become any type of B cell.

BCL2, TCF3, PRKDC

GO:0002327

BP

immature B cell differentiation

The process in which a precursor cell type acquires the specialized features of an immature B cell.

KIT, FNIP1

GO:0002328

BP

pro-B cell differentiation

The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.

PRKDC, SOX4

GO:0002329

BP

pre-B cell differentiation

The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.

LRRC8A

GO:0002331

BP

pre-B cell allelic exclusion

Expression of a single heavy chain allele during pre-B cell differentiation.

RAG1

GO:0002337

BP

B-1a B cell differentiation

The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.

PLCL2

GO:0002347

BP

response to tumor cell

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell.

HNMT

GO:0002352

BP

B cell negative selection

Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.

BAX

GO:0002358

BP

B cell homeostatic proliferation

The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus.

BAX

GO:0002360

BP

T cell lineage commitment

The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell.

PRKDC

GO:0002362

BP

CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment

The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell.

FOXP3

GO:0002366

BP

leukocyte activation involved in immune response

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

SYK, CLEC7A

GO:0002367

BP

cytokine production involved in immune response

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.

MR1

GO:0002368

BP

B cell cytokine production

Any process that contributes to cytokine production by a B cell.

HSPD1

GO:0002369

BP

T cell cytokine production

Any process that contributes to cytokine production by a T cell.

SLC11A1, DLG1

GO:0002371

BP

dendritic cell cytokine production

Any process that contributes to cytokine production by a dendritic cell.

KIT

GO:0002374

BP

cytokine secretion involved in immune response

The regulated release of cytokines from a cell that contributes to an immune response.

TLR2, TREM1

GO:0002376

BP

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

CD5L, FCMR, HP, PTMS, ADSS, LRMP, SQSTM1, ADSSL1, PIBF1, NUDCD1, TAPBPL

GO:0002377

BP

immunoglobulin production

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

ITM2A, IL7R, FAS

GO:0002378

BP

immunoglobulin biosynthetic process

The chemical reactions and pathways resulting in the formation of immunoglobulin.

PTPRC, GALNT2

GO:0002381

BP

immunoglobulin production involved in immunoglobulin mediated immune response

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.

HLA-DQB1

GO:0002384

BP

hepatic immune response

An immune response taking place in the liver.

IL6, IL6R

GO:0002385

BP

mucosal immune response

An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.

OTUD7B

GO:0002399

BP

MHC class II protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.

HLA-DMB

GO:0002407

BP

dendritic cell chemotaxis

The movement of a dendritic cell in response to an external stimulus.

HMGB1, CCL5, CXCR2, GPR183, PIK3CG, CXCR4, ANO6, TRPM4

GO:0002408

BP

myeloid dendritic cell chemotaxis

The movement of a myeloid dendritic cell in response to an external stimulus.

ARHGEF5

GO:0002418

BP

immune response to tumor cell

An immune system process that functions in the response of an organism to a tumor cell.

MICA

GO:0002429

BP

immune response-activating cell surface receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response.

MICB

GO:0002430

BP

complement receptor mediated signaling pathway

A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway.

GPR32, CR1, FPR1, FPR2, GPLD1

GO:0002431

BP

Fc receptor mediated stimulatory signaling pathway

A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.

LYN

GO:0002432

BP

granuloma formation

The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic.

CEBPB

GO:0002437

BP

inflammatory response to antigenic stimulus

An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.

HMGB1, HMGB2, NOTCH1, IL5RA

GO:0002438

BP

acute inflammatory response to antigenic stimulus

An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

SERPINC1, ICAM1, CXCR2, CD6

GO:0002439

BP

chronic inflammatory response to antigenic stimulus

A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual.

TNF, AHCY

GO:0002446

BP

neutrophil mediated immunity

Any process involved in the carrying out of an immune response by a neutrophil.

IL6, ACE, CXCL5, ADAM17, CXCL6, KMT2E

GO:0002448

BP

mast cell mediated immunity

Any process involved in the carrying out of an immune response by a mast cell.

SERPINB9, SPON2

GO:0002455

BP

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

HLA-DQB1, BCL3, ZP3, EXO1

GO:0002456

BP

T cell mediated immunity

Any process involved in the carrying out of an immune response by a T cell.

MYO1G, BTN3A3, CD46, GNL1, BTN3A2, JAG1, FOXP3

GO:0002457

BP

T cell antigen processing and presentation

The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

ICAM1, RFTN1

GO:0002460

BP

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.

TGFB1

GO:0002467

BP

germinal center formation

The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.

BCL3, BCL6, ADAM17, MEF2C, KLHL6

GO:0002474

BP

antigen processing and presentation of peptide antigen via MHC class I

The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.

SEC24D, SEC31A, HLA-B, ACE, HLA-E, HLA-G, CALR, CANX, PDIA3, HLA-A, HLA-F, BCAP31, SEC13, B2M, SEC23A, ERAP2, MR1, ERAP1, SAR1B

GO:0002476

BP

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.

HLA-E

GO:0002479

BP

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.

PSMD11, PSMD12, PSMD3, PSMD10, HLA-B, CYBB, ITGAV, FCGR1A, HLA-E, CD36, HLA-G, PSMC3, ITGB5, NCF2, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, HLA-A, HLA-F, PSMC2, PSMB10, PSMC4, PSMB3, PSMD7, PSME3, B2M, PSMC1, PSMC6, PSMD2, PSME4, NCF4, FCGR1B

GO:0002480

BP

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules.

HLA-B, HLA-E, HLA-G, HLA-A, HLA-F, B2M, LNPEP

GO:0002481

BP

antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.

B2M

GO:0002495

BP

antigen processing and presentation of peptide antigen via MHC class II

The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.

MARCH8, MARCH1

GO:0002502

BP

peptide antigen assembly with MHC class I protein complex

The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules.

CALR

GO:0002503

BP

peptide antigen assembly with MHC class II protein complex

The binding of a peptide to the antigen binding groove of an MHC class II protein complex.

HLA-DRA, HLA-DMB

GO:0002504

BP

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.

HLA-DRA

GO:0002506

BP

polysaccharide assembly with MHC class II protein complex

The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex.

HLA-DRA

GO:0002513

BP

tolerance induction to self antigen

Tolerance induction directed at self antigens.

TGFB1, LYN, FOXP3

GO:0002520

BP

immune system development

The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

TROVE2, SMAD3, CACNA1C

GO:0002521

BP

leukocyte differentiation

The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.

RRAS

GO:0002523

BP

leukocyte migration involved in inflammatory response

The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.

PPBP, ITGB2, S100A8, S100A9, CCL2, SELE, ADAM8, JAM3

GO:0002526

BP

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

PTGES, NUPR1, VNN1, APOA2, S100A8, B4GALT1, VCAM1, TNFSF4, ACVR1

GO:0002532

BP

production of molecular mediator involved in inflammatory response

The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.

IL4R

GO:0002534

BP

cytokine production involved in inflammatory response

The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.

SEH1L

GO:0002537

BP

nitric oxide production involved in inflammatory response

The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.

TLR4, SLC7A2

GO:0002540

BP

leukotriene production involved in inflammatory response

The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.

ALOX5

GO:0002543

BP

activation of blood coagulation via clotting cascade

Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot.

ANO6

GO:0002544

BP

chronic inflammatory response

Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.

PTGES, VNN1, S100A8, THBS1, GJA1, VCAM1

GO:0002548

BP

monocyte chemotaxis

The movement of a monocyte in response to an external stimulus.

TNFSF11, PDGFB, ANXA1, IL6, IL6R, CCL3, CCL4, CCL2, CCL5, LGALS3, CCL20, CCL8, PTPRO, TNFRSF11A

GO:0002551

BP

mast cell chemotaxis

The movement of a mast cell in response to an external stimulus.

PIK3CD, KIT, RAC1

GO:0002553

BP

histamine secretion by mast cell

The regulated release of histamine by a mast cell or group of mast cells.

SNAP23, LYN

GO:0002554

BP

serotonin secretion by platelet

The regulated release of serotonin by a platelet or group of platelets.

SYK

GO:0002573

BP

myeloid leukocyte differentiation

The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.

HHEX

GO:0002576

BP

platelet degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.

ISLR, ABCC4, ACTN4, WDR1, PHACTR2, F8, F13A1, PLG, SERPINA1, SERPINA3, A2M, TIMP1, KNG1, PDGFB, TGFB1, IGF2, APOA1, FGA, FGB, FGG, APOH, FN1, ORM1, AHSG, ALB, PPBP, PF4, TF, ALDOA, PDGFA, A1BG, VWF, IGF1, APP, ITGB3, SERPINE1, SERPING1, CLEC3B, PSAP, LYN, THBS1, SPARC, SRGN, CLU, F5, ACTN1, LAMP2, HGF, VEGFA, PECAM1, CD36, ORM2, FLNA, CD9, ACTN2, TIMP3, VEGFB, VEGFC, SEPP1, STXBP1, TGFB2, CALM2, TMSB4X, TUBA4A, APLP2, SPP2, MMRN1, GAS6, HABP4, TTN, FAM3C, RARRES2, TLN1

GO:0002581

BP

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.

THBS1

GO:0002587

BP

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.

HLA-DOB

GO:0002588

BP

positive regulation of antigen processing and presentation of peptide antigen via MHC class II

Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.

PYCARD