GO:0030099

BP

myeloid cell differentiation

The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.

BCL6, CDKN1C, PRKX, TIRAP, ZBTB16, CBFB, IFI16, KAT6A

GO:0030100

BP

regulation of endocytosis

Any process that modulates the frequency, rate or extent of endocytosis.

BIN1, RAB5A, ABL2, TSC2, RAB5C, AP2S1, CDH13, RAB4B, RAB5B, PICALM, ZFYVE16, PACSIN1, EHD4, SNX12, STON1

GO:0030101

BP

natural killer cell activation

The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.

PIK3CD, ITGB2, IL18R1, IL18, CASP8, ULBP3, ULBP2

GO:0030103

BP

vasopressin secretion

The regulated release of vasopressin from secretory granules into the blood.

TRPV4

GO:0030104

BP

water homeostasis

Any process involved in the maintenance of an internal steady state of water within an organism or cell.

AQP9, NEDD4L

GO:0030111

BP

regulation of Wnt signaling pathway

Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.

PLPP3, SNX3, ITGA3, PPP2R1A, STK11, TCF7L1, DCDC2

GO:0030148

BP

sphingolipid biosynthetic process

The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

ELOVL7, PLPP1, PLPP3, SPTLC2, VAPB, ALDH3B2, ALDH3A2, PRKD1, HACD4, HACD2, CERS6, FA2H, SGMS1, SGPP2, CERS5, SPTSSB, SGMS2, ELOVL1, ELOVL4, ELOVL6, CERS4, SPHK1, ELOVL5, HACD3, VAPA

GO:0030149

BP

sphingolipid catabolic process

The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

PPT1

GO:0030150

BP

protein import into mitochondrial matrix

The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.

TIMM23, TIMM17B, TOMM40, TOMM20, TIMM50, TIMM17A, TIMM21, GRPEL1, TOMM22, TOMM7, PAM16

GO:0030154

BP

cell differentiation

The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

DAPL1, SH3PXD2B, WIPF3, HIP1, FOXN3, ITGB1BP1, MUSK, TGFB1I1, PAX4, SOX15, CREBL2, JAK2, GAS7, GADD45B, CSPG5, GADD45G, ZBTB7A, EYA4, CLPTM1, RAF1, TP53, INHA, FYN, INHBA, MGP, INHBB, FGR, MYBL1, MYBL2, TDGF1, TPT1, ETS2, SRD5A1, ELK1, TYMP, NR1D1, MAK, MAL, MDK, JAK1, YY1, ARNT, CTGF, SRD5A2, AKT1, FOXN2, STX2, COL15A1, ETV5, CSK, ADCYAP1R1, ELK3, PRRC2A, CENPF, PGF, ERF, FXR1, FOXL2, RPS3A, RPS7, RHOB, SRPK2, DLK1, SIM1, FOXK1, PURA, SLC7A5, HHEX, CREM, GNA12, TNFAIP2, PPARD, GABPA, TNK2, SLFN5, MAPK7, UBE2V1, GPM6B, SQSTM1, FHL1, SIM2, ELAVL3, ZNF268, ANGPT1, SHB, CCDC85B, ADIRF, ZIC1, CSRP2, DUSP6, ZNF423, TMEM176B, MORN2, HERC4, PRRC2B, SFRP5, COL13A1, SFRP4, STYK1, ALKBH5, CPLX2, NHS, SLCO4C1, ILDR2, NOTCH2NL, PIWIL4, ARHGAP22, HUWE1, ZSCAN2, PEG10, CAND1, SPATA24, GPSM1, RBM45, ARHGEF28, ARHGAP24, EID2, TDRD9, OSR1, SPATA20, AGR3, SLC2A14, ABHD5, EDARADD, EXT2, PBXIP1, FAM120B, DAZAP1, HES6, KAZALD1, GMCL1, APOLD1, UHRF2, PURB, ATOH8, CDC5L, MMP19, CITED2, HTATIP2, RBM4, SPATA9, RBM24, NAA15, TEX15, CADM1, RBM38, SUV39H2, USP42, BEX1, HES4, SRA1, PDLIM7, PARP11, GLRX2, ASF1B, ZAK, THEG, DHCR7, TUBD1, OSGIN1, ELF5, ZHX1, TCFL5, MYT1L, NDRG4, PLAGL1, NDRG2, THSD7A, SH2B3, RNF114, EID1, BZW2

GO:0030155

BP

regulation of cell adhesion

Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.

PPP1R12A, NUAK1, ROCK2, ICAM1, CXCL8, PRLR, S1PR1, LAMA2, PPP2R1A, ABL2, SOX9, PRKX, PPP1CB, PKD1, PTPRJ, IL18, KIF14, LAMA4, LAMA3, CBLL1, PKP4, SERPINI1, FAF1

GO:0030157

BP

pancreatic juice secretion

The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.

SCT, NPR3, COPA

GO:0030162

BP

regulation of proteolysis

Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

GSAP, SERPINB4, PLAUR, SPOPL, ABTB2, BTBD9, KBTBD4, SERPINB13, BTBD3

GO:0030163

BP

protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

TPP1, CLN5, AMBP, CTSD, UCHL3, AKT1, PPT1, CLN3, SIAH1, CLN6, LNPEP

GO:0030166

BP

proteoglycan biosynthetic process

The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.

IGF1, BMPR2, CSGALNACT1

GO:0030167

BP

proteoglycan catabolic process

The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.

ADAMTS12

GO:0030168

BP

platelet activation

A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.

PLSCR1, FZD6, F8, F2, COL1A1, COL3A1, PF4, RAF1, VWF, ITGB3, IL6, PRKCB, FYN, LYN, COL1A2, SAA1, F5, GP1BB, RAC2, VAV1, PLCG2, PRKCA, ADRA2B, FLNA, CD9, F2R, MAPK3, PIK3R1, MAPK1, CD40LG, GNA11, AKT1, PIK3CA, PIK3CB, SYK, PIK3CG, GNAQ, RAP2B, RHOA, RHOB, GNB1, RAC1, YWHAZ, GNA12, PRKCQ, PRKCD, PTPN11, TYRO3, MERTK, TRPC3, DGKZ, GAS6, ITPR2, ITPR3, ITPR1, DGKK, BLOC1S3, DGKH, PDPN, VAV3, TRPC6

GO:0030174

BP

regulation of DNA-dependent DNA replication initiation

Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.

NBN, CDT1

GO:0030177

BP

positive regulation of Wnt signaling pathway

Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.

TLR2, BMP2, SKI, FGFR2, SMARCA4, WNT3, HHEX, SOX4, KANK1, WLS, SULF2, SULF1, SFRP1, ATP6V1C2, DEPDC1B, RSPO3, LGR6, DACT1, ZRANB1, MACF1, SPIN1

GO:0030178

BP

negative regulation of Wnt signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.

TAX1BP3, AXIN1, DKK1, NFATC1, FGF9, CSNK1E, TSC2, RACK1, TLE1, GRB10, NFATC4, SFRP5, SFRP4, SHISA2, TRABD2A, APCDD1, SFRP1, MED12, DACT3, MDFI, CITED1, CHD8, DACT1, NLK, HMGXB4, WIF1

GO:0030182

BP

neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron.

DAPK3, FZD7, ALDH1A2, WNT2, CEBPB, S1PR1, PTPRD, SMARCA1, PPP1CC, ID1, WNT5A, WNT3, MTPN, CDK5, ID3, MAP2K1, EMX2, MEF2C, RUNX2, NTRK2, ADNP2, PAPD4, NLGN4X, GPC2, PCSK9, PROX1, WNT2B, PIGT, IER2, NIF3L1, WNT5B, HIPK2, FZD8, NGRN, NRBP2, DDIT4, MYEF2, HDAC9, FZD4, HDAC5, TRPC6, WNT6

GO:0030183

BP

B cell differentiation

The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.

IFNA1 , NTRK1, IFNA16, ITGB1, RAG1, TCF3, PLCG2, PTPN2, VCAM1, IL11, IL10, PIK3R1, CD40LG, BCL6, MSH2, JAK3, CEBPG, TPD52, HDAC4, ADAM17, SP3, HHEX, EP300, GON4L, IFNE, BLNK, DCLRE1C, KLF6, CLCF1, HDAC9, HDAC5

GO:0030185

BP

nitric oxide transport

The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

EDN1, HBB

GO:0030193

BP

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

F2, F2R, STX2, F2RL1, CAV1, ASIC2, STXBP5, STAB2, FAM46A

GO:0030194

BP

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

F2, APOH, SERPINE1, S100A9, THBS1, CD36, F2R, HPSE, ENPP4

GO:0030195

BP

negative regulation of blood coagulation

Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.

KNG1, APOE, APOH, VTN, SERPINE1, EDN1, SERPINE2, TSPAN8

GO:0030198

BP

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TNFRSF11B, CYR61, NCAN, DNAJB6, ITGA10, ECM2, RECK, PDGFB, TNF, COL1A1, COL3A1, FGA, FGB, FGG, FN1, TTR, VTN, PDGFA, VWF, APP, ITGB3, ITGB2, SERPINE1, ICAM1, ITGB1, COL5A2, ITGAV, DCN, LAMB1, THBS1, COL1A2, COL4A2, ITGA5, FGF2, SPARC, FURIN, SPP1, HAPLN1, LAMC1, ITGAM, COL11A1, COL6A1, COL6A2, COL6A3, VCAN, NID1, B4GALT1, CD44, ITGB4, PECAM1, ITGA2, ERCC2, ITGB5, VCAM1, ITGAX, BCL3, COL9A1, COL5A1, BGN, FBLN1, ITGA6, LAMA2, TNC, COL8A2, COL5A3, ITGA3, ITGB8, LOX, FBN1, FBN2, BSG, SERPINB5, ITGAE, COL18A1, SOX9, COMP, LUM, MFAP2, JAM2, ADAMTS20, ELF3, HSPG2, COL4A3, COL10A1, PTK2, COL14A1, COL16A1, DDR1, LOXL1, CD47, PRDX4, MFAP5, ITGA9, COL4A6, NID2, DAG1, POSTN, TGFBI, LAMA4, LAMA3, HSD17B12, COL13A1, OLFML2A, ADAMTSL4, CCDC80, NPHP3, ERO1B, TMPRSS6, NDNF, CSGALNACT1, SPOCK2, TNR, APBB2, BCAN, ERO1A, KAZALD1, JAM3, CRISPLD2, SMOC2, DSPP, ITGA11, HPSE, F11R, POMT1, LAMC3

GO:0030199

BP

collagen fibril organization

Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.

GREM1, COL1A1, COL3A1, COL5A2, ANXA2, COL1A2, COL11A1, P4HA1, COL11A2, COL5A1, TNXB, MMP11, COL5A3, LOX, TGFBR1, SERPINH1, LUM, TGFB2, COL14A1, FMOD, FOXC1, CYP1B1, COL12A1, LOXL2

GO:0030200

BP

heparan sulfate proteoglycan catabolic process

The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.

GPC1, SGSH, HPSE

GO:0030201

BP

heparan sulfate proteoglycan metabolic process

The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.

SULF2, SULF1

GO:0030203

BP

glycosaminoglycan metabolic process

The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties.

NCAN, SDC3, GPC4, CSPG5, DCN, VCAN, SDC1, BGN, SDC4, SDC2, GPC1, HSPG2, FOXC1, CSPG4, GPC2, BCAN, CLN6, GPC6

GO:0030204

BP

chondroitin sulfate metabolic process

The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.

DSEL

GO:0030206

BP

chondroitin sulfate biosynthetic process

The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.

NCAN, CSPG5, DCN, VCAN, BGN, CSPG4, CHSY3, CHST15, CHST3, CHSY1, CSGALNACT1, BCAN, XYLT2, CHST11, CHST7, SLC35D1, DSE

GO:0030207

BP

chondroitin sulfate catabolic process

The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.

NCAN, CSPG5, HEXA, DCN, VCAN, ARSB, BGN, CSPG4, BCAN

GO:0030208

BP

dermatan sulfate biosynthetic process

The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.

NCAN, CSPG5, DCN, VCAN, BGN, CSPG4, DSEL, BCAN, DSE

GO:0030210

BP

heparin biosynthetic process

The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

NDST1, ANGPT1, CSGALNACT1, XYLT2

GO:0030212

BP

hyaluronan metabolic process

The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.

HGF, AKT1, MKI67, ITIH5

GO:0030213

BP

hyaluronan biosynthetic process

The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.

ABCC5, IL1B, CEMIP, HAS2

GO:0030214

BP

hyaluronan catabolic process

The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.

HMMR, TGFB1, HEXA, FGF2, CD44, HYAL2, CEMIP, STAB2, CHP1, LYVE1

GO:0030216

BP

keratinocyte differentiation

The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.

IRF6, EREG, LATS1, CSTA, ANXA1, KRT16, DSP, S100A7, SPRR2B, WNT5A, AKR1C3, NOTCH1, YAP1, JAG1, MAP2K1, POU3F1, STK4, ADAM9, SPRR2G, TXNIP, LATS2, SPRR3, INTU

GO:0030217

BP

T cell differentiation

The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.

PIK3CD, CD4, PTPRC, KIT, VAV1, IL7R, PTPN2, EGR1, LEP, LEPR, SP3, SOX4, RUNX2, PATZ1, DLL4, CHD7, PTPN22

GO:0030218

BP

erythrocyte differentiation

The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.

JAK2, INHA, LYN, INHBA, KIT, THRA, BMP4, HCLS1, TAL1, PTPN2, RPS14, IKZF1, NFE2L1, KMT2E, SMAD5, EPAS1, HIPK2, SFXN1

GO:0030219

BP

megakaryocyte differentiation

The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.

TAL1, IL11, CDKN2B, SP3

GO:0030220

BP

platelet formation

The process in which platelets bud from long processes extended by megakaryocytes.

ACTN1, TAL1, MYH9, CASP9, PTPN11, MEF2C, EP300, CIB1

GO:0030221

BP

basophil differentiation

The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell.

TAL1

GO:0030224

BP

monocyte differentiation

The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.

JUN, CSF1R, BMP4, MT1G, VEGFA, MYH9, PPARG, SP3, MEF2C, IFI16

GO:0030225

BP

macrophage differentiation

The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.

CSF1R, PARP1, BMP4, MMP9, VEGFA, CDC42, CASP8, GAB3, L3MBTL3

GO:0030238

BP

male sex determination

The specification of male sex of an individual organism.

DHH, GNRH1, INSR, FGF9, NR0B1, PTGDR

GO:0030239

BP

myofibril assembly

Formation of myofibrils, the repeating units of striated muscle.

CAPN3, TMOD1, LMOD1, MYOZ1

GO:0030240

BP

skeletal muscle thin filament assembly

The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle.

ACTC1, TTN, PROX1

GO:0030241

BP

skeletal muscle myosin thick filament assembly

The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle.

MYH11, TTN

GO:0030242

BP

pexophagy

The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions.

ACBD5, RB1CC1, PIK3R4

GO:0030252

BP

growth hormone secretion

The regulated release of growth hormone from secretory granules into the blood.

GHRH, RAB1A, CDK16, GHSR, GHRL

GO:0030258

BP

lipid modification

The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid.

FA2H

GO:0030260

BP

entry into host cell

The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.

CD4, CXCR4, PPIA

GO:0030261

BP

chromosome condensation

The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

AIFM1, CDK1, HMGA2, NCAPG2

GO:0030262

BP

apoptotic nuclear changes

Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.

BLCAP

GO:0030263

BP

apoptotic chromosome condensation

The compaction of chromatin during apoptosis.

TOP2A, GPER1

GO:0030264

BP

nuclear fragmentation involved in apoptotic nuclear change

The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.

TARDBP, GPER1

GO:0030277

BP

maintenance of gastrointestinal epithelium

Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.

SERPINA3, RBP4, PBLD, MUC4, MUC13

GO:0030278

BP

regulation of ossification

Any process that modulates the frequency, rate or extent of bone formation.

DHRS3, EGR2, MAPK3, MAPK1, PTGER4, PBX1, ACVR1, MAPK14, INTU

GO:0030279

BP

negative regulation of ossification

Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation.

SMAD6, TGFB1, BCL2, NOTCH1, SOX9, MEF2C, CHSY1, SFRP1, SOST

GO:0030282

BP

bone mineralization

The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.

CYP27B1, BGLAP, CLEC3B, BMP2, ALOX15, ERCC2, FGFR2, PTGS2, KLF10, GPNMB, LGR4, FBXL15, DUOX2, MINPP1, SBDS

GO:0030299

BP

intestinal cholesterol absorption

Uptake of cholesterol into the blood by absorption from the small intestine.

LDLR, CD36, AKR1C1, ABCG8

GO:0030300

BP

regulation of intestinal cholesterol absorption

Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption.

APOA1, APOA2, LEP, APOA5

GO:0030301

BP

cholesterol transport

The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

NPC1, VPS4B, LDLR, APOA1, APOB, CFTR, CD36, NPC2, CAV1

GO:0030302

BP

deoxynucleotide transport

The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell.

SLC25A19

GO:0030307

BP

positive regulation of cell growth

Any process that activates or increases the frequency, rate, extent or direction of cell growth.

SDCBP, DDX3X, ADAM10, PSMD10, EGFR, F2, INS, ERBB2, S100A8, S100A9, IGFBP1, BCL2, AKT1, SFN, TGFBR1, MMP14, MTPN, CDC42, TGFB2, ADAM17, H3F3A, IL9R, KRT17, EXOSC9, NCBP1, AKAP6, MAP2K5, EXOSC2, RPS6KA1, FXN, ADNP2, NOL8, SUPV3L1, SFRP1, HBEGF, CIB1, DERL2, CXCL16, TAF9B, EXOSC4, CDKN2AIP, SPHK1, ZNF639, N6AMT1

GO:0030308

BP

negative regulation of cell growth

Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

APBB1, DDX3X, CYP27B1, GDF9, GREM1, NME6, SLIT2, BMP10, AGT, TGFB1, CRYAB, TP53, ENO1, SERPINE2, INHBA, FBP1, BCL2, NPPB, GJA1, WT1, ENPP1, MT3, PPP2R1A, PHB, ACVR1B, PPARG, CDKN1A, BCL6, CDKN2C, CDKN1B, AGTR2, GNG4, PPT1, SMARCA2, SMARCA4, SESN2, TGFB2, BTG1, RACK1, SMAD3, FOXK1, PPARD, BST2, HYAL2, PTPRJ, SMAD4, FHL1, BMPR2, STK11, CCDC85B, JADE1, PSRC1, ADIPOR2, CRLF3, CCAR2, SFRP1, FLCN, ESR2, APBB2, ADIPOR1, RERG, DACT3, DCBLD2, TSPYL2, SOX17, WFDC1, RTN4, CDKN2AIP, NDUFA13, SH3BP4, IP6K2, OSGIN1

GO:0030311

BP

poly-N-acetyllactosamine biosynthetic process

The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.

B4GAT1, B3GNT2

GO:0030316

BP

osteoclast differentiation

The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

TNFSF11, FARP2, TNF, TFRC, CSF1R, JUNB, GPR183, CTNNB1, GLO1, MAPK14, OSTM1, FOXP1, TNFRSF11A

GO:0030317

BP

flagellated sperm motility

Any process involved in the controlled movement of a flagellated sperm cell.

ADCY3, APOB, ATP2B4, DNAJA1, CHRNA7, TMF1, SORD, DNAH5, DNAH11, SLIRP, DNAH1, DNAI1, TEKT2

GO:0030318

BP

melanocyte differentiation

The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.

MITF, GLI3, BCL2, KIT, RAB27A, MEF2C, USP13, CITED1, C10orf11, HPS4, BLOC1S6, MYO5A

GO:0030321

BP

transepithelial chloride transport

The directed movement of chloride ions from one side of an epithelium to the other.

BEST1, SLC12A2

GO:0030322

BP

stabilization of membrane potential

The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

KCNK1, KCNK3, KCNK17, KCNK12, KCNK6

GO:0030323

BP

respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.

PCSK5, HECA

GO:0030324

BP

lung development

The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.

FGF18, ALDH1A2, EGFR, RBP4, MYCN, EIF4E, SPARC, WNT2, GLI2, GLI3, VEGFA, FGFR2, ITGA3, LOX, HSD11B1, CTGF, NOS3, CHI3L1, BMPR1A, SREBF1, LIPA, WNT5A, NKX2-1, NOTCH1, MMP14, HRSP12, PPP1CA, SP3, EP300, EIF4EBP1, ACVR2B, SIM2, HES1, TAB1, SMAD2, JMJD6, CCBE1, NPHP3, PDPN, ZFPM2, PROX1, EPAS1, CRISPLD2, DHCR7, HEG1, TIMELESS, HSPB11

GO:0030325

BP

adrenal gland development

The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.

APOA1, INSR, WT1, MDK, TSPO, PBX1, CDKN1C, NR0B1, ARID5B, DKK3

GO:0030326

BP

embryonic limb morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.

GREM1, DKK1, FGFR1, SKI, HOXD10, HOXA10, FGF9, FBN2, GJA5, PBX1, PBX2, GDF5, PSEN1, DLX5, TGFB2, PTCH1, FRAS1, ACD, MBNL1, CYP26B1

GO:0030327

BP

prenylated protein catabolic process

The chemical reactions and pathways resulting in the breakdown of prenylated proteins.

PCYOX1

GO:0030328

BP

prenylcysteine catabolic process

The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.

PCYOX1

GO:0030329

BP

prenylcysteine metabolic process

The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.

PCYOX1

GO:0030330

BP

DNA damage response, signal transduction by p53 class mediator

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.

MDM4, FOXO3, TRIAP1, NBN, TP53, MIF, BCL3, ATRX, SESN2, NDRG1, MYO6

GO:0030334

BP

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

PLXNB2, LDB2, PLXNC1, PLXNA2, UNC5C, TGFB1, LMNA, SERPINE2, MMP10, FLNA, LAMA2, AKT1, AKT2, PLXNA3, PRKX, CXCR4, RHOA, LMO4, RHOB, RAC1, JAG1, CDK5, NEXN, GAB1, ENPP2, KIF14, ERBB4, LAMA4, LAMA3, AMOT, PHLDA2, HACE1, MINK1, SGK3, DOCK10, AJUBA, SPATA13, PITX2, PARD6B, TBCCD1, PLXNA1, PLXND1

GO:0030335

BP

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

WASH1, MYO1C, RHOD, PIK3CD, SDCBP, CYR61, ADAM10, SEMA3E, DAPK3, SNAI2, ACTN4, SPAG9, JAK2, SEMA7A, SEMA3D, IKBKAP, EGFR, PLAU, PDGFB, TGFB1, CGA, FSHB, INS, COL1A1, PDGFA, IGF1, EDN1, INSR, ITGAV, CSF1R, LAMB1, LYN, THBS1, IGF1R, ITGA5, PDGFRB, CTSH, FGR, CCL3, KIT, HSPA5, BMP2, TDGF1, CCL5, HGF, VEGFA, PDGFRA, PRKCA, XBP1, S1PR1, ITGA6, APC, F2R, PIK3R1, MAPK1, SERPINB3, CORO1A, AKT2, RDX, TGFBR1, COL18A1, MCAM, NOTCH1, NUMB, MMP14, F2RL1, CDH13, RRAS2, RACK1, ADAM17, SMAD3, TNFAIP6, DAB2, INSM1, ACVR1, PTK2, ELP6, STX4, TIAM1, SEMA3B, ILK, SEMA5A, ZNF268, TRIP6, MAPRE1, MYLK, FAM110C, LRRC16A, FAM83H, CBLL1, RUFY3, CCAR1, GCNT2, ARHGEF39, SEMA6D, CEMIP, SYNE2, HAS2, PTP4A1, MYADM, HBEGF, GPER1, CIB1, SEMA3C, PDCD10, PDGFD, WNT5B, CXCL16, SEMA4A, SEMA6B, ELP3, LGR6, PDGFC, SPHK1, GTSE1, SUN2, IRS2

GO:0030336

BP

negative regulation of cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.

SMAD7, SLIT2, BMP10, RECK, SERPINE1, KRT16, TPM1, RAP2A, RRAS, BCL2, IFITM1, DRD2, IGFBP5, NF2, TIE1, NKX2-1, STC1, PTEN, RAP2B, RHOB, ADARB1, BST2, PTPRJ, DAG1, DPYSL3, KANK1, PTPRK, ADIPOQ, CYP1B1, PODN, SRGAP1, ARPIN, MAGI2, SULF1, SFRP1, FLCN, ARAP3, TP53INP1, DLC1, PKP2, CITED2, ABHD6, OSBPL8, FAM60A, DACH1, TMEFF2, NISCH, TCAF1, STK24

GO:0030388

BP

fructose 1,6-bisphosphate metabolic process

The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.

FBP2, ALDOA, FBP1, ALDOC, PFKL

GO:0030421

BP

defecation

The expulsion of feces from the rectum.

MDK

GO:0030422

BP

production of siRNA involved in RNA interference

Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.

PRKRA, MRPL44, DICER1

GO:0030423

BP

targeting of mRNA for destruction involved in RNA interference

The process in which small interfering RNAs target cognate mRNA molecules for degradation.

DICER1

GO:0030431

BP

sleep

Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.

FOS, DLAT, OXTR, GRIN2A, PTGDR, IL18, SLC29A1

GO:0030432

BP

peristalsis

A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.

DRD2, DLG1

GO:0030433

BP

ER-associated ubiquitin-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins.

TMEM129, UBXN8, RNF103, TRIM13, ERLIN2, HSPA5, HSP90B1, PSMC3, PSMC2, PSMC4, VCP, PSMC1, PSMC6, OS9, SYVN1, DNAJC10, UBE2J2, STT3B, EDEM1, CCDC47, FAF2, VIMP, EDEM3, DERL2, RNF121, JKAMP, DNAJB9, SEL1L, MAN1B1, AMFR

GO:0030449

BP

regulation of complement activation

Any process that modulates the frequency, rate or extent of complement activation.

CFB, C3, VTN, CFI, C8G, CD55, CFH, C4A, C4B, C7, C6, CD46, CR1, C5AR1, CFP, C1QBP, SUSD4

GO:0030472

BP

mitotic spindle organization in nucleus

A process resulting in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle in the nucleus. The process occurs during a mitotic cell cycle and takes place at the cellular level.

PPP2R4

GO:0030488

BP

tRNA methylation

The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.

NSUN2, METTL2B, GTPBP3, METTL2A, TRMO, THUMPD3, TRMT13, TRMT6

GO:0030490

BP

maturation of SSU-rRNA

Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.

SNU13, RPS14, LSM6, UTP4, NOL11, TSR3, NOB1

GO:0030497

BP

fatty acid elongation

The elongation of a fatty acid chain by the sequential addition of two-carbon units.

HACD4, HACD2, HACD3

GO:0030500

BP

regulation of bone mineralization

Any process that modulates the frequency, rate or extent of bone mineralization.

CYP27B1, AHSG, BGLAP, MGP, GJA1, S1PR1, ENPP1, NBR1, TWIST1, OMD, ANKH, BMP2K, TXLNG

GO:0030501

BP

positive regulation of bone mineralization

Any process that activates or increases the frequency, rate or extent of bone mineralization.

TGFB1, PTH, ADRB2, BMP2, BMP4, BMP6, ACVR2A, FBN2, BMPR1A, SMAD3, ACVR1, MEF2C, GPM6B, ACVR2B, BMPR2, ANO6, CD276, FAM20C, OSR1, KL