GO:0001947

BP

heart looping

The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.

MICAL2, FOLR1, GJA1, TGFBR2, WNT5A, GATA4, NOTCH1, PSEN1, SMAD3, MEF2C, PKD2, TMED2, STIL, HIF1A, NPHP3, MIB1, CCDC103, BBS7, AHI1, SETDB2, SOX17, MKKS, NDRG4, SUFU

GO:0001949

BP

sebaceous gland cell differentiation

The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell.

FA2H

GO:0001951

BP

intestinal D-glucose absorption

Uptake of D-glucose into the blood by absorption from the small intestine.

EZR, PLS1

GO:0001952

BP

regulation of cell-matrix adhesion

Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.

BCL2, PIK3CB, DDR1, MINK1

GO:0001953

BP

negative regulation of cell-matrix adhesion

Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.

CASK, SEMA3E, THBS1, RASA1, PIK3R1, NF2, BCL6, POSTN

GO:0001954

BP

positive regulation of cell-matrix adhesion

Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.

CD36, VEGFC, GSK3B, EMP2, CDH13, CDK6, ILK, SFRP1, CIB1, PLEKHA2

GO:0001955

BP

blood vessel maturation

A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.

RECK, MMP2, S1PR1, CDH5, DDIT3

GO:0001956

BP

positive regulation of neurotransmitter secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.

SNCA, GPER1

GO:0001957

BP

intramembranous ossification

Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.

FGF18, COL1A1, MMP2, CTSK, MN1

GO:0001958

BP

endochondral ossification

Replacement ossification wherein bone tissue replaces cartilage.

FGF18, COL1A1, ALPL, BMP4, BMP6, MMP14, MMP16, DLX5, GNAS, TEK, COL10A1, MEF2C, RUNX2, MEF2D, GNAS, COL13A1, CSGALNACT1

GO:0001959

BP

regulation of cytokine-mediated signaling pathway

Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.

IRAK2, CD24, IRAK1

GO:0001960

BP

negative regulation of cytokine-mediated signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.

PTPRC, CAV1, SIGIRR, IRAK3

GO:0001961

BP

positive regulation of cytokine-mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.

RIPK2, CD74, GAS6

GO:0001963

BP

synaptic transmission, dopaminergic

The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.

TH, DRD2, CDK5, RASD2

GO:0001964

BP

startle response

An action or movement due to the application of a sudden unexpected stimulus.

PARK2, PENK, GLRB, NRG1, KCNA1, GRIN2A

GO:0001966

BP

thigmotaxis

The directed movement of a motile cell or organism in response to touch.

ID2

GO:0001967

BP

suckling behavior

Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast.

GLS, APP, OXTR, UBR3, DERL2, DACH1

GO:0001970

BP

positive regulation of activation of membrane attack complex

Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.

C3, C6

GO:0001973

BP

adenosine receptor signaling pathway

The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.

GNAI2, ADORA2B, ADORA1

GO:0001974

BP

blood vessel remodeling

The reorganization or renovation of existing blood vessels.

HOXA3, NOL3, AGT, ACE, LIF, BGN, TGM2, NOS3, AGTR2, TGFB2, JAG1, MDM2, MEF2C, BAX, FOXC1, ACVR2B, BMPR2, EPAS1, SEMA3C, RSPO3, DLL4, CHD7

GO:0001975

BP

response to amphetamine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.

ICAM1, TH, DRD2, OXTR, NR4A2, RANBP2, CALM2, SLC18A2, PPP3CA, GRIN2A, HDAC1, DPYSL2, HDAC2, HDAC9

GO:0001976

BP

neurological system process involved in regulation of systemic arterial blood pressure

The regulation of blood pressure mediated by detection of stimuli and a neurological response.

DRD2

GO:0001980

BP

regulation of systemic arterial blood pressure by ischemic conditions

The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system.

TNNI3

GO:0001985

BP

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure.

ADRA1A

GO:0001988

BP

positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure

Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure.

CHRNA7

GO:0001991

BP

regulation of systemic arterial blood pressure by circulatory renin-angiotensin

The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.

AGTR2

GO:0001992

BP

regulation of systemic arterial blood pressure by vasopressin

The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport.

AVPR2, OXTR

GO:0001994

BP

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure.

ADRA1D, ADRA1A, ADRA1B

GO:0001996

BP

positive regulation of heart rate by epinephrine-norepinephrine

The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction.

ADRB1, ADRA1A

GO:0001997

BP

positive regulation of the force of heart contraction by epinephrine-norepinephrine

Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings.

ADRB1, ADRA1A

GO:0002001

BP

renin secretion into blood stream

The regulated release of renin into the blood stream by juxtoglomerular cells.

PCSK5

GO:0002003

BP

angiotensin maturation

The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood.

AGT, MME, ACE, CTSZ

GO:0002005

BP

angiotensin catabolic process in blood

The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood.

ACE

GO:0002009

BP

morphogenesis of an epithelium

The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.

CA2, KRT16, SERPINB5, FRAS1, TIMELESS

GO:0002011

BP

morphogenesis of an epithelial sheet

The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.

JAG1, DAG1, MPP5, LIN7C

GO:0002016

BP

regulation of blood volume by renin-angiotensin

The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood.

AGT

GO:0002017

BP

regulation of blood volume by renal aldosterone

The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume.

CYP11B2, HSD11B2

GO:0002018

BP

renin-angiotensin regulation of aldosterone production

The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.

AGT, AGTR1, AGTR2

GO:0002019

BP

regulation of renal output by angiotensin

The process in which angiotensin directly modulates the rate of urine output by the kidney.

AGT, ACE

GO:0002021

BP

response to dietary excess

The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.

APOE, LEP, TBL1XR1, PPARGC1A

GO:0002024

BP

diet induced thermogenesis

The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.

ADRB2, ADRB1, ADRB3, MC4R, BMP8A, TRPV1, OMA1, TRPV4, CLIC5

GO:0002025

BP

vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure

A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change.

ADRB2, ADRB1, ADRB3

GO:0002026

BP

regulation of the force of heart contraction

Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.

GAA, MYL4, ATP2A2, PLN, ADM, ATP1A2, CAMK2D, APLN

GO:0002027

BP

regulation of heart rate

Any process that modulates the frequency or rate of heart contraction.

AGT, DMD, DRD2, PRKACA, CALM2, MDM2, ANK2, PDE4D, SNTA1, SEMA3A, BVES, RYR2, EPAS1, POPDC2, RANGRF

GO:0002028

BP

regulation of sodium ion transport

Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

PER1, TGFB1, ADRB2, DRD2, NOS3, SIK1, YWHAH, DMPK, NKAIN1, NKAIN2, P2RX4, SPTBN4, WNK1

GO:0002031

BP

G-protein coupled receptor internalization

The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle.

DRD2, ADM, HTR2B, GTF2H2

GO:0002032

BP

desensitization of G-protein coupled receptor protein signaling pathway by arrestin

The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins.

ADRB2

GO:0002033

BP

vasodilation by angiotensin involved in regulation of systemic arterial blood pressure

The process that increases the size of a blood vessel via the renin-angiotensin system.

AGTR2

GO:0002034

BP

regulation of blood vessel size by renin-angiotensin

The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system.

AGT, AGTR1

GO:0002035

BP

brain renin-angiotensin system

The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system.

AGTR2, RPS6KA2

GO:0002036

BP

regulation of L-glutamate transport

Any process that modulates the frequency, rate or extent of L-glutamate transport.

SEPT2

GO:0002037

BP

negative regulation of L-glutamate transport

Any process that stops, prevents, or reduces the frequency, rate or extent of L-glutamate transport.

ARL6IP5

GO:0002038

BP

positive regulation of L-glutamate transport

Any process that activates or increases the frequency, rate or extent of L-glutamate transport.

ARL6IP1

GO:0002040

BP

sprouting angiogenesis

The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells.

E2F8, NRP1, SEMA3E, THBS1, FLT4, NOTCH1, PGF, CDH13, CDC42, TEK, ANGPT1, JMJD6, CCBE1, RSPO3, ESM1, PARVA, LOXL2

GO:0002041

BP

intussusceptive angiogenesis

The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars.

CYR61

GO:0002042

BP

cell migration involved in sprouting angiogenesis

The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.

NRP1, GREM1, SLIT2, ITGB1, FGF2, TDGF1, VEGFA, NR4A1, EFNB2, EPHB4, GPLD1, EGR3

GO:0002043

BP

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.

ITGB1BP1, BMP4, SEMA5A, BMPER

GO:0002051

BP

osteoblast fate commitment

The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.

RUNX2, SMAD1, SMAD5

GO:0002052

BP

positive regulation of neuroblast proliferation

Any process that activates or increases the rate of neuroblast proliferation.

GLI3, DRD2, VEGFA, CTNNB1, NOTCH1, VEGFC, HIF1A, SMARCD3, ASPM, ZNF335

GO:0002053

BP

positive regulation of mesenchymal cell proliferation

The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.

FOXP2, TBX1, SHOX2, LRP5, MYC, PDGFA, MYCN, WNT2, FGFR1, VEGFA, FGFR2, FGF9, CTNNB1, BMPR1A, TGFBR2, WNT5A, SOX9, IRS2

GO:0002062

BP

chondrocyte differentiation

The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.

NFIB, TGFB1, GLI2, FGFR1, BMP2, BMP4, FGF9, BMPR1A, GDF5, HMGA2, GPLD1, RUNX1, MEF2C, RUNX3, RUNX2, MEF2D, TGFBI, MAPK14, OSR1, SNX19, WNT2B, WNT5B

GO:0002063

BP

chondrocyte development

The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.

SHOX2, FGF18, COL11A1, BMPR2, RUNX2, CHSY1, SULF2, SULF1, CHST11

GO:0002064

BP

epithelial cell development

The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.

ESR1, B4GALT1, ADAMTSL4, SHROOM3

GO:0002070

BP

epithelial cell maturation

The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.

GJA1

GO:0002071

BP

glandular epithelial cell maturation

The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.

GPAT4

GO:0002072

BP

optic cup morphogenesis involved in camera-type eye development

The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.

ALDH1A3

GO:0002074

BP

extraocular skeletal muscle development

The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.

FOXL2, PITX2

GO:0002076

BP

osteoblast development

The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.

HOXA2, LRP5, BGLAP, GLI2, PTHLH, JUND, HDAC4, SMAD3, RUNX2, LIMD1

GO:0002082

BP

regulation of oxidative phosphorylation

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.

UQCC2, SLC25A23, PINK1

GO:0002084

BP

protein depalmitoylation

The removal of palymitoyl groups from a lipoprotein.

LYPLA1, LYPLA2, PPT1

GO:0002086

BP

diaphragm contraction

A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange.

GAA

GO:0002087

BP

regulation of respiratory gaseous exchange by neurological system process

A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.

GLS, ADORA1, ATP1A2, NLGN1

GO:0002088

BP

lens development in camera-type eye

The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.

CRYAB, WNT2, CDK4, GJA1, MIP, TGFBR1, TGFBR2, WNT5A, DLG1, NHS, PROX1, WNT2B, PYGO2

GO:0002089

BP

lens morphogenesis in camera-type eye

The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.

MEIS1, BCAR3, SKI, CTNNB1, SHROOM2, NECTIN1, NECTIN3

GO:0002090

BP

regulation of receptor internalization

Any process that modulates the frequency, rate or extent of receptor internalization.

FLOT1, DKK1, ARF1, SH3GL2

GO:0002091

BP

negative regulation of receptor internalization

Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization.

SDCBP, ANXA2, DLG4, MTMR2

GO:0002092

BP

positive regulation of receptor internalization

Any process that activates or increases the frequency, rate or extent of receptor internalization.

GREM1, DRD2, VEGFA, SELE, PLCG2, SYK, SYNJ2BP, FMR1, ANGPT1, SFRP4, MAGI2, AHI1, PCSK9, ATAD1, TBC1D5

GO:0002093

BP

auditory receptor cell morphogenesis

Any process that alters the size or shape of an auditory receptor cell.

RAC1

GO:0002098

BP

tRNA wobble uridine modification

The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.

IKBKAP, GTPBP3, ELP3

GO:0002115

BP

store-operated calcium entry

A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.

ORAI2, ORAI3, STIM2

GO:0002118

BP

aggressive behavior

A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual.

PENK

GO:0002138

BP

retinoic acid biosynthetic process

The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.

ALDH1A2, RBP1, ALDH1A3, RDH10, DHRS9

GO:0002143

BP

tRNA wobble position uridine thiolation

The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

TRMU

GO:0002149

BP

hypochlorous acid biosynthetic process

The chemical reactions and pathways resulting in the formation of hypochlorous acid.

MPO

GO:0002155

BP

regulation of thyroid hormone mediated signaling pathway

Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway.

THRA, NCOA1

GO:0002158

BP

osteoclast proliferation

The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.

TNFSF11, NPR3

GO:0002159

BP

desmosome assembly

A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.

JUP, PRKCA, PKP2, PKP3

GO:0002175

BP

protein localization to paranode region of axon

A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon.

EPB41L3

GO:0002181

BP

cytoplasmic translation

The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.

EIF3J, RPLP1, RPLP2, RPLP0, RPL35A, RPL7, EIF4B, RPL22, RPL29, RPL26, RPL15, RPL31, RPL36A, RPL22L1, RPL36

GO:0002184

BP

cytoplasmic translational termination

The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.

GSPT1

GO:0002188

BP

translation reinitiation

A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.

EIF3A

GO:0002190

BP

cap-independent translational initiation

The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.

RBM4

GO:0002192

BP

IRES-dependent translational initiation

The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.

DENR, EIF4EBP1, RBM4

GO:0002194

BP

hepatocyte cell migration

The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes.

PROX1

GO:0002215

BP

defense response to nematode

A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

PRG2, TNFSF4

GO:0002218

BP

activation of innate immune response

Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.

HMGB1, IFI16, MAVS, PYCARD

GO:0002221

BP

pattern recognition receptor signaling pathway

Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.

PGLYRP2, CLEC7A, DMBT1

GO:0002223

BP

stimulatory C-type lectin receptor signaling pathway

Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.

PSMD11, PSMD12, PSMD3, MAP3K7, RPS6KA5, PSMD10, PAK3, BCL10, NRAS, KRAS, RAF1, FYN, LYN, UBC, PLCG2, PRKACA, PSMC3, NFKB1, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, PSMC2, PSMB10, SYK, PSMC4, PSMB3, PSMD7, PSME3, PSMC1, PSMC6, RPS27A, UBA52, SKP1, RELB, RELA, PRKCD, EP300, PAK2, PSMD2, UBE2V1, PSME4, TAB1, TAB3, CLEC4D, CREBBP, CLEC7A, CD209, BTRC

GO:0002224

BP

toll-like receptor signaling pathway

Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

TLR4, TLR3, IRAK2, BCL10, CTSL, CTSB, HSP90B1, CTSS, CTSK, MAPKAPK2, IRAK1, TLR1, CNPY3

GO:0002227

BP

innate immune response in mucosa

Any process of the innate immune response that takes place in the mucosal tissues.

HIST1H2BK, HIST1H2BC, HIST2H2BE, BPIFB1