GO:0001701

BP

in utero embryonic development

The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.

ADAM10, MAFG, KDM6A, BCL2L11, KDM1A, EIF4E2, ZFAND5, SEC24D, CCNB2, MBD3, APOB, EDN1, ITGB1, GPI, TPM1, GLI2, GLI3, AR, FGFR1, BMP2, C6, CCNB1, FOSL1, VEGFA, GJA1, ERCC2, BTF3, FGFR2, EDNRA, NOS3, CTNNB1, MYH9, TIE1, SOX6, BMPR1A, ACVR1B, TGFBR1, HSD17B2, TGFBR2, MSH2, NOTCH1, UBE2A, DUSP3, SOX8, NLRP5, UBE2B, YBX1, SMAD3, PKD1, OCRL, APBA1, HHEX, GNA12, ACVR1, GABPA, SRSF1, FOXC1, MYO1E, SMAD4, CUL4A, PTCH1, ALKBH1, RCN1, ANGPT1, STIL, TWIST1, TAB1, SMAD2, AMOT, RNASEH2B, ANKRD11, UBR3, RBBP6, MIB1, RDH10, FLCN, ZFPM2, GATA6, ALS2, PITX2, RARRES2, PYGO2, CCM2, INPP5K, FUT8, ZNF335, TANC2, CHD8, MBNL1, RRN3, CHD7, KIDINS220, HEG1, ZMIZ1, MAFF, B9D1, MAPK8IP3, RTCB, KLF2, SLC30A1

GO:0001702

BP

gastrulation with mouth forming second

A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.

PLPP3, UGDH, LRP5, ACVR2A, CTNNB1, ACVR1, ZBTB17, SMAD4, ACVR2B, AMOT, TENM4, FRS2

GO:0001704

BP

formation of primary germ layer

The formation of the ectoderm, mesoderm and endoderm during gastrulation.

ATOH8

GO:0001706

BP

endoderm formation

The formation of the endoderm during gastrulation.

DKK1, DUSP1, DUSP2, SMAD2, DUSP5, SOX17

GO:0001707

BP

mesoderm formation

The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.

DKK1, GPI, PRKAR1A, PRKACA, NF2, BMPR1A, WNT3, SMAD3, ACVR1, BMPR2, SMAD2, TXNRD1, WLS, NR4A3, EXT2

GO:0001708

BP

cell fate specification

The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.

TBX1, ITGB1, APC, CTNNB1, NOTCH1, SOX9, PSEN1, PPDPF

GO:0001709

BP

cell fate determination

A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.

HOXA2, JAG1, NOTCH2, MCL1, PTCH1, PROX1, EBF2, CYP26B1

GO:0001710

BP

mesodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the mesoderm.

SMAD1

GO:0001711

BP

endodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the endoderm.

CTNNB1, RTF1

GO:0001712

BP

ectodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the ectoderm.

ETS2, ELF5

GO:0001714

BP

endodermal cell fate specification

The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.

POU5F1

GO:0001731

BP

formation of translation preinitiation complex

The joining of the small ribosomal subunit, ternary complex, and mRNA.

DENR, EIF3J, EIF4B, EIF2S3, EIF5, EIF3B, EIF3A, EIF3K

GO:0001732

BP

formation of cytoplasmic translation initiation complex

Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.

CDC123, EIF3A

GO:0001736

BP

establishment of planar polarity

Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.

FZD6, WNT5A, PTK7

GO:0001738

BP

morphogenesis of a polarized epithelium

The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.

AHI1

GO:0001743

BP

optic placode formation

The initial developmental process that will lead to the formation of an eye.

AXIN1

GO:0001754

BP

eye photoreceptor cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.

STAT3, AGTPBP1

GO:0001755

BP

neural crest cell migration

The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.

SEMA3E, TBX1, SEMA7A, SEMA3D, FGF19, KITLG, HTR2B, SOX8, ACVR1, SEMA3B, SEMA5A, SEMA3A, ERBB4, HIF1A, PHACTR4, SEMA6D, SEMA3C, SEMA6A, SEMA4A, SEMA6B, CORO1C

GO:0001756

BP

somitogenesis

The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.

PLXNA2, BMPR1A, WNT5A, PSEN1, PRKDC, SMAD3, EP300, TCF15, FOXC1, MIB1, ABI1, SEMA3C

GO:0001757

BP

somite specification

The process in which individual somites establish identity during embryogenesis.

COBL, MEOX1

GO:0001759

BP

organ induction

The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.

SPRY1, FGFR1, FRS2

GO:0001763

BP

morphogenesis of a branching structure

The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.

TCF21, TDGF1, COL13A1

GO:0001764

BP

neuron migration

The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.

MATN2, CHL1, NRP1, DCLK1, FYN, CCK, HSP90AA1, FBXO45, MAPT, FGFR1, GJA1, NR2F2, ITGA3, CTNNB1, NR4A2, NKX2-1, CXCL12, PSEN1, ASCL1, YWHAE, CDK5, PTK2, MEF2C, BAX, ALKBH1, GAS6, SEMA3A, PCM1, TWIST1, NTRK2, SDCCAG8, ASPM, POMGNT2, NAV1, DNER, NDNF, NRCAM, APBB2, FGF13, PITX2, TUBB2B, UNK, NDEL1, ELP3, ADGRL3, DDIT4, NDE1, CELSR3, MARK1, DCDC2

GO:0001765

BP

membrane raft assembly

The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.

FLOT1, ANXA2, EMP2, S100A10, RFTN1

GO:0001766

BP

membrane raft polarization

The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes.

MAL, DOCK2

GO:0001768

BP

establishment of T cell polarity

The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.

MYH9, DOCK2, CYP26B1

GO:0001771

BP

immunological synapse formation

The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.

CD6, EPHB1, DLG1, DOCK8, DOCK2

GO:0001773

BP

myeloid dendritic cell activation

The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

HMGB1, CD244, PYCARD

GO:0001774

BP

microglial cell activation

The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

TLR2, JUN, CLU, SNCA, TRPV1

GO:0001775

BP

cell activation

A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

TIMP1, CST3, PDGFA, IGF1, CCL3, PDGFRA, CD24, LYPD1

GO:0001777

BP

T cell homeostatic proliferation

The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.

BAX

GO:0001778

BP

plasma membrane repair

The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.

SYT11, MYH2

GO:0001779

BP

natural killer cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.

PIK3CD, TUSC2, STAT5B, ID2, SP3, TYRO3, MERTK

GO:0001780

BP

neutrophil homeostasis

The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.

ANXA1, MTHFD1, JAM3

GO:0001781

BP

neutrophil apoptotic process

Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

IL6

GO:0001782

BP

B cell homeostasis

The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.

BCL2L11, LYN, BCL2, MEF2C, BAX, SOS1, PKN1, FOXP3, RC3H2, TNFSF13B

GO:0001783

BP

B cell apoptotic process

Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.

BCL2L11, TRAF3IP2, TNFRSF21, BCL10, BAX, PKN1

GO:0001798

BP

positive regulation of type IIa hypersensitivity

Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.

C3

GO:0001809

BP

positive regulation of type IV hypersensitivity

Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response.

ZP3

GO:0001816

BP

cytokine production

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

PIK3CD, MAF, NFAT5, CD4, S100A8, S100A9, FABP4, PTAFR, LIPA, PIK3CG, NFATC2, NFATC2IP, S1PR3, FOXP3

GO:0001817

BP

regulation of cytokine production

Any process that modulates the frequency, rate, or extent of production of a cytokine.

LYN, CSK, IQGAP1, CD83, LITAF, F11R

GO:0001818

BP

negative regulation of cytokine production

Any process that stops, prevents, or reduces the rate of production of a cytokine.

RPS6KA5, SLC11A1, NDRG2

GO:0001819

BP

positive regulation of cytokine production

Any process that activates or increases the frequency, rate or extent of production of a cytokine.

EREG, FLOT1, AGT, TNF, HTR2B, SLC11A1, TMF1, IFI16, PELI1, HILPDA

GO:0001821

BP

histamine secretion

The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems.

ADA, EDN1

GO:0001822

BP

kidney development

The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.

BCL2L11, TCF21, ALDH1A2, CA2, ASS1, AGT, DCN, MME, GLI2, ODC1, BMP4, ACE, VEGFA, WT1, BMP6, MPST, AGTR1, TGFBR1, SERPINF1, CENPF, TMED10, CDKN1C, HRSP12, TGFB2, PKD1, PPAT, PAX8, BAX, HYAL2, ACVR2B, ARID5B, RGN, TNS2, JMJD6, NPHP3, SULF2, SULF1, PCSK9, PROX1, HAS2, PCSK5, PYGO2, ADAMTS1

GO:0001823

BP

mesonephros development

The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.

BMP4, ZBTB16, PAX8, OSR1

GO:0001824

BP

blastocyst development

The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.

PSMC3, TGFBR1, PSMC4, NASP, NEK2, DAD1, ELF3, POU5F1, MED21

GO:0001825

BP

blastocyst formation

The initial formation of a blastocyst from a solid ball of cells known as a morula.

MFN2, SKIL, ZP3, TJP1, RRP7A, SF3B6

GO:0001827

BP

inner cell mass cell fate commitment

The cell fate commitment of precursor cells that will become inner cell mass cells.

LATS1, LATS2

GO:0001828

BP

inner cell mass cellular morphogenesis

The morphogenesis of cells in the inner cell mass.

LATS1, SOX17, LATS2

GO:0001829

BP

trophectodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.

CNOT3, ADA, JUNB, SP3, HOPX

GO:0001831

BP

trophectodermal cellular morphogenesis

The morphogenesis of trophectoderm cells.

CUL3

GO:0001832

BP

blastocyst growth

An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.

NBN, RTF1

GO:0001833

BP

inner cell mass cell proliferation

The proliferation of cells in the inner cell mass.

ZPR1, BRCA2, GINS1, NCAPG2, GINS4, NDEL1, PRPF19, SBDS

GO:0001834

BP

trophectodermal cell proliferation

The proliferation of cells in the trophectoderm.

ZPR1

GO:0001836

BP

release of cytochrome c from mitochondria

The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.

SOD2, JUN, CCK, BCL2, CLU, SFN, BID, BAX, PMAIP1, TIMM50, BAD, MFF, BOK

GO:0001837

BP

epithelial to mesenchymal transition

A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

SNAI2, TGFB1, BMP2, HGF, FGFR2, S100A4, CTNNB1, TGFBR1, WNT5A, NOTCH1, SOX9, GSK3B, HMGA2, TGFB2, TGFBR3, TRIM28, CUL7, HIF1A, FAM101B, HNRNPAB, FAM83D, LOXL2

GO:0001840

BP

neural plate development

The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.

CTNNB1

GO:0001841

BP

neural tube formation

The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.

SOX4, STK4, MIB1

GO:0001843

BP

neural tube closure

The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.

ARID1A, PLXNB2, KDM6A, SPINT2, FZD6, COBL, TULP3, LRP6, BCL10, TGFB1, PFN1, RALA, MTHFD1, BMP4, SKI, PRKACA, SDC4, ADM, TSC2, LHX2, TGFB2, LMO4, RPS7, PTCH1, TMED2, STIL, TEAD2, TWIST1, MTHFD1L, PHACTR4, SHROOM3, GLMN, MED12, PRICKLE1, KIF20B, DLC1, IFT122, MKS1, CC2D2A, SUFU

GO:0001844

BP

protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway.

BCL2L11, BAX, PMAIP1, BAD, MOAP1

GO:0001845

BP

phagolysosome assembly

The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.

CORO1A

GO:0001867

BP

complement activation, lectin pathway

Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

MASP2, KRT1, MBL2, FCN2

GO:0001869

BP

negative regulation of complement activation, lectin pathway

Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway.

A2M, SERPING1

GO:0001878

BP

response to yeast

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.

ANG, APP, MPO, IL6, PTX3

GO:0001880

BP

Mullerian duct regression

The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos.

AMH, BMPR1A, AMHR2, SMAD5

GO:0001881

BP

receptor recycling

The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.

RAB11B, ALS2, EHD3, ARFGEF2

GO:0001885

BP

endothelial cell development

The progression of an endothelial cell over time, from its formation to the mature structure.

GPX1, VEZF1, CCM2

GO:0001886

BP

endothelial cell morphogenesis

The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.

MET, COL18A1, ID1, STC1, ARHGEF26, HEG1

GO:0001887

BP

selenium compound metabolic process

The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.

SEPP1, TXNRD1, SCLY

GO:0001889

BP

liver development

The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.

COBL, ALDH1A2, ADA, ASS1, KRAS, JUN, ASNS, QDPR, IGF2R, HGF, XBP1, SRD5A1, MPST, AK4, CAD, HMGCL, PIK3CA, NOTCH1, CEBPG, GFER, SMAD3, PKD1, HMGCS1, SP3, TGFBR3, RELA, PKD2, HNRNPD, HES1, ARID5B, AACS, LSR, PCSK9, RB1CC1, PROX1, GATA6, CITED2, CADM1, UPF2, SEC63

GO:0001890

BP

placenta development

The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.

E2F8, ADA, ANG, DCN, HSP90AB1, HSD17B2, PPARG, CCNF, LEP, RPS6, NDP, MC2R, PTK2, ALKBH1, CUL7, MAPK14, PHLDA2, HTRA1, CITED1, RTCB, MAP3K4

GO:0001892

BP

embryonic placenta development

The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.

EGFR, PDGFB, CEBPB, TFEB, ARNT, PKD1, HSF1, SP3, PKD2, HIF1A, EPAS1

GO:0001893

BP

maternal placenta development

Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.

NR2F2, AKT1, BMPR2, TMED2, DAZAP1

GO:0001894

BP

tissue homeostasis

A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.

RB1, AKR1B1, CTGF, SOX9, GNAS, STK11, GNAS, ANKRD11, TP53INP2, NANOS1, P2RX4, BARD1

GO:0001895

BP

retina homeostasis

A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.

ALB, TF, KRT1, HSPB1, AZGP1, ACTB, LYZ, B2M, ACTG1, PRDX1, POTEE, BBS1, WDR36, BBS10, POC1B, PROL1

GO:0001909

BP

leukocyte mediated cytotoxicity

The directed killing of a target cell by a leukocyte.

STXBP2

GO:0001910

BP

regulation of leukocyte mediated cytotoxicity

Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.

ICAM1

GO:0001912

BP

positive regulation of leukocyte mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.

CCL2

GO:0001913

BP

T cell mediated cytotoxicity

The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.

CTSH, CTSC, EMP2, MICB, MICA

GO:0001915

BP

negative regulation of T cell mediated cytotoxicity

Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.

PTPRC, IL7R, LILRB1

GO:0001916

BP

positive regulation of T cell mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.

STX7, HLA-E, IL12A, IL12RB1, B2M, FADD

GO:0001919

BP

regulation of receptor recycling

Any process that modulates the frequency, rate, or extent of receptor recycling.

LAMTOR1, TBC1D16

GO:0001920

BP

negative regulation of receptor recycling

Any process that stops, prevents, or reduces the rate of receptor recycling.

PCSK9, OPTN

GO:0001921

BP

positive regulation of receptor recycling

Any process that activates or increases the frequency, rate or extent of receptor recycling.

RAB29, RAMP3, SNCA, EPS15, NSG1, ECE1, NSF, PSEN1, VAMP3, BVES, ARAP1

GO:0001922

BP

B-1 B cell homeostasis

The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.

TNFAIP3, HIF1A

GO:0001927

BP

exocyst assembly

The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex.

EXOC2

GO:0001928

BP

regulation of exocyst assembly

Any process that modulates the frequency, rate or extent of exocyst assembly.

RALB

GO:0001932

BP

regulation of protein phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

PLXNB2, SOCS1, NDUFS4, TADA3, APOA1, FN1, LYN, STAT2, SESN2, PTK2, RAD51, CCDC88A, FLCN, FNIP1, PHIP, CELSR3, FNIP2, CORO1C

GO:0001933

BP

negative regulation of protein phosphorylation

Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.

PLPP3, CTDSP2, CTDSPL, PARK2, LRP6, SLIT2, TGFB1, PRNP, LYN, CCNB1, IGFBP3, FBLN1, SNCA, XDH, PTEN, PRKDC, INSM1, TARDBP, ANGPT1, PID1, DNAJC10, MICAL1, ZBED3, MYADM, CHP1, CIB1, INPP5K, FAM129A, CTDSP1, PARD6A, IMPACT, PPARGC1A, RABGEF1, CORO1C

GO:0001934

BP

positive regulation of protein phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

CYR61, CDK2AP1, MUSK, AXIN1, HDAC3, TBX1, ROCK2, FLOT1, FGF19, EGFR, F2, C3, KRAS, TGFB1, IGF2, TNF, IL1B, ERBB2, NTRK1, ITGB3, INSR, CSF1R, ANXA2, RAP2A, RALB, BMP2, BMP4, MMP9, VEGFA, MT3, ACVR2A, MAPK3, ERP29, CCND2, CCND3, AKT1, AKT2, FLT4, OPRL1, SOX9, CSNK1D, EFNA5, RAC1, RACK1, ADAM17, DAB2, TEK, PLAUR, PTK2, STK4, SQSTM1, RIPK1, GAS6, ERBB4, ADIPOQ, NTRK2, BRAT1, IL34, KNDC1, MAVS, FLCN, FBXO18, RB1CC1, FNIP1, ITLN1, MYDGF, GPER1, CIB1, RARRES2, PINK1, FAM129A, AKTIP, PELI2, TNIK

GO:0001935

BP

endothelial cell proliferation

The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.

ERN1, APOA1, HMOX1, XBP1, PIK3CB, MMP14, PRKX, TEK, DLG1, BMPR2, SCARB1, NOX5, THAP1, LOXL2

GO:0001936

BP

regulation of endothelial cell proliferation

Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.

ALDH1A2, LEP

GO:0001937

BP

negative regulation of endothelial cell proliferation

Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.

KRIT1, APOE, APOH, THBS1, SPARC, SCG2, GJA1, NR2F2, PTPRM, TGFBR1, XDH, CAV2, SYNJ2BP, CAV1, SULF1, ATOH8, RGCC, GHRL

GO:0001938

BP

positive regulation of endothelial cell proliferation

Any process that activates or increases the rate or extent of endothelial cell proliferation.

NRP1, NRP2, PDCD6, PDGFB, LRG1, ANG, ITGB3, JUN, FGF2, WNT2, BMP2, BMP4, CCL2, SCG2, VEGFA, PRKCA, BMP6, NR4A1, HMGB2, ARNT, AKT1, THBS4, FLT4, TGFBR1, WNT5A, HTR2B, STAT5A, CXCL12, PGF, VEGFC, CAV2, CDH13, TEK, EGR3, SEMA5A, BMPR2, PRKD1, HIF1A, RICTOR, VASH2, AGGF1, PROX1, MYDGF, PRKD2, PDCL3, ZNF580

GO:0001941

BP

postsynaptic membrane organization

A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).

CHRNB1

GO:0001942

BP

hair follicle development

The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.

LDB2, FZD6, LGR5, DKK1, EGFR, PDGFA, INHBA, ACVR1B, SOX9, LHX2, TGFB2, RELA, SOS1, NSDHL, APCDD1, LGR4, TNFRSF19

GO:0001944

BP

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.

TCF21, ZFAND5, FLT4, PIK3CA, STK11, ANP32B, B9D1

GO:0001945

BP

lymph vessel development

The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.

TBX1, FLT4, SYK, EFNB2, FOXC1, HEG1

GO:0001946

BP

lymphangiogenesis

Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.

FLT4, ACVR2B, BMPR2, CCBE1, PDPN, PROX1