GO:2001033

BP

negative regulation of double-strand break repair via nonhomologous end joining

Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via nonhomologous end joining.

HMGA2

GO:2001034

BP

positive regulation of double-strand break repair via nonhomologous end joining

Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.

RIF1

GO:2001037

BP

positive regulation of tongue muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation.

TBX1, CYP26B1

GO:2001038

BP

regulation of cellular response to drug

Any process that modulates the frequency, rate or extent of cellular response to drug.

HMGA2, NCOA1

GO:2001044

BP

regulation of integrin-mediated signaling pathway

Any process that modulates the frequency, rate or extent of integrin-mediated signaling pathway.

ITGB1BP1, TIMP1, PRKD1

GO:2001045

BP

negative regulation of integrin-mediated signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway.

CTNNA1, PHACTR4

GO:2001046

BP

positive regulation of integrin-mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway.

FLNA, EMP2

GO:2001054

BP

negative regulation of mesenchymal cell apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process.

TBX1, GDF5, SOX9, HIF1A

GO:2001056

BP

positive regulation of cysteine-type endopeptidase activity

Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity.

PYCARD

GO:2001076

BP

positive regulation of metanephric ureteric bud development

Any process that activates or increases the frequency, rate or extent of metanephric ureteric bud development.

WT1

GO:2001106

BP

regulation of Rho guanyl-nucleotide exchange factor activity

Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.

CCPG1

GO:2001108

BP

positive regulation of Rho guanyl-nucleotide exchange factor activity

Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.

EPHA4

GO:2001113

BP

negative regulation of cellular response to hepatocyte growth factor stimulus

Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus.

ADAMTS12

GO:2001135

BP

regulation of endocytic recycling

Any process that modulates the frequency, rate or extent of endocytic recycling.

RAB11B, BVES, NDRG4

GO:2001137

BP

positive regulation of endocytic recycling

Any process that activates or increases the frequency, rate or extent of endocytic recycling.

ACTN2, SORL1

GO:2001140

BP

positive regulation of phospholipid transport

Any process that activates or increases the frequency, rate or extent of phospholipid transport.

TRIAP1, PRELID1

GO:2001141

BP

regulation of RNA biosynthetic process

Any process that modulates the frequency, rate or extent of RNA biosynthetic process.

MITF, NCOA3

GO:2001150

BP

positive regulation of dipeptide transmembrane transport

Any process that activates or increases the frequency, rate or extent of dipeptide transmembrane transport.

CA2

GO:2001153

BP

positive regulation of renal water transport

Any process that activates or increases the frequency, rate or extent of renal water transport.

INPP5K

GO:2001170

BP

negative regulation of ATP biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process.

PID1, FLCN

GO:2001171

BP

positive regulation of ATP biosynthetic process

Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.

STAT3, VCP, PID1, PINK1, PPARGC1A

GO:2001180

BP

negative regulation of interleukin-10 secretion

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-10 secretion.

TNFRSF21, LILRB1

GO:2001181

BP

positive regulation of interleukin-10 secretion

Any process that activates or increases the frequency, rate or extent of interleukin-10 secretion.

PYCARD

GO:2001182

BP

regulation of interleukin-12 secretion

Any process that modulates the frequency, rate or extent of interleukin-12 secretion.

FOXP1

GO:2001183

BP

negative regulation of interleukin-12 secretion

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-12 secretion.

LILRB1

GO:2001184

BP

positive regulation of interleukin-12 secretion

Any process that activates or increases the frequency, rate or extent of interleukin-12 secretion.

MAPK14

GO:2001186

BP

negative regulation of CD8-positive, alpha-beta T cell activation

Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.

HFE, LILRB1

GO:2001189

BP

negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell.

LGALS3, LILRB1

GO:2001190

BP

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Any process that activates or increases the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell.

HLA-DMB

GO:2001193

BP

positive regulation of gamma-delta T cell activation involved in immune response

Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response.

LILRB1

GO:2001199

BP

negative regulation of dendritic cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.

HLA-G, TMEM176B, LILRB1, TMEM176A

GO:2001200

BP

positive regulation of dendritic cell differentiation

Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation.

HMGB1

GO:2001202

BP

negative regulation of transforming growth factor-beta secretion

Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor-beta secretion.

FN1, LILRB1

GO:2001204

BP

regulation of osteoclast development

Any process that modulates the frequency, rate or extent of osteoclast development.

TYROBP

GO:2001205

BP

negative regulation of osteoclast development

Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.

FBN1, LILRB1

GO:2001206

BP

positive regulation of osteoclast development

Any process that activates or increases the frequency, rate or extent of osteoclast development.

TNFSF11

GO:2001212

BP

regulation of vasculogenesis

Any process that modulates the frequency, rate or extent of vasculogenesis.

EMP2, HEY1

GO:2001213

BP

negative regulation of vasculogenesis

Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis.

XDH

GO:2001214

BP

positive regulation of vasculogenesis

Any process that activates or increases the frequency, rate or extent of vasculogenesis.

ADM, RAP1A

GO:2001222

BP

regulation of neuron migration

Any process that modulates the frequency, rate or extent of neuron migration.

PLXNB2, FLRT2, ULK4, ZSWIM6

GO:2001223

BP

negative regulation of neuron migration

Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.

GNRH1, COL3A1, STAT3, NRG1, ERBB4, ADGRG1

GO:2001224

BP

positive regulation of neuron migration

Any process that activates or increases the frequency, rate or extent of neuron migration.

SEMA3A, NSMF, KIF20B, SEMA6A

GO:2001225

BP

regulation of chloride transport

Any process that modulates the frequency, rate or extent of chloride transport.

CA2

GO:2001229

BP

negative regulation of response to gamma radiation

Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation.

PRKDC

GO:2001234

BP

negative regulation of apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.

BCL2, CTH, CTNNB1, NR4A2, PSEN1, IGBP1, BAX, MNT, MEIS3

GO:2001235

BP

positive regulation of apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.

INHBB, CTSH, TGFBR1, MAPK9, CTSC, CRADD, PRKCD, NFATC4, TPD52L1, TP53INP1, TRIM39

GO:2001236

BP

regulation of extrinsic apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway.

TRAF1, DEPTOR

GO:2001237

BP

negative regulation of extrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.

NRP1, CFLAR, SIAH2, NOL3, LMNA, IGF1, ITGAV, THBS1, GSTP1, AR, BMP4, SCG2, LGALS3, ITGA6, TGFBR1, HTT, YAP1, GCLC, GCLM, PSME3, RELA, ACVR1, RIPK1, CTTN, ZMYND11, RB1CC1, PHIP, TCF7L2, PAK7

GO:2001238

BP

positive regulation of extrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.

BCL10, AGT, G0S2, PDIA3, LTBR, AGTR2, TNFSF10, BID, CAV1, HYAL2, FADD, PAK2, RIPK1, GPER1, TNFRSF12A, CYLD, PYCARD

GO:2001239

BP

regulation of extrinsic apoptotic signaling pathway in absence of ligand

Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.

FGFR1

GO:2001240

BP

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.

EYA2, SNAI2, EYA4, TNF, IL1A, IL1B, PF4, FYN, HSPA1A, HSPA1B, BCL2, AKT1, CTNNA1, MCL1, MAP2K5, MAPK7, RIPK1, UNC5B, STRADB

GO:2001241

BP

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.

DAPK3, INHBA, FAS, PPP2R1A, PPP2R1B, CTNNA1, TGFB2, PPP1CA, BAX

GO:2001242

BP

regulation of intrinsic apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.

CYLD, PYCARD

GO:2001243

BP

negative regulation of intrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.

DDX3X, URI1, GCG, BCL2, MMP9, PPIF, VDAC2, PLAUR, MCL1, BCL2L2, NDUFA13, MAPK8IP1, NOC2L, IVNS1ABP

GO:2001244

BP

positive regulation of intrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.

BCL2L11, PRKRA, TP53, S100A8, S100A9, BCL2, BCAP31, BID, RACK1, CAV1, BAX, PMAIP1, SIAH1, FLCN, BAD, BCLAF1

GO:2001250

BP

positive regulation of ammonia assimilation cycle

Any process that activates or increases the frequency, rate or extent of ammonia assimilation cycle.

NR1H4

GO:2001256

BP

regulation of store-operated calcium entry

Any process that modulates the frequency, rate or extent of store-operated calcium entry.

STC2, SPINK1, HOMER1

GO:2001257

BP

regulation of cation channel activity

Any process that modulates the frequency, rate or extent of cation channel activity.

HOMER1, KCNIP2

GO:2001258

BP

negative regulation of cation channel activity

Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity.

MMP9, FGF12

GO:2001259

BP

positive regulation of cation channel activity

Any process that activates or increases the frequency, rate or extent of cation channel activity.

CTSS, ACTN2, ANK2, ANK3, KCNJ11

GO:2001268

BP

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.

MMP9, PLAUR

GO:2001271

BP

negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis.

PAK2, RFFL

GO:2001273

BP

regulation of glucose import in response to insulin stimulus

Any process that modulates the frequency, rate or extent of glucose import in response to insulin stimulus.

NGFR, REPIN1

GO:2001274

BP

negative regulation of glucose import in response to insulin stimulus

Any process that stops, prevents or reduces the frequency, rate or extent of glucose import in response to insulin stimulus.

PID1

GO:2001275

BP

positive regulation of glucose import in response to insulin stimulus

Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus.

AGT, PIK3R1, AKT2, IRS1, RNASEL, PTPN11, C2CD5, NR1H4, RARRES2, OSBPL8

GO:2001287

BP

negative regulation of caveolin-mediated endocytosis

Any process that stops, prevents or reduces the frequency, rate or extent of caveolin-mediated endocytosis.

UNC119

GO:2001288

BP

positive regulation of caveolin-mediated endocytosis

Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis.

NEDD4L

GO:2001295

BP

malonyl-CoA biosynthetic process

The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A.

ACACB

GO:2001300

BP

lipoxin metabolic process

The chemical reactions and pathways involving a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid.

ALOX5, HPGD

GO:2001303

BP

lipoxin A4 biosynthetic process

The chemical reactions and pathways resulting in the formation of lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.

ALOX15

GO:2001311

BP

lysobisphosphatidic acid metabolic process

The chemical reactions and pathways involving a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group.

ACP6

GO:0000015

CC

phosphopyruvate hydratase complex

A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water.

ENO1, ENO2, ENO3

GO:0000109

CC

nucleotide-excision repair complex

Any complex formed of proteins that act in nucleotide-excision repair.

ERCC1, POLD1, ERCC4

GO:0000110

CC

nucleotide-excision repair factor 1 complex

One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively.

ERCC1, XPA, ERCC4

GO:0000111

CC

nucleotide-excision repair factor 2 complex

One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p.

XPC

GO:0000118

CC

histone deacetylase complex

A protein complex that possesses histone deacetylase activity.

SAP18, HDAC3, TBL1X, ZNF217, NCOR1, TAL1, CBX5, NRIP1, HINT1, HDAC4, HDAC1, HDAC7, HDAC8, TBL1XR1, DNTTIP1, RERE, HDAC6, HDAC9, HDAC5, NCOR2

GO:0000120

CC

RNA polymerase I transcription factor complex

A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I.

CD3EAP, TAF1C, TAF1A

GO:0000123

CC

histone acetyltransferase complex

A protein complex that possesses histone acetyltransferase activity.

OGT, IKBKAP, EP300, JADE1, JADE3, CREBBP, ELP4, PHF20, ELP3, KANSL3

GO:0000124

CC

SAGA complex

A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.

USP27X, SUPT3H, TADA3, USP34, USP51, TAF9B, ENY2, USP22

GO:0000125

CC

PCAF complex

A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.

TADA2A, TAF10, KAT2B, TRRAP

GO:0000127

CC

transcription factor TFIIIC complex

A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.

GTF3C2, GTF3C4

GO:0000137

CC

Golgi cis cisterna

The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.

GOLGA2, NECAB3, TMEM59

GO:0000138

CC

Golgi trans cisterna

The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.

B4GALT1, SGMS1, HID1, TMEM59

GO:0000139

CC

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

GPR89A, SLC33A1, GOLIM4, EBAG9, PPP6C, COPE, AP3D1, GOSR2, ANKRD28, LEPROT, SURF4, GRM6, TLR3, B4GALT5, B4GAT1, KDELR3, CYTH3, STX6, B3GALT2, HS6ST1, TPST1, B4GALT4, TPST2, FAM20B, ENTPD6, VAMP4, SEC22B, AP1G2, TRAPPC6A, SEC24D, SEC31A, CLSTN1, CSPG5, TNKS, VAPB, SNAPIN, LARGE, SNAP29, B3GALT4, F8, EGFR, SERPINA1, NRAS, PDGFB, TGFA, INS, HLA-B, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, PDGFA, CD74, CYP2E1, CD55, FURIN, GPR89B, TRAPPC2, SRGN, SLC2A1, F5, NCAM1, HLA-E, HLA-DRB4, B4GALT1, FOLR1, AREG, ST6GAL1, GJA1, HLA-G, ATF6, HLA-DPA1, OSBP, FUT4, KDELR1, NOS3, HLA-A, HLA-F, GBP1, GBP2, MAN1A1, BSG, TRIM23, SREBF1, IFNGR2, PRKCI, NSG1, NSF, NOTCH1, ARCN1, TRAPPC10, CSNK1D, PITPNB, MAN2A2, TMED10, PSEN1, PSEN2, CAV2, CLCN3, CLCN5, NDST1, ARFIP1, COPA, CTSC, EMP2, SEC13, AP1S2, GABARAPL2, CDC42, RAB2A, ST8SIA6, B2M, COPZ1, AP1S1, RAB1A, RAC1, SLC35A2, SLC35A1, HLA-DRB3, TMF1, ARF1, PKD1, ATP2C1, CAV1, NOTCH2, ICA1, GOLGA2, MGAT2, GALNT2, GALNT1, AP1B1, ST3GAL1, ST3GAL3, ST3GAL4, SREBF2, HYAL2, MALL, CLN3, PLD1, GOLGA4, SERINC3, CUL3, CUX1, COG2, TMED2, RHEB, DHCR24, SEC23A, TRIP11, EXT1, UGCG, ST3GAL2, TMEM132A, HLA-DRB5, GNPTAB, MGAT5B, KLHL12, WIPI1, MANEA, ARHGAP21, WLS, STEAP4, RAB12, RHBDD2, AGTRAP, PARM1, C6orf89, B3GNT9, CHSY3, SLC35D2, RHOU, LPCAT2, CHST15, HS2ST1, CHST3, GALNT5, GALNT7, GALNT10, SGMS1, CHSY1, GPSM1, ERC1, ZDHHC17, TRAPPC5, HACE1, KIAA0319L, DSEL, GCNT2, GALNT15, GALNT4, ARFGAP2, CHST4, B3GNT7, SVIP, MCFD2, TMEM167A, CSGALNACT1, PXYLP1, RAB2B, ABCA5, ST8SIA4, GBF1, TFG, GLG1, EXT2, PMEPA1, ERGIC1, RHBDF1, OPTN, GALNT14, PGAP3, SEC16B, ST6GAL2, HS6ST2, GPER1, MPHOSPH9, PKMYT1, CHP1, SH3GL2, SLC35A5, NDFIP1, PDCD10, APOO, ST6GALNAC5, TAPBPL, TMEM59, FUT8, B3GNT5, PDGFD, CHST5, CHST6, GBP3, RAB1B, LMAN2L, XYLT2, BLZF1, TNKS2, ACBD3, CLSTN2, ST6GALNAC4, GLIPR2, NAA60, RNF121, FKRP, GBA2, GOPC, ABCB6, ARFGAP3, PNPLA8, CHST11, MAN1C1, PDGFC, RAB6B, AGPAT3, CHST7, NDFIP2, SYBU, SMPD4, ZDHHC7, B3GNT2, BET1L, VAPA, PI4KB, CTSZ, B4GALT6, SCOC, ST6GALNAC2, GNPTG, DSE, TMCO1, MGAT4A, BOK, PPP6R1, MAPK8IP3, MGAT4B, RNF24, ST3GAL6, ITM2B, SLC35A3, PIKFYVE, COG6, SH3GLB1, GOLT1B, TMED3, CHST2, TRAPPC1, HS3ST3B1, COPG1, ARFGEF2

GO:0000145

CC

exocyst

A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.

WASH1, EXOC5, EXOC3, RALB, TNFAIP2, SEPT2, MYRIP, STXBP6, EXOC4, EXOC2, EXOC1, EXOC7

GO:0000151

CC

ubiquitin ligase complex

A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

ASB14, WWP2, GPR37, MED7, PARK2, FBXO24, RNF8, UBE4B, HSPA1A, HSPA1B, DNAJA1, BRCA1, BRCC3, RNF144A, UBE2E1, UBE2V1, MED21, RNF19B, UBR3, CBLL1, RNF144B, CAND1, UBR1, UBE2J2, FBXO25, DCUN1D4, DYRK2, MED12, MIB2, DCUN1D1, MED30, GMCL1, ASB16, MPHOSPH8, BARD1, PINK1, WWP1, MED20, SMURF2, FBXO8, RNF19A, MED17, RNF216, RNF14, FBXL7, FBXO10, FBXO9, STUB1, SUGT1, ARIH1, ASB3

GO:0000152

CC

nuclear ubiquitin ligase complex

A ubiquitin ligase complex found in the nucleus.

BRCC3

GO:0000159

CC

protein phosphatase type 2A complex

A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.

PPP2R1A, PPP2CB, CYCS, PPP2R3A, STRN3, PPP2R5C, PPP2R5D, PPP2R5A, PPP2R5B, PPP2R4, STRN4

GO:0000164

CC

protein phosphatase type 1 complex

A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.

PPP1R11, PPP1R15A, PPP1R2, PPP1CA, PPP1CB, PPP1R3B

GO:0000172

CC

ribonuclease MRP complex

A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.

POP4

GO:0000176

CC

nuclear exosome (RNase complex)

A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.

EXOSC9, EXOSC2, C1D, EXOSC7, EXOSC6, EXOSC8, EXOSC4, EXOSC3, DIS3

GO:0000177

CC

cytoplasmic exosome (RNase complex)

A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.

EXOSC9, EXOSC2, EXOSC7, EXOSC6, EXOSC8, EXOSC4, EXOSC3, DIS3, CARHSP1

GO:0000178

CC

exosome (RNase complex)

A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.

SKIV2L2, EXOSC9, EXOSC2, EXOSC7, EXOSC6, KHSRP, EXOSC8, EXOSC4, EXOSC3, DIS3

GO:0000220

CC

vacuolar proton-transporting V-type ATPase, V0 domain

The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.

TCIRG1, ATP6V0A1

GO:0000221

CC

vacuolar proton-transporting V-type ATPase, V1 domain

The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.

ATP6V1H

GO:0000228

CC

nuclear chromosome

A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.

BIRC5, H2AFY, SMC2, ZBED1, JUN, TOP1, TOP2A, MSH3, MSH6, HMGA2, BLM, HIST1H4A, HIST1H3D, H3F3A, EXOSC9, RAD51, SPIDR, NCAPD2, SETX, PBRM1, HDAC8

GO:0000235

CC

astral microtubule

Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.

MAP9, KIF18B

GO:0000242

CC

pericentriolar material

A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.

CEP152, TNKS, TCP1, TUBG1, PCM1, HOOK3, NIN, NEK1, TNKS2, TUBE1

GO:0000243

CC

commitment complex

A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript.

SNRPC, SNRPD1, SNRPD3, SNRNP35, PRPF39

GO:0000274

CC

mitochondrial proton-transporting ATP synthase, stator stalk

One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core.

ATP5H