GO:0000275

CC

mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)

The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled.

ATP5D, ATP5C1, ATP5E

GO:0000276

CC

mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins.

ATP5L, ATP5J, ATP5G3, ATP5I, ATP5G2

GO:0000307

CC

cyclin-dependent protein kinase holoenzyme complex

Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.

CDK4, CDK2, CCND2, CCND3, CKS2, CDKN1A, CKS1B, CDK6, CCNL2, CCNL1

GO:0000322

CC

storage vacuole

A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.

CDC42, STX4, ARHGEF7

GO:0000346

CC

transcription export complex

The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.

ZC3H11A, SARNP, THOC7, ALYREF, THOC2, THOC3, POLDIP3, NXF1

GO:0000347

CC

THO complex

The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.

THOC7, THOC2

GO:0000407

CC

pre-autophagosomal structure

A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes.

ATG13, SQSTM1, NBR1, WIPI1, ATG2B, VMP1, ZFYVE1, WIPI2

GO:0000408

CC

EKC/KEOPS complex

A protein complex involved in t6A tRNA modification; originally proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p.

TP53RK

GO:0000421

CC

autophagosome membrane

The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.

SNAP29, RAB7A, GABARAPL2, CALCOCO2, WIPI1, TECPR1, ATG16L2, VMP1, MAP1LC3B, GABARAPL1, MAP1LC3A, SH3GLB1

GO:0000439

CC

core TFIIH complex

The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD.

ERCC2, GTF2H1, GTF2H2, GTF2H2C_2, GTF2H4

GO:0000444

CC

MIS12/MIND type complex

A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1.

NSL1, DSN1

GO:0000445

CC

THO complex part of transcription export complex

The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.

THOC7, THOC2, THOC3

GO:0000446

CC

nucleoplasmic THO complex

The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits.

THOC7

GO:0000502

CC

proteasome complex

A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.

PSMD11, PSMD12, PSMD3, PSMD10, HSPB1, PSMC3, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, PSMC2, PSMB10, PSMC4, PSMB3, PSMD7, RAD23A, RAD23B, VCP, SHFM1, PSME3, PSMC1, PSMC6, PSMD2, UBE3C, ADRM1, UBR1, PAAF1, PSMG3

GO:0000506

CC

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast.

PIGA, PIGH, PIGY, PIGC

GO:0000775

CC

chromosome, centromeric region

The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

NDC80, BIRC5, OIP5, RAD21, TNKS, CENPB, PPP2R1A, MKI67, CENPA, CENPF, PPP2CB, CBX1, CENPE, FMR1, CBX3, PPP2R5C, SMC1A, PPP2R5A, PDS5A, CDCA8, SGOL2, CENPW, SGOL1, CENPQ, WAPL, CENPL, HJURP, NGDN, CDCA5, KIF2C, DSCC1, NUF2, SUV39H2, HELLS, PDS5B, MIS18A, SMC3, ZNF330

GO:0000776

CC

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

DYNC1I1, NDC80, PPP1R12A, XPO1, ZNF207, BUB1, BUB3, BUB1B, ZWINT, TPR, APC, CLIP1, CBX5, RANGAP1, CENPF, PSEN1, PSEN2, NEK2, PLK1, SEC13, SUMO3, NUP107, DYNLL1, CENPE, CENPC, NUP160, MAD2L1, DCTN2, CKAP5, DCTN1, SMC1A, KIF22, CENPW, SGOL1, CENPV, TEX14, SKA3, ZNF276, NUP43, NUP37, KIF18A, KAT2B, ANAPC16, SEH1L, AURKB, SPAG5, KIF2C, NUP85, NDEL1, CENPH, ZWILCH, MEAF6, NDE1, LRWD1, SUGT1, KNSTRN, MAD1L1

GO:0000777

CC

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

STRA13, DCTN6, DYNC1I1, NDC80, BIRC5, ZNF207, BUB1, BUB3, BUB1B, ZWINT, PPP1CC, RANGAP1, CSNK1A1, KNTC1, NEK2, NUP107, CENPC, MAD2L1, ITGB3BP, SEPT6, SMC1A, SEPT2, SEPT7, ERCC6L, SGOL2, CENPW, SGOL1, CENPU, CENPV, TEX14, APITD1, ZNF276, SPC24, HJURP, NUP43, NUP37, CASC5, NUDCD2, AHCTF1, ANAPC16, SEH1L, CENPN, BOD1, CHAMP1, SPAG5, KIF2C, CENPK, DCTN5, CENPO, NUP85, NUF2, NDEL1, CENPH, ZWILCH, MEAF6, SPC25, CENPM, NDE1, CFDP1, LRWD1, KNSTRN, MAD1L1

GO:0000778

CC

condensed nuclear chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed nuclear chromosome and provides an attachment point for the spindle microtubules.

BUB1B, CENPA, MIS18BP1

GO:0000779

CC

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

CEBPB, NCAPD3, CENPE, CBX3, NCAPD2, SGOL1, AURKB

GO:0000780

CC

condensed nuclear chromosome, centromeric region

The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

AURKA, CENPA, CENPC, KMT5B, SGOL1, KMT5C, AURKB

GO:0000781

CC

chromosome, telomeric region

The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.

CHEK1, RAD51D, RNF8, TNKS, H2AFX, CDK2, MRE11A, BLM, PTGES3, RIF1, SETX, SIRT2, SMC5, EID3, ERCC4, SMC6, TEP1, DHX36, POT1, NSMCE4A

GO:0000783

CC

nuclear telomere cap complex

A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome.

XRCC5, TERF1, ACD, POT1

GO:0000784

CC

nuclear chromosome, telomeric region

The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.

SMCHD1, ORC5, KDM1A, NBN, H2AFY, RAD51D, TOX4, TNKS, SSB, CDK1, ERCC1, PARP1, PCNA, XRCC5, SP100, MCM3, POLD1, POLR2B, HIST1H2BB, MCM4, MCM5, MCM7, PPP1CC, FEN1, MSH2, CBX5, ATRX, MCM2, MRE11A, DNA2, BRCA2, TERF1, PPP1CA, PPP1CB, HIST1H4A, HIST1H3D, PRKDC, CBX1, H3F3A, PURA, RAD51, CBX3, ORC1, MCM6, LRIF1, THOC7, ALYREF, THOC2, RAD50, ERCC4, NABP1, ACD, THOC3, PPP1R10, DCLRE1C, NABP2, TNKS2, PIF1, OBFC1, POT1, GAR1, H2AFY2, ORC3, SUN2

GO:0000785

CC

chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.

HMGN4, CHEK1, OIP5, RAD21, MAF, TOX4, MBD4, MYCN, HMGN2, RB1, POLA1, CDK4, JUNB, JUND, SFPQ, CCND2, MCM7, TMPO, TMPO, CENPF, UBE2A, MCM2, PLK1, UBE2B, CBX1, RAD51, CBX3, HDAC1, KIF22, JMJD1C, PDS5A, ESCO2, NIPBL, WAPL, SLF2, FBXO18, AHCTF1, PPP1R10, DSCC1, PINK1, NUCKS1, SUV39H2, PDS5B, PARPBP, MIS18A, PLK2, SMC3, L3MBTL1

GO:0000786

CC

nucleosome

A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.

H2AFY, H2AFZ, HIST1H2AG, HIST1H1E, H2AFX, HIST1H1C, HIST1H2AD, HIST1H2BB, CENPA, HIST1H4A, HIST1H2BC, HIST1H3D, H3F3A, HIST1H1A, SHPRH, HIST2H2BE, HIST2H2AA3, H2AFV, KAT6B, H1FX, KAT6A, HIST1H2AC, HIST1H2BH, SLF1, H2AFJ, H2AFY2

GO:0000788

CC

nuclear nucleosome

A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures.

HIST1H2BK, HIST1H2BB, CENPA, HIST1H2BD, HIST1H2BC, HIST1H3D, H3F3A, HIST2H2BE, HIST3H2A, HIST1H2BH, MPHOSPH8

GO:0000790

CC

nuclear chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

EME2, DFFA, ARID1A, ENC1, POLR3G, KLF4, SNAI2, KDM1A, H2AFY, NCOR1, NFATC1, CBX7, MBD3, ACTL6A, ESR1, TP53, HNRNPC, HIST1H2AG, AR, IRF1, TCF4, TCF3, MUC1, H2AFX, JUNB, JUND, TAL1, CEBPB, RCC1, NR1D1, HIST1H2AD, HMGB2, STAT3, BUD31, NRIP1, NASP, UBE2A, SMARCA2, SMARCA4, MSH6, HIRA, DLX5, ACTB, UBE2B, SMAD3, E2F1, MEF2A, HIST1H1A, PPARD, RELA, MXD1, GABPA, RAD51, RBBP4, CHAF1A, CHAF1B, NR1H3, SMAD4, HDAC1, RUNX3, RUNX2, CHD4, NCOA1, SMAD2, EZH2, HIST2H2AA3, SMARCD3, H2AFV, CCAR2, SMARCC2, IPO4, HDAC2, CREBBP, RAD50, SMARCC1, HIST1H2AC, WBP2, EME1, RAD51AP1, CDCA5, PAWR, EHMT2, UHRF1, TCF12, CITED2, POLR3GL, H2AFJ, TIPIN, NUCKS1, PLCB1, TCF7L2, ASF1B, H2AFY2, TRPS1, TIMELESS, ASF1A, NCOR2, NCOA3

GO:0000791

CC

euchromatin

A dispersed and relatively uncompacted form of chromatin.

HSF1, RRP1B, UHRF1

GO:0000792

CC

heterochromatin

A compact and highly condensed form of chromatin.

CBX7, MBD3, UBA1, HSF1, RRP1B, UHRF1, SMARCAD1

GO:0000793

CC

condensed chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

SMARCA5, H2AFY, BANF1, SMC2, HMGB1, TOP2A, CDK2, HMGB2, MKI67, RAD51, NCAPD2, CHAMP1, FANCD2, BAZ1B, L3MBTL1

GO:0000794

CC

condensed nuclear chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.

CHEK1, RGS12, RAD51C, BRD4, H2AFX, RCC1, TUBG1, LRPPRC, NEK2, RAD51, SMC1A, RRS1, RSPH1, TTN, TOPBP1, P3H4, KIFAP3, RAD50, NIFK, ADD3, SUN2

GO:0000795

CC

synaptonemal complex

A proteinaceous scaffold found between homologous chromosomes during meiosis.

SYN1, MLH1, PLK1, PMS1, UBE2I, WAPL, P3H4, MLH3

GO:0000796

CC

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

SMC2, NCAPH, NCAPD2, NCAPG, SMC4

GO:0000797

CC

condensin core heterodimer

The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation.

NCAPD2

GO:0000798

CC

nuclear cohesin complex

A cohesin complex required for cohesion between sister chromatids that remain in the nucleus.

WAPL

GO:0000799

CC

nuclear condensin complex

A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus.

NCAPD3, NCAPD2

GO:0000800

CC

lateral element

A proteinaceous core found between sister chromatids during meiotic prophase.

BRCA1, BRCA2, BLM, RAD51, SMC3

GO:0000803

CC

sex chromosome

A chromosome involved in sex determination.

SMC5, SMC6

GO:0000805

CC

X chromosome

The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.

SIN3B, CDK2

GO:0000806

CC

Y chromosome

The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males.

SIN3B, CDK2

GO:0000808

CC

origin recognition complex

A multisubunit complex that is located at the replication origins of a chromosome.

ORC5, ORC1, ORC3, ORC6

GO:0000811

CC

GINS complex

A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.

GINS1, GINS4, GINS2

GO:0000812

CC

Swr1 complex

A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.

ZNHIT1, ANP32E, ING3, RUVBL2, RUVBL1, TRRAP

GO:0000813

CC

ESCRT I complex

An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.

VPS37C, UBAP1L, VPS37A, MVB12A

GO:0000815

CC

ESCRT III complex

An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes.

CHMP2A, CHMP4B

GO:0000818

CC

nuclear MIS12/MIND complex

A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.

DSN1

GO:0000836

CC

Hrd1p ubiquitin ligase complex

A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78).

OS9, SYVN1, SEL1L

GO:0000838

CC

Hrd1p ubiquitin ligase ERAD-M complex

A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.

AMFR

GO:0000839

CC

Hrd1p ubiquitin ligase ERAD-L complex

A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.

SYVN1, SEL1L

GO:0000922

CC

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

DYNC1I1, WDR62, PRC1, CEP104, VPS4B, TNKS, LATS1, CCNB1, CDC25B, CTNNB1, NUP62, RANGAP1, BRCC3, CENPF, KNTC1, NEK2, KIF11, PLK1, CALM2, RAB11A, PPP2CB, GOLGA2, CDC20, LRMP, MAD2L1, UNC119, CKAP5, DCTN1, NEDD9, MAPK14, CSPP1, FAM110C, ODF2, SGOL1, FRY, PSRC1, CEP128, CKAP2L, NIN, POC1A, POC1B, NEK7, FBF1, NUDCD2, CKAP2, TOPBP1, HAUS1, RMDN1, SPDL1, CEP19, RMDN2, SPAG5, CEP89, PKP4, CDC6, KATNB1, CEP44, DSN1, AUNIP, NEK6, LATS2, RASSF1, TPX2, CDC14A, SMC3, SBDS, KNSTRN, MAD1L1

GO:0000923

CC

equatorial microtubule organizing center

A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis.

MZT1, TUBGCP3

GO:0000930

CC

gamma-tubulin complex

A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species.

TUBG1, CKAP5, UXT

GO:0000932

CC

cytoplasmic mRNA processing body

A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci.

MEX3A, ZC3H12D, CNOT1, POLR2D, CNOT3, EIF4E, TOP1, PSMC3, PSMA2, PSMA4, ZFP36, PSMC2, LSM3, LSM6, POLR2G, ZFP36L1, SQSTM1, CAPRIN1, PUM1, PAN3, SAMD4B, DCP2, LSM14A, TNRC6A, RBPMS, EDC3, AJUBA, LIN28A, RC3H2, APOBEC3G, AGO4, PNRC2, EIF4ENIF1, LIMD1, CNOT7, NOCT, AGO2, TNRC6B, SAMD4A, CARHSP1, LSM2, LSM4, YTHDF2

GO:0000938

CC

GARP complex

A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles.

VPS52

GO:0000939

CC

condensed chromosome inner kinetochore

The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.

CENPA

GO:0000940

CC

condensed chromosome outer kinetochore

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

BUB1B, CENPF, CENPE, SKA3, SKA2, SKA1, SPDL1

GO:0000941

CC

condensed nuclear chromosome inner kinetochore

The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.

DSN1

GO:0000942

CC

condensed nuclear chromosome outer kinetochore

The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

NDC80, BUB1, CCNB1, PLK1

GO:0000974

CC

Prp19 complex

A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.

PLRG1, POLR2A, CDC5L, CRNKL1, RBM22, PRPF19

GO:0001401

CC

mitochondrial sorting and assembly machinery complex

A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.

SAMM50

GO:0001405

CC

presequence translocase-associated import motor

Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix.

GRPEL1, PAM16

GO:0001518

CC

voltage-gated sodium channel complex

A sodium channel in a cell membrane whose opening is governed by the membrane potential.

SCN9A

GO:0001520

CC

outer dense fiber

A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins.

AK1, ODF2, RSPH1

GO:0001527

CC

microfibril

Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.

FBN1, FBN2, MFAP2, MFAP5, LTBP1, THSD4, ADAMTS10

GO:0001533

CC

cornified envelope

A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes).

CSTA, ANXA1, DSP, SPRR2B, KAZN, SPRR2G, SPRR3

GO:0001534

CC

radial spoke

Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.

RSPH4A, C6orf165

GO:0001650

CC

fibrillar center

A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.

UTP15, UTP4

GO:0001651

CC

dense fibrillar component

A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.

SNU13

GO:0001652

CC

granular component

A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.

CLEC3B, CDKN2AIP

GO:0001669

CC

acrosomal vesicle

A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.

SPAG9, CRCP, SPINK1, KIT, SKIL, DRD2, TCP1, NCF2, ZP3, CALR, CTNNA1, NUDT1, NOTCH1, CXADR, LOXL1, MORN2, SV2B, ARC, IQUB, CASC5, ENKUR, SLIRP, RACGAP1, VEZT, TSKS, POMT1

GO:0001673

CC

male germ cell nucleus

The nucleus of a male germ cell, a reproductive cell in males.

H2AFX, MLH1, TRIP13, TOPBP1, MLH3, TCFL5

GO:0001725

CC

stress fiber

A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

ABLIM1, ACTN4, FLNB, NEBL, ABLIM3, TPM3, TPM1, ACTN1, LCP1, MYL9, MYH9, TPM4, TEK, PTK2, ILK, MYLK, ZYX, SEPT7, FSCN1, FBLIM1, PDLIM2, CORO1B, SORBS1, NOX4, PDLIM7, LIMA1, DAAM1, FHOD1

GO:0001726

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ruffle

Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

ITGB1BP1, MTSS1, CYTH3, COBL, S100B, ITGB1, S100A6, ANXA2, ITGA5, ACTN1, LCP1, EZR, RAB5A, RASA1, ATP6V1B2, NME2, CLIP1, S100A11, RDX, MYH9, IQGAP1, CDK6, MTM1, ARHGEF7, CTTN, FSCN1, AMOT, FGD6, CYFIP1, FGD2, PDPN, KIF18A, ARAP3, PALLD, ARHGEF26, FGD4, ALS2, TRPM7, MYADM, INPP5K, MYO10, TNFRSF12A, PARD6A, PDLIM7, INPP5E, SAMSN1, RAB22A, MKLN1, MYO6, FRMD4B, TLN1, MYO5A, SNX9, SNX5, WASF2

GO:0001739

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sex chromatin

Chromatin that is part of a sex chromosome.

H2AFY, RING1, SUZ12

GO:0001740

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Barr body

A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.

SMCHD1, H2AFY, H3F3A, H2AFY2

GO:0001741

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XY body

A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.

PLK4, SIN3B, H2AFX, UBE2A, UBE2B, ESCO2, SMARCC1

GO:0001750

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photoreceptor outer segment

The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes.

OPN1SW, INHA, MAK, PDC, PTGS1, GNA11, MAP1B, GNAQ, RAB27A, OCRL, MERTK, PTPRK, BBS7, MYRIP, RPGR, MYO5A

GO:0001772

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immunological synapse

An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.

SOCS6, STX7, BCL10, ICAM1, PRKAR1A, CD28, EZR, LGALS3, CD53, CD6, CORO1A, MYH9, DUSP3, CD81, PRKCQ, PTPRJ, DLG1, ALCAM, PDCD6IP

GO:0001891

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phagocytic cup

An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.

MYO1G, PIP5K1C, TNF, ANXA1, LCP1, CORO1A, RAC1, RACK1, TRIP10, PEAR1, MEGF10, SYT11, CDC42SE2, BIN2, SNX5

GO:0001917

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photoreceptor inner segment

The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.

INHA, ENO2, MAK, PDC, GNB1, CROCC, DRAM2, PHLPP2, RDH11, GUCA1B

GO:0001931

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uropod

A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.

PIP5K1B, PIP5K1C, FLOT1, EZR, MYH9, SELPLG

GO:0001939

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female pronucleus

The pronucleus originating from the ovum that is being fertilized.

SLC2A1, CCNA2, CBX1, RIF1

GO:0001940

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male pronucleus

The pronucleus originating from the spermatozoa that was involved in fertilization.

CCNA2, CBX1, RIF1

GO:0002079

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inner acrosomal membrane

The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.

CD46, TRIP11

GO:0002080

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acrosomal membrane

The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.

SERPINA5, BSG, CAV2, CAV1, PLA1A

GO:0002081

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outer acrosomal membrane

The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.

ZP3, TRIP11

GO:0002102

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podosome

An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.

SH3PXD2B, LPXN, WDR1, LCP1, VCAM1, TPM4, ADAM8, ARHGEF5, CTTN, FSCN1, RHOU, PALLD, BIN2

GO:0002116

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semaphorin receptor complex

A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

NRP1, PLXNB2, NRP2, PLXNC1, PLXNA2, PLXNA3, PLXNA1, PLXND1

GO:0002133

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polycystin complex

A stable heterodimeric complex composed of polycystin-1 and polycystin-2.

PKD1, PKD2

GO:0002169

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3-methylcrotonyl-CoA carboxylase complex, mitochondrial

A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.

MCCC1, MCCC2

GO:0002177

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manchette

A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.

IQCG

GO:0002178

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palmitoyltransferase complex

A protein complex with palmitoyltransferase activity.

ZDHHC9

GO:0002189

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ribose phosphate diphosphokinase complex

A protein complex having ribose phosphate diphosphokinase activity.

PRPS1

GO:0002193

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MAML1-RBP-Jkappa- ICN1 complex

A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.

NOTCH1

GO:0002199

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zona pellucida receptor complex

A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.

TCP1, CCT3, CCT8, CCT2, CCT7

GO:0002944

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cyclin K-CDK12 complex

A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.

CDK12

GO:0002945

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cyclin K-CDK13 complex

A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.

CDK13

GO:0002947

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tumor necrosis factor receptor superfamily complex

A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily.

RFFL

GO:0005575

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cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

TMEM129, TMEM120B, SBNO1, NUDT19, TRIM38, DLGAP1, KHNYN, SOX12, DENR, TRAF3IP2, ZNF862, EIF1B, USP12, PDE5A, ZFAND5, PDE8B, GDF11, DHFR, SCT, ZNF688, PSKH1, ODC1, TPR, CCDC130, S100A2, NPTX2, SLC6A8, PLA2G16, SHC2, RNASEL, DMWD, MN1, TFCP2, TRIM26, NPRL3, SCGB2A2, MAMLD1, FAM53B, NOMO1, FAM189A2, QRICH1, LRRFIP1, ARID4B, LRRC23, TMEM35, ACSM3, ANKRD39, BOLA3, TMEM128, RALGPS1, MLK4, ANKRD45, SPTY2D1, ANKRD40, ZFAND6, ADNP2, TTC27, RNASEK, TMEM107, TMEM108, ADAMTSL4, TMEM91, LHFPL2, PTCHD4, USP53, SLC35D2, KNDC1, ENOSF1, KDELC2, GALNT5, THNSL2, CARKD, SLC35F2, THNSL1, GCNT2, TMEM132C, OXR1, ABTB2, SLC43A3, SMG8, PAPD5, ABHD11, WDR36, AGR3, DNAH5, SCFD2, CHAC2, SNRNP27, RIN2, SUSD6, KIAA1191, FLYWCH2, MOCOS, DTD2, PBK, ZFP3, PCYT2, CDCA3, TMEM121, HGH1, DOHH, C9orf16, TMEM106C, TMEM120A, FSD1L, RTFDC1, ASPSCR1, UCK2, ZC3H12C, C20orf27, SPATC1L, XYLT2, HSD3B7, DPH5, PLEKHA4, FAM96A, MRPL44, C17orf75, EPB41L4A, MRPL47, SMCO4, HOMER3, TMEM51, VNN3, DONSON, NKIRAS1, RGL1, SIPA1L2, PSMC3IP, IMPACT, STOML1, ARPP21, CFDP1, EPHA6, MKRN1, CHORDC1, OSGIN1, GPATCH8, ARHGAP26, EXOG, DIP2C, GPSM3, AIM1, AMMECR1, RAI2, LRRFIP2