GO:0005765

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lysosomal membrane

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

TMEM150C, AP3D1, ABCD4, NPC1, STX7, TLR3, GPR137B, ATP6V1G1, CLN5, FLOT1, TMEM63A, SNAPIN, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, ANXA2, PSAP, ANXA6, HSP90AB1, GNAI3, GAA, LAMP1, IGF2R, COL6A1, LAMP2, CFTR, HLA-DRB4, HLA-DOB, ACPP, CD1D, HLA-DPA1, ATP6V1B2, ATP6V1C1, UBA1, ENPP1, DPP4, HLA-DMB, GNA11, CD68, TRIM23, ECE1, NSF, SLC11A2, PSEN1, GNAQ, RAB5C, RAB7A, CLCN5, CLCN6, CLCN7, VAMP7, AP1S2, RAB2A, ATP6V0D1, AP1S1, GNB1, GNB2, UBA52, GNAI1, BLOC1S1, HLA-DRB3, GPLD1, DAB2, LRP2, IFITM3, CD164, AHNAK, AP1B1, CLN3, PLD1, TCIRG1, LAPTM5, STARD3, RHEB, MMD, HLA-DRB5, MARCH8, ABCC10, HGSNAT, LAMTOR1, RAB12, TLDC1, DRAM2, KIAA1324, SLC36A1, TECPR1, SLC26A11, OSTM1, SLC44A2, DRAM1, SLC15A4, RNF152, SLC38A9, DAGLB, ATP6V1C2, MFSD8, TPCN2, MARCH1, SPPL3, SPPL2A, HM13, SCARB1, GLMP, ABCA5, TMBIM1, BORCS7, ARL8A, AP2M1, BORCS6, VPS35, NEU1, P2RX4, LITAF, TMEM59, OSBPL1A, WDR11, TM6SF1, AP5M1, TMEM165, TMEM8A, GOPC, ATP13A2, TMEM106B, LMBRD1, ARL8B, TMEM9, ANKFY1, VTI1B, LAMTOR3, ATP6V1H, LNPEP, MYO6, LAMP3, HPSE, LAMTOR2, AP3M1, ATP6V1D

GO:0005768

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endosome

A vacuole to which materials ingested by endocytosis are delivered.

DSCR3, ARPC2, LEPROT, STX7, RAB11FIP3, PDCD6, VPS4B, VAMP4, VPS26A, RASSF9, PAK3, FLOT1, MYO1D, EGFR, NGF, TFRC, ANXA1, NTRK1, APP, FYN, ANXA2, ADRB2, NGFR, STS, HMGB1, IGF2R, ACE, EZR, FOLR1, RAB5A, MAL, S1PR1, LHCGR, CDK2, AVPR2, CLIP1, GPC1, TGFBR1, ADCYAP1R1, PRKCI, NSG1, ECE1, CRKL, CDKN1B, ATP1A2, CLCN5, RAB5B, RHOA, TGFB2, GRB2, LRP2, CAV1, CD164, TNK2, STX4, PLD1, RAPGEF1, KCNJ11, RFTN1, RABEP1, PKN1, WDR72, OCIAD2, TJAP1, MARCH8, STEAP4, RAB11FIP2, ARC, RABEPK, DGKH, ARRDC4, EXPH5, MARCH1, FRS2, SNX33, SORL1, ARRDC3, SYTL4, C9orf72, CCDC115, VPS35, SNX18, TM9SF2, ZFYVE21, PACSIN1, CHMP4B, ABCB6, OCIAD1, BET1L, PI4KB, SPAST, VPS29, SCOC, RAB21, BLOC1S6, ANKRD50, SNX9

GO:0005769

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early endosome

A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.

WASH1, NEURL1B, RHOD, NRP1, RAB29, STX7, TLR3, SIAH2, STX6, TRAK2, SNX3, DIAPH2, ATP9A, VPS26A, LRP6, FLOT1, STAMBP, LDLR, CD4, APOA1, APOE, APOA2, APOC3, TF, APOB, NTRK1, ANXA2, ADRB2, ADRB1, HSPD1, IGF2R, CFTR, GJA1, VCAM1, RAB5A, F2R, MAPK3, MAPK1, EPHA3, CORO1A, AKT2, PHB, NF2, MAP2K2, SLC11A2, NUMB, RAB5C, CLCN3, F2RL1, SNX16, RAB5B, CXCR4, ATP6V0D1, RHOB, RAB1A, RAP1A, OCRL, MAP2K1, NUCB1, PTP4A2, CLN3, RAB31, RAB32, RAPGEF1, EEA1, RABEP1, AOC3, HFE, CCDC93, RABGAP1L, LDLRAP1, WLS, PARM1, ZFYVE16, SIAH1, VPS8, COMMD1, NIPA2, PCSK9, ARRDC4, DNER, RIN3, TBC1D16, SORL1, PTP4A1, MIB2, ARRDC3, SGK3, ANKRD27, ALS2, VPS35, GPER1, KIFC1, DERL2, ACKR4, ANKFY1, VPS29, RABGEF1, RAB22A, SNX12, TRAK1, LAMP3, ATP11B, NISCH, CCDC53, MYO5A, LIPG, WASF2

GO:0005770

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late endosome

A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.

WASH1, STX7, SLC31A1, SLC31A2, LDLR, TF, NTRK1, LAMP1, IGF2R, LAMP2, IFNAR1, F2R, MAPK3, MAPK1, DDIT3, MAP2K2, HTT, SLC11A1, RAB7A, RAB9A, RAB27A, CLCN3, SNX16, CXCR4, RAP1A, ARF1, MAP2K1, CLN3, MTM1, SQSTM1, NBR1, PARM1, KIAA1324, MAGI2, ANKRD13A, PCSK9, SLC38A9, PIK3C3, WDR48, SPPL2A, RNF128, ABCA5, SLC9A6, ANKRD27, VPS35, PIK3R4, SDF4, TMEM59, OSBPL1A, DERL2, AP5M1, MAP1LC3A, ATP13A2, TMEM9, VPS29, RAB22A, KIDINS220, LAMTOR2, MYO5A

GO:0005771

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multivesicular body

A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.

CST3, CD74, LAMP1, TPT1, SLC2A4, GJA1, ZP3, RAB11A, BST2, SLC40A1, ATP13A2, HDAC6

GO:0005773

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vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

CD74, SLC11A2, STX4, NPRL3, STX3, GLB1L2, GGH

GO:0005774

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vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

RAB7A, NAPB, TMEM138, PCYOX1

GO:0005776

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autophagosome

A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy.

WASH1, TBC1D12, ULK1, IL1B, RALB, HTT, GABARAPL2, PIP4K2B, CALCOCO2, CLN3, SQSTM1, NBR1, RAB12, TP53INP2, TBC1D5, TP53INP1, OPTN, NRBF2, C9orf72, PIK3R4, MAP1LC3B, PEG3, GABARAPL1, MAP1LC3A, ZFYVE1, ATP13A2, UBQLN4, TBC1D14, RAB23

GO:0005777

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peroxisome

A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

AGPS, PEX12, ABCD4, GNPAT, ACOX3, SLC25A17, PEX14, IDH1, TRIM37, PEX11B, VIM, NUDT7, IDE, AGXT, SCP2, ABCD3, TKT, HMGCL, MPV17, CRAT, XDH, IDH2, HSD17B4, HRSP12, PEX3, ECH1, IDI1, ACOX1, ACBD5, HSDL2, TMEM135, LONP2, ZADH2, ACOT4, GBF1, FAR2, ACOX2, DHRS4, IDI2, MFF, PNPLA8, HAO2, PIPOX, AKAP11, CROT, GSTK1, KIAA0430, MYO5A

GO:0005778

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peroxisomal membrane

The lipid bilayer surrounding a peroxisome.

AGPS, PEX12, ABCD4, SLC27A2, GNPAT, SLC25A17, ACSL4, PEX14, PEX11B, HMGCR, MGST1, ABCD3, ACSL1, MAP2K2, ALDH3A2, HSD17B4, PEX3, ARF1, ACOX1, TMEM35, ACBD5, MAVS, ATAD1, RAB8B, FAR2, TTC1, DHRS4, PNPLA8, ACSL6

GO:0005779

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integral component of peroxisomal membrane

The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

PEX12, SLC27A2, SLC25A17, PEX11B, PEX3

GO:0005782

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peroxisomal matrix

The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.

NUDT19, AGPS, ACOT8, GNPAT, ACOX3, ECI2, IDH1, NUDT7, HSPD1, IDE, AGXT, SCP2, ABCD3, CRAT, HSD17B4, ACOX1, LONP2, ACOT4, FAR2, ACOX2, HAO2, PIPOX, GRHPR, CROT

GO:0005783

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endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

TMEM129, ELOVL7, KIAA0922, HAX1, RNF103, PLOD2, SCD, TOR1A, HSD17B6, MGST3, CLGN, PDZD2, NPC1, GPR37, P4HA2, INSIG1, HNRNPR, ATP8B1, SLC37A4, CALU, KIF1C, BNIP3L, PLIN1, PARK2, BRINP1, SYNCRIP, TPST2, ICMT, LRP5, PDCD6, MPDU1, ERN1, CLN5, LRP6, CRTAP, PPP1R15A, TRAPPC6A, ARL6IP5, STC2, TM7SF2, PDE9A, SRP72, ERLIN2, SEC31A, NDUFB8, VAPB, PSMG1, STAU1, TMEM50A, CYB5R3, ASS1, SERPINA1, CST3, FOS, HLA-B, APOE, APOC1, ALB, HMGCR, PRNP, VWF, TP53, APOD, CYP17A1, DBI, P4HB, THBS1, ITGA5, STS, HMOX1, FURIN, TRAPPC2, BCL2, MGST1, CYP2D6, TFPI, CLU, HSPA5, CYP19A1, P4HA1, PRKCSH, PLA2G2A, HSP90B1, POU2F1, IFNGR1, ATP2A2, PRKCA, PTPN2, XBP1, ATF6, VCAM1, CAST, MAL, ZP3, TGM2, PPIB, EEF1B2, HSD3B2, PLN, FKBP2, STOM, RPL10, CALR, CANX, PCSK6, EEF1D, ERP29, PDIA3, MIP, HLA-A, HLA-F, AVPR2, LRPAP1, ADORA1, S100A7, MAN1A1, PTGS2, THBS4, SOAT1, CHI3L1, MAP2K2, FDFT1, IFNGR2, DDOST, ANP32A, HTT, CRAT, SSR1, CASP4, TMED10, PSEN1, PSEN2, EMD, SERPINH1, LRBA, BCAP31, RAP1GDS1, PLA2G16, EPHA4, VCP, HADHB, TPD52, TMEM50B, PEX3, NPC2, RRAS2, DLG4, SLC35A2, NUCB2, TMF1, LRP2, SET, COL4A3, MAP2K1, CAV1, PRKCD, BAX, KCNA1, SREBF2, ASPH, GRIN2A, HYAL2, ANK3, DLG1, BNIP3, ARHGAP5, SEMA3B, DNAJC3, CLN3, PDE3B, SLC39A6, SQSTM1, PKD2, RAB32, MLEC, RCN2, PIGH, ITPR3, ITPR1, KCNJ11, EMC2, SLC39A14, RRS1, PDIA6, EBP, RCN1, TMED2, DHCR24, PUM3, SEC23A, NSDHL, MSMO1, ADIPOQ, EXT1, PTGIS, CYP51A1, AOC3, CPEB4, TMEM132A, PGS1, CCDC88A, CERKL, GPAT3, ORMDL2, HS1BP3, MEST, PIGG, CDKAL1, HACD4, ATL3, MCTP1, PTRF, SLC27A1, TXNDC11, CBLN3, CRELD2, HACD2, CERS6, IKBIP, PGAP1, SV2A, FA2H, LPCAT2, EPM2AIP1, SLC36A1, TMC6, GRINA, SYVN1, MTDH, GPAT4, KTN1, SGMS1, SLC26A11, ERO1B, TRAPPC5, P3H2, SULF2, SULF1, SGPP2, DNAJC10, MSRB3, HACE1, ZDHHC14, ABI1, GPC2, CRIPAK, UBE2J2, PHTF2, CERS5, CISD2, POMGNT2, SUMF1, PCSK9, SLC38A9, ATL2, KCNG3, FIBIN, STT3B, HM13, MRAP, AGR3, TRPM4, RNF128, RHBDD1, CEMIP, ZFAND2B, APH1B, SELM, PIEZO1, EDEM1, SORL1, KIFAP3, CDS1, EXT2, PTP4A1, MR1, TMEM203, CCDC47, CREB3L1, APH1A, FAF2, YIPF6, MRAP2, VMP1, ERO1A, VCPIP1, DNAJC1, DHRS1, DGAT2, SMIM14, PANX1, SRPK1, GPX7, SEC62, GPER1, PLIN2, PKMYT1, CHP1, SIGMAR1, MGST2, OLFM1, CIB1, VIMP, CCDC3, INPP5K, ELOVL1, EBPL, SCAPER, PLA2G12A, EDEM3, DERL2, ELOVL4, GABARAPL1, TMX4, EHD4, TOR3A, ELOVL6, FNDC4, ZDHHC6, YTHDC2, ALG9, METTL7A, PLEKHF2, REEP1, CERS4, ZFYVE1, APMAP, ABCB6, CD320, RTN4, MAN1C1, AGPAT3, STAU2, UFSP2, NDFIP2, TMEM30A, CLN6, SMPD4, ELOVL5, UGGT1, ERAP1, HACD3, VAPA, STIM2, RRBP1, ADAMTS9, DPM3, DHCR7, SPAST, CTSZ, DNAJB9, SEL1L, SEC63, USP25, ZDHHC2, MAN1B1, DSE, NRXN1, PYCARD, TMCO1, PHTF1, BOK, STUB1, ANGEL1, MINPP1, POMP, CNPY2, ATP11B, ZDHHC9, GOLT1B, TMED3, MYO5A, HYOU1, TBL2, PCDHA2, PCDHA1, TRAPPC1, IER3IP1, CPQ, POMT1, SLC30A1

GO:0005784

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Sec61 translocon complex

A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events.

SSR4, BCAP31, ARL6IP1

GO:0005785

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signal recognition particle receptor complex

A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex.

SRP9, RP9, SRPRB

GO:0005786

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signal recognition particle, endoplasmic reticulum targeting

A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.

SRP72, SRP14, SRP9, SRP54

GO:0005787

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signal peptidase complex

A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space.

SPCS2

GO:0005788

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endoplasmic reticulum lumen

The volume enclosed by the membranes of the endoplasmic reticulum.

RNASET2, TOR1A, SLC27A2, P4HA2, SELENOF, CRTAP, H6PD, F8, F2, SERPINA1, PDGFB, GCG, INS, CD4, COL1A1, COL3A1, APOA1, APOA2, BGLAP, PDGFA, APOB, COL5A2, P4HB, THBS1, COL1A2, COL4A2, STS, HSPA5, COL11A1, COL6A1, COL6A2, COL6A3, F5, PDIA4, P4HA1, COL11A2, PRKCSH, HSP90B1, ARSA, ARSB, COL9A1, COL5A1, PPIB, COL8A2, COL5A3, CALR, CANX, CFP, ERP29, PDIA3, PTGS2, COL15A1, COL18A1, WNT5A, SERPINH1, ARSD, CTSC, WNT3, B2M, COL4A3, PLAUR, COL10A1, COL14A1, COL16A1, DNAJC3, OS9, COL4A6, RCN2, GAS6, PDIA5, GANAB, PDIA6, RCN1, TOR2A, COL13A1, ERAP2, KDELC1, CES3, ARSK, ADAMTSL4, KDELC2, COL23A1, P3H2, DNAJC10, TOR2A, SUMF1, CYP2W1, GPX8, GBF1, MYDGF, FKBP10, ERO1A, COL21A1, GPX7, COL12A1, ERP44, CNPY3, TMEM43, EDEM3, PDGFD, WNT5B, TOR3A, SPON1, PDGFC, FKBP14, CLN6, UGGT1, ERAP1, CTSZ, DNAJB9, GHRL, ADAMTS7, COL17A1, ADAMTS5, MINPP1, HYOU1, FKBP7, WNT6

GO:0005789

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endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

TMEM129, ELOVL7, TMEM189, HACD1, RNF103, WRB, SLC33A1, PLOD2, SDCBP, SCD, COPE, GOSR2, ABCD4, PTGES, MGST3, CLGN, SLC27A2, SURF4, SPTLC2, GRM6, GPR37, TLR3, INSIG1, FLRT2, CYP26A1, ASNA1, KDELR3, SLC37A4, CALU, AHCYL1, FADS1, ACSL4, ICMT, TRIM13, PDCD6, MPDU1, SEC22B, ERN1, PPP1R15A, SC5D, DHRS3, ARL6IP5, TM7SF2, SEC24D, TMCC1, ERLIN2, SEC31A, CLSTN1, CSPG5, VAPB, CTDNEP1, ABCA1, CDS2, FADS2, CH25H, CYB5A, CYB5R3, EGFR, TGFA, CD4, HMGCR, APOB, CYP1A1, CYBB, CYP17A1, CYP2E1, UGT2B4, EPHX1, CYP3A4, CYP21A2, STS, HMOX1, UCHL1, BCL2, MGST1, CYP2D6, HSPA5, CYP2A6, CYP19A1, SFTPC, CYP2C9, PSKH1, HSD3B1, PLA2G2A, HSP90B1, FOLR1, AREG, CD1D, ATP2A2, GJA1, XBP1, SRD5A1, ATF6, CYP2B6, CYP3A5, OSBP, AADAC, PTGS1, KDELR1, CYP3A7, HSD3B2, FKBP2, CANX, HSD11B1, SRI, SRD5A2, FMO4, ACSL1, PTGS2, G6PC, SOAT1, GJC1, SREBF1, HSD17B2, FDFT1, PIGA, GGCX, IFNGR2, DDOST, PMEL, PTGDS, TMPO, TMPO, SSR1, NOTCH1, STT3A, PLA2G4A, ARCN1, LSS, PTDSS1, PITPNB, PCYT1A, CASP4, TMED10, PSEN1, PSEN2, RAB9A, BCAP31, ALDH3A2, VAMP7, COPA, ATXN3, VCP, SEC13, HSD17B7, ANTXR2, SEC61G, CDC42, RAB2A, RHOA, DAD1, COPZ1, RAB1A, RAC1, EIF5A, PIP4K2B, HSD11B2, FKBP3, FKBP4, PLOD1, DST, CAV1, PLAUR, NOTCH2, TYRO3, PIGF, BAX, DMPK, GALNT2, GALNT1, SREBF2, ASPH, LRMP, DLG1, PLD1, OS9, FKBP5, PKD2, MLEC, PIGH, NFE2L1, SQLE, PDIA5, ITPR2, ITPR3, ITPR1, LPIN1, SPCS2, ARL6IP1, RAB3GAP1, PDIA6, EBP, TMED2, RHEB, DHCR24, SEC23A, NSDHL, MSMO1, EXT1, PTGIS, CYP1B1, CYP51A1, DUOXA1, DUOXA2, TMEM132A, PIGY, TMEM259, GPAT3, HSD17B12, TTMP, MEST, PIGG, ALG10B, WLS, CDKAL1, ATL3, REEP3, ERAP2, LPCAT3, SLC27A4, LRRC8B, TXNDC11, AGTRAP, MOXD1, SHISA2, LCLAT1, SEZ6L2, CYP2R1, HACD2, CERS6, CYP4V2, MBOAT2, IKBIP, ILDR2, PGAP1, FA2H, LPCAT2, ERMP1, TMC6, CYP2U1, PIGW, TMED4, SCD5, SYVN1, MTDH, GPAT4, KTN1, SLC51A, ANKLE2, ERO1B, GPSM1, SGPP2, RDH10, ARMC10, UBE2J2, CERS5, CISD2, MFSD2A, POMGNT2, TMEM178A, SVIP, ATL2, MCFD2, CYP2W1, ABHD4, PIGX, DNAJB14, RDH11, MARCH1, HM13, MRAP, LRRC8C, RHBDD1, NUP210, RAB2B, TMEM170A, PIEZO1, PIGC, SLC9A6, LPGAT1, PIGK, CDS1, EXT2, MR1, YIPF5, PIGT, TMEM203, NCLN, ERGIC1, PNPLA2, FKBP10, CREB3L1, APH1A, RHBDF1, MRAP2, ERO1A, SEC22A, SEC16B, FAR2, DNAJC1, CARD19, MBOAT7, NECAB3, DGAT2, NOX5, SMIM14, PANX1, ERGIC2, LMF1, SEC62, PCYT2, SDF2, FMO2, GPER1, PKMYT1, MGLL, SIGMAR1, MGST2, DHRS9, VKORC1, APOL2, ERP44, DHRS4, G6PC3, APOO, ALG8, TMEM106C, ELOVL1, TAPBPL, EBPL, SEC11C, OSBPL8, OSBPL6, EPT1, LNP, DERL2, EIF5A2, RAB1B, LMAN2L, XYLT2, HSD3B7, RAB3GAP2, PIGU, CLSTN2, ELOVL6, ZDHHC6, ALG9, RNF121, SEC61A2, CERS4, SLC28A3, CYP3A43, GBA2, ABCB6, ALG13, PNPLA8, NOX4, RTN4, CYP26B1, UBQLN4, SERINC1, AGPAT4, AGPAT3, PNPLA3, SLC35D1, FKBP14, CLN6, SMPD4, FKBP11, ELOVL5, ERAP1, FMN2, FLRT3, FLRT1, SEPN1, JKAMP, VAPA, STIM2, DPM3, PEMT, DHCR7, SPAST, DNAJB9, SEL1L, VTI1B, SEC63, MAN1B1, C14orf1, ACSL6, AMFR, RAB21, NDRG4, BOK, SSR3, CYP8B1, PLA2G4C, MAPK8IP1, RCE1, ERGIC3, MYRF, ZDHHC9, TMED5, RTCB, TMED3, PCYT1B, SRPRB, IER3IP1, ALG6, COPG1, FKBP7, POMT1, SAR1B, CEPT1

GO:0005790

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smooth endoplasmic reticulum

The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.

MYO1D, APP, TH, HSPA5, PPIB, CALR, CANX, ERP29, SRI, PSEN1, PRDX4, DNAJC3, SLMAP, RYR3, SYVN1, RYR2, GBA2, MAPK8IP3, HYOU1

GO:0005791

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rough endoplasmic reticulum

The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.

STAU1, BGLAP, CYBB, APP, HSPD1, CCL2, ARSB, CA4, MT3, CANX, SNCA, PTGDS, ADCYAP1R1, PSEN1, EPHA5, SEC61A1, NUCB1, TRAM2, TMEM97, CDKAL1, PCSK9, SPPL3, HM13, CCDC47, SEC62, FKRP, LIN28A, RANGRF, SLC7A11

GO:0005793

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endoplasmic reticulum-Golgi intermediate compartment

A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.

SURF4, SEC22B, STK17B, FN1, P4HB, HMGB1, HSPA5, PTPN2, CA4, KDELR1, MAN1A1, TMED10, SERPINH1, IST1, NUCB2, NUCB1, PDIA6, TMED2, RGMB, GBF1, MYDGF, ERGIC1, SCYL1, CCDC115, CHP1, ERP44, LMAN2L, SLC35C2, RAB6B, UGGT1, DICER1, TMED5, TMED3

GO:0005794

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Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

GOLGA8A, HIP1, IPO5, PIK3C2A, GOLIM4, BTN3A3, PLPP3, BHLHE40, COPE, AP3D1, GOSR2, ADAM10, RAB29, NPC1, SCAMP2, ARPC2, PLSCR1, LEPROT, HDAC3, AKR7A2, B4GAT1, ATP8B1, SPRY1, ITM2A, STX6, CALU, KIF1C, PARK2, ADCY3, TPST1, NMT2, TLR2, TPST2, DIAPH2, FAM20B, OBSL1, VAMP4, CLN5, STX11, LRP6, RP2, SCRG1, PPP1R15A, AP1G2, STC2, PDE9A, ZFPL1, CSPG5, KIF20A, TNKS, VAPB, SNAPIN, PSMG1, LARGE, ABCA1, CXCL14, SERPINA1, NRAS, LDLR, HLA-B, COL1A1, CRYAB, APOE, ALB, ESR1, RAF1, APOB, PRNP, CYBB, APP, DBI, GALT, LYN, CD14, ITGA5, GNAI3, STS, SRGN, HSPD1, CLU, PSKH1, PTHLH, BMP1, B4GALT1, ARSB, CD44, CD36, CPE, GJA1, SYN1, TCP1, ARF4, ATF6, LIG1, VCAM1, FUT1, CCNA2, SYT1, ZP3, FGF7, FGFR2, OSBP, FUT4, GAL, CA4, XPA, PTGS1, IGFBP6, F2R, MAPK3, CALR, MAPK1, CTGF, HLA-A, AVPR2, GDI1, STIP1, MAN1A1, CTNNA1, MAP2K2, PPARG, SNCA, PLA2G5, PMEL, ID1, AQP2, PTGDS, HTT, PLA2G4A, ARCN1, SLC1A6, CSNK1D, TGM4, FASN, PSMB3, TMED10, PSEN1, PSEN2, TSC2, GDI2, ERF, LRBA, RNF144A, PPT1, RAB7A, RAB27A, CAV2, CLCN3, MSH6, AP3M2, EPHA4, EMP2, F2RL1, AP1S2, AP3S2, GABARAPL2, ZP1, B2M, AP1S1, NCS1, RAB11A, RAB1A, GRB2, DYNLT1, SLC35A2, SLC35A1, NUCB2, TMF1, ARF5, LRP2, ATP2C1, APBA1, SP3, MAP2K1, NUCB1, ICA1, GOLGA2, MGAT2, GALNT2, GALNT1, BST2, FUT2, ANK3, DLG1, STRN3, CLN3, PDE3B, PLD1, GOLGA4, PICALM, SNX1, PWP1, PTCH1, CUX1, CDK13, CTTN, NEDD9, GANAB, CUL7, NAA25, RAB3GAP1, SLC39A14, PRKD1, TMED2, TLR1, TAF11, MMD, TRIP11, MAPRE1, SLC1A5, EXT1, AOC3, TMEM132A, GNPTAB, CCDC88A, GLYR1, CERKL, LARP7, PREPL, ESCO2, WDR44, RABGAP1L, MANEA, ARHGAP21, WLS, GKAP1, PDE4DIP, GLT8D1, LAMTOR1, AFTPH, CBLN3, PARM1, DRAM2, CRELD2, FGD6, BEND5, TMC6, GRINA, CCDC91, FGD2, SERINC5, CAND1, HOOK3, SLC26A11, CEP57, ZDHHC17, HID1, P3H2, ARL17A, SULF1, FAM20C, SCYL3, XRN1, MAML2, VPS52, NLGN1, ASCC3, GALNT4, MINK1, ARFGAP2, GOLM1, PCSK9, TNRC6A, GLIS3, USP32, SGMS2, FIBIN, MPLKIP, SLC35G2, BICD2, TRPM4, PXYLP1, RNF128, ATP8B4, SECTM1, SELM, SEC14L1, FAM3C, GBF1, TOPBP1, SORL1, KAT6A, GOLGA1, PCSK5, RPGR, KIFAP3, GLG1, ARHGEF2, ATP6V0A1, EXT2, TMBIM1, JAKMIP2, APH1A, OPTN, RAB39B, C11orf24, PERP, BICD1, SCYL1, FGD4, ARAP1, PASK, ERGIC2, LMF1, OSBPL9, GPER1, MPHOSPH9, PKMYT1, FEZ1, LITAF, CDC6, CIB1, ARID3A, MAPKAP1, SOST, SDF4, TMEM43, PDCD10, DUSP26, TIPIN, JAM3, OSBPL11, FUT8, RAB34, PRKD2, PLA2G12A, SPRY4, CHST5, CHST6, ADAM19, GABARAPL1, RAB1B, LMAN2L, ACBD3, FZD8, DDX31, AKTIP, FKRP, TMEM165, CWC22, GOPC, ABCB6, ARFGAP3, SLC35C2, ASH1L, RAB6B, NDFIP2, TMEM30A, HAUS2, SMPD4, ZDHHC7, AATF, BET1L, STMN3, CLIC5, EHF, GRHL1, TBC1D14, STARD9, VTI1B, ZDHHC2, GNPTG, GGA2, GGA1, MAN1B1, MYH2, DSE, MTUS1, MYO6, PLAGL1, BOK, SYNRG, NDRG2, MACF1, HDAC5, ZNF148, AKT3, RUVBL1, ERGIC3, ITM2B, SLC35A3, ATP11B, CRYL1, AP3M1, ZDHHC9, TMED5, TMED3, TRRAP, MYO5A, CEP83, IER3IP1, LIPG, CPQ, COPG1, SLC30A1, DUSP10

GO:0005795

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Golgi stack

The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.

RAB27B, NSF, OCRL, MGAT2, GALNT2, CLN3, COG2, DNMBP, LPCAT2, SULF2, SULF1, GBF1, VCPIP1, VRK1, RAB34, ZFYVE1, NSFL1C

GO:0005796

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Golgi lumen

The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.

AGRP, GOLIM4, NCAN, HS3ST1, SDC3, GPC4, CSPG5, F2, TGFB1, NGF, CGA, LHB, INS, BGLAP, VTN, DCN, SOD3, FURIN, DEFA4, VCAN, MUC1, SDC1, OGN, BGN, MMP11, PCSK6, SDC4, SDC2, GPC1, WNT5A, MMP14, MMP16, LUM, WNT3, MUC5AC, HSPG2, MUC3A, FMOD, PPIL2, GAS6, MUC21, CSPG4, GPC2, MUC20, MUC15, PCSK5, MUCL1, BCAN, MUC4, OMD, SDF4, WNT5B, BLZF1, MUC13, GPC6, WNT6

GO:0005797

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Golgi medial cisterna

The middle Golgi cisterna (or cisternae).

HID1, TMEM59

GO:0005798

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Golgi-associated vesicle

Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.

ADAM10, AP1G2, GNRH1, TYR, OCRL, NUCB1

GO:0005801

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cis-Golgi network

The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.

GOLIM4, RAB29, KDELR1, PIK3R1, CTGF, TMED10, LIMK2, NUCB1, GOLGA2, TRIP11, HOOK3, GBF1, YIPF6, SCYL1, SLC35C2, PHTF1, ANGEL1, TMED5

GO:0005802

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trans-Golgi network

The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

GSAP, RAB29, SCAMP1, STX6, ATP9A, SOD3, FURIN, IGF2R, PAM, CA4, LAP3, VAMP7, SNAP25, RAB11A, RAC1, AP2B1, VAMP2, ARF1, ATP2C1, OCRL, NUCB1, STX4, CLN3, GOLGA4, RAB32, POSTN, PRKD1, TGFBI, TRIP10, TJAP1, WIPI1, FNBP1L, WLS, DENND5A, CNST, KIAA1324, CHST4, PIFO, GBF1, SORL1, GOLGA1, OPTN, YIPF6, BICD1, ARAP1, FNBP1, GPER1, INPP5K, CHAC1, RBFOX1, SMPD4, SCOC, GGA2, RAB21, CHST2, SNX9, ARFGEF2

GO:0005811

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lipid particle

An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

PLIN1, ACSL4, CYB5R3, GAPDH, ANXA2, FABP4, ALOX15, G0S2, ALDH3B2, LSS, RAB5C, RAB7A, BCAP31, IRAK1, VCP, PLIN5, CAV1, LIPE, RAB3GAP1, NSDHL, LPCAT2, PNPLA5, SPG20, HSD17B11, ABHD4, ABHD5, GBF1, PNPLA2, ATG2B, FAF2, DGAT2, PLIN4, PLIN2, SIGMAR1, AIFM2, REPIN1, METTL7A, PNPLA3, SPAST, PRPF19, STARD13, HILPDA

GO:0005813

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centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

C4orf47, DCTN6, PLK4, ELL2, CHEK1, AURKA, PPP1R12A, ARHGEF10, SMAD7, CETN3, DYNC1LI2, WDR62, SSNA1, NUDT21, ROCK2, OBSL1, RAB11FIP3, VPS4B, USP2, OFD1, RAD51D, HAUS5, CEP152, CCNB2, PCNT, SNAP29, DDAH2, GNAI2, CDK1, NPM1, GNAI3, G6PD, PCNA, SKI, PRKAR2A, CCNB1, NME1, ZNF12, PRKACA, TCP1, MAK, TUBG1, CDK2, APC, MCM3, PSMA1, PSMB5, MARCKS, CDC27, CDC25B, CLIP1, PRKAR2B, CTNNB1, MDH1, ID1, ACTR1B, SLC1A4, RANBP1, CSNK1A1, CSNK1D, MAPKAPK2, CENPF, PSEN1, PSEN2, GSK3B, CCT8, BRCA2, NEK2, NEK3, PLK1, IST1, NUP107, ATP6V0D1, CALM2, RAB11A, GNAI1, DYNLL1, SKP1, CDK6, KIF23, ID2, PDE4D, CAMSAP2, MZT1, CCDC15, CDC20, DYNC1I2, XRCC4, UNC119, DCTN2, CKAP5, DCTN1, DYNC1H1, ESPL1, CHD4, CUL7, FAM175B, PCM1, STIL, MAPRE1, CCDC85B, PKN2, CSPP1, KIZ, ERCC6L, FAM161A, CCDC14, CEP55, ODF2, SGOL1, CEP78, CEP170, UBR4, CROCC, PDE4DIP, CEP135, TTC19, MZT2A, CCDC81, NEK10, HAUS6, PCGF5, SDCCAG8, HOOK3, CEP57, MIB1, BBS7, SIRT2, CKAP2L, CNTROB, AHI1, NIN, C7orf31, CEP120, POC1A, VPS37A, BBS1, CEP70, TTC8, MPLKIP, MDM1, POC1B, NEK9, FBF1, GSG2, CKAP2, PIBF1, IFT81, TOPBP1, NDRG1, RPGR, KIFAP3, MED12, CLUAP1, SYTL4, HAUS1, TUBGCP3, TBC1D31, HOOK2, MVB12A, ZNF274, MASTL, ZFYVE19, RITA1, MARK4, IFT74, CEP19, FOPNL, NEK1, ALS2, KIF20B, CEP89, MPHOSPH9, FEZ1, CIB1, HAUS7, NCAPG, SLF1, CCDC77, DCTN5, KATNB1, IFT27, SORBS1, LRRCC1, CEP44, NDEL1, SPATC1L, CCDC8, TSPYL2, IKZF4, RGCC, HAUS4, AUNIP, PHAX, TTC12, MEAF6, CENPJ, MKKS, CYLD, IFT46, MBNL1, KIF15, RAD18, DCAF13, RNF19A, HAUS2, MKS1, NDE1, AATF, PLK2, DTL, ITSN2, CAMSAP3, SLAIN2, WDR35, WRAP73, UXT, SPAST, FBXL7, NDRG2, CDC14A, PROCR, B9D1, USP20, RABGAP1, KIF3A, HSPB11, NME7, ATP6V1D, MAD1L1

GO:0005814

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centriole

A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.

WASH1, PLK4, AURKA, CETN3, WDR62, CEP104, OFD1, RP2, CEP152, PCNT, HSPA1A, HSPA1B, TOP2A, HSPA6, TUBG1, CAPG, CCNF, HTT, PCM1, STIL, CEP55, ODF2, CEP170, CROCC, CEP135, CEP128, SDCCAG8, SIRT2, CNTROB, AHI1, NIN, CEP120, POC1A, MDM1, POC1B, FBF1, TUBGCP3, WDR34, CEP19, CEP89, MPHOSPH9, LRRCC1, CENPJ, MKS1, PLK2, STARD9, WRAP73, TUBD1, TSKS, CEP83

GO:0005815

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microtubule organizing center

An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

NUDT21, SPAG9, BUB1B, RAB11FIP3, TACC1, DAB1, FLOT1, TACC2, LATS1, NR3C1, KRT18, G6PD, PSKH1, ATF4, MAPK1, SLC1A4, PPP4C, CDC42, RPS7, RELB, PTK2, RAD51, LRMP, MLLT11, RBM39, CASP8, SLMAP, DLGAP5, RAB11B, CSPP1, FAM110C, KLHL12, LRIF1, ERCC6L2, FRY, PPP4R3A, CCDC141, CEP128, CENPU, HAUS6, RBBP6, PXK, HOOK3, C2CD5, MCPH1, KIF18A, FAM110B, NEK7, PDCD6IP, NUDCD2, SPDL1, IFT43, AJUBA, BOD1, SCYL1, MARK4, RPP25, KIFC1, UBXN6, TRIOBP, TAF1D, NEK6, LATS2, RASSF1, CLIC5, FNIP2, LRWD1, AKAP11, MTUS1, NDRG2, EXOC7, RUVBL1, TLN1, LAS1L, ARFGEF2

GO:0005816

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spindle pole body

The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome.

MAP2K1

GO:0005819

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spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

AURKA, MID1, BIRC5, PRC1, ZNF207, HAUS5, KIF20A, NR3C1, HSPB1, RB1, ERCC2, CDC27, AKT1, TTK, MYH9, CSNK1D, CENPF, ANXA11, KIF11, PLK1, TERF1, DYNLT1, CBX1, KIF23, MZT1, NSUN2, CDC20, MAP2K5, CBX3, SEPT6, NEDD9, SEPT2, RPS6KA2, MAPRE1, SEPT7, CSPP1, MAP7D1, CEP170, RIF1, MZT2A, PSRC1, MAEA, HAUS6, SIRT2, SHCBP1, GSG2, ARHGEF2, PTP4A1, TUBGCP3, AURKB, CHAMP1, HAUS7, VRK1, DIDO1, KIFC1, NUP85, NDEL1, HAUS4, ACOT13, CYLD, KIF15, FMN2, KLHL42, SPAST, FBXO5, MTUS1, TPX2, PRPF19, PIN4, INVS, FAM96B, SPIN1, MAD1L1

GO:0005826

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actomyosin contractile ring

A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis.

MYH9, MAEA, ANLN, MYH2

GO:0005827

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polar microtubule

Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart.

TUBG1, CUL3, TUBGCP3

GO:0005828

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kinetochore microtubule

Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation.

KNTC1, RAB11A, KIF18A

GO:0005829

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cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

UBA6, CNOT1, FABP12, WIPF3, UNC119B, WASH1, BBIP1, ACOT7, MYO1C, AIP, RHOD, LGALS8, PSMD11, PSMD12, ATOX1, DFFA, PIK3CD, DCTN6, WASL, EML1, IGF2BP3, PIK3C2A, PLK4, EXOC5, KPNA3, SDCBP, KPNA4, TRIM38, PPP6C, FBP2, UBE2C, ACACB, PDXK, SOCS2, DPYSL4, SOCS3, ARHGAP33, DYNC1I1, COPE, CCS, GOSR2, IRS4, ITGB1BP1, RIOK3, MAP2K7, PDCD5, CHEK1, NDC80, NRP1, OPLAH, BACH1, IRF6, TAX1BP3, CASK, AURKA, RAB29, PPP1R12A, AZIN1, XPO1, PIP5K1B, ARHGEF10, SYNJ2, PFAS, ANKRD28, SMAD7, FYB, KPNA5, ARPC2, ARPC3, POLR1C, PLSCR1, AXIN1, SMAD9, GSTA4, KMO, NPHP1, MAPK13, OGT, PMM2, POLR3G, INPP4B, MID1, HDAC3, BIRC5, GYG2, NUPL2, CFLAR, SOCS1, PHGDH, ARHGAP6, IRAK2, DYNC1LI2, PSMD3, SIAH2, MAP3K7, EEF1E1, RIPK2, RASA4, SYNJ1, EIF4G3, AKR7A2, BCL2L11, FOXO3, SMAD6, AKAP10, SPRY2, SPRY1, CHMP2A, PRC1, RGS10, BUB1, BUB3, GSTZ1, CYTH3, STX6, SGTA, SSNA1, NRDC, AHCYL1, PDE6D, RAD21, PPP1R12B, BNIP3L, PLIN1, PARK2, SPAG9, PIP5K1C, SNX3, MGEA5, SORBS3, GMDS, NMT2, BUB1B, EIF4E2, EXOC3, PDE8A, JAK2, PRMT3, UGDH, CTNND1, PFKFB2, EIF5B, DIAPH2, DNAJA2, NBN, NOL3, WDR1, ROCK2, ATG13, RAB11FIP3, CNOT3, DNAJB6, HMMR, ATP6V1G1, VPS4B, FLNB, ULK1, VPS26A, PSIP1, SRSF10, GMNN, CLN5, BANF1, DAB1, SKAP2, PRKRA, CRCP, LYPLA1, OFD1, PPM1B, PPP1R15A, EIF3J, PSMD10, TRAPPC6A, IDH1, STAM2, TNFSF13, ALDH1L1, RASSF9, PAK3, PDE5A, PDE9A, BEST1, SRP72, DDAH1, ALDH1A2, ATG12, PLEKHG5, MYO1D, SEC24D, FARP2, GLS, HAUS5, RHOBTB3, TRIM37, AP2A2, SEC31A, CEP152, FAM13A, UPP2, CCNB2, MFN2, OAZ2, ZWINT, KIF4A, PDE8B, TNKS, PGLS, PAPSS2, SMC2, PARN, PCNT, DUS4L, CNOT4, NFATC1, ATP6V1G2, BAG2, CRYZL1, AIFM1, LATS1, DDAH2, NUDT3, CH25H, PTTG1, BCL10, CCNE2, ADH1B, LDHA, ALDH1A1, DHFR, GSR, PNP, PGK1, AK1, ADA, CA2, ASS1, A2M, FOS, MYC, KRAS, IL1A, IL1B, CRYAB, LMNA, APOA1, APOA2, RBP4, GC, FTL, FTH1, MT2A, RAF1, ALDOA, APOB, TK1, TUBB4A, GAPDH, TP53, HSPB1, TYMS, GNAI2, APP, S100A8, ISG15, PCCA, EIF2S1, RPLP1, RPLP2, RPLP0, JUN, FABP3, PRKCB, UROD, FYN, CDK1, S100A9, S100A6, EIF4E, ENO1, GPI, NPM1, TPM3, SERPINE2, TH, LDHB, GPX1, ANXA2, CA3, PFN1, BPGM, APRT, EPRS, HSP90AA1, GALT, HNRNPC, LYN, TPM2, FH, NGFR, HSP90AB1, ASNS, GSTA1, VIM, RPS17, RPSA, ENO2, GSTP1, QDPR, RBP1, FBP1, GSTM1, TPM1, CLTA, HMOX1, CTSH, FGR, ALOX5, UCHL1, ALDOC, UBC, TRAPPC2, SULT1A3, HSPA1A, HSPA1B, GLI2, GLI3, RAP2A, CCL3, AR, BCL2, TXN, MAPT, PRKAR1A, CD28, HSPD1, THRA, CLU, IRF1, PNMT, SLC2A1, UMPS, PYGM, BCR, LAMP1, FGFR1, G6PD, PC, DMD, MTHFD1, CDK4, ODC1, HARS, CKB, ACTN1, MYL4, XRCC5, CFTR, EEF2, ALAD, LCP1, TNNT1, GYS1, PRKAR2A, ENO3, HSD17B1, FDPS, PKM, HSP90B1, CCNB1, MYL6B, SLC2A4, SNRPB, TYR, IDE, DARS, JUP, FABP4, AKR1B1, RAC2, GSPT1, EZR, FOSL1, HPGD, VAV1, NME1, NQO1, RPS2, CHN1, ALOX15, PFKFB1, CBR1, GNB3, PLCG2, FAH, STMN1, HSPA6, RHOQ, HMGA1, PRKCA, GJA1, SYN1, PRKACA, DES, AMD1, CTPS1, PFKL, PSMC3, TCP1, RPL35A, ARF4, RPL7, RPL17, PGAM1, MYL12A, HK1, POLR2E, TNNI3, SRM, NFKB1, NCF2, TYMP, RAB3B, RAB5A, PSMB1, CAPN3, CAST, RASA1, PDC, PTMS, GSTM3, ATP6V1B2, ATP6V1C1, FLNA, TNFAIP3, SAT1, COMT, TGM2, OSBP, PCMT1, RPS4Y1, GART, PAICS, UBA1, NME2, CALB2, TUBG1, JAK1, AHCY, EIF4B, ITPKA, DTYMK, RRM1, IL32, CHM, EEF1B2, MYL9, CDK2, APC, MPST, FAS, DNAJB1, DNAJB2, MT3, PSMA1, PSMA2, PSMA3, PSMA4, CTNNA2, RPL13, CHML, TARS, ZFP36, MAPK3, RPL10, DCK, CAD, CALR, PIK3R1, PSMB8, PSMB9, PSMB4, PSMB5, GSTM2, ABCD3, TMOD1, MAPK1, TPP2, IMPA1, CTGF, EPHB2, TKT, CASP1, NOS3, LMOD1, EEF1D, PRDX6, BLVRB, RPL12, CMPK1, PEBP1, PPP2R1A, CDC27, CCND2, CDC25A, CDC25B, CDC25C, ADSS, ADSL, CLIP1, SRI, GSTT1, CORO1A, GDI1, S100A7, MAT2A, PRKAR2B, RRM2, DNAJA1, AKT1, AKT2, YWHAB, SFN, PRDX2, GK, DCTD, GBP1, GBP2, CTH, MCM7, SHMT1, HSPA1L, HSPA4, CTNNA1, CTNNB1, RPL22, CBS, PCK1, IRS1, AGL, MYH9, ACTN2, DDIT3, MYH11, GLRX, CHKA, PSMC2, MAP2K2, RPL4, NUDT1, PGM1, PPP1CC, SREBF1, GMPR, GPX4, SRP14, TGFBR2, PPARG, TALDO1, SNCA, CDKN1A, CCT6A, NNMT, PSMB10, ADH7, RPL13A, STAT3, MDH1, EIF2S3, RGS2, UBA7, CSK, MAP3K8, PRKCI, ACTR1B, STAT5A, AKR1C3, ARHGAP25, PIK3CA, PIK3CB, EPS15, RPS27, ABL2, RPL35, CDKN2B, CDKN2C, HTT, MTHFR, SYK, NAMPT, PSMC4, MAPK8, MAPK9, PHKA2, PHKA1, RANGAP1, CRKL, NSF, CDKN1B, NOTCH1, IER3, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, MAP1B, GNPDA1, YAP1, IQGAP1, PLA2G4A, CAPZB, EIF1AX, ALDH1A3, RPL29, ZFP36L2, XDH, LIMS1, ARCN1, GCLC, GCLM, CD151, TRAPPC10, CSNK1A1, CSNK1D, IDH2, PIK3CG, MAPKAPK2, ALDH9A1, RPL34, FASN, DHPS, CCT3, ALDH7A1, INPP1, CENPA, CENPF, SRP9, UBE2A, PCYT1A, SARS, PPM1F, CSNK1E, STAR, PSMB3, FHIT, RANBP2, RGS3, RGS4, RGS7, TSC2, GSK3B, MTHFS, GMPS, MRE11A, HNMT, GDI2, SERPINB9, ERF, METAP2, KNTC1, PPT1, RPL14, CCT8, RAB7A, RAB9A, FABP6, PLCD1, DUSP3, BCAP31, TPMT, IRAK1, PSMD7, STAT5B, NEK2, UBE2E1, PGD, KPNA2, KPNA1, RAP1GDS1, JAK3, MAP2K6, ARHGDIA, ARHGDIB, STAT2, KIF11, HRSP12, CAPZA1, PLK1, ARFIP1, MVD, COPA, AP2S1, POLR2K, PLA2G16, IST1, RARS, ATXN3, CACNB3, OAZ1, YARS, PRKAG1, PRKAA2, BCAT1, EPHB4, EPHB1, GYS2, EMP2, EIF5, CSE1L, VCP, CASP9, CASP6, SEC13, NPEPPS, SH3BGR, EIF3B, BID, AP1S2, HDAC4, EIF6, PEX3, MAP3K7CL, GEMIN4, PCBP4, NUP107, SNX16, SESN2, MTPN, TIRAP, NLRP5, ARPC4, SEC61G, TPI1, PTEN, GABARAPL2, MYL6, ACTB, RAC3, EIF4A1, RPS20, SNAP25, PRPS1, CDC42, SRP54, UBE2D3, UBE2M, ACTR3, ACTR2, RAP2B, RPS3A, RPL26, PSME3, RPL15, RPL27, RPL37A, RHOA, NCALD, SEC61A1, STXBP1, COPZ1, RPL37, AP1S1, NUTF2, RPS7, PPP1CA, PPP1CB, CALM2, NCS1, PSMC1, RPS8, RPS15A, RPS16, YWHAE, RPS14, RPS18, RPS13, RPS11, SNRPF, LSM3, LSM6, SNRPD1, SNRPD2, SNRPD3, PSMC6, RPL7A, RAB11A, PPP2CB, ACTA2, RHOB, RPL23A, RPS6, RAB1A, RAP1A, RPS25, RPS26, GNB1, POLR2L, RBX1, GNB2, RPL30, RPL31, RPL10A, RPL32, RPL11, PPIA, RPL41, RPS27A, UBA52, GRB2, RAC1, AP2B1, VAMP2, YWHAZ, DYNLL1, RPL38, SKP1, RPS21, EIF5A, RACK1, ACTG1, ACTG2, UBE2I, TPM4, ACTC1, EEF1A1, TUBA4A, TUBB4B, PAFAH1B2, HBB, HBG1, HBA1, IGBP1, PIP4K2B, CCT2, CCNA1, GSTO1, PRKDC, BLOC1S1, BTG2, CRADD, NUCB2, TMF1, RPL24, RPL36A, SMAD3, ARF1, RPL19, SERF2, GNAS, SHC2, XIAP, FOXO4, CYCS, TFAM, CDK6, CDK5, HSF1, SORD, MYBPC1, IRF9, MDM2, PLIN5, SPTBN1, SET, RELB, AMPD3, MYL7, FABP5, ANK2, HMGCS1, SLC7A5, POU5F1, OCRL, MYL5, CENPE, KIF23, ID2, APBA1, RPL18A, MAP2K1, FKBP4, DST, GSTM4, CENPC, MVK, RELA, GBE1, TLE1, PRKCQ, GLO1, AKR1C1, REL, YWHAH, ICA1, PTK2, LIPE, ZBTB16, PRKCD, CALD1, RNASEL, PTPN11, PPAT, GFPT1, EXOSC9, AOX1, SULT2A1, PRDX1, RPL18, C1QBP, TJP1, ZFP36L1, KHDRBS1, BAX, MCL1, SOS1, SOS2, PPP3CA, CRYZ, PDE4C, PDE4D, DMPK, NCBP1, KCNA1, AHNAK, HSPA14, AP1B1, NUP160, SREBF2, FOXO1, AKAP13, CDC20, STX4, DPYD, HYAL2, TRIM26, ANK3, DLG1, RALGDS, ABR, TIAM1, ARHGAP5, STK4, TRAF1, CHAF1B, MTAP, EIF2B5, FADD, PRDX4, MAP2K5, MAPK7, PAK2, CBLB, PSMD2, DNAJC3, SELENBP1, MAD2L1, G3BP1, SKP2, GRB10, ITGB3BP, PPP2R5C, PDE3B, PDCL, UBE2V1, DYNC1I2, ORC1, ILK, XRCC4, UNC119, GOLGA4, MYO9B, NFATC2, GAB1, SMAD4, BIRC3, MTM1, SQSTM1, EIF4EBP1, RIPK1, HDAC1, CAMK2D, DCTN2, NAE1, ITPK1, IQGAP2, SNX1, MTMR1, MTMR2, CUL2, CUL3, CUL4B, FHL1, PMAIP1, BLMH, EXOSC2, RAPGEF1, IDI1, PDE7A, CUX1, CKAP5, HNRNPD, IL18, DAG1, EIF3A, ARHGEF7, DPYSL3, DCTN1, DYNC1H1, EIF2B1, EIF4A2, TRIM25, FLNC, GALE, PDE3A, CAPRIN1, GRB14, SLBP, NBR1, RASA3, KCNJ11, PUM1, ESPL1, SMC1A, RRP1B, LPIN1, PPP2R5D, COG2, CASP8, KIF22, NFATC4, KPNB1, PSME4, CUL7, ARHGAP19, NCAPH, NCAPD2, EXOSC7, ARL6IP1, KARS, KIF14, EEA1, NCF4, PAFAH1B3, PEA15, PRKD1, PCM1, PPP2R5B, PTGES3, QPRT, RASA2, RNPS1, ERBB4, RALBP1, ANKRD1, RPS6KA2, TCEB1, TCEB2, RHEB, DHCR24, RPS6KA1, SEC23A, SHB, STIL, RGN, TESK1, DIXDC1, TRADD, TSN, TRIP10, MAPRE1, ELAVL1, MYLK, TAB1, SMAD2, SMAD1, ITSN1, STK11, STXBP2, VAMP3, NEDD8, HSPB2, SEPT7, UAP1, PKN1, PKN2, MAPK14, CDC37, DPYSL2, FXN, NTRK2, FSCN1, HIF1A, IFI16, KYNU, GUK1, HAGH, DUSP6, DUSP7, UPP1, UGP2, DGUOK, ATP6V1F, PFKFB3, PFKFB4, CDO1, TXNRD1, LONRF1, PDS5A, ARHGAP31, ERCC6L, TSR1, HKDC1, LRRFIP1, TKFC, CCDC88A, COX19, PREPL, AMOT, MIDN, ARHGAP29, PDCD4, C11orf73, KLHL12, PYCRL, CDCA8, SGOL2, PAN3, ODF2, PDZD11, CMPK2, SGOL1, HERC4, WDR44, DOCK11, CEP78, HABP4, GNAS, WIPI1, EXOSC6, LDLRAP1, THEM4, BCL2L15, HECTD2, ARHGEF16, DENND4C, LRRC16A, FBXO31, CEP135, WWC2, XAF1, NADSYN1, JADE1, DENND5A, JMJD6, PTRF, ARHGAP11A, PPIP5K1, PSRC1, BORA, SHQ1, PAPD4, CPLX2, BLOC1S3, RICTOR, SARM1, AFTPH, RANBP10, DSTYK, RNF19B, PHLPP2, SYDE1, VPS13C, USP34, CENPU, TUBA1A, RHOU, ASRGL1, CENPQ, CYFIP1, RASGRP2, MON2, RNF144B, NPHP3, HAUS6, ARHGAP22, WAPL, NET1, SPRED1, SRGAP1, RBBP6, ARHGAP30, FGD2, RABEPK, PNPLA5, HUWE1, SDCCAG8, TTC7B, NOXA1, NT5DC3, AACS, ALYREF, IQGAP3, TAX1BP1, HOOK3, OSTM1, PKHD1L1, NLRC5, TRIM69, CARM1, CEP57, GPSM1, MIB1, DCP2, MINA, SIAH1, TRAPPC5, TPH2, UBR1, BBS7, WWC1, TP53INP2, SIRT2, MSRB3, FAM126B, AMOTL1, SRRM1, TRIM22, XRN1, ABI1, CENPL, TAGAP, ADSSL1, AHI1, CA13, ARHGEF28, ARHGAP24, APITD1, ARHGAP18, SFRP1, MINK1, TAB3, ARFGAP2, ENAH, HSD17B11, SPC24, SMG8, TNRC6A, ABCF1, PIK3C3, TRPV1, ATP6V1C2, DOCK8, NUP43, NUP37, ENGASE, BBS1, NUDT10, CMAS, CASC5, CEP70, KIF18A, TTC8, OSR1, GSDMB, TBC1D16, NT5C, DYNC2LI1, RHPN1, NEK9, TRPM4, RB1CC1, GEMIN5, FBF1, RAPGEF6, PARD3, ABHD5, PDCD6IP, FBLIM1, CHAC2, DEPDC1B, PHLDA1, BLNK, SNX33, SKA2, DNAJA4, GLMP, CYGB, ARAP3, EDARADD, GEMIN6, MYLIP, AHCTF1, RSPH1, TTN, ARAP2, RFFL, RAPGEF4, STARD8, GBF1, ELMO1, NDRG1, HSPH1, DOCK2, TBC1D5, NSMAF, AKAP1, TFG, USP6NL, HTRA1, STAM, GOLGA1, GGH, INPP5D, BCL2L2, TANK, KIFAP3, UFD1L, BAD, KHSRP, ARHGEF2, CUL5, TNFRSF25, HGD, RFK, ITFG2, PPP1R14A, TP53INP1, RERG, EXOC4, PNPLA2, PBXIP1, MIB2, EXOSC8, SKA1, SGK3, UPRT, MOAP1, HAUS1, OPTN, AP2M1, TUBGCP3, ANAPC16, SPDL1, HOOK2, SEH1L, MOCOS, MVB12A, CYFIP2, EDC3, PELI1, CDCA5, S100A16, DPH3, BICD1, PGM2, NUDT11, AURKB, CENPN, PDLIM5, DOCK6, SCLY, AJUBA, ZBED3, ABHD14B, NSL1, ITCH, SEC16B, DNAJC1, EXOC2, MARK4, PRMT6, CARD19, FGD4, PACRG, AK8, AGBL1, KCTD7, PRICKLE1, ANKRD27, ARAP1, IPO9, INPP4A, NEDD4L, SYNGAP1, FMNL2, SMG1, ALS2, GSDMA, DLC1, RAB3IP, VPS35, MCCC1, TRIB3, TP53RK, RANBP9, CEP89, NMNAT3, FAM129B, SEC62, STAC, PLIN2, NUP88, PIK3R4, TSC22D3, S100A13, DNAJC7, CDCA3, PKMYT1, CHP1, KIF2C, MAP3K5, MGLL, DOK1, MTR, SMAD5, CDC6, NPAS2, EPAS1, CCT7, HAUS7, PRMT1, DUSP9, SH3GL2, CITED1, VRK1, NCAPG, MAPKAP1, FERMT1, CORO1B, AIFM2, CENPK, INPP5K, POLR3GL, DCTN5, CENPO, DOHH, MKNK1, POLR3C, PDCD10, BDH2, CHAC1, ADI1, RNF126, MLST8, TRIM62, PHF20, DUSP23, NUP85, CDK19, SORBS1, BBS2, NPL, PINK1, IDI2, PACSIN1, HDAC8, POLDIP3, DUSP16, PARD6B, TRIM34, WNK3, PANK2, NUF2, ASPSCR1, OSBPL6, DPH1, TRIM8, UCK2, TRIM6, STRADB, NDEL1, MAP1LC3B, EIF5A2, UBA5, PAIP1, TOLLIP, RACGAP1, WWP1, AP5M1, GABARAPL1, ATG10, RBM38, ANAPC1, POLR3F, UPF3A, CDT1, SPTBN4, ALDH8A1, TNKS2, DPH5, DHX36, TXNIP, MUC13, CENPH, TPK1, DSN1, CHMP4B, MAP1LC3A, WNK1, RHOJ, EPB41L1, RGCC, GSTO2, HAUS4, EGLN3, DCTPP1, SYNC, PLEKHG2, PHAX, MOB1A, AKTIP, ECT2, ZWILCH, PSTPIP2, SEC61A2, LIN28A, UCK1, PELI2, PLEKHA5, SMURF2, UPF2, SCPEP1, RRAGC, AS3MT, SPC25, ETNK1, APOBEC3G, CENPJ, CAPN10, NEK6, MCCC2, TNRC6C, AGO4, TRIM39, SEPSECS, MYO10, PDE7B, ARFGAP3, VTA1, MID1IP1, PARD6A, EXOSC4, ISYNA1, MKKS, ACOT13, PLCB1, CYLD, RRAGD, PFDN4, EXOSC3, KIF13B, ACSS2, EIF2B3, ARHGEF4, ARHGEF3, PDGFC, EIF4ENIF1, SH2B1, CTPS2, PRTFDC1, LATS2, AASDHPPT, UBQLN4, INPP5E, SNX15, RAB6B, PHPT1, KIF15, HOMER3, SAMSN1, CENPM, DIAPH3, NRBP2, PDS5B, SMC4, ECHDC1, RNF146, ABHD10, TXLNG, NUDT15, RNF19A, EXOC1, PARVA, FGFR1OP2, RLIM, HAUS2, POLR3B, RNF216, UCKL1, GEMIN8, DDIT4, MKS1, PGPEP1, NDE1, SPHK1, MTMR4, ABI2, DACT1, FAM13B, BET1L, PLK2, GTSE1, ERAP1, FMN2, GLTP, IL37, RGL1, MAT2B, EHD3, AKAP7, ARHGAP23, ARHGAP20, CC2D2A, TBC1D14, ANKFY1, ATXN10, NFKBIL1, SAE1, NLK, PI4KB, HDAC6, VPS29, EIF3K, GRHPR, CTNNAL1, NXF1, ZMYM2, TJP2, DNAJB4, VTI1B, ADD3, PRKAG3, SEC63, KLHL3, TBK1, DDX20, BAIAP2L1, EVL, EIF2B4, ATP6V1H, LCMT1, SCOC, LNPEP, CNOT7, ERRFI1, CDC23, ANAPC5, ANAPC4, LSM7, CDC42EP3, NXT1, NUDT5, PCTP, FBXO5, AGO2, VAV3, MYH2, BAG5, BLOC1S6, MKLN1, WWC3, KIDINS220, ASAP1, CNOT6, NDRG4, TPX2, NOB1, PYCARD, PADI4, FZR1, ANAPC10, MYO6, NFU1, SUFU, NDRG2, G3BP2, ARHGAP26, STUB1, SNX6, ANGEL1, FAF1, NSFL1C, PLA2G4C, B9D1, PPP6R1, TNRC6B, SMG5, EXOC7, AGTPBP1, DICER1, SMC3, MAPK8IP1, SH2B3, GNE, POMP, CHKB, FARSA, BTRC, BTBD3, NISCH, PIKFYVE, DIS3, HIF3A, POLR1D, CRYL1, CARHSP1, GIT1, POLR3K, SUGT1, DERA, LSM2, CAB39, TPRKB, HDGFRP3, STARD13, RABGAP1, RPL36, C2CD2, WDR45, TLN1, KIF3A, DAAM1, FARP1, IRS2, MYO5A, WIPI2, ARIH1, LSM5, LSM4, RNF114, CEP83, YTHDF2, PAXBP1, UCHL5, ATP6V1D, N6AMT1, TRAPPC1, RBM8A, SNX5, PSAT1, COPG1, SAR1B, ARFGEF2, MAD1L1, STK24, SNCAIP, IGF2BP2, SESN1, WASF2

GO:0005832

CC

chaperonin-containing T-complex

A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.

TCP1, CCT6A, CCT3, CCT8, CCT2, CCT7

GO:0005833

CC

hemoglobin complex

An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.

CYB5R3, HBB, HBG1, HBA1

GO:0005834

CC

heterotrimeric G-protein complex

Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein.

GNG7, GNAI2, GNAI3, RGS7, GNG4, GNG11, GNB1, GNAI1, GNG5, GNA12

GO:0005838

CC

proteasome regulatory particle

A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.

PSMD12, PSMD10, PSMD7, PSMD2

GO:0005839

CC

proteasome core complex

A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex.

PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, PSMB10, PSMB3

GO:0005840

CC

ribosome

An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.

PRMT3, EIF2S1, RPS17, MT3, CANX, SNCA, RPS27, RPS9, RPS10, RPL15, RPL27, RPS7, RPS18, RPS13, RPS11, RPS25, UBA52, MRPS25, MRPS10, MRPS34, RPL36A, HSPA14, DNAJC21, MRPL54, MRPL14, MRPL50, ABCF1, GCN1, MRPL38, METTL17, MRPL44, RRBP1

GO:0005844

CC

polysome

A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.

EIF2S1, RPS4Y1, EIF4B, PSMA1, CALR, FUS, FXR1, RPS6, FMR1, NAA30, GCN1, MSI2, UNK, EIF2AK4, IMPACT, AGO2, DRG1

GO:0005845

CC

mRNA cap binding complex

Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.

EIF4E2, EIF4E, FMR1, NCBP1, CYFIP1, AGO2

GO:0005846

CC

nuclear cap binding complex

A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.

NCBP1

GO:0005847

CC

mRNA cleavage and polyadenylation specificity factor complex

A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.

CSNK1A1, CPSF1, FIP1L1, ZC3H3, SSU72, CPSF2

GO:0005849

CC

mRNA cleavage factor complex

Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules.

NUDT21

GO:0005850

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eukaryotic translation initiation factor 2 complex

Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.

EIF2S1

GO:0005851

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eukaryotic translation initiation factor 2B complex

A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.

EIF2S1, EIF2B5, EIF2B1, EIF2B3, EIF2B4

GO:0005852

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eukaryotic translation initiation factor 3 complex

A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.

DDX3X, EIF3J, EIF3B, ABCE1, EIF3A, EIF3K

GO:0005853

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eukaryotic translation elongation factor 1 complex

A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma.

EEF1B2, EEF1D, EEF1A1, EEF1A2

GO:0005856

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cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

FRMD3, PDLIM1, HIP1, SDCBP, TOR1A, ENC1, ITGB1BP1, RAB29, SYNJ2, NPHP1, TGFB1I1, RIPK2, SPRY2, PDE6D, LZTS3, PPL, MPZL2, SORBS3, JAK2, LDB3, HSBP1, ARL6IP5, FARP2, PNP, KRT1, HSPB1, S100A8, S100A9, TPM3, TUBB, PFN1, VIM, KRT16, TPM1, FGR, ALDOC, DMD, JUP, KITLG, JAK1, STOM, MAPK3, MAPK1, PTPN4, NOS3, NF2, ACTN2, LRPPRC, CAPZB, CCT3, HINT1, CNN1, JAK3, MAP2K6, ARHGDIA, ARHGDIB, CAPZA1, SMTN, GYS2, EPPK1, ACTB, RHOA, ACTG1, TPM4, TUBB4B, CDK5, ANK2, PTK2, CALD1, NEXN, MYO1E, CALCOCO2, SNTA1, SHROOM2, SNTB1, COTL1, DAG1, CTTN, FLNC, CASP8, FRMPD4, DHCR24, TRADD, TRIP10, TRIP11, TRIP6, CCDC6, SGCB, FSCN1, PTPN21, LRRFIP1, PREPL, WIPI1, TBCEL, FNBP1L, ARHGAP21, KAZN, TWF2, SLC30A9, DNMBP, FGD6, RAPH1, SSH2, MAEA, FGD2, NEK8, NOSTRIN, ABI1, ARHGAP24, ENAH, JMY, BICD2, SSH3, RNF128, PARD3, SHROOM3, ARAP3, TRIB2, DOCK2, SGCD, SYMPK, INPP5D, ARHGEF2, BICD1, TCTN2, SGCZ, FRMD6, KLHL5, RAB3IP, FNBP1, PKP4, DNAJC7, MARVELD1, OSBPL10, PINK1, UACA, TRIM9, KLHL4, ACTR6, EPB41L4B, DEF6, EPB41L1, PSTPIP2, TNS1, EPB41L4A, SPAG4, CASS4, GPHN, CDC42SE2, CDC42SE1, PARVA, ABI2, DNAH9, PLEK2, MARK1, CC2D2A, FRMD4A, UXT, CTNNAL1, ADD3, KLHL3, DDX20, EVL, DNAI1, TNIK, TAOK2, PLEKHH1, ARHGAP26, MACF1, SLC7A11, EPB41L3, FRMD4B, FARP1, FAM65B, CDC42BPB, IGF2BP2, PCLO

GO:0005858

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axonemal dynein complex

A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.

DNALI1, DYNC2LI1, DNAH1

GO:0005859

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muscle myosin complex

A filament of myosin found in a muscle cell of any type.

MYL6B, MYL9, MYH11, MYL5, TTN, MYH2, MYH4

GO:0005861

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troponin complex

A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.

TNNT1, TNNI3

GO:0005862

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muscle thin filament tropomyosin

A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments.

TPM3, TPM2, TPM1, TPM4

GO:0005865

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striated muscle thin filament

Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.

TMOD1, LMOD1

GO:0005868

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cytoplasmic dynein complex

Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.

DYNC1I1, DYNC1LI2, BCL2L11, SNX4, TPR, DYNLL1, DYNLT1, DYNC1I2, DYNC1H1

GO:0005869

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dynactin complex

A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.

DCTN6, ACTR1B, DCTN2, DCTN1

GO:0005871

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kinesin complex

Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.

KIF1C, KIF5C, KIF1B, KIF20A, KIF4A, KIF11, YWHAE, CENPE, KIF23, KIF22, KIF14, KLC3, KIF18B, KIF18A, KIF20B, KIF2C, KIFC1, NDEL1, KIF13B, NDE1, STARD9

GO:0005873

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plus-end kinesin complex

Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule.

LOH12CR1, KIF15

GO:0005874

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microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

EML1, KRIT1, DYNC1I1, MID1, BIRC5, DYNC1LI2, SYNJ1, SPRY2, ZNF207, KIF1C, KIF5C, KIF1B, TPPP, HAUS5, WDR47, KIF20A, PCNT, EML2, TTLL1, DNAL4, TUBB4A, TUBB, MAPT, MAP2, STMN1, TCP1, MT3, CLIP1, MAP2K2, CCT6A, LRPPRC, MAP1B, IQGAP1, CCT3, EMD, CCT8, NEK2, KIF11, DYNLL1, TUBA1B, TUBA4A, TUBB4B, IGBP1, CCT2, MAP1A, CENPE, KIF23, FKBP4, GOLGA2, CAMSAP2, DNAH14, DLG1, TIAM1, MTA1, DYNC1I2, SNTB2, TUBB3, DCTN2, TUBA3C, SHROOM2, TUBB2A, EIF3A, DCTN1, DYNC1H1, MAP7, KIF22, KIF14, MAPRE1, DPYSL2, CSPP1, FAM110C, TTLL9, ODF2, CEP170, CAMSAP1, REEP3, KLC3, SARM1, DNAH12, TUBA1A, HAUS6, HOOK3, RASSF3, GAS2L3, CEP57, LRRC49, DNAH10, CCDC50, SIRT2, NAV1, MDM1, NEK7, DNAH5, SHROOM3, RASSF5, NDRG1, HSPH1, APPBP2, FGF13, ARHGEF2, TEKT1, PBXIP1, HAUS1, RMDN1, DNAH11, HOOK2, RMDN2, KIF20B, FEZ1, CCT7, HAUS7, TBCD, TUBB6, KATNB1, TUBB2B, KIFC1, KATNAL1, NDEL1, MAP1LC3B, RACGAP1, GABARAPL1, MAP1LC3A, TUBB1, HAUS4, EML4, CENPJ, NEK6, MID1IP1, KIF13B, RASSF1, KIF15, TCP11L1, STAU2, SYBU, NDE1, DNAH9, CAMSAP3, DNAH1, HDAC6, SPAST, DNAI1, TEKT2, TUBE1, TUBD1, MTUS1, TPX2, MACF1, INVS, FAM179B

GO:0005875

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microtubule associated complex

Any multimeric complex connected to a microtubule.

EML1, MID1, KIF1B, STAU1, EML2, MAPT, MAP2, MAP1B, RANBP2, MAP1A, MAP7, PEA15, APPBP2, RANBP9, DNAAF2, HDAC6, CLIP2, RABGAP1

GO:0005876

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spindle microtubule

Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

AURKA, HDAC3, PRC1, TBL1X, NCOR1, KIF4A, CDK1, CDC27, CSNK1D, KIF11, PLK1, CALM2, PSRC1, SKA3, SKA2, KIFAP3, SKA1, AURKB, SPAG5, NUSAP1, TBL1XR1, HAUS2, KIF3A

GO:0005879

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axonemal microtubule

A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.

ARFGEF2

GO:0005881

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cytoplasmic microtubule

Any microtubule in the cytoplasm of a cell.

AXIN1, MID1, BCL10, SAA1, CYP2A6, TUBG1, APC, CLIP1, DYNLT1, TUBA1B, MAPRE1, TUBA1A, DCXR, HID1, DYNC2LI1, CKAP2, BICD1, GRAMD3, KIF2C, VIMP, ENKD1, TRPV4, CYLD, GTSE1, HDAC6, CLIP2, SRPRB

GO:0005882

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intermediate filament

A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.

KRT18, KRT8, VIM, KRT19, KRT7, KRT16, KRT3, JUP, NME1, DSP, GJA1, DES, NME2, CLIP1, KRT9, SLC1A4, NES, DST, KRT17, IFFO1, MNS1, MICAL1, PKP2, KRT23, PNN, SYNC, MYO5A

GO:0005883

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neurofilament

A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter.

NRP1, NEFH, LDLRAP1

GO:0005884

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actin filament

A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.

WIPF3, ARHGAP6, DAPK3, WDR1, COBL, FYN, ACTN1, LCP1, RAC2, EZR, RHOQ, TMOD1, LMOD1, CORO1A, ACTN2, IQGAP1, CAPZB, RAC1, ACTC1, TEK, AKAP13, MYO9B, CTTN, PLS1, AMOT, PALLD, PAWR, AIF1L, CORO1B, MYO5A

GO:0005885

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Arp2/3 protein complex

A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.

ARPC2, ARPC3, ARPC4, ACTR3, ACTR2

GO:0005886

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plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TBC1D3D, TBC1D3E, KIAA0922, TBC1D3F, MYO1G, MYO1C, SNAP23, FXYD1, AIP, KCNK1, TLR4, RHOD, APBB1, GRM8, CLIC1, TNFRSF11B, PIK3CD, WASL, PIK3C2A, BTN3A3, KRIT1, CHL1, SDCBP, CLDN4, PLPP1, PLPP3, ARHGAP33, KCNK3, IRS4, ADAM10, ITGB1BP1, NRP1, TNFSF11, TNFRSF10C, TSPAN4, TAX1BP3, PCDH17, RGS12, CASK, RAB29, SYNJ2, SMAD7, FYB, ANGPT2, PLSCR1, ZNF185, SLC22A1, FANCG, OGT, GRM6, GPR37, HDAC3, NCAM2, STX7, SLC16A3, SLC31A1, ABCC4, ABCC5, RGS5, ASAP2, FLRT2, ADAM12, IRAK2, SPINT2, AQP9, MAP3K7, DHH, RASA4, MGAM, CACNA1G, ATP8B1, CA12, AKAP10, SPRY2, SPRY1, PRC1, RGS10, ITM2A, CYTH3, STX6, SSNA1, C21orf2, TYROBP, PPP1R12B, GNG7, ADCY3, TRAK2, FZD6, PPL, NRP2, PLXNC1, ADCY9, NMT2, TLR5, TLR2, SLC16A7, LPXN, CTNND1, SLC19A2, RAMP1, RAMP3, FCGR3B, PLXNA2, SDC3, ADAM23, FZD7, AOC2, ATP9A, ROCK2, MFAP3L, COBL, PHACTR2, LRP5, SEMA7A, HMMR, ATP6V1G1, ENTPD6, ENTPD3, FLNB, TULP3, GPR32, TECTA, LGR5, GPC4, TNFRSF21, STX11, SKAP2, CRCP, ITGA10, LRP6, ADAP1, RP2, SLC22A3, GABBR2, PAK3, ARL6IP5, FLOT1, SLC22A5, BEST1, SRP72, DXO, STK17B, AQP8, SLIT2, PLEKHG5, LRIG2, ERLIN2, DKK1, ABCA8, SLCO2B1, AP2A2, UNC5C, SNX4, ABCA1, VNN1, SLC2A10, STAMBP, DIRAS3, SNAP29, STAU1, RECK, BCL10, DNAL4, ACTL6A, F8, GOT2, EGFR, AK1, F2, PLG, PLAU, CFB, ADA, CA2, SERPINC1, C3, KNG1, NRAS, KRAS, LDLR, TGFA, TGFB1, PENK, GCG, IGF2, TNF, CD4, HLA-B, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, APOA1, APOE, FGA, FGB, FGG, GYPA, AMBP, TFRC, ESR1, RAF1, ANXA1, APOB, PRNP, CD74, KRT1, GAPDH, ERBB2, NTRK1, HSPB1, CYBB, GNAI2, SLC4A2, GYPC, IGF1, ATP1B1, APP, ITGB3, ITGB2, S100A8, SERPINE1, ALPL, ICAM1, ITGB1, PRKCB, INSR, FYN, S100A9, ENO1, GPI, ITGAV, LPL, CSF1R, ANXA2, ADRB2, HSP90AA1, LYN, IGF1R, NGFR, CHRM2, CD55, SLC3A2, MMP2, MME, CD14, PTPRC, MET, ADRB1, ITGA5, VIM, KRT19, GNAI3, STS, RPSA, IL6R, ENO2, GSTP1, CD48, HMGB1, CLTA, ANXA4, CNP, WNT2, PDGFRB, FGR, LCT, UCHL1, FURIN, C4A, C4B, TBC1D3H, UBC, RAP2A, AR, RRAS, PTPRF, MAPT, TFPI, KIT, CD28, HSPD1, GHR, HSPA5, SLC2A1, SLC2A3, ITGAM, RALA, RALB, LAMP1, FGFR1, PSKH1, F5, FCGR1A, FCGR2A, ANXA3, ACTN1, ACE, XRCC5, IFITM1, GP1BB, TDGF1, LAMP2, CFTR, NCAM1, EEF2, HLA-E, HLA-DRB4, LCP1, PRKAR2A, ENO3, ADRB3, SELL, CD99, CPM, DRD2, PLA2G2A, PKM, HSP90B1, SLC2A4, IDE, IL1R1, JUP, ETS2, PVR, RAC2, IFNGR1, B4GALT1, ACPP, EZR, FOLR1, VAV1, CD46, CD1D, DSP, ALOX15, CD44, ITGB4, PDGFRA, PECAM1, EPCAM, PRLR, GNB3, SELE, CD36, CPE, IL7R, PLCG2, RHOQ, IFNAR1, PRKCA, ITGA2, GJA1, NPR3, GAP43, HLA-G, PTPN2, CR1, LGALS3, ITGB5, ADRA2B, IL1RN, SDC1, PAM, CDH2, CD58, VCAM1, CD53, ATP2B1, HLA-DPA1, CD33, CHRM3, TNFRSF1B, RAB3B, RAB5A, TRH, NPR2, ITGAX, CAPN3, EFNA1, MAG, ATP6V1B2, ATP6V1C1, FLNA, S1PR1, FPR1, CNR1, SYT1, KITLG, NT5E, C5AR1, ZP3, FGFR2, ERBB3, SDHB, CD9, COMT, ENPP1, SLC2A5, CA4, LHCGR, MRC1, ITGA6, ANOS1, PTPRD, TNFSF4, ATP2B4, FSHR, CXCR2, APC, FPR2, ADRA1D, EDNRA, PTAFR, F2R, AZGP1, FAS, MT3, NPY1R, ITGA3, ITGB8, KLRC1, CD27, ACVR2A, DPP4, IL1R2, PIK3R1, SSFA2, HTR2C, ADORA2B, CTGF, EPHA3, EPHB2, LTK, NOS3, CD40LG, MARCKS, CNGA1, GNA11, BLVRB, CCND3, MIP, HLA-A, HLA-F, AVPR2, ADSS, SLC6A1, CHRNA5, LRPAP1, ADORA1, AGTR1, OXTR, SSTR1, GNRHR, CORO1A, PRKAR2B, SDC4, SLC6A6, GABRA5, AKT1, AKT2, FCGR2B, CCKBR, MC4R, GPR183, GBP1, STX2, ACSL1, CDH5, LSP1, ABCC1, SDC2, CD68, GRK5, HTR7, GPC1, BTC, USP6, CTNNA1, CTNNB1, PHB, NF2, RDX, SSTR5, ADRA1A, HRH1, ADRA1B, PTGER4, IRS1, MYH9, ACTN2, BSG, ADRBK2, FLT4, GJC1, CHRNA7, NUDT1, BMPR1A, ACVR1B, TGFBR1, LTBR, SCNN1A, TGFBR2, SNCA, BRCA1, IFNGR2, SPAM1, ITGAE, FEN1, PLA2G5, IL6ST, STAT3, MDH2, PMEL, OPRL1, ETV5, AQP2, CD200, RGS2, WNT5A, CSK, SLC19A1, ADCYAP1R1, HTR2B, PRKCI, PIK3CA, PIK3CB, EPS15, DPP6, IL12RB1, LIFR, SLC1A3, SLC1A2, SLC1A4, GDF5, PTGFR, PTGER3, PTGER2, MCAM, GRK6, SYK, KIR3DL2, PHKA2, PHKA1, NSF, NOTCH1, MAP1B, IQGAP1, OR3A3, SLC6A8, MTNR1A, ATP5O, GRIA4, LIMS1, GLIPR1, NPBWR1, GLRB, LEPR, CD151, IFNAR2, SLC1A6, CSNK1D, PIK3CG, CD97, TRPC1, NPY2R, PTH2R, SLC11A1, SLC11A2, MTNR1B, FASN, CCT3, PCYT1A, ARL4D, TMED10, NUMB, PSEN1, HINT1, RGS3, RGS4, RGS7, PSEN2, GSK3B, SEPHS1, AGTR2, GNAQ, GNG4, MMP14, SLC26A2, METAP2, KNTC1, LRBA, RNF144A, BCAM, ATP1A2, RAB5C, RAB9A, RAB28, SCNN1G, PLCD1, MMP15, MMP16, IRAK1, CAV2, CLCN3, CLCNKA, CLCNKB, PLXNA3, VAMP7, ADCY7, SLC7A2, STAT2, MSH6, EFNA4, EFNB2, EFNA5, DAPK1, SUCLG1, RABGGTB, AP2S1, CACNB3, CACNA2D1, ATP12A, ATP1B3, EPHA5, EPHB4, EPHB1, EPHA4, GAS1, EMP1, EMP2, EMP3, EIF5, SLC12A2, RRAD, MFAP3, F2RL1, CDH6, CDH11, CDH12, CDH13, CDH15, NPEPPS, TMEM50B, WNT3, PRSS12, HSD17B7, JAM2, ANTXR2, TIRAP, FXYD4, CD81, PLP1, PTEN, PPP4C, ACTB, RAC3, ZP1, SNAP25, CDC42, RAB4B, RAB5B, CXCR4, UBE2D3, RAP2B, RHOA, STXBP1, B2M, GNG11, RRAS2, TSPAN5, PPP1CA, CALM2, NCS1, RAB11A, RHOB, RAP1A, GNB1, GNB2, RPS27A, UBA52, GRB2, RAC1, AP2B1, VAMP2, GNAI1, UBE2B, DYNLL1, GNG5, ACTG1, PAFAH1B2, CXADR, SIRPA, ADAM8, DLG4, PIP4K2B, OLR1, BTN3A2, JAG1, ADAM17, HLA-DRB3, NUCB2, SLC7A9, SMAD3, ARF1, ARF5, GNAS, SHC2, DAB2, VLDLR, HSPG2, PKD1, LRP2, HDLBP, CDK5, CDK16, MDM2, CD83, IL5RA, PMP22, ANK2, HMGCS1, IFITM3, IL1RL1, SLC7A5, MC2R, XPC, EWSR1, OCRL, ROR1, SP3, DSC2, MAP2K1, TEK, GNA12, CAV1, PLAUR, NOTCH2, PRKCQ, CD164, YWHAH, PTK2, ZBTB16, PRKCD, CALD1, SLC18A2, APLP2, C1QBP, TJP1, POLE, SOS1, TNK2, PCDH1, IL10RB, DDR1, SLC20A2, CD47, DMPK, KCNA1, AHNAK, FCHO2, SMAGP, APOBR, BST2, ARHGEF5, KCNMA1, ASPH, KCNH2, RAB40B, STX4, CNTN1, CDH17, MERTK, GRIN2A, HYAL2, PTPRJ, ANK3, DLG1, PTP4A2, ABR, TIAM1, MALL, STRN3, BAMBI, FADD, PAK2, CBLB, PTGDR, STX3, G3BP1, CLN3, GRB10, IFIT5, SLC14A1, PPIL2, ORC1, ILK, SLC39A6, LSAMP, NFATC2, IL18R1, TCIRG1, GPM6B, MTM1, TRPC3, SERINC3, CAMK2D, PKD2, NAE1, TDG, DGKZ, SEMA5A, MTMR1, PTCH1, FHL1, ACVR2B, SHROOM2, ITGA9, ENPP2, BMPR2, KLF9, CACNA1C, CEACAM7, KCNC3, RAB33A, DAG1, DSG2, ARHGEF7, SCARF1, EIF2B1, SELPLG, CTTN, FLNC, GPR176, GRB14, KCNJ12, FAT1, ITPR2, ITPR3, INPP5A, ITPR1, KCNJ11, KANK1, MELK, RFTN1, GRM3, GPNMB, CLCA4, MORF4L2, JOSD1, SLC39A14, KARS, KIF14, ACOX1, PDIA6, PLCL1, PRKD1, NECTIN1, ERBB4, ANGPT1, MTFR1, P2RY14, TLR1, SHB, TGFBI, TRADD, TRIP6, SLC1A5, NPY5R, MSMO1, ITSN1, STXBP2, VAMP3, CACNA1E, RAB11B, ZYX, SEPT7, ADRM1, UAP1, SLC15A2, PKN1, PKN2, ASIC2, OCLN, DBN1, PTPRO, CYP51A1, AOC3, DUOXA1, MICB, MICA, PDS5A, ERCC6L, RALGAPA2, SLC4A8, HLA-DRB5, HFE, LRRFIP1, CHD9, PIGY, CCDC88A, ANO6, NKAIN1, ATP13A5, RFTN2, CYBRD1, SDK2, TMEM97, IGSF11, BCORL1, ALG10B, RALGPS1, TJAP1, GNAS, DGKK, COLEC12, MUC21, FNBP1L, THEM4, ABCC10, STXBP5, GPR158, WLS, COL13A1, ANKRD20A1, CROCC, GPR157, RIF1, NKAIN2, CHIC1, DENND4C, LRRC16A, ZDHHC20, TNS2, TMEM198, STEAP4, LAIR1, LAMTOR1, JADE1, OR52E8, TBC1D3C, STYK1, RGS7BP, TENM4, MFSD5, RGMB, JMJD6, MAST2, ERAP2, SLC27A4, SLC39A4, LRRC8B, SLC27A1, PPIP5K1, TMEM65, CNST, ADGRD1, AGTRAP, ANKRD11, PARM1, C6orf89, OLFM4, SEZ6L2, LRIG3, GLDN, BNC2, SLCO4C1, QSOX2, RAPH1, PREX2, SV2A, RHOU, SV2B, RAB11FIP2, ARC, RASGRP2, SLC16A14, SLC16A9, PLPPR4, SLC36A1, DCXR, SDK1, NET1, SPRED1, RABEPK, PXK, PHLDB2, GPR126, ZBTB33, TTC7B, MAGI2, SLC51A, CD163, SERINC5, P2RY8, SGMS1, SLC26A11, RASSF3, CHD1L, TRIM69, RALGPS2, LSR, DGKH, TMEM219, FRAS1, COL23A1, PDPN, GPSM1, C2CD5, MIB1, TMPRSS6, CRLF3, SIAH1, RELL1, PLEKHH2, NOSTRIN, VSTM4, SERPINA12, SLC44A2, ITPRIP, LRRC8A, SLC30A8, SULF2, SULF1, CNTN4, SIRT2, KLHL7, PALM2, FAM126B, TMEFF1, ANKRD13A, KIAA0319L, KMT2E, XRN1, UNC5B, CPAMD8, TBC1D3, NLGN4X, SPG20, GPC2, CRIPAK, ARHGEF28, LYPD1, ABHD12, NLGN1, MUC15, MPP5, SFRP1, SLC44A3, ARHGEF39, AFAP1L2, TAB3, ARRDC1, ARFGAP2, AOPEP, CD177, NIPA2, ENAH, MFSD2A, PCSK9, SERBP1, DAGLB, SLC44A5, ARRDC4, LRRC16B, RGS22, BVES, PLPP5, TRPV1, FLCN, NUP35, GPRC5A, DNER, STXBP6, SEMA6D, TSPAN14, OR5A2, OR5L2, OR14C36, SVIP, LILRB1, SGMS2, TPCN2, INADL, PCDH19, KCNG3, CYP2W1, GSDMB, SPATA20, SLC35G2, ENOX1, KIAA1524, MARCH1, SPPL3, SPPL2A, HM13, MRAP, BICD2, TRPM4, DLG5, KCNV2, LRRC8C, SYTL5, FAT3, IGDCC4, RAPGEF6, PARD3, PAQR8, SH3TC2, ATP8B4, SLC16A10, SCARB1, FRS2, RAB2B, CEMIP, SLC20A1, SLC38A5, BLNK, SECTM1, APH1B, SLC44A1, ARAP3, IPCEF1, STAB2, SLC5A11, LIPH, PALLD, GPR98, CLEC4D, CACNG8, DNAJC9, MYLIP, RFFL, RAPGEF4, CLEC2B, AQP3, PIEZO1, SLC7A6, ELMO1, SLC9A6, NDRG1, SGCD, FCGR1B, RYR2, USP6NL, HTRA1, SYMPK, DIO2, NRCAM, INPP5D, GHSR, GLG1, SLC5A5, FGF13, RAB8B, SLCO2A1, RIT1, TNFRSF25, ATP6V0A1, LPP, MR1, KISS1R, PMEPA1, ADIPOR1, EXOC4, PNPLA2, TTC17, ARRDC3, SLC22A18, APH1A, SYTL4, GPR146, TLCD1, AP2M1, RASD2, REPS1, RAB39B, C11orf24, CDCA5, SLC47A1, CPNE2, S100A16, PERP, MRAP2, VMP1, SLC41A3, AJUBA, PAWR, ITCH, SLC41A2, DNAJC1, FAM84B, EXOC2, FCRL1, APOLD1, KCTD7, FRMD6, C8orf37, PTCHD1, SLC46A1, ANKRD27, CLIC6, ARAP1, ERMAP, NEDD4L, PLIN4, GSDMA, TRPM7, MAGI1, OR2A5, PANX2, PANX1, FNBP1, TRIB3, RANBP9, RASL10B, MYADM, SRPK1, CEP89, KCNK17, FAM129B, CSF3R, HBEGF, S1PR3, NEU1, GPER1, PLIN2, MPHOSPH8, MPHOSPH9, PKP4, P2RX4, OSMR, CHP1, MGLL, FEZ1, HSD17B10, LITAF, MGST2, SLC29A1, CIB1, HAUS7, PRRT1, PKP2, SH3GL2, MAPKAP1, VIMP, TMEM47, HEPH, CORO1B, CPPED1, SDF4, ESYT1, MARVELD1, INPP5K, UPK3B, SYT11, NDC1, PDCD10, ABHD6, ADI1, KATNB1, TAPBPL, SORBS1, JAM3, TRPM6, LGR4, CLEC7A, TMEM59, CACNG6, SLC46A2, PACSIN1, HDAC8, CADM1, PARD6B, NLN, PCDH11Y, ASPSCR1, OSBPL6, GPR63, PRKD2, ULBP3, FAM129A, CD244, SIGLEC1, TRIM4, INO80B, SLC39A8, WWP1, CCDC8, SDCBP2, CYSTM1, TRPV6, UPF3A, WNT5B, ABCG8, EHD4, SPTBN4, OR51E2, CXCL16, SLC26A1, TSPYL2, SLC38A1, TAOK3, RAB3GAP2, PNN, RHBG, TTYH1, SEMA4A, PIGU, RHOJ, DEF6, EPB41L1, FNDC4, GAREM1, DOCK5, C10orf54, AKTIP, HN1L, LIN7B, SLC28A3, SMURF2, PLEKHA2, NTN4, TRPV4, IFT122, VEZT, ETNK1, LGR6, PCDH9, SLC24A3, CAPN10, GBA2, SYTL2, MAGEE1, ANKH, PCDH18, GPAM, TMEM8A, SRA1, GOPC, RANGRF, MYO10, CD209, ABCB6, SLC40A1, TNFRSF12A, TREM1, MMP25, PARD6A, ACKR4, NRN1, CD320, ADAP2, IL1RAP, CD93, SLC52A3, ANO2, RTN4, NECTIN3, GPHN, CD163L1, DLL4, PDGFC, DUOX2, DUOX1, IL17RB, PLSCR4, CDC42SE2, INPP5E, CDC42SE1, SERINC1, AGPAT3, RASSF1, KCNIP2, GPR27, TNFRSF19, TM7SF3, HOMER3, LMBRD1, LIN7C, TDP1, EXOC1, PARVA, PAG1, PAK1IP1, PAQR5, STAB1, VNN3, SPHK1, CELSR3, ERAP1, FMN2, FAM120A, GDE1, GPRC5B, FLRT3, FLRT1, CRIM1, MPP6, VAPA, MARK1, CNTN3, STIM2, FNIP2, PCDH10, ATXN10, CTSZ, GABBR1, CTNNAL1, SLC9A2, TJP2, DNAJB4, KL, ADD3, EPHA6, SLC23A2, TES, SLC2A6, LIMA1, ASIC3, PCYOX1, SLC7A8, BAIAP2L1, ATP6V1H, SLCO3A1, ZDHHC2, LNPEP, PLXNA1, KCNG1, GPR160, CDH22, ENPP5, LAMP5, CDC42EP3, ADAM21, ACSL6, VAV3, ITGA11, PRND, RAB22A, NRXN1, RAB23, MTUS1, FZD4, SLC7A7, MYO6, COL17A1, PCDHGC3, PCDHA12, SLC6A14, RPH3AL, STUB1, PROCR, NSFL1C, FLVCR2, MACF1, EXOC7, SLC7A11, THSD7A, ERVW-1, LAMP3, TRPC6, COLQ, AKT3, KCNK6, RASD1, TNFSF13B, SIGLEC7, ITM2B, ATP11B, NISCH, EPB41L3, STXBP5L, SLC27A6, CRYL1, SAMHD1, PKP3, L3MBTL1, TLN1, TCAF1, DAAM1, PLXND1, IRS2, GPSM3, PCDHB9, PCDHB14, PCDHA9, PCDHA13, PCDHA1, HRH3, TRPV2, CDC42BPB, SNX9, LYVE1, HCFC2, F11R, GPC6, WNT6, MRPL42, XRCC6BP1, SLC30A1, TNFRSF11A, SLC4A4, ENPP4, LOC440434

GO:0005887

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integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

ESYT2, SLC22A23, TMEM150B, TMEM150C, FXYD1, KCNK1, TLR4, GRM8, TNFRSF11B, SLC33A1, CLDN4, PLPP1, PLPP3, ENPP3, KCNK3, PRRG1, TNFSF11, TNFRSF10C, TSPAN4, EREG, PLXNB2, DCLK1, NPC1, MUSK, PLSCR1, SLC22A1, GRM6, GPR37, SLC16A6, SLC16A3, SLC31A1, SLC31A2, ABCC5, TLR3, CLDN3, FLRT2, AQP9, ATP8B1, TSPAN6, TYROBP, HS6ST1, ADCY3, FZD6, LY75, GPR137B, PLXNC1, ADCY9, TLR5, TLR2, TSPAN2, SLC16A7, SLC19A2, RAMP1, RAMP3, PLXNA2, ADAM23, GPR32, LGR5, GPC4, TNFRSF21, SLC22A3, CEACAM4, GABBR2, TM7SF2, SLC22A5, BEST1, AQP8, SLCO2B1, CSPG5, SLC25A14, MPZL1, ABCA1, SLC2A10, ECEL1, CLDN1, TSPAN13, TSPAN12, FADS2, CLPTM1, LDLR, TGFA, TNF, HLA-DRA, HLA-DQA2, HLA-DQA1, TFRC, OPN1SW, NTRK1, CYBB, SLC4A2, GYPC, APP, ITGB3, SLC25A5, ICAM1, INSR, ITGAV, CSF1R, ADRB2, IGF1R, NGFR, CHRM2, CD55, MME, PTPRC, MET, MFI2, ADRB1, CD48, LCT, PTPRF, CD28, GHR, SLC2A1, SLC2A3, CHRNB1, LAMP1, FGFR1, IGF2R, SLC25A4, GP1BB, ADRB3, SELL, CD99, DRD2, SLC2A4, IL1R1, PVR, IFNGR1, FOLR1, CD46, CD1D, MUC1, CD44, PDGFRA, EPCAM, ATP2A2, CD36, TMEM11, IFNAR1, GJA1, NPR3, CR1, ADRA2B, SDC1, TSPAN8, EPOR, CD58, CD53, FUT1, ATP2B1, HLA-DPA1, CD33, CHRM3, TNFRSF1B, NPR2, EFNA1, MAL, FPR1, CNR1, C5AR1, FGFR2, ERBB3, CD9, ENPP1, SLC2A5, LHCGR, MRC1, PTPRB, PTPRD, PTPRG, TNFSF4, ATP2B4, FSHR, IL4R, CXCR2, FPR2, ADRA1D, EDNRA, PTAFR, F2R, FAS, NPY1R, KLRC1, CD27, ACVR2A, STOM, HTR2C, PTPRM, TNFRSF8, ADORA2B, EPHA3, EPHB2, LTK, CD40LG, CNGA1, CD6, MIP, TM4SF1, AVPR2, SLC6A1, ADORA1, AGTR1, OXTR, SSTR1, GNRHR, SDC4, SLC6A6, GABRA5, CCKBR, GPR183, ABCC1, EVI2B, HTR7, GPC1, PHB, SSTR5, ADRA1A, HRH1, ADRA1B, PTGER4, TIE1, BSG, FLT4, GJA5, ACVR1B, LTBR, SCNN1A, IFNGR2, PMEL, OPRL1, AQP2, CD200, SLC19A1, ADCYAP1R1, HTR2B, TSPAN7, LIFR, SLC1A4, PTGFR, PTGER3, PTGER2, KIR3DL2, SLC6A8, MTNR1A, NPBWR1, GLRB, CD151, IFNAR2, SLC1A6, CD97, TRPC1, NPY2R, PTH2R, SLC11A1, SLC11A2, MTNR1B, PSEN1, PSEN2, AGTR2, MMP14, SLC26A2, TNFSF10, BCAM, SCNN1G, MMP15, MMP16, BCAP31, CAV2, CLCN4, CLCN5, CLCNKA, CLCNKB, PLXNA3, HNRNPM, SLC7A2, EFNA4, EFNB2, EPHA5, EPHB4, EPHB1, EPHA4, SLC12A2, F2RL1, JAM2, FXYD4, CD81, TSPAN5, VAMP2, CXADR, ADAM8, OLR1, SLC35A1, JAG1, ADAM17, HLA-DRB3, SLC7A9, PKD1, ATP2C1, MPP1, SLC25A3, IL9R, CD83, SLC7A5, MC2R, ROR1, NRG1, TEK, GUCY2D, CAV1, TGFBR3, PLAUR, NOTCH2, ACVR1, CD164, SLC18A2, TYRO3, PCDH1, DDR1, SLC20A2, CD47, KCNA1, SMAGP, BST2, MERTK, GRIN2A, LRMP, PTPRJ, TSPAN31, PTGDR, PTK7, SLC14A1, SLC39A6, TCIRG1, TRPC3, PKD2, LAPTM5, ACVR2B, ALCAM, ENPP2, BMPR2, SELPLG, ADGRE1, GPR176, CAPRIN1, KCNJ12, FAT1, ITPR3, KCNJ11, SSPN, GRM3, GPNMB, SLMAP, CLCA4, SLC39A14, EBP, PRKD1, NECTIN1, PTPRK, P2RY14, TLR1, MMD, SLC1A5, NPY5R, SCN9A, ZYX, ADRM1, SLC15A2, ASIC2, LY6E, SGCB, NKG7, NTRK2, AMHR2, PTPRO, MICA, SLC4A8, HFE, ATP13A5, FAM26F, STEAP4, TENM4, SLC18B1, SLC39A4, CSPG4, KIAA1324, SLCO4C1, SLC16A12, BTN2A1, MAEA, PLPPR4, TMEM150A, SLCO6A1, KTN1, TRABD2A, CD163, SGMS1, SLC26A11, PDPN, APCDD1, NLGN4X, BEST3, NLGN1, MFSD2A, GOLM1, PLPP5, TRPV1, GPRC5A, SEMA6D, TSPAN14, SGMS2, SLC35G2, LRRC8C, SLC16A10, SCARB1, FRS2, SLC20A1, SLC38A5, APH1B, STAB2, SLC5A11, CLEC2B, AQP3, SLC7A6, SORL1, HAS2, NRCAM, HPS1, SLC5A5, SLCO2A1, TNFRSF25, KISS1R, APH1A, PERP, PLPPR2, VSIG2, DCBLD2, HHIP, TSPAN18, KCNK17, CSF3R, HBEGF, MUC4, S1PR3, GPER1, P2RX4, SIGMAR1, TM9SF2, SLC29A1, SYT11, TM2D1, LGR4, C1QTNF1, CADM1, SLC39A8, PCDHAC1, TRPV6, OPN3, SLC26A1, SEMA6A, SLC38A1, RHBG, TMEM245, SEMA6B, ATP13A3, CALHM2, ADGRL3, SLC28A3, KCNK12, TRPV4, PLGRKT, LGR6, SLC24A3, ANKH, TMEM8A, SLC40A1, ACKR4, IL1RAP, ATP13A2, SLC52A3, GPRC5C, NECTIN3, IL17RB, PAG1, STAB1, FLRT3, FLRT1, TENM3, GABBR1, KL, EPHA6, SLC23A2, SLC2A6, ASIC3, SLC7A8, SLCO3A1, ZDHHC2, LNPEP, PLXNA1, SLC25A13, NAGPA, PILRB, PILRA, NRXN1, SLC39A10, FZD4, SLC7A7, COL17A1, PCDHA7, PCDHA6, PCDHA4, SLC6A14, PROCR, TFR2, GPR34, SLC7A11, TRPC6, RCE1, SIGLEC7, CNPY2, PLXND1, PCDHB3, PCDHA8, PCDHA5, PCDHA3, PCDHA2, PCDHA11, PCDHA10, PCDHA1, PCDHAC2, HRH3, MMP24, TRPV2, LYVE1, GPC6, ADGRG1, HS3ST3B1, TNFRSF11A, SLC4A4

GO:0005889

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hydrogen:potassium-exchanging ATPase complex

A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present.

GM2A, ATP12A

GO:0005890

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sodium:potassium-exchanging ATPase complex

Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.

FXYD1, ATP1B1, ATP1A2, ATP1B3

GO:0005891

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voltage-gated calcium channel complex

A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.

CACNA1G, CACNB3, CACNA2D1, PDE4D, CACNA1C, CACNA1E, CACNG8, CACNG6

GO:0005892

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acetylcholine-gated channel complex

A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.

CHRNB1, CHRNA5, CHRNA7, STXBP5

GO:0005895

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interleukin-5 receptor complex

A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3.

SDCBP

GO:0005896

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interleukin-6 receptor complex

A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130.

IL6, IL6R, IL6ST

GO:0005899

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insulin receptor complex

A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.

INSR, IRS1, SORBS1

GO:0005900

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oncostatin-M receptor complex

A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta.

IL6ST, OSMR

GO:0005901

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caveola

A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.

JAK2, LRP6, FLOT1, ATP1B1, INSR, HMOX1, SLC2A1, SELE, ATP2B4, F2R, MAPK3, MAPK1, NOS3, PTGS2, IRS1, BMPR1A, TGFBR2, ADCYAP1R1, ATP1A2, CAV2, EFNA5, ATP1B3, CDH13, CDH15, CAV1, LIPE, KCNMA1, AKAP6, CLN3, PTCH1, BMPR2, PTGIS, PTRF, SPRED1, BVES, KIF18A, SCARB1, PRKCDBP, DLC1, RANGRF, HDAC6

GO:0005902

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microvillus

Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.

MYO1G, MYO1C, CA2, TGFB1, PDGFA, CNP, EZR, VCAM1, ATP6V1B2, OXTR, RDX, CRB1, TEK, HYAL2, IQGAP2, ANGPT1, FSCN1, AOC3, SLC27A4, DCXR, CD302, EXOC4, BBS2, KIF13B, FMN2, MYO6

GO:0005903

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brush border

The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

MYO1C, CLIC1, ACTN4, FLNB, DAB1, MYO1D, MME, ACTN1, EZR, MYH9, MYL6, ACTR3, EPS8, MYO1E, RALGDS, ITPR3, PLS1, DCXR, CDHR2, ADD3, LIMA1

GO:0005905

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clathrin-coated pit

A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.

LDLR, TFRC, TF, APP, HSPD1, SLC2A4, SELE, EPS15, AP1S2, AP1S1, DAB2, VLDLR, LRP2, OCRL, TNK2, FCHO2, PICALM, CTTN, ITSN1, AAK1, LRP10, CEMIP, REPS1, FNBP1, SH3BP4, MYO6, AP4S1

GO:0005911

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cell-cell junction

A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.

SNAP23, KRIT1, CASK, PDZD2, NPHP1, FLRT2, ACTN4, CTNND1, WDR1, FLOT1, PLEKHG5, APP, KRT8, ANXA2, ITGA5, KIT, SLC2A1, ACTN1, JUP, VAV1, CDH2, CD53, FLNA, PIK3R1, PTPRM, CORO1A, AKT1, CDH5, CTNNA1, CTNNB1, MAP2K2, CSK, LIMS1, CDC42, ACTR3, PPP1CA, GRB2, CXADR, ADAM17, TEK, PRKCD, PCDH1, TWF1, PTPRJ, DLG1, MYO1E, TIAM1, STX3, PTK7, ILK, PKD2, BMPR2, DSG2, FAT1, PRKD1, PTPRK, OCLN, FSCN1, PDZD11, COL13A1, CDC42BPA, SV2A, SDCCAG8, IQGAP3, AHI1, PARD3, FRS2, AQP3, AJUBA, MAGI1, MYADM, PKP4, CDCA3, PKP2, TMEM47, CADM1, PNN, C10orf54, ECT2, LIN7B, ADGRL3, PDLIM7, LIN7C, FLRT3, FLRT1, ADD3, LIMD1, MYH2, HEG1, FZD4, COL17A1, PIKFYVE, EPB41L3, PKP3, TLN1, CDC42BPB, F11R

GO:0005912

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adherens junction

A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.

SDCBP, PLPP3, NPHP1, CTNNA2, CDH5, CTNNB1, NF2, NOTCH1, EFNA5, CXADR, JAG1, TNK2, MYO1E, NECTIN1, PTPRK, PIANP, AHI1, SHROOM3, AJUBA, MAGI1, FAM129B, PKP2, TMEM47, TBCD, WNK3, SPTBN4, TRPV4, VEZT, LIMD1

GO:0005913

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cell-cell adherens junction

An adherens junction which connects a cell to another cell.

ESYT2, PDLIM1, CLIC1, SDCBP, NOP56, DDX3X, CCS, SMAD7, PPL, EXOC3, CTNND1, FLNB, IDH1, FLOT1, RSL1D1, CCNB2, VAPB, LYPLA2, LDHA, EGFR, ALDOA, ANXA1, ITGB1, KRT18, ENO1, ANXA2, PFN1, LYN, SLC3A2, HSP90AB1, HSPA1A, HSPA1B, HSPA5, EEF2, PKM, JUP, PVR, EZR, RPS2, CDH2, CAST, FLNA, PCMT1, PAICS, ITGA6, APC, DNAJB1, S100P, CTNNA2, PTPRM, EEF1D, PRDX6, OXTR, YWHAB, SFN, S100A11, CTNNA1, CTNNB1, RDX, MYH9, BSG, TAGLN2, CAPG, EIF2S3, CD200, TMPO, TMPO, EPS15, RANBP1, RANGAP1, CRKL, IQGAP1, CAPZB, RPL29, CSNK1D, RPL34, FASN, NUMB, MRE11A, EMD, RPL14, CCT8, CAPZA1, ARFIP1, IST1, RARS, EIF5, RPL15, YWHAE, RPL7A, RPL23A, RAB1A, RPS26, YWHAZ, RACK1, HIST1H3D, RPL24, HDLBP, SPTBN1, DSC2, CALD1, PRDX1, TJP1, GOLGA2, AHNAK, SMAGP, TWF1, DLG1, PAK2, PICALM, SNX1, SHROOM2, CKAP5, DAG1, CTTN, TRIM25, SEPT2, STK38, NECTIN1, PCBP1, CNN3, MAPRE1, RAB11B, ZYX, SEPT7, PKN2, DBN1, FSCN1, LRRFIP1, COBLL1, FNBP1L, ARHGEF16, TWF2, LARP1, MPRIP, GIGYF2, BZW1, DHX29, PHLDB2, KTN1, ERC1, ABI1, ARHGAP18, SERBP1, GPRC5A, STXBP6, KIAA1524, DLG5, ZC3H15, PPP1R13L, ATXN2L, H1FX, NDRG1, GCN1, EFHD2, PDLIM5, SCYL1, FMNL2, FAM129B, PKP2, CORO1B, SORBS1, CADM1, EHD4, CHMP4B, EPB41L1, RTN4, NECTIN3, ANLN, DIAPH3, PARVA, ARGLU1, VAPA, TJP2, TES, LIMA1, BAIAP2L1, PUF60, ASAP1, MKL2, MYO6, MACF1, RUVBL1, SSX2IP, SH3GLB1, PKP3, TLN1, PPME1, SNX9, SNX5, F11R, STK24, BZW2, WASF2

GO:0005915

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zonula adherens

A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.

CTNND1, JUP, CTNNA1, SORBS1, CAMSAP3

GO:0005916

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fascia adherens

A cell-cell adherens junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.

ACTN1, JUP, DSP, GJA1, DES, CDH2, CTNNB1

GO:0005921

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gap junction

A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins.

GJA1, CALB2, MIP, GJA5, GJC1, TJP1, DBN1, PANX2, PANX1

GO:0005922

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connexin complex

An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.

GJA1, GJA5, GJC1

GO:0005923

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bicellular tight junction

An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.

CCDC85C, CLDN4, NPHP1, CLDN3, CLDN1, CDK4, EPCAM, APC, CDH5, CTNNB1, TGFBR1, ADCYAP1R1, PRKCI, JAM2, RAP2B, CXADR, PMP22, TJP1, ANK3, DLG1, SHROOM2, OCLN, AMOT, TJAP1, NHS, MTDH, MAGI2, AMOTL1, MPP5, BVES, INADL, PARD3, SYMPK, ARHGEF2, MARVELD3, MAGI1, TBCD, JAM3, PARD6B, WNK3, EPB41L4B, ECT2, LIN7B, PARD6A, ASH1L, LIN7C, VAPA, FRMD4A, TJP2, F11R

GO:0005924

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cell-substrate adherens junction

An adherens junction which connects a cell to the extracellular matrix.

SORBS1

GO:0005925

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focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

PDLIM1, SNAP23, SDCBP, ADAM10, NRP1, TSPAN4, CASK, PPP1R12A, ARPC2, ARPC3, ZNF185, CAPN5, FLRT2, TGFB1I1, ACTN4, PIP5K1C, SORBS3, LPXN, FLNB, FLOT1, SORBS2, MPZL1, EGFR, PLAU, KRAS, ANXA1, HSPB1, SLC4A2, ITGB3, ICAM1, RPLP1, RPLP2, RPLP0, ITGB1, NPM1, ITGAV, P4HB, PFN1, ANXA6, MME, PTPRC, ITGA5, VIM, RPS17, ANXA5, PDGFRB, HSPA1A, HSPA1B, RRAS, HSPA5, RALA, IGF2R, ACTN1, LCP1, PRKAR2A, CD99, HSP90B1, JUP, PVR, RAC2, EZR, CD46, RPS2, CD44, HMGA1, ITGA2, GJA1, ITGB5, RPL7, SDC1, CDH2, CSRP1, FLNA, CD9, TGM2, ITGA6, PPIB, JAK1, CFL1, TNC, ITGA3, MAPK3, DPP4, CALR, MAPK1, LAP3, MARCKS, RPL12, PDIA3, CCND3, S100A7, SDC4, YWHAB, GRK5, CTNNA1, CTNNB1, RDX, RPL22, MYH9, ACTN2, BSG, MAP2K2, RPL4, PPP1CC, RPL13A, MCAM, RPL5, RPS9, RPS5, RPS10, IQGAP1, LIMS1, CD151, CD97, NUMB, MMP14, GDI2, CAV2, CNN1, EFNB2, CDH13, CD81, ACTB, CDC42, ACTR3, ACTR2, RPS3A, RPL27, RPL37A, RHOA, B2M, RRAS2, RPS7, PPP1CB, RPS8, RPS16, YWHAE, RPS14, RPS18, RPS13, RPS11, RPL7A, RHOB, GNB2, RPL30, RPL31, RPL10A, PPIA, RAC1, YWHAZ, RPL38, ACTG1, TPM4, ACTC1, ADAM17, ARF1, RPL19, DAB2, HSPG2, KIF23, MAP2K1, TEK, DST, GNA12, CAV1, PLAUR, PTK2, RPL18, AHNAK, NEXN, TWF1, G3BP1, PTK7, ILK, SNTB2, ADAM9, FHL1, ALCAM, SNTB1, DAG1, ARHGEF7, GIT2, CTTN, FLNC, NEDD9, FAT1, MDC1, KIF22, CNN3, DIXDC1, TRIP6, ZYX, CSRP2, ARHGAP31, DCAF6, TNS2, NHS, CSPG4, MPRIP, RHOU, CYFIP1, ARHGAP22, PHLDB2, PRUNE, ARHGAP24, ENAH, PDCD6IP, FBLIM1, PALLD, SYNE2, STARD8, ARHGEF2, LPP, TADA1, AJUBA, PDLIM2, DOCK7, DLC1, CHP1, ZFYVE21, AIF1L, FERMT1, CORO1B, SORBS1, SPRY4, TRIOBP, TRPV4, TNS1, NOX4, CASS4, PDLIM7, PARVA, AATF, EHD3, FLRT3, FLRT1, HACD3, TES, LIMD1, LAMTOR3, LIMA1, EVL, ITGA11, RAB21, CORO1C, SYNPO2, ARHGAP26, PROCR, GIT1, REXO2, TLN1, HYOU1

GO:0005929

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cilium

A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.

SNTN, AURKA, ADCY3, CEP104, TULP3, OFD1, DNAL4, TUBB4A, DLD, GLI3, PKM, CCT8, NEK4, EVC, PKD1, CAV1, DNAH14, PKD2, TTLL9, CFAP157, DNAH12, BBS12, NPHP3, NEK8, PKHD1L1, DNAH10, AHI1, BBS10, TTC8, TEKT1, CLUAP1, IFT43, TMEM80, IFT74, IFT27, TRPV4, IFT122, TMEM138, IFT46, TULP4, WDR35, DNAI1, INVS, ATP6V1D

GO:0005930

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axoneme

The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.

DNALI1, TULP3, GLI2, GLI3, MAPT, MAK, CENPF, SEPT2, SEPT7, ARMC4, RSPH4A, CCDC103, BBS7, CFAP46, PIK3C3, MNS1, BBS1, DYNC2LI1, DNAH5, KIFAP3, WDR34, AK8, DRC1, PIK3R4, MAP1LC3B, INPP5E, DNAH9, SPATA7, WDR35, DCDC2

GO:0005938

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cell cortex

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

AXIN1, COBL, FLNB, USP2, FGA, FGB, FGG, ANXA2, PFN1, FGFR2, CTGF, MARCKS, AKT2, CTNNB1, SNCA, PSEN2, GYS2, RHOA, GPSM2, DST, CAV1, COL10A1, PTK2, AKAP13, EPS8, MYO9B, ARHGEF7, CTTN, NEDD9, ITPR2, MELK, SEPT2, PRKD1, TRIP10, DBN1, FAM110C, FNBP1L, FRY, AGTRAP, C2CD5, CD302, PARD3, FBLIM1, FNBP1, NDFIP1, PARD6B, TLE6, MYO10, PARD6A, FMN2, CLIC5, BIN2, ADD3, MKLN1, MYO6, PLA2G4C