| GO ID |
Ontology |
GO Term |
Term Definition |
Proteins |
|
GO:0005576
|
CC
|
extracellular region
|
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
VWA8,
IGIP,
MASP2,
TNFRSF11B,
RNASET2,
ISLR,
NCAN,
PRRG1,
TNFSF11,
EREG,
PDZD2,
SEMA3E,
NPC1,
ANGPT2,
ADAM12,
KLK10,
SPINT2,
ACTN4,
CALU,
CD5L,
NRP2,
FCMR,
ADAM23,
WDR1,
TULP3,
CA11,
LRP6,
TNFSF13,
FGF18,
SLIT2,
DKK1,
NXPH3,
CSPG5,
BMP10,
FGF19,
IL33,
EFEMP2,
F8,
F13A1,
F2,
C1R,
HP,
PLG,
PLAU,
PLAT,
CFB,
SERPINC1,
SERPINA1,
SERPINA3,
AGT,
A2M,
C3,
TIMP1,
CST3,
KNG1,
PDGFB,
TGFB1,
NGF,
GNRH1,
POMC,
PENK,
CGA,
FSHB,
LHB,
PRL,
GH1,
PTH,
GCG,
GHRH,
INS,
IGF2,
TNF,
IFNA1 ,
IL1A,
IL1B,
COL1A1,
COL3A1,
APOA1,
APOE,
APOA2,
APOC3,
FGA,
FGB,
FGG,
CRP,
APCS,
C1QA,
APOH,
LRG1,
FN1,
RBP4,
AMBP,
ORM1,
AHSG,
TTR,
ALB,
GC,
PPBP,
PF4,
TFRC,
TF,
ANG,
MMP1,
AMH,
VTN,
ALDOA,
ANXA1,
PDGFA,
APOB,
A1BG,
S100B,
VWF,
SHBG,
PRB1,
IFNA16,
IGF1,
CHGB,
APP,
APOD,
S100A8,
INHA,
SERPINE1,
SERPINA5,
SERPING1,
CFI,
F13B,
ISG15,
IL6,
EDN1,
SCG5,
CLEC3B,
COL5A2,
CCK,
S100A9,
LPL,
SERPINE2,
P4HB,
KLK3,
CTSD,
C8G,
TUBB,
PRSS1,
DCN,
PSAP,
CTSL,
CTSB,
HSP90AA1,
LAMB1,
THBS1,
COL1A2,
NGFR,
CD55,
CELA2B,
MMP2,
SOD3,
INHBA,
CD14,
COL4A2,
MET,
CFH,
IGFBP1,
IL6R,
NMB,
FGF2,
MMP10,
CXCL1,
HMGB1,
PAEP,
SPARC,
INHBB,
WNT2,
SCT,
C1S,
C4A,
C4B,
SAA1,
CGB5,
CGB7,
SRGN,
CXCL8,
CCL3,
RNASE2,
SPP1,
C7,
TFPI,
CLU,
GHR,
HAPLN1,
IAPP,
LAMC1,
MBL2,
FGFR1,
SFTPC,
COL11A1,
COL6A1,
COL6A2,
COL6A3,
F5,
PTHLH,
BMP2,
BMP4,
ACTN1,
ACE,
DEFA4,
CCL4,
BMP1,
CCL2,
CCL5,
VCAN,
C6,
PRG2,
COL11A2,
MIF,
HGF,
NID1,
PLA2G2A,
HSP90B1,
IL1R1,
MMP9,
LIF,
VEGFA,
TIMP2,
PRLR,
NPPB,
IL7R,
IGFBP3,
IGFBP2,
EPOR,
ORM2,
CXCL2,
FST,
KLK2,
TNFRSF1B,
TRH,
OGN,
EDN2,
IL11,
EFNA1,
COL9A1,
COL5A1,
FLNA,
KITLG,
MDK,
ZP3,
FGF7,
BGN,
GPX3,
GAL,
IGFBP4,
MMP8,
FBLN1,
ANOS1,
CBLN1,
BDNF,
LAMA2,
MMP11,
IGFBP6,
IGFBP5,
TNC,
COL8A2,
F2R,
AZGP1,
CTSS,
COL5A3,
PTX3,
CD27,
MST1,
PON1,
CALR,
CFP,
IL1R2,
AOAH,
LOX,
CTGF,
EPHA3,
EPHB2,
IL12A,
CASP1,
CD6,
LRPAP1,
NTS,
S100A7,
FGF9,
GBP1,
RNASE4,
PRSS3,
BTC,
ADM,
THBS4,
FBN1,
FBN2,
ACTN2,
TIMP3,
FLT4,
MAP2K2,
SERPINF1,
SNCA,
COL15A1,
COL18A1,
PLA2G5,
IL6ST,
ADH7,
PMEL,
LEP,
WNT5A,
PTGDS,
CXCL5,
GDF5,
PTGFR,
CTSK,
NOTCH1,
NPTX2,
GLIPR1,
CXCL12,
LEPR,
IFNAR2,
NMU,
CASP4,
COMP,
PGF,
VEGFB,
VEGFC,
SEPP1,
AGTR2,
TNFSF10,
PPT1,
INSL3,
LUM,
EFNA4,
EFNA5,
CAPZA1,
CRISP3,
EPHB4,
EPHB1,
MFAP2,
MFAP3,
INHBC,
GFER,
WNT3,
ANTXR2,
NXPH1,
PTEN,
ZP1,
LYZ,
B2M,
TGFB2,
CALM2,
TMSB4X,
HIST1H4A,
PPIA,
TUBA4A,
HIST1H3D,
HBB,
HBA1,
CXADR,
JAG1,
CCL20,
CXCL6,
LCN2,
HAMP,
CRB1,
HTRA3,
H3F3A,
FBLN2,
HSPG2,
IL9R,
COL4A3,
NRG1,
MUC3A,
TEK,
COL10A1,
NOTCH2,
CD164,
COL14A1,
FMOD,
COL16A1,
LOXL1,
MFGE8,
GALNT1,
ST3GAL3,
EFEMP1,
FSTL1,
PSG7,
PLA2G7,
SPP2,
MMRN1,
PAPPA,
CHIT1,
MFAP5,
COL4A6,
NID2,
IL18,
DAG1,
GAS6,
SEMA3A,
LTBP1,
KARS,
NECTIN1,
ERBB4,
ANGPT1,
FCN2,
RGN,
TGFBI,
KISS1,
CLUL1,
ADIPOQ,
IGFBP7,
LAMA4,
PSG3,
CTF1,
LAMA3,
ST3GAL2,
MST1L,
MMEL1,
BOLA3,
PDZD11,
HABP4,
COL13A1,
ABHD17B,
SUSD4,
OLFML2B,
C12orf73,
CTRB2,
LAIR2,
APOA5,
CSPG4,
ENHO,
ARSK,
DHRS13,
FAM150B,
FAM131A,
PAMR1,
IL34,
NOTCH2NL,
FAM19A5,
LYG2,
C6orf1,
ITIH5,
VASH2,
CD163,
CHSY1,
WFDC3,
VSTM4,
GLB1L2,
CNTN4,
SCUBE3,
LAS2,
LYPD1,
AGGF1,
MUC20,
MUC15,
PRSS35,
SFRP1,
C2orf69,
HSD17B11,
NPB,
LILRB1,
FIBIN,
SPATA20,
NDNF,
BPIFB1,
DEFB104A,
CYB5D2,
CEMIP,
C1orf54,
TTN,
FAM3C,
HSPH1,
ESR2,
HTRA1,
TNR,
NRCAM,
FGF13,
FGF11,
FGF14,
PRG4,
TNFRSF25,
WNT2B,
MR1,
VWCE,
MUCL1,
RSPRY1,
BCAN,
APOLD1,
GLT1D1,
VSTM2L,
COL21A1,
HHIP,
GPX7,
CSF3R,
HBEGF,
NELL2,
PLIN2,
MMP19,
COL12A1,
PROL1,
EGFL8,
RARRES2,
OMD,
GDF15,
SOST,
APOL2,
CCDC3,
PRADC1,
NDFIP1,
MENT,
APOO,
C1QTNF7,
EMILIN2,
RSPO3,
UACA,
PLA2G12A,
SIGLEC1,
TINAGL1,
PDGFD,
WNT5B,
CXCL16,
GREM2,
TREM1,
NGRN,
IL1RAP,
ESM1,
CD163L1,
PDGFC,
IL17RB,
LTBP3,
ERAP1,
IL37,
DSPP,
CLCF1,
CKLF,
GABBR1,
GHRL,
KL,
FAM198A,
DMBT1,
FETUB,
TMEFF2,
LNPEP,
ENPP5,
HEG1,
APLN,
PYCARD,
COL17A1,
PCDHA6,
ADAMTS5,
PROCR,
TNFSF13B,
ITM2B,
BOLA1,
C2CD2,
TLN1,
HYOU1,
PCDHA10,
PCDHA1,
WIF1,
LIPG,
WNT6,
LAMC3
|
|
GO:0005577
|
CC
|
fibrinogen complex
|
A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.
|
FGA,
FGB,
FGG,
FN1,
THBS1,
FBLN1,
FGL2
|
|
GO:0005578
|
CC
|
proteinaceous extracellular matrix
|
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.
|
TNFRSF11B,
MATN2,
CHL1,
CYR61,
NCAN,
FLRT2,
COCH,
CILP,
TECTA,
GPC4,
CRTAP,
WISP2,
ECM2,
SLIT2,
WISP1,
PAPLN,
SERPINA1,
TIMP1,
TGFB1,
MMP1,
VWF,
ALPL,
MMP2,
MGP,
MMP10,
LGALS1,
WNT2,
HAPLN1,
COL6A2,
COL6A3,
BMP4,
BMP1,
VCAN,
MMP9,
VEGFA,
TIMP2,
OGN,
COL9A1,
ZP3,
BGN,
TNXB,
MMP8,
FBLN1,
ANOS1,
MMP11,
COL8A2,
CALR,
LOX,
CTGF,
GPC1,
FBN1,
TIMP3,
CHI3L1,
WNT5A,
TFPI2,
COMP,
MMP16,
LUM,
CRISP3,
WNT3,
ADAMTS12,
ADAMTS20,
ZP1,
GPLD1,
FBLN2,
IL1RL1,
TGFBR3,
COL10A1,
COL14A1,
FMOD,
COL16A1,
EFEMP1,
DGCR6,
SPARCL1,
LTBP1,
POSTN,
TGFBI,
HSD17B12,
CPZ,
OLFML2A,
CCBE1,
GLDN,
FBN3,
PODN,
SBSPON,
GPC2,
SFRP1,
NDNF,
ADAMTS17,
ADAMTS15,
ADAMTS18,
SPOCK2,
TNR,
GLG1,
WNT2B,
CTHRC1,
BCAN,
COL21A1,
MUC4,
MMP19,
EPYC,
OMD,
SPOCK3,
SOST,
SPON2,
EMILIN2,
CRISPLD2,
WNT5B,
SPON1,
CD248,
MMP25,
CRTAC1,
MMP26,
FLRT3,
FLRT1,
DSPP,
ADAMTS9,
ADAMTS7,
ADAMTS6,
ADAMTS5,
ADAMTS8,
HPSE,
MMP24,
GPC6,
WNT6,
LAMC3
|
|
GO:0005579
|
CC
|
membrane attack complex
|
A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
|
C8G,
C7,
C6
|
|
GO:0005581
|
CC
|
collagen trimer
|
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
|
C1QA,
MBL2,
COL6A2,
COL8A2,
LOX,
COL18A1,
COL10A1,
COL14A1,
FCN2,
ADIPOQ,
COLEC12,
CCBE1,
GLDN,
COL23A1,
CTHRC1,
COL21A1,
C1QTNF1,
C1QTNF7,
C1QTNF3,
EMILIN2,
COL17A1,
COLQ
|
|
GO:0005582
|
CC
|
collagen type XV trimer
|
A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils.
|
COL15A1
|
|
GO:0005583
|
CC
|
fibrillar collagen trimer
|
Any triple helical collagen trimer that forms fibrils.
|
TNXB,
LUM
|
|
GO:0005584
|
CC
|
collagen type I trimer
|
A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils.
|
COL1A1,
COL1A2
|
|
GO:0005586
|
CC
|
collagen type III trimer
|
A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils.
|
COL3A1
|
|
GO:0005587
|
CC
|
collagen type IV trimer
|
A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.
|
COL4A2,
COL4A3,
COL4A6
|
|
GO:0005588
|
CC
|
collagen type V trimer
|
A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils.
|
COL5A2,
COL5A1,
COL5A3
|
|
GO:0005589
|
CC
|
collagen type VI trimer
|
A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils.
|
DCN,
COL6A1,
COL6A3
|
|
GO:0005592
|
CC
|
collagen type XI trimer
|
A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils.
|
COL11A1,
COL11A2
|
|
GO:0005594
|
CC
|
collagen type IX trimer
|
A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils.
|
COL9A1
|
|
GO:0005595
|
CC
|
collagen type XII trimer
|
A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures.
|
COL12A1
|
|
GO:0005596
|
CC
|
collagen type XIV trimer
|
A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures.
|
COL14A1
|
|
GO:0005597
|
CC
|
collagen type XVI trimer
|
A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils.
|
COL16A1
|
|
GO:0005600
|
CC
|
collagen type XIII trimer
|
A collagen homotrimer of alpha1(XIII) chains; type XIII collagen triple helices span the plasma membrane.
|
COL13A1
|
|
GO:0005602
|
CC
|
complement component C1 complex
|
A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains.
|
C1QA
|
|
GO:0005604
|
CC
|
basement membrane
|
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
|
MATN2,
CASK,
EFEMP2,
TIMP1,
CST3,
VTN,
ANXA2,
LAMB1,
SPARC,
LAMC1,
NID1,
COL5A1,
FBLN1,
ITGA6,
LAMA2,
TNC,
COL8A2,
FGF9,
THBS4,
FBN1,
TIMP3,
SERPINF1,
COL18A1,
CD151,
EFNA5,
HSPG2,
COL4A3,
DST,
LOXL1,
NID2,
DAG1,
TGFBI,
LAMA4,
LAMA3,
CCDC80,
P3H2,
SMOC2,
NTN4,
ADAMTS1,
COL17A1,
SMC3,
LOXL2,
LAMC3
|
|
GO:0005605
|
CC
|
basal lamina
|
A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix.
|
FN1,
ANG,
NID1,
LAMA2,
DLG1,
LAMA4,
COLQ
|
|
GO:0005606
|
CC
|
laminin-1 complex
|
A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.
|
LAMB1,
LAMC1
|
|
GO:0005607
|
CC
|
laminin-2 complex
|
A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains.
|
LAMB1
|
|
GO:0005610
|
CC
|
laminin-5 complex
|
A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains.
|
LAMA3
|
|
GO:0005614
|
CC
|
interstitial matrix
|
A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens.
|
ECM2,
TNC,
ADAMTSL4,
CCDC80,
NAV2,
KAZALD1,
SMOC2
|
|
GO:0005615
|
CC
|
extracellular space
|
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
SSPO,
CNOT1,
LGALS8,
AGRP,
CLIC1,
TNFRSF11B,
KRIT1,
SDCBP,
RNASET2,
MAN2B1,
CHEK1,
NRP1,
TNFSF11,
MSTN,
EREG,
SEMA3E,
ANGPT2,
FLRT2,
DHH,
ACTN4,
CD5L,
ZFC3H1,
GDF9,
GREM1,
SRPX2,
HIST1H2BK,
RAMP1,
CILP,
ENTPD6,
GPC4,
CREG1,
SCRG1,
CRTAP,
TNFSF13,
LYZL6,
STC2,
WISP2,
FGF18,
ECM2,
SLIT2,
DKK1,
SEMA3D,
WISP1,
GDF11,
BMP10,
CXCL14,
IL33,
ANGPTL1,
SCGB1D2,
BMP15,
F8,
EGFR,
F2,
HP,
PLG,
PLAU,
PLAT,
CFB,
ADA,
CA2,
SPINK1,
SERPINC1,
SERPINA1,
SERPINA3,
AGT,
C3,
TIMP1,
CST3,
CSTA,
KNG1,
PDGFB,
TGFA,
TGFB1,
GNRH1,
POMC,
GH1,
PTH,
GCG,
GHRH,
INS,
IGF2,
TNF,
IFNA1 ,
IL1A,
IL1B,
COL1A1,
COL3A1,
APOA1,
APOE,
APOC3,
FGA,
FGB,
FGG,
CRP,
APCS,
APOH,
LRG1,
FN1,
RBP4,
AMBP,
ORM1,
AHSG,
TTR,
ALB,
GC,
PPBP,
PF4,
TFRC,
TF,
BGLAP,
ANG,
AMH,
SLPI,
VTN,
ALDOA,
CSTB,
ANXA1,
PDGFA,
APOB,
A1BG,
KRT1,
S100B,
HSPB1,
IFNA16,
IGF1,
APP,
APOD,
S100A8,
SERPINE1,
SERPINA5,
SERPING1,
CFI,
MPO,
ALPL,
IL6,
EDN1,
ICAM1,
FABP3,
CLEC3B,
CCK,
S100A9,
ENO1,
GPI,
LPL,
SERPINE2,
KLK3,
CTSD,
ANXA2,
DCN,
PSAP,
CTSL,
CTSB,
LAMB1,
THBS1,
COL1A2,
CELA2A,
CELA2B,
MMP2,
SOD3,
CD14,
MFI2,
CFH,
IGFBP1,
FGF2,
ENO2,
GSTP1,
CST2,
MMP10,
CXCL1,
LGALS1,
HMGB1,
SPARC,
INHBB,
CNP,
WNT2,
HMOX1,
CTSH,
SCT,
ALOX5,
C4A,
C4B,
UBC,
SAA1,
SAA2,
SRGN,
CXCL8,
CCL3,
SPP1,
TFPI,
KIT,
HSPD1,
CLU,
GHR,
IAPP,
LAMC1,
ITGAM,
MBL2,
SFTPC,
IGF2R,
COL6A2,
COL6A3,
F5,
PTHLH,
CKB,
BMP2,
BMP4,
BMP3,
ACTN1,
ACE,
DEFA4,
CCL4,
TDGF1,
LAMP2,
BMP1,
CCL2,
CCL5,
SCG2,
VCAN,
TPT1,
ALAD,
LCP1,
ENO3,
MTHFD2,
MIF,
HGF,
CPM,
PLA2G2A,
IDE,
MMP9,
LIF,
AKR1B1,
PVR,
CPN1,
B4GALT1,
ACPP,
EZR,
AREG,
VEGFA,
MUC1,
TIMP2,
PECAM1,
SELE,
CD36,
NPPB,
CPE,
LGALS3,
IGFBP3,
IGFBP2,
IL1RN,
PAM,
VCAM1,
ORM2,
CXCL2,
OGN,
EDN2,
IL11,
KITLG,
ZP3,
ERBB3,
CD9,
BMP6,
TNXB,
IL10,
GPX3,
ENPP1,
GAL,
IGFBP4,
MMP8,
FBLN1,
ANOS1,
PTPRG,
TNFSF4,
CFL1,
IL32,
IL4R,
IGFBP6,
TNC,
AZGP1,
MT3,
CTSS,
PTX3,
S100A4,
HMGB2,
MST1,
STOM,
PON1,
CALR,
CFP,
LOX,
GRN,
PCSK1,
PCSK6,
CTGF,
IL12A,
SERPINB3,
CD40LG,
PRDX6,
SERPINB1,
FGF9,
SFN,
S100A11,
STX2,
BMP8B,
PRSS3,
GPC1,
BTC,
RDX,
ADM,
THBS4,
KRT9,
FBN1,
TIMP3,
CHI3L1,
NUDT1,
GNL1,
SERPINB5,
SERPINF1,
SNCA,
RBMX,
COL15A1,
COL18A1,
MDH1,
LEP,
WNT5A,
PTGDS,
NBL1,
CXCL5,
GDF5,
MCAM,
CTSK,
NAMPT,
LGALS7,
XDH,
CXCL12,
IFNAR2,
SERPINB4,
CD97,
COMP,
PGF,
VEGFC,
SEPP1,
SERPINB9,
TNFSF10,
PPT1,
SMARCA4,
HDGF,
LUM,
STC1,
COPA,
CTSC,
CRISP3,
YARS,
INHBC,
CDH13,
WNT3,
ADAMTS20,
TPI1,
ACTB,
FGF12,
LYZ,
B2M,
TGFB2,
ACTA2,
HIST1H2BC,
GNB2,
PPIA,
RPS27A,
UBA52,
YWHAZ,
ACTG1,
ACTG2,
ACTC1,
EEF1A1,
BLOC1S1,
CCL20,
CCL8,
GPLD1,
CXCL6,
LCN2,
NUCB2,
DLK1,
HAMP,
TNFAIP6,
MUC5AC,
HSPG2,
NDP,
SORD,
IL9R,
IL5RA,
CTBS,
NUCB1,
TGFBR3,
TNFAIP2,
CFHR1,
COL14A1,
FMOD,
PRDX1,
C1QBP,
DDR1,
LOXL1,
MFGE8,
PDE4C,
PMPCA,
EFEMP1,
FSTL1,
STX4,
MERTK,
PRDX4,
SEMA3B,
PAPPA,
SELENBP1,
CHIT1,
ADAM9,
ASAH1,
PPP1R1A,
ENPP2,
BMPR2,
CDK13,
IL18,
DAG1,
DPYSL3,
GAS6,
WFDC2,
SPARCL1,
SEMA3A,
POSTN,
PCOLCE,
ANGPT1,
TGFBI,
KISS1,
ADIPOQ,
IGFBP7,
CARTPT,
CTF1,
PTGIS,
HIST2H2BE,
MICA,
RALGAPA2,
HFE,
SFRP5,
HDGFL1,
CPZ,
SFRP4,
CTRB2,
APOA5,
POTEE,
CBLN3,
CES3,
OLFM4,
CRELD2,
CCBE1,
LRIG3,
SOSTDC1,
GLDN,
IL34,
QSOX2,
KCP,
SSH2,
PODN,
BMP8A,
FJX1,
PKHD1L1,
IFNE,
THNSL2,
TMPRSS6,
AEBP1,
SERPINA12,
SULF2,
SULF1,
SCUBE1,
SLF2,
FAM20C,
CPNE9,
CPAMD8,
CMTM8,
GPC2,
SFRP1,
LRRC17,
BMPER,
FAM184A,
GOLM1,
PCSK9,
ENOX1,
DMXL2,
BPIFB1,
ADAMTS15,
SECTM1,
LIPH,
PIBF1,
DNAJC9,
SORL1,
HTRA1,
GGH,
PCSK5,
WNT2B,
MYDGF,
CTHRC1,
SAAL1,
CPB2,
LOXL4,
C9orf72,
CMTM3,
HBEGF,
MUC4,
SDF2,
SERPINI1,
S100A13,
EPYC,
COL12A1,
OLFM1,
PROL1,
OMD,
SEMA3C,
GDF15,
SOST,
AIFM2,
SPX,
FUCA2,
SPON2,
APOO,
GNL3,
JAM3,
C1QTNF1,
C1QTNF3,
ULBP2,
TINAGL1,
PDGFD,
WNT5B,
CXCL16,
MUC13,
SEMA4A,
GREM2,
FKRP,
WFDC1,
SPON1,
RETN,
PDGFC,
CBLN4,
VNN3,
MTMR4,
ERAP1,
GPRC5B,
IL37,
C1RL,
FLRT3,
FLRT1,
LMCD1,
ZSWIM5,
ADAMTS9,
ATXN10,
DKK3,
CTSZ,
CKLF,
DKK2,
GHRL,
CTSF,
KL,
PRKAG3,
DMBT1,
FETUB,
SERPINB13,
MTUS1,
APLN,
NENF,
ADAMTS5,
COLQ,
TNFSF13B,
ITM2B,
FRMD4B,
LOXL2,
HILPDA,
LIPG,
GPC6,
CPQ,
WNT6
|
|
GO:0005618
|
CC
|
cell wall
|
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
|
ATHL1
|
|
GO:0005622
|
CC
|
intracellular
|
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
|
DENND3,
ZBBX,
HSD17B6,
EREG,
MAST4,
DCLK1,
SMAD9,
TLR3,
TGFB1I1,
ACTN4,
TRAF3IP2,
TYROBP,
TBC1D4,
ADCY9,
EDF1,
RAMP1,
RAMP3,
PEX14,
TADA3,
BCAR3,
PROSC,
DIRAS3,
FGF19,
TBC1D8,
PNP,
SERPINA3,
PRL,
GH1,
PTH,
GHRH,
CD74,
ATP1B1,
CSF1R,
CTSB,
ANXA5,
GSTP1,
CXCL1,
LGALS1,
TBC1D3H,
CXCL8,
CCL3,
RRAS,
GHR,
ACTN1,
PRKCSH,
GSPT1,
ACPP,
STMN1,
NPR3,
IL1RN,
EDN2,
CAPN3,
EFNA1,
FPR1,
SAT1,
ERBB3,
TNXB,
IGFBP5,
CXCR2,
CD24,
MT3,
CALR,
ADORA2B,
LTK,
CD40LG,
AGTR1,
OXTR,
BTC,
PTGER4,
AKR1C3,
GDF5,
IFNAR2,
SERPINB4,
NPY2R,
SERPINB9,
CAV2,
ADCY7,
ADPRH,
RRAD,
GABARAPL2,
RAB5B,
NCALD,
GNB1,
CCL20,
GPLD1,
MPP1,
IL5RA,
ANK2,
CAV1,
PRKCQ,
TBC1D8B,
ARL16,
STX4,
MLLT11,
SNTA1,
RAB33A,
TRIM14,
INPP5A,
UBE3C,
ANGPT1,
ZNHIT3,
JMJD1C,
SMAD1,
VAMP3,
LGALSL,
ANO6,
C11orf73,
TRIM61,
KRBOX4,
GRTP1,
MLK4,
IRAK1BP1,
CHIC1,
TNS2,
TBC1D9B,
TBC1D3C,
ZNF880,
SPSB3,
DEF8,
TBC1D9,
PREX2,
ZNF720,
GPR126,
TRIM73,
STK32C,
TMPRSS6,
TRIM42,
FAM126B,
ABI1,
TBC1D3,
PARP8,
ASCC3,
SFRP1,
EID2,
PDZD8,
NCOA7,
DEPTOR,
NDNF,
TBC1D15,
RDH11,
CSGALNACT1,
BLNK,
NUDCD2,
MYLIP,
RIT1,
GLMN,
TRIM43,
DOCK10,
RUNDC1,
EVI5L,
RASD2,
RAB39B,
NUDT11,
ARL5B,
PGLYRP2,
NEDD4L,
TRNT1,
RASL10B,
SMC6,
GPER1,
SMAD5,
RASL11B,
HEPH,
TTPAL,
NUDT9,
FSD1L,
OSBPL1A,
B3GNT5,
MAP1LC3B,
C6orf62,
MKRN2,
GABARAPL1,
ATG10,
ALDH8A1,
SLC40A1,
PNPLA8,
TREM1,
MKKS,
RTN4,
ARHGEF3,
TNFRSF19,
PAG1,
DDIT4,
DDX43,
WSB2,
PLK2,
MAT2B,
GLTSCR2,
DOK5,
CLCF1,
KL,
LNPEP,
CDC23,
NUDT5,
HPCAL4,
POLI,
SNX6,
SSR3,
TBC1D2B,
RIMS2,
RUVBL2,
AKT3,
GSTK1,
SAMHD1,
HBS1L,
MFHAS1,
RNF114,
ADGRG1,
ARL5A,
WASF2
|
|
GO:0005623
|
CC
|
cell
|
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
HMGB2,
CCL8,
LCN2,
TEX14,
NHLRC2,
ATP6V0A1,
CPB2,
TXNDC15,
NELL2,
OLFM1,
C1QTNF3,
CAPN10,
DNAJC16
|
|
GO:0005634
|
CC
|
nucleus
|
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
RBM47,
E2F8,
MED19,
MEX3A,
UBE2QL1,
MACROD2,
ZC3H12D,
PTPDC1,
ZNF320,
CNOT1,
ZNF233,
ASB14,
SOBP,
ZNF785,
VGLL3,
PHF20L1,
CENPBD1,
ZNF879,
FAM195B,
NACA,
DDX39A,
EYA2,
APBB1,
PSMD11,
WRB,
SUPT5H,
DFFA,
HIP1,
CLIC1,
WWP2,
CDC7,
ARNTL,
WASL,
FOXN3,
IPO5,
IGF2BP3,
RTCA,
PIK3C2A,
IFRD1,
MEIS1,
HMGN4,
NR5A2,
ZNF593,
VWA5A,
SDCBP,
DDX3X,
NFIB,
FBP2,
ACACB,
PDXK,
ARID1A,
BHLHE40,
CDK2AP1,
DYNC1I1,
CCS,
CHD1,
CHD2,
ADAM10,
ENC1,
ITGB1BP1,
MAP2K7,
PDCD5,
CHEK1,
ZNF213,
NDC80,
TNPO2,
BACH1,
IRF6,
TAX1BP3,
RGS12,
AURKA,
DSCR3,
AZIN1,
XPO1,
ZNF646,
PDZD2,
U2SURP,
ZBTB5,
NACAD,
SMAD7,
FYB,
ANGPT2,
MDM4,
PLSCR1,
AXIN1,
CTDSPL,
SMAD9,
UBD,
OGT,
HMGB3,
PPM1G,
HDAC3,
BIRC5,
TOX3,
FOXP2,
CD3EAP,
P4HA2,
NUPL2,
POLR2D,
SOCS1,
MAFG,
PER1,
ZSCAN9,
KDM6A,
DHX15,
ZBTB24,
IRAK2,
PSMD3,
RBFOX2,
SIAH2,
ZNHIT1,
DAPK3,
ZNF264,
AP5Z1,
MAP3K7,
EEF1E1,
WDR62,
PRPF3,
TBX1,
CBFA2T2,
OIP5,
RAD51C,
FOXO3,
SMAD6,
SPRY2,
SNAI2,
PLRG1,
PRC1,
RGS10,
ZNF207,
LDB2,
TCF21,
ASNA1,
ACTN4,
SSNA1,
NUDT21,
IDH3B,
ORC5,
DHX16,
MED14,
SOX15,
PARK2,
SMARCA5,
NUAK1,
ZNF862,
TRAK2,
ZEB2,
PIP5K1C,
KDM1A,
NUPR1,
PPL,
MGEA5,
SORBS3,
SYNCRIP,
CREBL2,
NEMF,
CCNT1,
CCNT2,
RAD1,
REV3L,
JAK2,
YPEL1,
UGDH,
LPXN,
CTNND1,
CDC14B,
HIST1H2BK,
PQBP1,
DKC1,
EDF1,
BRD4,
SHOX2,
TBL1X,
PPP1R11,
NBN,
MITF,
ROCK2,
MFAP3L,
ZNF623,
TSC22D2,
CNOT3,
SIN3B,
DNAJB6,
GADD45B,
ZPR1,
DUSP11,
PDCD6,
ZNF253,
VPS4B,
H2AFY,
NCOR1,
PEX14,
TULP3,
TACC1,
MAF,
TADA2A,
SUPT3H,
GPC4,
SRSF10,
GMNN,
HSBP1,
KHDRBS3,
TADA3,
BANF1,
RPS6KA5,
MED6,
MYCBP2,
OFD1,
ADAP1,
TCEA3,
RAD51D,
POP7,
RPP40,
ZNF189,
PSMD10,
KLF7,
SASH3,
SEC14L2,
RNF8,
DXO,
RECQL4,
URI1,
STK17B,
USP1,
TPPP,
MICAL2,
SUPT7L,
SORBS2,
TOX,
NFAT5,
KDM4B,
CLSTN1,
HEXIM1,
UBR5,
FSBP,
PRSS23,
UBE4B,
ZFPL1,
OAZ2,
ZNF205,
ZRANB2,
ZWINT,
LUC7L3,
MBD4,
SBF1,
GADD45G,
EPM2A,
CELF2,
SMC2,
TACC2,
ZBTB7A,
CD2BP2,
PARN,
PSMG1,
NSA2,
TDP2,
POLR1A,
CNOT4,
STAMBP,
NFATC1,
EYA4,
APBB3,
PTBP3,
IL33,
WIZ,
AIFM1,
CLIC3,
CBX7,
NUDT3,
PTTG1,
BCL10,
ZBED1,
ACTL6A,
WHSC1,
LDHA,
PNP,
EGFR,
ASS1,
SERPINA3,
CSTA,
FOS,
MYC,
TGFB1,
CRYAB,
LMNA,
APOA1,
APOE,
APCS,
ALB,
FTH1,
MT2A,
ESR1,
ANG,
RAF1,
ALDOA,
ANXA1,
NR3C1,
PRNP,
MYCN,
KRT1,
S100B,
TUBB4A,
GAPDH,
ERBB2,
TP53,
MT1E,
MT1F,
HSPB1,
TYMS,
ITGB3,
S100A8,
SLC25A5,
MPO,
EIF2S1,
HMGN2,
RPLP0,
JUN,
SSB,
PRKCB,
KRT8,
FYN,
RB1,
PTMA,
CDK1,
S100A9,
S100A6,
ENO1,
NPM1,
TH,
CENPB,
KLK3,
ANXA2,
TUBB,
ADRB2,
CTSL,
PFN1,
HSP90AA1,
HNRNPC,
LYN,
ZFY,
NGFR,
SLC3A2,
MMP2,
SOD3,
PDHA1,
CYC1,
NFIC,
KRT7,
KRT16,
RPSA,
HOXC4,
FGF2,
HOXB5,
GSTP1,
LGALS1,
HMGB1,
ANXA4,
CNP,
HMOX1,
PDGFRB,
HNRNPA1,
PARP1,
POLA1,
H2AFZ,
HIST1H2AG,
ZNF688,
CHTF8,
UBC,
TRAPPC2,
GLI3,
TROVE2,
MYBL1,
AR,
HIST1H1E,
BCL2,
NR2F1,
TXN,
MGST1,
THRA,
CLU,
IRF1,
HSPA5,
EGR2,
UMPS,
PDHB,
FGFR1,
TOP1,
TOP2A,
G6PD,
VDR,
ESRRA,
CDK4,
PCNA,
SLC25A4,
TPR,
SKI,
XRCC5,
UNG,
EEF2,
MT1G,
KRT13,
TPT1,
ALAD,
ADRB3,
GTF2F2,
HCLS1,
PKM,
HSP90B1,
CCNB1,
TYR,
IDE,
POU2F1,
HNRNPL,
ETS1,
JUP,
ETS2,
FABP4,
ACPP,
FOLR1,
UCHL3,
FOSL1,
FOSL2,
AREG,
NME1,
ZNF44,
ZNF250,
HIVEP1,
RPS2,
TCF4,
RAG1,
TCF3,
DSP,
H2AFX,
ITGB4,
CREB1,
PDGFRA,
GCFC2,
HIST1H1C,
ZNF823,
CPE,
ZFX,
ZNF12,
ZNF14,
ZNF17,
ZNF19,
ZNF20,
ZNF182,
ZNF22,
ZNF23,
ZNF24,
ZKSCAN1,
ZNF25,
ZNF43,
HMGA1,
ITGA2,
UBTF,
JUND,
TAL1,
ATF7,
PRKACA,
CEBPB,
DDX5,
XBP1,
LGALS3,
IGFBP3,
PSMC3,
ERCC2,
RPL7,
EGR1,
RPL17,
RCC1,
ATF1,
ATF3,
ATF4,
ATF6,
LIG1,
POLR2E,
ELK1,
TFEB,
WT1,
NFKB1,
ATP2B1,
CCNA2,
BTF3,
TNFRSF1B,
NR1D1,
TRH,
PSMB1,
HIST1H2AD,
BCL3,
MAK,
CAPN3,
HNF1A,
PDC,
PTMS,
CDK11B,
GSTM3,
CSRP1,
FLNA,
TNFAIP3,
FGFR2,
OSBP,
RPS4Y1,
UBA1,
NME2,
HNRNPA2B1,
CALB2,
NR4A1,
XPA,
PTGS1,
SFPQ,
PPIB,
JAK1,
SP100,
AHCY,
CFL1,
DTYMK,
NR2F2,
GADD45A,
POLR2A,
CDK2,
APC,
MCM3,
NFYB,
AZGP1,
BRD2,
FAS,
YY1,
DNAJB1,
DNAJB2,
PSMA1,
PSMA2,
PSMA3,
PSMA4,
LMO2,
S100P,
CTNNA2,
DNMT1,
RPL13,
S100A4,
HMGB2,
ZFP36,
CD27,
MAPK3,
ARNT,
DCK,
CAD,
CALR,
PIK3R1,
PSMB4,
PSMB5,
SSFA2,
LOX,
POLD1,
HOXD10,
SMARCA1,
MAPK1,
DUSP1,
MZF1,
RXRB,
LAP3,
TPP2,
KDM5A,
TKT,
NOS3,
SERPINB3,
RBMS1,
EEF1D,
CMPK1,
PEBP1,
PDIA3,
PPP2R1A,
CDC27,
CCND2,
WEE1,
CDC25C,
POLR2B,
S100A7,
HOXA10,
HOXA6,
RRM2,
HIVEP2,
DNAJA1,
AKT1,
AKT2,
HNRNPH3,
HNRNPH1,
YWHAB,
SFN,
STIP1,
S100A11,
OTX2,
MC4R,
FOXN2,
CTH,
DUT,
HIST1H2BB,
MCM4,
MCM5,
SHMT1,
GRK5,
CTNNB1,
PHB,
NF2,
RPL22,
GTF2F1,
SSTR5,
ADRA1A,
PTGS2,
ADRA1B,
RORA,
CBS,
KRT9,
IRS1,
MYH9,
TIMP3,
FUS,
DDIT3,
DEK,
SOX6,
GLRX,
ZNF93,
AHR,
FLT4,
PSMC2,
TRIM23,
MAP2K2,
RPL4,
NUDT1,
PPP1CC,
GNL1,
POLR2I,
SREBF1,
DLST,
GPX4,
SRP14,
PPARG,
ZEB1,
TALDO1,
SNCA,
RBMX,
BRCA1,
COIL,
CDKN1A,
ANP32A,
FEN1,
CAPG,
PBX1,
PBX2,
RPL13A,
MLH1,
STAT3,
MDH2,
CCNF,
ID1,
ETV5,
BCL6,
MNDA,
RGS2,
BUD31,
UBA7,
EIF1,
PRKCI,
ELK3,
TMPO,
TMPO,
SKIV2L2,
AKR1C3,
PIK3CB,
RPS27,
HELZ,
LRPPRC,
CDKN2B,
CDKN2C,
NSG1,
HTT,
MCAM,
NR4A2,
SYK,
RANBP1,
PSMC4,
GATA4,
NKX2-1,
TSFM,
VDAC2,
CBX5,
MAPK8,
MKI67,
RECQL,
ATRX,
CDKN1B,
NOTCH1,
IER3,
BRCC3,
RPL5,
RPS9,
YAP1,
IQGAP1,
ID4,
LGALS7,
ZFP36L2,
ATP5O,
PREP,
TFPI2,
RFX2,
RFX5,
SOX9,
NRIP1,
PRRC2A,
CSNK1D,
MAPKAPK2,
SLC11A2,
NASP,
CDK8,
MRPL19,
ALDH7A1,
CDC34,
CENPA,
CENPF,
HOXA1,
CSNK1E,
CEBPD,
PSMB3,
MCM2,
ACADVL,
NUMB,
CLK2,
PSEN1,
HINT1,
FHIT,
RGS4,
TSC2,
GSK3B,
CDKN1C,
MRE11A,
MEOX1,
SERPINB9,
LHX2,
MXI1,
ERF,
ETV1,
ASCL1,
CDK7,
KNTC1,
PPT1,
PAPOLA,
DUSP3,
NOVA1,
ZNF83,
ZNF84,
DNA2,
SMARCA2,
SMARCA4,
BRCA2,
IRAK1,
CAV2,
PSMD7,
STAT5B,
USP11,
PLXNA3,
PRKX,
AFF3,
NR0B1,
NEK2,
NEK3,
UBE2E1,
HNRNPA3,
PGD,
KPNA1,
POLR2J,
ZNF133,
ZNF136,
ZNF140,
ZNF138,
RBM5,
HRSP12,
STC1,
HMGA2,
SLC25A1,
PLK1,
FOSB,
CEBPG,
LIMK2,
PTTG1IP,
POLR2K,
TTC3,
RCAN1,
SUB1,
BLM,
HIRA,
ATXN3,
ATXN1,
ATN1,
TERF1,
PMS1,
OAZ1,
YARS,
PRKAA2,
RAD23A,
RAD23B,
EMP2,
GEM,
NR1H2,
CSE1L,
VCP,
MLLT10,
NAP1L1,
CASP9,
FOXG1,
SNU13,
NPEPPS,
HNRNPH2,
SUMO3,
MAZ,
HDAC4,
EIF6,
CTBP2,
SIK1,
PRDM15,
SOX8,
MAP3K7CL,
GEMIN4,
KLF3,
SESN2,
SESN3,
FOXL2,
MTPN,
YBEY,
HIST1H2BD,
ZNF445,
TPI1,
PTEN,
PPP4C,
SRP54,
RAB2A,
RPS3A,
PSME3,
RPL15,
FGF12,
RPL27,
RPL37A,
PKIA,
SUMO2,
UFM1,
RPS7,
PPP1CA,
PPP1CB,
CALM2,
PSMC1,
RPS8,
RPS18,
RPS13,
LSM3,
SNRPD1,
BTG1,
PSMC6,
RPL7A,
POLR2G,
PPP2CB,
RHOB,
RPL23A,
RPS6,
HIST1H4A,
HIST1H2BC,
RPS25,
POLR2L,
RPL30,
RPL10A,
PPIA,
RPS27A,
UBA52,
GRB2,
TRA2B,
RAC1,
GNAI1,
YWHAZ,
UBE2B,
SNRPN,
DYNLL1,
SKP1,
EIF5A,
RACK1,
ACTG1,
UBE2I,
YBX1,
EEF1A1,
TUBB4B,
HIST1H3D,
RBM6,
RPP30,
GTF2I,
SRPK2,
SLC35A2,
RAE1,
IRX3,
ELF3,
NTHL1,
CRADD,
MT1H,
MT1X,
SIM1,
SSBP2,
TMF1,
SARNP,
SMAD3,
SERF2,
H3F3A,
FOXK1,
ZBED6,
PKD1,
ZXDB,
XIAP,
FOXO4,
RBM3,
ZNF200,
CYCS,
TFAM,
SLC25A3,
HDLBP,
GTF2B,
CDK6,
CDK5,
PURA,
FKBP3,
HNRNPU,
IRF9,
MDM2,
E2F1,
INSM1,
SET,
SRSF2,
RUNX1,
RELB,
HMGCS1,
DR1,
SATB1,
XPC,
EWSR1,
POU5F1,
BNC1,
OCRL,
MEF2A,
CENPE,
KIF23,
NRG1,
ID2,
APBA1,
SP3,
ID3,
MAP2K1,
NUCB1,
CREB5,
DST,
HHEX,
POU3F1,
CREM,
PPARD,
CENPC,
CEBPZ,
ZNF85,
ZNF117,
ZNF92,
RELA,
NOTCH2,
TLE1,
TLE3,
EMX2,
SSBP1,
REL,
MXD1,
EGR4,
PTK2,
ZNF91,
ZBTB16,
SRSF11,
PRKCD,
DUSP2,
PTPN11,
EXOSC9,
MEF2C,
TYRO3,
APLP2,
GABPA,
RING1,
RAD51,
PAX8,
ZNF33A,
FMR1,
PRDX1,
EGR3,
SOX4,
RPL18,
C1QBP,
TJP1,
ZFP36L1,
KHDRBS1,
DLX2,
BAX,
MCL1,
POLE,
PPARA,
TNK2,
SRSF1,
FOXM1,
AES,
GOLGA2,
PPID,
SSRP1,
SLFN5,
ZNF844,
ZNF616,
NSUN2,
RBBP4,
NCBP1,
EP300,
AHNAK,
ZNF763,
ZNF816,
SREBF2,
ARHGEF5,
FOXO1,
TBL3,
PNRC1,
TFCP2,
AKAP13,
CDC20,
TCF15,
IFRD2,
ILF2,
ILF3,
FOXC1,
DLG1,
TAF10,
RALGDS,
PTP4A2,
BNIP3,
HSPB3,
CSTF3,
TIAM1,
MLLT11,
PRDM2,
STK4,
CHAF1A,
CHAF1B,
KLF10,
MTAP,
NR1H3,
CALCOCO2,
EIF2B5,
TARDBP,
PRDX4,
MAP2K5,
MAPK7,
CBX3,
PSMD2,
DUSP8,
SRSF5,
MAD2L1,
TRIM28,
G3BP1,
CLN3,
SKP2,
MTA1,
ITGB3BP,
PPIL2,
PPP2R5C,
MAB21L1,
ZNF211,
UBE2V1,
ORC1,
IKZF1,
XRCC4,
PPIG,
TCOF1,
NFATC2,
SMAD4,
BIRC3,
PICALM,
MAMLD1,
TUBB3,
C1orf61,
HDAC1,
CAMK2D,
NAE1,
TDG,
DGKZ,
TRA2A,
PWP1,
MTMR2,
TP53BP2,
FHL1,
TUBA3C,
RUNX3,
NACA,
NCOA4,
PMAIP1,
BLMH,
EXOSC2,
TUBB2A,
KLF9,
C1D,
CUX1,
RUNX2,
NFYC,
CIRBP,
CAMK1,
COTL1,
HNRNPD,
TOB2,
VEZF1,
DGCR6,
BOP1,
EIF3A,
TFDP1,
NPAT,
FAM50A,
HES1,
SLBP,
NFE2L1,
NEDD9,
FAT1,
MCM6,
MXD4,
ZNF345,
ZNF268,
ZNF273,
ESPL1,
MDC1,
KANK1,
MELK,
SMC1A,
RRP1B,
DIP2A,
GINS1,
LPIN1,
PPP2R5D,
ZNF846,
KIF22,
MEF2D,
CHD4,
POU6F1,
ARID5B,
MTF1,
DRAP1,
NFATC4,
NR1D2,
PSME4,
CUL7,
SHPRH,
ARHGAP19,
NCAPH,
KIAA0101,
EMC2,
WTAP,
MORF4L2,
SEPT2,
SART3,
NCAPD2,
SUZ12,
EXOSC7,
HERC3,
KARS,
RRS1,
POLD3,
KIF14,
BRD3,
ACOX1,
PRKD1,
TCEAL1,
PPP2R5A,
PTGES3,
STK38,
NONO,
PPP2R4,
RNPS1,
RBBP5,
ERBB4,
ZMYND11,
ANKRD1,
RPS6KA2,
UBE3C,
DHCR24,
DLGAP5,
RPS6KA1,
RBMS2,
PPP1R7,
NR0B2,
RGN,
TAF5,
TEAD2,
TAF1A,
NCOA2,
TRADD,
TSN,
TRIP11,
TRIP13,
JMJD1C,
TRIP6,
TWIST1,
TSC22D1,
ELAVL1,
SMAD2,
SMAD1,
UBE2V2,
STK11,
CCDC85B,
NEDD8,
ADIRF,
USF2,
EZH2,
ZFHX3,
ZIC1,
ZNF141,
ZNF77,
ZYX,
ZNF124,
HSPB2,
SEPT7,
PDCD2,
PKN1,
PKN2,
CRY1,
CSRP2,
SNAPC1,
HLF,
MAPK14,
SNRNP35,
NREP,
PTGIS,
NFIL3,
HIF1A,
IFI16,
CDKN3,
ZSCAN26,
DECR1,
HIST2H2BE,
UGP2,
DGUOK,
TXNRD1,
TATDN3,
CPEB4,
SWI5,
PDS5A,
ZNF423,
ZNF630,
LRRFIP1,
TRMT5,
NDUFAF6,
PCGF3,
ZNF791,
CHD9,
TKFC,
ZSCAN23,
GON4L,
TBRG1,
RABL6,
ZNF568,
ZNF404,
ZFP69,
LARP7,
FILIP1L,
ARID4B,
MORN2,
FAM98B,
PDCD4,
NCBP3,
C11orf73,
PLEKHO1,
CDCA8,
TAF1B,
INO80D,
ZNF385B,
ESCO2,
DCAF6,
ODF2,
NOM1,
CMPK2,
ZNF789,
HERC4,
ZMAT1,
ZNF766,
FAM76B,
ZNF667,
ZNF506,
HABP4,
SPECC1,
SAMD4B,
DNTTIP2,
RABGAP1L,
ZBTB41,
HIVEP3,
ARMC4,
LRIF1,
ZNF684,
ZNF648,
ZNF618,
ERCC6L2,
ACBD5,
DCAF8,
DEPDC1,
RNASEH2B,
BCL2L15,
RSPH4A,
THEMIS2,
HDGFL1,
STPG1,
ZNF658,
MEX3C,
HECTD2,
ATF7IP2,
RIF1,
STRIP1,
PDE4DIP,
IRAK1BP1,
FAM208B,
RSBN1,
MBNL2,
LRRC16A,
LARP1B,
ARL6IP4,
KAZN,
SEL1L3,
ZNF776,
INTS3,
ZNF57,
ZNF518A,
ZNF787,
PLAG1,
IQSEC1,
SUMO4,
SFRP4,
HIST2H2AA3,
XAF1,
OTUD7B,
RALGAPA1,
THOC7,
DESI1,
JADE1,
PPP4R3A,
SPOPL,
ADNP2,
NIPBL,
RGS7BP,
TENM4,
ZNF280D,
FAM53A,
TIGD7,
DPY19L2,
JMJD6,
PTRF,
ZNF529,
TMEM53,
PNCK,
C16orf46,
ZNF585A,
NFRKB,
ALKBH5,
ZNF449,
RSBN1L,
RFWD3,
KLHDC10,
FBXO38,
BRAT1,
ZC3H14,
ATAD2,
SLC30A9,
WDR74,
BRWD3,
SMARCD3,
ANKRD11,
AFTPH,
CRTC3,
PARM1,
ZNF562,
ATF7IP,
RANBP10,
NSMF,
KDM7A,
DTHD1,
BNC2,
RNF111,
NFXL1,
ZNF600,
RNF165,
ZNF621,
TSHZ1,
PHLPP2,
NEK10,
USP31,
USP45,
KCTD1,
CENPU,
TUBA1A,
H2AFV,
RPS27L,
NOL8,
ZNF534,
SUPT6H,
DDX46,
ASRGL1,
DHX30,
ZNF765,
ZNF771,
MCM10,
MAEA,
ZNF627,
ZNF367,
SETX,
ZNF550,
MIER3,
PIWIL4,
DENND4A,
NUFIP2,
DHX29,
COMMD6,
FAM220A,
DCXR,
AKNA,
ARHGAP22,
WAPL,
IRF2BP2,
CPEB2,
BCDIN3D,
NET1,
FGD2,
HUWE1,
ZNF467,
CENPV,
ZSCAN2,
PCGF5,
ZBTB33,
PEG10,
PRUNE,
PABPN1,
MTDH,
MAGI2,
CASZ1,
ALYREF,
CAND1,
TSPYL5,
SGMS1,
JAZF1,
ZSCAN30,
METTL16,
SPATA24,
LONP2,
OSTM1,
NLRC5,
CHD1L,
GPBP1,
TRIM69,
CARM1,
C19orf68,
MEX3D,
DGKH,
CEP57,
RNF130,
ZNF677,
KIF18B,
ZNF573,
ZNF280B,
TDRP,
PPARGC1B,
GATAD2A,
CAMK1D,
MINA,
RBM45,
SIAH1,
AEBP1,
FOXP4,
NOSTRIN,
ZC3H7A,
BBS7,
WWC1,
SLF2,
TP53INP2,
SIRT2,
KLHL7,
DDIAS,
ZC3H3,
SMC5,
CMIP,
YAF2,
EFCAB13,
SRRM1,
SUPV3L1,
ZNF440,
C1orf174,
TRIM22,
THNSL1,
CMTR2,
HACE1,
MICU2,
ZNF101,
XRN1,
MAML2,
ZNF654,
ABI1,
ASPM,
ZFP82,
CCAR2,
ZNF567,
REXO1,
CRIPAK,
MT1M,
ASCC3,
METTL4,
PHTF2,
LCORL,
PNKD,
ZNF808,
ZNF276,
TMEM57,
RPP25L,
COMMD1,
MYCT1,
ZNF655,
ZNF283,
ZNF513,
ZNF615,
ABTB2,
ZNF709,
ZNF557,
JMY,
ZNF565,
EIF1AD,
ZNF610,
ZNF579,
ZBTB38,
ZNF511,
SPC24,
ATAD1,
INO80E,
SERBP1,
HJURP,
NFATC2IP,
ZNF485,
RNF169,
MSANTD4,
TDRD9,
RCBTB1,
ZNF248,
PHC3,
RGS22,
CPEB3,
GLIS3,
DUSP18,
ZNF548,
ZNF555,
APPL2,
KMT2C,
FBXO22,
ZMIZ2,
ZNF397,
FLCN,
NUP37,
BHLHE22,
NUDT10,
DBF4B,
CMAS,
FBXO18,
CASC5,
ZFP28,
NCOA7,
CTCFL,
KIF18A,
RP9,
GADD45GIP1,
WDR48,
GABPB2,
MPLKIP,
UHMK1,
NEIL3,
FAM76A,
OSR1,
ZSCAN18,
SETD6,
ZNF502,
ZNF564,
MDM1,
ZNF596,
NT5C,
PIFO,
FBXO25,
ZNF507,
URGCP,
NEK9,
ZNF675,
SLC2A14,
DDX54,
SSH3,
UTP15,
GEMIN5,
ZNF721,
UBASH3B,
ZNF526,
ZNF384,
GSG2,
ABHD5,
PHF10,
PPP1R13L,
HDAC7,
CEMIP,
PTPMT1,
GATAD1,
NAT14,
UBLCP1,
ZFPM2,
GLMP,
PHIP,
RASSF5,
PRPF31,
PALLD,
ZNF606,
PSPC1,
SYNE2,
PIBF1,
DNAJC9,
PPM1E,
ARNTL2,
KAT6B,
JDP2,
CSRNP3,
AHCTF1,
CHCHD10,
RSPH1,
AQP3,
TRIB2,
H1FX,
TOPBP1,
BAP1,
DCUN1D4,
NR4A3,
NDRG1,
APPBP2,
DYRK2,
GTF3A,
ANP32B,
RAD54L,
ESR2,
TNR,
HDAC2,
PROX1,
CREBBP,
KAT6A,
N4BP2L2,
TAF15,
GGH,
KAT2B,
DDX17,
APBB2,
ERCC4,
UFD1L,
GATA6,
SLC5A5,
FGF13,
FGF14,
SNAPC3,
EMG1,
LPP,
MED12,
HIST1H2AC,
HIST1H2BH,
PTP4A1,
TCEAL3,
FBXO32,
RPL36AL,
L3MBTL2,
UBE2E3,
TEKT1,
ZNF566,
TP53INP1,
RERG,
FUBP1,
NABP1,
ACD,
PBXIP1,
EME1,
ISG20,
RAD51AP1,
UBE2W,
EXOSC8,
CREB3L1,
CHCHD1,
ZNF669,
UPRT,
ZNF689,
OPTN,
R3HDM4,
TMCO6,
OTUB2,
NUDT16,
MBD6,
LGALS12,
SPDL1,
TCEAL4,
FAM120B,
CYFIP2,
ZNF503,
PELI1,
ZBED6CL,
CDCA5,
CPNE2,
OTUB1,
DPH3,
CFAP36,
NUDT11,
RMND5B,
ZNF274,
AURKB,
DCUN1D1,
CDCA7L,
MASTL,
ZNF486,
ZNF764,
PRR11,
SENP5,
ZNF419,
MED30,
NAF1,
HES6,
ZNF625,
AJUBA,
GMCL1,
ZNF845,
ABHD14B,
NSL1,
PAWR,
RSRC1,
ITCH,
HIC2,
EAF1,
MAML3,
ZNF333,
ZNF462,
CHAMP1,
L3MBTL3,
LCOR,
ZFP91,
PDLIM2,
RITA1,
ZBTB45,
ZNF521,
PBK,
FAM71F1,
SCYL1,
ZNF512B,
EHMT2,
PRMT6,
IFT74,
C9orf72,
RNPC3,
PRIMPOL,
CARD19,
ZSCAN31,
PACRG,
PRICKLE1,
YTHDC1,
ZNF75A,
ZNF578,
ZNF641,
FOPNL,
ZNF285,
ZFP3,
ASB16,
NAP1L5,
NECAB3,
ZNF317,
UHRF2,
NEDD4L,
QKI,
FAM193B,
NEK1,
PUS7,
SMG1,
KIF20B,
DLC1,
PPP1R10,
RAB3IP,
ACRC,
PURB,
PHF12,
SPAG5,
ZNF300,
PASK,
CIC,
CITED4,
MED15,
ERGIC2,
NUDCD1,
USP28,
TRIB3,
TRIB1,
TP53RK,
RANBP9,
CSRNP1,
CCNL2,
SRPK1,
SMC6,
ZNF347,
STRBP,
ZNF607,
ZNF587,
ATOH8,
ZNF382,
RSF1,
SPEN,
SETDB2,
UHRF1,
FAM129B,
TCF12,
MYCBP,
NAP1L3,
CDC5L,
PFDN5,
GPER1,
PLIN2,
MPHOSPH8,
TSC22D3,
MNT,
S100A13,
SCAF11,
KLF6,
PHB2,
COPS8,
PRPF18,
RAD9A,
CHP1,
KIF2C,
MEIS3,
PITX2,
DOK1,
SMAD5,
BARD1,
HNRNPAB,
NAP1L4,
CDC6,
NPAS2,
MDFI,
ACO2,
CIB1,
EBNA1BP2,
ARID3A,
PRMT1,
DUSP9,
PKP2,
CITED1,
CITED2,
VRK1,
GDF15,
NCAPG,
HOPX,
MAPKAP1,
NABP2,
TREX2,
ELAC2,
MACROD1,
TCF25,
MYBBP1A,
SLF1,
ZNF559,
BUD13,
LARP6,
UQCC2,
PELO,
RHNO1,
ZNF2,
TACO1,
FAM64A,
MARVELD1,
INPP5K,
WAC,
DIDO1,
PAGR1,
IER2,
ANP32E,
ZNF692,
NDUFAF3,
MKNK1,
TUBB6,
POLR3C,
HNRNPUL1,
HTATIP2,
DDX23,
FAM195A,
ZNF426,
DUSP26,
ADI1,
RNF126,
MECR,
SNRNP25,
KATNB1,
TUBB2B,
DUSP23,
GNL3,
TIPIN,
KIFC1,
KATNAL1,
HIRIP3,
ACAT2,
REPIN1,
RBM4,
SSBP4,
FUNDC2,
SF3B5,
CDCA7,
PAPOLG,
MND1,
CDK19,
SSBP3,
RBM24,
SORBS1,
SALL3,
NAA15,
CDCA4,
PINK1,
NUSAP1,
TEX15,
OSBPL1A,
FANCD2,
BEX2,
SCAPER,
HDAC8,
RTFDC1,
DUSP16,
PARD6B,
NFKBIZ,
BACH2,
WHSC1L1,
NUF2,
PUS3,
UACA,
DPH1,
WDR11,
TBL1XR1,
PRKD2,
FOXP3,
UBXN6,
NMES1,
TRIM6,
INO80B,
FTO,
ZNF518B,
ZNF407,
STRADB,
POLR2J2,
ACTR6,
PITHD1,
POLR1E,
SLIRP,
NIF3L1,
PEG3,
CTDSP1,
ZNF350,
UBA5,
COMMD4,
USP44,
RNF38,
RACGAP1,
SIK2,
WWP1,
ZNF700,
C11orf54,
RBM38,
DNTTIP1,
CSRNP2,
NUCKS1,
ASCC2,
UPF3A,
CDT1,
EHD4,
SH3BGRL3,
TRIOBP,
EPC1,
TSPYL2,
BLZF1,
PDCL3,
TNKS2,
IKZF4,
DHX36,
HIPK2,
FOXP1,
TXNIP,
CENPH,
DSN1,
CHMP4B,
DEF6,
SENP3,
RGCC,
ZNF335,
DUSP21,
C11orf1,
IKZF5,
FAM96A,
OBFC1,
SOX17,
ARMC7,
YTHDC2,
ESRP2,
EGLN3,
ZNF552,
METTL17,
SUDS3,
TLE6,
PHAX,
METTL8,
RMND5A,
CSRP2BP,
ZNF430,
ZNF395,
ECT2,
HN1L,
MRPL44,
AKIRIN1,
LIN28A,
SAP30L,
EBF2,
SMURF2,
UPF2,
GRPEL1,
CLK4,
BCL2L12,
PLEKHA2,
SP110,
RRAGC,
FANCE,
PATZ1,
BEX1,
MKNK2,
SPC25,
ZNF287,
SLC25A19,
GPBP1L1,
ZBTB20,
NEK6,
HES4,
ZNF532,
METTL14,
ZNF160,
MAGEE1,
RAVER2,
AGO4,
CHD8,
CSNK1G1,
TCF7L1,
POLD4,
ZNF334,
SRA1,
SEPSECS,
RANGRF,
RETN,
HMG20A,
MYOZ1,
MID1IP1,
PARD6A,
MYNN,
EXOSC4,
UBE2T,
NGRN,
NOP10,
BRD7,
ACOT13,
PNRC2,
MED4,
MRPL40,
PLCB1,
HEYL,
TCF7L2,
HINT3,
RRAGD,
PFDN4,
KMT5A,
EXOSC3,
PRDM10,
PRDM6,
ZNF331,
ZNF71,
ZNF302,
PDLIM7,
POLE4,
ASH1L,
MBNL1,
SLC2A4RG,
PDGFC,
EIF4ENIF1,
TSHZ2,
SH2B1,
POLE3,
ZNF277,
LATS2,
UBQLN4,
DUSP22,
INIP,
HELLS,
GLRX2,
RASSF1,
RAD18,
BRWD1,
SAMSN1,
DIAPH3,
BMP2K,
PDS5B,
SMC4,
ZFP64,
RNF146,
MDN1,
MBNL3,
DDX28,
UFSP2,
TDP1,
POT1,
DCAF13,
MED17,
GNL3L,
ARMC1,
SDAD1,
TMEM38B,
THAP1,
RLIM,
ZNF358,
RBM22,
RBFOX1,
RNF216,
SLTM,
AURKAIP1,
HCFC1R1,
UCKL1,
GEMIN8,
TRNAU1AP,
LYAR,
ZDHHC7,
ING3,
ZNF586,
GAR1,
AATF,
SPHK1,
DACT1,
BCLAF1,
ZAK,
DONSON,
MIS18A,
ZNF226,
CDK12,
RRN3,
RBAK,
PRR13,
FAM120A,
EHF,
GPRC5B,
IL37,
GRHL1,
DTL,
ZNF224,
MAT2B,
EHD3,
DNAJC27,
LMCD1,
CWC15,
THYN1,
CRIPT,
CCDC59,
ZKSCAN7,
AKAP7,
SH3BP4,
ZBTB4,
ZNF492,
MBD5,
USP36,
PAK7,
BCCIP,
CHD7,
ZNFX1,
RCOR3,
MYEF2,
KANSL3,
HECW2,
STARD9,
RERE,
THEG,
PSMC3IP,
NFKBIL1,
DNMT3B,
SAE1,
NLK,
HECA,
PPARGC1A,
UXT,
ASH2L,
HDAC6,
SPAST,
EIF3K,
RNF14,
POLK,
NXF1,
SLC25A10,
LRWD1,
ZRANB1,
TES,
KDM5B,
PARP2,
LIMD1,
ZC3H7B,
TCF20,
APOBEC3B,
MLX,
MLH3,
TRPS1,
DCDC2,
IP6K2,
DDX20,
NUFIP1,
USP25,
SAP30BP,
DACH1,
ZNF639,
ZNF230,
TEKT2,
MUTYH,
KLF15,
CNOT7,
PLXNA1,
TSPYL4,
MCM8,
MOSPD1,
ZFP69B,
ERRFI1,
ZNF112,
PURG,
ANAPC5,
ANAPC4,
ZNF222,
ZNF580,
NOCT,
CCNL1,
FEM1B,
HN1,
MRTO4,
TNIK,
TLK1,
NUDT5,
FBXO5,
HDAC9,
AMFR,
AGO2,
ELF5,
ZHX1,
BAG5,
ZNF236,
TCFL5,
TAOK2,
MYT1L,
MTUS1,
MKL2,
ZBTB21,
CNOT6,
PPM1H,
CIZ1,
TPX2,
NAP1L2,
MAFF,
TP53TG3,
PYCARD,
PADI4,
MYO6,
PLAGL1,
KMT2B,
NFU1,
PRPF19,
PHTF1,
SYNPO2,
SUFU,
BOK,
NENF,
NOL7,
SCML1,
POLI,
CDC14A,
SNX6,
ANGEL1,
FAF1,
PPIE,
DIMT1,
TIMELESS,
NOVA2,
WDR3,
NSFL1C,
TRIM33,
TRIM35,
SMG5,
TRAK1,
FOXJ3,
AGTPBP1,
DICER1,
PA2G4,
EXO1,
CDK11A,
SMC3,
MAPK8IP1,
HDAC5,
SCML2,
NIP7,
RUVBL2,
CDYL,
TCF19,
POMP,
HPSE,
RNF6,
RUVBL1,
RASD1,
VDAC3,
INVS,
ASF1A,
PKIG,
SSX2IP,
BTBD3,
MYRF,
R3HDM2,
KDM2A,
FAN1,
PTPN22,
DDX52,
CRYL1,
POLDIP2,
KLHDC2,
THRAP3,
MED16,
KLF13,
SUGT1,
DERA,
SBDS,
REXO2,
TPRKB,
FAM96B,
HDGFRP3,
RTCB,
ZNF337,
TSC22D4,
NOC2L,
SAMHD1,
C2CD2,
PKP3,
KNSTRN,
L3MBTL1,
MTF2,
JRKL,
TRRAP,
NFE2L3,
ZNF451,
USP15,
LOXL2,
LSM5,
RNF114,
CSDC2,
HES2,
ASB3,
NUB1,
YTHDF2,
PAXBP1,
SUPT16H,
PCDHA2,
UTP18,
HEY1,
UCHL5,
ORC6,
MAFB,
RBM8A,
ZNF706,
KLF2,
HCFC2,
FHOD1,
IRAK3,
NCOR2,
RAD54B,
GPC6,
SPIN1,
EID1,
MAD1L1,
STK24,
COMMD10,
CHCHD2,
CABIN1,
IGF2BP2,
CSNK1G3,
SESN1,
NCOA3,
DUSP10,
CAMTA1
|
|
GO:0005635
|
CC
|
nuclear envelope
|
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
NEMP2,
HAX1,
CLIC1,
BIN1,
TOR1A,
MGST3,
CLGN,
XPO1,
NPC1,
PGRMC2,
NUPL2,
CHMP2A,
BNIP3L,
NUP155,
CTDNEP1,
LMNA,
CYBB,
S100A6,
PARP1,
POLA1,
ALOX5,
TPR,
RAC2,
ATF6,
LMNB1,
RRM1,
MAPK3,
CLIP1,
SREBF1,
NUP62,
TMPO,
TMPO,
PTGER3,
RANBP1,
CBX5,
RANGAP1,
CENPF,
PCYT1A,
RANBP2,
EMD,
ANXA11,
IST1,
CSE1L,
SEC13,
NUP107,
UBE2I,
RAE1,
NUCB2,
DST,
TYRO3,
BAX,
NUP160,
RAB40B,
LRMP,
BNIP3,
AKAP6,
CBX3,
MTA1,
KCNJ11,
LPIN1,
KPNB1,
EBP,
NSMF,
NUP93,
CNEP1R1,
ABCF1,
MNS1,
NUP43,
NUP37,
NUP35,
NUP210,
TMEM170A,
SYNE2,
NUP205,
SLC22A18,
SEH1L,
GMCL1,
IPO9,
GPER1,
SIGMAR1,
MGST2,
NDC1,
HTATIP2,
NUP58,
NUP85,
NDEL1,
TNKS2,
CHMP4B,
SPAG4,
RTN4,
PARP11,
AGPAT3,
SUN2,
FAF1,
PLA2G4C,
RTCB
|
|
GO:0005637
|
CC
|
nuclear inner membrane
|
The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.
|
TMEM120B,
NEMP2,
ERN1,
LMNB1,
IFI27,
TMPO,
TMPO,
LRPPRC,
MATR3,
PSEN2,
EMD,
TRA2B,
SMAD3,
LMNB2,
CBX3,
ITPR1,
SMAD1,
DPY19L2,
DPY19L3,
DPY19L4,
SIGMAR1,
TMEM120A,
ATP11B,
LEMD3
|
|
GO:0005638
|
CC
|
lamin filament
|
Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C.
|
LMNA,
LMNB1,
LMNB2
|
|
GO:0005639
|
CC
|
integral component of nuclear inner membrane
|
The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
P2RX4,
TMEM43,
SUN2,
LEMD3
|
|
GO:0005640
|
CC
|
nuclear outer membrane
|
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
|
SNCA,
LRPPRC,
PSEN1,
EMD,
NUTF2,
GUCY2D,
DMPK,
ITPR3,
SYNE2,
SIGMAR1,
DHCR7
|
|
GO:0005641
|
CC
|
nuclear envelope lumen
|
The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide.
|
PTGES,
APP,
TUBB,
ALOX5,
IGF2R,
SORL1,
CACYBP
|
|
GO:0005642
|
CC
|
annulate lamellae
|
Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER.
|
XPO1,
NUP62,
EIF5A
|
|
GO:0005643
|
CC
|
nuclear pore
|
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
|
MYO1C,
IPO5,
KPNA3,
KPNA4,
KPNA5,
NUPL2,
TNKS,
TPR,
NUP62,
RANGAP1,
NUP153,
RANBP2,
KPNA2,
KPNA1,
AGFG1,
NUP107,
EIF5A,
RAE1,
NUP160,
MAD2L1,
KPNB1,
NUP93,
NUP210,
IPO4,
AHCTF1,
NUP205,
NUP88,
PIK3R4,
NDC1,
NUP58,
XPO4,
EIF5A2,
ENY2,
PARP11,
NXF1,
NXT1,
NUP50,
NPIPA1,
MAD1L1
|
|
GO:0005652
|
CC
|
nuclear lamina
|
The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane.
|
CASK,
NUP35
|
|
GO:0005654
|
CC
|
nucleoplasm
|
That part of the nuclear content other than the chromosomes or the nucleolus.
|
PTPDC1,
STRA13,
DDX39A,
ACOT7,
MYO1C,
SNAP23,
EYA2,
AIP,
APBB1,
PSMD11,
PSMD12,
SUPT5H,
DFFA,
CDC7,
ARNTL,
IPO5,
SAP18,
RTCA,
GOLIM4,
ELL2,
NR5A2,
KPNA3,
VWA5A,
NOP56,
KPNA4,
UBE2C,
PDXK,
ARID1A,
COPE,
CTDSP2,
UTY,
AP3D1,
CHD2,
ENC1,
CHEK1,
TFEC,
AURKA,
PPP1R12A,
HNRNPDL,
XPO1,
BTAF1,
U2SURP,
ANKRD28,
SMAD7,
SCAMP1,
SCAMP2,
KPNA5,
MDM4,
POLR1C,
SMAD9,
FANCG,
OGT,
SIVA1,
POLR3G,
PPM1G,
SOX12,
HDAC3,
BIRC5,
CD3EAP,
NUPL2,
POLR2D,
MAFG,
KDM6A,
ADAM12,
PSMD3,
RBFOX2,
SIAH2,
AP5Z1,
PAX4,
HOXA2,
HOXA3,
HNRNPR,
PRPF3,
PPIH,
KLF4,
OIP5,
RAD51C,
MED7,
FOXO3,
SPRY1,
PLRG1,
PRC1,
BUB1,
BUB3,
ENSA,
NUDT21,
ORC5,
RAD21,
DHX16,
PPP1R12B,
MED14,
SMARCA5,
NUAK1,
OPA1,
KDM1A,
HBP1,
SYNCRIP,
CCNT1,
CCNT2,
RAD1,
REV3L,
JAK2,
UGDH,
CDC14B,
HIST1H2BK,
PQBP1,
DKC1,
BRD4,
TBL1X,
NBN,
MITF,
FAM20B,
ZC3H11A,
RAB11FIP3,
SIN3B,
DNAJB6,
NDUFS2,
ZPR1,
ZNF217,
NCOR1,
PRPF40A,
POLQ,
PSIP1,
SUPT3H,
SRSF10,
GMNN,
HSBP1,
ECI2,
KHDRBS3,
TADA3,
BANF1,
SKAP2,
PRKRA,
CRCP,
RPS6KA5,
MED6,
USP2,
TRMU,
UTP20,
WDHD1,
RAD51D,
RNASEH2A,
POP7,
RPP40,
PSMD10,
STAM2,
TNFSF13,
ATP5H,
CLPX,
RNF8,
USP1,
TOX4,
UBXN7,
NFAT5,
KDM4B,
CEP152,
HEXIM1,
CCNB2,
UBR5,
FSBP,
SCAF4,
NDUFB6,
NDUFB4,
ZRANB2,
LUC7L3,
KIF20A,
KIF4A,
MBD4,
SMC2,
GDF11,
CD2BP2,
PSMG1,
ETHE1,
POLR1A,
YEATS4,
STAMBP,
NFATC1,
POP4,
LSM8,
ZMYM6,
CBX7,
MBD3,
TOMM40,
ACTL6A,
CCNE2,
WHSC1,
DHFR,
FOS,
MYC,
CRYAB,
LMNA,
ESR1,
ANXA1,
NR3C1,
TP53,
TYMS,
GNAI2,
ISG15,
JUN,
PRKCB,
KRT8,
UROD,
RB1,
PGR,
PTMA,
CDK1,
GPI,
NPM1,
APRT,
HSP90AA1,
HNRNPC,
ERCC1,
NGFR,
HSP90AB1,
RPS17,
RPSA,
SNRPA,
SNRPC,
HMGB1,
RBP1,
CNP,
DLD,
HNRNPA1,
SNRPA1,
PARP1,
POLA1,
UCHL1,
UBC,
HSPA1A,
HSPA1B,
GLI2,
GLI3,
MYBL2,
AR,
NR2F1,
TXN,
THRA,
IRF1,
PDHB,
TOP1,
TOP2A,
VDR,
ESRRA,
CDK4,
PCNA,
TPR,
PTHLH,
SKI,
SKIL,
XRCC5,
UNG,
RNH1,
GTF2F2,
HSD17B1,
MIF,
FDPS,
CCNB1,
SNRPB,
IDE,
POU2F1,
HNRNPL,
ETS1,
ETS2,
AKR1B1,
FOSL2,
HPGD,
RPS2,
RAG1,
TCF3,
NQO2,
H2AFX,
CREB1,
GCFC2,
ZNF12,
ZNF22,
HMGA1,
PRKCA,
JUNB,
UBTF,
ATF7,
PRKACA,
CEBPB,
PTPN2,
DDX5,
XBP1,
PSMC3,
ERCC2,
EGR1,
SON,
RCC1,
ATF1,
ATF3,
ATF4,
ATF6,
LIG1,
POLR2E,
ELK1,
NFKB1,
CCNA2,
NR1D1,
MSH3,
PSMB1,
LMNB1,
BCL3,
FGFR2,
SDHB,
OSBP,
RPS4Y1,
SCP2,
HNRNPA2B1,
UQCRC2,
NR4A1,
XPA,
SFPQ,
SP100,
RRM1,
GADD45A,
POLR2A,
CDK2,
APC,
PTAFR,
MCM3,
NFYB,
DNAJB1,
PSMA1,
PSMA2,
PSMA3,
PSMA4,
DNMT1,
CHML,
HMGB2,
PTBP1,
MAPK3,
ARNT,
CAD,
PSMB8,
PSMB9,
PSMB4,
PSMB5,
POLD1,
MAPK1,
RXRB,
RBL1,
LAP3,
MPG,
KDM5A,
TKT,
BLVRB,
CDC27,
CCND2,
CCND3,
WEE1,
CDC25A,
CDC25B,
CDC25C,
SRI,
ALDH1B1,
POLR2B,
RRM2,
TIA1,
HIVEP2,
AKT1,
AKT2,
HNRNPH3,
HNRNPH1,
GTF2H1,
DUT,
HIST1H2BB,
MCM4,
MCM5,
MCM7,
HSPA1L,
CTNNB1,
PHB,
RPA3,
RFC4,
RFC2,
GTF2F1,
HRH1,
RORA,
FUS,
DDIT3,
DEK,
SOX6,
AHR,
PSMC2,
POLR2I,
SREBF1,
PPARG,
ZEB1,
RBMX,
BRCA1,
COIL,
CDKN1A,
ANP32A,
FEN1,
CAPG,
PSMB10,
PBX1,
MLH1,
STAT3,
MDH2,
RFC5,
RFC3,
ID1,
ETV5,
BCL6,
UBA7,
ELK3,
STAT5A,
SKIV2L2,
RPS27,
NCAPD3,
LRPPRC,
CDKN2B,
HTT,
MATR3,
MSH2,
NR4A2,
NAMPT,
PSMC4,
GATA4,
NKX2-1,
CBX5,
MAPK8,
MAPK9,
RECQL,
CDKN1B,
NOTCH1,
BRCC3,
RPS9,
RPS5,
RPS10,
YAP1,
SOX9,
NRIP1,
CSNK1D,
MAPKAPK2,
NASP,
CDK8,
CDC34,
CENPA,
CENPF,
PRIM1,
PRIM2,
CSNK1E,
PSMB3,
MCM2,
RBM25,
CLK2,
NUP153,
RGS3,
MRE11A,
HNMT,
ERF,
CDK7,
CCT8,
ANXA11,
PAPOLA,
DAP3,
DUSP3,
DNA2,
SMARCA2,
SMARCA4,
BRCA2,
PSMD7,
STAT5B,
AFF3,
NR0B1,
HDGF,
CCNG1,
UBE2E1,
HNRNPA3,
HNRNPM,
KPNA2,
KPNA1,
POLR2J,
MAP2K6,
STAT2,
GTF2A1,
GTF2A2,
MSH6,
RBM5,
HMGA2,
PLK1,
CEBPG,
POLR2K,
SMTN,
BLM,
RARS,
HIRA,
ATXN3,
ATXN1,
ATN1,
TERF1,
PRKAG1,
PRKAA2,
RAD23B,
NR1H2,
CSE1L,
VCP,
MLLT10,
CASP6,
SEC13,
SNU13,
HNRNPH2,
SUMO3,
EIF3B,
NDUFV3,
ARPP19,
POLE2,
HDAC4,
EIF6,
PEX3,
GEMIN4,
NUP107,
YBEY,
TIRAP,
HIST1H2BD,
PTEN,
PPP4C,
ACTB,
RPS20,
CKS1B,
UBE2D3,
RPS3A,
PSME3,
STXBP1,
SUMO2,
DCAF7,
NUTF2,
RPS7,
PPP1CA,
PPP1CB,
CALM2,
PSMC1,
RPS8,
RPS15A,
RPS16,
RPS14,
RPS18,
RPS13,
RPS11,
SNRPF,
LSM3,
LSM6,
SNRPD1,
SNRPD2,
SNRPD3,
PSMC6,
POLR2G,
RPS6,
HIST1H4A,
HIST1H2BC,
RPS25,
RPS26,
POLR2L,
RBX1,
RPS27A,
UBA52,
GRB2,
TRA2B,
YWHAZ,
UBE2B,
SKP1,
RPS21,
UBE2I,
YBX1,
HIST1H3D,
CXADR,
RPP30,
GTF2I,
PIP4K2B,
SRPK2,
OLR1,
CCNA1,
PRKDC,
NTHL1,
ADARB1,
SARNP,
CBX1,
SMAD3,
H3F3A,
XIAP,
FOXO4,
RBM3,
GTF2B,
CDK6,
CDK5,
HSF1,
HNRNPU,
IRF9,
MDM2,
E2F1,
INSM1,
SET,
SRSF2,
RUNX1,
RELB,
FABP5,
HMGCS1,
SATB1,
XPC,
POU5F1,
MEF2A,
DHODH,
KIF23,
ALDH6A1,
ID2,
SP3,
ID3,
FKBP4,
PPARD,
CENPC,
RELA,
NOTCH2,
TLE1,
TLE3,
REL,
SRSF11,
PRKCD,
EXOSC9,
MEF2C,
GABPA,
RING1,
RAD51,
PAX8,
FMR1,
SOX4,
KHDRBS1,
MCL1,
POLE,
PPARA,
SRSF1,
FOXM1,
PPP3CA,
PPID,
SSRP1,
NSUN2,
RBBP4,
NCBP1,
EP300,
SMAGP,
FAAP100,
CPSF1,
TMEM94,
SREBF2,
ARHGEF5,
FOXO1,
TBL3,
CDC20,
SF3A3,
ILF2,
ILF3,
FOXC1,
TAF10,
BNIP3,
CSTF3,
STRN3,
COASY,
ZBTB17,
CHAF1B,
NR1H3,
TARDBP,
MAPK7,
PAK2,
CBLB,
PSMD2,
GPS2,
SRSF9,
SRSF5,
SRSF6,
TRIM28,
NMI,
SKP2,
MTA1,
ITGB3BP,
PPIL2,
PPP2R5C,
ORC1,
ILK,
XRCC4,
PPIG,
GOLGA4,
FKBP5,
NFATC2,
SMAD4,
BIRC3,
SQSTM1,
PRPF4B,
EIF4EBP1,
HDAC1,
CAMK2D,
TDG,
DGKZ,
CUL2,
CUL3,
CUL4A,
CUL4B,
TP53BP2,
EXOSC2,
KLF9,
GTF2H2,
C1D,
CUX1,
RUNX2,
NFYC,
CDK13,
CIRBP,
HNRNPD,
DAG1,
VEZF1,
BOP1,
MORC3,
SPIDR,
GIT2,
POLA2,
TFDP1,
SIM2,
ZMYM3,
NPAT,
E2F2,
TRIM25,
FAM50A,
HES1,
SLBP,
RBM39,
MCM6,
ITPR3,
MDC1,
SMC1A,
GINS1,
LPIN1,
PPP2R5D,
CASP8,
MEF2D,
CHD4,
ARID5B,
MTF1,
ZNF638,
KPNB1,
NR1D2,
CUL7,
NAA25,
KIAA0101,
WTAP,
MORF4L2,
SART3,
NCAPD2,
SUZ12,
EXOSC7,
POLD3,
ACOX1,
TCEAL1,
PTGES3,
NONO,
PPP2R4,
RNPS1,
RBBP5,
ERBB4,
ZMYND11,
ANKRD1,
RPS6KA2,
PCBP1,
TCEB1,
TCEB2,
PUM3,
RPS6KA1,
NR0B2,
RGN,
TAF5,
TAF11,
TEAD4,
TEAD2,
TAF1C,
TAF1A,
NCOA2,
TRIP10,
JMJD1C,
ELAVL1,
TAB1,
NCOA1,
SMAD2,
SMAD1,
UBE2V2,
STK11,
ADIRF,
USF2,
EZH2,
ZFHX3,
ZIC1,
ADRM1,
UAP1,
PKN1,
PKN2,
TAF12,
SNAPC1,
MAPK14,
SNRNP35,
HIF1A,
IFI16,
ZSCAN26,
DUSP5,
DECR1,
KYNU,
HIST2H2BE,
DUSP6,
DUSP7,
HADH,
PFKFB3,
FAM110C,
PDS5A,
ERCC6L,
TSR1,
QRICH1,
CHD9,
TIMM50,
GLYR1,
ZBED5,
LARP7,
ARID4B,
FLYWCH1,
LIN52,
FAM98B,
PDCD4,
C11orf73,
IFI44L,
CDCA8,
SMUG1,
TAF1B,
SGOL2,
ESCO2,
ZNF326,
CMPK2,
CENPW,
SGOL1,
BCORL1,
HABP4,
EXOSC6,
RBM48,
ZC3H13,
ARMC4,
UBR4,
PHF19,
ACBD5,
CPSF3L,
DEPDC1,
RSPH4A,
RIF1,
FAM208B,
ICE2,
SEL1L3,
MSL1,
INTS3,
CDCA2,
THOC7,
JADE1,
NIPBL,
PWWP2B,
JMJD6,
FAAP20,
PTRF,
MIS18BP1,
TATDN1,
C16orf46,
NFRKB,
RFWD3,
PPIP5K1,
SHQ1,
CCDC174,
ZC3H14,
LARP1,
ATAD2,
AGTRAP,
SMARCD3,
ANKRD12,
ANKRD11,
AFTPH,
FIP1L1,
CRTC3,
ATF7IP,
RAD9B,
NSMF,
CYHR1,
KDM7A,
RNF111,
USP45,
CENPU,
RPS27L,
ASXL2,
CENPQ,
MCM10,
COPS6,
EPM2AIP1,
RAB11FIP2,
CXXC5,
ZNF367,
PID1,
SETX,
HAUS6,
EMSY,
WAPL,
SPRED1,
CCDC91,
RBBP6,
HUWE1,
CENPV,
ZBTB33,
SYVN1,
PABPN1,
PBRM1,
USP48,
CASZ1,
ALYREF,
CAND1,
SPATA24,
SLC26A11,
CHD1L,
GPBP1,
RPS19BP1,
CARM1,
NCAPG2,
CEP57,
KMT5C,
PPARGC1B,
GATAD2A,
DCP2,
CREBRF,
NAV2,
MGA,
ZBTB8OS,
SUGP2,
CCAR1,
BAP18,
KLHL7,
SMC5,
DHX37,
YAF2,
EFCAB13,
SRRM1,
FANCM,
TRIM22,
THNSL1,
PM20D2,
ZBED8,
KMT2E,
MAML2,
CMTM8,
CENPL,
EID3,
CCAR2,
INTS1,
APITD1,
ASCC3,
MPP5,
FNBP4,
TAB3,
NKAP,
COMMD1,
EID2,
KIAA1958,
ABTB2,
JMY,
BANP,
EIF1AD,
ATG16L2,
FANCB,
HJURP,
ZBTB34,
RNF169,
TNRC6A,
PHC3,
SETD9,
ABCF1,
GLIS3,
DUSP18,
MCPH1,
VPS37A,
KMT2C,
ZMIZ2,
BOD1L1,
ARID1B,
NUP37,
NUP35,
DBF4B,
CMAS,
CASC5,
NEK11,
CEP70,
MFSD8,
THOC2,
WDR36,
MPLKIP,
SMARCC2,
ZNF420,
NEIL3,
ZCRB1,
TRPM4,
HELQ,
NEK7,
MORC4,
DCAF11,
SH3RF2,
UTP15,
GEMIN5,
SMCR8,
PNISR,
SETD7,
FAM222B,
PPIL4,
GTF3C2,
PPP1R13L,
HDAC7,
GATAD1,
CHTF18,
SNRNP27,
TSEN15,
ZFPM2,
SLC44A1,
PRPF31,
SREK1,
GEMIN6,
ATRIP,
PSPC1,
SYNE2,
BBX,
KAT6B,
AHCTF1,
KCTD13,
RFFL,
TOPBP1,
BAP1,
NR4A3,
HSPH1,
NUP205,
ANKS1A,
DYRK2,
GTF3A,
RAD54L,
ESR2,
TNR,
GTF2H4,
HDAC2,
CREBBP,
KAT6A,
SYMPK,
EZH1,
TAF15,
KAT2B,
DDX17,
RAD50,
ERCC4,
UFD1L,
GATA6,
SMARCC1,
KHSRP,
SNAPC3,
EMG1,
ATP6V0A1,
RBPMS,
MED12,
HIST1H2BH,
POP5,
FBXO32,
L3MBTL2,
ITFG2,
PMEPA1,
UTP4,
TP53INP1,
FUBP1,
NABP1,
CLUAP1,
ACD,
EME1,
ISG20,
RAD51AP1,
EXOSC8,
TADA1,
SYTL4,
OPTN,
NUDT16,
ANAPC16,
SNRNP40,
MBD6,
ZBTB10,
ELP4,
DAZAP1,
MVB12A,
NRBF2,
CDCA5,
DPH3,
AURKB,
MASTL,
LIN37,
CENPN,
TONSL,
SENP5,
CDKN2AIPNL,
MED30,
INTS4,
THOC3,
EAF1,
MAML3,
CHAMP1,
FEM1C,
EHMT2,
ZFR,
PRMT6,
C9orf72,
RNPC3,
HS6ST2,
NOL4L,
ZNF641,
SPATA13,
TOX2,
RPRD1A,
UHRF2,
NEDD4L,
FAM193B,
TRNT1,
KIF20B,
PPP1R10,
PHF12,
MAGI1,
SPAG5,
SNX18,
NR1H4,
MED15,
USP28,
TRIB3,
TP53RK,
CCNL2,
SMC6,
DCLRE1C,
VWA9,
SECISBP2,
RSF1,
RBM15,
SPEN,
SETDB2,
FAM129B,
YME1L1,
CDC5L,
NUP88,
SCAF11,
TEAD3,
TIMM17A,
DNAJC7,
COPS8,
RAD9A,
PKMYT1,
MGLL,
SMAD5,
BARD1,
HNRNPAB,
LITAF,
CDC6,
NPAS2,
EPAS1,
CIB1,
ARID3A,
PRMT1,
PKP2,
VRK1,
MAPKAP1,
NABP2,
ELAC2,
MYBBP1A,
PYGO2,
GINS4,
GINS3,
CENPK,
RHNO1,
POLR3GL,
WAC,
DCTN5,
IER2,
CENPO,
MKNK1,
POLR3C,
HNRNPUL1,
RPP25,
MENT,
HTATIP2,
DDX23,
SNRNP25,
DSCC1,
MLST8,
PHF20,
GNL3,
TIPIN,
RBM4,
SF3B5,
CDCA7,
PAPOLG,
SORBS1,
TM2D1,
CLEC7A,
OSBPL1A,
FANCD2,
HDAC8,
POLDIP3,
DUSP16,
NIFK,
HELZ2,
MRPS26,
WHSC1L1,
ASPSCR1,
TBL1XR1,
PRKD2,
TRIM8,
LRRCC1,
XPO4,
ZNF436,
WDR12,
SENP6,
POLR1E,
PEG3,
CTDSP1,
ZNF350,
RNF38,
RACGAP1,
CCDC113,
DDX47,
DNTTIP1,
BCL11A,
ANAPC1,
POLR3F,
ASCC2,
UPF3A,
CDT1,
EPC1,
TSPYL2,
BLZF1,
IKZF4,
HIPK2,
PNN,
FOXP1,
KCTD10,
CENPH,
SENP3,
SMARCAD1,
PCIF1,
C11orf1,
SUV39H2,
TAF1D,
FAM96A,
OBFC1,
SOX17,
ESRP2,
EGLN3,
SMYD3,
WDR26,
METTL17,
SUDS3,
PHAX,
UBE2Z,
NOL11,
MED20,
AKIRIN1,
COPS7B,
MEAF6,
SAP30L,
PLEKHA5,
SMURF2,
CACYBP,
FANCE,
RC3H2,
PATZ1,
MKNK2,
VEZT,
TAF9B,
ETNK1,
ZBTB20,
NEK6,
METTL14,
CWC22,
CHD8,
TCF7L1,
POLD4,
SRA1,
RANGRF,
EXOSC4,
UBE2T,
NOP10,
BRD7,
MED4,
TIMMDC1,
AKIP1,
HEYL,
ANO2,
TCF7L2,
KMT5A,
EXOSC3,
ANLN,
ACSS2,
ASH1L,
MBNL1,
SLC2A4RG,
INIP,
GLRX2,
RAD18,
CENPM,
BMP2K,
PDS5B,
SMC4,
POT1,
DCAF13,
MED17,
INTS7,
FANCI,
ASF1B,
INTS10,
RLIM,
HAUS2,
POLR3B,
RBM22,
ARGLU1,
SLTM,
PARPBP,
PAK1IP1,
AURKAIP1,
GID8,
HYPK,
SYBU,
ZDHHC7,
ING3,
CDKN2AIP,
NSMCE4A,
GAR1,
DACT1,
BCLAF1,
MIS18A,
CDK12,
RRN3,
GTSE1,
EHF,
GRHL1,
DTL,
LMCD1,
CWC15,
CCDC59,
NDUFA13,
H2AFY2,
HMG20B,
ZNRD1,
FNIP2,
KLHL8,
CPSF2,
MYEF2,
KANSL3,
STARD9,
NFKBIL1,
DNMT3B,
ORC3,
SAE1,
NLK,
PPARGC1A,
ASH2L,
POLK,
DBF4,
MORF4L1,
NXF1,
TJP2,
DNAJB4,
ADD3,
EPHA6,
ZRANB1,
PRKAG3,
KDM5B,
PARP2,
TCF20,
TRPS1,
IP6K2,
DDX20,
BAIAP2L1,
SAP30BP,
PUF60,
ZNF639,
MUTYH,
BAZ1B,
CNOT7,
SERPINB13,
ZMYM5,
MCM8,
TRMT6,
TUBD1,
CDC23,
ANAPC5,
ANAPC4,
GGA1,
NOCT,
LSM7,
FEM1B,
MRTO4,
TNIK,
PITPNC1,
NXT1,
GTF3C4,
FBXO5,
HDAC9,
AGO2,
NUP50,
ZHX1,
INTS6,
BLOC1S6,
ZMIZ1,
TPX2,
NOB1,
MAFF,
PADI4,
FZR1,
ANAPC10,
MYO6,
PLAGL1,
KMT2B,
NFU1,
PRPF19,
SUFU,
NENF,
NDRG2,
POLI,
STUB1,
CDC14A,
PPIE,
DIMT1,
TIMELESS,
WDR3,
NSFL1C,
PLA2G4C,
SCAF8,
TRIM33,
SRRM2,
PA2G4,
EXO1,
SMC3,
HDAC5,
ZNF148,
RUVBL2,
CDYL,
AKT3,
POMP,
GINS2,
HPSE,
RNF6,
POLH,
PRELID1,
RUVBL1,
ASF1A,
BTRC,
KDM2A,
DIS3,
FAN1,
HIF3A,
RCL1,
DDX52,
POLR1D,
THRAP3,
MED16,
POLR3K,
FCF1,
LSM2,
RRP7A,
SBDS,
SF3B6,
FAM96B,
HDGFRP3,
RTCB,
NOC2L,
SAMHD1,
L3MBTL1,
ZNF175,
MTF2,
TRRAP,
LOXL2,
WIPI2,
LAS1L,
LSM5,
LSM4,
SUPT16H,
UTP18,
HEY1,
ORC6,
RBM8A,
HCFC2,
NCOR2,
MRPS18B,
EID1,
STK24,
CABIN1,
NCOA3,
DDX49,
DUSP10,
IVNS1ABP
|
|
GO:0005655
|
CC
|
nucleolar ribonuclease P complex
|
A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.
|
POP7,
RPP40,
POP4,
RPP30,
POP5
|
|
GO:0005656
|
CC
|
nuclear pre-replicative complex
|
A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.
|
ORC3
|
|
GO:0005657
|
CC
|
replication fork
|
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
CHEK1,
RAD51C,
NBN,
RAD51D,
TP53,
PCNA,
H2AFX,
DNMT1,
BCL6,
UBE2B,
UHRF1,
PIF1,
RAD18
|
|
GO:0005658
|
CC
|
alpha DNA polymerase:primase complex
|
A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.
|
POLA1,
MCM3,
POLA2
|
|
GO:0005662
|
CC
|
DNA replication factor A complex
|
A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.
|
PLRG1,
XPA,
RPA3,
PURA,
TONSL,
PURB,
CDC5L,
PRPF19
|
|
GO:0005663
|
CC
|
DNA replication factor C complex
|
A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides.
|
PCNA,
RFC4,
RFC2,
RFC5,
RFC3
|
|
GO:0005664
|
CC
|
nuclear origin of replication recognition complex
|
A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
|
ORC5,
MCM2,
ORC1,
REPIN1,
ORC3,
LRWD1,
ORC6
|
|
GO:0005665
|
CC
|
DNA-directed RNA polymerase II, core complex
|
RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
|
POLR2D,
URI1,
POLR2E,
POLR2A,
POLR2B,
POLR2I,
POLR2J,
POLR2K,
POLR2G,
POLR2L,
POLR2J2,
PPARGC1A
|
|
GO:0005666
|
CC
|
DNA-directed RNA polymerase III complex
|
RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
|
POLR1C,
POLR3G,
CRCP,
POLR2E,
POLR2K,
POLR2L,
POLR3GL,
POLR3C,
POLR3F,
POLR3B,
POLR1D,
POLR3K
|
|
GO:0005667
|
CC
|
transcription factor complex
|
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
E2F8,
PDLIM1,
HAX1,
ARNTL,
MEIS1,
SMAD7,
SMAD9,
MED7,
SMAD6,
LDB2,
KDM1A,
CREG1,
FOS,
JUN,
PARP1,
CDK4,
SKI,
SKIL,
HCLS1,
ETS1,
TCF4,
TCF3,
HMGA1,
JUNB,
JUND,
TAL1,
CDK2,
YY1,
LMO2,
RBL1,
HOXA10,
CTNNB1,
AHR,
ZEB1,
PBX1,
PBX2,
NKX2-1,
YAP1,
SUB1,
LMO4,
PRKDC,
SMAD3,
MEF2A,
POU3F1,
CREM,
RELA,
REL,
EP300,
SMAD4,
RUNX2,
TFDP1,
E2F2,
NFATC4,
ANKRD1,
TEAD2,
SMAD2,
SMAD1,
ZFHX3,
HIF1A,
ATF7IP,
MINA,
ARNTL2,
NR4A3,
GATA6,
HES6,
AJUBA,
PITX2,
SMAD5,
NPAS2,
EPAS1,
NAA15,
SOX17,
BEX1,
TCF7L1,
MED17,
RCOR3,
LIMD1,
TRPS1,
DACH1,
HDAC9,
MAFB,
IVNS1ABP
|
|
GO:0005668
|
CC
|
RNA polymerase transcription factor SL1 complex
|
A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.
|
TAF1B,
TAF1D
|
|
GO:0005669
|
CC
|
transcription factor TFIID complex
|
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
|
EDF1,
TP53,
ERCC1,
TAF10,
TAF5,
TAF11,
TAF12,
ERCC4,
TAF9B
|
|
GO:0005671
|
CC
|
Ada2/Gcn5/Ada3 transcription activator complex
|
A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues.
|
MAP3K7,
TADA3,
DR1,
KAT2B,
SGF29,
CSRP2BP,
POLE4,
POLE3,
YEATS2
|
|
GO:0005672
|
CC
|
transcription factor TFIIA complex
|
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
|
GTF2A1,
GTF2A2,
GTF2A1L
|
|
GO:0005674
|
CC
|
transcription factor TFIIF complex
|
A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation.
|
GTF2F2,
GTF2F1
|
|
GO:0005675
|
CC
|
holo TFIIH complex
|
A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.
|
ERCC2,
GTF2H1,
CDK7,
GTF2H2,
GTF2H4
|
|
GO:0005677
|
CC
|
chromatin silencing complex
|
Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.
|
SMARCA5,
SIRT2
|
|
GO:0005680
|
CC
|
anaphase-promoting complex
|
A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
|
UBE2C,
BUB1B,
CDC27,
CDC20,
CUL7,
UBE2S,
CACUL1,
ANAPC16,
ANAPC1,
CDC23,
ANAPC5,
ANAPC4,
FZR1,
ANAPC10
|
|
GO:0005681
|
CC
|
spliceosomal complex
|
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
|
DDX39A,
HNRNPR,
PRPF3,
PPIH,
DHX16,
LSM8,
HNRNPC,
SNRPA,
HNRNPA1,
SNRPA1,
SNRPB,
LGALS3,
HNRNPA2B1,
HNRNPH3,
BUD31,
RBM25,
HNRNPM,
RBM5,
SNRPF,
LSM6,
SNRPD2,
SNRPD3,
SNRPN,
SRSF2,
SF3A3,
RHEB,
ZNF326,
DHX32,
CCAR2,
SREK1,
RBM17,
PRPF18,
WAC,
CRNKL1,
CWC22,
CWC15,
PTBP2,
TTF2,
SCAF8,
LSM5,
LSM4,
IVNS1ABP
|
|
GO:0005682
|
CC
|
U5 snRNP
|
A ribonucleoprotein complex that contains small nuclear RNA U5.
|
CD2BP2,
SNRPB,
SNRPD1,
SNRPD2,
SNRPD3,
SNRPN,
SNRNP40,
PRPF18,
DDX23
|
|
GO:0005683
|
CC
|
U7 snRNP
|
A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs.
|
SNRPB,
SNRPF,
SNRPD3
|
|
GO:0005684
|
CC
|
U2-type spliceosomal complex
|
Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends.
|
PRPF31,
SF3B6
|
|
GO:0005685
|
CC
|
U1 snRNP
|
A ribonucleoprotein complex that contains small nuclear RNA U1.
|
PRPF40A,
LUC7L3,
SNRPA,
SNRPC,
SNRPB,
SNRPF,
SNRPD1,
SNRPD2,
SNRPD3,
SNRPN,
PRPF39,
LUC7L,
LUC7L2
|
|
GO:0005686
|
CC
|
U2 snRNP
|
A ribonucleoprotein complex that contains small nuclear RNA U2.
|
SNRPA1,
SNRPB,
SNRPD1,
SNRPD2,
SNRPD3,
SNRPN,
SF3B5,
RBMX2,
SF3B6
|
|
GO:0005687
|
CC
|
U4 snRNP
|
A ribonucleoprotein complex that contains small nuclear RNA U4.
|
SNRPB,
SNRPF,
SNRPD1,
SNRPD2,
SNRPD3,
SNRPN,
PRPF31
|
|
GO:0005688
|
CC
|
U6 snRNP
|
A ribonucleoprotein complex that contains small nuclear RNA U6.
|
LSM3,
LSM6,
LSM7,
LSM2,
LSM5,
LSM4
|
|
GO:0005689
|
CC
|
U12-type spliceosomal complex
|
Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site.
|
DHX15,
SNRPB,
SNRPF,
SNRPD1,
SNRPD2,
SNRPD3,
YBX1,
SNRNP35,
ZCRB1,
RNPC3,
SNRNP25,
SF3B5,
LSM7,
SF3B6
|
|
GO:0005690
|
CC
|
U4atac snRNP
|
A ribonucleoprotein complex that contains small nuclear RNA U4atac.
|
PRPF31
|
|
GO:0005691
|
CC
|
U6atac snRNP
|
A ribonucleoprotein complex that contains small nuclear RNA U6atac.
|
SART3
|
|
GO:0005694
|
CC
|
chromosome
|
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
|
GTPBP10,
HMGB3,
CD3EAP,
RAD21,
RAD1,
POLQ,
TADA2A,
RECQL4,
KIF4A,
IL33,
WHSC1,
CENPB,
BRCA1,
RECQL,
CENPE,
FMR1,
SSRP1,
LRMP,
PRPF4B,
MDC1,
SMC1A,
ZMYND11,
PUM3,
PPP1R7,
PDS5A,
CDCA2,
FAAP20,
WAPL,
RBBP6,
SIRT2,
TOP6BL,
ZBTB38,
BOD1L1,
GSG2,
SETD7,
TOPBP1,
UTP4,
CDCA5,
DDX27,
ZFR,
SETDB2,
LLPH,
RHNO1,
NUSAP1,
WHSC1L1,
KMT5A,
ASH1L,
PDS5B,
INTS7,
DTL,
HMG20B,
ZBTB4,
NSFL1C,
SMC3,
LOXL2,
SUPT16H
|
|
GO:0005697
|
CC
|
telomerase holoenzyme complex
|
Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.
|
DKC1,
HNRNPC,
SNRPB,
SNRPD3,
HNRNPU,
PTGES3,
TEP1,
NOP10,
GNL3L,
GAR1,
SMG5
|
|
GO:0005712
|
CC
|
chiasma
|
A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over.
|
MLH1,
PMS1,
MLH3
|
|
GO:0005719
|
CC
|
nuclear euchromatin
|
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
|
KLF4,
JUN,
H2AFZ,
CREB1,
HIST1H1C,
CTNNB1,
RBMX,
HIST1H1A,
CBX3,
TRIM28,
ALKBH1,
NSMF,
NR1H4,
PPARGC1A,
ASH2L,
RUVBL2
|
|
GO:0005720
|
CC
|
nuclear heterochromatin
|
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
|
H2AFZ,
HIST1H1E,
TCP1,
CBX5,
ATRX,
CBX1,
SATB1,
FOXC1,
CBX3,
TRIM28,
KMT5C,
SIRT2,
EME1,
UHRF2,
UHRF1,
MPHOSPH8
|
|
GO:0005721
|
CC
|
pericentric heterochromatin
|
Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
|
H2AFY,
DNMT1,
CBX5,
ATRX,
CBX1,
CENPC,
KMT5C,
HELLS,
LRWD1,
BAZ1B
|
|
GO:0005726
|
CC
|
perichromatin fibrils
|
Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts.
|
TARDBP,
NUFIP1
|
|
GO:0005730
|
CC
|
nucleolus
|
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
GTPBP10,
MIF4GD,
AGPS,
MYO1C,
IPO5,
PLK4,
BTN3A3,
ZNF593,
NOP56,
NFIB,
BHLHE40,
CHD2,
ENC1,
CASK,
XPO1,
SMAD7,
PLSCR1,
CETN3,
UBD,
FANCG,
CD3EAP,
DHX15,
PLRG1,
ZNF207,
ASNA1,
SMARCA5,
NUAK1,
REV3L,
CDC14B,
DKC1,
EDF1,
DIAPH2,
NBN,
NOL3,
N4BP1,
ZPR1,
H2AFY,
PEX14,
TULP3,
DAB1,
NPM3,
UTP20,
RSL1D1,
FGF18,
SRP72,
IKBKAP,
SNAPIN,
SMC2,
TACC2,
PARN,
NSA2,
TDP2,
POLR1A,
MYC,
ANG,
CSTB,
TP53,
TYMS,
KRT18,
NPM1,
CTSB,
NFIC,
SNRPA,
HMOX1,
PARP1,
POLA1,
MAP2,
TOP1,
TOP2A,
ESRRA,
CDK4,
XRCC5,
EZR,
GCFC2,
UBTF,
DDX5,
RPL7,
ATF3,
WT1,
NCF2,
FLNA,
OSBP,
DNAJB1,
HMGB2,
PTBP1,
KDM5A,
EEF1D,
RPL12,
CCND2,
WEE1,
NF2,
RPL4,
PPP1CC,
POLR2I,
COIL,
CDKN1A,
FEN1,
CAPG,
RPL13A,
RGS2,
SKIV2L2,
PIK3CB,
RPL35,
CBX5,
MKI67,
NOP2,
RPL5,
RPL21,
RPS9,
RPS10,
NRIP1,
RPL34,
CDK8,
ARL4D,
ACADVL,
NUP153,
MXI1,
FXR1,
NOVA1,
SMARCA4,
NEK2,
HNRNPM,
PLK1,
TTC3,
SUB1,
BLM,
TERF1,
SNU13,
EIF6,
GEMIN4,
NLRP5,
SRP54,
YPEL3,
RPS3A,
RPS7,
PPP1CA,
PPP1CB,
RPS14,
RPS13,
RPS11,
LSM6,
RPL7A,
RPL23A,
RPS6,
RPS25,
RPS26,
RPL10A,
RPL11,
RPS27A,
GRB2,
EEF1A1,
PAFAH1B2,
SRPK2,
RAE1,
PRKDC,
ADARB1,
RPL19,
ZBED6,
DAB2,
RBM3,
SLC25A3,
GTF2B,
MDM2,
SPTBN1,
XPC,
EWSR1,
TLE1,
ZBTB16,
EXOSC9,
RAD51,
FMR1,
RPL18,
C1QBP,
PPID,
SSRP1,
NSUN2,
TBL3,
ILF2,
ILF3,
CHAF1A,
SELENBP1,
SRSF9,
SRSF5,
SKP2,
SLC14A1,
ORC1,
TCOF1,
TRA2A,
PWP1,
CUL2,
EXOSC2,
C1D,
CIRBP,
VEZF1,
BOP1,
EIF3A,
RCN2,
ITPR3,
ITPR1,
RRP1B,
MORF4L2,
SEPT2,
SUZ12,
EXOSC7,
RRS1,
ACOX1,
NONO,
RBBP5,
ANKRD1,
PUM3,
ZFHX3,
SEPT7,
SNAPC1,
MRPL23,
IFI16,
KNOP1,
TSR1,
CERKL,
MIDN,
CDCA8,
SMUG1,
NOM1,
CENPW,
RRP12,
ZNF506,
DNTTIP2,
EXOSC6,
RSPH4A,
ATF7IP2,
ARL6IP4,
SPTY2D1,
JMJD6,
INO80C,
ZC3H14,
WDR74,
C6orf89,
KDM7A,
RNF111,
NOL8,
ZNF771,
MCM10,
SETX,
RBBP6,
PCGF5,
ZBTB33,
MTDH,
JAZF1,
SPATA24,
RPS19BP1,
MINA,
DHX40,
KLHL7,
DHX37,
ZCCHC7,
NIN,
ZCCHC9,
OXR1,
AOPEP,
ZNF655,
KRI1,
SPC24,
INO80E,
HJURP,
PAPD5,
NGDN,
NEK11,
WDR36,
DDX54,
HELQ,
STK35,
UTP15,
SETD7,
ZC3H15,
PHLDA1,
TRIM41,
UBLCP1,
TSEN15,
PSPC1,
PPM1E,
ARNTL2,
H1FX,
RTF1,
MRPS31,
ANP32B,
P3H4,
KAT6A,
DDX17,
FGF13,
EMG1,
MED12,
UTP4,
EME1,
ISG20,
EXOSC8,
CHCHD1,
NUDT16,
MBD6,
S100A16,
ZNF274,
VMP1,
CDCA7L,
DDX27,
SENP5,
CDKN2AIPNL,
ABHD14B,
KIF20B,
YPEL2,
ERGIC2,
USP28,
FAM129B,
CDC5L,
MPHOSPH8,
SCAF11,
TXN2,
EBNA1BP2,
ARID3A,
HAUS7,
VRK1,
RBM4B,
MYBBP1A,
LLPH,
UTP23,
FAM64A,
DDX23,
THUMPD3,
GNL3,
HIRIP3,
ACAT2,
RBM4,
HINT2,
NUSAP1,
FANCD2,
NIFK,
MRO,
INO80B,
WDR12,
DDX24,
POLR1E,
KATNBL1,
USP44,
DDX47,
THAP2,
DNTTIP1,
TSPYL2,
SENP3,
OBFC1,
NOL11,
DDX31,
AKTIP,
ELP3,
LIN28A,
MEAF6,
SAP30L,
SP110,
MKNK2,
MYO10,
EXOSC4,
NOX4,
MRPL40,
EXOSC3,
SNX15,
BRWD1,
MDN1,
STAU2,
DDX28,
SPATS2L,
DCAF13,
GNL3L,
SDAD1,
THAP1,
GPATCH2,
PAK1IP1,
LYAR,
ZDHHC7,
ING3,
CDKN2AIP,
GAR1,
AATF,
BCLAF1,
CDK12,
RRN3,
FMN2,
GPRC5B,
IL37,
DTL,
GLTSCR2,
THYN1,
CRIPT,
USP36,
CHD7,
KANSL3,
DNAJB9,
PARP2,
NOL12,
NUFIP1,
HN1,
MRTO4,
PNMA3,
PNMA2,
TAOK2,
PYCARD,
PHTF1,
NOL7,
DIMT1,
TIMELESS,
WDR3,
PA2G4,
NIP7,
PIN4,
KDM2A,
RCL1,
DDX52,
CRYL1,
POLR3K,
FCF1,
SBDS,
REXO2,
ZNF330,
NOC2L,
RPL36,
LAS1L,
UTP18,
SPIN1,
STK24
|
|
GO:0005732
|
CC
|
small nucleolar ribonucleoprotein complex
|
A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type.
|
NOP56,
SNRPF,
LSM6,
SNRNP40,
NAF1,
NOP10,
LSM7
|
|
GO:0005736
|
CC
|
DNA-directed RNA polymerase I complex
|
RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
|
POLR1C,
CD3EAP,
POLR1A,
POLR2E,
POLR2K,
POLR2L,
POLR1E,
ZNRD1,
POLR1D
|
|
GO:0005737
|
CC
|
cytoplasm
|
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
UBA6,
SH3PXD2B,
FRMD3,
PTPDC1,
MEIOC,
KIAA0922,
TMEM189,
CNOT1,
CCDC42B,
ASB14,
GOLGA8A,
C4orf47,
BBIP1,
MIF4GD,
AHRR,
FAM195B,
NACA,
DDX39A,
PDLIM1,
ACOT7,
MYO1C,
SNAP23,
AIP,
TLR4,
APBB1,
PSMD12,
DFFA,
HIP1,
CLIC1,
WWP2,
CDC7,
IPO5,
SAP18,
IGF2BP3,
PIK3C2A,
IFRD1,
EXOC5,
ELL2,
BTN3A3,
NR5A2,
BIN1,
KRIT1,
SDCBP,
NOP56,
DDX3X,
UBE2C,
PDXK,
SOCS2,
SOCS3,
SOCS6,
ARHGAP33,
DYNC1I1,
CCS,
ABLIM1,
DNALI1,
CHD1,
ADAM10,
ENC1,
ITGB1BP1,
MAP2K7,
PDCD5,
TNPO2,
TNFSF11,
MSTN,
BACH1,
IRF6,
TAX1BP3,
RGS12,
CASK,
TFEC,
RAB29,
PPP1R12A,
AZIN1,
HNRNPDL,
XPO1,
PDZD2,
MAST4,
PFAS,
NACAD,
SMAD7,
KPNA5,
ARPC2,
AXIN1,
SMAD9,
UBD,
PFDN6,
ZNF185,
FANCG,
SIVA1,
INPP4B,
HMGB3,
PPM1G,
HDAC3,
BIRC5,
CD3EAP,
TLR3,
P4HA2,
MAGEB4,
CAPN5,
NUPL2,
CFLAR,
SOCS1,
CYP27B1,
PER1,
RGS5,
DHX15,
FLRT2,
ARHGAP6,
IRAK2,
PSMD3,
RBFOX2,
SIAH2,
SPINT2,
DAPK3,
TGFB1I1,
AP5Z1,
CTIF,
MTSS1,
MAP3K7,
EEF1E1,
RIPK2,
PRPF3,
PPIH,
KLF4,
OIP5,
CACNA1G,
RAD51C,
FOXO3,
SMAD6,
AKAP10,
SPRY1,
SNAI2,
PRC1,
ZNF207,
ASNA1,
BUB1,
ACTN4,
SGTA,
ENSA,
C21orf2,
AHCYL1,
CD5L,
ORC5,
DHX16,
SH3BP5,
SOX15,
PARK2,
ADCY3,
KIAA0513,
SPAG9,
KIF5C,
NUAK1,
TRAK2,
LZTS3,
OPA1,
TBC1D4,
NUPR1,
GDF9,
BRINP1,
ACSL4,
SNX3,
RANBP6,
GMDS,
NMT2,
BUB1B,
TLR2,
JAK2,
PRMT3,
SRPX2,
LPXN,
CTNND1,
CDC14B,
HIST1H2BK,
PQBP1,
DKC1,
EIF5B,
GAS7,
EDF1,
BRD4,
PPP1R11,
WDR1,
AOC2,
MFAP3L,
OBSL1,
TSC22D2,
SOCS5,
SIN3B,
GADD45B,
ZPR1,
PDCD6,
VPS4B,
FLNB,
ULK1,
TULP3,
PRPF40A,
TACC1,
MAF,
ERN1,
SRSF10,
GMNN,
BANF1,
SKAP2,
PRKRA,
RPS6KA5,
LYPLA1,
ADAP1,
UTP20,
RP2,
WDHD1,
RAD51D,
RNASEH2A,
CDC123,
PPP1R15A,
CAPN15,
POP7,
PSMD10,
IDH1,
STAM2,
TNFSF13,
ALDH1L1,
GABBR2,
PAK3,
ATP5H,
SASH3,
CLPX,
SEC14L2,
RNF8,
ZFAND5,
SRP72,
DXO,
RECQL4,
URI1,
ALDH1A2,
TPPP,
SLIT2,
PLEKHG5,
FARP2,
LRIG2,
PROSC,
ERLIN2,
NFAT5,
ABLIM3,
KDM4B,
WDR47,
TRIM37,
SEC31A,
HEXIM1,
UBR5,
FSBP,
UBE4B,
IKBKAP,
OAZ2,
SNX4,
ZWINT,
KIF4A,
GADD45G,
VAPB,
CELF2,
SMC2,
TACC2,
LYPLA2,
WISP1,
BMP10,
CD2BP2,
PARN,
PSMG1,
CTDNEP1,
SLC2A10,
TDP2,
ETHE1,
POLR1A,
PCNT,
STAMBP,
NFATC1,
EYA4,
APBB3,
SNAP29,
ZMYM6,
STAU1,
MAP4K4,
CLIC3,
EML2,
DDAH2,
C6orf47,
TTLL1,
CBX7,
BMP15,
MBD3,
NUDT3,
PTTG1,
BCL10,
ZBED1,
TOMM40,
DNAL4,
WHSC1,
CYB5A,
ALDH1A1,
CYB5R3,
PNP,
EGFR,
AK1,
PLAT,
ADA,
CA2,
ASS1,
AGT,
CSTA,
KRAS,
PDGFB,
TGFB1,
POMC,
FSHB,
CRYAB,
LMNA,
APOE,
PMP2,
TTR,
FTL,
FTH1,
MT2A,
BGLAP,
ESR1,
RAF1,
FUCA1,
CSTB,
ANXA1,
APOB,
NR3C1,
PRNP,
S100B,
GAPDH,
ERBB2,
TP53,
MT1E,
MT1F,
HSPB1,
TYMS,
GNAI2,
APP,
INHA,
HMGN2,
IL6,
EDN1,
RPLP1,
RPLP0,
CLEC3B,
ITGB1,
PRKCB,
KRT18,
KRT8,
UROD,
PTMA,
CDK1,
S100A6,
EIF4E,
ENO1,
GPI,
NPM1,
TH,
LDHB,
GPX1,
DCN,
PSAP,
PFN1,
APRT,
EPRS,
HSP90AA1,
LYN,
FH,
ERCC1,
SLC3A2,
HSP90AB1,
SOD3,
MME,
VIM,
CYP3A4,
KRT7,
GNAI3,
ANXA5,
RPSA,
SNRPA,
GSTP1,
LGALS1,
QDPR,
RBP1,
FBP1,
SPARC,
GSTM1,
ANXA4,
CNP,
WNT2,
PDGFRB,
HNRNPA1,
POLA1,
UCHL1,
GSTT2,
TMSB15A,
HSPA1A,
HSPA1B,
GLI3,
CCL3,
TROVE2,
AR,
BCL2,
TXN,
PRKAR1A,
HSPD1,
CLU,
IRF1,
MAP2,
EGR2,
UMPS,
PYGB,
PYGM,
LAMP1,
G6PD,
PC,
ODC1,
PCNA,
NEFH,
HARS,
TPR,
PTHLH,
CKB,
ANXA3,
SKI,
ACTN1,
RNH1,
CCL5,
CFTR,
NCAM1,
EEF2,
MT1G,
TPT1,
LCP1,
PRKAR2A,
ENO3,
HSD17B1,
MIF,
CD99,
HCLS1,
FDPS,
PKM,
CCNB1,
TYR,
IDE,
HNRNPL,
DARS,
ETS1,
JUP,
LIF,
ETS2,
FABP4,
AKR1B1,
PVR,
EZR,
UCHL3,
HPGD,
NME1,
NQO1,
VEGFA,
CD1D,
RPS2,
CHN1,
TCF3,
DSP,
CD44,
NQO2,
PDGFRA,
STMN1,
HSPA6,
PRKCA,
ATF7,
CEBPB,
GAP43,
XBP1,
LGALS3,
ERCC2,
RPL7,
EGR1,
IL1RN,
PGAM1,
RCC1,
SDC1,
ATF4,
CDH2,
TFEB,
WT1,
NFKB1,
NCF2,
CCNA2,
BTF3,
RAB3B,
RAB5A,
NR1D1,
BCL3,
MAK,
CAPN3,
IL11,
CAST,
HNF1A,
MAG,
RASA1,
PDC,
CDK11B,
GSTM3,
FLNA,
TNFAIP3,
KITLG,
NT5E,
MDK,
ZP3,
FGFR2,
BGN,
BMP6,
OSBP,
PCMT1,
PAICS,
IL10,
SCP2,
UBA1,
NME2,
HNRNPA2B1,
CALB2,
NR4A1,
XPA,
PTGS1,
SFPQ,
TUBG1,
JAK1,
SP100,
AHCY,
CFL1,
BDNF,
RRM1,
GADD45A,
EEF1B2,
CDK2,
APC,
BRD2,
FAS,
YY1,
DNAJB1,
MT3,
PSMA3,
PSMA4,
S100P,
CTNNA2,
CHML,
HMGB2,
TARS,
ZFP36,
ACVR2A,
STOM,
ARNT,
CALR,
IL1R2,
PIK3R1,
PSMB9,
GSTM2,
SSFA2,
POLD1,
MAPK1,
DUSP1,
PTPRM,
LAP3,
TNFRSF8,
PTPN4,
TPP2,
IMPA1,
KDM5A,
IL12A,
NOS3,
SERPINB3,
LMOD1,
EEF1D,
GNA11,
PBLD,
PRDX6,
BLVRB,
DDT,
CMPK1,
CDC27,
CCND3,
WEE1,
CDC25B,
ADSS,
TSPO,
CLIP1,
SRI,
SERPINB1,
SSTR1,
CORO1A,
GDI1,
S100A7,
HOXA10,
PRKAR2B,
RRM2,
FGF9,
TIA1,
AKT1,
HNRNPH1,
YWHAB,
SFN,
S100A11,
PRDX2,
CTH,
HIST1H2BB,
MAN1A1,
TTK,
MCM7,
SHMT1,
GRK5,
USP6,
CA8,
CTNNB1,
PHB,
NF2,
RPL22,
ADM,
SPRR2B,
PTGS2,
HRH1,
CBS,
PCK1,
IRS1,
AGL,
MYH9,
AHR,
FLT4,
PSMC2,
CHI3L1,
MAP2K2,
CPOX,
RPL4,
NUDT1,
PGM1,
PPP1CC,
SERPINB5,
SREBF1,
GMPR,
SRP14,
NUP62,
ZEB1,
TALDO1,
SNCA,
BRCA1,
ANP32A,
CAPG,
CCT6A,
PBX1,
RPL13A,
STAT3,
MDH1,
EIF2S3,
LEP,
MNDA,
RGS2,
CSK,
MAP3K8,
EIF1,
HTR2B,
PRKCI,
ACTR1B,
STAT5A,
AKR1C3,
EPS15,
RPL35,
CDKN2B,
CDKN2C,
NSG1,
HTT,
PTGFR,
NR4A2,
PTPN9,
SYK,
RANBP1,
PSMC4,
PPIC,
MKI67,
RANGAP1,
RECQL,
NSF,
CDKN1B,
BRCC3,
RPL5,
RPL21,
RPL28,
RPS9,
MAP1B,
GNPDA1,
YAP1,
IQGAP1,
PLA2G4A,
ALDH1A3,
ID4,
LGALS7,
ZFP36L2,
PREP,
GLRB,
RFX2,
ARCN1,
SERPINB4,
PRRC2A,
NES,
PIK3CG,
MAPKAPK2,
ALDH9A1,
RPL34,
TGM4,
SLC11A2,
NASP,
FASN,
DHPS,
CCT3,
ALDH7A1,
CDC34,
INPP1,
CENPF,
UBE2A,
SARS,
CSNK1E,
ARL4D,
PSMB3,
MCM2,
ACADVL,
RBM25,
HINT1,
FHIT,
NUP153,
RGS3,
RGS4,
TSC2,
GSK3B,
SEPHS1,
MTHFS,
GMPS,
CDKN1C,
MRE11A,
HNMT,
GNAQ,
MEOX1,
MMP14,
GDI2,
SERPINB9,
MXI1,
METAP2,
CDK7,
KNTC1,
RPL14,
CCT8,
ATP1A2,
ANXA11,
PAPOLA,
FXR1,
RAB28,
FABP6,
PLCD1,
DUSP3,
BRCA2,
IRAK1,
STAT5B,
USP11,
VAMP7,
PRKX,
AFF3,
NR0B1,
HDGF,
NEK2,
NEK3,
NEK4,
HNRNPA3,
KPNA2,
KPNA1,
MAP2K6,
ARHGDIB,
STAT2,
GTF2A1,
MSH6,
KIF11,
HRSP12,
STC1,
AKR1C2,
PLK1,
DAPK1,
SUCLG1,
COPA,
LIMK2,
PTTG1IP,
TTC3,
RCAN1,
SMTN,
BLM,
RARS,
ATXN3,
ATXN1,
ATN1,
TERF1,
OAZ1,
YARS,
PRKAA2,
RAD23B,
EPHA4,
GYS2,
EMP2,
ALDH18A1,
EIF5,
NR1H2,
CSE1L,
VCP,
MLLT10,
CASP6,
CDH11,
CDH13,
TPD52,
GFER,
HNRNPH2,
SUMO3,
EIF3B,
DLX5,
ARPP19,
HDAC4,
EIF6,
SIK1,
SOX8,
GEMIN4,
EVC,
SESN2,
SESN3,
EPPK1,
TIRAP,
HIST1H2BD,
PTEN,
PPP4C,
GABARAPL2,
ACTB,
EIF4A1,
RPS20,
SNAP25,
CDC42,
SRP54,
CXCR4,
UBE2M,
ACTR2,
ABCE1,
RPS3A,
PSME3,
STXBP1,
B2M,
PKIA,
UFM1,
DCAF7,
RPS7,
PPP1CA,
CALM2,
NCS1,
PSMC1,
RPS8,
RPS15A,
UBE2H,
RPS14,
RPS11,
SNRPD3,
BTG1,
TMSB4X,
RPL7A,
ACTA2,
RPL23A,
RPS6,
HIST1H2BC,
RAP1A,
RPS25,
RPS26,
RPL30,
RPL10A,
RPL11,
RPS27A,
GRB2,
RAC1,
GNAI1,
YWHAZ,
UBE2B,
SNRPN,
DYNLL1,
SKP1,
RPS21,
EIF5A,
RACK1,
ACTG2,
UBE2I,
TMSB10,
YBX1,
ACTC1,
EEF1A1,
PAFAH1B2,
CXADR,
IGBP1,
ADAM8,
GTF2I,
DLG4,
SRPK2,
CCT2,
RAE1,
IRX3,
GSTO1,
ADAM17,
ELF3,
MAP1A,
CRADD,
ADARB1,
GPLD1,
MT1H,
MT1X,
GPSM2,
SSBP2,
RPL24,
SMAD3,
RPL19,
MUC5AC,
PKD1,
XIAP,
FOXO4,
RBM3,
PITPNA,
HDLBP,
CDK6,
CDK5,
CDK16,
PURA,
HSF1,
IRF9,
MDM2,
PLIN5,
SPTBN1,
SET,
RUNX1,
RELB,
GALK2,
FABP5,
HMGCS1,
SLC7A5,
MC2R,
XPC,
EWSR1,
POU5F1,
BNC1,
OCRL,
ROR1,
TAGLN,
MEF2A,
DHODH,
CENPE,
NRG1,
ID2,
SP3,
ID3,
MAP2K1,
TEK,
FKBP4,
DST,
GSTM4,
HHEX,
CREM,
TGFBR3,
CENPC,
RELA,
KRT17,
TLE1,
GLO1,
YWHAH,
ICA1,
PTK2,
EEF1A2,
PRKCD,
PTPN11,
EXOSC9,
AOX1,
MEF2C,
SULT2A1,
RING1,
RAD51,
FMR1,
PRDX1,
SOX4,
RPL18,
C1QBP,
TJP1,
ZFP36L1,
BAX,
MCL1,
TNK2,
SRSF1,
FOXM1,
PPP3CA,
CRYZ,
PPID,
SSRP1,
CAMSAP2,
NSUN2,
NCBP1,
EP300,
AHNAK,
DNAH14,
FAAP100,
BST2,
SREBF2,
ARHGEF5,
FOXO1,
TWF1,
AKAP13,
TROAP,
CDC20,
GRSF1,
MERTK,
DPYD,
HYAL2,
ILF2,
ILF3,
FOXC1,
DLG1,
TAF10,
MYO1E,
PTP4A2,
BNIP3,
HSPB3,
MLLT11,
ARHGAP5,
AKAP6,
STK4,
COASY,
TRAF1,
PLA2G7,
CHAF1B,
MTAP,
CALCOCO2,
EIF2B5,
BAMBI,
TARDBP,
FADD,
MAP2K5,
MAPK7,
PAK2,
CBLB,
DUSP8,
DNAJC3,
SRSF5,
G3BP1,
CLN3,
NMI,
SKP2,
GRB10,
MTA1,
ITGB3BP,
PPIL2,
PDCL,
MAPK8IP2,
UBE2V1,
DYNC1I2,
ORC1,
ILK,
IKZF1,
SNTA1,
SNTB2,
PPIG,
TCOF1,
GOLGA4,
MYO9B,
NFATC2,
SMAD4,
BIRC3,
MTM1,
SQSTM1,
TUBB3,
PPP1R1A,
EIF4EBP1,
EIF4EBP2,
RIPK1,
HDAC1,
CAMK2D,
DCTN2,
PKD2,
NAE1,
DGKZ,
IQGAP2,
SNX1,
MTMR1,
MTMR2,
CUL4B,
TP53BP2,
FHL1,
ACVR2B,
TUBA3C,
RUNX3,
NACA,
BLMH,
EXOSC2,
BMPR2,
SNTB1,
TUBB2A,
KLF9,
C1D,
CACNA1C,
RUNX2,
CDK13,
CIRBP,
CAMK1,
COTL1,
COX17,
TOB2,
DAG1,
BOP1,
EIF3A,
POLA2,
ZMYM3,
DCTN1,
NPAT,
EIF2B1,
MAP7,
CTTN,
TRIM25,
FLNC,
GAS6,
CAPRIN1,
GRB14,
HES1,
SLBP,
NFE2L1,
NEDD9,
ITPR3,
ZNF268,
RASA3,
PLS1,
ESPL1,
KANK1,
SMC1A,
GINS1,
LPIN1,
RFTN1,
CASP8,
NAA30,
KIF22,
MEF2D,
CHD4,
STARD3,
PTGR1,
NFATC4,
ZNF638,
KPNB1,
CUL7,
NAA25,
KIAA0101,
EMC2,
FAM175B,
SEPT2,
SART3,
NCAPD2,
HERC3,
JOSD1,
KARS,
EEA1,
PAFAH1B3,
PLCL1,
PRKD1,
PCM1,
PPP2R5A,
PPP2R5B,
PTGES3,
STK38,
PPP2R4,
QPRT,
RASA2,
RNPS1,
ANKRD1,
RPS6KA2,
PCBP1,
UBE3C,
MTFR1,
DLGAP5,
CNN3,
RPS6KA1,
PPP1R7,
NR0B2,
STIL,
RGN,
SPA17,
MAPRE2,
NCOA2,
DIXDC1,
TRADD,
TRIP10,
TRIP6,
MAPRE1,
TSC22D1,
ELAVL1,
KISS1,
MYLK,
TAB1,
NPY5R,
NCOA1,
SMAD2,
SMAD1,
UBE2V2,
STK11,
CCDC85B,
ADIRF,
EZH2,
ZFHX3,
ZIC1,
ZYX,
HSPB2,
SEPT7,
ADRM1,
CCDC6,
UAP1,
PDCD2,
PKN1,
PKN2,
MAPK14,
CDC37,
SGCB,
CCNG2,
NREP,
DBN1,
FSCN1,
HIF1A,
IFI16,
CDKN3,
ZSCAN26,
DECR1,
KYNU,
UBE2S,
HIST2H2BE,
PTPN21,
DUSP6,
HADH,
AOC3,
TPD52L1,
CPEB4,
CSPP1,
FAM110C,
MICA,
AAK1,
KIZ,
ERCC6L,
RALGAPA2,
QRICH1,
LRRFIP1,
FAM161A,
NBPF1,
MAP7D1,
CHD9,
WDR72,
TTLL9,
RABL6,
GLYR1,
ZBED5,
COX19,
LARP7,
FILIP1L,
ARID4B,
FLYWCH1,
C4orf46,
RFTN2,
FAM98B,
ARHGAP29,
SBK1,
PDCD4,
NCBP3,
IFI44L,
PHLDA2,
PLEKHO1,
C1QTNF9B-AS1,
DCAF6,
SGOL1,
HERC4,
BCORL1,
TECRL,
MDH1B,
METTL10,
RALGPS1,
HABP4,
DGKK,
WIPI1,
SAMD4B,
TBCEL,
CEP170,
FNBP1L,
HIVEP3,
ARMC4,
UBR4,
STXBP5,
KIAA1217,
CAMSAP1,
KANK4,
CPSF3L,
DCAF8,
RSPH4A,
THEMIS2,
STPG1,
FAM72A,
CROCC,
MEX3C,
HECTD2,
ATF7IP2,
RIF1,
STRIP1,
CDC42BPA,
CFAP126,
PDE4DIP,
IRAK1BP1,
FAM208B,
ZCCHC6,
MBNL2,
LRRC16A,
KANK2,
KAZN,
KCTD11,
CDCA2,
IQSEC1,
SFRP4,
ZFAND6,
OTUD7B,
RALGAPA1,
THOC7,
NADSYN1,
TWF2,
DESI1,
JADE1,
PPP4R3A,
SPOPL,
NAPEPLD,
FAM72D,
RGS7BP,
TENM4,
PTRF,
MAST2,
PNCK,
C16orf46,
KLC3,
LRRC8B,
CNKSR3,
RFWD3,
PPIP5K1,
PSRC1,
SHQ1,
KLHDC10,
FBXO38,
BRAT1,
ZC3H14,
LARP1,
AGTRAP,
SARM1,
NHS,
KLHL24,
ANKRD12,
ANKRD11,
AFTPH,
CRTC3,
PARM1,
C6orf89,
DRAM2,
ATF7IP,
MPRIP,
RAB11FIP1,
NSMF,
DSTYK,
RNF19B,
BNC2,
CCDC81,
RNF111,
CCDC141,
DNAH12,
FAM83H,
RBPMS2,
FAM65A,
GK5,
RNF165,
UBR3,
FAM101A,
CEP128,
FGD6,
PHLPP2,
SYDE1,
NEK10,
VPS13C,
RAPH1,
USP45,
NOL8,
SSH2,
RUFY3,
SV2A,
BZW1,
ASRGL1,
DHX30,
MCM10,
COPS6,
MAEA,
EPM2AIP1,
DHX32,
SH3BP5L,
ARC,
CXXC5,
PID1,
NRK,
SETX,
NOTCH2NL,
ZFYVE16,
PIWIL4,
TMC6,
NUFIP2,
RNF144B,
COMMD6,
HAUS6,
WAPL,
PODN,
IRF2BP2,
CPEB2,
BCDIN3D,
KCTD20,
SPRED1,
SRGAP1,
NECAB2,
FGD2,
PNPLA5,
HUWE1,
PXK,
CENPV,
S100A7A,
NEK8,
PHLDB2,
ZBTB33,
NBPF11,
PEG10,
PRUNE,
PABPN1,
MTDH,
MAGI2,
RTN4RL1,
USP48,
CASZ1,
VASH2,
LRRTM4,
CAND1,
HOOK3,
JAZF1,
SPATA24,
OSTM1,
RASSF3,
NLRC5,
CHD1L,
GPBP1,
TRIM69,
RPS19BP1,
RALGPS2,
CARM1,
FAM72B,
COMMD2,
METTL23,
C19orf68,
GAS2L3,
DGKH,
CEP57,
RNF130,
SPATS2,
DNAAF5,
KIF18B,
PDSS2,
THNSL2,
TDRP,
C2CD5,
MIB1,
CAMK1D,
ERC1,
MINA,
RBM45,
ZDHHC17,
CRLF3,
SIAH1,
CREBRF,
AEBP1,
LRRC49,
HID1,
PLEKHH2,
DNAH10,
MAP4K3,
CCDC50,
CCDC103,
TEX14,
FAM114A1,
MGA,
UBR1,
CHERP,
WWC1,
DHX40,
SKA3,
SIRT2,
BAP18,
KLHL7,
DDIAS,
CMIP,
DHX37,
YAF2,
AMOTL1,
EFCAB13,
CKAP2L,
TRIM22,
THNSL1,
C6orf165,
CMTR2,
CFAP46,
ANKRD13A,
ZBED8,
PHACTR4,
KMT2E,
SCYL3,
XRN1,
ASPM,
CMTM8,
RDH10,
SPG20,
CNTROB,
EID3,
ADSSL1,
CCAR2,
CRIPAK,
CFAP52,
AGGF1,
MT1M,
ARHGAP18,
ASCC3,
FAM19A2,
MPP5,
ZCCHC7,
MINK1,
AFAP1L2,
TAB3,
NKAP,
FAM101B,
NBPF15,
COMMD1,
DRAM1,
RNF182,
ARFGAP2,
AOPEP,
ZNF655,
KLHDC1,
C7orf31,
KIAA1958,
ENAH,
ABTB2,
CNEP1R1,
JMY,
MFSD2A,
PCSK9,
HSD17B11,
SERBP1,
HJURP,
NFATC2IP,
BBOF1,
LRRC16B,
LSM14A,
PAPD5,
RCBTB1,
RGS22,
CPEB3,
ABCF1,
PLPP5,
GSTCD,
DUSP18,
NGDN,
MCPH1,
SHCBP1,
APPL2,
NAV1,
VPS37A,
ZNF397,
USP32,
ARID1B,
FLCN,
REPS2,
NUDT10,
DBF4B,
SEMA6D,
CASC5,
LILRB1,
CEP70,
CTCFL,
KIF18A,
RP9,
PPP1R14C,
RHEBL1,
MPLKIP,
PUM2,
SETD6,
TBC1D15,
SPATA18,
FAM110B,
IFI44,
NT5C,
KIAA1524,
PNPT1,
URGCP,
BICD2,
NEK9,
DLG5,
STK35,
LRRC8C,
NEK7,
RB1CC1,
MICAL1,
DNAH5,
SSH3,
UTP15,
GEMIN5,
IPO4,
PNISR,
FNIP1,
UBASH3B,
SHROOM3,
GSG2,
ABHD5,
ZC3H15,
PPIL4,
PPP1R13L,
HDAC7,
CEMIP,
PDCD6IP,
PRUNE2,
BLNK,
TRIM41,
CHTF18,
N6AMT2,
NUDCD2,
TNFAIP8L1,
ZFPM2,
CKAP2,
ATXN2L,
ARAP3,
IPCEF1,
STAB2,
RASSF5,
PALLD,
METTL21A,
GEMIN6,
PSPC1,
GPR98,
SYNE2,
DNAJC9,
BBX,
NANOS1,
ARNTL2,
RIN2,
RFFL,
AQP3,
SEC14L1,
TRIB2,
SNX19,
TOPBP1,
ELMO1,
BAP1,
NDRG1,
HSPH1,
LPGAT1,
GCN1,
NUP205,
APPBP2,
ANKS1A,
SGCD,
DYRK2,
NSMAF,
ANP32B,
TFG,
TNR,
HDAC2,
PROX1,
CREBBP,
SYMPK,
TAF15,
HAS2,
TANK,
APBB2,
HPS1,
FGF13,
ARHGEF2,
EMG1,
GLMN,
ATP6V0A1,
LPP,
RBPMS,
HIST1H2BH,
PTP4A1,
PRKCDBP,
RFK,
FBXO32,
UBE2E3,
FBXW5,
TEKT1,
FAM162A,
TP53INP1,
EXOC4,
KIAA1191,
PNPLA2,
TTC17,
NABP1,
ACD,
MIB2,
EME1,
ISG20,
UBE2W,
DACT3,
EXOSC8,
SLC22A18,
ARL8A,
TADA1,
CHCHD1,
MOAP1,
FAM136A,
ARMC5,
SYTL4,
PPP1R14B,
CTHRC1,
HAUS1,
OPTN,
TUBGCP3,
GPRASP2,
TMCO6,
NUDT16,
ANAPC16,
MSI2,
SNRNP40,
DNAH11,
ELP4,
MALSU1,
DAZAP1,
WDR34,
MVB12A,
CYFIP2,
SAT2,
NRBF2,
CDCA5,
CPNE2,
DTD2,
S100A16,
IFT43,
OTUB1,
DPH3,
CFAP36,
NUDT11,
RMND5B,
ZNF274,
CDCA7L,
C5orf30,
TCTN2,
MASTL,
MYO19,
TONSL,
PRR11,
DOCK6,
NAF1,
FBXL20,
BOD1,
ABHD14B,
PAWR,
RSRC1,
ITCH,
VCPIP1,
CHAMP1,
FEM1C,
ZFYVE19,
RITA1,
SCYL1,
FAM84B,
ZFR,
SGCZ,
C9orf72,
RMDN2,
FGD4,
DRC1,
PCMTD1,
GLT1D1,
CMTM3,
NOL4L,
VSTM2L,
ZNF578,
ZNF641,
SPATA13,
FRMD6,
C8orf37,
ASB16,
SLC46A1,
ANKRD27,
CLIC6,
IPO9,
NECAB3,
INPP4A,
ERMAP,
KLHL5,
NEDD4L,
QKI,
SYNGAP1,
FAM193B,
NEK1,
PLIN4,
BTBD9,
SMG1,
KIF20B,
DLC1,
MTMR9,
ALPK1,
HHIP,
MAGI1,
SPAG5,
PANX2,
PASK,
CITED4,
MED15,
ERGIC2,
NUDCD1,
USP28,
TRIB1,
RANBP9,
SRPK1,
STRBP,
ATOH8,
CEP89,
OSBPL9,
FAM129B,
TCF12,
MYCBP,
CDC5L,
PFDN5,
GPER1,
MPHOSPH8,
MPHOSPH9,
PKP4,
TSC22D3,
S100A13,
TTC1,
DNAJC7,
C12orf57,
PHB2,
COPS8,
RAD9A,
CHP1,
FEZ1,
PITX2,
LYST,
DOK1,
MTR,
HSD17B10,
SMAD5,
BARD1,
HNRNPAB,
LITAF,
NAP1L4,
CDC6,
MDFI,
CIB1,
CCT7,
ARID3A,
HAUS7,
PRMT1,
DUSP9,
CITED1,
TEP1,
VRK1,
GDF15,
NCAPG,
HOPX,
PAIP2,
MAPKAP1,
NABP2,
MYBBP1A,
AIF1L,
SLF1,
DBNDD2,
CORO1B,
CPPED1,
SDF4,
PDCD2L,
AIFM2,
LARP6,
GINS4,
PELO,
FAM213A,
LXN,
FAM64A,
MARVELD1,
FEM1A,
CCM2,
INPP5K,
DIDO1,
IER2,
LRRC1,
TBCD,
NDC1,
MKNK1,
TUBB6,
PDCD10,
MENT,
HTATIP2,
BDH2,
FAM195A,
THUMPD3,
DUSP26,
ADI1,
RNF126,
SNRNP25,
KATNB1,
TUBB2B,
MLST8,
TRIM62,
PHF20,
DUSP23,
TIPIN,
KATNAL1,
ACAT2,
RBM4,
CDCA7,
PAPOLG,
CARD10,
RBM24,
SORBS1,
OSBPL10,
NAA15,
PINK1,
CLEC7A,
NUSAP1,
TEX15,
OSBPL1A,
FANCD2,
BEX2,
PACSIN1,
SCAPER,
HDAC8,
POLDIP3,
DUSP16,
FUT8,
SPRR2G,
NIFK,
PARD6B,
TRIM34,
YTHDF1,
WNK3,
BACH2,
PANK2,
UACA,
WDR11,
CRNKL1,
PRKD2,
FAM129A,
TRIM8,
FOXP3,
UBXN6,
SPRY4,
TRIM9,
TRIM6,
TRIM4,
TRIM2,
INO80B,
LRRCC1,
UNK,
ZCCHC2,
XPO4,
CEP44,
ZNF436,
KLHL4,
STRADB,
ACTR6,
SENP6,
NIF3L1,
NAA50,
UBA5,
PAIP1,
NBPF3,
IQCG,
COMMD4,
TOLLIP,
RNF38,
RACGAP1,
CCDC113,
SIK2,
WWP1,
CCDC8,
BCL11A,
SDCBP2,
NUCKS1,
UPF3A,
SPTBN4,
SH3BGRL3,
TRIOBP,
TSPYL2,
BLZF1,
PDCL3,
TNKS2,
TAOK3,
RAB3GAP2,
DHX36,
HIPK2,
EPB41L4B,
PABPC3,
KCTD10,
TXNIP,
DSN1,
CHMP4B,
FBXL15,
WNK1,
TUBB1,
FAM83D,
SENP3,
PLEKHA4,
RGCC,
GSTO2,
DUSP21,
FAM96A,
DHX35,
BICC1,
ARMC7,
AZI2,
EGLN3,
LRRC19,
ASB8,
SMYD3,
DOCK5,
WDR26,
SUDS3,
AUNIP,
METTL8,
UBE2Z,
RMND5A,
CSRP2BP,
METTL7A,
ZNF395,
AKTIP,
ECT2,
REEP1,
HN1L,
PANK3,
CHODL,
COPS7B,
ELP3,
LIN28A,
MEAF6,
PLEKHA5,
SMURF2,
UPF2,
PLEKHA2,
CACYBP,
RRAGC,
RC3H2,
IFT122,
BEX1,
MKNK2,
AS3MT,
TNS1,
VEZT,
ETNK1,
APOBEC3G,
EML4,
NEK6,
EPG5,
ARHGEF10L,
CWC22,
SYTL2,
RAVER2,
AGO4,
CSNK1G1,
EPB41L4A,
CD248,
SRA1,
GOPC,
SEPSECS,
RANGRF,
MYO10,
CD209,
SLC40A1,
ARFGAP3,
SSU72,
PARD6A,
EXOSC4,
UBE2T,
SPAG4,
ADAP2,
ACP6,
BRD7,
PLCB1,
CASS4,
HEYL,
TCF7L2,
IFT46,
HINT3,
HPS4,
RRAGD,
PFDN4,
KMT5A,
EXOSC3,
KIF13B,
GPHN,
PDLIM7,
ACSS2,
ASH1L,
EIF2B3,
MBNL1,
CYP26B1,
SLC2A4RG,
PDGFC,
EIF4ENIF1,
TULP4,
STRN4,
IL17RB,
LATS2,
CDC42SE2,
UBQLN4,
CDC42SE1,
SNX15,
DUSP22,
RASSF1,
KCNIP2,
RPRM,
RAD18,
HOMER3,
BRWD1,
PNPLA3,
NRBP2,
SMC4,
MDN1,
MBNL3,
DDX28,
LIN7C,
SPATS2L,
UFSP2,
TDP1,
DCAF13,
RNF19A,
EXOC1,
NDFIP2,
FANCI,
ARL8B,
GNL3L,
DNAAF2,
TBCCD1,
ARMC1,
RLIM,
HAUS2,
KBTBD4,
RBM22,
RBFOX1,
PARPBP,
HCFC1R1,
GEMIN8,
TRNAU1AP,
DDIT4,
HYPK,
MKS1,
ING3,
AATF,
SPHK1,
ABI2,
DNAH9,
DACT1,
BCLAF1,
ZAK,
MIS18A,
NKIRAS1,
PLEK2,
PLK2,
STMN3,
FAM120A,
IL37,
GRHL1,
DTL,
ITSN2,
EHD3,
FLRT3,
FLRT1,
LMCD1,
DSPP,
THYN1,
CRIPT,
HACD3,
NDUFA13,
MARK1,
SH3BP4,
SPATA7,
CAMSAP3,
SLAIN2,
FNIP2,
PAK7,
CTTNBP2NL,
DNAH1,
MYEF2,
KLHL42,
WDR35,
HECW2,
STARD9,
FRMD4A,
IMPACT,
ATXN10,
DNMT3B,
SPRR3,
PI4KB,
HECA,
UXT,
ARPP21,
HDAC6,
SPAST,
VPS29,
EIF3K,
GRHPR,
DNAJB9,
GABBR1,
RNF14,
ZMYM2,
TJP2,
DNAJB4,
VTI1B,
ADD3,
PLEKHB1,
LRWD1,
MIOX,
SLC23A2,
ZRANB1,
TES,
KDM5B,
DMBT1,
PARP2,
LIMD1,
MLX,
LIMA1,
ASIC3,
TBK1,
DCDC2,
SLC7A8,
DDX20,
ADAMTS1,
SHPK,
USP25,
BAIAP2L1,
EVL,
EIF2B4,
DACH1,
DNAI1,
TEKT2,
SERPINB13,
PLXNA1,
ZMYM5,
MOSPD1,
ERRFI1,
TUBD1,
FBXL7,
NOCT,
FEM1B,
FBXO10,
FBXO9,
FBXL2,
TNIK,
PITPNC1,
CDC42EP3,
NXT1,
FBXO5,
HDAC9,
AGO2,
ELF5,
NUP50,
BLOC1S6,
TAOK2,
RAB23,
INTU,
RIMKLB,
ZMIZ1,
NDRG4,
PPM1H,
CORO1C,
TP53TG3,
PYCARD,
MYO6,
NFU1,
PRPF19,
PHTF1,
SUFU,
BOK,
SYNRG,
NDRG2,
G3BP2,
RPH3AL,
STUB1,
CDC14A,
SNX6,
GTF2A1L,
DIMT1,
TTF2,
NSFL1C,
MACF1,
PPP6R1,
AGAP1,
TRIM35,
PLCL2,
SMG5,
MAPK8IP3,
TRAK1,
AGTPBP1,
DICER1,
MAPRE3,
PA2G4,
EXO1,
CDK11A,
SMC3,
MAPK8IP1,
HDAC5,
TRPC6,
NIP7,
GNE,
RUVBL2,
AKT3,
POMP,
LZTS1,
RNF6,
POLH,
RUVBL1,
TNFSF13B,
INVS,
FARSA,
DRG1,
PKIG,
STK38L,
EPB41L3,
SIK3,
FRMD4B,
FAN1,
PTPN22,
CRYL1,
GIT1,
SH3GLB1,
ZDHHC9,
RRP7A,
SBDS,
TPRKB,
FAM96B,
RTCB,
TSC22D4,
NOC2L,
RPL36,
KNSTRN,
ZNF175,
MTF2,
TLN1,
NFE2L3,
DAAM1,
WDR7,
USP15,
FARP1,
FAM65B,
GPSM3,
MYO5A,
DTNA,
MAP4K5,
WIPI2,
LAS1L,
ARIH1,
CSDC2,
ASB3,
YTHDF2,
HEY1,
PCYT1B,
TNPO3,
SRPRB,
GMPPB,
CDC42BPB,
RBM8A,
ZNF706,
SNX9,
HEBP2,
HCFC2,
FHOD1,
IRAK3,
PSAT1,
CPQ,
TACC3,
EID1,
MAD1L1,
STK24,
BZW2,
COMMD10,
SNCAIP,
CABIN1,
IGF2BP2,
CSNK1G3,
SLC30A1,
SESN1,
STON1,
NCOA3,
MAP3K4,
DUSP10,
IVNS1ABP,
CAMTA1,
LOC440434
|
|
GO:0005739
|
CC
|
mitochondrion
|
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
VWA8,
GTPBP10,
NUDT19,
AGPS,
ACOT7,
HAX1,
EYA2,
NDUFS8,
CLIC1,
NDUFA4,
NME4,
ACACB,
ACOT8,
TPP1,
TIMM23,
UQCRQ,
RAB29,
SLC27A2,
GNPAT,
NDUFA1,
ACOX3,
SPTLC2,
FANCG,
OGT,
CD3EAP,
CYP27B1,
NDUFS4,
ADAM12,
AKR7A2,
RAD51C,
BCL2L11,
FOXO3,
AKAP10,
GSTZ1,
TRIAP1,
GATC,
SLC25A17,
C21orf2,
IDH3B,
BNIP3L,
SH3BP5,
PARK2,
TRAK2,
OPA1,
KIF1B,
FADS1,
PPL,
MRPS14,
DIAPH2,
NOL3,
PTCD1,
ATG13,
LRP5,
NDUFS2,
MPDU1,
NME6,
ERN1,
ECI2,
LYPLA1,
TRMU,
SLC25A12,
PPP1R15A,
IDH1,
GATB,
ALDH1L1,
TUSC2,
ATP5H,
ATP5L,
CLPX,
DDAH1,
URI1,
PROSC,
GLS,
NDUFB6,
MFN2,
NDUFB4,
NDUFA7,
ZNF205,
LETM1,
SLC25A14,
FARS2,
ETHE1,
AIFM1,
DDAH2,
TOMM40,
CYB5R3,
GOT2,
KRAS,
GNRH1,
CRYAB,
SOD2,
TP53,
CYP1A1,
TYMS,
CYBB,
CYP17A1,
CYP11A1,
SLC25A5,
MPO,
CYP2E1,
FYN,
CDK1,
TH,
LDHB,
GPX1,
PSAP,
CTSB,
UQCRH,
FH,
ANXA6,
HSP90AB1,
MMP2,
PDHA1,
CYC1,
GSTP1,
QDPR,
DLD,
COX6C,
PARP1,
ALDOC,
PET100,
HSPA1A,
HSPA1B,
FDX1,
BCL2,
DLAT,
TXN,
COX5B,
MGST1,
CYP2D6,
HSPD1,
CLU,
HSPA5,
PDHB,
DBT,
PC,
MTHFD1,
NEFH,
HARS,
SLC25A4,
CKB,
CKMT1A,
BCKDHA,
P4HA1,
MTHFD2,
HCLS1,
PKM,
IDE,
COX6B1,
CYP11B1,
HIVEP1,
ARSB,
COX7C,
PRKCA,
GJA1,
CKMT2,
NDUFB7,
PRKACA,
GM2A,
RPL35A,
LIG1,
ATP5J,
CYP11B2,
HK1,
NDUFV2,
ELK1,
NFKB1,
MAOA,
SDHB,
BCKDHB,
COMT,
TGM2,
SCP2,
UBA1,
UQCRC2,
ME2,
GCSH,
DTYMK,
COX7B,
MPST,
UCP1,
PLN,
STOM,
AK4,
MAOB,
MAPK3,
G0S2,
NDUFS1,
MAPK1,
LAP3,
CASP1,
ATP5D,
ECHS1,
PPP2R1A,
TSPO,
ADSL,
SRI,
ALDH1B1,
SDHA,
DNAJA1,
AKT1,
UQCRC1,
YWHAB,
SFN,
GK,
ACSL1,
DUT,
SHMT1,
PHB,
BSG,
GLRX,
HMGCL,
MAP2K2,
ATP5C1,
CPOX,
NUDT1,
PPP1CC,
GPX4,
SNCA,
MPV17,
FEN1,
IFI27,
MDH1,
MDH2,
RGS2,
ELK3,
ECI1,
LRPPRC,
CRAT,
TSFM,
VDAC2,
ACADSB,
MAPK8,
MAPK9,
UQCRFS1,
ATP5O,
IDH2,
RPL34,
FASN,
ALDH7A1,
GLUD2,
HARS2,
CASP4,
STAR,
PSMB3,
ACADVL,
PSEN1,
FHIT,
RANBP2,
GSK3B,
CPT1A,
CDK7,
DAP3,
BCAP31,
HSD17B4,
RAP1GDS1,
HRSP12,
MRPL12,
SUCLG1,
HCCS,
POLG,
RARS,
BCAT1,
ALDH18A1,
HADHB,
CASP9,
GFER,
OXCT1,
UCP3,
BID,
NDUFV3,
CMC4,
MTCP1,
ATP5I,
SYNJ2BP,
SESN2,
YBEY,
NLRP5,
PTEN,
ROMO1,
ABCE1,
HSPE1,
STXBP1,
RPS15A,
YWHAE,
RPS14,
RAB11A,
YWHAZ,
DYNLL1,
GNG5,
RACK1,
NTHL1,
ABAT,
MRPS25,
MRPS10,
MRPS5,
MRPS36,
MRPS34,
CYCS,
TFAM,
SLC25A3,
PLIN5,
E2F1,
DHODH,
OGDH,
ALDH6A1,
MAP2K1,
FKBP4,
SSBP1,
YWHAH,
PTPN11,
RAD51,
PRDX1,
SOX4,
C1QBP,
BAX,
MCL1,
PPP3CA,
NCBP1,
PMPCA,
FOXO1,
GRSF1,
ILF3,
BNIP3,
ECH1,
PRDX4,
CLN3,
TCIRG1,
RIPK1,
TP53BP2,
RAB32,
ALKBH1,
PMAIP1,
AUH,
COX17,
TFDP1,
ICT1,
NBR1,
KCNJ11,
CASP8,
STARD3,
EMC2,
LARS2,
KARS,
POLD3,
ACOX1,
PDK1,
ERBB4,
TOMM20,
MTFR1,
STK11,
RAB11B,
CRY1,
MAPK14,
MRPL23,
DPYSL2,
FXN,
PDK4,
CYP1B1,
DECR1,
KYNU,
CLPP,
ME3,
PCK2,
HADH,
DGUOK,
TXNRD1,
SPHKAP,
PGS1,
ALDH1L2,
TIMM50,
NADK2,
CCDC58,
HS1BP3,
CMPK2,
EARS2,
PITRM1,
COX20,
SLC25A30,
THEM4,
ERCC6L2,
ATPAF1,
FAM72A,
MARC1,
KANK2,
TTC19,
XAF1,
MRM1,
HIBCH,
PTRF,
RPUSD3,
MRPL14,
MTFR2,
TMEM65,
SARM1,
MTHFD1L,
OLFM4,
APOOL,
HSDL2,
SLC25A26,
DHX30,
PARS2,
ENOSF1,
DHX32,
MAVS,
DHX29,
HDDC2,
MAATS1,
CMC1,
USP48,
NT5DC3,
NDUFA11,
ECHDC2,
PPARGC1B,
TMTC1,
ADHFE1,
MSRB3,
MRPL41,
SUPV3L1,
THNSL1,
MICU2,
CLYBL,
NDUFAF2,
ARMC10,
PPM1K,
TCAIM,
PRSS35,
GTPBP8,
GUF1,
PNKD,
TOMM5,
ZADH2,
OXR1,
ATAD1,
UXS1,
ZMIZ2,
ABHD11,
PPTC7,
GADD45GIP1,
NUBPL,
TBC1D15,
FAM110B,
MRPL30,
NT5C,
PNPT1,
MGARP,
RHBDD1,
COX7B2,
PTPMT1,
NUDT8,
DCAKD,
SLC44A1,
PALLD,
SYNE2,
BRI3BP,
PPM1E,
CHCHD10,
CPT1B,
GBF1,
MRPS31,
AKAP1,
ESR2,
RAB8B,
BAD,
RFK,
GTPBP3,
TBRG4,
FAM162A,
CHCHD1,
MOAP1,
MIEF2,
RPUSD4,
SLC25A36,
AP2M1,
DNAJC19,
RMDN1,
ECHDC3,
MTFMT,
STARD4,
LGALS12,
MALSU1,
PTCD3,
PERP,
C7orf55,
COX14,
APOPT1,
DCAF5,
PACRG,
DGAT2,
TRNT1,
TEFM,
GFM1,
MCCC1,
SECISBP2,
NMNAT3,
YME1L1,
MYCBP,
ACOX2,
MTERF1,
TIMM17A,
PHB2,
SDHC,
FEZ1,
HSD17B10,
TXN2,
MIPEP,
ACO2,
CCT7,
NIPSNAP1,
ELAC2,
MACROD1,
MGME1,
AIFM2,
UQCC2,
FAM213A,
AGMAT,
TACO1,
DHRS4,
APOO,
ABHD6,
DUSP26,
MECR,
NUDT9,
ACAT2,
FUNDC2,
SFXN3,
HINT2,
BBC3,
PINK1,
MRPL1,
MRPS26,
PANK2,
MRPL37,
UACA,
MAP1LC3B,
SLIRP,
CCDC90B,
NIF3L1,
QRSL1,
GABARAPL1,
RAB1B,
MTIF3,
C12orf65,
ACBD3,
PIF1,
ACSS3,
METTL17,
MTHFD2L,
SFXN1,
GRPEL1,
AS3MT,
PLGRKT,
CAPN10,
MCCC2,
TRIM39,
MRS2,
MRPL47,
ABCB6,
NGB,
ACP6,
NOX4,
ACOT13,
TIMMDC1,
MRPL40,
XPNPEP3,
PFDN4,
STARD7,
CTPS2,
GLRX2,
TOMM22,
DEPP,
LYRM2,
ABHD10,
DDX28,
NDFIP2,
ATAD3A,
GNL3L,
ARMC1,
MTPAP,
ATP5SL,
ARGLU1,
C14orf119,
AURKAIP1,
DDIT4,
NDUFB11,
OCIAD1,
SYBU,
HAO2,
CISD1,
MRPL35,
COQ3,
MAT2B,
DNAJC27,
MRPL15,
NDUFAF4,
HACD3,
NDUFA13,
TOMM7,
PAK7,
SUCLA2,
AASS,
MUTYH,
AK3,
ANXA10,
CRLS1,
SLC25A13,
CROT,
SARDH,
BAG5,
MTUS1,
NDRG4,
MAFF,
PYCARD,
NFU1,
BOK,
NOL7,
TRAK1,
AGTPBP1,
PRELID1,
BCS1L,
VDAC3,
HIF3A,
MRPS28,
COA3,
POLDIP2,
ACOT9,
MRPS2,
COQ4,
REXO2,
BOLA1,
FAM65B,
SAMM50,
GMPPB,
HEBP2,
MRPS18B,
MRPL42,
CHCHD2,
COX11
|
|
GO:0005740
|
CC
|
mitochondrial envelope
|
The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
|
MAOB,
HADHB,
ABCB6,
ADAP2,
ABCF2
|
|
GO:0005741
|
CC
|
mitochondrial outer membrane
|
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
|
HAX1,
DDX3X,
ACACB,
KMO,
CYP27B1,
CYB5B,
BCL2L11,
BNIP3L,
OPA1,
ACSL4,
PPP1R15A,
MFN2,
TOMM40,
CYB5A,
CYB5R3,
ASS1,
RAF1,
PGR,
CNP,
BCL2,
MGST1,
NME1,
GJA1,
HK1,
MAOA,
MT3,
MAOB,
TSPO,
GK,
ACSL1,
PPP1CC,
IFI27,
VDAC2,
ATP5G3,
SLC11A2,
CPT1A,
EPHA4,
HADHB,
BID,
ATP5G2,
BAX,
MCL1,
BNIP3,
COASY,
RAB32,
PMAIP1,
LPIN1,
CASP8,
TOMM20,
MARC1,
LETMD1,
VPS13C,
MAVS,
SPG20,
TOMM5,
CISD2,
FAM73A,
SPATA18,
SLC44A1,
RTN4IP1,
BRI3BP,
CPT1B,
AKAP1,
BCL2L2,
BAD,
MOAP1,
MIEF2,
MYO19,
PHB2,
AIFM2,
PINK1,
MFF,
GPAM,
ABCB6,
TOMM22,
CISD1,
TOMM7,
PI4KB,
ACSL6,
BOK,
VDAC3,
SH3GLB1,
SAMM50
|
|
GO:0005742
|
CC
|
mitochondrial outer membrane translocase complex
|
A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments.
|
TOMM40,
TOMM20,
TOMM5,
PINK1,
TOMM22,
TOMM7
|
|
GO:0005743
|
CC
|
mitochondrial inner membrane
|
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
UQCRHL,
NDUFA4,
NME4,
NDUFAB1,
TIMM23,
UQCRQ,
UQCR11,
KMO,
MRPS12,
NDUFA1,
NDUFS4,
PRODH,
NDUFA2,
OPA1,
MRPS14,
TIMM17B,
NDUFS6,
MRPL33,
SLC25A12,
ATP5H,
ATP5L,
CLPX,
ABCA8,
NDUFB6,
NDUFB4,
NDUFB8,
NDUFA7,
LETM1,
SLC25A14,
NDUFA10,
CDS2,
AIFM1,
NDUFB10,
CYB5R3,
GOT2,
TYMS,
CYP11A1,
SLC25A5,
UQCRH,
CYC1,
CNP,
COX6C,
FGR,
COX5B,
MGST1,
HSPD1,
COX6A1,
SLC25A4,
CKMT1A,
HSD3B1,
COX6B1,
UQCRB,
CYP11B1,
COX7C,
SLC25A16,
CKMT2,
NDUFB7,
LGALS3,
ATP5J,
CYP11B2,
NDUFV2,
COX5A,
SDHB,
UQCRC2,
COX7B,
UCP1,
HSD3B2,
MAOB,
ABCD3,
ATP5D,
SDHA,
PRKAR2B,
UQCRC1,
PHB,
HMGCL,
ATP5C1,
CPOX,
MPV17,
STAT3,
MDH2,
ECI1,
CRAT,
GPD2,
VDAC2,
PLA2G4A,
UQCRFS1,
ATP5O,
IDH2,
MRPL19,
ACADVL,
PSEN1,
CPT1A,
GATM,
DAP3,
ALDH3A2,
MRPL12,
SLC25A1,
SUCLG1,
HCCS,
ALDH18A1,
HADHB,
UCP2,
UCP3,
NDUFV3,
ATP5I,
ROMO1,
MRPS25,
MRPS10,
MRPS5,
MRPS36,
MRPS21,
MRPS34,
CYCS,
SLC25A3,
DHODH,
PMPCA,
ICT1,
MRPL23,
PDK4,
NDUFA5,
HADH,
LETM2,
PGS1,
NDUFAF6,
TIMM50,
MRPL51,
OCIAD2,
SLC25A30,
THEM4,
ATAD3B,
NDUFAF5,
MARC1,
TTC19,
MRPL54,
MRPL14,
LETMD1,
SFXN4,
SLC25A26,
MRPL21,
MRPL55,
MRPL52,
NDUFA11,
MRPL41,
MICU2,
NDUFAF2,
GUF1,
MRPL50,
RDH13,
DUSP18,
MRPL30,
PTPMT1,
SLC25A43,
MRPS31,
CHCHD1,
SLC25A36,
DNAJC19,
MRPL38,
OMA1,
PTCD3,
MRPL48,
SLC25A44,
COQ2,
DHRS1,
MCCC1,
YME1L1,
TIMM17A,
PHB2,
SDHC,
NIPSNAP1,
MRPL34,
UQCC2,
MTG1,
NDUFAF3,
SLC25A23,
PINK1,
MRPL32,
MRPL4,
MRPL1,
MRPS26,
MRPL37,
SLC25A39,
SLC25A18,
GHITM,
MTG2,
MTHFD2L,
SFXN1,
MRPL44,
SLC25A19,
GPAM,
MRS2,
MRPL47,
ABCB6,
TIMMDC1,
MRPL40,
ABCB10,
MRPL17,
TOMM22,
ATAD3A,
MRPS18A,
AURKAIP1,
NDUFB11,
MRPL16,
SLC25A37,
MRPL35,
COQ3,
MRPL15,
NDUFAF4,
NDUFA13,
MRPL36,
SLC25A10,
UQCR10,
CRLS1,
SLC25A13,
BOK,
HIGD1A,
EXOG,
GSTK1,
MRPS28,
COQ4,
SAMM50,
TIMM10B,
DNAJC15,
SLC25A15,
MRPS18B,
MRPL42,
COX11
|
|
GO:0005744
|
CC
|
mitochondrial inner membrane presequence translocase complex
|
The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.
|
TIMM23,
TIMM17B,
TIMM50,
TIMM17A,
TIMM21
|
|
GO:0005746
|
CC
|
mitochondrial respiratory chain
|
The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.
|
UQCRH,
UQCRB,
COX7B,
UQCRC1,
COX7B2,
NDUFA13
|
|
GO:0005747
|
CC
|
mitochondrial respiratory chain complex I
|
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
|
NDUFS8,
NDUFA4,
NDUFAB1,
NDUFA1,
NDUFS4,
NDUFA2,
NDUFS2,
NDUFS6,
NDUFB6,
NDUFB4,
NDUFB8,
NDUFA7,
NDUFA10,
NDUFB10,
NDUFB7,
NDUFV2,
NDUFS1,
SNCA,
NDUFV3,
NDUFA5,
NDUFA11,
NDUFB11,
NDUFA13
|
|
GO:0005749
|
CC
|
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
|
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.
|
SDHB,
SDHA,
SDHC
|
|
GO:0005750
|
CC
|
mitochondrial respiratory chain complex III
|
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.
|
PMPCB,
UQCRB,
UQCRC2,
UQCRC1,
UQCRFS1,
UQCC3,
UQCR10,
BCS1L
|
|
GO:0005751
|
CC
|
mitochondrial respiratory chain complex IV
|
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
|
NDUFA4,
COX5B,
COX6A1,
COX5A,
NMES1
|
|
GO:0005753
|
CC
|
mitochondrial proton-transporting ATP synthase complex
|
A proton-transporting ATP synthase complex found in the mitochondrial membrane.
|
ATP5H,
ATP5L,
ATP5J,
ATP5D,
PPIF,
ATP5C1,
ATP5O,
ATP5G3,
ATP5E,
ATP5I,
ATP5G2
|
|
GO:0005757
|
CC
|
mitochondrial permeability transition pore complex
|
A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D).
|
BAX
|
|
GO:0005758
|
CC
|
mitochondrial intermembrane space
|
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
|
HAX1,
NME4,
TIMM23,
TRIAP1,
OPA1,
AIFM1,
LYN,
FGR,
HSD3B1,
COX6B1,
NDUFB7,
DTYMK,
HSD3B2,
NDUFS1,
CPOX,
STAR,
GATM,
SUOX,
THOP1,
GFER,
CMC4,
BLOC1S1,
CYCS,
COX17,
COX19,
THEM4,
MICU2,
PNPT1,
CHCHD10,
CEP89,
UQCC2,
CHCHD5,
CHCHD7,
PINK1,
NLN,
PANK2,
TXNIP,
SDHAF3,
COA4,
PRELID1,
REXO2,
TIMM10B,
CHCHD2
|
|
GO:0005759
|
CC
|
mitochondrial matrix
|
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
TK2,
NDUFS8,
NME4,
NDUFAB1,
KIAA0391,
PRODH,
IDH3B,
PTCD1,
NDUFS2,
PMPCB,
CLPX,
GLS,
NDUFA10,
FARS2,
ETHE1,
GSR,
GOT2,
NR3C1,
SOD2,
TP53,
TYMS,
ALDH2,
CYP11A1,
PCCA,
GPX1,
FH,
PDHA1,
DLD,
FDX1,
DLAT,
HSPD1,
PDHB,
DBT,
PC,
BCKDHA,
MTHFD2,
CREB1,
AGXT,
BCKDHB,
ME2,
GCSH,
DTYMK,
AK4,
NDUFS1,
ATP5D,
ECHS1,
PPIF,
ALDH1B1,
HIBADH,
HSPA1L,
HMGCL,
ATP5C1,
NUDT1,
DLST,
MDH2,
ECI1,
TSFM,
ACADSB,
IDH2,
ALDH7A1,
HARS2,
ACADVL,
MTHFS,
SUOX,
SUCLG1,
ATXN3,
OXCT1,
ATP5E,
ABCE1,
HSPE1,
BLOC1S1,
ABAT,
TFAM,
OGDH,
ALDH6A1,
SSBP1,
RNASEL,
RAD51,
C1QBP,
MCL1,
PMPCA,
COASY,
AUH,
ICT1,
FASTK,
LARS2,
KARS,
PDK1,
ERBB4,
ETFDH,
FXN,
PDK4,
DECR1,
CLPP,
HAGH,
ME3,
PCK2,
HADH,
DGUOK,
TRMT5,
ALDH1L2,
ACSM3,
LACTB2,
EARS2,
PITRM1,
THEM4,
PDSS1,
IBA57,
SDHAF4,
HIBCH,
FDX1L,
MTHFD1L,
PARS2,
PDSS2,
PHYKPL,
MMAA,
CARKD,
ADHFE1,
ETFBKMT,
SUPV3L1,
CCAR2,
PPM1K,
GUF1,
GADD45GIP1,
NUBPL,
GPT2,
MALSU1,
MMAB,
PRIMPOL,
MCEE,
TRNT1,
TEFM,
GFM1,
MCCC1,
PEO1,
MTERF1,
HSD17B10,
TXN2,
MIPEP,
ACO2,
ELAC2,
UQCC2,
MTG1,
ALKBH7,
ISCA1,
NUDT9,
PPA2,
MTG2,
DUSP21,
MTHFD2L,
GRPEL1,
MCCC2,
SDHAF3,
GLRX2,
ACSS1,
ABHD10,
COQ3,
PDP1,
SUCLA2,
AASS,
DMGDH,
AK3,
SARDH,
DIMT1,
LIPT1,
PIN4,
GSTK1,
ACOT9,
REXO2,
PAM16
|
|
GO:0005760
|
CC
|
gamma DNA polymerase complex
|
A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA.
|
DNA2,
POLG
|
|
GO:0005761
|
CC
|
mitochondrial ribosome
|
A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.
|
MRPS12,
MRPS14,
NDUFA7,
MRPL51,
GADD45GIP1,
CHCHD1,
MRPL48,
MRPL34,
MRPL57,
MTG1,
MRPL32,
MRPL37,
MTG2,
MRPL40,
MRPL35
|
|
GO:0005762
|
CC
|
mitochondrial large ribosomal subunit
|
The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
|
MRPL33,
MRPL19,
MRPL12,
ICT1,
MRPL23,
MRPL51,
MRPL21,
MRPL55,
MRPL52,
MRPL41,
MRPL32,
C12orf65,
MRPL47,
MRPL17,
MRPL16,
MRPL15,
MRPL36
|
|
GO:0005763
|
CC
|
mitochondrial small ribosomal subunit
|
The smaller of the two subunits of a mitochondrial ribosome.
|
MRPS12,
MRPS14,
DAP3,
MRPS5,
MRPS36,
MRPS21,
MRPS31,
MRPS26,
MRPS18A,
MRPS28,
MRPS2,
MRPS18B,
MRPL42
|
|
GO:0005764
|
CC
|
lysosome
|
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
TMEM150B,
RNASET2,
TPP1,
NPC1,
STX7,
RAMP3,
VAMP4,
CLN5,
BCL10,
ADA,
ASS1,
CST3,
LDLR,
IL1B,
HLA-DRA,
MPO,
CTSD,
ADRB2,
PSAP,
CTSL,
CTSB,
STS,
CTSH,
RNASE2,
GAA,
LAMP1,
ACE,
LAMP2,
HLA-DOB,
TYR,
ARSA,
ARSB,
IFNAR1,
GJA1,
TNFAIP3,
CTSS,
PRDX6,
USP6,
SNCA,
LIPA,
CTSK,
SLC11A1,
TSC2,
LRBA,
PPT1,
RAB7A,
RAB9A,
RAB27A,
SGSH,
ARSD,
CTSC,
NAGLU,
GALC,
SNX16,
CXCR4,
NPC2,
LRP2,
CTBS,
CD164,
HYAL2,
ANK3,
CHIT1,
CLN3,
LAPTM5,
NBR1,
TRIP10,
TMEM97,
MARCH8,
LAMTOR1,
RAB12,
DRAM2,
KIAA1324,
TMEM150A,
DRAM1,
RNF152,
PCSK9,
SLC38A9,
FLCN,
ENGASE,
TPCN2,
WDR48,
MARCH1,
GLMP,
ABCA5,
GGH,
HPS1,
ARRDC3,
C9orf72,
CCDC115,
ANKRD27,
FNBP1,
NEU1,
SYT11,
BBC3,
TMEM59,
AP5M1,
RRAGC,
ATP13A2,
HPS4,
RRAGD,
TMEM9,
CTSZ,
CTSF,
PCYOX1,
EPDR1,
PPT2,
HPSE,
AP3M1,
MYO5A,
CPQ
|