GO:0051260

BP

protein homooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

TOR1A, TNFSF11, SLC22A1, CLDN3, CHMP2A, SPAG9, PEX14, POLQ, FLOT1, CLDN1, BCL10, PEX11B, CRYAB, PRNP, VWF, NPM1, ANXA6, HMOX1, ALAD, IDE, PAM, SYT1, TGM2, FAS, PLN, STOM, SLC6A1, RBMX, CPT1A, VCP, BID, CAV1, AKR1C1, RAD51, BAX, KCNA1, TAF10, RIPK1, KCNC3, DPYSL3, ITPR3, ADIPOQ, CLPP, TOR2A, COLEC12, KCTD11, ATL3, OLFM4, KCTD1, CEP57, SCUBE1, SCUBE3, TOR2A, NLGN1, MUC20, KCTD6, ATL2, KCNG3, PNPT1, KCNV2, KCTD13, KCTD12, KCTD7, PEO1, P2RX4, NUP58, C1QTNF1, TMEM120A, MFF, EHD4, KCTD10, CHMP4B, SMARCAD1, ECT2, GOPC, EHD3, SPAST, KCNG1, PRND

GO:0051261

BP

protein depolymerization

The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein.

VPS4B

GO:0051262

BP

protein tetramerization

The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.

NUDT21, HMGCR, TP53, FH, IGF1R, CCL5, ADSL, SHMT1, HMGCL, MTMR2, KCNC3, UXS1, TRPM7, DHRS4, TRPM6, AASS

GO:0051270

BP

regulation of cellular component movement

Any process that modulates the frequency, rate or extent of the movement of a cellular component.

B4GALT1, ARAP1

GO:0051271

BP

negative regulation of cellular component movement

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component.

ACTN4, ACTN1, SP100, CDKN1B, TGFBR3

GO:0051272

BP

positive regulation of cellular component movement

Any process that activates or increases the frequency, rate or extent of the movement of a cellular component.

ACTN4, LYN, ETS1, VEGFA, STMN1, TGFBR1, BCL6, ADAM17, PDPN

GO:0051276

BP

chromosome organization

A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.

SMCHD1, PTTG1, MYC, SFPQ, YY1, GEM, CDCA8, CENPW, RAD54L, PELO

GO:0051279

BP

regulation of release of sequestered calcium ion into cytosol

Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.

LYN, CORO1A, ANK2, PRKD1, UBASH3B

GO:0051280

BP

negative regulation of release of sequestered calcium ion into cytosol

Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.

TGFB1

GO:0051281

BP

positive regulation of release of sequestered calcium ion into cytosol

Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.

F2, CAPN3, F2R, SRI, SNCA, TRPC1, BAX, AKAP6, CEMIP, GPER1

GO:0051282

BP

regulation of sequestering of calcium ion

Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.

SLC25A23

GO:0051284

BP

positive regulation of sequestering of calcium ion

Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.

RYR2

GO:0051289

BP

protein homotetramerization

The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.

ACACB, GLS, ALDOA, SOD2, TK1, FBP1, IDE, PFKL, GPX3, MIP, CTH, SHMT1, ACTN2, DHPS, PPAT, CRYZ, GOLGA2, KCNJ12, RYR3, DECR1, CRTC3, DCXR, TRPV1, HM13, SYT11, DCTPP1, ACOT13, EVL, SAMHD1

GO:0051290

BP

protein heterotetramerization

The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.

INSR, ANXA2, RRM1, RRM2, S100A10, HIST1H4A, HIST1H3D, PDSS1, PDSS2, NLGN1, NUP58, FARSA

GO:0051291

BP

protein heterooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

TMEM120B, CLDN3, CHMP2A, CLDN1, BCL10, IDE, JUP, MAT2A, YWHAB, CTNNA1, LIMS1, GLRB, GRB2, HBB, HBA1, FADD, ILK, BIRC3, SQSTM1, RIPK1, ITPR3, CASP8, TRADD, SEPT7, MAGI2, SCUBE3, MCCC1, TMEM120A, MCCC2, CAB39

GO:0051292

BP

nuclear pore complex assembly

The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex.

NUP153, NUP107, NUP93, TMEM170A, AHCTF1, NUP205, NDC1, RTN4

GO:0051293

BP

establishment of spindle localization

The directed movement of the spindle to a specific location in the cell.

DYNC1H1

GO:0051294

BP

establishment of spindle orientation

Any process that set the alignment of spindle relative to other cellular structures.

SPAG5

GO:0051295

BP

establishment of meiotic spindle localization

The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs.

MYH9, FMN2

GO:0051297

BP

centrosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.

PPP1R12A, HAUS5, PLK1, GOLGA2, CKAP5, KIAA0101, PCM1, CROCC, HAUS6, SDCCAG8, CEP120, HAUS1, HAUS7, HAUS4, HAUS2, UXT, SSX2IP

GO:0051298

BP

centrosome duplication

The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.

ARHGEF10, ROCK2, CEP152, CDK2, BRCA2, PKD2, STIL, TUBGCP3, NDE1

GO:0051299

BP

centrosome separation

The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.

NEK2, CNTROB

GO:0051301

BP

cell division

The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

STRA13, CDC7, WASL, UBE2C, NDC80, AURKA, CETN3, BIRC5, OIP5, ZNF207, BUB1, BUB3, ENSA, RAD21, CCNT1, BUB1B, CCNT2, PRPF40A, TACC1, CDC123, RNF8, HAUS5, CCNB2, ZWINT, TNKS, SMC2, LATS1, PTTG1, CCNE2, NR3C1, GNAI2, RB1, CDK1, TUBB, GNAI3, CDK4, TPR, CCNB1, RCC1, LIG1, CCNA2, CDK2, CCND2, CCND3, WEE1, CDC25A, CDC25B, CDC25C, CKS2, PPP1CC, CCNF, NCAPD3, BRCC3, CSNK1A1, CENPF, CDK7, KNTC1, ANXA11, NEK2, NEK3, NEK4, CCNG1, KIF11, HMGA2, IST1, TERF1, ARPP19, CKS1B, PPP1CA, PPP1CB, GNAI1, DYNLT1, UBE2I, TUBA1B, CCNA1, CDK3, CDK6, CDK5, CENPE, CENPC, NSUN2, CDC20, MAD2L1, ITGB3BP, CKAP5, NEDD9, SMC1A, NCAPH, FAM175B, SEPT2, NCAPD2, KIF14, MAPRE2, MAPRE1, PKN2, CCNG2, UBE2S, PDS5A, ERCC6L, CDCA8, SGOL2, CENPW, SGOL1, CDCA2, REEP3, MIS18BP1, PSRC1, BORA, TUBA1A, MAEA, HAUS6, WAPL, CENPV, NCAPG2, ANKLE2, KIF18B, TEX14, SKA3, SIRT2, SMC5, SPG20, APITD1, SPC24, PAPD5, NUP43, NUP37, CASC5, MPLKIP, NEK9, SKA2, ARHGEF2, SKA1, ARL8A, HAUS1, ANAPC16, SPDL1, SEH1L, CDCA5, MASTL, SENP5, BOD1, NSL1, ZFYVE19, MARK4, NEK1, KIF20B, SPAG5, SETDB2, CDCA3, KIF2C, CDC6, CIB1, HAUS7, VRK1, NCAPG, PELO, FAM64A, KATNB1, TIPIN, KIFC1, PARD6B, NUF2, LRRCC1, USP44, ANAPC1, TRIOBP, DSN1, FAM83D, HAUS4, ZWILCH, SPC25, CENPJ, PARD6A, KMT5A, LATS2, HELLS, PDS5B, SMC4, ARL8B, HAUS2, NDE1, MIS18A, KLHL42, FBXL7, CDC23, ANAPC5, ANAPC4, FBXO5, TPX2, FZR1, ANAPC10, CDC14A, TIMELESS, MAPRE3, SMC3, RUVBL1, KNSTRN, MAD1L1

GO:0051302

BP

regulation of cell division

Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.

RACK1, KIF18B, CIB1

GO:0051303

BP

establishment of chromosome localization

The directed movement of a chromosome to a specific location.

NDEL1, NDE1

GO:0051304

BP

chromosome separation

The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).

TTK, NCAPD3, NCAPD2, SMARCAD1

GO:0051306

BP

mitotic sister chromatid separation

The process in which sister chromatids are physically detached from each other during mitosis.

PPP2R1A, TEX14

GO:0051307

BP

meiotic chromosome separation

The process in which chromosomes are physically detached from each other during meiosis.

ESPL1

GO:0051310

BP

metaphase plate congression

The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle.

MEIOC, NDC80, CENPF, GEM, CENPE, KIF22, CENPQ, KIF2C, FAM83D

GO:0051315

BP

attachment of mitotic spindle microtubules to kinetochore

The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex as part of mitotic metaphase plate congression.

NDC80, CENPE, SEH1L, CHAMP1, KIF2C, MAD1L1

GO:0051321

BP

meiotic cell cycle

Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.

BUB3, NBN, H2AFX, NEK2, PIWIL4, SIRT2, MNS1, RSPH1, PSMC3IP, EXO1, SPIN1

GO:0051343

BP

positive regulation of cyclic-nucleotide phosphodiesterase activity

Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.

CALM2, RACK1

GO:0051344

BP

negative regulation of cyclic-nucleotide phosphodiesterase activity

Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.

AIP, MAPK7, RGN

GO:0051345

BP

positive regulation of hydrolase activity

Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.

APOA1, GM2A

GO:0051346

BP

negative regulation of hydrolase activity

Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.

SERPINA5, NOS3, LEPR

GO:0051347

BP

positive regulation of transferase activity

Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor.

RPS2

GO:0051349

BP

positive regulation of lyase activity

Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.

FXN

GO:0051350

BP

negative regulation of lyase activity

Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.

PHPT1

GO:0051351

BP

positive regulation of ligase activity

Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.

XRCC4, MID1IP1

GO:0051353

BP

positive regulation of oxidoreductase activity

Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.

CCS, ABL2

GO:0051354

BP

negative regulation of oxidoreductase activity

Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.

HP, MT3, HDAC6

GO:0051365

BP

cellular response to potassium ion starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions.

JUN, PCK1

GO:0051382

BP

kinetochore assembly

The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

STRA13, CENPA, CENPF, CENPE, CENPC, CENPW, APITD1, CENPH

GO:0051383

BP

kinetochore organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

SMC2, CENPH, SMC4

GO:0051384

BP

response to glucocorticoid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

KRAS, TNF, APOA2, BGLAP, S100B, TYMS, ALPL, IL6, SPARC, BCL2, HSPD1, ANXA3, ALAD, CPN1, AREG, PFKFB1, IGFBP2, IL1RN, SDC1, PAM, AGXT, MDK, BMP6, IL10, FAS, DUSP1, ADM, PTGS2, PTGDS, HNMT, UCP3, HSD11B2, PAPPA, ADAM9, ADIPOQ, CDO1, PPARGC1B, TPH2, BAD

GO:0051385

BP

response to mineralocorticoid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance.

KRAS, CTGF

GO:0051386

BP

regulation of neurotrophin TRK receptor signaling pathway

Any process that modulates the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.

SLC9A6, DOK5

GO:0051387

BP

negative regulation of neurotrophin TRK receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.

SPRY2, SPRY1, AGT, AGTR2

GO:0051388

BP

positive regulation of neurotrophin TRK receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.

PPP2R5B

GO:0051389

BP

inactivation of MAPKK activity

Any process that terminates the activity of the active enzyme MAP kinase kinase (MAPKK).

IGF1R

GO:0051402

BP

neuron apoptotic process

Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.

TNFRSF21, AIFM1, GAPDH, APP, RB1, BCL2, ERBB3, PSEN1, ATN1, BID, CDK5, BAX, BNIP3, NAE1, SIAH1, PIGT, FAM162A, BOK

GO:0051403

BP

stress-activated MAPK cascade

A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.

MAP2K7, MAP3K7, AGT, CRYAB, UBC, NFKB1, MAP3K8, RPS27A, UBA52, SKP1, CCM2, RBM4, TAOK2, BTRC

GO:0051409

BP

response to nitrosative stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.

GCLC, GCLM, DUSP6

GO:0051410

BP

detoxification of nitrogen compound

Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.

MARC1

GO:0051412

BP

response to corticosterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.

FOS, TH, FOSL1, TRH, MAOB, CDKN1A, STAR, FOSB, CALM2

GO:0051414

BP

response to cortisol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.

SLIT2, CAD, IGFBP7

GO:0051415

BP

interphase microtubule nucleation by interphase microtubule organizing center

The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation.

MZT1, TUBGCP3

GO:0051436

BP

negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle.

PSMD11, PSMD12, UBE2C, PSMD3, BUB3, BUB1B, PSMD10, CDK1, UBC, CCNB1, PSMC3, PSMB1, CDK2, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, CDC27, PSMC2, PSMB10, PSMC4, PSMB3, PSMD7, UBE2E1, PSME3, PSMC1, PSMC6, RPS27A, UBA52, CDC20, PSMD2, MAD2L1, ANAPC16, ANAPC1, CDC23, ANAPC5, ANAPC4, FBXO5, FZR1, ANAPC10

GO:0051437

BP

positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition

Any process that activates, maintains or increases the rate of ubiquitin ligase activity that contributes to the regulation of the mitotic cell cycle phase transition.

PSMD11, PSMD12, UBE2C, PSMD3, BUB3, BUB1B, PSMD10, CDK1, UBC, CCNB1, PSMC3, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, CDC27, PSMC2, PSMB10, PSMC4, PSMB3, PSMD7, UBE2E1, PLK1, PSME3, PSMC1, PSMC6, RPS27A, UBA52, SKP1, CDC20, PSMD2, MAD2L1, PSME4, ANAPC16, ANAPC1, CDC23, ANAPC5, ANAPC4, FBXO5, FZR1, ANAPC10, BTRC

GO:0051438

BP

regulation of ubiquitin-protein transferase activity

Any process that modulates the frequency, rate or extent of ubiquitin transferase activity.

FEM1A, FEM1B, BAG5

GO:0051439

BP

regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle.

UBE2C, CDK1, CCNB1, CDK2, CDC27, UBE2E1, PLK1, CDC20, ANAPC16, ANAPC1, CDC23, ANAPC5, ANAPC4, FBXO5, FZR1, ANAPC10

GO:0051443

BP

positive regulation of ubiquitin-protein transferase activity

Any process that activates, maintains or increases the rate of ubiquitin transferase activity.

AXIN1, PLK1, ARRDC4, DCUN1D4, ARRDC3, DCUN1D1, TRIB3, PINK1, STUB1

GO:0051444

BP

negative regulation of ubiquitin-protein transferase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity.

SMAD7, PSEN1, BAG5

GO:0051445

BP

regulation of meiotic cell cycle

Any process that modulates the rate or extent of progression through the meiotic cell cycle.

ASPM

GO:0051446

BP

positive regulation of meiotic cell cycle

Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.

INSR

GO:0051447

BP

negative regulation of meiotic cell cycle

Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.

NPR2, DUSP1

GO:0051450

BP

myoblast proliferation

The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.

IGF1, GPX1, HGF, ATOH8

GO:0051451

BP

myoblast migration

The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.

ITGB1BP1, THBS4, PLEKHO1, NET1

GO:0051452

BP

intracellular pH reduction

Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.

GPR89A, GPR89B

GO:0051453

BP

regulation of intracellular pH

Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.

CA2, SLC4A2, SLC26A2, SLC4A8, SLC26A11, SLC9A6, CHP1, SLC26A1, SLC9A2, SLC4A4

GO:0051454

BP

intracellular pH elevation

Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion.

CFTR

GO:0051456

BP

attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation

The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs.

DSN1

GO:0051457

BP

maintenance of protein location in nucleus

Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus.

SUPT7L, BCL3, SKP1, MORC3

GO:0051461

BP

positive regulation of corticotropin secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell.

RAB8B, GHRL, APLN

GO:0051463

BP

negative regulation of cortisol secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell.

PTPN11

GO:0051464

BP

positive regulation of cortisol secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell.

GAL, GHRL

GO:0051466

BP

positive regulation of corticotropin-releasing hormone secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell.

TNFSF11, APLN

GO:0051480

BP

regulation of cytosolic calcium ion concentration

Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.

F2, PRKACA, CALB2, PLN, TRPC1, CAV1, CLN3, TMEM178A, RYR2, GPER1, TRPC6

GO:0051481

BP

negative regulation of cytosolic calcium ion concentration

Any process that decreases the concentration of calcium ions in the cytosol.

KCNK3, DRD2, ATP1A2, GTF2I, SMAD3, RYR3

GO:0051482

BP

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol.

EDN1, S1PR1, TGM2, F2R, HTR2C, AGTR1, KISS1

GO:0051489

BP

regulation of filopodium assembly

Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

GAP43, RAB5A, CDC42, FMR1, MYO10

GO:0051490

BP

negative regulation of filopodium assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

CAPZB, PRKCD

GO:0051491

BP

positive regulation of filopodium assembly

Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

WASL, RALA, RHOQ, TGFBR1, FMR1, DPYSL3, FSCN1, FNBP1L, NLGN1, ARAP1

GO:0051492

BP

regulation of stress fiber assembly

Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.

ROCK2, PIK3R1, PTGER4, MKKS

GO:0051493

BP

regulation of cytoskeleton organization

Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.

S100A8, S100A9, STMN1, MAPK3, MAPK1, DYNLT1, PTK2, NEXN, ARHGEF5, CRIPAK, STMN3

GO:0051495

BP

positive regulation of cytoskeleton organization

Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.

SORBS3, PLXNA3

GO:0051496

BP

positive regulation of stress fiber assembly

Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.

ITGB1BP1, ARHGEF10, SORBS3, APOA1, PFN1, TPM1, CTGF, SDC4, NF2, TGFBR1, PPM1F, S100A10, RHOA, RAC1, SMAD3, ARHGEF5, LRRC16A, SFRP1, PPM1E, RGCC, NOX4, EVL, FHOD1

GO:0051497

BP

negative regulation of stress fiber assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.

ARHGAP6, PFN1, S1PR1, PHLDB2, ARAP1, DLC1, INPP5K, TMEFF2, WASF2

GO:0051503

BP

adenine nucleotide transport

The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

SLC25A23

GO:0051531

BP

NFAT protein import into nucleus

The directed movement of NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors, from the cytoplasm into the nucleus. NFAT proteins are dephosphorylated in the cytoplasm by activated calcineurin, which leads to their translocation across the nuclear membrane.

PIK3R1

GO:0051533

BP

positive regulation of NFAT protein import into nucleus

Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus.

TNF, PPP3CA, AKAP6, CHERP, SPPL3

GO:0051534

BP

negative regulation of NFAT protein import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus.

GSK3B, MAPK7, DYRK2

GO:0051541

BP

elastin metabolic process

The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue.

HIF1A

GO:0051545

BP

negative regulation of elastin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin.

HBEGF

GO:0051546

BP

keratinocyte migration

The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another.

KRT16, PPARD, FERMT1

GO:0051549

BP

positive regulation of keratinocyte migration

Any process that activates or increases the frequency, rate or extent of keratinocyte migration.

MMP9, FGF7, ADAM9, HAS2, HBEGF, EPB41L4B

GO:0051552

BP

flavone metabolic process

The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone).

PPARGC1A

GO:0051560

BP

mitochondrial calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.

ANXA6, MICU2

GO:0051561

BP

positive regulation of mitochondrial calcium ion concentration

Any process that increases the concentration of calcium ions in mitochondria.

TGM2, BCAP31, RAP1GDS1, MICU2, MCUR1

GO:0051562

BP

negative regulation of mitochondrial calcium ion concentration

Any process that decreases the concentration of calcium ions in mitochondria.

MICU2