GO:0050995

BP

negative regulation of lipid catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.

INS, TNF, IL1B, APOA2, APOC1, APOC3, ADORA1, PDE3B, CRTC3, C7orf55

GO:0050996

BP

positive regulation of lipid catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.

IL1B, APOA2, APOA5

GO:0050999

BP

regulation of nitric-oxide synthase activity

Any process that modulates the activity of the enzyme nitric-oxide synthase.

WASL, LYPLA1, DDAH1, DDAH2, EGFR, IL1B, HSP90AA1, ACVR2A, NOS3, AKT1, LEP, CALM2, CAV1, NOSTRIN, CYGB

GO:0051000

BP

positive regulation of nitric-oxide synthase activity

Any process that activates or increases the activity of the enzyme nitric-oxide synthase.

DHFR, KRAS, INS, APOE, NPR3, AKT1, HTR2B, AGTR2, CALM2, HIF1A, SCARB1

GO:0051001

BP

negative regulation of nitric-oxide synthase activity

Any process that stops or reduces the activity of the enzyme nitric-oxide synthase.

CNR1, ATP2B4, CAV1

GO:0051005

BP

negative regulation of lipoprotein lipase activity

Any process that stops or reduces the activity of the enzyme lipoprotein lipase.

APOC1, APOC3

GO:0051006

BP

positive regulation of lipoprotein lipase activity

Any process that activates or increases the activity of the enzyme lipoprotein lipase.

APOA1, APOH, NR1H2, NR1H3, APOA5, ABHD5, LMF1

GO:0051013

BP

microtubule severing

The process in which a microtubule is broken down into smaller segments.

KATNB1, KATNAL1, SPAST

GO:0051014

BP

actin filament severing

The process in which an actin filament is broken down into smaller filaments.

DSTN

GO:0051016

BP

barbed-end actin filament capping

The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.

RDX, CAPG, CAPZB, CAPZA1, TWF1, EPS8, TWF2, TRIOBP

GO:0051017

BP

actin filament bundle assembly

The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.

RHOD, ACTN4, ACTN1, LCP1, EZR, CDC42, EPS8, DPYSL3, NEDD9, PLS1, FSCN1, PAWR, CORO1B, LIMA1, BAIAP2L1

GO:0051023

BP

regulation of immunoglobulin secretion

Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell.

TNF, CD40LG

GO:0051024

BP

positive regulation of immunoglobulin secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.

IL33, RBP4, IL6, HLA-E, XBP1, TNFSF4, STX4

GO:0051025

BP

negative regulation of immunoglobulin secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of immunoglobulins from a cell.

IL33

GO:0051026

BP

chiasma assembly

The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids.

UBE2B

GO:0051028

BP

mRNA transport

The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

MYO1C, IGF2BP3, XPO1, KIF5C, TNKS, HNRNPA1, ZFP36, LRPPRC, HNRNPA3, SEC13, FMR1, ZFP36L1, SLBP, NCBP3, SUPT6H, AHCTF1, KHSRP, QKI, EIF5A2, UPF3A, PARP11, G3BP2, NPIPA1, IGF2BP2

GO:0051036

BP

regulation of endosome size

Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis.

RAB5A, ALS2

GO:0051042

BP

negative regulation of calcium-independent cell-cell adhesion

Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion.

BMP2

GO:0051044

BP

positive regulation of membrane protein ectodomain proteolysis

Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.

NRDC, TNF, IL1B, APOE, FURIN, TNFRSF1B, ADAM8, GPLD1, ADAM9, SNX33, SNX9

GO:0051045

BP

negative regulation of membrane protein ectodomain proteolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.

TIMP1, TIMP2, IL10, TIMP3

GO:0051046

BP

regulation of secretion

Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.

MYO6

GO:0051047

BP

positive regulation of secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.

GPLD1

GO:0051048

BP

negative regulation of secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.

ERBB3, NPY2R, NRG1

GO:0051053

BP

negative regulation of DNA metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

GPER1

GO:0051054

BP

positive regulation of DNA metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.

PFN1, ANXA3

GO:0051055

BP

negative regulation of lipid biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

STK11, SERPINA12, GPER1

GO:0051056

BP

regulation of small GTPase mediated signal transduction

Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.

RHOD, ARHGAP33, ARHGAP6, PLEKHG5, FAM13A, A2M, BCR, RAC2, VAV1, CHN1, RHOQ, GDI1, ARHGAP25, TSC2, GDI2, ARHGDIA, ARHGDIB, RAC3, CDC42, RHOA, RHOB, RAC1, OCRL, SOS1, SOS2, AKAP13, ABR, TIAM1, ARHGAP5, MYO9B, ARHGEF7, ARHGAP19, RALBP1, TRIP10, ITSN1, ARHGAP31, RALGAPA2, AMOT, ARHGAP29, ARHGEF16, RALGAPA1, ARHGAP11A, SYDE1, RHOU, ARHGAP22, NET1, SRGAP1, ARHGAP30, FGD2, RALGAPB, TAGAP, ARHGAP24, ARHGAP18, DEPDC1B, ARAP3, ARAP2, STARD8, ARHGEF2, FGD4, ARAP1, DLC1, RACGAP1, RHOJ, PLEKHG2, ECT2, ARHGEF4, ARHGEF3, FAM13B, ARHGAP23, ARHGAP20, SIPA1L2, VAV3, ARHGAP26, STARD13

GO:0051057

BP

positive regulation of small GTPase mediated signal transduction

Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.

SOS1, SOS2

GO:0051058

BP

negative regulation of small GTPase mediated signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.

SLIT2

GO:0051066

BP

dihydrobiopterin metabolic process

The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions.

QDPR

GO:0051068

BP

dihydrolipoamide metabolic process

The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor.

DLD

GO:0051081

BP

nuclear envelope disassembly

The controlled breakdown of the nuclear envelope in the context of a normal process.

NDEL1

GO:0051083

BP

de novo' cotranslational protein folding

The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.

HSPA14

GO:0051084

BP

de novo' posttranslational protein folding

The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis.

SELENOF, UGGT1

GO:0051085

BP

chaperone mediated protein folding requiring cofactor

The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.

TOR1A, CD74, HSPD1, DNAJB1, HSPE1, TOR2A, TOR2A, HSPH1, ERO1A

GO:0051086

BP

chaperone mediated protein folding independent of cofactor

The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release.

CCT2

GO:0051088

BP

PMA-inducible membrane protein ectodomain proteolysis

The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist.

ADAM10, ADAM17, ADAM9

GO:0051089

BP

constitutive protein ectodomain proteolysis

The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands.

ADAM10

GO:0051090

BP

regulation of sequence-specific DNA binding transcription factor activity

Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

FOS, JUN, HMOX1, MAPK3, MAPK1, SYK, MAPK8, MAPK9, MAPK14, SGK3, FANCD2

GO:0051091

BP

positive regulation of sequence-specific DNA binding transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

TRIM38, PLPP3, TNFSF11, KDM1A, JAK2, LRP5, LRP6, TRIM37, TNF, IL1B, ESR1, IL6, EDN1, WNT2, KIT, ANXA3, JUP, FOSL1, TCF3, IL10, AKT1, CTNNB1, PPARG, SMARCA4, GTF2A2, CEBPG, HDAC4, PTEN, NDP, PPP3CA, EP300, ARHGEF5, TRIM26, TRIM14, TRIM25, ARID5B, PPP2R5B, TAF12, MAVS, PPARGC1B, TRIM22, JMY, ESR2, PHB2, TRIM62, PINK1, TRIM34, PRKD2, TRIM8, HIPK2, RGCC, BEX1, PPARGC1A, FZD4, PYCARD, HDAC5, TNFRSF11A

GO:0051092

BP

positive regulation of NF-kappaB transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

TLR4, TRIM38, TNFSF11, TLR3, CFLAR, IRAK2, MAP3K13, MAP3K7, RIPK2, GREM1, TLR2, TRIM13, RPS6KA5, TRIM37, BCL10, AGT, KRAS, TGFB1, INS, TNF, IL1B, AMH, NTRK1, ITGB2, S100A8, ICAM1, PRKCB, S100A9, NPM1, UBC, HSPA1A, HSPA1B, AR, CLU, NFKB1, CAPN3, CD40LG, CTH, WNT5A, PRKCI, IRAK1, MTPN, TIRAP, RPS27A, UBA52, ADAM8, RELA, PRKCQ, TRAF1, UBE2V1, RIPK1, TRIM14, TRIM25, PRKD1, TRADD, TAB1, LRRFIP1, MTDH, ERC1, TRIM22, TAB3, RHEBL1, ARHGEF2, CIB1, TRIM62, PRKD2, TRIM8, IL1RAP, SPHK1, PYCARD, IRAK3, TNFRSF11A

GO:0051096

BP

positive regulation of helicase activity

Any process that activates or increases the activity of a helicase.

MSH3, MSH2, MSH6, SSBP1, POT1

GO:0051097

BP

negative regulation of helicase activity

Any process that stops or reduces the activity of a helicase.

TP53

GO:0051098

BP

regulation of binding

Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.

TGFB1, SMAD3, SMAD4, SMAD2

GO:0051099

BP

positive regulation of binding

Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.

ANXA2, PON1, S100A10, DPH3

GO:0051100

BP

negative regulation of binding

Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.

CYP2D6

GO:0051101

BP

regulation of DNA binding

Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).

TGFB1, BCL3, HJURP

GO:0051103

BP

DNA ligation involved in DNA repair

The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair.

HMGB1, PARP1, HMGB2, XRCC4, PARP2

GO:0051106

BP

positive regulation of DNA ligation

Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.

HMGB1, RAD51

GO:0051122

BP

hepoxilin biosynthetic process

The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology.

ALOX15

GO:0051123

BP

RNA polymerase II transcriptional preinitiation complex assembly

The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.

MED6, GTF2A2, TAF11, TAF9B, DACH1

GO:0051124

BP

synaptic growth at neuromuscular junction

The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates.

APP

GO:0051126

BP

negative regulation of actin nucleation

Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.

CORO1A, ARPIN

GO:0051127

BP

positive regulation of actin nucleation

Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.

WIPF3

GO:0051128

BP

regulation of cellular component organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

COL5A1, STK38L

GO:0051131

BP

chaperone-mediated protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.

PFDN6, APCS, HSP90AA1, HSPD1, CLU, HSPA4, CCT2, BBS12, BBS10, MKKS, THEG

GO:0051135

BP

positive regulation of NK T cell activation

Any process that activates or increases the frequency, rate or extent of natural killer T cell activation.

IL12A, HSPH1

GO:0051138

BP

positive regulation of NK T cell differentiation

Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation.

AP3D1, TGFBR2, ZBTB16

GO:0051142

BP

positive regulation of NK T cell proliferation

Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation.

IL18

GO:0051145

BP

smooth muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.

CTNNB1, ACVR1, MEF2C, NFATC4, GATA6, MKL2

GO:0051146

BP

striated muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.

SPAG9, KRAS, RB1, CDH2, IGFBP5, AKT1, MTPN, MAPK14

GO:0051147

BP

regulation of muscle cell differentiation

Any process that modulates the frequency, rate or extent of muscle cell differentiation.

CAMK1, SUPT6H, MEGF10

GO:0051148

BP

negative regulation of muscle cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation.

PTBP1

GO:0051149

BP

positive regulation of muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.

SPAG9, TCF3, CDH2, CTNNA2, CTNNA1, CTNNB1, CDH15, CDC42, MEF2A, MEF2C, CAMK1, MAPK14, RBM4

GO:0051150

BP

regulation of smooth muscle cell differentiation

Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation.

BMP4, FGFR2, ZEB1

GO:0051151

BP

negative regulation of smooth muscle cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation.

EREG, FOXO4, RBPMS2, PRDM6

GO:0051152

BP

positive regulation of smooth muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation.

TGFB1, SMARCD3

GO:0051153

BP

regulation of striated muscle cell differentiation

Any process that modulates the frequency, rate or extent of striated muscle cell differentiation.

HDAC9

GO:0051154

BP

negative regulation of striated muscle cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation.

YBX1, EZH2

GO:0051155

BP

positive regulation of striated muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.

NRG1, MORF4L2, HOPX

GO:0051156

BP

glucose 6-phosphate metabolic process

The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6.

GPI, G6PD, HK1, G6PC, HKDC1, G6PC3

GO:0051160

BP

L-xylitol catabolic process

The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group.

SORD

GO:0051164

BP

L-xylitol metabolic process

The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets.

SORD

GO:0051168

BP

nuclear export

The directed movement of substances out of the nucleus.

NEMF, HNRNPA1, ATXN1, NCBP1, AKAP13, RITA1, PHAX

GO:0051169

BP

nuclear transport

The directed movement of substances into, out of, or within the nucleus.

PSIP1, BANF1, HMGA1

GO:0051170

BP

nuclear import

The directed movement of substances into the nucleus.

HNRNPA1, SNRPB, GEMIN4, SNRPF, SNRPD1, SNRPD2, SNRPD3, GEMIN5, GEMIN6, HTATIP2, DDX20

GO:0051174

BP

regulation of phosphorus metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

FAM20C

GO:0051180

BP

vitamin transport

The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

APOA1, GC

GO:0051181

BP

cofactor transport

The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein.

PPT1

GO:0051186

BP

cofactor metabolic process

The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

PPT1

GO:0051205

BP

protein insertion into membrane

The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.

EGFR, REEP1

GO:0051208

BP

sequestering of calcium ion

The process of binding or confining calcium ions such that they are separated from other components of a biological system.

HSP90B1, CALR

GO:0051209

BP

release of sequestered calcium ion into cytosol

The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.

PTPRC, FGF2, DRD2, PLCG2, F2R, HTR2C, DDIT3, HTR2B, PKD2, ITPR2, ITPR3, ITPR1, RASA3, RYR3, CHERP, TRPV1, TPCN2, RYR2, ERO1A

GO:0051216

BP

cartilage development

The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

SMAD9, HOXA3, TIMP1, TYMS, EDN1, HOXC4, ESRRA, BMP3, COL11A2, CD44, BMP6, ITGB8, MAPK3, BMP8B, SOX6, CHI3L1, ZEB1, WNT5A, SOX9, LUM, EVC, GNAS, PKD1, COL10A1, ZBTB16, DLX2, HYAL2, SMAD1, HIF1A, GNAS, BMP8A, SULF2, SULF1, CSGALNACT1, SMAD5, BBS2, MKKS, GHRL

GO:0051220

BP

cytoplasmic sequestering of protein

The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell.

LATS1, FLNA, YWHAB

GO:0051222

BP

positive regulation of protein transport

Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

TNF, CHP1

GO:0051223

BP

regulation of protein transport

Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

DNAJA1, RAB11A

GO:0051224

BP

negative regulation of protein transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

WWP2, SNX3, NDFIP1, NDFIP2, SNX12

GO:0051225

BP

spindle assembly

The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.

HDAC3, NCOR1, HAUS5, TNKS, TUBB, RCC1, CSNK1D, NEK2, GOLGA2, CHD4, HAUS6, NEK7, HAUS1, HAUS7, TUBB1, HAUS4, NEK6, HAUS2, STARD9

GO:0051228

BP

mitotic spindle disassembly

The controlled breakdown of the spindle during a mitotic cell cycle.

SPAST

GO:0051232

BP

meiotic spindle elongation

The lengthening of the distance between poles of the spindle during a meiotic cell cycle.

PPP2R1A

GO:0051238

BP

sequestering of metal ion

The process of binding or confining metal ions such that they are separated from other components of a biological system.

S100A7

GO:0051246

BP

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

CUL4A

GO:0051247

BP

positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

KLF4, MAPK8, MTPN, MAP2K5, MAPK7, KLF2

GO:0051250

BP

negative regulation of lymphocyte activation

Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation.

TYRO3, MERTK

GO:0051252

BP

regulation of RNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.

RASA1, NOVA1

GO:0051256

BP

mitotic spindle midzone assembly

The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone.

KIF4A, KIF23, AURKB, RACGAP1, CDC14A

GO:0051257

BP

meiotic spindle midzone assembly

The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis.

MLH1

GO:0051258

BP

protein polymerization

The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein.

CHMP2A, FGA, FGB, FGG, VTN, MID1IP1

GO:0051259

BP

protein oligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

NOL3, BCL10, NPM1, AR, GJA1, PFKL, TNFAIP3, NME2, STX2, GJA5, TMED10, IRAK1, CAV2, BLM, TEK, BAX, AHNAK, TRIM28, CAMK2D, NBR1, QPRT, HGSNAT, DGKH, CHP1, GRHPR, NUFIP1, AMFR, SH3GLB1