GO:0048535

BP

lymph node development

The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes.

TGFB1, IL7R, FADD, RC3H2, CD248, TNFRSF11A

GO:0048536

BP

spleen development

The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.

BCL2L11, TCF21, BCL2, BCL3, FAS, PBX1, CDKN2B, PRKDC, ADAM17, CDH17, FADD, PKN1, RBM15, PITX2, CITED2, RC3H2

GO:0048538

BP

thymus development

The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.

HOXA3, TBX1, BCL2L11, CCNB2, RAF1, BCL2, TYR, RAG1, MAPK3, MAPK1, CTNNB1, TGFBR1, PBX1, CRKL, PSEN1, LMO4, PRKDC, MAP2K1, FADD, HES1, SLC46A2, MAFB, MAD1L1

GO:0048539

BP

bone marrow development

The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure.

LRP5, PTPRC, LRRC17, SBDS

GO:0048541

BP

Peyer's patch development

The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes.

ADA, STAT5B, ID2

GO:0048545

BP

response to steroid hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.

IDH1, CA2, SPP1, HMGB2, LOX, SRD5A2, TGFBR2, MDM2, PAQR8, PAQR5

GO:0048546

BP

digestive tract morphogenesis

The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.

EGFR, BCL2, HIF1A, BBS7, SFRP1

GO:0048549

BP

positive regulation of pinocytosis

Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.

ACTN4, PPT1, ANKFY1

GO:0048550

BP

negative regulation of pinocytosis

Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.

NR1H2, CAV1, NR1H3

GO:0048557

BP

embryonic digestive tract morphogenesis

The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.

TCF21, SHOX2, GLI3, PDGFRA, FGFR2, ID2, NIPBL, RBPMS2, PITX2

GO:0048560

BP

establishment of anatomical structure orientation

The process that determines the orientation of an anatomical structure with reference to an axis.

TTC8

GO:0048562

BP

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

RBP4, HOXC4, FGFR2

GO:0048563

BP

post-embryonic animal organ morphogenesis

Morphogenesis, during the post-embryonic phase, of an animal tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

BCL2L11

GO:0048565

BP

digestive tract development

The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.

COBL, TGFB1, COL3A1, CYP1A1, SLC4A2, RB1, KIT, CCNB1, ITGB4, FGFR2, ITGA6, OXTR, CCKBR, TGFBR2, PKD1, LGR4, CHD8, PDGFC, TRPS1

GO:0048566

BP

embryonic digestive tract development

The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.

ALDH1A2, ADA, TNF, SCT, GLI2, GLI3, CXCL8, FGF9, TGFB2, PCSK5, RARRES2

GO:0048568

BP

embryonic organ development

Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

MBD3, ERCC1, FGFR2, BMPR1A, RAD23B, POLE, PTCH1, RBBP6, WDR48, ZFPM2

GO:0048569

BP

post-embryonic animal organ development

Development, taking place during the post-embryonic phase of an animal tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

LDHA

GO:0048570

BP

notochord morphogenesis

The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.

KDM6A, WNT5A

GO:0048571

BP

long-day photoperiodism

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length.

AGRP

GO:0048589

BP

developmental growth

The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.

TYMS, GLI2, GLI3, ADM, BMPR1A, GAS1, SMAD3, GNAS, SMAD4, ALKBH1, GNAS, NIPBL, ASPM, PYGO2, CHST11, ZMIZ1

GO:0048592

BP

eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized.

COL5A2, COL5A1, NIPBL

GO:0048593

BP

camera-type eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.

MFN2, GDF11, GLI3, SKI, VEGFA, COL8A2, YY1, EPHB2, EPHB1, RING1, SHROOM2, IFT122, TENM3

GO:0048596

BP

embryonic camera-type eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized during embryonic development.

TH, ZEB1, SP3, HIPK2

GO:0048597

BP

post-embryonic camera-type eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized during post-embryonic development.

BAX

GO:0048598

BP

embryonic morphogenesis

The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.

FGF2, HTR2B, FLRT3

GO:0048599

BP

oocyte development

The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.

MEIOC, INHBB, BCL2, ZP3, CTNNB1

GO:0048608

BP

reproductive structure development

The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.

TCF21, FGFR2, DLG1

GO:0048609

BP

multicellular organismal reproductive process

The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.

COMT, PTPN11

GO:0048611

BP

embryonic ectodermal digestive tract development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure.

VPS52

GO:0048617

BP

embryonic foregut morphogenesis

The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase.

CTNNB1, GATA4, SMAD3, ACVR2B, SMAD2, SOX17

GO:0048619

BP

embryonic hindgut morphogenesis

The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase.

DACT1

GO:0048625

BP

myoblast fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.

EPAS1, TCF7L2

GO:0048627

BP

myoblast development

The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.

SOX15, SDC1

GO:0048632

BP

negative regulation of skeletal muscle tissue growth

Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth.

MSTN

GO:0048633

BP

positive regulation of skeletal muscle tissue growth

Any process that activates, maintains or increases the rate of skeletal muscle growth.

MTM1

GO:0048635

BP

negative regulation of muscle organ development

Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.

IL6

GO:0048638

BP

regulation of developmental growth

Any process that modulates the frequency, rate or extent of developmental growth.

AR, NIPBL

GO:0048639

BP

positive regulation of developmental growth

Any process that activates, maintains or increases the rate of developmental growth.

INSR, LEP, PRKDC, PLCB1

GO:0048641

BP

regulation of skeletal muscle tissue development

Any process that modulates the frequency, rate or extent of skeletal muscle tissue development.

MEGF10

GO:0048642

BP

negative regulation of skeletal muscle tissue development

Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.

USP2, DKK1, TGFB1, TWIST1, TSC22D3

GO:0048643

BP

positive regulation of skeletal muscle tissue development

Any process that activates, maintains or increases the rate of skeletal muscle tissue development.

USP2, FLOT1, HMGCR, CTNNB1, MEF2C, SOX17

GO:0048644

BP

muscle organ morphogenesis

The process in which the anatomical structures of muscle are generated and organized.

TBX1, LIF, TCF15, ARID5B

GO:0048645

BP

animal organ formation

The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ.

HOXA3, AR, GATA6

GO:0048646

BP

anatomical structure formation involved in morphogenesis

The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

GATA4, NKX2-1, DLX5, GRB2, TRPS1

GO:0048659

BP

smooth muscle cell proliferation

The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.

AGT

GO:0048660

BP

regulation of smooth muscle cell proliferation

Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.

XRCC5, CTNNB1, PRKDC, NR4A3, TCF7L2

GO:0048661

BP

positive regulation of smooth muscle cell proliferation

Any process that activates or increases the rate or extent of smooth muscle cell proliferation.

EREG, ABCC4, EGFR, PDGFB, TNF, HMGCR, IGF1, IL6, EDN1, JUN, THBS1, IL6R, HMOX1, PDGFRB, BMP4, CCL5, AKR1B1, ITGA2, S1PR1, FGFR2, TGM2, PTAFR, AKT1, PTGS2, TGFBR2, NAMPT, IRAK1, CDH13, HDAC4, ID2, SKP2, CAMK2D, IL18, NPY5R, RBPMS2, NR4A3, HBEGF, PDGFD, FOXP1, RETN, PPARGC1A

GO:0048662

BP

negative regulation of smooth muscle cell proliferation

Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.

KLF4, MFN2, ANG, APOD, HMOX1, NPR3, IGFBP3, OGN, TNFAIP3, COMT, IGFBP5, IL12A, PPARG, PPARD, ILK, ADIPOQ, TRIB1, PPARGC1A, NDRG4, NDRG2

GO:0048663

BP

neuron fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.

BMP4, TGFBR1, TGFB2, NRG1, ID2, SMAD4, ZNF521

GO:0048664

BP

neuron fate determination

The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed.

CDC42

GO:0048665

BP

neuron fate specification

The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.

ASCL1

GO:0048666

BP

neuron development

The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

HS6ST1, TDP2, GLI2, SKI, LIF, XBP1, PSEN1, PPT1, EPHA5, TGFB2, MEF2C, MTMR2, DPYSL3, CTF1, TENM4, THOC2, SECISBP2, WNK1, TENM3

GO:0048667

BP

cell morphogenesis involved in neuron differentiation

The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.

RB1, SLC1A3, ID2, MEF2C, HES1, UNK

GO:0048668

BP

collateral sprouting

The process in which outgrowths develop from the shafts of existing axons.

BDNF, EFNA5, HDAC6

GO:0048669

BP

collateral sprouting in absence of injury

The process in which outgrowths develop from the axons of intact undamaged neurons.

COBL, APP

GO:0048671

BP

negative regulation of collateral sprouting

Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting.

IFRD1, FGF13

GO:0048672

BP

positive regulation of collateral sprouting

Any process that activates or increases the frequency, rate or extent of collateral sprouting.

BDNF, EFNA5, IST1

GO:0048675

BP

axon extension

Long distance growth of a single axon process involved in cellular development.

DCLK1, SEMA7A, ULK1, ITGB1, MAPT, MAP1B, LHX2, CDK5, RAPH1, CYFIP1, SLC9A6

GO:0048678

BP

response to axon injury

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.

MATN2, CST3, NTRK1, APOD, CDK1, LYN, LGALS1, DRD2, ARF4, RANGAP1, BAX, DPYSL3, MTR, TXN2, FLRT3

GO:0048679

BP

regulation of axon regeneration

Any process that modulates the frequency, rate or extent of axon regeneration.

KLF4, PTPRF, MAP2K1, STK24

GO:0048680

BP

positive regulation of axon regeneration

Any process that activates, maintains or increases the rate of axon regeneration.

SCARF1, NDEL1

GO:0048681

BP

negative regulation of axon regeneration

Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.

EPHA4, PTEN

GO:0048685

BP

negative regulation of collateral sprouting of intact axon in response to injury

Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon.

SPP1

GO:0048692

BP

negative regulation of axon extension involved in regeneration

Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in regeneration.

TNR

GO:0048697

BP

positive regulation of collateral sprouting in absence of injury

Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury.

WNT3

GO:0048698

BP

negative regulation of collateral sprouting in absence of injury

Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting in the absence of injury.

SPG20

GO:0048699

BP

generation of neurons

The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.

MAPT, TGFB2, CDK6, THOC2

GO:0048701

BP

embryonic cranial skeleton morphogenesis

The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase.

TBX1, BMP4, PDGFRA, FGFR2, TGFBR1, TGFBR2, MMP14, MMP16, SMAD3, GNAS, DLX2, RUNX2, TWIST1, SMAD2, GNAS

GO:0048702

BP

embryonic neurocranium morphogenesis

The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain.

TULP3, MTHFD1, HOXA1, NDST1, MTHFD1L, MED12

GO:0048703

BP

embryonic viscerocranium morphogenesis

The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.

HOXA2, TBX1, MTHFD1, NDST1, MEF2C, NIPBL, MTHFD1L, RDH10, CHST11

GO:0048704

BP

embryonic skeletal system morphogenesis

The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.

HOXA3, MYCN, HOXB5, GLI3, COL11A1, PDGFRA, HOXD10, HOXA6, ZEB1, DLG1, MDFI

GO:0048705

BP

skeletal system morphogenesis

The process in which the anatomical structures of the skeleton are generated and organized.

PRKRA, ZFAND5, FGFR1, FGFR2, TGFBR1, PSEN1, TCF15, HYAL2, ACVR2B, ARID5B, ANKRD11, FAM101A, FAM101B, WDR48, HHIP, CSRNP1

GO:0048706

BP

embryonic skeletal system development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.

COL1A1, RBP4, ACVR2A, FGF9, PBX1, WNT5A, SP3, KIAA1217, SULF2, SULF1, PCSK5, SLC35D1, MKS1

GO:0048708

BP

astrocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.

S100B, SOX6, STAT3, NOTCH1, EIF2B5

GO:0048709

BP

oligodendrocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.

TSPAN2, VTN, ERBB2, CNP, GLI3, CSK, CDKN2C, NKX2-1, NOTCH1, SOX9, SOX8, CDK5, NRG1, SRSF1, NTRK2, BOK, MYRF, DUSP10

GO:0048710

BP

regulation of astrocyte differentiation

Any process that modulates the frequency, rate or extent of astrocyte differentiation.

EPHA4

GO:0048711

BP

positive regulation of astrocyte differentiation

Any process that activates or increases the frequency, rate or extent of astrocyte differentiation.

BIN1, SERPINE2, BMP2, LIF, MAG, IL6ST, NOTCH1, ID2, HES1, CLCF1, PRPF19

GO:0048712

BP

negative regulation of astrocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation.

DAB1, F2, MYCN, ID4

GO:0048713

BP

regulation of oligodendrocyte differentiation

Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation.

WDR1, TNFRSF21

GO:0048714

BP

positive regulation of oligodendrocyte differentiation

Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.

TLR2, PPARG, CXCR4, HDAC1, RHEB, TENM4, HDAC2

GO:0048715

BP

negative regulation of oligodendrocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.

CTNNB1, NOTCH1, ID4, ID2, DLX2, HES1, DUSP10

GO:0048730

BP

epidermis morphogenesis

The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.

KLF4, FGFR2

GO:0048732

BP

gland development

The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.

TCF21, CCKBR

GO:0048733

BP

sebaceous gland development

The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure.

CBX7, SMAD4

GO:0048738

BP

cardiac muscle tissue development

The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.

SIN3B, ALDH1A2, RBP4, NDUFV2, PLN, GJC1, PTEN, NPRL3, SGCD, SGCZ

GO:0048739

BP

cardiac muscle fiber development

The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure.

VEGFA, MYH11, CXADR, NEXN, TTN

GO:0048741

BP

skeletal muscle fiber development

The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.

GPX1, SKI, CAV2, PPP3CA, HOMER1, DNER, SEPN1, FAM65B

GO:0048742

BP

regulation of skeletal muscle fiber development

Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.

HDAC4, FBXO22, HDAC9

GO:0048743

BP

positive regulation of skeletal muscle fiber development

Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.

SHOX2, BCL2

GO:0048745

BP

smooth muscle tissue development

The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure.

FOXP2, ZFAND5, BMP4, DLG1

GO:0048747

BP

muscle fiber development

The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.

UCHL1, CHRNB1, DMD, FLNC, SGCB

GO:0048752

BP

semicircular canal morphogenesis

The process in which the anatomical structures of the semicircular canals are generated and organized.

TBX1, ZEB1, NR4A3, CHD7

GO:0048753

BP

pigment granule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule.

BCL2

GO:0048754

BP

branching morphogenesis of an epithelial tube

The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.

SLIT2, MYCN, MET, GLI2, BMP4, B4GALT1, VEGFA, NOTCH1, MMP14, PPP1CA, PKD1, MKS1, TIMELESS

GO:0048755

BP

branching morphogenesis of a nerve

The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).

DRD2, FGFR2, DLX2, RERE

GO:0048762

BP

mesenchymal cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.

FGFR1, BMP2, FGFR2, TGFBR1, HMGA2

GO:0048769

BP

sarcomerogenesis

The process in which sarcomeres are added in series within a fiber.

TTN

GO:0048771

BP

tissue remodeling

The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.

PLG, THBS4, LIPA, MMP14, CSPG4

GO:0048789

BP

cytoskeletal matrix organization at active zone

The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane.

NLGN1

GO:0048791

BP

calcium ion-regulated exocytosis of neurotransmitter

The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels.

SYT1, SYTL5, SYTL4, SYT11, RIMS4, RIMS2