GO:0046135

BP

pyrimidine nucleoside catabolic process

The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).

UPP2, TYMP, NT5E, DPYD, UPP1, NT5C

GO:0046166

BP

glyceraldehyde-3-phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis.

TKT, TPI1

GO:0046167

BP

glycerol-3-phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol.

GK

GO:0046177

BP

D-gluconate catabolic process

The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose.

IDNK

GO:0046185

BP

aldehyde catabolic process

The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O.

GPI

GO:0046204

BP

nor-spermidine metabolic process

The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane.

SAT1, SAT2

GO:0046208

BP

spermine catabolic process

The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging.

SAT1, SAT2

GO:0046209

BP

nitric oxide metabolic process

The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.

TLR2

GO:0046219

BP

indolalkylamine biosynthetic process

The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group.

TPH2

GO:0046226

BP

coumarin catabolic process

The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids.

CYP2A6

GO:0046320

BP

regulation of fatty acid oxidation

Any process that modulates the frequency, rate or extent of fatty acid oxidation.

FABP3, PDK4

GO:0046321

BP

positive regulation of fatty acid oxidation

Any process that activates or increases the frequency, rate or extent of fatty acid oxidation.

PPARG, PPARA, NR4A3, PPARGC1A

GO:0046322

BP

negative regulation of fatty acid oxidation

Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.

ACADVL, DGAT2

GO:0046323

BP

glucose import

The directed movement of the hexose monosaccharide glucose into a cell or organelle.

SLC2A10, SLC2A4, HNF1A, SESN2, RAB4B, SLC2A6

GO:0046324

BP

regulation of glucose import

Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.

ASPSCR1

GO:0046325

BP

negative regulation of glucose import

Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.

TNF, ENPP1, LEP, GRB10, PEA15, VIMP, LMBRD1

GO:0046326

BP

positive regulation of glucose import

Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.

CREBL2, FGF19, PTH, INS, IGF1, INSR, RHOQ, PIK3R1, AKT1, AKT2, IRS1, PRKCI, SLC1A2, ARPP19, RAP1A, ADIPOQ, MAPK14, ADIPOR2, ITLN1, SORBS1, CAPN10, IRS2

GO:0046327

BP

glycerol biosynthetic process from pyruvate

The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate.

PCK1

GO:0046328

BP

regulation of JNK cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.

MAP4K4, IGF1R, RAP2A, EPHB1, F2RL1, MAPK8IP2, ULK4, MAPK8IP3, MAPK8IP1

GO:0046329

BP

negative regulation of JNK cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.

HDAC3, PER1, PARK2, NCOR1, AMBP, AKT1, DUSP3, F2RL1, GPS2, ZMYND11, ZNF675, DUSP19, MARVELD3, ITCH, PINK1, TAOK3, DACT1

GO:0046330

BP

positive regulation of JNK cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.

TLR4, SDCBP, AXIN1, TLR3, RIPK2, FZD7, GADD45B, GADD45G, FGF19, IL1A, IL1B, HMGB1, GADD45A, CD27, CTGF, FLT4, LTBR, F2RL1, TIRAP, CDC42, RIPK1, TPD52L1, MINK1, RB1CC1, DUSP19, MAP3K5, TAOK3, HIPK2, TRPV4, PLCB1, DUSP22, TNFRSF19, TAOK2, PYCARD

GO:0046331

BP

lateral inhibition

Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells.

HES1

GO:0046338

BP

phosphatidylethanolamine catabolic process

The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.

PNPLA8

GO:0046339

BP

diacylglycerol metabolic process

The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.

DGKZ, PGS1, DGKK, GPAT4, DGAT2

GO:0046340

BP

diacylglycerol catabolic process

The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.

APOA2, LIPE

GO:0046356

BP

acetyl-CoA catabolic process

The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.

NUDT7

GO:0046360

BP

2-oxobutyrate biosynthetic process

The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2.

THNSL2

GO:0046368

BP

GDP-L-fucose metabolic process

The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate.

FUT8

GO:0046370

BP

fructose biosynthetic process

The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose.

AKR1B1, SORD

GO:0046386

BP

deoxyribose phosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose.

PGM2, DERA

GO:0046390

BP

ribose phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar.

G6PD

GO:0046395

BP

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

PON1

GO:0046398

BP

UDP-glucuronate metabolic process

The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate.

CSGALNACT1

GO:0046415

BP

urate metabolic process

The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals.

G6PC, LRRC16A, SLC16A9

GO:0046425

BP

regulation of JAK-STAT cascade

Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway.

PIGU

GO:0046426

BP

negative regulation of JAK-STAT cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity.

SOCS2, SOCS3, SOCS6, LEPROT, SOCS1, FLRT2, SOCS5, DAB1, DCN, BGN, NF2, CAV1, PODN, RTN4RL1, LRRTM4, ADIPOR1, LRRC19, FLRT3, FLRT1

GO:0046427

BP

positive regulation of JAK-STAT cascade

Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.

PRL, GH1, IL6, KIT, CCL5, AKR1B1, IL10, F2R, LEP, NOTCH1, HES1, CYP1B1, CRLF3, ADIPOR1

GO:0046434

BP

organophosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound.

PON1

GO:0046449

BP

creatinine metabolic process

The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine.

MME, GHR, STAT5A, STAT5B

GO:0046452

BP

dihydrofolate metabolic process

The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate.

DHFR

GO:0046456

BP

icosanoid biosynthetic process

The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids.

FADS1, PLA2G4A

GO:0046459

BP

short-chain fatty acid metabolic process

The chemical reactions and pathways involving fatty acids with a chain length of less than C6.

ACOT4

GO:0046464

BP

acylglycerol catabolic process

The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.

ABHD12, MGLL, ABHD6

GO:0046466

BP

membrane lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane.

CYP1B1

GO:0046469

BP

platelet activating factor metabolic process

The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli.

PLA2G7

GO:0046470

BP

phosphatidylcholine metabolic process

The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.

PON1, GPLD1, APOA5

GO:0046473

BP

phosphatidic acid metabolic process

The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.

PLA2G2A

GO:0046474

BP

glycerophospholipid biosynthetic process

The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.

AJUBA

GO:0046475

BP

glycerophospholipid catabolic process

The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.

ABHD12, SMPD4, GDE1, PLA2G4C

GO:0046483

BP

heterocycle metabolic process

The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).

CYP2E1, CYP3A4, CYP2D6

GO:0046486

BP

glycerolipid metabolic process

The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.

DGKZ

GO:0046487

BP

glyoxylate metabolic process

The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.

NDUFAB1, PDHA1, DLD, DLAT, PDHB, DBT, BCKDHA, AGXT, BCKDHB, GCSH, DLST, OGDH, GRHPR, LIPT1

GO:0046488

BP

phosphatidylinositol metabolic process

The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.

SYNJ1, CSF1R, PDGFRB, DRD2, PLCB1

GO:0046490

BP

isopentenyl diphosphate metabolic process

The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids.

IDI2

GO:0046491

BP

L-methylmalonyl-CoA metabolic process

The chemical reactions and pathways involving L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals.

MCEE

GO:0046496

BP

nicotinamide nucleotide metabolic process

The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide.

CARKD

GO:0046498

BP

S-adenosylhomocysteine metabolic process

The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine.

DNMT3B, PEMT

GO:0046499

BP

S-adenosylmethioninamine metabolic process

The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt.

DNMT3B

GO:0046500

BP

S-adenosylmethionine metabolic process

The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.

AMD1, MTHFR, PEMT

GO:0046511

BP

sphinganine biosynthetic process

The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol.

SPTLC2

GO:0046512

BP

sphingosine biosynthetic process

The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.

SPTLC2, SPHK1

GO:0046513

BP

ceramide biosynthetic process

The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.

SPTLC2, CERS6, SGMS1, CERS5, SGMS2, CERS4, SMPD4

GO:0046521

BP

sphingoid catabolic process

The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.

SPHK1

GO:0046533

BP

negative regulation of photoreceptor cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.

NOTCH1, SOX9, SOX8

GO:0046541

BP

saliva secretion

The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin.

CHRM3

GO:0046543

BP

development of secondary female sexual characteristics

The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion.

STAT5B

GO:0046544

BP

development of secondary male sexual characteristics

The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.

STAT5B

GO:0046545

BP

development of primary female sexual characteristics

The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion.

ACVR1B, ADCYAP1R1, DACH1

GO:0046548

BP

retinal rod cell development

Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light.

NAGLU, NTRK2

GO:0046578

BP

regulation of Ras protein signal transduction

Any process that modulates the frequency, rate or extent of Ras protein signal transduction.

NUP62, FOXM1, SQSTM1

GO:0046579

BP

positive regulation of Ras protein signal transduction

Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.

NGF, NTRK1, IGF1, KITLG, NRG1, NOTCH2

GO:0046580

BP

negative regulation of Ras protein signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.

RASA4, SPRY2, SPRY1, MFN2, STAMBP, FBP1, TIMP2, RASA1, NUP62, TGFB2, PPP2CB, RAPGEF1, RASA3, RASA2, SYNGAP1, MAPKAP1, RABGEF1

GO:0046587

BP

positive regulation of calcium-dependent cell-cell adhesion

Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion.

KIFAP3

GO:0046596

BP

regulation of viral entry into host cell

Any process that modulates the frequency, rate or extent of the viral entry into the host cell.

TRIM25, TRIM62

GO:0046597

BP

negative regulation of viral entry into host cell

Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell.

SNX3, APCS, IFITM1, PTX3, IFITM3, TRIM26, TRIM25, TRIM8

GO:0046598

BP

positive regulation of viral entry into host cell

Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell.

TRIM38, P4HB, LGALS1

GO:0046599

BP

regulation of centriole replication

Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole.

NPM1, STIL, CENPJ, PLK2

GO:0046600

BP

negative regulation of centriole replication

Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication.

TRIM37, BRCA1, MDM1

GO:0046601

BP

positive regulation of centriole replication

Any process that activates or increases the frequency, rate or extent of centriole replication.

PLK4

GO:0046602

BP

regulation of mitotic centrosome separation

Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis.

CHEK1, NEK2, KIF11

GO:0046604

BP

positive regulation of mitotic centrosome separation

Any process that activates or increases the frequency, rate or extent of centrosome separation.

RANBP1

GO:0046605

BP

regulation of centrosome cycle

Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation.

AURKA

GO:0046618

BP

drug export

The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle.

SLC22A18, SLC47A1

GO:0046619

BP

optic placode formation involved in camera-type eye formation

Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles.

FRS2, PROX1

GO:0046620

BP

regulation of organ growth

Any process that modulates the frequency, rate or extent of growth of an organ of an organism.

BCL2L11, LATS1, FOXC1, LATS2

GO:0046621

BP

negative regulation of organ growth

Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.

PTEN, PTK2, STK4, FXN, WWC2, WWC1, WWC3

GO:0046622

BP

positive regulation of organ growth

Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.

SASH3, YAP1

GO:0046626

BP

regulation of insulin receptor signaling pathway

Any process that modulates the frequency, rate or extent of insulin receptor signaling.

OGT, TSC2, SIK2, NUCKS1, BAIAP2L1

GO:0046627

BP

negative regulation of insulin receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.

SOCS2, SOCS3, MSTN, SOCS1, IL1B, AHSG, PRKCB, PTPN2, ENPP1, IRS1, TSC2, RELA, PRKCQ, PRKCD, GRB10, KANK1, PID1, INPP5K, LMBRD1

GO:0046628

BP

positive regulation of insulin receptor signaling pathway

Any process that increases the frequency, rate or extent of insulin receptor signaling.

INS, IGF2, IRS1, LEP, SERPINA12, ADIPOR1, NR1H4, OSBPL8, NUCKS1

GO:0046629

BP

gamma-delta T cell activation

The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

CXADR, MICB, MICA

GO:0046631

BP

alpha-beta T cell activation

The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

INS

GO:0046632

BP

alpha-beta T cell differentiation

The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex.

ANXA1, RPL22

GO:0046633

BP

alpha-beta T cell proliferation

The expansion of an alpha-beta T cell population by cell division.

DOCK2

GO:0046636

BP

negative regulation of alpha-beta T cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.

LILRB1

GO:0046638

BP

positive regulation of alpha-beta T cell differentiation

Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.

PNP, ADA, GLI3, SYK, NKAP

GO:0046639

BP

negative regulation of alpha-beta T cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation.

GLI3

GO:0046641

BP

positive regulation of alpha-beta T cell proliferation

Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.

RIPK2, CD28, TNFSF4, SYK

GO:0046651

BP

lymphocyte proliferation

The expansion of a lymphocyte population by cell division.

HELLS

GO:0046653

BP

tetrahydrofolate metabolic process

The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

DHFR, MTHFD2, SHMT1, MTHFS, MTHFD1L, PIPOX