GO:0046654

BP

tetrahydrofolate biosynthetic process

The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

DHFR, GART

GO:0046655

BP

folic acid metabolic process

The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.

ALDH1L1, DHFR, MTHFD1, MTHFD2, FOLR1, SHMT1, SLC19A1, MTHFR, MTHFS, ALDH1L2, MTHFD1L, SLC46A1, MTHFD2L

GO:0046657

BP

folic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid.

MTHFS

GO:0046661

BP

male sex differentiation

The establishment of the sex of a male organism by physical differentiation.

FKBP4

GO:0046666

BP

retinal cell programmed cell death

Programmed cell death that occurs in the developing retina.

BAX

GO:0046671

BP

negative regulation of retinal cell programmed cell death

Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina.

BCL2

GO:0046676

BP

negative regulation of insulin secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.

PARK2, PDE8B, INHBB, DRD2, PFKL, IRS1, SREBF1, PTPN11, PPP3CA, HDAC1, KCNJ11, HADH, MIDN, BMP8A, SFRP1, GHSR, SYTL4, GHRL, STXBP5L

GO:0046677

BP

response to antibiotic

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

JAK2, TP53, CYP1A1, ALPL, IL6, HSP90AA1, CCL2, ADRB3, JAK1, ID1, SLC1A3, UQCRFS1, CASP9, PPP2CB, MDM2, HYAL2, CASP8, AOC3, RSRC1

GO:0046680

BP

response to DDT

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals.

CCNB1

GO:0046683

BP

response to organophosphorus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors.

TYMS, RFC3, AKR1C1

GO:0046684

BP

response to pyrethroid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage.

TH

GO:0046685

BP

response to arsenic-containing substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.

TNFRSF11B, CYP1A1, ALAD, CPOX, SERPINF1, CDKN1A, GCLC, PTEN, RBM4

GO:0046686

BP

response to cadmium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.

NPC1, CYB5A, PTH, PRNP, CDK1, GPI, SPARC, PCNA, ALAD, DTYMK, NUDT1, MAPK9, CDKN1B, GCLC, B2M, SORD, MTF1

GO:0046688

BP

response to copper ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.

IL1A, ICAM1, CDK1, SOD3, PAM, ATP5D, SORD, S100A13, LOXL2

GO:0046689

BP

response to mercury ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.

AQP9, ALAD, BSG

GO:0046690

BP

response to tellurium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus.

HMGCS1

GO:0046697

BP

decidualization

The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.

CYP27B1, STC2, CTSB, SPP1, VDR, LIF, JUNB, EPOR, PTGS2, BSG, STC1, PPARD, PTGIS, GHSR, GHRL

GO:0046709

BP

IDP catabolic process

The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate.

NUDT16, NUDT9

GO:0046710

BP

GDP metabolic process

The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate.

CASK, DLG4, MPP1, DLG1, TJP2

GO:0046711

BP

GDP biosynthetic process

The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate.

GUK1

GO:0046716

BP

muscle cell cellular homeostasis

The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.

MSTN, LARGE, ALDOA, IL6, GAA, DMD, LAMP2, CAPN3, MTM1, HIF1A, SGCZ

GO:0046717

BP

acid secretion

The controlled release of acid by a cell or a tissue.

DRD2

GO:0046718

BP

viral entry into host cell

The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.

WWP2, KPNA3, NPC1, SIVA1, CLDN1, LDLR, GYPA, TFRC, ITGB3, ICAM1, ITGB1, ITGAV, CTSB, CD55, ITGA5, RPSA, HSPA1A, HSPA1B, LAMP1, NCAM1, IDE, PVR, CD46, ITGA2, CR1, ITGB5, MRC1, DPP4, SERPINB3, EPS15, NUP153, EFNB2, CD81, DYNLT1, CXADR, TYRO3, SLC20A2, HYAL2, DAG1, SELPLG, GAS6, NECTIN1, SLC1A5, SCARB1, ITCH, WWP1, CD209, ZNF639, F11R

GO:0046724

BP

oxalic acid secretion

The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue.

AGXT

GO:0046726

BP

positive regulation by virus of viral protein levels in host cell

Any process where the infecting virus increases the levels of viral proteins in a cell.

STAU1, HACD3

GO:0046732

BP

active induction of host immune response by virus

The intentional, virally-encoded stimulation of a host defense response to viral infection.

TGFB1

GO:0046745

BP

viral capsid secondary envelopment

The process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope.

IST1

GO:0046755

BP

viral budding

A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space.

CHMP4B, VTA1

GO:0046777

BP

protein autophosphorylation

The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

AURKA, MUSK, MAP3K13, DAPK3, JAK2, ULK1, ERN1, STK17B, EGFR, ERBB2, NTRK1, EIF2S1, INSR, CSF1R, LYN, IGF1R, PDGFRB, FGR, KIT, BCR, FGFR1, PDGFRA, PRKACA, MAK, FGFR2, NME2, CAD, AKT1, GRK5, FLT4, ACVR1B, MAPKAPK2, CLK2, GSK3B, IRAK1, PRKX, NEK2, DAPK1, EPHB4, EPHB1, EPHA4, SIK1, CDK5, TEK, PTK2, TYRO3, DDR1, STK4, PAK2, TRIM28, RIPK1, CAMK2D, MELK, PRKD1, ERBB4, STK11, NTRK2, AAK1, MLK4, MINK1, UHMK1, AURKB, SMG1, TRPM7, PASK, VRK1, MKNK1, WNK3, PRKD2, SIK2, TAOK3, WNK1, CLK4, MKNK2, NEK6, ATP13A2, CDK12, EIF2AK4, NLK, TNIK, IRAK3, STK24

GO:0046778

BP

modification by virus of host mRNA processing

Any viral process that interferes with the processing of mRNA in the host cell.

PABPN1

GO:0046784

BP

viral mRNA export from host cell nucleus

The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation.

THOC7, ALYREF, THOC2, THOC3

GO:0046785

BP

microtubule polymerization

The addition of tubulin heterodimers to one or both ends of a microtubule.

ZNF207, TPPP, FGF13, TRPV4, CENPJ, FBXO5, HDGFRP3

GO:0046813

BP

receptor-mediated virion attachment to host cell

The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface.

ICAM1, CD81, GAS6

GO:0046822

BP

regulation of nucleocytoplasmic transport

Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.

PPP1R12A, PPP1CC, RBM4

GO:0046825

BP

regulation of protein export from nucleus

Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm.

XPO1, IFI27, PTPN11, UHMK1

GO:0046826

BP

negative regulation of protein export from nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.

TXN, SP100, RANGAP1, CDK5, SOX4, BARD1

GO:0046827

BP

positive regulation of protein export from nucleus

Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.

IL1B, TP53, TPR, PRKACA, SFN, GSK3B, EMD, MDM2, CAMK1, GAS6, ANP32B, XPO4, TCF7L2, GTSE1

GO:0046831

BP

regulation of RNA export from nucleus

Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm.

KHDRBS1

GO:0046832

BP

negative regulation of RNA export from nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm.

TPR, NUP153

GO:0046833

BP

positive regulation of RNA export from nucleus

Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm.

KHDRBS1

GO:0046834

BP

lipid phosphorylation

The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.

DGKZ, SPHK1

GO:0046835

BP

carbohydrate phosphorylation

The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.

PFKFB2, PFKFB1, HK1, GALK2, PFKFB3, PFKFB4, HKDC1, TKFC, GNPTAB, GNPTG, GNE

GO:0046836

BP

glycolipid transport

The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

NPC2, GLTP

GO:0046838

BP

phosphorylated carbohydrate dephosphorylation

The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it.

G6PC

GO:0046839

BP

phospholipid dephosphorylation

The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.

PLPP1, PLPP3, PLPPR4, PLPP5, PLPPR2

GO:0046847

BP

filopodium assembly

The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

EZR, ITGA6, CDC42, FGD6, FGD2, FGD4, SPATA13, TTYH1, ARHGEF4

GO:0046849

BP

bone remodeling

The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.

LRP5, IL6, NOTCH2, SPP2, LGR4

GO:0046850

BP

regulation of bone remodeling

Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.

LRP5, GJA1, LEP, LEPR

GO:0046851

BP

negative regulation of bone remodeling

Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling.

GREM1, SFRP1

GO:0046854

BP

phosphatidylinositol phosphorylation

The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.

PIK3CD, PIK3C2A, EREG, PIP5K1B, PIP5K1C, FGF18, FGF19, EGFR, PDGFB, PDGFA, ERBB2, FYN, FGF2, PDGFRB, KIT, CD28, FGFR1, VAV1, PDGFRA, KITLG, FGF7, FGFR2, ERBB3, PIK3R1, IMPA1, FGF9, BTC, IRS1, PIK3CA, PIK3CB, PIK3CG, INPP1, GRB2, PIP4K2B, NRG1, PTPN11, GAB1, ERBB4, TMEM150A, TTC7B, PIK3C3, FRS2, SMG1, HBEGF, PI4KB, KL, IP6K2, PIKFYVE, IRS2

GO:0046855

BP

inositol phosphate dephosphorylation

The process of removing a phosphate group from any mono- or polyphosphorylated inositol.

SYNJ1, IMPA1, INPP1, PTEN, MTMR2, INPP5A, INPP5K, INPP5E

GO:0046856

BP

phosphatidylinositol dephosphorylation

The process of removing one or more phosphate groups from a phosphatidylinositol.

SYNJ2, SYNJ1, PTEN, OCRL, MTM1, MTMR1, MTMR2, INPP5A, INPP5D, INPP5K, INPP5E

GO:0046879

BP

hormone secretion

The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.

ADM

GO:0046880

BP

regulation of follicle-stimulating hormone secretion

Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone.

INHBA

GO:0046881

BP

positive regulation of follicle-stimulating hormone secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone.

INHA, INHBA, INHBB, LEP, FOXL2, SMAD4

GO:0046882

BP

negative regulation of follicle-stimulating hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone.

INHA, INHBA, INHBB

GO:0046883

BP

regulation of hormone secretion

Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.

ANXA1, SCG5

GO:0046885

BP

regulation of hormone biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.

STC2

GO:0046886

BP

positive regulation of hormone biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.

KDM1A, EGR1, ARNT, HIF1A

GO:0046887

BP

positive regulation of hormone secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.

EDN1, NMB, CREB1, NMU, PTPN11

GO:0046888

BP

negative regulation of hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.

IL6, EDN1, NMB, LIF, IL11, ADORA1, ADIPOQ

GO:0046889

BP

positive regulation of lipid biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

CREBL2, INS, APOE, CREB1, AKT1, CCDC3, ABHD6, SORBS1

GO:0046890

BP

regulation of lipid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

MID1IP1

GO:0046900

BP

tetrahydrofolylpolyglutamate metabolic process

The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues.

GGH

GO:0046902

BP

regulation of mitochondrial membrane permeability

Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.

TP53, CNP, BCL2, PPIF, STAT3, BNIP3, PMAIP1, BAD

GO:0046903

BP

secretion

The controlled release of a substance by a cell or a tissue.

CA2, PRKCI, NPY2R, TPD52

GO:0046907

BP

intracellular transport

The directed movement of substances within a cell.

CSPG5, APOE, AFTPH, BBS7, APPBP2, SDCBP2, MKKS, FMN2

GO:0046928

BP

regulation of neurotransmitter secretion

Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.

SYN1, MEF2C, FMR1, SNCAIP

GO:0046929

BP

negative regulation of neurotransmitter secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.

PNKD, SYT11, SLC30A1

GO:0046931

BP

pore complex assembly

The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases.

CCT3, CCT8, ANO6, BAD

GO:0046939

BP

nucleotide phosphorylation

The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside.

DTYMK, GUK1, RAD50

GO:0046940

BP

nucleoside monophosphate phosphorylation

The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside.

DTYMK, AK4, CMPK1

GO:0046942

BP

carboxylic acid transport

The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

AQP9

GO:0046947

BP

hydroxylysine biosynthetic process

The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid.

PLOD1

GO:0046950

BP

cellular ketone body metabolic process

The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.

OXCT1

GO:0046951

BP

ketone body biosynthetic process

The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.

HMGCL, AACS, BDH2

GO:0046952

BP

ketone body catabolic process

The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.

OXCT1

GO:0046958

BP

nonassociative learning

A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment.

MAPK8IP2

GO:0046968

BP

peptide antigen transport

The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.

CD209

GO:0046985

BP

positive regulation of hemoglobin biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.

KLF4, PRMT1

GO:0047484

BP

regulation of response to osmotic stress

Any process that modulates the rate or extent of the response to osmotic stress.

TRPV4

GO:0047496

BP

vesicle transport along microtubule

The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.

DYNC1I1, HTT, VAMP7, RAB1A, CLN3, NDEL1, NDE1

GO:0047497

BP

mitochondrion transport along microtubule

The directed movement of a mitochondrion along a microtubule, mediated by motor proteins.

KIF1B, MAPT, LRPPRC, MAP1B, UXT

GO:0048002

BP

antigen processing and presentation of peptide antigen

The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.

CTSS, SLC11A1

GO:0048006

BP

antigen processing and presentation, endogenous lipid antigen via MHC class Ib

The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.

CD1D

GO:0048007

BP

antigen processing and presentation, exogenous lipid antigen via MHC class Ib

The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.

AP3D1, CD1D

GO:0048008

BP

platelet-derived growth factor receptor signaling pathway

The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.

PIK3C2A, NRP1, JAK2, ZFAND5, PLAT, PDGFB, PDGFA, PDGFRB, BCR, PDGFRA, IQGAP1, PTEN, PTPN11, PTPRJ, MYO1E, GAB1, RAPGEF1, ARID5B, CSRNP1, PDGFD, TXNIP, PDGFC

GO:0048009

BP

insulin-like growth factor receptor signaling pathway

The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.

IGF1, IGF1R, GHR, IGF2R, PIK3R1, AKT1, IRS1, TSC2, GRB10, GIGYF2, PLCB1, CRIM1

GO:0048010

BP

vascular endothelial growth factor receptor signaling pathway

Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.

NRP1, MAPK13, NRP2, ROCK2, HSPB1, CYBB, ITGB3, FYN, ITGAV, HSP90AA1, CCL2, VAV1, VEGFA, NCF2, PIK3R1, FLT4, PIK3CA, PIK3CB, MAPKAPK2, PGF, VEGFB, VEGFC, ACTB, CDC42, RHOA, RAC1, ACTG1, SHC2, PTK2, FOXC1, PAK2, BMPR2, NCF4, PRKD1, SHB, MAPK14, CYFIP1, SULF1, ABI1, ELMO1, CYFIP2, PRKD2, VAV3, WASF2

GO:0048011

BP

neurotrophin TRK receptor signaling pathway

A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.

NGF, RAF1, NTRK1, NGFR, PTPN11, SOS1, DDIT4

GO:0048012

BP

hepatocyte growth factor receptor signaling pathway

The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands.

NRP1, MET, HGF, MST1, SIRT2, MUC20

GO:0048013

BP

ephrin receptor signaling pathway

The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.

WASL, SDCBP, ADAM10, ARPC2, ARPC3, ROCK2, PAK3, AP2A2, NTRK1, FYN, LYN, MMP2, MMP9, CHN1, MYL12A, EFNA1, RASA1, EPHA3, EPHB2, SDC2, PSEN2, EFNA4, EFNB2, EFNA5, AP2S1, EPHA5, EPHB4, EPHB1, EPHA4, ARPC4, ACTB, CDC42, ACTR3, ACTR2, RHOA, RAC1, AP2B1, ACTG1, PTK2, PTPN11, TIAM1, ARHGEF7, ITSN1, ARHGEF28, APH1B, ANKS1A, APH1A, AP2M1, EPHA6, VAV3, GIT1

GO:0048014

BP

Tie signaling pathway

The series of molecular signals generated as a consequence of a Tie protein (a receptor) binding to one of its physiological ligands (an angiopoietin).

ANGPT2, TEK, ANGPT1

GO:0048015

BP

phosphatidylinositol-mediated signaling

A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

PIK3CD, PIK3C2A, EREG, OGT, FGF18, FGF19, EGFR, PDGFB, NGF, PDGFA, ERBB2, NTRK1, IGF1, FYN, CSF1R, IGF1R, FGF2, PDGFRB, KIT, CD28, FGFR1, EZR, VAV1, PDGFRA, NPR3, KITLG, ZP3, FGF7, FGFR2, ERBB3, PTAFR, PIK3R1, FGF9, AKT1, BTC, CA8, IRS1, PIK3CA, PIK3CB, PTEN, RHOA, NCS1, GRB2, MUC5AC, NRG1, PTPN11, GAB1, ERBB4, RICTOR, TNRC6A, PIK3C3, FRS2, HBEGF, MAPKAP1, MLST8, TNRC6C, AGO4, EXOC1, PI4KB, KL, AGO2, TNRC6B, IRS2

GO:0048016

BP

inositol phosphate-mediated signaling

Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6).

EDN1, EDN2, HRH1, ITPR2, ITPR3, INPP5A, ITPR1

GO:0048017

BP

inositol lipid-mediated signaling

A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids.

PLD1

GO:0048022

BP

negative regulation of melanin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.

WNT5A

GO:0048023

BP

positive regulation of melanin biosynthetic process

Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin.

ZEB2

GO:0048024

BP

regulation of mRNA splicing, via spliceosome

Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism.

SRSF10, SON, TIA1, SRPK2, JMJD6, YTHDC1, SRPK1, CWC22

GO:0048025

BP

negative regulation of mRNA splicing, via spliceosome

Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.

SAP18, SRSF10, HNRNPA2B1, PTBP1, RBMX, TRA2B, C1QBP, SRSF9, SRSF6, RNPS1