GO:0045838

BP

positive regulation of membrane potential

Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

GLRX, ANK3

GO:0045839

BP

negative regulation of mitotic nuclear division

Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.

CHEK1, NME6, BMP4, AURKAIP1

GO:0045840

BP

positive regulation of mitotic nuclear division

Any process that activates or increases the frequency, rate or extent of mitosis.

EREG, AURKA, LRP5, PDGFB, TGFA, INS, IGF2, IL1A, IL1B, IGF1, EDN1, INSR, PDGFRB, CD28, BTC, PHIP, NUSAP1, RGCC, SH2B1

GO:0045842

BP

positive regulation of mitotic metaphase/anaphase transition

Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.

RB1, CUL3, ESPL1, DLGAP5

GO:0045843

BP

negative regulation of striated muscle tissue development

Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development.

SOX15, BMP4, SIRT2, LUC7L

GO:0045844

BP

positive regulation of striated muscle tissue development

Any process that activates or increases the frequency, rate or extent of striated muscle development.

GJA1, MKL2

GO:0045859

BP

regulation of protein kinase activity

Any process that modulates the frequency, rate or extent of protein kinase activity.

IKBKAP, FGR, CDK4, RAC2, CDC42, TRPT1, SMG8, TTN, GCN1, ELP4, TSPYL2, ECT2, ELP3, KIDINS220, FAF1

GO:0045860

BP

positive regulation of protein kinase activity

Any process that activates or increases the frequency, rate or extent of protein kinase activity.

CYR61, EREG, DAB1, GCG, TNF, CD4, RPLP1, PTPRC, ZP3, CDC25B, SDC4, CDKN1A, IQGAP1, PRKAG1, RAP1A, VLDLR, CDK5, CENPE, PTK2, GAS6, MMD, CACUL1, DUSP19, ALS2, SNX9

GO:0045861

BP

negative regulation of proteolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

F2, PLAT, CST3, CSTA, KNG1, INS, CSTB, SERPINE2, IDE, SERPINB3, AKT1, NR1H2, CDK5, CLN3, DNAJC1, HDAC6

GO:0045862

BP

positive regulation of proteolysis

Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

OGT, CAPN3, PLK1, IST1, ASPH, FADD, CASP8, HDAC2, BAD, CYFIP2, PERP, AURKAIP1, CLN6, BTRC

GO:0045869

BP

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.

HMGA2, TRIM28, INPP5K, APOBEC3G

GO:0045870

BP

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

Any process that activates or increases the frequency, rate or extent of retroviral genome replication.

TOP2A

GO:0045875

BP

negative regulation of sister chromatid cohesion

Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion.

ESPL1, WAPL

GO:0045876

BP

positive regulation of sister chromatid cohesion

Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion.

SFPQ

GO:0045879

BP

negative regulation of smoothened signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.

TULP3, RB1, SERPINE2, GLI3, PTCH1, RUNX2, KCTD11, HHIP, SALL3, IFT122, SUFU, BTRC

GO:0045880

BP

positive regulation of smoothened signaling pathway

Any process that activates or increases the frequency, rate or extent of smoothened signaling.

SHOX2, FGF9, CTNNA1, EVC, CHSY1, SFRP1, DCDC2, INTU

GO:0045892

BP

negative regulation of transcription, DNA-templated

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

WWP2, ARNTL, FOXN3, BHLHE40, EREG, BTAF1, HDAC3, BIRC5, FOXP2, PER1, RBFOX2, CBFA2T2, KLF4, ATP8B1, KDM1A, GREM1, RAMP3, DNAJB6, ZNF253, ZNF217, PEX14, GMNN, RPS6KA5, HEXIM1, ZBTB7A, PDGFB, TGFB1, TNF, TP53, JUN, RB1, ENO1, GLI3, THRA, IRF1, VDR, BMP2, BMP4, XRCC5, POU2F1, FABP4, GCFC2, ZNF12, ZNF24, HMGA1, CEBPB, WT1, NR1D1, BCL3, CAPN3, ZP3, SFPQ, TNFSF4, NR2F2, MT3, HMGB2, CALR, YWHAB, CTNNB1, PHB, DDIT3, ZNF93, AHR, PPARG, ZEB1, BRCA1, ID1, BCL6, WNT5A, ELK3, NKX2-1, CBX5, CDKN1B, NOTCH1, ID4, LIMS1, SOX9, GCLC, CENPF, PPM1F, CEBPD, CDKN1C, ASCL1, DAP, SMARCA2, SMARCA4, NR0B1, HMGA2, ATXN1, NR1H2, FOXG1, HDAC4, CTBP2, SOX8, FOXL2, UBE2I, ELF3, CBX1, FOXK1, ZBED6, DAB2, CDK5, PURA, MDM2, E2F1, SET, NRG1, ID2, SP3, ID3, HHEX, CREM, PPARD, RELA, TLE1, ZNF91, ZBTB16, RING1, KHDRBS1, FOXM1, AES, FOXO1, ILF3, STRN3, KLF10, CBX3, TRIM28, IKZF1, SMAD4, HDAC1, C1D, RUNX2, GAS6, HES1, ARID5B, NR1D2, NONO, PTPRK, TWIST1, SMAD2, CCDC85B, ADIPOQ, EZH2, CRY1, IFI16, ZNF423, LRRFIP1, GON4L, PDCD4, DEPDC1, ZNF658, NIPBL, ZNF280D, ATF7IP, KCTD1, BEND5, ZBTB33, ZNF280B, PPARGC1B, GATAD2A, TMPRSS6, MINA, NOSTRIN, SIRT2, YAF2, CCAR2, SFRP1, NKAP, EID2, ZBTB38, SMARCC2, ZFPM2, PSPC1, KAT6B, HDAC2, PROX1, KAT6A, GATA6, PBXIP1, HIC2, PRMT6, PRICKLE1, PHF12, TRIB3, ATOH8, RSF1, SPEN, SETDB2, PFDN5, MPHOSPH8, PHB2, MDFI, CITED1, CITED2, MYBBP1A, INPP5K, LGR4, FOXP3, TRIM6, ZNF350, WWP1, EPC1, IKZF4, FOXP1, SUV39H2, ZNF552, SUDS3, SMURF2, PATZ1, CHD8, BRD7, PLCB1, HEYL, TCF7L2, KMT5A, PRDM6, RLIM, BCLAF1, RBAK, ZNF224, NDUFA13, ZBTB4, HDAC6, DKK3, KDM5B, LIMD1, MLX, DACH1, ZNF639, HDAC9, ZHX1, YEATS2, SNX6, TIMELESS, TRIM33, PA2G4, HDAC5, ZNF148, RASD1, BTRC, TSC22D4, L3MBTL1, LOXL2, HES2, HEY1, ZNF706, EID1

GO:0045893

BP

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

APBB1, ARNTL, FOXN3, NR5A2, ARID1A, MSTN, IRF6, AXIN1, TOX3, TGFB1I1, TBX1, KLF4, FOXO3, MED14, SMARCA5, CREBL2, EDF1, TBL1X, MITF, FZD7, LRP5, SUPT3H, TADA3, LRP6, KLF7, SEC14L2, BMP10, YEATS4, NFATC1, BMP15, BCL10, AGT, FOS, MYC, PDGFB, TGFB1, TNF, IL1B, COL1A1, ESR1, MYCN, TP53, IGF1, IL6, JUN, INSR, RB1, NPM1, INHBA, FGF2, GLI2, GLI3, MYBL1, AR, IRF1, EGR2, BMP2, BMP4, ETS1, ETS2, TCF4, TCF3, CREB1, HMGA1, IFNAR1, TAL1, ERCC2, EGR1, ATF4, ELK1, WT1, NFKB1, CCNA2, NR1D1, BCL3, CAPN3, HNF1A, MDK, ZP3, FGF7, IL10, SP100, NR2F2, CDK2, F2R, NFYB, MT3, HMGB2, ARNT, SMARCA1, MAPK1, KDM5A, OTX2, FOXN2, CKS2, CTNNB1, PHB, RORA, DDIT3, AHR, MAP2K2, TGFBR1, NUP62, PPARG, BRCA1, STAT3, WNT5A, GATA4, NKX2-1, NOTCH1, SOX9, NRIP1, PSEN1, CDKN1C, AGTR2, LHX2, CDK7, SMARCA2, SMARCA4, BRCA2, IRAK1, NEK4, MRPL12, HMGA2, BLM, NR1H2, DLX5, HDAC4, SOX8, FOXL2, CKS1B, ELF3, SMAD3, FOXK1, DAB2, TFAM, NDP, E2F1, RUNX1, ID2, SP3, MAP2K1, CREB5, POU3F1, PPARD, RELA, ACVR1, YWHAH, ZBTB16, MEF2C, PAX8, SOX4, PPARA, FOXM1, FOXO1, ILF2, ILF3, FOXC1, MLLT11, ZBTB17, NR1H3, BAMBI, TRIM28, UBE2V1, ILK, NFATC2, SMAD4, PICALM, HDAC1, PTCH1, RUNX3, NCOA4, RUNX2, HNRNPD, NPAT, NFE2L1, NR1D2, ERBB4, NCOA1, SMAD2, ZFHX3, ZIC1, HIF1A, ZNF423, HIVEP3, RGMB, PSRC1, ATAD2, SMARCD3, ATF7IP, KDM7A, RNF111, GPBP1, CRLF3, TP53INP2, YAF2, KMT2E, SFRP1, AFAP1L2, BANP, CTCFL, SMARCC2, SETD7, CHURC1, NAT14, PHIP, ARNTL2, KAT6B, ESR2, HDAC2, PROX1, CREBBP, KAT6A, TAF15, SMARCC1, MED12, TP53INP1, MED30, ATOH8, RSF1, KLF6, SMAD5, HNRNPAB, NPAS2, CITED1, CITED2, SOST, INPP5K, WAC, NUP85, LGR4, NAA15, TBL1XR1, FOXP3, NIF3L1, EPC1, HIPK2, SMARCAD1, SOX17, ZNF287, GPBP1L1, CHD8, ENY2, BRD7, MED4, PLCB1, MED17, RRN3, EHF, PPARGC1A, RNF14, FZD4, USP22, MAPRE3, RNF6, BTRC, MYRF, THRAP3, MED16, NFE2L3, KLF2, WNT6, NCOA3

GO:0045898

BP

regulation of RNA polymerase II transcriptional preinitiation complex assembly

Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.

ATF7IP

GO:0045899

BP

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.

CREB1, PSMC3, PSMC2, PSMC4, PSMC1, PSMC6, CAND1

GO:0045900

BP

negative regulation of translational elongation

Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.

SRP9

GO:0045901

BP

positive regulation of translational elongation

Any process that activates or increases the frequency, rate or extent of translational elongation.

EIF5A, EIF5A2

GO:0045903

BP

positive regulation of translational fidelity

Any process that increases the ability of the translational apparatus to interpret the genetic code.

RPS9

GO:0045905

BP

positive regulation of translational termination

Any process that activates or increases the frequency, rate or extent of translational termination.

EIF5A, EIF5A2

GO:0045906

BP

negative regulation of vasoconstriction

Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction.

ADM, LEP, BMPR2, APLN

GO:0045907

BP

positive regulation of vasoconstriction

Any process that activates or increases the frequency, rate or extent of vasoconstriction.

EGFR, FGA, FGB, FGG, ICAM1, GJA1, ADRA1D, PTAFR, F2R, AVPR2, OXTR, AKT1, ADRA1A, PTGS2, HRH1, ADRA1B, GJA5, CAV1, TRPM4

GO:0045908

BP

negative regulation of vasodilation

Any process that stops, prevents, or reduces the frequency, rate or extent of vasodilation.

INS, CRP, HMGCR, ADORA1

GO:0045909

BP

positive regulation of vasodilation

Any process that activates or increases the frequency, rate or extent of vasodilation.

EGFR, AGT, INS, HMOX1, GJA1, PTAFR, PTPRM, NOS3, ADM, GJA5, AGTR2, F2RL1, PPARD, PTGDR, GPER1, SCPEP1, APLN

GO:0045910

BP

negative regulation of DNA recombination

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.

MSH3, MSH2, MSH6, BLM

GO:0045916

BP

negative regulation of complement activation

Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.

CD55

GO:0045917

BP

positive regulation of complement activation

Any process that activates or increases the frequency, rate or extent of complement activation.

PHB

GO:0045918

BP

negative regulation of cytolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis.

PF4, BAD

GO:0045919

BP

positive regulation of cytolysis

Any process that activates or increases the frequency, rate or extent of cytolysis.

GPLD1, LILRB1

GO:0045920

BP

negative regulation of exocytosis

Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.

ANXA1, SNCA, STXBP6

GO:0045921

BP

positive regulation of exocytosis

Any process that activates or increases the frequency, rate or extent of exocytosis.

RAB27B, FGA, FGB, FGG, CFTR, RAB5A, RAB9A, RAB27A, NCS1, STXBP5, EXPH5, RAB2B, SYTL4

GO:0045922

BP

negative regulation of fatty acid metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.

INS

GO:0045923

BP

positive regulation of fatty acid metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.

ADIPOQ, GHSR

GO:0045925

BP

positive regulation of female receptivity

Any process that activates or increases the receptiveness of a female to male advances.

THRA, NCOA1

GO:0045926

BP

negative regulation of growth

Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.

MT2A, MT1E, MT1F, MT1G, IGFBP5, MT1H, MT1X, HIF1A, MT1M, PNPT1

GO:0045927

BP

positive regulation of growth

Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.

ZPR1, PPM1F

GO:0045930

BP

negative regulation of mitotic cell cycle

Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.

BRINP1, EGFR, TGFB1, TIMP2, IL10, CDKN1B, GAS1, SMAD3, FOXC1, DLG1, MAD2L1, HECA, TRIM35

GO:0045931

BP

positive regulation of mitotic cell cycle

Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.

USP2, APP, CDK1, EIF4E, ASNS, CCNB1, PRKCA, TAL1, CDC25B, DUSP3, BRCA2, STAT5B, MDM2, PTPN11, EIF4EBP1, SHB, PKN2, SPHK1, USP22, POLDIP2

GO:0045932

BP

negative regulation of muscle contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.

TNNT1

GO:0045943

BP

positive regulation of transcription from RNA polymerase I promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter.

PPP1R15A, ERBB2, UBTF, ATF4

GO:0045944

BP

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

E2F8, MED19, HAX1, TLR4, APBB1, SUPT5H, WWP2, ARNTL, MEIS1, NR5A2, DDX3X, CYR61, NFIB, ITGB1BP1, TNFSF11, BACH1, CASK, PPP1R12A, SMAD7, PLSCR1, OGT, SOX12, HDAC3, TLR3, MAFG, PER1, RIPK2, HOXA2, TBX1, CBFA2T2, KLF4, FOXO3, LDB2, TCF21, TRIAP1, RAD21, MED14, SOX15, PARK2, ZEB2, KDM1A, CCNT1, GREM1, CCNT2, TLR2, BRD4, SHOX2, TBL1X, MITF, LRP5, MAF, LRP6, RPS6KA5, MED6, NFAT5, ABLIM3, TNKS, NFATC1, IL33, EGFR, FOS, MYC, TGFB1, POMC, CGA, FSHB, PTH, TNF, IL1A, IL1B, PF4, ESR1, RAF1, NR3C1, MYCN, TP53, IGF1, APP, SERPINE1, IL6, EDN1, JUN, RB1, PGR, ADRB2, DCN, PFN1, INHBA, MET, NFIC, FGF2, HOXB5, HMGB1, WNT2, PARP1, H2AFZ, UBC, GLI2, GLI3, MYBL1, MYBL2, AR, NR2F1, CD28, THRA, IRF1, EGR2, TOP2A, VDR, ESRRA, BMP2, BMP4, SKI, HGF, HCLS1, DRD2, ETS1, LIF, ETS2, FOSL1, FOSL2, VEGFA, TCF4, TCF3, CREB1, EPCAM, RHOQ, HMGA1, JUNB, JUND, TAL1, CEBPB, DDX5, XBP1, ERCC2, ARF4, EGR1, ATF1, ATF3, ATF4, ELK1, TFEB, WT1, NFKB1, BCL3, IL11, HNF1A, S1PR1, FGFR2, BMP6, IL10, NME2, GAL, NR4A1, ITGA6, YY1, LMO2, HMGB2, ACVR2A, MAPK3, ARNT, PIK3R1, HOXD10, MZF1, RXRB, RBL1, HOXA10, AKT1, OTX2, GTF2H1, CTNNB1, RORA, DDIT3, SOX6, AHR, BMPR1A, ACVR1B, SREBF1, PPARG, ZEB1, RBMX, BRCA1, PBX1, PBX2, STAT3, ETV5, WNT5A, ELK3, CDKN2B, NR4A2, NAMPT, GATA4, NKX2-1, ATRX, NOTCH1, YAP1, ID4, SOX9, NRIP1, SLC11A1, CDK8, CEBPD, GSK3B, MEOX1, LHX2, ETV1, ASCL1, CDK7, SMARCA2, SMARCA4, STAT5B, LUM, GTF2A2, HMGA2, FOSB, CEBPG, SUB1, NR1H2, F2RL1, MLLT10, CDH13, HDAC4, CTBP2, SOX8, FOXL2, CD81, SUMO2, LMO4, RPS27A, UBA52, YBX1, IGBP1, JAG1, PRKDC, ELF3, SMAD3, PKD1, FOXO4, TFAM, HSF1, E2F1, RUNX1, RELB, POU5F1, MEF2A, NRG1, SP3, HHEX, POU3F1, CREM, CEBPZ, RELA, ACVR1, REL, RNASEL, EXOSC9, MEF2C, GABPA, PAX8, SOX4, DLX2, PPARA, FOXM1, PPP3CA, EP300, SREBF2, FOXO1, HYAL2, FOXC1, NR1H3, TARDBP, FADD, MAP2K5, MAPK7, TRIM28, IKZF1, NFATC2, SMAD4, SQSTM1, MED21, RIPK1, HDAC1, PKD2, BMPR2, CBFB, NFYC, CAMK1, IL18, TFDP1, HES1, NFE2L1, LPIN1, MEF2D, MTF1, NFATC4, MORF4L2, PRKD1, PPP2R5B, ANKRD1, PCBP1, RPS6KA1, TEAD2, NCOA2, TWIST1, NCOA1, SMAD2, SMAD1, ADIRF, USF2, ZIC1, HLF, MAPK14, HIF1A, IFI16, ARID4B, DCAF6, PLAG1, JADE1, NIPBL, ATAD2, SLC30A9, CRTC3, RNF111, ASXL2, PID1, SETX, MAVS, AKNA, PCGF5, NLRC5, PPARGC1B, TMPRSS6, CRLF3, SIRT2, MAML2, AHI1, ZNF567, ZBTB38, NFATC2IP, GLIS3, ZMIZ2, FLCN, LILRB1, NCOA7, CTCFL, GABPB2, OSR1, ZNF564, ZFPM2, GLMP, CKAP2, PHIP, ARNTL2, KAT6B, CSRNP3, RTF1, NR4A3, HSPH1, HDAC2, PROX1, CREBBP, EZH1, KAT2B, DDX17, GATA6, SMARCC1, ARHGEF2, MED12, MYDGF, WBP2, ZBED3, ABHD14B, MAML3, ZNF462, IFT74, NR1H4, CITED4, CSRNP1, CCNL2, ZNF382, UHRF1, TCF12, GPER1, TEAD3, MEIS3, PITX2, NPAS2, EPAS1, ARID3A, CITED1, CITED2, PAGR1, SSBP3, HELZ2, TBL1XR1, PRKD2, FOXP3, PEG3, ZNF350, CSRNP2, NUCKS1, EPC1, IKZF4, DHX36, HIPK2, FZD8, RGCC, SOX17, SMYD3, EBF2, BCL2L12, PATZ1, BEX1, TAF9B, CHD8, SLC40A1, HEYL, TCF7L2, ASH1L, MED17, AATF, EHF, GRHL1, CHD7, RERE, PPARGC1A, ASH2L, TCF20, ARMCX3, TBK1, TRPS1, NUFIP1, ZNF639, KLF15, CNOT7, MOSPD1, CCNL1, AGO2, ELF5, CCPG1, MKL2, ZMIZ1, MAFF, MYO6, PLAGL1, TFR2, HDAC5, ZNF148, RUVBL2, HIF3A, THRAP3, KLF13, MTF2, PAXBP1, HEY1, MAFB, KLF2, FHOD1, CHCHD2, NCOA3, CAMTA1

GO:0045945

BP

positive regulation of transcription from RNA polymerase III promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter.

ERBB2, AR, ICE2, CHD8

GO:0045947

BP

negative regulation of translational initiation

Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.

TPR, FMR1, EIF4EBP1, EIF4EBP2, PAIP2, RBM4, EIF2AK4, EIF2B4, AGO2

GO:0045948

BP

positive regulation of translational initiation

Any process that activates or increases the frequency, rate or extent of translational initiation.

DDX3X, POLR2D, CDC123, CCL5, POLR2G, KHDRBS1, EIF2B5, UHMK1, YTHDF1

GO:0045950

BP

negative regulation of mitotic recombination

Any process that inhibits or decreases the rate of DNA recombination during mitosis.

MLH1

GO:0045953

BP

negative regulation of natural killer cell mediated cytotoxicity

Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.

MICA, LILRB1

GO:0045954

BP

positive regulation of natural killer cell mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.

LAMP1, PVR, VAV1, LAG3, IL12A, STAT5B, CADM1

GO:0045955

BP

negative regulation of calcium ion-dependent exocytosis

Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.

NOTCH1, TRIM9

GO:0045956

BP

positive regulation of calcium ion-dependent exocytosis

Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.

CACNA1G, SYT1, STXBP1, ARF1, CDK5

GO:0045957

BP

negative regulation of complement activation, alternative pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway.

CR1

GO:0045959

BP

negative regulation of complement activation, classical pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway.

CR1

GO:0045963

BP

negative regulation of dopamine metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine.

COMT, SNCA

GO:0045964

BP

positive regulation of dopamine metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine.

GPR37, MAOB, ABAT

GO:0045976

BP

negative regulation of mitotic cell cycle, embryonic

Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle.

CTNNB1

GO:0045977

BP

positive regulation of mitotic cell cycle, embryonic

Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle.

HES1

GO:0045986

BP

negative regulation of smooth muscle contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.

ADRB2, PTGS2

GO:0045987

BP

positive regulation of smooth muscle contraction

Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.

ADA, EDN1, ITGA2, CHRM3, EDN2, ADRA1D, F2R, ADRA1A, PTGS2, ADRA1B, NMU, NPY2R, CTTN, SPHK1

GO:0045988

BP

negative regulation of striated muscle contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.

ATP1A2

GO:0045994

BP

positive regulation of translational initiation by iron

Any process involving iron that activates or increases the rate of translational initiation.

TNF

GO:0045995

BP

regulation of embryonic development

Any process that modulates the frequency, rate or extent of embryonic development.

INSR, CDK1, LAMA2, LAMA4, LAMA3, PHLDA2, NIPBL, SOX17, NOCT

GO:0046005

BP

positive regulation of circadian sleep/wake cycle, REM sleep

Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep.

GHRH

GO:0046007

BP

negative regulation of activated T cell proliferation

Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.

PRNP, PRKAR1A, BTN2A2, FOXP3

GO:0046010

BP

positive regulation of circadian sleep/wake cycle, non-REM sleep

Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep.

NPY2R, GHRL

GO:0046022

BP

positive regulation of transcription from RNA polymerase II promoter during mitosis

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis.

ZNF268

GO:0046031

BP

ADP metabolic process

The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate.

AMPD3, BAD

GO:0046032

BP

ADP catabolic process

The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate.

NUDT9

GO:0046033

BP

AMP metabolic process

The chemical reactions and pathways involving AMP, adenosine monophosphate.

AK1, AK4, AK3

GO:0046034

BP

ATP metabolic process

The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.

AK1, ATP1B1, HSPA1A, HSPA1B, ATP6V1B2, AK4, NDUFS1, ATP1A2, VCP, AMPD3, GUK1, BAD, MYH4

GO:0046037

BP

GMP metabolic process

The chemical reactions and pathways involving GMP, guanosine monophosphate.

CASK, DLG4, MPP1, DLG1, GUK1, TJP2

GO:0046039

BP

GTP metabolic process

The chemical reactions and pathways involving GTP, guanosine triphosphate.

GNAI3, RHOQ, AK4, AMPD3, AK3

GO:0046040

BP

IMP metabolic process

The chemical reactions and pathways involving IMP, inosine monophosphate.

ADSS, ADSSL1

GO:0046041

BP

ITP metabolic process

The chemical reactions and pathways involving ITP, inosine triphosphate.

AK3

GO:0046051

BP

UTP metabolic process

The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate.

AK3

GO:0046054

BP

dGMP metabolic process

The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate).

GUK1

GO:0046058

BP

cAMP metabolic process

The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).

PTH, PTHLH

GO:0046060

BP

dATP metabolic process

The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate).

GUK1

GO:0046061

BP

dATP catabolic process

The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate).

ADA, NUDT1, SAMHD1

GO:0046068

BP

cGMP metabolic process

The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate.

PDE9A, RORA

GO:0046069

BP

cGMP catabolic process

The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate.

PDE5A, PDE9A

GO:0046070

BP

dGTP metabolic process

The chemical reactions and pathways involving dGTP, guanosine triphosphate.

DGUOK

GO:0046078

BP

dUMP metabolic process

The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate).

TYMS

GO:0046081

BP

dUTP catabolic process

The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate.

DUT

GO:0046084

BP

adenine biosynthetic process

The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.

PAICS

GO:0046085

BP

adenosine metabolic process

The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.

ACPP, PTGDR

GO:0046086

BP

adenosine biosynthetic process

The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.

NT5E

GO:0046092

BP

deoxycytidine metabolic process

The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.

TK2

GO:0046098

BP

guanine metabolic process

The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.

KDM1A

GO:0046101

BP

hypoxanthine biosynthetic process

The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.

PRPS1

GO:0046103

BP

inosine biosynthetic process

The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.

ADA

GO:0046104

BP

thymidine metabolic process

The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.

TK2, TK1

GO:0046108

BP

uridine metabolic process

The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.

UPP2

GO:0046111

BP

xanthine biosynthetic process

The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.

ADA

GO:0046121

BP

deoxyribonucleoside catabolic process

The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside).

DERA

GO:0046122

BP

purine deoxyribonucleoside metabolic process

The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside).

DGUOK

GO:0046130

BP

purine ribonucleoside catabolic process

The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule.

ENPP4

GO:0046134

BP

pyrimidine nucleoside biosynthetic process

The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).

TYMS, UMPS, CAD, DCTD, DUT, DHODH