GO ID |
Ontology |
GO Term |
Term Definition |
Proteins |
GO:0044331
|
BP
|
cell-cell adhesion mediated by cadherin
|
The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.
|
CDH2,
CDHR2,
MMP24
|
GO:0044332
|
BP
|
Wnt signaling pathway involved in dorsal/ventral axis specification
|
The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis.
|
LRP5,
LRP6
|
GO:0044334
|
BP
|
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
|
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition.
|
CTNNB1,
TCF7L2
|
GO:0044335
|
BP
|
canonical Wnt signaling pathway involved in neural crest cell differentiation
|
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in neural crest cell differentiation.
|
LRP6
|
GO:0044336
|
BP
|
canonical Wnt signaling pathway involved in negative regulation of apoptotic process
|
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process.
|
CTNNB1
|
GO:0044337
|
BP
|
canonical Wnt signaling pathway involved in positive regulation of apoptotic process
|
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of apoptotic process.
|
GSK3B
|
GO:0044338
|
BP
|
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
|
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation.
|
WNT3
|
GO:0044339
|
BP
|
canonical Wnt signaling pathway involved in osteoblast differentiation
|
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation.
|
WNT3
|
GO:0044340
|
BP
|
canonical Wnt signaling pathway involved in regulation of cell proliferation
|
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation.
|
LRP6
|
GO:0044341
|
BP
|
sodium-dependent phosphate transport
|
The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.
|
SLC20A2,
SLC20A1
|
GO:0044342
|
BP
|
type B pancreatic cell proliferation
|
The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin.
|
IGFBP3,
IGFBP4,
IGFBP5,
BAD
|
GO:0044344
|
BP
|
cellular response to fibroblast growth factor stimulus
|
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
|
ITGB1BP1,
TBX1,
SNAI2,
COL1A1,
CXCL8,
TDGF1,
CCL2,
CCL5,
CD44,
NR4A1,
ZFP36,
SNCA,
ZFP36L2,
GCLC,
GCLM,
STAR,
EGR3,
ZFP36L1,
HYAL2,
POSTN,
DSTYK,
SETX,
SFRP1,
CDC5L,
DLL4,
KDM5B
|
GO:0044345
|
BP
|
stromal-epithelial cell signaling involved in prostate gland development
|
The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development.
|
SFRP1
|
GO:0044346
|
BP
|
fibroblast apoptotic process
|
Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.
|
MYC,
CUL3
|
GO:0044351
|
BP
|
macropinocytosis
|
An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
|
MAPKAPK2,
LRRC16A,
SNX33,
DOCK2,
PYCARD
|
GO:0044375
|
BP
|
regulation of peroxisome size
|
Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
|
PEX11B
|
GO:0044380
|
BP
|
protein localization to cytoskeleton
|
A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.
|
FAM83H
|
GO:0044387
|
BP
|
negative regulation of protein kinase activity by regulation of protein phosphorylation
|
The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase.
|
NPM1,
PPM1F,
ADARB1,
DUSP26,
CORO1C,
DUSP10
|
GO:0044406
|
BP
|
adhesion of symbiont to host
|
The attachment of a symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
ICAM1,
SCARB1
|
GO:0044458
|
BP
|
motile cilium assembly
|
The assembly of a motile cilium, a cilium that contains a regular longitudinal array of axonemal microtubules. In vertebrates, motile cilia are usually formed around a 9 + 2 microtubule core structure. Motile cilia are often found in tissues where propagation of fluid is necessary for proper organ development or function.
|
BBOF1,
CC2D2A
|
GO:0044524
|
BP
|
protein sulfhydration
|
The modification of a protein amino acid by the addition of sulfur.
|
CTH
|
GO:0044539
|
BP
|
long-chain fatty acid import
|
The directed movement of long-chain fatty acids into a cell or organelle. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
|
SLC27A2,
FABP3,
CD36,
ACSL1,
SLC27A4,
SPX
|
GO:0044550
|
BP
|
secondary metabolite biosynthetic process
|
The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
|
KMO,
CYP11A1,
CYP11B1,
CYP11B2
|
GO:0044565
|
BP
|
dendritic cell proliferation
|
The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
|
AZI2,
TBK1
|
GO:0044597
|
BP
|
daunorubicin metabolic process
|
The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer.
|
AKR7A2,
AKR1B1,
AKR1C3,
AKR1C2,
AKR1C1
|
GO:0044598
|
BP
|
doxorubicin metabolic process
|
The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy.
|
AKR7A2,
AKR1B1,
AKR1C3,
AKR1C2,
AKR1C1
|
GO:0044691
|
BP
|
tooth eruption
|
The tooth development process in which the teeth enter the mouth and become visible.
|
COL1A1,
ADAMTS5
|
GO:0044702
|
BP
|
single organism reproductive process
|
A biological process that directly contributes to the process of producing new individuals, involving a single organism.
|
NPR2
|
GO:0044708
|
BP
|
single-organism behavior
|
The specific behavior of a single organism in response to external or internal stimuli.
|
MBD5
|
GO:0044721
|
BP
|
protein import into peroxisome matrix, substrate release
|
The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane.
|
PEX14
|
GO:0044752
|
BP
|
response to human chorionic gonadotropin
|
Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus.
|
GCLC,
GCLM
|
GO:0044770
|
BP
|
cell cycle phase transition
|
The cell cycle process by which a cell commits to entering the next cell cycle phase.
|
CDC7,
PTPRC,
TIPIN,
TIMELESS
|
GO:0044772
|
BP
|
mitotic cell cycle phase transition
|
The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
|
CKS2,
NEK11,
LZTS1
|
GO:0044774
|
BP
|
mitotic DNA integrity checkpoint
|
A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.
|
TOP2A
|
GO:0044782
|
BP
|
cilium organization
|
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
|
CFAP126,
MNS1,
TTC17
|
GO:0044783
|
BP
|
G1 DNA damage checkpoint
|
A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase in the cell cycle in response to DNA damage.
|
WAC
|
GO:0044791
|
BP
|
positive regulation by host of viral release from host cell
|
A process in which a host organism activates or increases the frequency, rate or extent of the release of a virus with which it is infected, from its cells.
|
PC,
CAV2,
ZNF502,
VAPA
|
GO:0044794
|
BP
|
positive regulation by host of viral process
|
A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected.
|
APOE,
PC,
PPIB,
CFL1,
CAV2,
ZNF502
|
GO:0044804
|
BP
|
nucleophagy
|
A selective form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded.
|
ATG12,
WIPI1,
ATG2B,
WDR45,
WIPI2
|
GO:0044806
|
BP
|
G-quadruplex DNA unwinding
|
The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'.
|
PIF1
|
GO:0044828
|
BP
|
negative regulation by host of viral genome replication
|
A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication.
|
PARK2,
VAPA,
EIF2AK4
|
GO:0044829
|
BP
|
positive regulation by host of viral genome replication
|
A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication.
|
PPIB,
STOM,
NUCKS1,
YTHDC2,
VAPA
|
GO:0044830
|
BP
|
modulation by host of viral RNA genome replication
|
A process in which a host organism modulates the frequency, rate or extent of viral RNA genome replication.
|
FMR1
|
GO:0044849
|
BP
|
estrous cycle
|
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
|
GNRH1,
ANXA1,
PCNA,
ETS1,
EGR1,
OXTR,
OPRL1,
NCOA1,
HAS2
|
GO:0044854
|
BP
|
plasma membrane raft assembly
|
The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft.
|
FLOT1
|
GO:0044860
|
BP
|
protein localization to plasma membrane raft
|
A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft.
|
CAV1
|
GO:0044861
|
BP
|
protein transport into plasma membrane raft
|
The directed movement of a protein into a plasma membrane raft.
|
ATP1B1,
CLIP1
|
GO:0044869
|
BP
|
negative regulation by host of viral exo-alpha-sialidase activity
|
The process in which an organism effects a change in symbiont exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein.
|
APCS,
PTX3
|
GO:0044871
|
BP
|
negative regulation by host of viral glycoprotein metabolic process
|
A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral glycoprotein metabolic process.
|
APCS,
PTX3
|
GO:0045004
|
BP
|
DNA replication proofreading
|
Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.
|
POLD1
|
GO:0045006
|
BP
|
DNA deamination
|
The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil.
|
EXOSC6,
EXOSC4,
EXOSC3
|
GO:0045007
|
BP
|
depurination
|
The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar.
|
MPG,
MUTYH
|
GO:0045008
|
BP
|
depyrimidination
|
The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar.
|
MBD4,
UNG,
NTHL1,
TDG,
SMUG1
|
GO:0045010
|
BP
|
actin nucleation
|
The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
|
LMOD1,
ARPC4
|
GO:0045016
|
BP
|
mitochondrial magnesium ion transport
|
The transport of magnesium ions (Mg2+) into, out of or within a mitochondrion. Transport across the mitochondrial membranes is mediated by a mitochondrial inner membrane protein.
|
MRS2
|
GO:0045019
|
BP
|
negative regulation of nitric oxide biosynthetic process
|
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
IL10,
ATP2B4,
TSPO,
CAV1,
RGN,
PTGIS,
KHSRP
|
GO:0045022
|
BP
|
early endosome to late endosome transport
|
The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
|
RAB5A,
RAB7A,
EMP2,
SNX16,
EEA1,
HOOK3,
PIK3C3,
HOOK2,
ANKRD27,
AKTIP
|
GO:0045023
|
BP
|
G0 to G1 transition
|
The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression.
|
MDM4,
CDK3
|
GO:0045026
|
BP
|
plasma membrane fusion
|
The joining of two or more lipid bilayer membranes that surround a cell.
|
TIE1,
NSF,
VASH2
|
GO:0045039
|
BP
|
protein import into mitochondrial inner membrane
|
The process comprising the import of proteins into the mitochondrion from outside the organelle and their insertion into the mitochondrial inner membrane. The translocase of the outer membrane complex mediates the passage of these proteins across the outer membrane, after which they are guided by either of two inner membrane translocase complexes into their final destination in the inner membrane.
|
NDUFA13
|
GO:0045040
|
BP
|
protein import into mitochondrial outer membrane
|
The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes.
|
HSP90AA1,
HSPA4,
TOMM22,
TOMM7,
SAMM50
|
GO:0045046
|
BP
|
protein import into peroxisome membrane
|
The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import.
|
PEX3,
RAB8B
|
GO:0045047
|
BP
|
protein targeting to ER
|
The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.
|
SRP14,
SEC61G,
SRP54,
SEC61A1,
SPCS2
|
GO:0045048
|
BP
|
protein insertion into ER membrane
|
The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.
|
ASNA1
|
GO:0045053
|
BP
|
protein retention in Golgi apparatus
|
The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known.
|
VPS13C,
SORL1
|
GO:0045054
|
BP
|
constitutive secretory pathway
|
A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space.
|
RAB11B
|
GO:0045055
|
BP
|
regulated exocytosis
|
A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
|
TMED10,
RAB31,
RAB11B,
RAB11FIP1,
RAB11FIP2
|
GO:0045056
|
BP
|
transcytosis
|
The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.
|
PTAFR,
MFSD2A,
MAL2,
VPS35
|
GO:0045058
|
BP
|
T cell selection
|
The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
|
CD4,
CD74,
CD1D
|
GO:0045059
|
BP
|
positive thymic T cell selection
|
The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
|
CD74,
STK11,
DOCK2
|
GO:0045060
|
BP
|
negative thymic T cell selection
|
The process of elimination of immature T cells in the thymus which react strongly with self-antigens.
|
CD74,
GLI3,
CD28,
FAS,
DOCK2
|
GO:0045063
|
BP
|
T-helper 1 cell differentiation
|
The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.
|
HMGB1,
RELB,
IL18R1,
SEMA4A
|
GO:0045064
|
BP
|
T-helper 2 cell differentiation
|
The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4.
|
BCL3
|
GO:0045066
|
BP
|
regulatory T cell differentiation
|
The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types.
|
TGFB1,
CD28
|
GO:0045069
|
BP
|
regulation of viral genome replication
|
Any process that modulates the frequency, rate or extent of viral genome replication.
|
BCL2,
DDX5,
PPIA
|
GO:0045070
|
BP
|
positive regulation of viral genome replication
|
Any process that activates or increases the frequency, rate or extent of viral genome replication.
|
NR5A2,
DDX3X,
TRIM38,
PPIH,
VAPB,
STAU1,
CD28,
TOP2A,
CCL5,
NOTCH1,
RAD23A,
PPIA,
SRPK2,
ADARB1,
PPID,
PKN2,
LARP1,
SRPK1,
HACD3,
PPIE
|
GO:0045071
|
BP
|
negative regulation of viral genome replication
|
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
|
PLSCR1,
TNF,
SLPI,
ISG15,
IFITM1,
CCL5,
SRPK2,
IFITM3,
RNASEL,
BST2,
ILF3,
IFI16,
MAVS,
PROX1,
ISG20,
SRPK1,
TRIM6,
APOBEC3G
|
GO:0045075
|
BP
|
regulation of interleukin-12 biosynthetic process
|
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12.
|
MAST2
|
GO:0045077
|
BP
|
negative regulation of interferon-gamma biosynthetic process
|
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.
|
INHA,
INHBA,
CD276,
LILRB1,
FOXP3
|
GO:0045078
|
BP
|
positive regulation of interferon-gamma biosynthetic process
|
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.
|
TLR3,
CEBPG,
CD276
|
GO:0045079
|
BP
|
negative regulation of chemokine biosynthetic process
|
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.
|
IL6,
SIGIRR
|
GO:0045080
|
BP
|
positive regulation of chemokine biosynthetic process
|
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.
|
TLR3,
TNF,
IL1B,
HMOX1,
EGR1,
WNT5A
|
GO:0045081
|
BP
|
negative regulation of interleukin-10 biosynthetic process
|
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10.
|
TRIB2
|
GO:0045082
|
BP
|
positive regulation of interleukin-10 biosynthetic process
|
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10.
|
BCL3
|
GO:0045083
|
BP
|
negative regulation of interleukin-12 biosynthetic process
|
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12.
|
NFKB1
|
GO:0045084
|
BP
|
positive regulation of interleukin-12 biosynthetic process
|
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12.
|
TLR4,
IRF1,
RELA
|
GO:0045085
|
BP
|
negative regulation of interleukin-2 biosynthetic process
|
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
|
LAG3,
ZFP36,
CD276,
FOXP3
|
GO:0045086
|
BP
|
positive regulation of interleukin-2 biosynthetic process
|
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
|
IL1A,
IL1B,
CD4,
CD28,
STAT5B,
PRKCQ,
GLMN
|
GO:0045087
|
BP
|
innate immune response
|
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
IGLL5,
TLR4,
PIK3CD,
DDX3X,
POLR3G,
HMGB3,
TLR3,
RIPK2,
TYROBP,
TLR5,
TLR2,
JAK2,
TRIM13,
CRCP,
ATG12,
VNN1,
BCL10,
C1R,
IFNA1 ,
FGA,
FGB,
APCS,
C1QA,
ANG,
SLPI,
ANXA1,
S100B,
CYBB,
IFNA16,
APP,
S100A8,
SERPING1,
CFI,
FYN,
S100A9,
CSF1R,
LYN,
CD55,
CD14,
KRT16,
HMGB1,
FGR,
C1S,
C4A,
C4B,
UBC,
SAA1,
CLU,
MBL2,
DEFA4,
C6,
HLA-E,
MIF,
CD46,
CD1D,
CR1,
LGALS3,
NFKB1,
NCF2,
JAK1,
PTX3,
HMGB2,
CD6,
CORO1A,
S100A7,
PPARG,
CSK,
ABL2,
SYK,
PIK3CG,
CASP4,
IRAK1,
JAK3,
CAPZA1,
CRISP3,
F2RL1,
TIRAP,
B2M,
RPS27A,
UBA52,
SRPK2,
ADARB1,
LCN2,
RELB,
REL,
PTK2,
C1QBP,
TNK2,
BST2,
TRIM26,
FADD,
TRIM28,
IFIT5,
SERINC3,
TRIM14,
TRIM25,
PRKD1,
TLR1,
IFI16,
TKFC,
COLEC12,
SDHAF4,
SUSD4,
STYK1,
SARM1,
IL34,
MAVS,
SERINC5,
NLRC5,
IFNE,
SIRT2,
DEFB104A,
CLEC4D,
SEC14L1,
ARHGEF2,
MR1,
PPP1R14B,
ITCH,
PGLYRP2,
NR1H4,
SRPK1,
GPER1,
MAP3K5,
CNPY3,
SPON2,
POLR3C,
TRIM62,
LGR4,
CLEC7A,
TRIM8,
CD244,
TRIM4,
TOLLIP,
POLR3F,
APOBEC3G,
CD209,
TREM1,
IL1RAP,
POLR3B,
C1RL,
DMBT1,
APOBEC3B,
TBK1,
FBXO9,
PYCARD,
PADI4,
TRIM35,
POLR3K
|
GO:0045088
|
BP
|
regulation of innate immune response
|
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
|
FGR,
IRF1,
TIRAP,
XIAP,
BIRC3,
TKFC,
ERAP1,
PTPN22,
SAMHD1
|
GO:0045089
|
BP
|
positive regulation of innate immune response
|
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
|
EREG,
PLSCR1,
POLR3G,
COCH,
MMP2,
CCL5,
CD1D,
HMGB2,
POLR3C,
POLR3F,
POLR3B
|
GO:0045091
|
BP
|
regulation of single stranded viral RNA replication via double stranded DNA intermediate
|
Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.
|
CXCL8
|
GO:0045103
|
BP
|
intermediate filament-based process
|
Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins.
|
SYNC
|
GO:0045104
|
BP
|
intermediate filament cytoskeleton organization
|
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins.
|
TOR1A,
RAF1,
KRT18,
KRT16,
KRT3,
CSNK1A1,
ATXN3,
DST,
FAM83H
|
GO:0045109
|
BP
|
intermediate filament organization
|
Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
|
DNAJB6,
VIM,
DSP,
DES,
KRT9,
AGFG1,
KRT17,
MTM1
|
GO:0045110
|
BP
|
intermediate filament bundle assembly
|
The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs.
|
PKP2
|
GO:0045112
|
BP
|
integrin biosynthetic process
|
The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules.
|
COL5A1
|
GO:0045113
|
BP
|
regulation of integrin biosynthetic process
|
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.
|
S100A9
|
GO:0045116
|
BP
|
protein neddylation
|
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
|
UBE2M,
RBX1,
NAE1,
NEDD8,
DCUN1D4,
DCUN1D1
|
GO:0045123
|
BP
|
cellular extravasation
|
The migration of a leukocyte from the blood vessels into the surrounding tissue.
|
ITGB2
|