GO:0035965

BP

cardiolipin acyl-chain remodeling

Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids.

PLA2G4A, HADHB, LCLAT1

GO:0035967

BP

cellular response to topologically incorrect protein

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.

HDAC6

GO:0035970

BP

peptidyl-threonine dephosphorylation

The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.

PPM1G, PPM1B, DUSP1, PPM1F, DUSP5, DUSP18, PPM1E, PDP1

GO:0035971

BP

peptidyl-histidine dephosphorylation

The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine.

PHPT1

GO:0035978

BP

histone H2A-S139 phosphorylation

The modification of histone H2A by the addition of an phosphate group to a serine residue at position 139 of the histone.

HMGA2

GO:0035984

BP

cellular response to trichostatin A

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus.

MEF2C, EZH2

GO:0035986

BP

senescence-associated heterochromatin focus assembly

The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes.

HMGA1, HMGA2

GO:0035987

BP

endodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.

HSBP1, FN1, VTN, ITGB2, ITGAV, LAMB1, MMP2, INHBA, COL4A2, ITGA5, COL11A1, COL6A1, MMP9, ITGB5, MMP8, MMP14, MMP15, HMGA2, LAMA3, COL12A1

GO:0035988

BP

chondrocyte proliferation

The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.

CTGF, MMP14, MMP16, STC1, HMGA2

GO:0035989

BP

tendon development

The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.

COL11A1, COL5A1

GO:0035990

BP

tendon cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.

BMP4

GO:0035993

BP

deltoid tuberosity development

The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase.

BMP4, PITX2

GO:0035994

BP

response to muscle stretch

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.

FOS, RAF1, EDN1, JUN, GPI, DMD, NFKB1, RELA, ANKRD1, MAPK14, RYR2

GO:0035995

BP

detection of muscle stretch

The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal.

TTN

GO:0035999

BP

tetrahydrofolate interconversion

The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.

TYMS, MTHFD1, SHMT1, MTHFR, MTHFS, MTHFD1L, MTHFD2L

GO:0036003

BP

positive regulation of transcription from RNA polymerase II promoter in response to stress

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

MUC1, ATF4, MAPK7, GCN1, KLF2

GO:0036006

BP

cellular response to macrophage colony-stimulating factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus.

CSF1R, CCL2

GO:0036010

BP

protein localization to endosome

A process in which a protein is transported to, or maintained in, a location within an endosome.

ACAP2, TOLLIP, TMEM30A

GO:0036016

BP

cellular response to interleukin-3

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus.

MT2A, GSK3B

GO:0036017

BP

response to erythropoietin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis.

HAMP

GO:0036018

BP

cellular response to erythropoietin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus.

MT2A, MT1X

GO:0036023

BP

embryonic skeletal limb joint morphogenesis

The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb.

CTNNB1, OSR1

GO:0036035

BP

osteoclast development

The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

ANXA2, FOXP1

GO:0036037

BP

CD8-positive, alpha-beta T cell activation

The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

HLA-E

GO:0036060

BP

slit diaphragm assembly

The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.

PTPRO

GO:0036065

BP

fucosylation

The covalent attachment of a fucosyl group to an acceptor molecule.

FUT1, FUT4, FUT2

GO:0036066

BP

protein O-linked fucosylation

The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage.

THBS1, CFP, ADAMTSL4, SPON1, SLC35C2, ADAMTS7, ADAMTS5

GO:0036071

BP

N-glycan fucosylation

The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains.

FUT8

GO:0036089

BP

cleavage furrow formation

Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.

RHOA, SNX33, AURKB, SNX18, SNX9

GO:0036091

BP

positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

ATF4, MT3, SESN2

GO:0036092

BP

phosphatidylinositol-3-phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.

PIK3CD, PIK3C2A, SYNJ2, INPP4B, SYNJ1, FGF18, FGF19, FGF2, FGFR1, FGF7, FGFR2, PIK3R1, FGF9, IRS1, PIK3CA, PIK3CB, PIK3CG, GRB2, PTPN11, GAB1, PIK3C3, FRS2, INPP4A, PIK3R4, KL, PIKFYVE, IRS2

GO:0036109

BP

alpha-linolenic acid metabolic process

The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.

ACOT8, FADS1, FADS2, SCP2, ACSL1, HSD17B4, ACOX1, ELOVL1, ELOVL5

GO:0036111

BP

very long-chain fatty-acyl-CoA metabolic process

The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22.

HSD17B4

GO:0036112

BP

medium-chain fatty-acyl-CoA metabolic process

The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.

HSD17B4

GO:0036114

BP

medium-chain fatty-acyl-CoA catabolic process

The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.

ACOT7

GO:0036116

BP

long-chain fatty-acyl-CoA catabolic process

The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

ACOT7

GO:0036120

BP

cellular response to platelet-derived growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.

FYN, PDGFRB, CCL2, CREB1, CCNA2, RDX, IQGAP1, HAS2, CORO1B, PDGFD, ERRFI1

GO:0036123

BP

histone H3-K9 dimethylation

The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone.

SUV39H2

GO:0036124

BP

histone H3-K9 trimethylation

The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone.

ARID4B, SUV39H2

GO:0036145

BP

dendritic cell homeostasis

The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.

GPR183

GO:0036148

BP

phosphatidylglycerol acyl-chain remodeling

Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains.

PLA2G2A, PLA2G5, PLA2G4A, LPGAT1, PLA2G12A, CRLS1

GO:0036149

BP

phosphatidylinositol acyl-chain remodeling

Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains.

PLA2G2A, PLA2G5, PLA2G4A, PLA2G16, MBOAT7, PLA2G12A, PLA2G4C

GO:0036150

BP

phosphatidylserine acyl-chain remodeling

Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains.

PLA2G2A, PLA2G5, PLA2G4A, PLA2G16, LPCAT3, PLA2G12A

GO:0036151

BP

phosphatidylcholine acyl-chain remodeling

Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains.

DBI, PLA2G2A, PLA2G5, PLA2G4A, PLA2G16, LPCAT3, MBOAT2, LPCAT2, PLA2G12A, PNPLA8, PLA2G4C

GO:0036152

BP

phosphatidylethanolamine acyl-chain remodeling

Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains.

PLA2G2A, PLA2G5, PLA2G4A, PLA2G16, LPCAT3, MBOAT2, PLA2G12A, PNPLA8, PLA2G4C

GO:0036153

BP

triglyceride acyl-chain remodeling

Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains.

PNPLA3

GO:0036155

BP

acylglycerol acyl-chain remodeling

Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains.

PNPLA2, DGAT2, MGLL, PNPLA3

GO:0036158

BP

outer dynein arm assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.

ARMC4, DNAAF5, CCDC103, DNAH5, DNAI1

GO:0036159

BP

inner dynein arm assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.

CCDC42B, DNAAF5, CCDC103, DNAH1, TEKT2

GO:0036164

BP

cell-abiotic substrate adhesion

The attachment of a cell to an underlying abiotic (non-living) substrate via adhesion molecules.

ID1

GO:0036179

BP

osteoclast maturation

A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes.

FAM20C

GO:0036211

BP

protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

PARP1

GO:0036228

BP

protein targeting to nuclear inner membrane

The process of targeting a protein to, and inserting it into, the nuclear inner membrane; usually uses signals contained within the protein.

NUP155

GO:0036250

BP

peroxisome transport along microtubule

The directed movement of a peroxisome along a microtubule, mediated by motor proteins.

PEX14

GO:0036257

BP

multivesicular body organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.

RAB27A

GO:0036258

BP

multivesicular body assembly

The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.

VPS37C, CHMP2A, VPS4B, STAM2, IST1, RAB11A, VPS37A, PDCD6IP, STAM, MVB12A, CHMP4B, VTA1

GO:0036289

BP

peptidyl-serine autophosphorylation

The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein.

ERN1, MAP2K2, RIPK1, PINK1

GO:0036292

BP

DNA rewinding

The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA.

ANXA1

GO:0036294

BP

cellular response to decreased oxygen levels

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.

CPEB4

GO:0036297

BP

interstrand cross-link repair

Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.

STRA13, FANCG, RAD51D, RNF8, USP1, ERCC1, UBC, RPA3, RPS27A, UBA52, FAAP100, FAAP20, FANCM, APITD1, FANCB, ATRIP, ERCC4, EME1, RAD51AP1, DCLRE1C, FANCD2, NUCKS1, FANCE, UBE2T, FANCI, FAN1

GO:0036302

BP

atrioventricular canal development

The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle.

PTPN11, SMAD4, HAS2, CHD7

GO:0036303

BP

lymph vessel morphogenesis

The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph.

VEGFA, PKD1

GO:0036304

BP

umbilical cord morphogenesis

The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta.

HEY1

GO:0036309

BP

protein localization to M-band

Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere.

ANK2

GO:0036315

BP

cellular response to sterol

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus.

RORA

GO:0036324

BP

vascular endothelial growth factor receptor-2 signaling pathway

Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.

PDCD6

GO:0036333

BP

hepatocyte homeostasis

Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules.

EZH2

GO:0036335

BP

intestinal stem cell homeostasis

Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells.

LGR4

GO:0036336

BP

dendritic cell migration

The movement of a dendritic cell within or between different tissues and organs of the body.

CDC42, EPS8, DOCK8

GO:0036342

BP

post-anal tail morphogenesis

The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.

WNT5A, TCF15, TMED2, MED12, CHST11

GO:0036343

BP

psychomotor behavior

The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument.

DPP4

GO:0036344

BP

platelet morphogenesis

Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.

ACTN1

GO:0036353

BP

histone H2A-K119 monoubiquitination

The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.

TRIM37

GO:0036363

BP

transforming growth factor beta activation

The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms.

LTBP3

GO:0036371

BP

protein localization to T-tubule

A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.

ANK2

GO:0036376

BP

sodium ion export from cell

The directed movement of sodium ions out of a cell.

ATP1B1, ATP1A2, ATP12A, ATP1B3

GO:0036378

BP

calcitriol biosynthetic process from calciol

Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.

CYP27B1, CYP3A4, CYP2R1

GO:0036399

BP

TCR signalosome assembly

The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome.

STK11

GO:0036404

BP

conversion of ds siRNA to ss siRNA

The process in which double-stranded small interfering RNA (ds siRNA) molecules are converted to single-stranded small interfering RNA (ss siRNA).

DICER1

GO:0036413

BP

histone H3-R26 citrullination

The hydrolysis of peptidyl-arginine to form peptidyl-citrulline at position 26 in histone H3.

PADI4

GO:0036414

BP

histone citrullination

The hydrolysis of peptidyl-arginine to form peptidyl-citrulline on a histone protein.

PADI4

GO:0036438

BP

maintenance of lens transparency

A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina.

MUC5AC, FOXC1, GCNT2, CHMP4B

GO:0036444

BP

calcium ion transmembrane import into mitochondrion

A process in which a calcium ion (Ca2+) is transported from one side of a membrane to the other into the mitochondrion by means of some agent such as a transporter or pore.

MICU2, MCUR1, SLC25A23

GO:0036462

BP

TRAIL-activated apoptotic signaling pathway

An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface.

FADD, CASP8

GO:0036465

BP

synaptic vesicle recycling

The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane.

RAB5A

GO:0036481

BP

intrinsic apoptotic signaling pathway in response to hydrogen peroxide

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2).

PDCD10

GO:0036486

BP

ventral trunk neural crest cell migration

The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta.

NRP1, SEMA3A

GO:0036492

BP

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.

EIF2AK4

GO:0036494

BP

positive regulation of translation initiation in response to endoplasmic reticulum stress

Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.

DNAJC3

GO:0036496

BP

regulation of translational initiation by eIF2 alpha dephosphorylation

Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha.

PPP1R15A, PPP1CA

GO:0036498

BP

IRE1-mediated unfolded protein response

A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.

CTDSP2, GOSR2, TPP1, ASNA1, KDELR3, ERN1, SEC31A, LMNA, SULT1A3, HSPA5, XBP1, SSR1, ACADVL, HDGF, SEC61G, ATP6V0D1, SEC61A1, GFPT1, ZBTB17, DNAJC3, DCTN1, PDIA5, CUL7, PDIA6, PPP2R5B, WIPI1, SYVN1, EDEM1, MYDGF, SEC62, TSPYL2, SEC61A2, FKBP14, DNAJB9, SEC63, TLN1, HYOU1, SRPRB

GO:0036499

BP

PERK-mediated unfolded protein response

A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.

EIF2S1, ASNS, IGFBP1, CXCL8, HSPA5, CCL2, ATF3, ATF4, DDIT3

GO:0036500

BP

ATF6-mediated unfolded protein response

A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.

HSPA5, HSP90B1, XBP1, ATF6, CALR, DDIT3

GO:0036503

BP

ERAD pathway

The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

PARK2, VCP, TRIM25, SYVN1, RHBDD1, SEL1L, AMFR, STUB1

GO:0036508

BP

protein alpha-1,2-demannosylation

The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein.

MAN1B1

GO:0036509

BP

trimming of terminal mannose on B branch

The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.

MAN1B1

GO:0036510

BP

trimming of terminal mannose on C branch

The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.

EDEM1

GO:0036514

BP

dopaminergic neuron axon guidance

The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues.

CELSR3

GO:0036515

BP

serotonergic neuron axon guidance

The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues.

CELSR3

GO:0036517

BP

chemoattraction of serotonergic neuron axon

The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal.

WNT5A