GO:0042416

BP

dopamine biosynthetic process

The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.

GPR37, TH, SNCA, NR4A2, AGTR2, TGFB2

GO:0042417

BP

dopamine metabolic process

The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.

PARK2, DRD2, GRIN2A, SNCAIP

GO:0042418

BP

epinephrine biosynthetic process

The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.

TH, PNMT

GO:0042420

BP

dopamine catabolic process

The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.

MAOA, COMT, MAOB

GO:0042421

BP

norepinephrine biosynthetic process

The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.

TH, INSM1

GO:0042423

BP

catecholamine biosynthetic process

The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.

TH, PNMT

GO:0042426

BP

choline catabolic process

The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.

ALDH7A1, SLC44A1, DMGDH, SARDH

GO:0042427

BP

serotonin biosynthetic process

The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.

TPH2

GO:0042428

BP

serotonin metabolic process

The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.

SRD5A1, GRIN2A, BTBD9

GO:0042438

BP

melanin biosynthetic process

The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.

TYR, DDT, PMEL, TRPC1, CITED1, SLC45A2, MYO5A

GO:0042445

BP

hormone metabolic process

The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.

LEP, ALDH9A1, PTPN11

GO:0042446

BP

hormone biosynthetic process

The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.

CYP17A1, FDX1, HFE, DIO2, DUOX2, DUOX1

GO:0042447

BP

hormone catabolic process

The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.

ACE, IDE, ECE1

GO:0042448

BP

progesterone metabolic process

The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.

CYP17A1, SRD5A1, AKR1C3, STAT5B, AKR1C2, AKR1C1, DHRS9

GO:0042462

BP

eye photoreceptor cell development

Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.

TH, VEGFA, PRKCI, CRB1, RDH13

GO:0042471

BP

ear morphogenesis

The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.

TBX1, NIPBL

GO:0042472

BP

inner ear morphogenesis

The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.

SOBP, INSIG1, TBX1, SPRY2, FZD6, BCR, FGFR1, COL11A1, FGFR2, EPHB2, FGF9, ALDH1A3, DLX5, PAX8, ABR, ZIC1, CHD7, MAFB

GO:0042473

BP

outer ear morphogenesis

The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull.

TBX1, PRKRA, FGFR1, MAPK3, MAPK1, HOXA1, TWIST1

GO:0042474

BP

middle ear morphogenesis

The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).

INSIG1, HOXA2, TBX1, PRKRA, EDN1, FGFR1, NAGLU, RPL38, TSHZ1, OSR1

GO:0042475

BP

odontogenesis of dentin-containing tooth

The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.

TBX1, BCL2L11, LRP6, CA2, NFIC, GLI2, GLI3, BMP2, BMP4, TNC, CTNNA1, CTNNB1, NF2, ADM, BSG, BMPR1A, DLX2, BAX, FOXC1, HDAC1, ACVR2B, RUNX2, ANKRD11, SOSTDC1, HDAC2, PITX2, WNT6

GO:0042476

BP

odontogenesis

The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.

BGLAP, LAMB1, COL1A2, INHBA, BMP4, ZNF22, SDC1, PAM, FGFR2, TGFB2, ID3, TWIST1, OSR1, AQP3, PITX2, MYO5A

GO:0042482

BP

positive regulation of odontogenesis

Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth.

TGFB1, EDN1, BMP2

GO:0042487

BP

regulation of odontogenesis of dentin-containing tooth

Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates.

BMP2, BMP4, RUNX2

GO:0042489

BP

negative regulation of odontogenesis of dentin-containing tooth

Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx.

TNFRSF11B

GO:0042490

BP

mechanoreceptor differentiation

The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system.

NTRK1, NTRK2

GO:0042491

BP

auditory receptor cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an auditory hair cell.

JAG1

GO:0042493

BP

response to drug

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

TNFRSF11B, ACACB, KCNK3, XPO1, PFAS, NPC1, GNPAT, ABCC4, PAX4, DAB1, BCAR3, SRP72, NDUFA10, ABCA1, CBX7, LDHA, PNP, ADA, ASS1, CST3, FOS, MYC, TGFB1, PTH, COL1A1, APOA1, APOA2, BGLAP, AMH, ANXA1, NTRK1, CYP1A1, TYMS, CYBB, APOD, CYP2E1, IL6, ICAM1, JUN, FABP3, FYN, CDK1, LPL, HSP90AA1, LYN, THBS1, INHBA, LGALS1, BCL2, MGST1, HSPD1, TOP1, CDK4, XRCC5, ALAD, ENO3, DRD2, CCNB1, FOSL1, TIMP2, CREB1, JUNB, ITGA2, JUND, CTPS1, IGFBP2, SRD5A1, PAM, MDK, COMT, IL10, GAL, ITGA3, HMGB2, AK4, MAOB, CALR, ABCD3, LOX, HTR2C, PTPRM, TSPO, OXTR, SRD5A2, ACSL1, ABCC1, MCM7, CTNNB1, ADRA1A, PTGS2, SREBF1, SRP14, TGFBR2, PPARG, SNCA, CDKN1A, COL18A1, NNMT, STAT3, ADCYAP1R1, HTR2B, MTHFR, SLC1A3, SLC1A2, GATA4, CDKN1B, UQCRFS1, GCLM, CENPF, STAR, PGF, VEGFB, VEGFC, CPT1A, MAP2K6, FOSB, TERF1, PMS1, OXCT1, HDAC4, PTEN, SRP54, B2M, DAD1, TGFB2, UBE2B, ACTC1, ADAM17, HSD11B2, ABAT, GNAS, SORD, MDM2, HMGCS1, XPC, DHODH, GNA12, RELA, EMX2, RAD51, TJP1, GRIN2A, NFATC2, HDAC1, PTCH1, BLMH, PDE3A, KCNJ11, DPYSL2, DUSP6, HADH, GNAS, AACS, SFRP1, RAD54L, HDAC2, GGH, GATA6, BAD, CPB2, PLIN2, TXN2, SEMA3C, ABCG8, TXNIP, WFDC1, DNMT3B, PPARGC1A, PEMT, VAV3, MYO6, RPH3AL, HDAC5

GO:0042495

BP

detection of triacyl bacterial lipopeptide

The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups.

TLR2, TLR1

GO:0042496

BP

detection of diacyl bacterial lipopeptide

The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups.

TLR2

GO:0042503

BP

tyrosine phosphorylation of Stat3 protein

The process of introducing a phosphate group to a tyrosine residue of a Stat3 protein.

JAK2, LIF

GO:0042506

BP

tyrosine phosphorylation of Stat5 protein

The process of introducing a phosphate group to a tyrosine residue of a Stat5 protein.

JAK2

GO:0042508

BP

tyrosine phosphorylation of Stat1 protein

The process of introducing a phosphate group to a tyrosine residue of a Stat1 protein.

JAK2

GO:0042511

BP

positive regulation of tyrosine phosphorylation of Stat1 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein.

KIT, LIF, IL6ST

GO:0042512

BP

negative regulation of tyrosine phosphorylation of Stat1 protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein.

SOCS3, SOCS1, PTPN2

GO:0042517

BP

positive regulation of tyrosine phosphorylation of Stat3 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein.

SOCS3, JAK2, GH1, IL6, CSF1R, IL6R, KIT, GHR, LIF, IL6ST, STAT3, LEP, HSF1, HDAC1, IL18, HES1, CTF1, HDAC2, CLCF1

GO:0042518

BP

negative regulation of tyrosine phosphorylation of Stat3 protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein.

SOCS3, SOCS1, PPP2R1A, NF2

GO:0042520

BP

positive regulation of tyrosine phosphorylation of Stat4 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein.

IL12A

GO:0042521

BP

negative regulation of tyrosine phosphorylation of Stat4 protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein.

PIBF1

GO:0042523

BP

positive regulation of tyrosine phosphorylation of Stat5 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein.

JAK2, GH1, IGF1, FYN, KIT, GHR, ERBB4

GO:0042524

BP

negative regulation of tyrosine phosphorylation of Stat5 protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein.

PTPN2, NF2, CAV1

GO:0042526

BP

positive regulation of tyrosine phosphorylation of Stat6 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein.

PIBF1

GO:0042527

BP

negative regulation of tyrosine phosphorylation of Stat6 protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein.

PTPN2

GO:0042531

BP

positive regulation of tyrosine phosphorylation of STAT protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.

LYN, CCL5, HCLS1

GO:0042535

BP

positive regulation of tumor necrosis factor biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.

TLR4, HSPB1, CYBB, THBS1, TNFRSF8, MAPKAPK2, TLR1

GO:0042536

BP

negative regulation of tumor necrosis factor biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.

BCL3, IL10, LILRB1, GHSR, GHRL, ERRFI1

GO:0042538

BP

hyperosmotic salinity response

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.

TRPV4

GO:0042541

BP

hemoglobin biosynthetic process

The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.

INHA, INHBA, HIF1A

GO:0042542

BP

response to hydrogen peroxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

KPNA4, LDHA, HP, ADA, COL1A1, CRYAB, JUN, GPX1, HMOX1, PDGFRB, BCL2, HSPD1, EEF2, FOSL1, AREG, SDC1, DUSP1, STAR, PPP2CB, HBB, HBA1, ADAM9, NR4A3, BAD, PDCD10, TXNIP, GLRX2, STK24

GO:0042551

BP

neuron maturation

A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.

KDM1A, CLN5, RB1, NR4A2, CDKN1C

GO:0042552

BP

myelination

The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.

DHH, TSPAN2, TNFRSF21, TGFB1, ERBB2, EGR2, ZNF24, MAL, PMP22, EIF2B5, GPR126, SERINC5, QKI, JAM3, EIF2B4, MYO5A

GO:0042554

BP

superoxide anion generation

The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.

CYBB, EDN1, NCF2, NOX5, NOX4, DUOX1

GO:0042558

BP

pteridine-containing compound metabolic process

The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.

MTR

GO:0042572

BP

retinol metabolic process

The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.

DHRS3, ALDH1A2, ALDH1A1, RBP4, TTR, ADH7, AKR1C3, ALDH1A3, CYP1B1, RDH10, RDH13, RDH11, DGAT2, DHRS9, DHRS4

GO:0042573

BP

retinoic acid metabolic process

The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.

CYP26A1, ALDH1A2, ADH7, ALDH1A3, ALDH8A1, SCPEP1

GO:0042574

BP

retinal metabolic process

The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.

ALDH1A2, AKR1C3, ALDH1A3, AKR1C1, CYP1B1, RDH10, RDH11, ALDH8A1

GO:0042592

BP

homeostatic process

Any biological process involved in the maintenance of an internal steady state.

NR5A2, ANG, MPV17, SMAD1, CREBBP

GO:0042593

BP

glucose homeostasis

Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.

POMC, INS, RBP4, IL6, INSR, GPI, NGFR, NMB, SLC2A4, CYP11B1, PTPN2, HNF1A, CNR1, IGFBP5, AKT1, SSTR5, ADRA1B, PCK1, IRS1, G6PC, PPARG, STAT3, LEP, LEPR, MTNR1B, DHPS, PRKAA2, SESN3, RPS6, PTPN11, SOX4, PTCH1, STK11, ADIPOQ, CRY1, PDK4, HIF1A, ADIPOR2, ERO1B, BAD, ADIPOR1, NR1H4, INPP5K, ASPSCR1, TRPV4, TCF7L2, GPRC5B, MBD5, RPH3AL, STXBP5L

GO:0042594

BP

response to starvation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.

GNPAT, ULK1, GCG, PFKFB1, ZFP36, CAD, ADSL, SSTR1, ADM, DDIT3, HMGCL, PPARG, OXCT1, DHODH, FSTL1, PDK4, AACS, ADSSL1, TBC1D5, PPARGC1A

GO:0042596

BP

fear response

The response of an organism to a perceived external threat.

ADRB1

GO:0042628

BP

mating plug formation

The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males.

SERPINE2

GO:0042631

BP

cellular response to water deprivation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water.

AQP2

GO:0042632

BP

cholesterol homeostasis

Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.

NR5A2, NPC1, LRP5, ABCA1, LDLR, APOA1, APOE, APOA2, APOC3, APOB, FABP3, LPL, FABP4, XBP1, CD24, G6PC, SOAT1, NR1H2, NPC2, CAV1, AKR1C1, MALL, NR1H3, IL18, ACSM3, TMEM97, LDLRAP1, LAMTOR1, APOA5, PCSK9, SCARB1, MYLIP, DGAT2, ABCG8, LIPG

GO:0042633

BP

hair cycle

The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.

KRT16, PTGS2, PPP1R13L

GO:0042634

BP

regulation of hair cycle

Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.

ARNTL, PER1, NIPBL, FA2H

GO:0042637

BP

catagen

The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced.

TGFB2

GO:0042659

BP

regulation of cell fate specification

Any process that mediates the adoption of a specific fate by a cell.

LMO4

GO:0042660

BP

positive regulation of cell fate specification

Any process that activates or enables a cell to adopt a specific fate.

FGF2

GO:0042662

BP

negative regulation of mesodermal cell fate specification

Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.

DKK1, SOX17

GO:0042663

BP

regulation of endodermal cell fate specification

Any process that mediates the specification of a cell into an endoderm cell.

DKK1, DUSP6

GO:0042666

BP

negative regulation of ectodermal cell fate specification

Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell.

FZD7

GO:0042668

BP

auditory receptor cell fate determination

The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed.

HES1

GO:0042692

BP

muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.

BIN1, RORA, HIRA, H3F3A, ANKRD1, SMARCD3, GLMN, QKI, ASF1A

GO:0042693

BP

muscle cell fate commitment

The process in which the cellular identity of muscle cells is acquired and determined.

TBX1

GO:0042698

BP

ovulation cycle

The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.

EGFR, SERPINF1, TYRO3

GO:0042699

BP

follicle-stimulating hormone signaling pathway

The series of molecular signals mediated by follicle-stimulating hormone.

FSHB, FSHR

GO:0042700

BP

luteinizing hormone signaling pathway

The series of molecular signals mediated by luteinizing hormone.

EREG, LHCGR

GO:0042701

BP

progesterone secretion

The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta.

INHBA, FZD4

GO:0042703

BP

menstruation

The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus.

FOXL2

GO:0042704

BP

uterine wall breakdown

The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels.

TGFB2

GO:0042711

BP

maternal behavior

Female behaviors associated with the care and rearing of offspring.

OXTR, GNAQ, PTEN, CREBRF

GO:0042713

BP

sperm ejaculation

The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract.

ACVR2A, OXTR

GO:0042723

BP

thiamine-containing compound metabolic process

The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it.

SLC19A2, TPK1

GO:0042730

BP

fibrinolysis

A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.

F2, PLG, PLAU, PLAT, FGA, FGB, FGG, KRT1, SERPINE1, SERPING1, ANXA2, PLAUR, TMPRSS6, CPB2

GO:0042732

BP

D-xylose metabolic process

The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide.

DCXR

GO:0042733

BP

embryonic digit morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.

LRP5, TULP3, MYCN, GLI2, GLI3, BMP4, GJA1, CTNNB1, BMPR1A, WNT5A, ECE1, GNAQ, GNA12, ZBTB16, SMAD4, HDAC1, TWIST1, TMEM107, OSR1, LMBR1, HDAC2, CREBBP, LNP, IFT122, CHST11, MKS1, ZAK, INTU, B9D1

GO:0042737

BP

drug catabolic process

The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease.

CYP3A4, CYP2D6, CYP2C9, CYP3A5, FMO4

GO:0042738

BP

exogenous drug catabolic process

The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism.

CYP3A4, CYP2A6, CYP2C9, CYP2B6, NUDT15

GO:0042742

BP

defense response to bacterium

Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.

IGLL5, TLR4, TLR3, COCH, HP, PPBP, S100A8, ISG15, MPO, S100A9, MBL2, ANXA3, PRG2, CEBPB, BCL3, IL10, CFP, SYK, SLC11A1, ROMO1, RAB1A, CCL20, CXCL6, HAMP, TMF1, PRKCD, TLR1, MICA, GBP6, MAVS, IFNE, DEFB104A, STAB2, CLEC4D, NR1H4, LYST, STAB1, ADAMTS5

GO:0042743

BP

hydrogen peroxide metabolic process

The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.

EGFR, DUOXA1, DUOXA2

GO:0042744

BP

hydrogen peroxide catabolic process

The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).

MPO, GPX1, GPX3, PRDX6, PRDX2, HBB, HBA1, PRDX1, DUOX2, DUOX1

GO:0042745

BP

circadian sleep/wake cycle

The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.

TH, AHCY

GO:0042747

BP

circadian sleep/wake cycle, REM sleep

A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity.

CST3, SRD5A1, STAR

GO:0042748

BP

circadian sleep/wake cycle, non-REM sleep

All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions.

BTBD9

GO:0042752

BP

regulation of circadian rhythm

Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.

PER1, ROCK2, TOP2A, CREB1, NR1D1, SFPQ, PPP1CC, PPARG, MAPK8, MAPK9, CSNK1D, CSNK1E, PRKAA2, PPP1CA, PPP1CB, PRKDC, ID2, CREM, PPARA, KLF10, NR1H3, HNRNPD, NR1D2, NONO, EZH2, CRY1, CCAR2, PSPC1, PROX1, OPN3, PPARGC1A, NOCT, TIMELESS, BTRC

GO:0042753

BP

positive regulation of circadian rhythm

Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.

ARNTL, RORA, NKX2-1, ARNTL2, BTRC, THRAP3

GO:0042754

BP

negative regulation of circadian rhythm

Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.

SFPQ, CRY1, SUV39H2

GO:0042755

BP

eating behavior

The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.

AGRP, CCK, TH, UCHL1, IAPP, ADRB3, TRH, OXTR, STAT3, OPRL1, LEP, NMU, CPT1A, TCF15, NPY5R, BBS12

GO:0042756

BP

drinking behavior

The specific behavior of an organism relating to the intake of liquids, especially water.

APLN

GO:0042758

BP

long-chain fatty acid catabolic process

The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, a fatty acid with a chain length between C13 and C22.

LIPE

GO:0042759

BP

long-chain fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22.

SCD, PLP1, SCD5, QKI, ELOVL6, MYO5A