GO:0042058

BP

regulation of epidermal growth factor receptor signaling pathway

Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

CDH13, RHBDF1, MVB12A

GO:0042059

BP

negative regulation of epidermal growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

SPRY2, SPRY1, STAM2, AP2A2, EGFR, CLTA, UBC, PTPN2, NUP62, EPS15, AP2S1, CDC42, RPS27A, UBA52, GRB2, AP2B1, PTPRJ, ARHGEF7, STAM, AP2M1, SH3GL2, RNF126

GO:0042060

BP

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

EREG, EGFR, TIMP1, INS, COL3A1, FN1, RAF1, PDGFA, ERBB2, ITGB3, S100A8, DCN, FGF2, SPARC, TPM1, PDGFRB, GLI3, DSP, ALOX15, PDGFRA, SDC1, ERBB3, TNC, LOX, SDC4, TGFBR1, TGFBR2, WNT5A, ELK3, SLC11A1, TGFB2, CCL20, SMAD3, NRG1, PPARD, PPARA, PTK7, ITGA9, C6orf89, SCARB1, DCBLD2, MAP3K5, CORO1B, WNT5B, EPB41L4B, FGFR1OP2, SPRR3, MACF1

GO:0042063

BP

gliogenesis

The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.

ANXA1, CDK6

GO:0042073

BP

intraciliary transport

The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.

SSNA1, BBS12, RPGR, IFT27, IFT46, HSPB11

GO:0042074

BP

cell migration involved in gastrulation

The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).

LRP5, AMOT, SOX17

GO:0042088

BP

T-helper 1 type immune response

An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin.

TLR4, BCL3, IL18

GO:0042089

BP

cytokine biosynthetic process

The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

CD28, PCSK5

GO:0042092

BP

type 2 immune response

An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects.

IL33, IL10, BCL6, IL18

GO:0042093

BP

T-helper cell differentiation

The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell.

PTGER4

GO:0042094

BP

interleukin-2 biosynthetic process

The chemical reactions and pathways resulting in the formation of interleukin-2.

IL18, PAWR, IL1RAP

GO:0042095

BP

interferon-gamma biosynthetic process

The chemical reactions and pathways resulting in the formation of interferon-gamma. Interferon gamma is the only member of the type II interferon found so far.

IL18

GO:0042098

BP

T cell proliferation

The expansion of a T cell population by cell division. Follows T cell activation.

RIPK2, CTPS1, TNFSF4, CCND3, PSMB10, CD151, PIK3CG, RC3H2

GO:0042100

BP

B cell proliferation

The expansion of a B cell population by cell division. Follows B cell activation.

IFNA1 , IFNA16, PTPRC, BCL2, HSPD1, IL7R, CTPS1, IL10, CD40LG, PRKCD, MEF2C, SHB, IFNE

GO:0042102

BP

positive regulation of T cell proliferation

Any process that activates or increases the rate or extent of T cell proliferation.

SASH3, PNP, IL1B, CD4, TFRC, ANXA1, IL6, PTPRC, CD28, CCL5, CD46, CD1D, VCAM1, HLA-DPA1, ZP3, TNFSF4, HLA-DMB, IL12A, CD40LG, CD6, CORO1A, IL6ST, LEP, DHPS, JAK3, PRKCQ, HES1, CD276, VTCN1, TNFSF13B

GO:0042104

BP

positive regulation of activated T cell proliferation

Any process that activates or increases the rate or extent of activated T cell proliferation.

IGF2, IGF1, HMGB1, IGFBP2, TNFSF4, CD24, IL12RB1, STAT5B, FADD, IL18, GPAM, PYCARD

GO:0042108

BP

positive regulation of cytokine biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.

EREG

GO:0042109

BP

lymphotoxin A biosynthetic process

The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A.

BCL10

GO:0042110

BP

T cell activation

The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

PIK3CD, RAB29, ADA, FYN, HSPD1, PRLR, IFNAR1, DPP4, CHRNA7, DDOST, PIK3CG, SMAD3, PPP3CA, DLG1, CASP8, CD276, CLEC7A, FOXP3, AZI2, KIF13B

GO:0042113

BP

B cell activation

The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

PIK3CD, SKAP2, PRKCB, HSPD1, CHRNA7, HDAC4, IGBP1, BST2, CASP8, HDAC9, HDAC5

GO:0042116

BP

macrophage activation

A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

TLR4, EDN2, SLC11A1, SLC7A2, TLR1, JMJD6, CRTC3, FOXP1, CD93

GO:0042117

BP

monocyte activation

The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

ADAM10, MT1G, HYAL2, ADAM9, FOXP1

GO:0042118

BP

endothelial cell activation

The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

TGFBR1, SMAD4, BMPER, APOLD1, P2RX4, FOXP1

GO:0042119

BP

neutrophil activation

The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

CXCL8, CCL5, CXCR2, F2RL1, PRKCD, KMT2E

GO:0042126

BP

nitrate metabolic process

The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid.

MARC1

GO:0042127

BP

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

TNFRSF11B, NR5A2, CHEK1, TNFRSF10C, MAFG, RBFOX2, NUAK1, JAK2, LGR5, TNFRSF21, PLAU, AGT, PPBP, PF4, INHA, JUN, FYN, NGFR, FGR, KIT, ESRRA, JUP, JUNB, JUND, TAL1, CXCL2, TNFRSF1B, SAT1, ERBB3, PTGS1, JAK1, IL4R, FAS, DNMT1, CD27, AGTR1, RPA3, LTBR, TGFBR2, BRCA1, BCL6, CSK, EPS15, ABL2, PTGER2, PLA2G4A, SOX9, PLCD1, BID, JAG1, CXCL6, XIAP, HHEX, PTK2, TNK2, PKD2, BMPR2, EZH2, CCDC88A, STYK1, FA2H, EID2, ARHGEF2, TNFRSF25, SGK3, CIB1, RNF126, GNL3, CDCA7, TXNIP, EGLN3, CHST11, DUSP22, PDS5B, DHCR7, GHRL, CFDP1, TCFL5

GO:0042128

BP

nitrate assimilation

The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances.

SUOX

GO:0042129

BP

regulation of T cell proliferation

Any process that modulates the frequency, rate or extent of T cell proliferation.

RAC2, LGALS3, CTNNB1, SOS1, CD209

GO:0042130

BP

negative regulation of T cell proliferation

Any process that stops, prevents or reduces the rate or extent of T cell proliferation.

TNFRSF21, PDE5A, TGFB1, CEBPB, HLA-G, IL10, DLG1, CD276, LILRB1, GLMN, PELI1, PAWR, NDFIP1, FOXP3, MARCH7, VSIG4, MAD1L1

GO:0042133

BP

neurotransmitter metabolic process

The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.

MAOA, CLN3

GO:0042135

BP

neurotransmitter catabolic process

The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.

MAOA, COMT, MAOB, ABAT

GO:0042136

BP

neurotransmitter biosynthetic process

The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.

TH, ALDH9A1, DAGLB

GO:0042137

BP

sequestering of neurotransmitter

The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system.

SLC18A2

GO:0042138

BP

meiotic DNA double-strand break formation

The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination.

TOP6BL

GO:0042147

BP

retrograde transport, endosome to Golgi

The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

WASH1, GOSR2, RAB29, STX6, SPAG9, VPS26A, CLN5, RHOBTB3, RAB7A, RAB9A, AP1S1, SNX1, DCTN1, VAMP3, DENND5A, ERC1, GBF1, TBC1D5, VPS35, RNF126, RAB6B, BET1L, ANKFY1, VPS29, VTI1B, SNX6, PIKFYVE, SNX5

GO:0042148

BP

strand invasion

The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.

RAD51C, RAD51D, RAD51

GO:0042149

BP

cellular response to glucose starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.

TP53, ASNS, BCL2, HSPA5, SLC2A1, XBP1, ATF4, PRKAA2, PMAIP1, IFI16, UPP1, CPEB4, PIK3C3, PIK3R4, MYBBP1A, IMPACT, SH3GLB1, TBL2

GO:0042157

BP

lipoprotein metabolic process

The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.

ABCA1, APOA1, APOE, APOA2, APOC1, APOC3, ALB, APOB, LPL, BMP1, PRKACA, SDC1, HSPG2, PPARA, APOA5, PCSK9, SCARB1, APOLD1, APOL2

GO:0042158

BP

lipoprotein biosynthetic process

The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.

APOA1, APOE, APOA2, APOB, P4HB

GO:0042159

BP

lipoprotein catabolic process

The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.

LDLR, APOE, APOB

GO:0042167

BP

heme catabolic process

The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

AMBP, HMOX1, BLVRB

GO:0042168

BP

heme metabolic process

The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

BDH2

GO:0042176

BP

regulation of protein catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

XPO1, FURIN, ODC1, CDC42, MDM2, NEDD4L, FAM83D, FAF1

GO:0042177

BP

negative regulation of protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

AZIN1, MDM4, SNX3, EGFR, INS, FYN, SERPINE2, FLNA, PHB, SMAD3, NRG1, RELA, GRIN2A, MAD2L1, SIRT2, BANP, FMN2, SNX12, IRAK3

GO:0042178

BP

xenobiotic catabolic process

The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.

GSTM1, GSTM3, GSTM2, ACSL1, GSTO1, GSTM4, CRYZ

GO:0042180

BP

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

CYP2B6, DHRS4

GO:0042182

BP

ketone catabolic process

The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

OXCT1

GO:0042197

BP

halogenated hydrocarbon metabolic process

The chemical reactions and pathways involving halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. Halogens include fluorine, chlorine, bromine and iodine.

CYP2E1

GO:0042214

BP

terpene metabolic process

The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups.

TH

GO:0042219

BP

cellular modified amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents.

GGACT

GO:0042220

BP

response to cocaine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.

HSP90AA1, HSP90AB1, HSPD1, DRD2, CNR1, SLC6A1, OXTR, HNMT, MDM2, TIAM1, DPYSL2, HDAC2, ADGRL3, DNMT3B, HDAC5

GO:0042226

BP

interleukin-6 biosynthetic process

The chemical reactions and pathways resulting in the formation of interleukin-6.

BCL10

GO:0042231

BP

interleukin-13 biosynthetic process

The chemical reactions and pathways resulting in the formation of interleukin-13.

IL18

GO:0042245

BP

RNA repair

Any process that results in the repair of damaged RNA.

ALKBH1, FTO

GO:0042246

BP

tissue regeneration

The regrowth of lost or destroyed tissues.

APOD, IGFBP1, CCNB1, GAP43, NOTCH1, TM4SF4, APOA5, CPQ

GO:0042253

BP

granulocyte macrophage colony-stimulating factor biosynthetic process

The chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor, cytokines that act in hemopoiesis by controlling the production, differentiation, and function of two related white cell populations, granulocytes and monocytes-macrophages.

IL18

GO:0042254

BP

ribosome biogenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.

GTPBP10, GNL1, RPL34, RPS18, BOP1, ZNF658, MINA, NAF1, MTG1, GNL3, MTG2, DDX31, GNL3L, AATF, RRN3, MRPL36

GO:0042255

BP

ribosome assembly

The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.

NPM1, TSR1, NIP7

GO:0042256

BP

mature ribosome assembly

The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome.

DDX3X, EIF6, C1QBP, SBDS

GO:0042262

BP

DNA protection

Any process in which DNA is protected from damage by, for example, oxidative stress.

CBS, NUDT1, GLRX2, NUDT15

GO:0042267

BP

natural killer cell mediated cytotoxicity

The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.

TUBB, CEBPG, TUBB4B, PRDX1, MICB, MICA, LYST, ULBP3, ULBP2

GO:0042269

BP

regulation of natural killer cell mediated cytotoxicity

Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.

LEP

GO:0042270

BP

protection from natural killer cell mediated cytotoxicity

The process of protecting a cell from natural killer cell mediated cytotoxicity.

HLA-E, SERPINB4, SERPINB9

GO:0042271

BP

susceptibility to natural killer cell mediated cytotoxicity

The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.

PVR, CADM1

GO:0042273

BP

ribosomal large subunit biogenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.

RPL35A, RPL7, RPL5, RPL14, RPL26, RPL11, RRS1, WDR74, MALSU1, EBNA1BP2, WDR12, SDAD1, NIP7, NOC2L

GO:0042274

BP

ribosomal small subunit biogenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.

RPS17, RPS7, RPS16, RPS6, NOM1, EMG1

GO:0042275

BP

error-free postreplication DNA repair

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate.

UBE2V2

GO:0042276

BP

error-prone translesion synthesis

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.

REV3L, UBC, PCNA, RPA3, RFC4, RFC2, RFC5, RFC3, POLE2, RPS27A, UBA52, POLK, POLI

GO:0042278

BP

purine nucleoside metabolic process

The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).

MACROD2, MACROD1

GO:0042297

BP

vocal learning

A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others.

FOXP2, HTT, NRXN1

GO:0042304

BP

regulation of fatty acid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.

PRKAA2, EIF6, PDK4

GO:0042306

BP

regulation of protein import into nucleus

Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.

TGFB1, BMP4, NUP62, NUP58

GO:0042307

BP

positive regulation of protein import into nucleus

Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.

IPO5, ZPR1, TGFB1, GLI3, TPR, JUP, NUTF2, PRKCD, HYAL2, ZIC1, MAPK14, ECT2

GO:0042308

BP

negative regulation of protein import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.

APOD, PKIA, ANGPT1, CHP1, PKIG

GO:0042310

BP

vasoconstriction

A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure.

EDN1, EDN2, EDNRA, HTR7, HTR2B, CAV1, TRPM4

GO:0042311

BP

vasodilation

An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure.

AGT, KNG1, APOE, GPX1, BBS2, MKKS

GO:0042312

BP

regulation of vasodilation

Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels.

ADRB2, ACE, NPPB, AGTR1

GO:0042313

BP

protein kinase C deactivation

Any process resulting in the inhibition or termination of the activity of protein kinase C.

EDN1

GO:0042321

BP

negative regulation of circadian sleep/wake cycle, sleep

Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.

DRD2

GO:0042322

BP

negative regulation of circadian sleep/wake cycle, REM sleep

Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.

GHRL

GO:0042323

BP

negative regulation of circadian sleep/wake cycle, non-REM sleep

Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep.

ADA, ADORA1

GO:0042325

BP

regulation of phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.

SRPX2, CD24, MCM7, PSEN1, RICTOR, SIRT2, PPP1R14C, PPP1R14A, PPP1R14B, BARD1

GO:0042326

BP

negative regulation of phosphorylation

Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.

AHSG, INHA, INHBA, BMP4, CDKN1A, CDKN2B, CDKN2C, CDKN1B, CDKN1C, DYNLL1, GRB10, ANKLE2

GO:0042327

BP

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

SDCBP, EREG, FZD7, BCL10, EGFR, ANG, THBS1, AR, CCL5, MIF, AREG, ITGA6, ILK, ITSN1, KCTD20, PPARGC1B, GLMN, APLN

GO:0042335

BP

cuticle development

The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.

DUOX2, DUOX1

GO:0042340

BP

keratan sulfate catabolic process

The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.

HEXA, GNS, OGN, GALNS, LUM, FMOD, OMD

GO:0042345

BP

regulation of NF-kappaB import into nucleus

Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

NOL3, BCL3, PRDX1

GO:0042346

BP

positive regulation of NF-kappaB import into nucleus

Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

TLR4, TLR3, GREM1, TLR2, TNF, IL1B, PTGS2, RHOA, IL18R1, IL18, SPHK1

GO:0042347

BP

negative regulation of NF-kappaB import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

PPM1B, LITAF, C1QTNF3, CYLD

GO:0042351

BP

de novo' GDP-L-fucose biosynthetic process

The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271).

GMDS

GO:0042355

BP

L-fucose catabolic process

The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose).

FUT1, FUT4, FUT2, FUT8

GO:0042359

BP

vitamin D metabolic process

The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).

CYP27B1, GC, CYP1A1, CYP11A1, CYP3A4, LRP2, CYP2R1

GO:0042369

BP

vitamin D catabolic process

The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).

CYP27B1

GO:0042373

BP

vitamin K metabolic process

The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.

CBR1, VKORC1

GO:0042384

BP

cilium assembly

The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.

BBIP1, EXOC5, ABLIM1, ABCC4, ABLIM3, PCNT, SNAP29, FLNA, RFX2, ACTR2, ATP6V0D1, OCRL, SEPT2, PCM1, FAM161A, FNBP1L, TMEM107, BBS7, AHI1, BBS1, TTC8, POC1B, DYNC2LI1, DNAH5, FBF1, IFT81, RPGR, CLUAP1, TCTN2, IFT74, FOPNL, NEK1, CEP89, BBS2, CCDC113, IFT122, TMEM138, MKKS, IFT46, MKS1, CELSR3, EHD3, CC2D2A, WDR35, ATXN10, RAB23, INTU, CDC14A, B9D1, SSX2IP, KIF3A, CEP83, ATP6V1D

GO:0042391

BP

regulation of membrane potential

Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

WWP2, CACNA1G, DLD, CHRNB1, CNGA1, ACTN2, CHRNA7, GLRB, SLC1A6, SLC26A2, KCNA1, KCNMA1, KCNH2, DLG1, KCNJ11, ASIC2, PXK, SLC26A11, BVES, NEDD4L, SLC26A1, RIMS4, POPDC3, RANGRF, RIMS2

GO:0042403

BP

thyroid hormone metabolic process

The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.

DIO2

GO:0042407

BP

cristae formation

The assembly of cristae, the inwards folds of the inner mitochondrial membrane.

LETM1, UQCC3, APOOL, OMA1, APOO, SAMM50

GO:0042412

BP

taurine biosynthetic process

The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.

CDO1, CSAD

GO:0042415

BP

norepinephrine metabolic process

The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.

PARK2, AKR1B1, EPAS1