GO:0035239

BP

tube morphogenesis

The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.

GATA6

GO:0035249

BP

synaptic transmission, glutamatergic

The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.

PARK2, SLC1A4, CDK5, ALS2

GO:0035261

BP

external genitalia morphogenesis

The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals.

LRP6, NIPBL

GO:0035264

BP

multicellular organism growth

The increase in size or mass of an entire multicellular organism, as opposed to cell growth.

KDM6A, NDUFS6, ERCC1, AR, ERCC2, FGFR2, XPA, G6PC, SLC1A2, GPD2, ATRX, CDKN1C, CDC42, H3F3A, GNAS, APBA1, HHEX, PTPN11, ZFP36L1, SOS1, PDE4D, ARID5B, TMED2, STIL, GNAS, TNS2, PLAG1, ANKRD11, GIGYF2, RBBP6, WDR48, PPP1R13L, CCM2, TBL1XR1, TNKS2, RC3H2, DUOX2, DHCR7, HEG1, KLF2

GO:0035265

BP

organ growth

The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.

BCL2, FGFR2, ADRA1A, PTPN11, ACVR2B, SMAD2, NLGN4X

GO:0035268

BP

protein mannosylation

The addition of a mannose residue to a protein acceptor molecule.

DPM3

GO:0035269

BP

protein O-linked mannosylation

The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.

B4GAT1, LARGE, POMGNT2, SDF2, FKRP, DPM3, POMT1

GO:0035278

BP

miRNA mediated inhibition of translation

The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs

ZFP36, STAT3, EIF6, TNRC6A, RBM4, TNRC6C, AGO4, AGO2, TNRC6B

GO:0035279

BP

mRNA cleavage involved in gene silencing by miRNA

The process in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism.

AGO2

GO:0035280

BP

miRNA loading onto RISC involved in gene silencing by miRNA

The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC).

AGO4, AGO2, DICER1

GO:0035282

BP

segmentation

The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.

ACD

GO:0035284

BP

brain segmentation

Division of the brain into a series of semi-repetitive parts or segments.

HOXA2, EGR2, MAFB

GO:0035295

BP

tube development

The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.

ITGB3, GLI2

GO:0035303

BP

regulation of dephosphorylation

Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule.

SMG5

GO:0035304

BP

regulation of protein dephosphorylation

Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein.

PPP1R14C, PPP1R14A, PPP1R14B

GO:0035305

BP

negative regulation of dephosphorylation

Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule.

IQGAP1, INPP5K

GO:0035306

BP

positive regulation of dephosphorylation

Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule.

IGBP1

GO:0035307

BP

positive regulation of protein dephosphorylation

Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.

TGFB1, ADORA1, CALM2, PRKCD, PPP2R5A, PPP2R4, PPP1R7, CDCA2, NSMF, ANKLE2, CNEP1R1, SPPL3, SYMPK, DLC1, PINK1

GO:0035308

BP

negative regulation of protein dephosphorylation

Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein.

PPP1R15A, YWHAB, IGBP1, PPP2R4

GO:0035313

BP

wound healing, spreading of epidermal cells

The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis.

ITGA5, COL5A1, ADAM17, AJUBA, HBEGF

GO:0035315

BP

hair cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a hair cell.

ERCC2, CTNNB1, PITX2

GO:0035329

BP

hippo signaling

The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.

LATS1, YWHAB, YAP1, YWHAE, TJP1, STK4, TEAD4, TEAD2, AMOT, WWC1, AMOTL1, TEAD3, MOB1A, LATS2, TJP2

GO:0035330

BP

regulation of hippo signaling

Any process that modulates the frequency, rate or extent of hippo signaling.

NF2, NEK8, WWC1

GO:0035331

BP

negative regulation of hippo signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.

WWC2, WWC1, AJUBA, LIMD1, WWC3

GO:0035335

BP

peptidyl-tyrosine dephosphorylation

The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.

PTPDC1, EYA2, CDC14B, DUSP11, EYA4, PTPRC, PTPRF, PTPN2, PTPRB, PTPRD, PTPRG, DUSP1, PTPRM, PTPN4, CDC25A, CDC25B, CDC25C, PTPN9, DUSP3, TPTE, PTEN, DUSP2, PTPN11, PTPRJ, PTP4A2, DUSP8, MTM1, MTMR1, MTMR2, PTPRK, CDKN3, DUSP5, PTPN21, PTPRO, DUSP6, DUSP7, TIMM50, SSH2, DUSP18, SSH3, UBASH3B, DUSP19, PTPMT1, PTP4A1, DUSP9, DUSP26, DUSP23, DUSP16, DUSP21, DUSP22, MTMR4, DUSP13, CDC14A, PTPN22, DUSP10

GO:0035336

BP

long-chain fatty-acyl-CoA metabolic process

The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.

FAR2, DGAT2

GO:0035338

BP

long-chain fatty-acyl-CoA biosynthetic process

The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.

ELOVL7, HACD1, ACOT7, SCD, ACOT8, ACSL4, ACSL1, FASN, PPT1, SLC25A1, HSD17B12, THEM4, HACD2, SCD5, ACOT4, ELOVL1, ELOVL4, ELOVL6, ACOT13, ELOVL5, ACSL6, PPT2, ACOT9

GO:0035349

BP

coenzyme A transmembrane transport

The process in which coenzyme A is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.

SLC25A17

GO:0035350

BP

FAD transmembrane transport

The process in which flavin-adenine dinucleotide (FAD) is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form.

SLC25A17

GO:0035356

BP

cellular triglyceride homeostasis

Any process involved in the maintenance of an internal steady state of triglyceride within a cell or between a cell and its external environment.

XBP1, DGAT2, NR1H4, C1QTNF3

GO:0035357

BP

peroxisome proliferator activated receptor signaling pathway

The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes.

ACTN4, PPARG

GO:0035358

BP

regulation of peroxisome proliferator activated receptor signaling pathway

Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.

ALOX15

GO:0035359

BP

negative regulation of peroxisome proliferator activated receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.

PLIN5, TWIST1

GO:0035360

BP

positive regulation of peroxisome proliferator activated receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.

LEP, PTGIS, ASXL2, CITED2

GO:0035372

BP

protein localization to microtubule

A process in which a protein is transported to, or maintained at, a microtubule.

MID1, GSK3B, MAPRE1, CHAMP1, KIF20B, CRIPT

GO:0035385

BP

Roundabout signaling pathway

A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

SLIT2, RHOA, MYO9B, ROBO3, ROBO2

GO:0035397

BP

helper T cell enhancement of adaptive immune response

Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell.

CD4

GO:0035404

BP

histone-serine phosphorylation

The modification of histones by addition of a phosphate group to a serine residue.

AURKA, PRKAA2

GO:0035407

BP

histone H3-T11 phosphorylation

The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone.

CHEK1, PKN1

GO:0035408

BP

histone H3-T6 phosphorylation

The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone.

PRKCB, PRKCA

GO:0035409

BP

histone H3-Y41 phosphorylation

The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone.

JAK2

GO:0035411

BP

catenin import into nucleus

The directed movement of a catenin protein from the cytoplasm into the nucleus.

AGT, CTNNB1

GO:0035412

BP

regulation of catenin import into nucleus

Any process that modulates the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus.

AXIN1, FZD7, GNAQ, DACT1

GO:0035413

BP

positive regulation of catenin import into nucleus

Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus.

UBR5, EGFR, SMAD3, BAMBI, SEMA5A, KANK1, SULF2, DACT1

GO:0035414

BP

negative regulation of catenin import into nucleus

Any process that decreases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus.

SNAI2, EMD, SFRP5, DACT3

GO:0035418

BP

protein localization to synapse

Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

DLG4, CDK5, ASIC2, NLGN1, PCLO

GO:0035419

BP

activation of MAPK activity involved in innate immune response

Any process that initiates the activity of the inactive enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.

ADAM8

GO:0035425

BP

autocrine signaling

Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type.

SERPINB3, HILPDA

GO:0035426

BP

extracellular matrix-cell signaling

Any process that mediates the transfer of information between the extracellular matrix and a cell.

LRP5, NDP, FZD4

GO:0035434

BP

copper ion transmembrane transport

The directed movement of copper cation across a membrane.

ATOX1, SLC31A1, SLC31A2, SLC11A2

GO:0035435

BP

phosphate ion transmembrane transport

The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore.

SLC37A4, SLC25A3, SLC20A2, SLC20A1, ANKH, ADAMTS8

GO:0035437

BP

maintenance of protein localization in endoplasmic reticulum

Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum.

HSPA5

GO:0035441

BP

cell migration involved in vasculogenesis

The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.

PDGFRB

GO:0035455

BP

response to interferon-alpha

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.

IFITM1, IFNAR2, IFITM3, BST2, LAMP3

GO:0035456

BP

response to interferon-beta

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.

PLSCR1, IFITM1, IFNAR2, IFITM3, BST2, XAF1

GO:0035457

BP

cellular response to interferon-alpha

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.

TPR, IFNAR1, STAR, GAS6

GO:0035458

BP

cellular response to interferon-beta

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.

TLR3, IRF1, CDC34, PNPT1, TRIM6, NDUFA13

GO:0035459

BP

cargo loading into vesicle

The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle.

TMED10, PICALM, TMED2

GO:0035461

BP

vitamin transmembrane transport

The process in which a vitamin is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

ABCC1, SCARB1, SLC23A2

GO:0035469

BP

determination of pancreatic left/right asymmetry

Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism.

NPHP3

GO:0035470

BP

positive regulation of vascular wound healing

Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.

XBP1

GO:0035491

BP

positive regulation of leukotriene production involved in inflammatory response

Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response.

SERPINE1

GO:0035493

BP

SNARE complex assembly

The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.

VAMP4, VAMP7, STX4, VAMP3

GO:0035494

BP

SNARE complex disassembly

The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.

NAPB

GO:0035502

BP

metanephric part of ureteric bud development

The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros.

PKD2

GO:0035505

BP

positive regulation of myosin light chain kinase activity

Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity.

IL1B

GO:0035507

BP

regulation of myosin-light-chain-phosphatase activity

Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity.

PPP1R12A, NUAK1

GO:0035508

BP

positive regulation of myosin-light-chain-phosphatase activity

Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity.

PPP1R12A

GO:0035509

BP

negative regulation of myosin-light-chain-phosphatase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.

ROCK2, TNF

GO:0035511

BP

oxidative DNA demethylation

Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.

TDG

GO:0035518

BP

histone H2A monoubiquitination

The modification of histone H2A by addition of a single ubiquitin group.

TRIM37, SKP1, RING1, CUL4B

GO:0035519

BP

protein K29-linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation.

PARK2, UBE2S, ITCH, UBE2T, UBE2D4

GO:0035520

BP

monoubiquitinated protein deubiquitination

The removal of the ubiquitin group from a monoubiquitinated protein.

USP1, ATXN3, BAP1, USP15

GO:0035522

BP

monoubiquitinated histone H2A deubiquitination

The removal of the ubiquitin group from a monoubiquitinated histone H2A protein.

BAP1

GO:0035523

BP

protein K29-linked deubiquitination

A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein.

ZRANB1

GO:0035524

BP

proline transmembrane transport

The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore.

SLC1A4, SLC36A1

GO:0035526

BP

retrograde transport, plasma membrane to Golgi

The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles.

RAB29, USP6NL

GO:0035542

BP

regulation of SNARE complex assembly

Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.

STXBP1, STXBP6

GO:0035544

BP

negative regulation of SNARE complex assembly

Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.

ANKRD27, TRIM9

GO:0035548

BP

negative regulation of interferon-beta secretion

Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta secretion.

LILRB1

GO:0035552

BP

oxidative single-stranded DNA demethylation

Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.

FTO

GO:0035553

BP

oxidative single-stranded RNA demethylation

Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.

ALKBH5, FTO

GO:0035556

BP

intracellular signal transduction

The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

ASB14, SDCBP, DDX3X, ITGB1BP1, MAST4, DCLK1, FYB, MAPK13, DAPK3, TRAF3IP2, TYROBP, SH3BP5, NUAK1, JAK2, RPS6KA5, STK17B, NFATC1, MAP4K4, HSPB1, GNAI2, PRKCB, FYN, CXCL1, HMOX1, CXCL8, PRKAR1A, BCR, SCG2, PRKAR2A, PRKCSH, HCLS1, CHN1, STMN1, PRKCA, NPR2, RASA1, ZP3, JAK1, IGFBP5, DUSP1, CTGF, PRKAR2B, AKT1, AKT2, ADRA1A, ADRA1B, TGFBR1, ANP32A, PRKCI, CRKL, PSEN1, RGS7, PSEN2, GSK3B, AGTR2, PLCD1, JAK3, DAPK1, PRKAA2, SIK1, RAC3, YWHAE, RAC1, SRPK2, NRG1, GUCY2D, TGFBR3, PRKCQ, ARHGEF5, AKAP13, AKAP6, STK4, SMAD4, SQSTM1, PPP1R1A, DGKZ, ARHGEF7, MELK, PLCL1, PRKD1, STK38, RPS6KA2, RPS6KA1, SMAD2, PKN2, MAPK14, RALGPS1, DGKK, DEPDC1, CDC42BPA, TNS2, MAST2, SPSB3, CSPG4, DNMBP, DEF8, SH3BP5L, NET1, ZBTB33, STK32C, DGKH, TMPRSS6, MAP4K3, ARHGEF28, MINK1, PDZD8, NEK11, INADL, DEPTOR, DLG5, GSG2, DEPDC1B, BLNK, RASSF5, CORO2A, INPP5D, APBB2, ARHGEF2, SGK3, MASTL, ASB16, SRPK1, STAC, MKNK1, PINK1, WNK3, PRKD2, TOLLIP, RACGAP1, SIK2, SDCBP2, WNK1, ASB8, ECT2, MKNK2, CD209, TREM1, PLCB1, ARHGEF4, SH2B1, TULP4, LATS2, NRBP2, PAG1, SPHK1, ZAK, WSB2, PLEK2, FMN2, MARK1, NLK, PRKAG3, DCDC2, AKAP11, TNIK, TLK1, PLA2G4C, PLCL2, SH2B3, AKT3, STK38L, PIKFYVE, CARHSP1, CAB39, MAP4K5, ASB3, CDC42BPB, ARFGEF2, MAP3K4

GO:0035562

BP

negative regulation of chromatin binding

Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

BTAF1, PPP3CA, TDG, NFATC4, WAPL, FBXO18

GO:0035563

BP

positive regulation of chromatin binding

Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

KDM1A, CTBP2, PYGO2, EBF2

GO:0035566

BP

regulation of metanephros size

Any process that modulates the size of a metanephric kidney.

AGTR2

GO:0035567

BP

non-canonical Wnt signaling pathway

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.

FZD6, WNT5A, SFRP5, SFRP4, FZD8

GO:0035574

BP

histone H4-K20 demethylation

The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone.

KDM7A

GO:0035581

BP

sequestering of extracellular ligand from receptor

The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor.

CD46

GO:0035582

BP

sequestering of BMP in extracellular matrix

Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.

FBN1, NBL1

GO:0035583

BP

sequestering of TGFbeta in extracellular matrix

Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins.

FBN1, FBN2, LTBP1

GO:0035584

BP

calcium-mediated signaling using intracellular calcium source

A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response.

PRKACA, VCAM1, PTGFR, BCAP31, CCL20, NTRK2, RYR2

GO:0035585

BP

calcium-mediated signaling using extracellular calcium source

A series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response.

CACNA1C

GO:0035589

BP

G-protein coupled purinergic nucleotide receptor signaling pathway

The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.

PTAFR, P2RY14, P2RY8, GPR34

GO:0035590

BP

purinergic nucleotide receptor signaling pathway

The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity.

ANO6, P2RX4

GO:0035600

BP

tRNA methylthiolation

The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule.

CDKAL1

GO:0035602

BP

fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow

The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow.

FGFR2

GO:0035603

BP

fibroblast growth factor receptor signaling pathway involved in hemopoiesis

The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis.

FGFR2

GO:0035604

BP

fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow

The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow.

FGFR2

GO:0035606

BP

peptidyl-cysteine S-trans-nitrosylation

Transfer of a nitric oxide (NO) group from one cysteine residue to another.

GAPDH, S100A9