GO:0034475

BP

U4 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U4 snRNA molecule.

EXOSC9, EXOSC2, EXOSC7, EXOSC6, EXOSC8, EXOSC4, EXOSC3

GO:0034476

BP

U5 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U5 snRNA molecule.

EXOSC9, EXOSC7, EXOSC8

GO:0034497

BP

protein localization to pre-autophagosomal structure

Any process in which a protein is transported to, or maintained at, the pre-autophagosomal structure (PAS).

MFN2, WIPI1, PIK3C3, WDR45, WIPI2

GO:0034498

BP

early endosome to Golgi transport

The directed movement of substances from early endosomes to the Golgi.

TRAPPC10, SNX1, EHD3

GO:0034501

BP

protein localization to kinetochore

Any process in which a protein is transported to, or maintained at, the kinetochore.

BUB1B, CDK1, CASC5, SPDL1, AURKB, CHAMP1

GO:0034502

BP

protein localization to chromosome

Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.

TEX15

GO:0034504

BP

protein localization to nucleus

A process in which a protein is transported to, or maintained in, a location within the nucleus.

TOR1A, XPO1, PLRG1, DNAJB6, CTDNEP1, COL1A1, LMNA, BMP4, CALR, SOX9, RPL11, MDM2, HHEX, ZBTB16, CNEP1R1, BANP, SYNE2, PIKFYVE

GO:0034505

BP

tooth mineralization

The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum.

COL1A1

GO:0034508

BP

centromere complex assembly

The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere.

CENPV

GO:0034516

BP

response to vitamin B6

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.

KYNU

GO:0034551

BP

mitochondrial respiratory chain complex III assembly

The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane.

UQCRB, TTC19, UQCC3, UQCC2, UQCR10, BCS1L

GO:0034587

BP

piRNA metabolic process

The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.

PIWIL4, TDRD9

GO:0034589

BP

hydroxyproline transport

The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

SLC1A4

GO:0034599

BP

cellular response to oxidative stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

FOXO3, PRKRA, STAU1, PENK, GPX1, PARP1, HSPA1A, HSPA1B, G6PD, ATP2A2, NME2, MT3, PRDX2, SNCA, ETV5, NR4A2, SESN2, FOXO1, HDAC1, NFE2L1, PRKD1, ADNP2, SETX, CPEB2, SIRT2, PNPT1, TXN2, VIMP, PINK1, FANCD2, ATP13A2, SEPN1, PPARGC1A

GO:0034605

BP

cellular response to heat

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

TFEC, PDCD6, IL1A, EIF2S1, LYN, THBS1, HMOX1, HSPA1A, HSPA1B, TPR, HSPA6, CDKN1A, MKI67, IRAK1, ATXN3, HSF1, C11orf73, TRPV1, HDAC2, STAC, TRPV4, SLC52A3, ARPP21

GO:0034612

BP

response to tumor necrosis factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.

ADAM10, MAP2K7, UBD, JAK2, CD14, SELE, PTGS2, CHI3L1, AFF3, IGBP1, ADAM9, RIPK1, CASP8, ADIPOQ, MAP4K3, CXCL16, YTHDC2, NUB1, TNFRSF11A

GO:0034613

BP

cellular protein localization

Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.

RAP2A, DMD, CTNNA1, WNT5A, ID4, CSNK1E, NLRP5, CDC42, ANK2, KCNA1, AMOT, LAMTOR1, NIPBL, AHI1, AJUBA, FRMD6, RRAGC, RRAGD, LATS2, ARMCX3, LAMTOR3, PRPF19, LAMTOR2

GO:0034614

BP

cellular response to reactive oxygen species

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.

FOS, TPM1, PDGFRA, MPV17, AKR1C3, ROMO1, PKD2, PTPRK, PPARGC1B

GO:0034616

BP

response to laminar fluid shear stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls.

SMAD7, SMAD6, ABCA1, TGFB1, ETS1, ADAM9

GO:0034620

BP

cellular response to unfolded protein

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

PARK2, RHBDD1, PACRG

GO:0034625

BP

fatty acid elongation, monounsaturated fatty acid

Elongation of a fatty acid chain into which one C-C double bond has been introduced.

ELOVL7, ELOVL1, ELOVL4, ELOVL6, ELOVL5

GO:0034626

BP

fatty acid elongation, polyunsaturated fatty acid

Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced.

ELOVL7, ELOVL1, ELOVL4, ELOVL6, ELOVL5

GO:0034628

BP

de novo' NAD biosynthetic process from aspartate

The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

NMNAT3

GO:0034629

BP

cellular protein complex localization

A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell.

WASL, SMAD7, SNAPIN, EZR, DLG1, SEH1L

GO:0034633

BP

retinol transport

The directed movement of retinol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A.

RBP4

GO:0034638

BP

phosphatidylcholine catabolic process

The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

ENPP2, PNPLA8

GO:0034644

BP

cellular response to UV

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.

TRIAP1, KDM1A, N4BP1, MYC, TP53, EIF2S1, PCNA, ATF4, YY1, PIK3R1, POLD1, CDC25A, PTGS2, CASP9, FMR1, BAX, EP300, NFATC4, PTPRK, RHBDD1, CREBBP, ERCC4, TP53INP1, AURKB, PBK, USP28, RHNO1, EIF2AK4, RUVBL2, NOC2L

GO:0034645

BP

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

PTH

GO:0034650

BP

cortisol metabolic process

The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.

CYP11A1

GO:0034651

BP

cortisol biosynthetic process

The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.

CYP11B1, CYP11B2

GO:0034653

BP

retinoic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A.

CYP26A1, CYP26B1

GO:0034656

BP

nucleobase-containing small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.

NUDT1, NUDT16, NUDT9, NUDT15, NUDT5

GO:0034670

BP

chemotaxis to arachidonic acid

The directed movement of a motile cell or organism in response to the presence of arachidonic acid.

CREB1

GO:0034695

BP

response to prostaglandin E

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.

GNRH1, TGFBR3

GO:0034696

BP

response to prostaglandin F

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus.

EDN1, YY1

GO:0034698

BP

response to gonadotropin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.

ICAM1, ITGA3

GO:0034699

BP

response to luteinizing hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus.

TGFBR3

GO:0034720

BP

histone H3-K4 demethylation

The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.

KDM1A, KDM5A, KDM5B

GO:0034721

BP

histone H3-K4 demethylation, trimethyl-H3-K4-specific

The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone.

KDM5B

GO:0034755

BP

iron ion transmembrane transport

A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

TTYH1, SLC40A1

GO:0034763

BP

negative regulation of transmembrane transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.

CTTNBP2NL

GO:0034765

BP

regulation of ion transmembrane transport

Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

GPR89A, CLIC1, WWP2, CACNA1G, CLIC3, CYBB, GPR89B, KCNA1, KCNMA1, KCNC3, KCNJ12, SCN9A, CACNA1E, ASIC2, TPCN2, KCNG3, KCNV2, KCNE4, TMEM37, CLIC6, NEDD4L, KCNK17, CACNG6, KCNK12, CLIC5, KCNK6

GO:0034767

BP

positive regulation of ion transmembrane transport

Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

ANO6

GO:0034769

BP

basement membrane disassembly

The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion.

CTSS

GO:0034770

BP

histone H4-K20 methylation

The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone.

WHSC1, KMT5A

GO:0034773

BP

histone H4-K20 trimethylation

The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone.

PWP1, KMT5B, ARID4B, KMT5C

GO:0034776

BP

response to histamine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

DRD2

GO:0034959

BP

endothelin maturation

The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin.

ECE1

GO:0034968

BP

histone lysine methylation

The modification of a histone by addition of one or more methyl groups to a lysine residue.

PRDM2, SETD6, SETD7, EHMT2, WHSC1L1, SMYD3, PRDM6

GO:0034969

BP

histone arginine methylation

The modification of a histone by addition of a methyl group to an arginine residue.

PRMT3

GO:0034970

BP

histone H3-R2 methylation

The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone.

CARM1, PRMT6

GO:0034971

BP

histone H3-R17 methylation

The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone.

CARM1, NR1H4

GO:0034975

BP

protein folding in endoplasmic reticulum

A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).

HSPA5, HSP90B1, CALR, CANX, PDIA3, ERO1B, DNAJC10, EMC1, ERO1A, EMC3

GO:0034976

BP

response to endoplasmic reticulum stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.

BCL2L11, PARK2, ERN1, PPP1R15A, FLOT1, UBE4B, EIF2S1, P4HB, THBS1, CXCL8, EEF2, PDIA4, HSP90B1, ALOX15, ATP2A2, CEBPB, ATF4, PIK3R1, PDIA3, THBS4, DDIT3, UFM1, PPP2CB, EIF2B5, TARDBP, OS9, PDIA5, PDIA6, TMEM259, TXNDC11, DNAJC10, NRBF2, ERO1A, TRIB3, MAP3K5, ERP44, FAM129A, UBA5, TMX4, HYOU1

GO:0034982

BP

mitochondrial protein processing

The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.

OMA1

GO:0034983

BP

peptidyl-lysine deacetylation

The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.

HDAC4, SIRT2, HDAC6, HDAC9

GO:0035019

BP

somatic stem cell population maintenance

Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.

POLR2D, KLF4, LDB2, LRP5, RAF1, FGF2, KIT, SKI, TDGF1, POLR2E, POLR2A, POLR2B, POLR2I, PBX1, STAT3, YAP1, ZFP36L2, SOX9, POLR2J, POLR2K, POLR2G, POLR2L, POU5F1, SOX4, KLF10, SMAD4, CUL4A, HES1, SMAD2, SFRP1, EPAS1, LIN28A, ELF5

GO:0035020

BP

regulation of Rac protein signal transduction

Any process that modulates the frequency, rate or extent of Rac protein signal transduction.

OGT, SSX2IP

GO:0035021

BP

negative regulation of Rac protein signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction.

ARAP3, STMN3

GO:0035022

BP

positive regulation of Rac protein signal transduction

Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction.

KRAS, CAMK2D, ALS2

GO:0035023

BP

regulation of Rho protein signal transduction

Any process that modulates the frequency, rate or extent of Rho protein signal transduction.

ARHGEF10, FLOT1, PLEKHG5, FARP2, RAF1, BCR, VAV1, ARHGDIA, ARHGDIB, SOS1, SOS2, ARHGEF5, ABR, TIAM1, MYO9B, ARHGEF7, ITSN1, ARHGEF16, DNMBP, FGD6, PREX2, NET1, FGD2, MCF2L2, ARHGEF28, ARHGEF39, ARHGEF2, ARHGEF26, FGD4, SPATA13, ALS2, PLEKHG2, ECT2, ARHGEF10L, ARHGEF4, ARHGEF3, ITSN2, VAV3, FARP1

GO:0035024

BP

negative regulation of Rho protein signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.

ARHGAP42, ITGB1, ITGA3, ADRA1A, BCL6, CUL3, KANK1, FLCN, ARAP3, KCTD13, DLC1

GO:0035025

BP

positive regulation of Rho protein signal transduction

Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.

COL3A1, APOA1, PDGFRB, F2R, F2RL1, RAC1, AKAP13, ADGRG1

GO:0035026

BP

leading edge cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet.

JUN, DAB2

GO:0035036

BP

sperm-egg recognition

The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization.

SPAM1

GO:0035048

BP

splicing factor protein import into nucleus

The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane.

TNPO3

GO:0035050

BP

embryonic heart tube development

The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.

CTNNB1, GJA5, HHEX, FOXC1, SOX17, IFT122, NDRG4

GO:0035051

BP

cardiocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.

BMP2

GO:0035054

BP

embryonic heart tube anterior/posterior pattern specification

The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta.

BMP2, GATA4

GO:0035058

BP

nonmotile primary cilium assembly

The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules.

CSNK1D, PCM1, TMEM107, BBS7, BBS1, BBS10, PIBF1, CEP89, BBS2, CENPJ, MKKS, MKS1, CC2D2A, FAM179B

GO:0035063

BP

nuclear speck organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized.

SRPK2

GO:0035065

BP

regulation of histone acetylation

Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein.

FLCN, PYGO2, EID1

GO:0035066

BP

positive regulation of histone acetylation

Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.

SNAI2, TADA2A, RPS6KA5, TGFB1, IL1B, MAPK3, BRCA1, TADA2B, FOXP3, BRD7, PPARGC1A, RUVBL2

GO:0035067

BP

negative regulation of histone acetylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.

SNCA, BRCA1, SET, TWIST1, FOXP3, NOC2L

GO:0035082

BP

axoneme assembly

The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.

TTLL1, RSPH4A, C6orf165, CFAP46, RSPH1, CC2D2A, FAM179B

GO:0035087

BP

siRNA loading onto RISC involved in RNA interference

The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference.

AGO2, DICER1

GO:0035088

BP

establishment or maintenance of apical/basal cell polarity

Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components.

CDC42

GO:0035089

BP

establishment of apical/basal cell polarity

The specification and formation of the polarity of a cell along its apical/basal axis.

PRKCI, FSCN1

GO:0035092

BP

sperm chromatin condensation

The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication.

SRPK1

GO:0035093

BP

spermatogenesis, exchange of chromosomal proteins

The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin.

PSME4

GO:0035094

BP

response to nicotine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.

KCNK1, PENK, EDN1, HMOX1, BCL2, DRD2, CREB1, VCAM1, CNR1, CHRNA7, STAR, ATP1A2, ABAT, LYPD1, HDAC2, SLC7A11

GO:0035095

BP

behavioral response to nicotine

Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.

CHRNB1, CHRNA5, CHRNA7, PPARA

GO:0035105

BP

sterol regulatory element binding protein import into nucleus

The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus, across the nuclear membrane, in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes.

LMNA

GO:0035108

BP

limb morphogenesis

The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping.

GLI3, PTCH1, ZNF141, PCSK5

GO:0035112

BP

genitalia morphogenesis

The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.

CTNNB1

GO:0035115

BP

embryonic forelimb morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.

SHOX2, ALDH1A2, RECK, CTNNB1, WNT3, CACNA1C, RUNX2, TWIST1, NIPBL, RDH10, OSR1, LNP, IFT122, ZNF358

GO:0035116

BP

embryonic hindlimb morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal.

BMP4, CTNNB1, NOTCH1, AFF3, WNT3, GNAS, ZBTB16, TWIST1, GNAS, OSR1, PITX2, CHD7

GO:0035128

BP

post-embryonic forelimb morphogenesis

The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism.

ATRX

GO:0035136

BP

forelimb morphogenesis

The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.

HOXD10, GDF5, ZBTB16, NIPBL, RNF165, SALL3

GO:0035137

BP

hindlimb morphogenesis

The process in which the anatomical structures of the hindlimb are generated and organized.

HOXD10, BMPR1A, GDF5, PTCH1, SALL3

GO:0035148

BP

tube formation

Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.

ITGB1BP1, BCL2L11, VEGFA, NOTCH1, SDCCAG8, ATOH8

GO:0035162

BP

embryonic hemopoiesis

The stages of blood cell formation that take place within the embryo.

KIT, TAL1, KITLG, TGFBR2, PBX1, HIF1A, SH2B3

GO:0035166

BP

post-embryonic hemopoiesis

The stages of blood cell formation that take place after completion of embryonic development.

KLF4, ERCC1, MYO1E

GO:0035176

BP

social behavior

Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.

TBX1, BRINP1, KRAS, TH, OXTR, PTEN, DLG4, MAPK8IP2, EIF4EBP2, NLGN4X, DNAJC9, PTCHD1, MKKS, NRXN1

GO:0035194

BP

posttranscriptional gene silencing by RNA

Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation.

TNRC6A, TNRC6C, AGO4, AGO2, TNRC6B

GO:0035195

BP

gene silencing by miRNA

Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.

CNOT1, EIF6, TNRC6A, AJUBA, TNRC6C, LIMD1, CNOT7, CNOT6

GO:0035196

BP

production of miRNAs involved in gene silencing by miRNA

Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein.

PRKRA, AGO4, AGO2, DICER1

GO:0035229

BP

positive regulation of glutamate-cysteine ligase activity

Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.

GCLM

GO:0035234

BP

ectopic germ cell programmed cell death

Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.

IL1A, IL1B, KIT, KITLG, PRKDC, BAX

GO:0035235

BP

ionotropic glutamate receptor signaling pathway

A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.

APP, GRIA4, GRIN2A, CLN3, CPEB4