GO:0031065

BP

positive regulation of histone deacetylation

Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.

TGFB1, TP53, SREBF1, BCL6, NIPBL, JDP2

GO:0031069

BP

hair follicle morphogenesis

The process in which the anatomical structures of the hair follicle are generated and organized.

BCL2, FGF7, FGFR2, IGFBP5, CTNNB1, NOTCH1, CDC42, TGFB2, KRT17, SOSTDC1, INTU

GO:0031076

BP

embryonic camera-type eye development

The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.

TULP3, ALDH1A2, NES, RDH10, PPP1R13L, PITX2

GO:0031077

BP

post-embryonic camera-type eye development

The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure.

KLF4, VEGFA

GO:0031081

BP

nuclear pore distribution

Any process that establishes the spatial arrangement of nuclear pores within the nuclear envelope.

NDC1

GO:0031086

BP

nuclear-transcribed mRNA catabolic process, deadenylation-independent decay

A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability.

ZFP36, ZFP36L1

GO:0031087

BP

deadenylation-independent decapping of nuclear-transcribed mRNA

Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening.

EDC3, PNRC2

GO:0031098

BP

stress-activated protein kinase signaling cascade

A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.

AKR1B1, MAPKAP1

GO:0031100

BP

animal organ regeneration

The regrowth of a lost or destroyed animal organ.

ANGPT2, APOA1, APOA2, CDK1, GSTP1, IGF2R, CDK4, ANXA3, CCL2, LCP1, HGF, PFKFB1, CCNA2, C5AR1, CAD, ADM, TGFBR2, PPARG, CDKN1A, NNMT, MKI67, NOTCH1, CXCL12, PGF, PRPS1, TGFBR3, PPAT, GAS6, LPIN1, NR0B2, NR4A3, UPF2

GO:0031102

BP

neuron projection regeneration

The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage.

ULK1, APOA1, APOE, PTPRF, ADM, APOA5

GO:0031103

BP

axon regeneration

The regrowth of axons following their loss or damage.

CHL1, JAK2, DHFR, JUN, BCL2, FOLR1, CTNNA1, NREP, RTN4RL1, MTR, JAM3

GO:0031104

BP

dendrite regeneration

The regrowth of dendrites in response to their loss or damage.

MATN2

GO:0031109

BP

microtubule polymerization or depolymerization

Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.

CRYAB

GO:0031110

BP

regulation of microtubule polymerization or depolymerization

Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.

SKA3, SKA2, SKA1, STMN3

GO:0031111

BP

negative regulation of microtubule polymerization or depolymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.

FKBP4

GO:0031113

BP

regulation of microtubule polymerization

Any process that modulates the frequency, rate or extent of microtubule polymerization.

MAPT

GO:0031115

BP

negative regulation of microtubule polymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.

EML2, STMN1, SNCA, FKBP4, MAPRE1, TBCD

GO:0031116

BP

positive regulation of microtubule polymerization

Any process that activates or increases the frequency, rate or extent of microtubule polymerization.

MAPT, CLIP1, RGS2, CDKN1B, PSRC1, SLAIN2, FAM179B

GO:0031117

BP

positive regulation of microtubule depolymerization

Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.

KATNB1, TRPV4, SPAST

GO:0031118

BP

rRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in an rRNA molecule.

DKC1, NOP10, GAR1

GO:0031119

BP

tRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.

RPUSD3, RPUSD4, PUS3

GO:0031120

BP

snRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.

DKC1, NOP10

GO:0031122

BP

cytoplasmic microtubule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.

AXIN1, TUBG1, PCM1, HOOK3, ATAD1, TUBGCP3, CHP1, CIB1, KATNAL1, STMN3, CRIPT, SLAIN2, SPAST

GO:0031123

BP

RNA 3'-end processing

Any process involved in forming the mature 3' end of an RNA molecule.

ZCCHC6, LIN28A

GO:0031124

BP

mRNA 3'-end processing

Any process involved in forming the mature 3' end of an mRNA molecule.

DDX39A, NUDT21, ZC3H11A, PAPOLA, SARNP, SRSF2, SRSF11, SRSF1, NCBP1, CPSF1, CSTF3, SRSF9, SRSF5, SRSF6, RNPS1, THOC7, FIP1L1, PABPN1, ALYREF, SRRM1, THOC2, THOC3, POLDIP3, CPSF2, RBM8A

GO:0031125

BP

rRNA 3'-end processing

Any process involved in forming the mature 3' end of an rRNA molecule.

EXOSC6, EXOSC4

GO:0031128

BP

developmental induction

A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder).

NKX2-1

GO:0031134

BP

sister chromatid biorientation

The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles.

RB1, CHAMP1

GO:0031145

BP

anaphase-promoting complex-dependent catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.

PSMD11, PSMD12, UBE2C, AURKA, PSMD3, BUB3, BUB1B, PSMD10, PTTG1, CDK1, UBC, CCNB1, PSMC3, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, CDC27, PSMC2, PSMB10, PSMC4, PSMB3, PSMD7, UBE2E1, PLK1, PSME3, PSMC1, PSMC6, RPS27A, UBA52, CDC20, PSMD2, MAD2L1, SKP2, PSME4, UBE2S, FBXO31, ANAPC16, AURKB, ANAPC1, CDC23, ANAPC5, ANAPC4, FZR1, ANAPC10

GO:0031146

BP

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.

CCNF, RBX1, SKP1, KIF14, FBXO31, FBXO36, FBXW5, FBXL15, FBXL7, FBXO9, FBXL2, BTRC

GO:0031167

BP

rRNA methylation

The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.

DIMT1

GO:0031175

BP

neuron projection development

The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

TOR1A, PHGDH, PQBP1, ULK1, UBE4B, SNAPIN, APP, IL6, RB1, LAMB1, LYN, HMGB1, MAP2, AREG, STMN1, PTPRM, RAC3, RAB11A, BLOC1S1, BTG2, CDK5, CDK16, CAMSAP2, CNTN1, STX3, CUL4B, ALKBH1, SEPT2, PTPRK, CAMSAP1, FRY, BLOC1S3, CNTN4, NLGN1, UHMK1, DOCK7, PRMT1, STMN3, FLRT3, VAPA, CAMSAP3, ATXN10, BLOC1S6, HDGFRP3

GO:0031214

BP

biomineral tissue development

Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.

ITGB1BP1, SRGN, SPP1, ENPP1, FAM83H, FAM20C, DSPP

GO:0031223

BP

auditory behavior

The behavior of an organism in response to a sound.

DRD2, SLC1A3

GO:0031247

BP

actin rod assembly

The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.

HSP90B1

GO:0031274

BP

positive regulation of pseudopodium assembly

Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.

WASH1, KIT, APC, F2RL1, CDC42, CDC42EP3

GO:0031281

BP

positive regulation of cyclase activity

Any process that activates or increases the activity of a cyclase.

MAPK3, MAPK8, MAPK14

GO:0031284

BP

positive regulation of guanylate cyclase activity

Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.

GUCA1C, ADORA2B, NOS3, GUCA1B

GO:0031290

BP

retinal ganglion cell axon guidance

The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.

NRP1, SLIT2, PTPRM, EPHB2, EFNA5, EPHB1, RPL24, ALCAM, NRCAM, ROBO2

GO:0031291

BP

Ran protein signal transduction

A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state.

KPNB1

GO:0031293

BP

membrane protein intracellular domain proteolysis

The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain.

NGFR, NFKB1, PSEN2, ADAM17, RELA, SPPL2A, RHBDD1, APH1B, APH1A

GO:0031295

BP

T cell costimulation

The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.

PAK3, CD4, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, FYN, LYN, LGALS1, CD28, HLA-DRB4, VAV1, HLA-DPA1, CD24, DPP4, PIK3R1, CD40LG, AKT1, CSK, MAP3K8, PIK3CA, EFNB2, CDC42, GRB2, RAC1, HLA-DRB3, CAV1, PTPN11, PAK2, HLA-DRB5, RICTOR, MAPKAP1, MLST8, TNFSF13B

GO:0031296

BP

B cell costimulation

The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation.

TNFSF13B

GO:0031297

BP

replication fork processing

The process in which a DNA replication fork that has stalled is to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.

EME2, STRA13, PCNA, ATRX, BLM, RAD51, ALYREF, FANCM, APITD1, BOD1L1, FBXO18, EME1, TONSL, PRIMPOL, NUCKS1

GO:0031324

BP

negative regulation of cellular metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

BTN2A2

GO:0031325

BP

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

ACACB, FASN

GO:0031328

BP

positive regulation of cellular biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

CCL5, AJUBA

GO:0031333

BP

negative regulation of protein complex assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.

DDX3X, ULK1, RAF1, GSK3B, CDC42, LMO4, EIF4EBP1, XAF1, SVIP, SOST, IMPACT, LCMT1, DNAJC15

GO:0031334

BP

positive regulation of protein complex assembly

Any process that activates or increases the frequency, rate or extent of protein complex assembly.

TPPP, TGFB1, TNF, FGF2, VEGFA, TAL1, GSK3B, VCP, SPIDR, PPP2R5B, SLF2, FNIP1, AJUBA, SLF1, FNIP2, FAF1

GO:0031338

BP

regulation of vesicle fusion

Any process that modulates the frequency, rate or extent of vesicle fusion.

TBC1D4, TBC1D12, TBC1D8, TBC1D3H, TBC1D8B, RABGAP1L, GRTP1, TBC1D9B, TBC1D3C, TBC1D9, TBC1D3, TBC1D16, TBC1D15, TBC1D5, USP6NL, RUNDC1, EVI5L, TBC1D14, TBC1D2B, RABGAP1

GO:0031339

BP

negative regulation of vesicle fusion

Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion.

TBC1D4, CORO1A

GO:0031340

BP

positive regulation of vesicle fusion

Any process that activates or increases the frequency, rate or extent of vesicle fusion.

ANXA1, ANXA2, SYT1, AKT2, C2CD5

GO:0031344

BP

regulation of cell projection organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.

PIFO

GO:0031345

BP

negative regulation of cell projection organization

Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.

SPRY2, ITGA3

GO:0031346

BP

positive regulation of cell projection organization

Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.

ITGA2, RAB8B

GO:0031365

BP

N-terminal protein amino acid modification

The alteration of the N-terminal amino acid residue in a protein.

METAP2

GO:0031393

BP

negative regulation of prostaglandin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.

PIBF1

GO:0031394

BP

positive regulation of prostaglandin biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.

ANXA1, PTGS2

GO:0031396

BP

regulation of protein ubiquitination

Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein.

WASH1, SIAH2, PARK2, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, TGFBR1, PINK1

GO:0031397

BP

negative regulation of protein ubiquitination

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.

SMAD7, OGT, PRMT3, N4BP1, ISG15, FYN, HSPA1A, HSPA1B, TNFAIP3, TSPO, DNAJA1, GCLC, CDK5, CAV1, SOX4, CRY1, SPOPL, GLMN, RASD2, CHP1, HDAC8, GNL3L, BAG5

GO:0031398

BP

positive regulation of protein ubiquitination

Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.

STRA13, SMAD7, AXIN1, RIPK2, PSMD10, BCL10, ADRB2, HSPA5, AVPR2, BRCA1, PTTG1IP, XIAP, CAV1, BIRC3, ANGPT1, RNF111, TSPYL5, APITD1, COMMD1, RASSF5, PELI1, PRICKLE1, NDFIP1, PINK1, NDFIP2, FANCI, SPHK1, STUB1

GO:0031401

BP

positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

NUPR1, ATG10

GO:0031424

BP

keratinization

The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.

PPL, KRT16, SFN, SPRR2B, CDC42, KRT17, KAZN, SPRR2G, SPRR3

GO:0031427

BP

response to methotrexate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.

DHFR, ASNS

GO:0031440

BP

regulation of mRNA 3'-end processing

Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.

AHCYL1, PAPOLA, ZFP36L1

GO:0031441

BP

negative regulation of mRNA 3'-end processing

Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing.

BARD1

GO:0031442

BP

positive regulation of mRNA 3'-end processing

Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing.

CCNB1, NCBP1

GO:0031444

BP

slow-twitch skeletal muscle fiber contraction

A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.

TNNT1

GO:0031453

BP

positive regulation of heterochromatin assembly

Any process that activates or increases the frequency, rate or extent of heterochromatin formation.

TPR

GO:0031468

BP

nuclear envelope reassembly

The reformation of the nuclear envelope following its breakdown in the context of a normal process.

CHMP2A, CHMP4B, SPAST, NSFL1C

GO:0031497

BP

chromatin assembly

The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus.

TP53, RBBP4, CHAF1A, CHAF1B, NOC2L

GO:0031503

BP

protein complex localization

A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.

BIRC5, FKBP4

GO:0031507

BP

heterochromatin assembly

The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent.

HMGA2

GO:0031508

BP

pericentric heterochromatin assembly

The assembly of chromatin into heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.

H3F3A, CENPV, HELLS

GO:0031509

BP

telomeric heterochromatin assembly

The assembly of chromatin into heterochromatin at the telomere.

H3F3A

GO:0031529

BP

ruffle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.

CSF1R, TPM1, RAC1, LRRC16A, CYFIP1, CORO1B, LIMA1

GO:0031532

BP

actin cytoskeleton reorganization

A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.

FARP2, ANXA1, S100A9, RAP2A, KIT, RALA, EZR, FLNA, S1PR1, FGF7, MYH9, RHOA, CXADR, ATP2C1, EPS8, PTK7, CTTN, CDC42BPA, RICTOR, MINK1, TRPV4, CAPN10, PARVA, TNIK, MKLN1, CDC42BPB

GO:0031536

BP

positive regulation of exit from mitosis

Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).

UBE2C, TGFB1, CDCA5, PHB2

GO:0031547

BP

brain-derived neurotrophic factor receptor signaling pathway

The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands.

BDNF, NTRK2, SLC9A6

GO:0031550

BP

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.

BDNF

GO:0031571

BP

mitotic G1 DNA damage checkpoint

A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage.

TP53, CDK2, FBXO31, RFWD3, GIGYF2, RPS27L

GO:0031572

BP

G2 DNA damage checkpoint

A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage.

CHEK1, CDC14B, BRCA1, BRCC3, MAPKAPK2, PLK1, NEK11, NEK6, DTL, TAOK2, FZR1

GO:0031573

BP

intra-S DNA damage checkpoint

A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.

EME2, MSH2, MRE11A, XPC, MDC1, RAD9B, NEK11, EME1, RAD9A, TIPIN

GO:0031577

BP

spindle checkpoint

A cell cycle checkpoint that originates from the mitotic or meiotic spindle.

SPDL1, AURKB

GO:0031579

BP

membrane raft organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.

NPC1, PPT1, DLG1, MYADM

GO:0031581

BP

hemidesmosome assembly

Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina.

LAMC1, ITGB4, ITGA6, CD151, LAMA3, COL17A1

GO:0031583

BP

phospholipase D-activating G-protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase D (PLD) and a subsequent increase in cellular levels of phosphatidic acid (PA).

EDN1

GO:0031584

BP

activation of phospholipase D activity

Any process that initiates the activity of inactive phospholipase D.

CCL5, ARF4

GO:0031585

BP

regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.

MYO5A

GO:0031587

BP

positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.

HTT, PKD2

GO:0031589

BP

cell-substrate adhesion

The attachment of a cell to the underlying substrate via adhesion molecules.

MYO1G, SMAD6, SORBS3, VWF, ITGB3, ITGB1, ITGAV, ITGA5, ITGA2, ITGA6, CORO1A, PRKX, EPHB1, PPARD, GAS6, ANGPT1, TTYH1

GO:0031622

BP

positive regulation of fever generation

Any process that activates or increases the frequency, rate, or extent of fever generation.

TNF, IL1B, CNR1, PTGS2, PTGER3

GO:0031623

BP

receptor internalization

A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.

RAMP1, RAMP3, TFRC, ITGB2, ITGB1, CXCL8, EZR, CD36, CD9, CXCR2, ADM, ADRBK2, SNCA, SYK, CD81, GRB2, CAV1, PICALM, SNX1, RAB31, LDLRAP1, LILRB1

GO:0031627

BP

telomeric loop formation

The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region.

TERF1

GO:0031629

BP

synaptic vesicle fusion to presynaptic active zone membrane

Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.

SNAP23, STX11, SNAPIN, SNAP29, STX2, SNAP25, STX4, STX3

GO:0031630

BP

regulation of synaptic vesicle fusion to presynaptic membrane

Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.

STXBP1

GO:0031638

BP

zymogen activation

The proteolytic processing of an inactive enzyme to an active form.

CTSH, PRSS3, MMP14, PRSS12

GO:0031639

BP

plasminogen activation

The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.

PLAT, FGA, FGB, FGG, APOH, DHCR24

GO:0031640

BP

killing of cells of other organism

Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.

DEFA4, HAMP

GO:0031641

BP

regulation of myelination

Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.

ZPR1, AKT1, CTNNB1, DLG1, KIF14, TENM4, SIRT2