GO:0032600

BP

chemokine receptor transport out of membrane raft

The directed movement of a chemokine receptor out of a membrane raft.

CD24

GO:0032602

BP

chemokine production

The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

S100A8, S100A9

GO:0032606

BP

type I interferon production

The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

TBK1

GO:0032607

BP

interferon-alpha production

The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

AZI2

GO:0032609

BP

interferon-gamma production

The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.

TLR4, AVPR2, LILRB1, AZI2

GO:0032611

BP

interleukin-1 beta production

The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

IL1B, CASP1, MR1, PYCARD

GO:0032613

BP

interleukin-10 production

The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

TLR2, CD46, PRKCD

GO:0032615

BP

interleukin-12 production

The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

LEP, PRKCD

GO:0032618

BP

interleukin-15 production

The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

TUSC2

GO:0032620

BP

interleukin-17 production

The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

RFTN1, MR1

GO:0032623

BP

interleukin-2 production

The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

SLC11A1

GO:0032632

BP

interleukin-3 production

The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

SLC11A1

GO:0032635

BP

interleukin-6 production

The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

AZI2, ASH1L

GO:0032640

BP

tumor necrosis factor production

The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

AZI2

GO:0032642

BP

regulation of chemokine production

Any process that modulates the frequency, rate, or extent of chemokine production.

SNAI2

GO:0032648

BP

regulation of interferon-beta production

Any process that modulates the frequency, rate, or extent of interferon-beta production.

TRIM38, TIRAP, RNF216

GO:0032649

BP

regulation of interferon-gamma production

Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

ISG15

GO:0032651

BP

regulation of interleukin-1 beta production

Any process that modulates the frequency, rate, or extent of interleukin-1 beta production.

F2R, S1PR3, SPHK1

GO:0032652

BP

regulation of interleukin-1 production

Any process that modulates the frequency, rate, or extent of interleukin-1 production.

ANXA1

GO:0032667

BP

regulation of interleukin-23 production

Any process that modulates the frequency, rate, or extent of interleukin-23 production.

TGFB1

GO:0032674

BP

regulation of interleukin-5 production

Any process that modulates the frequency, rate, or extent of interleukin-5 production.

IL5RA

GO:0032675

BP

regulation of interleukin-6 production

Any process that modulates the frequency, rate, or extent of interleukin-6 production.

MAPKAPK2, AFAP1L2

GO:0032680

BP

regulation of tumor necrosis factor production

Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.

ZFP36, MAPKAPK2, ANGPT1, FOXP1, TBC1D23

GO:0032688

BP

negative regulation of interferon-beta production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production.

PPM1B, RELB, REL, PYCARD

GO:0032689

BP

negative regulation of interferon-gamma production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

TLR4, IL33, PRNP, HMGB1, IL10, TNFSF4, IL1RL1, C1QBP, GAS6, LILRB1, PGLYRP2, FOXP3

GO:0032691

BP

negative regulation of interleukin-1 beta production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.

GSTP1, TNFAIP3, CHRNA7, GHSR, GHRL, ERRFI1

GO:0032692

BP

negative regulation of interleukin-1 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production.

IL10, NR1H4

GO:0032693

BP

negative regulation of interleukin-10 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.

PRG2, JAK3, FOXP3

GO:0032695

BP

negative regulation of interleukin-12 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.

THBS1, IL10, JAK3, C1QBP, PIBF1, IRAK3

GO:0032700

BP

negative regulation of interleukin-17 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.

TLR4, TUSC2, TGFB1, PRNP, TNFSF4, IL12A, FOXP3

GO:0032701

BP

negative regulation of interleukin-18 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production.

IL10

GO:0032703

BP

negative regulation of interleukin-2 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.

PRNP, TNFAIP3, HDAC7, NR1H4, FOXP3, VSIG4

GO:0032707

BP

negative regulation of interleukin-23 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production.

TLR4, RAC1

GO:0032713

BP

negative regulation of interleukin-4 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.

CD83, NDFIP1, FOXP3

GO:0032714

BP

negative regulation of interleukin-5 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.

FOXP3

GO:0032715

BP

negative regulation of interleukin-6 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.

TLR4, SOCS5, TNF, ORM1, HGF, TNFAIP3, IL10, CHRNA7, CSK, GAS6, NR1H4, VIMP, FOXP3, KLF2, IRAK3

GO:0032717

BP

negative regulation of interleukin-8 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production.

IL10, OTUD7B

GO:0032720

BP

negative regulation of tumor necrosis factor production

Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.

TLR4, POMC, ORM1, GSTP1, TNFAIP3, IL10, TSPO, CHRNA7, HSF1, GAS6, GPNMB, TWIST1, ADIPOQ, VIMP, FOXP3, NFKBIL1, PTPN22, IRAK3

GO:0032722

BP

positive regulation of chemokine production

Any process that activates or increases the frequency, rate, or extent of chemokine production.

TLR4, TLR3, RIPK2, TLR2, TNF, IL6, IL6R, ADORA2B, ADAM17, HIF1A

GO:0032725

BP

positive regulation of granulocyte macrophage colony-stimulating factor production

Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.

IL1B, PAEP, IL18

GO:0032727

BP

positive regulation of interferon-alpha production

Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.

TLR4, RIPK2, HSPD1, MAVS, TBK1

GO:0032728

BP

positive regulation of interferon-beta production

Any process that activates or increases the frequency, rate, or extent of interferon-beta production.

TLR4, DDX3X, POLR3G, TLR3, RIPK2, TLR2, FLOT1, IRF1, IFNAR1, HMGB2, MAVS, POLR3C, POLR3F, ZBTB20, POLR3B, TBK1

GO:0032729

BP

positive regulation of interferon-gamma production

Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

TLR4, RIPK2, SASH3, TNF, IL1B, CD14, HSPD1, IFNAR1, HLA-DPA1, BCL3, ZP3, TNFSF4, IL12A, WNT5A, IL12RB1, SLC11A1, PDE4D, FADD, IL18R1, IL18, PYCARD

GO:0032731

BP

positive regulation of interleukin-1 beta production

Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.

JAK2, HSPB1, SMAD3, IFI16

GO:0032732

BP

positive regulation of interleukin-1 production

Any process that activates or increases the frequency, rate, or extent of interleukin-1 production.

TLR4, HDAC1, HDAC2

GO:0032733

BP

positive regulation of interleukin-10 production

Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.

TLR4, TLR2, TUSC2, SASH3, HMGB1, CD28, HSPD1, HGF, CD46, TNFSF4, CD40LG, CD83, PIBF1

GO:0032735

BP

positive regulation of interleukin-12 production

Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.

TLR4, TLR3, RIPK2, TLR2, HMGB1, HSPD1, CD36, HLA-G, TNFSF4, CD40LG, TIRAP, PLCB1

GO:0032736

BP

positive regulation of interleukin-13 production

Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.

IL33, HLA-E, TNFSF4, IL1RAP

GO:0032738

BP

positive regulation of interleukin-15 production

Any process that activates or increases the frequency, rate, or extent of interleukin-15 production.

TIRAP

GO:0032740

BP

positive regulation of interleukin-17 production

Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.

TGFB1, PRKCQ, IL18

GO:0032741

BP

positive regulation of interleukin-18 production

Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.

TLR2

GO:0032743

BP

positive regulation of interleukin-2 production

Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.

MAP3K7, RIPK2, SASH3, ANXA1, TNFSF4, CD83, RUNX1, PDE4D, PRKD2

GO:0032753

BP

positive regulation of interleukin-4 production

Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.

SASH3, IL33, CD28, PRG2, HLA-E, CEBPB, ZP3, TNFSF4, CD40LG, PRKCQ, FOXP3

GO:0032754

BP

positive regulation of interleukin-5 production

Any process that activates or increases the frequency, rate, or extent of interleukin-5 production.

IL33, IL1RL1, PDE4D, IL1RAP

GO:0032755

BP

positive regulation of interleukin-6 production

Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.

TLR4, MAPK13, TLR3, RIPK2, TLR2, IL33, TNF, IL1A, IL1B, IL6, IL6R, HSPD1, CD36, TNFSF4, ADORA2B, WNT5A, ARHGEF2, SPON2, ZBTB20, TBC1D23, PYCARD

GO:0032757

BP

positive regulation of interleukin-8 production

Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.

TLR4, TLR3, TLR5, TLR2, TNF, IL1B, SERPINE1, HSPA1A, HSPA1B, DDIT3, TIRAP, FADD, RIPK1, ADIPOQ, MAVS, AFAP1L2, PRKD2, ZNF580

GO:0032759

BP

positive regulation of TRAIL production

Any process that activates or increases the frequency, rate, or extent of TRAIL production.

HLA-E

GO:0032760

BP

positive regulation of tumor necrosis factor production

Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.

TLR4, TLR3, RIPK2, TLR2, JAK2, SASH3, PF4, CD14, CCL3, CLU, CCL2, HLA-E, CD36, PTAFR, PIK3R1, LEP, TIRAP, FADD, RIPK1, HDAC1, NFATC4, TWIST1, MAVS, HDAC2, ARHGEF2, SPON2, ZBTB20, PYCARD, ARFGEF2

GO:0032762

BP

mast cell cytokine production

Any process that contributes to cytokine production by a mast cell.

KIT

GO:0032764

BP

negative regulation of mast cell cytokine production

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production.

HMOX1, BCL6

GO:0032765

BP

positive regulation of mast cell cytokine production

Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production.

BCL10, NR4A3

GO:0032769

BP

negative regulation of monooxygenase activity

Any process that stops or reduces the activity of a monooxygenase.

SNCA

GO:0032775

BP

DNA methylation on adenine

The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule.

METTL4

GO:0032780

BP

negative regulation of ATPase activity

Any process that stops or reduces the rate of ATP hydrolysis by an ATPase.

TNNI3, PLN, PPIF, CNN3, PXK, PAM16

GO:0032781

BP

positive regulation of ATPase activity

Any process that activates or increases the rate of ATP hydrolysis by an ATPase.

DNAJB6, ATP1B1, PFN1, TPM1, MYL4, DNAJB1, ATP1B3, GABARAPL2, RGN, AHSA2, DNAJC10, DNAJC9, DNAJC1, DNAJC7

GO:0032784

BP

regulation of DNA-templated transcription, elongation

Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.

TCEA3, TSFM, ZNF326, CCAR2

GO:0032785

BP

negative regulation of DNA-templated transcription, elongation

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.

SUPT5H

GO:0032786

BP

positive regulation of DNA-templated transcription, elongation

Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.

SUPT5H, ALYREF, SUPT16H

GO:0032787

BP

monocarboxylic acid metabolic process

The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).

CYP2C9

GO:0032788

BP

saturated monocarboxylic acid metabolic process

The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds.

ACOT4

GO:0032789

BP

unsaturated monocarboxylic acid metabolic process

The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds.

ACOT4

GO:0032790

BP

ribosome disassembly

The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.

DENR, MTIF3, HBS1L

GO:0032792

BP

negative regulation of CREB transcription factor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.

DDIT3, SIK1, FOXP3, EIF2AK4

GO:0032793

BP

positive regulation of CREB transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.

RPS6KA5, VEGFA, EPHA5, PRKD1, CRTC3, CAMK1D, PRKD2

GO:0032796

BP

uropod organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated.

CORO1A, MYH9

GO:0032800

BP

receptor biosynthetic process

The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

TNF, IL10

GO:0032801

BP

receptor catabolic process

The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

TGFB1, CDK5, PIK3R4, SH3GLB1

GO:0032802

BP

low-density lipoprotein particle receptor catabolic process

The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

PCSK9

GO:0032803

BP

regulation of low-density lipoprotein particle receptor catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors.

MYLIP

GO:0032804

BP

negative regulation of low-density lipoprotein particle receptor catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors.

ANXA2, FURIN

GO:0032805

BP

positive regulation of low-density lipoprotein particle receptor catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors.

APOE, PCSK9

GO:0032808

BP

lacrimal gland development

The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye.

FGFR2, SOX9, FOXC1

GO:0032811

BP

negative regulation of epinephrine secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine.

ADRA2B

GO:0032812

BP

positive regulation of epinephrine secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine.

CARTPT

GO:0032814

BP

regulation of natural killer cell activation

Any process that modulates the frequency, rate or extent of natural killer cell activation.

LEP

GO:0032815

BP

negative regulation of natural killer cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation.

MICA, PIBF1

GO:0032816

BP

positive regulation of natural killer cell activation

Any process that activates or increases the frequency, rate or extent of natural killer cell activation.

IL12A, BLOC1S6

GO:0032817

BP

regulation of natural killer cell proliferation

Any process that modulates the frequency, rate or extent of natural killer cell proliferation.

LEP, PTPN22

GO:0032819

BP

positive regulation of natural killer cell proliferation

Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation.

STAT5B, IL18, CD244

GO:0032825

BP

positive regulation of natural killer cell differentiation

Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation.

STAT5B, GAS6

GO:0032827

BP

negative regulation of natural killer cell differentiation involved in immune response

Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response.

PGLYRP2

GO:0032831

BP

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells.

FOXP3

GO:0032835

BP

glomerulus development

The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.

TCF21, BCL2, WT1, PTPRO, HEYL

GO:0032836

BP

glomerular basement membrane development

The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.

NID1, WT1, MPV17, COL4A3, MYO1E, SULF2, SULF1

GO:0032848

BP

negative regulation of cellular pH reduction

Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell.

BCL2

GO:0032849

BP

positive regulation of cellular pH reduction

Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell.

CA2

GO:0032868

BP

response to insulin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.

AGRP, OGT, TLR2, IL6, FABP3, LYN, EGR2, PFKFB1, EGR1, IL10, GAL, PLN, CAD, MC4R, ADM, PCK1, IRS1, LEP, TNFSF10, UCP3, EIF6, SESN2, SESN3, HSD11B2, RELA, PPARA, SRSF6, CRY1, HADH, SLC27A1, EPM2AIP1, GGH, UPRT, CITED1, TRPV4, RETN

GO:0032869

BP

cellular response to insulin stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.

TBC1D4, INSR, APRT, GSTP1, INHBB, PARP1, CCL2, SLC2A4, RHOQ, XBP1, SRD5A1, ENPP1, PIK3R1, AKT1, AKT2, PCK1, IRS1, PPARG, PRKCI, GCLC, STAR, UCP2, VAMP2, PRKDC, GPLD1, PPAT, ZFP36L1, FOXO1, SRSF5, PDE3B, RAB31, LPIN1, ADIPOQ, DENND4C, CPEB2, C2CD5, PCSK9, KAT2B, GHSR, TRIB3, VIMP, INPP5K, SORBS1, CAPN10, ERRFI1, HDAC9, HDAC5, IRS2, MYO5A

GO:0032870

BP

cellular response to hormone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.

SOCS2, SLIT2, FOS, JUN, ASNS, GHR, CYP11B1, JUNB, JUND, IGFBP2, CYP11B2, DUSP1, AVPR2, OXTR, STAT3, PGF, STAT5B, FOSB, UCP3, SIK1, NCOA2, NCOA1, IGFBP7, INPP5K, SIK2, ROBO2

GO:0032872

BP

regulation of stress-activated MAPK cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.

GSTP1, MAPK3, MAPK1, MAP2K2, MAP2K1, PRDX1, NBR1