GO:0021873

BP

forebrain neuroblast division

The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast.

ASPM

GO:0021877

BP

forebrain neuron fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain.

NKX2-1

GO:0021879

BP

forebrain neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.

CSF1R

GO:0021881

BP

Wnt-activated signaling pathway involved in forebrain neuron fate commitment

The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain.

AXIN1

GO:0021882

BP

regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.

DLX2, SMARCC2

GO:0021884

BP

forebrain neuron development

The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.

GNAQ

GO:0021885

BP

forebrain cell migration

The orderly movement of a cell from one site to another at least one of which is located in the forebrain.

EMX2, TYRO3

GO:0021889

BP

olfactory bulb interneuron differentiation

The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb.

ERBB4

GO:0021891

BP

olfactory bulb interneuron development

The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell.

WNT5A, SALL3, ROBO2

GO:0021892

BP

cerebral cortex GABAergic interneuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex.

NKX2-1, ASCL1

GO:0021893

BP

cerebral cortex GABAergic interneuron fate commitment

The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex.

DLX2

GO:0021894

BP

cerebral cortex GABAergic interneuron development

The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell.

RAC3, RAC1

GO:0021895

BP

cerebral cortex neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.

ID4, ZNF335

GO:0021897

BP

forebrain astrocyte development

The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.

KRAS

GO:0021902

BP

commitment of neuronal cell to specific neuron type in forebrain

The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain.

ASCL1

GO:0021903

BP

rostrocaudal neural tube patterning

The process in which the neural tube is divided into specific regions along the rostrocaudal axis.

SOX17

GO:0021904

BP

dorsal/ventral neural tube patterning

The process in which the neural tube is regionalized in the dorsoventral axis.

BMP4, PSEN1

GO:0021914

BP

negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning

Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord.

TULP3, IFT122

GO:0021915

BP

neural tube development

The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.

PHGDH, PLXNA2, ALDH1A2, TGFB1, NOTCH1, PKD1, ZFP36L1, PKD2, ITPK1, STIL, PROX1, SEMA3C, ZNF358, DACT1, INTU

GO:0021930

BP

cerebellar granule cell precursor proliferation

The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.

PSMG1, RORA, RERE

GO:0021935

BP

cerebellar granule cell precursor tangential migration

The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium.

PLXNA2

GO:0021938

BP

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells.

GLI2

GO:0021942

BP

radial glia guided migration of Purkinje cell

The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer.

RBFOX2, DAB1, CTNNA2, RERE

GO:0021943

BP

formation of radial glial scaffolds

The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells.

ITGB1

GO:0021952

BP

central nervous system projection neuron axonogenesis

Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.

DCLK1, EPHB2, NR4A2, EPHB1, SPTBN4

GO:0021953

BP

central nervous system neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.

TULP3

GO:0021954

BP

central nervous system neuron development

The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.

MAP2, LEP, ASCL1, BTG2, CDK5, NTRK2, GBA2

GO:0021955

BP

central nervous system neuron axonogenesis

Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells.

PTEN, PTK2, NDEL1

GO:0021957

BP

corticospinal tract morphogenesis

Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.

FBXO45, EPHA4, CDH11

GO:0021960

BP

anterior commissure morphogenesis

Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum.

NFIB, FBXO45

GO:0021965

BP

spinal cord ventral commissure morphogenesis

The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized.

GLI2

GO:0021972

BP

corticospinal neuron axon guidance through spinal cord

The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues.

SLIT2

GO:0021978

BP

telencephalon regionalization

The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops.

BMP2, BMP4, LHX2

GO:0021983

BP

pituitary gland development

The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.

KDM1A, ALDH1A2, GLI2, BMP4, ETS1, CREB1, SRD5A1, BMPR1A, NKX2-1, NR0B1

GO:0021984

BP

adenohypophysis development

The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.

GHRH, DRD2, HES1

GO:0021986

BP

habenula development

The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland.

NR4A2

GO:0021987

BP

cerebral cortex development

The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.

CCDC85C, FOXP2, WDR62, KDM1A, TACC1, LRP6, TACC2, COL3A1, TH, H2AFX, SRD5A1, CDH2, MDK, GART, LHX2, ASCL1, YWHAE, BAX, KIF14, NCOA1, NTRK2, HIF1A, ASPM, CEP120, MCPH1, BAD, BBS2, MKKS, PLCB1, NDE1, BTBD3, TACC3

GO:0021988

BP

olfactory lobe development

The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell.

SEMA7A

GO:0021997

BP

neural plate axis specification

The pattern specification process in which the axes of the nervous system are established.

PTCH1

GO:0021998

BP

neural plate mediolateral regionalization

The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate.

BMPR1A

GO:0022008

BP

neurogenesis

Generation of cells within the nervous system.

WDR62, ZNF217, CLN5, WNT2, ASCL1, EPHB1, GRIN2A, NOM1, CEP120, PCSK9, BHLHE22, RITA1, CHAC1, SALL3, PRDM6, KIF3A

GO:0022009

BP

central nervous system vasculogenesis

The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.

CTNNB1

GO:0022010

BP

central nervous system myelination

The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.

ID4, PLP1, MYRF

GO:0022011

BP

myelination in peripheral nervous system

The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.

ARHGEF10, SKI, LAMA2, POU3F1, ILK, DAG1, SIRT2, PARD3

GO:0022018

BP

lateral ganglionic eminence cell proliferation

The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population.

GLI3

GO:0022027

BP

interkinetic nuclear migration

The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle.

HHEX, PCM1, HOOK3, CEP120, DOCK7

GO:0022028

BP

tangential migration from the subventricular zone to the olfactory bulb

The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.

OGDH

GO:0022029

BP

telencephalon cell migration

The orderly movement of a cell from one site to another at least one of which is located in the telencephalon.

CXCL12, TNR

GO:0022038

BP

corpus callosum development

The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.

EPHB2, CDK5

GO:0022400

BP

regulation of rhodopsin mediated signaling pathway

Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.

NMT2, GUCA1C, CNGA1, METAP2, CALM2, GUCY2D, GUCA1B

GO:0022406

BP

membrane docking

The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.

CHP1

GO:0022407

BP

regulation of cell-cell adhesion

Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.

EFNA5, ADAM8, MINK1

GO:0022408

BP

negative regulation of cell-cell adhesion

Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.

SPINT2, JAK2, TGFB1, NF2, PTK2, MUC21, TNR

GO:0022409

BP

positive regulation of cell-cell adhesion

Any process that activates or increases the rate or extent of cell adhesion to another cell.

SMAD7, ITGA6, CD47, CITED2

GO:0022414

BP

reproductive process

A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

ANTXR2

GO:0022417

BP

protein maturation by protein folding

The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein.

AIP, CALR, PRDX4, ERO1B, ERO1A

GO:0022601

BP

menstrual cycle phase

The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur.

SFRP1

GO:0022602

BP

ovulation cycle process

A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.

MSTN, PAM, LHCGR, MAP2K6

GO:0022604

BP

regulation of cell morphogenesis

Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.

ZMYM6, SPARC, CFL1, CAPZB, EFNA5, ZMYM3, QRICH1, CAMSAP1, STRIP1, LARP4, ARC, PDZD8, PHIP, FMNL2, AGO4, ZMYM2, ZRANB1

GO:0022605

BP

oogenesis stage

A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell.

RPS6

GO:0022612

BP

gland morphogenesis

The process in which the anatomical structures of a gland are generated and organized.

BCL2, FGFR2, PLAG1

GO:0022614

BP

membrane to membrane docking

The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere.

ICAM1, EZR, VCAM1

GO:0022615

BP

protein to membrane docking

The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere.

SNX3, RAB7A

GO:0022617

BP

extracellular matrix disassembly

A process that results in the breakdown of the extracellular matrix.

SH3PXD2B, WASH1, ADAM10, FLOT1, PLG, A2M, TIMP1, FN1, MMP1, PRSS1, DCN, CTSL, MMP2, MMP10, FURIN, SPP1, LAMC1, BMP1, LCP1, NID1, MMP9, TIMP2, CD44, KLK2, MMP8, MMP11, CTSS, FBN1, FBN2, BSG, CTSK, MMP14, MMP15, MMP16, ADAM8, HSPG2, LAMA3, CTRB2, HTRA1, BCAN, MMP19, ADAMTS5

GO:0022618

BP

ribonucleoprotein complex assembly

The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.

RPL38, SHQ1

GO:0022898

BP

regulation of transmembrane transporter activity

Any process that modulates the frequency, rate or extent of transmembrane transporter activity.

INS, BCL2

GO:0022900

BP

electron transport chain

A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

ETFDH

GO:0022904

BP

respiratory electron transport chain

A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

SDHB, SDHA, ETFDH, NDUFAF2, MYBBP1A, PINK1, PPARGC1A

GO:0023014

BP

signal transduction by protein phosphorylation

A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.

MAP4K4, INSR, LYN, ACVR2A, BMPR1A, ACVR1B, TGFBR1, TGFBR2, NEK4, TGFB2, ACVR1, TYRO3, KCNH2, STK4, PAK2, ACVR2B, BMPR2, AMHR2, NEK1, PAK7, CAB39, STK24

GO:0023016

BP

signal transduction by trans-phosphorylation

A process in which the transfer of one or more phosphate groups by a kinase to a residue in a different protein molecule transmits a signal.

OSR1, WNK1

GO:0023019

BP

signal transduction involved in regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.

PARP1, EPCAM, SMAD3, SMAD2, SOX17

GO:0023021

BP

termination of signal transduction

The signaling process in which signal transduction is brought to an end rather than being reversibly modulated.

PRKCD

GO:0023041

BP

neuronal signal transduction

The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular.

KCNA1, NLGN1, OLFM1

GO:0023052

BP

signaling

The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.

CCL3, TOB2, DLGAP5, DLGAP4

GO:0030001

BP

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

NDFIP1, ARMC1

GO:0030003

BP

cellular cation homeostasis

Any process involved in the maintenance of an internal steady state of cations at the level of a cell.

ATP13A2

GO:0030007

BP

cellular potassium ion homeostasis

Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.

ATP1B1, ATP1A2, ATP12A, ATP1B3, KCNMA1, CAMK2D

GO:0030010

BP

establishment of cell polarity

The specification and formation of anisotropic intracellular organization or cell growth patterns.

WEE1, NEK3, EPHB1, PKD1, PTK2, STK11, RICTOR, RAB11FIP2, SDCCAG8, WWC1, MARK4, JAM3, MARK1

GO:0030011

BP

maintenance of cell polarity

The maintenance of established anisotropic intracellular organization or cell growth patterns.

DST

GO:0030029

BP

actin filament-based process

Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.

SELE

GO:0030030

BP

cell projection organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.

NPHP1, CEP152, AKT1, CUL3, TWF2, POC1A, PIFO, MARK4, DNAH9, WRAP73, DCDC2

GO:0030031

BP

cell projection assembly

Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.

PDGFA, NEFH, RAC2, RAC3

GO:0030032

BP

lamellipodium assembly

Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.

RHOD, ABLIM1, ABLIM3, KIT, S1PR1, CDH13, RAC1, ARHGEF7, PTPRO, CCDC88A, LRRC16A, CYFIP1, AJUBA, SPATA13, NUP85, ARHGEF4, SH2B1, VAV3, WASF2

GO:0030033

BP

microvillus assembly

Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.

RAP2A, EZR, RDX, RAPGEF6, TNIK

GO:0030035

BP

microspike assembly

Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell.

MTSS1, ACTN2, FSCN1

GO:0030036

BP

actin cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

SDCBP, NPHP1, MTSS1, PIP5K1C, DNAJB6, FLNB, ABLIM3, KRAS, PDGFA, PFN1, CXCL1, TMSB15A, BCR, TNXB, CFL1, ITPKA, CORO1A, NF2, BCL6, ABL2, CAPZB, ATXN3, RAC3, CDC42, RHOA, TMSB4X, RAC1, DYNLL1, TMSB10, ARHGEF5, ABR, TRIP10, FSCN1, AMOT, IQSEC1, FGD6, SSH2, RHOU, FGD2, GAS2L3, PHACTR4, PALLD, ELMO1, DOCK2, CORO2A, FGD4, DLC1, CORO1B, INPP5K, RHOJ, PDLIM7, DIAPH3, SDAD1, PLEK2, TAOK2, CORO1C, ARHGAP26, NISCH, DAAM1, WASF2

GO:0030037

BP

actin filament reorganization involved in cell cycle

The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs.

ARAP1

GO:0030041

BP

actin filament polymerization

Assembly of actin filaments by the addition of actin monomers to a filament.

ARHGAP6, JAK2, COBL, ANG, HCLS1, ARPC4, RAC1, CTTN, COBLL1, TTC17

GO:0030042

BP

actin filament depolymerization

Disassembly of actin filaments by the removal of actin monomers from a filament.

MICAL2, CFL1, DSTN, MICAL1

GO:0030047

BP

actin modification

Covalent modification of an actin molecule.

TRIOBP

GO:0030048

BP

actin filament-based movement

Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.

WIPF3, MYH9, ACTC1, MYO1E, MYO9B, MYO6, MYO5A, MYH4, WASF2

GO:0030049

BP

muscle filament sliding

The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.

TPM3, TPM2, VIM, TPM1, DMD, MYL4, TNNT1, MYL6B, DES, TNNI3, TMOD1, ACTN2, MYL6, TPM4, ACTC1, MYBPC1, TTN, MYH2, MYH4

GO:0030050

BP

vesicle transport along actin filament

Movement of a vesicle along an actin filament, mediated by motor proteins.

WASL, ACTN4, FNBP1L, MYRIP, MLPH, MYO5A

GO:0030070

BP

insulin processing

The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges.

CPE, ERO1B

GO:0030071

BP

regulation of mitotic metaphase/anaphase transition

Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.

UBE2C, PLK1, CENPE, CDC6, NEK6, CDC23, ANAPC4, ANAPC10

GO:0030072

BP

peptide hormone secretion

The regulated release of a peptide hormone from a cell.

EDN1

GO:0030073

BP

insulin secretion

The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin.

ANXA1, IL1RN, GAL, MC4R, LEP, ACVR2B, SMAD2, ILDR2, SLC30A8, RAPGEF4, SNX19, RIMS2, MYO5A, PCLO

GO:0030091

BP

protein repair

The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.

TXN, PCMT1, MSRB3

GO:0030097

BP

hemopoiesis

The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.

CSF1R, KIT, TAL1, IL10, ZFP36L2, BRCA2, TGFB2, JAG1, RUNX1, NOTCH2, CD164, ZBTB16, PICALM, CUL4A, RUNX3, RUNX2, CDK13, MELK, EBP, ANGPT1, IFI16, RTKN2, FLCN, MKNK2, ZNF160, ASH2L, L3MBTL1

GO:0030098

BP

lymphocyte differentiation

The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.

IKZF1, CBFB