GO:0021527

BP

spinal cord association neuron differentiation

The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate.

TAL1, ASCL1, LMO4

GO:0021530

BP

spinal cord oligodendrocyte cell fate specification

The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway.

ASCL1

GO:0021532

BP

neural tube patterning

The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.

PTCH1, TMEM107

GO:0021534

BP

cell proliferation in hindbrain

The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain.

C5AR1

GO:0021536

BP

diencephalon development

The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.

SEMA5A

GO:0021537

BP

telencephalon development

The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.

BMP2, BMP4, AVPR2, OXTR, SLC1A2, HES1

GO:0021539

BP

subthalamus development

The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis.

UQCRQ

GO:0021542

BP

dentate gyrus development

The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus.

MDK, PTEN, BTG2, CDK6, EMX2, MEF2C, PROX1

GO:0021544

BP

subpallium development

The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon.

DLX2

GO:0021545

BP

cranial nerve development

The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.

ERBB3, SLC1A3, CHD7

GO:0021547

BP

midbrain-hindbrain boundary initiation

The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.

SSBP3

GO:0021548

BP

pons development

The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.

UQCRQ

GO:0021549

BP

cerebellum development

The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.

FOXP2, GART, SSTR1, ABAT, CNTN1, HNRNPD, NCOA1, NLGN4X, SDF4, PPARGC1A, PTBP2

GO:0021551

BP

central nervous system morphogenesis

The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

ERBB4

GO:0021553

BP

olfactory nerve development

The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.

NTRK1, CHD7

GO:0021554

BP

optic nerve development

The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.

RPL24, NAV2

GO:0021555

BP

midbrain-hindbrain boundary morphogenesis

The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.

HES1

GO:0021557

BP

oculomotor nerve development

The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.

HES1

GO:0021558

BP

trochlear nerve development

The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle.

HES1

GO:0021563

BP

glossopharyngeal nerve development

Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.

NAV2

GO:0021564

BP

vagus nerve development

The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.

NAV2

GO:0021568

BP

rhombomere 2 development

The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.

HOXA2

GO:0021571

BP

rhombomere 5 development

The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.

MAFB

GO:0021572

BP

rhombomere 6 development

The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.

MAFB

GO:0021575

BP

hindbrain morphogenesis

The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.

HES1, DLC1

GO:0021587

BP

cerebellum morphogenesis

The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.

GNPAT, LRP6

GO:0021589

BP

cerebellum structural organization

The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.

DAB1, HSPA5

GO:0021591

BP

ventricular system development

The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.

CENPF, ARMC4, SEMA6D, ANP32B, AK8, MBOAT7

GO:0021599

BP

abducens nerve formation

The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.

HOXA1

GO:0021612

BP

facial nerve structural organization

The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.

NRP1, EGR2, PLXNA3, SEMA3A

GO:0021615

BP

glossopharyngeal nerve morphogenesis

The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.

HOXA3

GO:0021631

BP

optic nerve morphogenesis

The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.

GLI3, EPHB2, EPHB1

GO:0021637

BP

trigeminal nerve structural organization

The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.

NRP1, PLXNA3, SEMA3A

GO:0021644

BP

vagus nerve morphogenesis

The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.

TBX1

GO:0021649

BP

vestibulocochlear nerve structural organization

The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.

NRP1

GO:0021650

BP

vestibulocochlear nerve formation

The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.

ATP8B1

GO:0021658

BP

rhombomere 3 morphogenesis

The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.

HOXA2

GO:0021660

BP

rhombomere 3 formation

The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.

EGR2

GO:0021666

BP

rhombomere 5 formation

The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.

EGR2

GO:0021670

BP

lateral ventricle development

The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle.

NUMB, CDK6, DNAH5, UCHL5

GO:0021675

BP

nerve development

The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.

NRP1, NRP2, ILK, SEMA3A, DICER1

GO:0021680

BP

cerebellar Purkinje cell layer development

The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.

UQCRQ, HSPA5, NAGLU

GO:0021681

BP

cerebellar granular layer development

The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.

MDK

GO:0021682

BP

nerve maturation

A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state.

DAG1

GO:0021683

BP

cerebellar granular layer morphogenesis

The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.

SERPINE2

GO:0021685

BP

cerebellar granular layer structural organization

The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.

KIF14

GO:0021691

BP

cerebellar Purkinje cell layer maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.

ARCN1, RERE

GO:0021693

BP

cerebellar Purkinje cell layer structural organization

The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.

KIF14

GO:0021695

BP

cerebellar cortex development

The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.

AGTR2, OGDH, KIF14, EZH2

GO:0021696

BP

cerebellar cortex morphogenesis

The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.

GLI2

GO:0021697

BP

cerebellar cortex formation

The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.

CDK5, MAP2K1, PTPN11

GO:0021702

BP

cerebellar Purkinje cell differentiation

The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.

RORA, AGTPBP1

GO:0021707

BP

cerebellar granule cell differentiation

The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.

CBLN1, MTPN, KNDC1, PROX1

GO:0021740

BP

principal sensory nucleus of trigeminal nerve development

The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure.

NFIB

GO:0021747

BP

cochlear nucleus development

The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure.

BCL2

GO:0021750

BP

vestibular nucleus development

The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure.

ASCL1

GO:0021756

BP

striatum development

The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.

DRD2, OGDH, SECISBP2, BBS2, MKKS

GO:0021757

BP

caudate nucleus development

The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain.

FOXP2

GO:0021758

BP

putamen development

The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain.

FOXP2

GO:0021759

BP

globus pallidus development

The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain.

NKX2-1

GO:0021762

BP

substantia nigra development

The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).

SYNGR3, RAD1, CNP, HSPA5, G6PD, CKB, COX6B1, ATP5J, MAOB, FGF9, PLP1, ACTB, CDC42, RHOA, CALM2, YWHAE, DYNLL1, YWHAH, CCDC14, SYPL2, POTEE, SIRT2, MAPKAP1, SUDS3, ZNF430, NDRG2, ZNF148

GO:0021763

BP

subthalamic nucleus development

The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function.

PITX2

GO:0021764

BP

amygdala development

The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure.

UBA6

GO:0021766

BP

hippocampus development

The progression of the hippocampus over time from its initial formation until its mature state.

UBA6, UQCRQ, GLI3, ANXA3, NME1, SRD5A1, ATP2B4, SRD5A2, NF2, NKX2-1, ID4, GSK3B, PLXNA3, EPHA5, YWHAE, CDK5, OGDH, DLX2, KCNA1, EIF2B5, KIF14, NCOA1, EZH2, PAPD4, PHLPP2, MFSD2A, NR4A3, EZH1, FGF13, BCAN, BBS2, MKKS, EIF2B3

GO:0021768

BP

nucleus accumbens development

The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia.

ALDH1A3

GO:0021769

BP

orbitofrontal cortex development

The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe.

DRD2, FGFR2

GO:0021772

BP

olfactory bulb development

The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.

CSF1R, SKI, LHX2, ID2, DLX2, SEMA3A, KIF14, EXT1, DPYSL2, CRTAC1, CHD7, AGTPBP1

GO:0021773

BP

striatal medium spiny neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum.

INHBA

GO:0021775

BP

smoothened signaling pathway involved in ventral spinal cord interneuron specification

The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.

GLI2, GLI3, SUFU

GO:0021776

BP

smoothened signaling pathway involved in spinal cord motor neuron cell fate specification

The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.

GLI2, GLI3, SUFU

GO:0021778

BP

oligodendrocyte cell fate specification

The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.

SOX6

GO:0021781

BP

glial cell fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell.

NRG1

GO:0021782

BP

glial cell development

The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

PHGDH, SOX4

GO:0021785

BP

branchiomotor neuron axon guidance

The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.

NRP1, PLXNC1, PLXNA2, PLXNA3, SEMA3A, PLXNA1, PLXND1

GO:0021794

BP

thalamus development

The process in which the thalamus changes over time, from its initial formation to its mature state.

UQCRQ, LRP6, SRD5A1, OGDH, PTCHD1

GO:0021795

BP

cerebral cortex cell migration

The orderly movement of cells from one site to another in the cerebral cortex.

EGFR, NKX2-1, PSEN1, FGF13

GO:0021796

BP

cerebral cortex regionalization

The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops.

TRA2B, EMX2, ADGRG1

GO:0021797

BP

forebrain anterior/posterior pattern specification

The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain.

AXIN1

GO:0021798

BP

forebrain dorsal/ventral pattern formation

The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain.

GLI3, NKX2-1

GO:0021799

BP

cerebral cortex radially oriented cell migration

The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.

FBXO45, RAC1, DIXDC1, NDEL1

GO:0021800

BP

cerebral cortex tangential migration

The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.

FBXO45

GO:0021801

BP

cerebral cortex radial glia guided migration

The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex.

RTN4, ADGRG1

GO:0021812

BP

neuronal-glial interaction involved in cerebral cortex radial glia guided migration

The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.

LAMB1

GO:0021813

BP

cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration

The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex.

DAB1

GO:0021819

BP

layer formation in cerebral cortex

The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.

GLI3, CTNNB1, CDK5, MBOAT7, ADGRG1

GO:0021828

BP

gonadotrophin-releasing hormone neuronal migration to the hypothalamus

The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus.

NRP1, SEMA3A

GO:0021831

BP

embryonic olfactory bulb interneuron precursor migration

The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb.

RAC1

GO:0021836

BP

chemorepulsion involved in postnatal olfactory bulb interneuron migration

The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration.

SLIT2

GO:0021842

BP

chemorepulsion involved in interneuron migration from the subpallium to the cortex

The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex.

NRG1

GO:0021846

BP

cell proliferation in forebrain

The creation of greater cell numbers in the forebrain due to cell division of progenitor cells.

RRM1, EMX2, KIF14

GO:0021847

BP

ventricular zone neuroblast division

The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially.

FGFR1, FGFR2

GO:0021849

BP

neuroblast division in subventricular zone

The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially.

NUMB

GO:0021853

BP

cerebral cortex GABAergic interneuron migration

The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.

DRD2

GO:0021854

BP

hypothalamus development

The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.

UQCRQ, ETS1, SRD5A1, SRD5A2, NR0B1, BAX, RAB3GAP1, NCOA1

GO:0021855

BP

hypothalamus cell migration

The directed movement of a cell into the hypothalamus region of the forebrain.

PITX2

GO:0021860

BP

pyramidal neuron development

The progression of a pyramidal neuron from its initial formation to its mature state.

UQCRQ, FGFR2, PLXNA3, OGDH

GO:0021861

BP

forebrain radial glial cell differentiation

The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.

GLI3, HES1

GO:0021869

BP

forebrain ventricular zone progenitor cell division

The mitotic division of a basal progenitor giving rise to two neurons.

DIXDC1

GO:0021870

BP

Cajal-Retzius cell differentiation

The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene.

PSEN1

GO:0021871

BP

forebrain regionalization

The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops.

PGAP1, WNT2B