GO:0016071

BP

mRNA metabolic process

The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.

CEBPG, PABPC3

GO:0016072

BP

rRNA metabolic process

The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes.

NIFK

GO:0016075

BP

rRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes.

EXOSC6, XRN1, EXOSC4, DIS3

GO:0016077

BP

snoRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins.

NUDT16

GO:0016079

BP

synaptic vesicle exocytosis

Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.

PIP5K1C, SNAPIN, SNAP25, VAMP2, CDK5, CPLX2, TRIM9, PCLO

GO:0016080

BP

synaptic vesicle targeting

The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces.

PSEN1, NLGN1

GO:0016081

BP

synaptic vesicle docking

The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component.

SNAP25, STX3, BLOC1S6

GO:0016082

BP

synaptic vesicle priming

A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.

SNAP23, SYNJ1, SNAP29, SNAP25

GO:0016098

BP

monoterpenoid metabolic process

The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton.

CYP2E1, CYP3A4, CYP2D6, CYP2C9

GO:0016101

BP

diterpenoid metabolic process

The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units.

EGFR, SRD5A1, STAR, PDE3A

GO:0016125

BP

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

CYP17A1, CYP11A1, CYP21A2, FDX1, CYP19A1, CYP11B1, CYP11B2, CYP1B1, CYP51A1, FDX1L, CYP4V2, EBPL, CYP8B1

GO:0016126

BP

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

TM7SF2, CH25H, SQLE, MSMO1

GO:0016137

BP

glycoside metabolic process

The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.

TH

GO:0016139

BP

glycoside catabolic process

The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.

FUCA1, FUCA2, GBA2

GO:0016180

BP

snRNA processing

Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule.

CPSF3L, INTS3, INTS1, INTS4, INTS7, INTS10, INTS6

GO:0016188

BP

synaptic vesicle maturation

Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle.

SNAPIN, STXBP1, DLG4, PICALM

GO:0016189

BP

synaptic vesicle to endosome fusion

Fusion of a synaptic vesicle with an endosome.

EEA1

GO:0016191

BP

synaptic vesicle uncoating

The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane.

SYNJ1

GO:0016192

BP

vesicle-mediated transport

A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

TBC1D4, RAB11FIP3, AP1G2, ZFPL1, KIF20A, SFT2D2, LRPAP1, PRKCI, NSF, TSC2, GDI2, VAMP7, AP1S2, NCALD, RAB11A, RAB1A, VAMP2, AP1B1, GOLGA4, PICALM, RABEP1, SEC23A, TRIP10, VAMP3, ARL17A, AHI1, BVES, RAB2B, SFT2D1, ARAP3, YIPF5, RAB39B, FNBP1, OSBPL1A, SPTBN4, BLZF1, SYTL2, ARFGAP3, FMN2, ADAMTS9, VTI1B, GGA2, GGA1, MYO5B, MAPK8IP3, MAPK8IP1, ERGIC3, GOLT1B, MYO5A

GO:0016197

BP

endosomal transport

The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.

VPS37C, WASH1, DCLK1, AP5Z1, CHMP2A, VPS4B, STAM2, RASSF9, ABCA1, UBC, NSG1, RPS27A, UBA52, BLOC1S1, PICALM, SQSTM1, ZFYVE16, VPS37A, SNX33, STAM, ALS2, SNX18, TINAGL1, AP5M1, CHMP4B, VTA1, SNX9

GO:0016198

BP

axon choice point recognition

The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth.

GAP43

GO:0016199

BP

axon midline choice point recognition

The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.

APP, ROBO3, ROBO2

GO:0016202

BP

regulation of striated muscle tissue development

Any process that modulates the frequency, rate or extent of striated muscle development.

TGFB1, CENPF, MTPN, SMAD3

GO:0016203

BP

muscle attachment

The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).

DMD

GO:0016226

BP

iron-sulfur cluster assembly

The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.

CIAO1, IBA57, ISCA1, FAM96A, NFU1, FAM96B

GO:0016233

BP

telomere capping

A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins.

TERF1, HIST1H4A, PRKDC, ACD, OBFC1, POT1

GO:0016236

BP

macroautophagy

The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded.

PARK2, ATG13, ULK1, ATG12, MFN2, TOMM40, UBC, PRKAG1, PRKAA2, GABARAPL2, RPS27A, UBA52, DYNLL1, CLN3, TCIRG1, SQSTM1, NBR1, RHEB, TOMM20, WIPI1, LAMTOR1, TOMM5, PIK3C3, RB1CC1, OPTN, PIK3R4, MLST8, PINK1, MAP1LC3B, GABARAPL1, ATG10, MAP1LC3A, RRAGC, ZFYVE1, RRAGD, TOMM22, TOMM7, HDAC6, PRKAG3, LAMTOR3, LAMTOR2, WIPI2

GO:0016239

BP

positive regulation of macroautophagy

Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.

SUPT5H, BNIP3L, TRIM13, ULK1, EPM2A, DCN, HMOX1, PRKAA2, SESN2, PAFAH1B2, BNIP3, SQSTM1, HIF1A, RAB12, LARP1, WAC, PINK1, SCOC

GO:0016241

BP

regulation of macroautophagy

Any process that modulates the frequency, rate or extent of macroautophagy.

ATP6V0E1, ATP6V1G1, VPS26A, ERN1, ATP6V1G2, GAPDH, UCHL1, ATP6V1B2, ATP6V1C1, MAPK8, PRKAA2, ATP6V0D1, CDK5, ATP6V1C2, ATP6V0A1, EXOC4, VPS35, ATP13A2, EXOC1, ATP6V1H, SNX6, EXOC7, SH3GLB1, ATP6V1D, SNX5

GO:0016242

BP

negative regulation of macroautophagy

Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.

NPC1, CLN3, PINK1, NRBP2, LZTS1, POLDIP2

GO:0016243

BP

regulation of autophagosome size

Any process that modulates the size of the autophagosome.

ATP13A2

GO:0016254

BP

preassembly of GPI anchor in ER membrane

The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane.

PIGA, PIGF, PIGH, PIGG, PIGW, PIGX, PIGC

GO:0016255

BP

attachment of GPI anchor to protein

A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain.

PLAUR, PGAP1, PIGK, PIGT, PIGU

GO:0016256

BP

N-glycan processing to lysosome

The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome.

GNPTAB, GNPTG

GO:0016259

BP

selenocysteine metabolic process

The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins.

SARS, SEPSECS

GO:0016264

BP

gap junction assembly

Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids.

GJA1, CTNNA1, GJA5, GJC1, PKP2

GO:0016266

BP

O-glycan processing

The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure.

B4GALT5, ST6GAL1, MUC1, MUC5AC, MUC3A, GALNT2, GALNT1, ST3GAL1, ST3GAL3, ST3GAL4, ST3GAL2, MUC21, GALNT5, GALNT7, GALNT10, MUC20, MUC15, GALNT15, GALNT4, XXYLT1, CHST4, B3GNT7, MUCL1, GALNT14, MUC4, B3GNT5, MUC13, ST6GALNAC4, B3GNT2, ST6GALNAC2

GO:0016310

BP

phosphorylation

The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

TK2, PIK3CD, PDXK, FAM20B, PAPSS2, PGK1, TK1, TOP1, PRPS2, CKB, CKMT1A, CKMT2, MAPK3, DCK, EPHB2, AKT1, GK, CHKA, STAT3, HTR2B, PIK3CA, PIK3CB, PIK3CG, SEPHS1, LIMK2, ALDH18A1, PRPS1, CDK5, MVK, TNK2, COASY, PAK2, ITPK1, CERKL, NADK2, DGKK, IDNK, PPIP5K1, GK5, SGMS1, DGKH, SGMS2, DCAKD, RFK, PINK1, PANK2, UCK2, TOLLIP, TPK1, PANK3, UCK1, ETNK1, NMRK1, UCKL1, LIMD1, SHPK, AK3, CHKB, TRRAP

GO:0016311

BP

dephosphorylation

The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.

FBP2, INPP4B, PFKFB2, ALPL, CA3, BPGM, PTPRC, FBP1, ACPP, PFKFB1, PGAM1, NT5E, PTPRB, PON1, DUSP3, PPP1CA, PPP3CA, DUSP8, ITPK1, LPIN1, DUSP5, PFKFB3, PFKFB4, PPIP5K1, NT5DC3, THNSL2, SGPP2, DUSP18, NT5C, PXYLP1, NUDT16, INPP4A, INPP5K, G6PC3, DUSP23, DUSP16, NT5DC2, ACP6, DUSP13, MINPP1, DUSP10

GO:0016320

BP

endoplasmic reticulum membrane fusion

The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.

VCPIP1

GO:0016321

BP

female meiosis chromosome segregation

The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.

MLH1, PLK1

GO:0016322

BP

neuron remodeling

The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.

FARP2, APP, GNAQ, SCARF1, ANKS1A, NTN4

GO:0016331

BP

morphogenesis of embryonic epithelium

The process in which the anatomical structures of embryonic epithelia are generated and organized.

ALDH1A2, FGFR2, VEGFC, GRSF1

GO:0016337

BP

single organismal cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism.

NPHP1, PIP5K1C, MPZL2, SRPX2, CTNND1, LRP6, VNN1, EGFR, CSTA, JUP, CD44, CD58, ITGA6, CD24, COL8A2, CTNNA2, CDH5, CTNNB1, SOX9, PSEN1, JAM2, ADAM8, PKD1, COL14A1, DLG1, RAPGEF1, FAT1, NECTIN1, COL13A1, CBLL1, PDPN, DLG5, FBLIM1, GPR98, NRCAM, CYFIP2, VMP1, PKP4, PKP2, SIGLEC1, TTYH1, C10orf54, VEZT, CD93, NECTIN3, PKP3

GO:0016338

BP

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction.

CLDN4, CLDN3, CLDN1

GO:0016339

BP

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.

CDH2, CDH13, ATP2C1, CDH17, NLGN1, AJUBA, CDH22, PCDHGC3, PCDHB9, PCDHB3, PCDHB14

GO:0016340

BP

calcium-dependent cell-matrix adhesion

The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction.

DAG1, TRPM7

GO:0016344

BP

meiotic chromosome movement towards spindle pole

The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis.

ACTR3, ACTR2

GO:0016358

BP

dendrite development

The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell.

NRP1, DAB1, PAK3, APP, MAP1B, SCARF1, HDAC2, SYNGAP1, FLRT1, GHRL

GO:0016441

BP

posttranscriptional gene silencing

The inactivation of gene expression by a posttranscriptional mechanism.

PUM1

GO:0016446

BP

somatic hypermutation of immunoglobulin genes

Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.

POLQ, UNG, MLH1, MSH2, MSH6, EXO1

GO:0016447

BP

somatic recombination of immunoglobulin gene segments

The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.

UNG, MSH2, MSH6

GO:0016458

BP

gene silencing

Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.

DNMT1, SOX6, SIRT2, KMT2B

GO:0016476

BP

regulation of embryonic cell shape

Any process that modulates the surface configuration of an embryonic cell.

DAG1, SEPT7

GO:0016477

BP

cell migration

The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.

ITGB1BP1, NRDC, JAK2, SDC3, PRPF40A, SORBS2, TGFB1, ANG, ITGB3, ITGB1, FYN, CDK1, ITGAV, THBS1, PDGFRB, FGR, PTPRF, LAMC1, FGFR1, LCP1, JUP, ARF4, SDC1, CDH2, EFNA1, COL5A1, S1PR1, MDK, JAK1, APC, CD24, CTGF, EPHA3, IL12A, SDC4, SDC2, CSK, PRKCI, PIK3CB, ABL2, CD151, GSK3B, JAK3, EMP2, ADAMTS12, PTEN, RHOA, TGFB2, BTG1, RAB1A, TGFBR3, TNK2, FOXC1, TIAM1, BAMBI, PTK7, ADAM9, NFATC2, DGKZ, CUL3, SHROOM2, GAS6, HES1, FAT1, PTPRK, ERBB4, FSCN1, CCDC88A, CDC42BPA, LRRC16A, STYK1, BRAT1, CSPG4, ARC, WWC1, SCYL3, DEPDC1B, PALLD, NANOS1, KCTD13, ELMO1, RHBDF1, CTHRC1, SPATA13, CORO1B, FUT8, NDEL1, FAM83D, PSTPIP2, CD248, NDE1, ABI2, PAK7, ZRANB1, LIMD1, TAOK2, CDC42BPB, GPC6, ADGRG1

GO:0016479

BP

negative regulation of transcription from RNA polymerase I promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter.

FLNA

GO:0016482

BP

cytosolic transport

The directed movement of substances or organelles within the cytosol.

SRSF10, ACTR2

GO:0016485

BP

protein processing

Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.

ADAM10, NRDC, PMPCB, FURIN, GLI3, SRGN, CPM, IDE, CPN1, UQCRC2, CTSS, PCSK1, PCSK6, CASP1, UQCRC1, ECE1, PSEN1, PSEN2, MMP14, METAP2, MMP16, CLN3, PTCH1, PITRM1, CPZ, LONP2, AEBP1, PIK3C3, APH1B, PCSK5, APH1A, FKRP, XPNPEP3

GO:0016486

BP

peptide hormone processing

The generation of a mature peptide hormone by posttranslational processing of a prohormone.

POMC, CGA, FSHB, LHB, SCG5, FURIN, PCSK1, PCSK6, ECE1, PCSK5

GO:0016488

BP

farnesol catabolic process

The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol.

AKR1C3

GO:0016525

BP

negative regulation of angiogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.

KRIT1, SEMA3E, ANGPT2, ROCK2, AGT, APOH, PF4, KLK3, DCN, THBS1, COL4A2, SPARC, CCL2, NPPB, PTPRM, THBS4, TIE1, SERPINF1, SYNJ2BP, GTF2I, FOXO4, COL4A3, TEK, HHEX, FOXC1, PDE3B, AMOT, SULF1, SEMA4A, RGCC, STAB1, GHRL

GO:0016540

BP

protein autoprocessing

Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.

PARP1, FXN, PCSK9

GO:0016553

BP

base conversion or substitution editing

Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s).

APOBEC3G

GO:0016554

BP

cytidine to uridine editing

The conversion of a cytosine residue to uridine in an RNA molecule by deamination.

RBM47

GO:0016557

BP

peroxisome membrane biogenesis

The process in which a peroxisome membrane is synthesized, aggregates, and bonds together.

PEX3

GO:0016558

BP

protein import into peroxisome matrix

The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix.

PEX12, PEX14, LONP2

GO:0016559

BP

peroxisome fission

The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments.

ACOT8, PEX11B, SEC16B, MFF

GO:0016561

BP

protein import into peroxisome matrix, translocation

The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation.

PEX14

GO:0016567

BP

protein ubiquitination

The process in which one or more ubiquitin groups are added to a protein.

UBA6, UBE2QL1, TMEM189, ASB14, NEURL1B, RNF103, WWP2, UBE2C, SOCS2, SOCS3, SOCS6, ENC1, BACH1, MDM4, UBD, BIRC5, SOCS1, MED7, PARK2, SOCS5, FBXO24, MYCBP2, FBXO45, UBA1, AKT1, TRIM23, BRCA1, CCNF, UBA7, CDC34, UBE2E1, PLK1, VCP, CDC42, UBE2D3, UBE2M, DCAF7, RBX1, UBE2B, SKP1, XIAP, MDM2, ZBTB16, RAB40B, TRIM28, OS9, BIRC3, MED21, CUL3, CUL7, TCEB2, UBE2V2, DCAF6, DCAF8, KCTD11, RFWD3, SPSB3, KLHL24, CYHR1, PDZRN4, RNF111, UBR3, CBLL1, SYVN1, CAND1, RNF130, MIB1, UBR1, KLHL7, KBTBD2, TRIM22, HACE1, KLHL36, RNF182, TRIML2, TRIML1, KLHL23, RNF149, RNF169, FBXO18, FBXO30, FBXO25, DCAF11, SH3RF2, DCAF4, TRIM41, MYLIP, KCTD13, MED12, FBXO32, FBXW5, ANAPC16, KLHDC7B, MED30, ITCH, VCPIP1, DCAF5, FEM1C, LRR1, ASB16, KLHL5, UHRF2, NEDD4L, MPHOSPH8, CDCA3, BARD1, FEM1A, TRIM62, PINK1, BACH2, TRIM8, TRIM9, TRIM4, TRIM2, KLHL4, MKRN2, RNF38, WWP1, KCTD10, FBXL15, ASB8, AKTIP, RNF121, MED20, MARCH7, PELI2, TRIM39, TULP4, DCAF13, MED17, RLIM, WSB2, KLHL8, KLHL9, KLHL13, SAE1, RNF14, KLHL3, RABGEF1, FBXL7, FEM1B, FBXO10, FBXO9, FBXL2, STUB1, TRIM33, PDZRN3, BTRC, UBE2D4, ARIH1, ASB3, NUB1

GO:0016569

BP

chromatin modification

The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups.

ARID1A, CHD1, CHD2, DAPK3, SMARCA5, BRD4, H2AFY, NCOR1, CBX7, NR3C1, RB1, BRD2, DNMT1, SMARCA1, RBL1, DEK, ATRX, SMARCA4, HIRA, CBX3, TRIM28, IKZF1, TDG, BRD3, ZMYND11, CHD9, BCORL1, PHF19, SMARCD3, EMSY, PBRM1, BAP18, BANP, RCBTB1, ARID1B, SMARCC2, DPF3, SMARCC1, L3MBTL2, SMARCD1, L3MBTL3, RSF1, ANP32E, TSPYL2, CHD8, HMG20A, ASF1B, H2AFY2, CHD7, LRWD1, TLK1, ASF1A, L3MBTL1, MTF2, SPIN1, CABIN1

GO:0016570

BP

histone modification

The covalent alteration of one or more amino acid residues within a histone protein.

MT3, AURKB, LOXL2

GO:0016571

BP

histone methylation

The modification of histones by addition of methyl groups.

SATB1, SUZ12, CARM1, CTCFL, EHMT2, PRMT6, PRMT1, WHSC1L1

GO:0016572

BP

histone phosphorylation

The modification of histones by addition of phosphate groups.

RPS6KA5, CDK1, CDK2, PRKCD, NEK11, BAZ1B

GO:0016573

BP

histone acetylation

The modification of a histone by the addition of an acetyl group.

MBD3, TAF5, NCOA2, EPC2, TADA2B, KAT6B, CREBBP, KAT6A, GTF3C4, CDYL, TRRAP, NCOA3

GO:0016574

BP

histone ubiquitination

The modification of histones by addition of ubiquitin groups.

SUZ12, HUWE1, UHRF1, USP22

GO:0016575

BP

histone deacetylation

The modification of histones by removal of acetyl groups.

SAP18, KDM1A, TBL1X, SIN3B, MBD3, PHB, HDAC4, RBBP4, MTA1, HDAC1, CHD4, MORF4L2, ARID4B, BRMS1L, SIRT2, HDAC2, HOPX, TBL1XR1, SUDS3, SAP30L, HMG20B, HDAC6, MORF4L1, HDAC9, HDAC5

GO:0016576

BP

histone dephosphorylation

The modification of histones by removal of phosphate groups.

EYA2, EYA4, PPM1F

GO:0016577

BP

histone demethylation

The modification of histones by removal of methyl groups.

KDM4B, ARID5B

GO:0016578

BP

histone deubiquitination

The modification of histones by removal of ubiquitin groups.

USP27X, SUPT3H, TAF10, USP34, USP51, ENY2, USP22, TRRAP

GO:0016579

BP

protein deubiquitination

The removal of one or more ubiquitin groups from a protein.

USP27X, USP12, USP2, USP1, STAMBP, UCHL1, UCHL3, TNFAIP3, USP6, USP11, ATXN3, USP46, DMWD, JOSD1, USP34, USP31, USP53, USP51, USP54, USP45, USP48, USP32, WDR48, WDR20, BAP1, OTUB2, USP28, USP44, USP42, USP36, USP35, USP25, USP22, USP20, USP15, UCHL5

GO:0016584

BP

nucleosome positioning

Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another.

SMARCA5, HIST1H1E, HIST1H1C, RSF1

GO:0016601

BP

Rac protein signal transduction

A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.

FARP2, CDH13, EPS8, TIAM1, RHOU, CYFIP1, HACE1, ELMO1, ALS2, ABI2, HACD3, NISCH, WASF2

GO:0016925

BP

protein sumoylation

The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.

BIRC5, NUPL2, RAD21, MITF, NUP155, TP53, HNRNPC, PARP1, EGR2, TOP1, TOP2A, PCNA, TPR, SP100, NUP62, BRCA1, RANGAP1, NUP153, RANBP2, BLM, SUMO3, NUP107, SUMO2, UBE2I, RAE1, MDM2, XPC, SP3, RING1, NUP160, TRIM28, MTA1, XRCC4, TDG, MDC1, SMC1A, CDCA8, SUMO4, SMC5, EID3, NUP93, NFATC2IP, PHC3, NUP43, NUP37, NUP35, TRPM4, NUP210, HDAC7, NUP205, L3MBTL2, SEH1L, AURKB, SENP5, SMC6, NUP88, NDC1, NUP58, NUP85, SENP6, BCL11A, NSMCE4A, SAE1, NUP50, SMC3, ZNF451

GO:0016926

BP

protein desumoylation

The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.

FAM76B, FAM76A, SENP5, SENP6, SENP3

GO:0016973

BP

poly(A)+ mRNA export from nucleus

The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.

ZC3H11A, HHEX, PABPN1, ZC3H3, NUP93, THOC2, POLDIP3, ENY2, NXF1

GO:0016998

BP

cell wall macromolecule catabolic process

The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall.

LYZL6, LYZ, LYG2

GO:0017015

BP

regulation of transforming growth factor beta receptor signaling pathway

Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.

SMAD7, TGFB1, FOLR1, ITGA3, ZEB1, SMAD3, SMAD4, SMAD2, NREP, EID2, SMURF2, DKK3, TRIM33

GO:0017038

BP

protein import

The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.

APOE, CLU, LAMP2, SNX33

GO:0017055

BP

negative regulation of RNA polymerase II transcriptional preinitiation complex assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.

HMGB1, THRA

GO:0017085

BP

response to insecticide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.

CPOX

GO:0017121

BP

phospholipid scrambling

The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).

PLSCR1, ANO6, PLSCR4

GO:0017143

BP

insecticide metabolic process

The chemical reactions and pathways involving insecticides, chemicals used to kill insects.

CYP1A1, STAR

GO:0017144

BP

drug metabolic process

The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.

CYP1A1, CYP2E1, CYP3A4, CYP2D6, CYP2A6, CYP2C9, CBR1, CYP2B6, CAD, FMO4, FMO2, VKORC1

GO:0017145

BP

stem cell division

The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.

CUL3

GO:0017148

BP

negative regulation of translation

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.

CNOT1, IGF2BP3, DDX3X, ENC1, DAPK3, SYNCRIP, EIF4E2, CNOT3, ANG, GAPDH, EIF4E, EPRS, IGFBP5, CALR, TIA1, RPL13A, FXR1, HRSP12, DAPK1, RACK1, BTG2, PURA, FMR1, ILF3, CIRBP, CAPRIN1, SAMD4B, GIGYF2, CPEB3, NANOS1, RBM4, LIN28A, EIF4ENIF1, SAMD4A, IGF2BP2

GO:0017156

BP

calcium ion regulated exocytosis

The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.

VAMP7, VAMP2, VAMP3, RAPGEF4, CHP1, SDF4, RIMS2

GO:0017157

BP

regulation of exocytosis

Any process that modulates the frequency, rate or extent of exocytosis.

RALA, RAB3B, SYT1, NSF, VAMP2, STX4, STXBP5, CPLX2, RAPGEF4, RAB21, RIMS2, STXBP5L, PCLO

GO:0017158

BP

regulation of calcium ion-dependent exocytosis

Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.

SYT1, SYTL5, SYTL4, TRPV6

GO:0017183

BP

peptidyl-diphthamide biosynthetic process from peptidyl-histidine

The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.

EEF2, DPH3, DPH1, DPH5

GO:0017186

BP

peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase

The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase.

QPCT