|
GO:0010042
|
BP
|
response to manganese ion
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
|
TSPO,
PTGS2,
ADAM9
|
|
GO:0010043
|
BP
|
response to zinc ion
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
|
CA2,
ASS1,
BGLAP,
S100A8,
TH,
ALAD,
VCAM1,
PLN,
PTEN,
HAMP,
SLC30A8,
GGH,
SLC30A1
|
|
GO:0010044
|
BP
|
response to aluminum ion
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus.
|
QDPR,
ALAD,
MAOB
|
|
GO:0010045
|
BP
|
response to nickel cation
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus.
|
CACNA1G
|
|
GO:0010046
|
BP
|
response to mycotoxin
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi.
|
ASS1
|
|
GO:0010106
|
BP
|
cellular response to iron ion starvation
|
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions.
|
HFE
|
|
GO:0010107
|
BP
|
potassium ion import
|
The directed movement of potassium ions into a cell or organelle.
|
ATP1B1,
ATP1A2,
ATP12A,
ATP1B3,
KCNJ12,
KCNJ11
|
|
GO:0010133
|
BP
|
proline catabolic process to glutamate
|
The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate.
|
PRODH
|
|
GO:0010155
|
BP
|
regulation of proton transport
|
Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
NOX5
|
|
GO:0010157
|
BP
|
response to chlorate
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus.
|
PTCH1
|
|
GO:0010159
|
BP
|
specification of organ position
|
The regionalization process in which information that determines the correct position at which organ primordia are formed is generated and perceived resulting in correct positioning of the new organ.
|
HOXA3,
BMP4
|
|
GO:0010164
|
BP
|
response to cesium ion
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus.
|
CYP2R1
|
|
GO:0010165
|
BP
|
response to X-ray
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).
|
ANXA1,
TP53,
ERCC1,
CDKN1A,
MSH2,
BRCC3,
BRCA2,
BLM,
RAD51,
XRCC4,
PMAIP1,
IKBIP
|
|
GO:0010172
|
BP
|
embryonic body morphogenesis
|
The process in which the anatomical structures of the embryonic soma are generated and organized.
|
GREM2,
IFT122
|
|
GO:0010193
|
BP
|
response to ozone
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus.
|
CYP2E1,
EDN1
|
|
GO:0010212
|
BP
|
response to ionizing radiation
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
|
RAD51C,
RAD51D,
RNF8,
ICAM1,
ALAD,
H2AFX,
VCAM1,
RRM1,
BRCA1,
BRCC3,
STAR,
CLK2,
MTA1,
STK11,
INTS3,
RFWD3,
BRAT1,
CYP2R1,
LZIC,
TOPBP1,
RAD54L,
NABP1,
USP28,
DCLRE1C,
NABP2,
INIP,
DNMT3B
|
|
GO:0010216
|
BP
|
maintenance of DNA methylation
|
Any process involved in maintaining the methylation state of a nucleotide sequence.
|
DNMT1,
UHRF2,
UHRF1,
HELLS
|
|
GO:0010224
|
BP
|
response to UV-B
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.
|
BCL2,
IL12A,
MSH2,
XPC,
RELA
|
|
GO:0010225
|
BP
|
response to UV-C
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm.
|
BCL3,
YY1,
BRCA2,
POLH,
MAP3K4
|
|
GO:0010226
|
BP
|
response to lithium ion
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
|
IGFBP2,
PTGS2,
ASCL1,
EIF2B5
|
|
GO:0010232
|
BP
|
vascular transport
|
The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane.
|
GJA1
|
|
GO:0010243
|
BP
|
response to organonitrogen compound
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
|
MGST3,
ABCC4,
CYP2E1,
MGST1,
CDKN1A,
NNMT,
MGST2
|
|
GO:0010248
|
BP
|
establishment or maintenance of transmembrane electrochemical gradient
|
The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore.
|
SLC22A1,
ATP1B1,
ATP1A2,
ATP12A,
ATP1B3,
BAX
|
|
GO:0010256
|
BP
|
endomembrane system organization
|
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
|
ARFGEF2
|
|
GO:0010259
|
BP
|
multicellular organism aging
|
An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).
|
NDUFS6,
EDN1,
TH,
ERCC1,
SLC1A2,
HYAL2,
RNF165,
CISD2,
SEC63
|
|
GO:0010260
|
BP
|
animal organ senescence
|
The process that occurs in an animal organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism.
|
ERO1A
|
|
GO:0010265
|
BP
|
SCF complex assembly
|
The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex.
|
CAND1
|
|
GO:0010266
|
BP
|
response to vitamin B1
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus.
|
ALAD,
TSPO
|
|
GO:0010269
|
BP
|
response to selenium ion
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion.
|
APOB,
RPLP0,
GPX1,
ALAD,
MAOB
|
|
GO:0010273
|
BP
|
detoxification of copper ion
|
Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion.
|
MT1X
|
|
GO:0010288
|
BP
|
response to lead ion
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
|
PTH,
APP,
QDPR,
SPARC,
CDK4,
SLC6A1,
CPOX,
STAR
|
|
GO:0010310
|
BP
|
regulation of hydrogen peroxide metabolic process
|
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide.
|
RAC2,
RAC1,
NOXA1,
PINK1
|
|
GO:0010324
|
BP
|
membrane invagination
|
The infolding of a membrane.
|
CHMP2A,
SNX3,
FCHO2,
FNBP1L
|
|
GO:0010332
|
BP
|
response to gamma radiation
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
|
TRIM13,
MYC,
TP53,
GPX1,
PARP1,
BCL2,
CCL2,
BRCA2,
POLG,
PRKDC,
BAX,
FANCD2
|
|
GO:0010387
|
BP
|
COP9 signalosome assembly
|
The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome.
|
COPS8
|
|
GO:0010388
|
BP
|
cullin deneddylation
|
The modification of cullins by removal of ubiquitin-like protein NEDD8 (RUB1).
|
COPS6,
COPS8,
COPS7B
|
|
GO:0010389
|
BP
|
regulation of G2/M transition of mitotic cell cycle
|
Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.
|
CENPF,
PKIA,
CAMK2D,
KIF14,
RNASEH2B
|
|
GO:0010390
|
BP
|
histone monoubiquitination
|
The modification of histones by addition of a single ubiquitin group.
|
RAG1,
UBE2E1,
UHRF1,
WAC
|
|
GO:0010424
|
BP
|
DNA methylation on cytosine within a CG sequence
|
The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule.
|
DNMT3B
|
|
GO:0010430
|
BP
|
fatty acid omega-oxidation
|
A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation.
|
ADH7,
CYP4V2
|
|
GO:0010447
|
BP
|
response to acidic pH
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
|
CTSS,
SERPINF1,
ASIC2,
ASIC3
|
|
GO:0010452
|
BP
|
histone H3-K36 methylation
|
The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone.
|
WHSC1
|
|
GO:0010453
|
BP
|
regulation of cell fate commitment
|
Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
|
BMP4,
FGFR2
|
|
GO:0010454
|
BP
|
negative regulation of cell fate commitment
|
Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
|
SOSTDC1
|
|
GO:0010457
|
BP
|
centriole-centriole cohesion
|
The process in which the two centrioles within a centrosome remain tightly paired.
|
SGOL1,
CROCC,
CEP135
|
|
GO:0010458
|
BP
|
exit from mitosis
|
The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
|
UBE2C,
CHMP2A,
RPL24,
EPS8,
UBE2S,
CHMP4B,
SPAST
|
|
GO:0010459
|
BP
|
negative regulation of heart rate
|
Any process that stops, prevents or reduces the frequency or rate of heart contraction.
|
PLN,
SRI,
AGTR2,
SPX,
SPTBN4
|
|
GO:0010460
|
BP
|
positive regulation of heart rate
|
Any process that activates or increases the frequency or rate of heart contraction.
|
ADA,
EDN1,
ATP2A2,
EDN2,
ADM,
TRPM4,
RYR2
|
|
GO:0010463
|
BP
|
mesenchymal cell proliferation
|
The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
|
FGF7
|
|
GO:0010464
|
BP
|
regulation of mesenchymal cell proliferation
|
Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
|
ZEB1
|
|
GO:0010466
|
BP
|
negative regulation of peptidase activity
|
Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.
|
SSPO,
PI15,
CST3,
CSTA,
CSTB,
SERPINB3,
SERPINB4,
PI16
|
|
GO:0010467
|
BP
|
gene expression
|
The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
IGF2BP3,
POLR2D,
HNRNPR,
HNRNPC,
HNRNPA1,
GTF2F2,
HNRNPL,
POLR2E,
HNRNPA2B1,
POLR2A,
FAS,
PTBP1,
POLR2B,
HNRNPH1,
GTF2F1,
POLR2I,
RBMX,
HNRNPA3,
HNRNPM,
POLR2J,
POLR2K,
HNRNPH2,
POLR2G,
POLR2L,
HNRNPU,
NCBP1,
HNRNPD,
WTAP,
PCBP1,
METTL14,
NOX4,
IGF2BP2
|
|
GO:0010468
|
BP
|
regulation of gene expression
|
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
DDX39A,
UTY,
PHGDH,
F2,
MYC,
GNRH1,
PTH,
APOE,
IGF1,
ATP1B1,
BCL2,
CDK4,
PTHLH,
PLCG2,
IL10,
G6PC,
AHR,
TGFBR2,
PIK3CA,
ASCL1,
EIF4A1,
PPP2CB,
CDK6,
INSM1,
POU5F1,
APBA1,
ZFP36L1,
ALKBH1,
TOB2,
NPAT,
SART3,
ASIC2,
HIF1A,
PHLDA2,
STXBP5,
RICTOR,
MSANTD1,
DDX46,
STAB2,
PROX1,
FAM46A,
FUT8,
MAPK8IP3,
KIAA0430,
MAP3K4
|
|
GO:0010469
|
BP
|
regulation of receptor activity
|
Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.
|
PLAU,
SERPINE1,
PRKCD,
PDE4D,
MAPK8IP2,
PPP2R5B,
PCSK9,
HDAC6
|
|
GO:0010470
|
BP
|
regulation of gastrulation
|
Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.
|
DAG1,
PHLDB2,
PHLDB1
|
|
GO:0010477
|
BP
|
response to sulfur dioxide
|
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus.
|
ICAM1
|
|
GO:0010482
|
BP
|
regulation of epidermal cell division
|
Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis.
|
SFN
|
|
GO:0010498
|
BP
|
proteasomal protein catabolic process
|
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
|
SOCS6,
PARK2,
NR1D1,
AGXT,
PMAIP1,
PRPF19
|
|
GO:0010499
|
BP
|
proteasomal ubiquitin-independent protein catabolic process
|
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin.
|
ENC1,
PSME4
|
|
GO:0010501
|
BP
|
RNA secondary structure unwinding
|
The process in which a secondary structure of RNA are broken or 'melted'.
|
DDX39A,
DDX3X,
DDX5,
EIF4A1,
EIF4A2,
DDX46,
DDX54,
DDX17,
DDX27,
DDX23,
DDX24,
DDX47,
DHX36,
DDX31,
AGO4,
DDX28,
DDX43,
DDX20,
AGO2,
DDX52,
DDX49
|
|
GO:0010506
|
BP
|
regulation of autophagy
|
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
DAPK3,
PARK2,
ULK1,
HSPB1,
PSAP,
HMGB1,
MAPT,
XBP1,
CASP1,
ABL2,
DAPK1,
PIP4K2B,
EP300,
ITPR1,
IFI16,
DRAM2,
CISD2,
DRAM1,
TPCN2,
USP13,
NRBF2,
VMP1,
RRAGC,
RRAGD,
HDAC6,
FBXL2,
PYCARD,
BOK,
LAMP3
|
|
GO:0010507
|
BP
|
negative regulation of autophagy
|
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
DAPL1,
WASH1,
MET,
BCL2,
HGF,
MT3,
AKT1,
LEP,
HTR2B,
GATA4,
LEPR,
DAP,
MCL1,
GOLGA2,
SIRT2,
TAB3,
TBC1D14,
PTPN22
|
|
GO:0010508
|
BP
|
positive regulation of autophagy
|
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
ULK1,
DCN,
TFEB,
PIK3CB,
PRKAA2,
FOXO1,
BNIP3,
STK11,
MTDH,
TP53INP2,
TRIM22,
RNF152,
FLCN,
SVIP,
TBC1D5,
BAD,
TP53INP1,
TMEM59,
TRIM8,
PLK2,
SH3BP4,
SH3GLB1
|
|
GO:0010509
|
BP
|
polyamine homeostasis
|
Any biological process involved in the maintenance of an internal steady state of a polyamine.
|
EIF5A2
|
|
GO:0010510
|
BP
|
regulation of acetyl-CoA biosynthetic process from pyruvate
|
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
|
PDHA1,
DLD,
DLAT,
PDHB,
PDK1,
PDK4,
PDP1
|
|
GO:0010512
|
BP
|
negative regulation of phosphatidylinositol biosynthetic process
|
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol.
|
PDGFB,
PDGFA
|
|
GO:0010513
|
BP
|
positive regulation of phosphatidylinositol biosynthetic process
|
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol.
|
ZP3,
HTR2C,
HTR2B
|
|
GO:0010517
|
BP
|
regulation of phospholipase activity
|
Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.
|
SNCA
|
|
GO:0010518
|
BP
|
positive regulation of phospholipase activity
|
Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.
|
CYR61,
FGFR1,
FGFR2,
PLA2G5
|
|
GO:0010519
|
BP
|
negative regulation of phospholipase activity
|
Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.
|
RGS2
|
|
GO:0010523
|
BP
|
negative regulation of calcium ion transport into cytosol
|
Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
|
BCL2
|
|
GO:0010524
|
BP
|
positive regulation of calcium ion transport into cytosol
|
Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
|
CD4,
ADCYAP1R1,
CAV1,
TRPC3,
P2RX4
|
|
GO:0010529
|
BP
|
negative regulation of transposition
|
Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites.
|
APOBEC3G,
APOBEC3B
|
|
GO:0010531
|
BP
|
activation of JAK1 kinase activity
|
The process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it.
|
PIBF1
|
|
GO:0010534
|
BP
|
regulation of activation of JAK2 kinase activity
|
Any process that modulates the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it.
|
SOCS1
|
|
GO:0010535
|
BP
|
positive regulation of activation of JAK2 kinase activity
|
Any process that increase the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it.
|
AGT,
GH1,
CCL5
|
|
GO:0010543
|
BP
|
regulation of platelet activation
|
Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
|
SYK
|
|
GO:0010544
|
BP
|
negative regulation of platelet activation
|
Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
|
F2,
PDGFB,
APOE,
PDGFA,
PDGFRA,
NOS3,
C1QTNF1
|
|
GO:0010557
|
BP
|
positive regulation of macromolecule biosynthetic process
|
Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
|
MTPN
|
|
GO:0010559
|
BP
|
regulation of glycoprotein biosynthetic process
|
Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
|
BCL2
|
|
GO:0010560
|
BP
|
positive regulation of glycoprotein biosynthetic process
|
Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
|
IGF1
|
|
GO:0010564
|
BP
|
regulation of cell cycle process
|
Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
|
SOX9,
HMGA2,
SFRP1,
TXLNG
|
|
GO:0010565
|
BP
|
regulation of cellular ketone metabolic process
|
Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
|
PDK4
|
|
GO:0010569
|
BP
|
regulation of double-strand break repair via homologous recombination
|
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
|
CHEK1,
KDM1A,
PPP4C,
RAD51,
SPIDR,
RAD51AP1,
TEX15
|
|
GO:0010571
|
BP
|
positive regulation of nuclear cell cycle DNA replication
|
Any process that activates or increases the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.
|
CDC7,
WIZ,
ATRX,
DBF4B
|
|
GO:0010572
|
BP
|
positive regulation of platelet activation
|
Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
|
TLR4
|
|
GO:0010573
|
BP
|
vascular endothelial growth factor production
|
The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
HIF1A,
ADGRG1
|
|
GO:0010574
|
BP
|
regulation of vascular endothelial growth factor production
|
Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor.
|
IL6,
CCL2,
NDRG2
|
|
GO:0010575
|
BP
|
positive regulation of vascular endothelial growth factor production
|
Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.
|
C3,
TGFB1,
IL1A,
IL1B,
ATF4,
C5AR1,
ARNT,
ADORA2B,
PTGS2,
RORA,
FLT4,
BRCA1,
IL6ST,
GATA4,
HIF1A,
CYP1B1,
CCBE1,
SULF2,
SULF1,
HPSE
|
|
GO:0010579
|
BP
|
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
|
Any process that increases the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G-protein coupled receptor signaling pathway.
|
ADGRD1,
GPER1
|
|
GO:0010586
|
BP
|
miRNA metabolic process
|
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
|
BCDIN3D,
AGO4,
AGO2
|
|
GO:0010587
|
BP
|
miRNA catabolic process
|
The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
|
LIN28A
|
|
GO:0010591
|
BP
|
regulation of lamellipodium assembly
|
Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
|
CAPZB,
SSH2,
SSH3
|
|
GO:0010592
|
BP
|
positive regulation of lamellipodium assembly
|
Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
|
ARPC2,
HSP90AA1,
RAC2,
HDAC4,
RAC1,
FSCN1,
TWF2,
WASF2
|
|
GO:0010593
|
BP
|
negative regulation of lamellipodium assembly
|
Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
|
SLIT2
|
|
GO:0010594
|
BP
|
regulation of endothelial cell migration
|
Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
|
EMP2,
PTK2,
BMPER,
SEMA4A
|
|
GO:0010595
|
BP
|
positive regulation of endothelial cell migration
|
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
|
ITGB1BP1,
NRP1,
NRP2,
ROCK2,
PDCD6,
AGT,
ITGB3,
EDN1,
THBS1,
SPARC,
ANXA3,
BMP4,
TDGF1,
ETS1,
VEGFA,
PRKCA,
FLT4,
WNT5A,
RHOB,
GPLD1,
TEK,
BMPR2,
PRKD1,
ANGPT1,
CCBE1,
SCARB1,
PROX1,
ATOH8,
PRKD2,
FOXP1,
ZNF580
|
|
GO:0010596
|
BP
|
negative regulation of endothelial cell migration
|
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
|
KRIT1,
SLIT2,
BMP10,
APOH,
DCN,
THBS1,
SP100,
NR2F2,
PTPRM,
SERPINF1,
STC1,
SYNJ2BP,
DLL4
|
|
GO:0010603
|
BP
|
regulation of cytoplasmic mRNA processing body assembly
|
Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
|
ATXN2L
|
|
GO:0010606
|
BP
|
positive regulation of cytoplasmic mRNA processing body assembly
|
Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
|
CNOT1,
PAN3,
CNOT6
|