GO:0009408

BP

response to heat

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

MAP2K7, MSTN, TGFB1I1, DNAJA2, PSIP1, IGF1, IL6, HSP90AA1, CD14, HSPD1, CCL2, NOS3, DNAJA1, AKT1, CXCL12, GCLC, EIF2B5, EIF2B1, IGFBP7, MICB, MICA, DNAJA4, TP53INP1, CPB2, EIF2B3, DNAJB4, ASIC3, EIF2B4, TRPV2

GO:0009409

BP

response to cold

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.

FOS, IL6, LPL, ADRB2, HSP90AA1, ADRB1, HSPD1, THRA, ADRB3, ATP2B1, TRH, ADM, GMPR, PPARG, UCP3, CIRBP, CASP8, SLC27A1, PPARGC1A

GO:0009410

BP

response to xenobiotic stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.

AHRR, GPX1, AHR, GCLC

GO:0009411

BP

response to UV

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.

MAP2K7, USP1, UBE4B, TROVE2, TYR, POLD1, MAPK8, UBE2A, MSH6, UBE2B, PMAIP1, GTF2H2, CIRBP, KIAA0101, MAP4K3, CCAR2, ERCC4, PRIMPOL, TIPIN, RAD18, DTL, SERPINB13

GO:0009414

BP

response to water deprivation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.

TH, AKR1B1, CD9

GO:0009416

BP

response to light stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.

FOS, TH, ASNS, DRD2, JUND, ELK1, DUSP1, SLC1A3, POLG

GO:0009435

BP

NAD biosynthetic process

The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

NAMPT, QPRT, NADSYN1, NMNAT3, NMRK1

GO:0009436

BP

glyoxylate catabolic process

The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH.

AGXT

GO:0009437

BP

carnitine metabolic process

The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.

SLC22A5, CPT1A, CROT

GO:0009438

BP

methylglyoxal metabolic process

The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.

GLO1

GO:0009440

BP

cyanate catabolic process

The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid.

MPST

GO:0009441

BP

glycolate metabolic process

The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid).

IGF1

GO:0009443

BP

pyridoxal 5'-phosphate salvage

Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis.

PDXK

GO:0009444

BP

pyruvate oxidation

The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate.

NR4A3

GO:0009447

BP

putrescine catabolic process

The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine.

SAT1, SAT2

GO:0009448

BP

gamma-aminobutyric acid metabolic process

The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.

PHGDH

GO:0009449

BP

gamma-aminobutyric acid biosynthetic process

The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.

SLC1A3, ABAT

GO:0009450

BP

gamma-aminobutyric acid catabolic process

The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.

ABAT

GO:0009451

BP

RNA modification

The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.

PARN

GO:0009566

BP

fertilization

The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).

APOB, NR2F2, NLRP5, BAX, TDRD9, TEX15, SPTBN4, NECTIN3, DUOX2

GO:0009582

BP

detection of abiotic stimulus

The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.

TIMELESS

GO:0009583

BP

detection of light stimulus

The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.

OPN3

GO:0009584

BP

detection of visible light

The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.

GRM6, OPN1SW, ELOVL4, OPN3

GO:0009597

BP

detection of virus

The series of events in which a stimulus from a virus is received and converted into a molecular signal.

TLR3, SERINC3, SERINC5

GO:0009605

BP

response to external stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

INHA, PON1

GO:0009607

BP

response to biotic stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.

TMEM91, PRRT1

GO:0009609

BP

response to symbiotic bacterium

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism.

GPX1, PTAFR

GO:0009611

BP

response to wounding

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

NRP1, F2, PDGFB, TGFB1, FN1, PDGFA, VWF, CYP1A1, CCL2, ITGB4, GAP43, MDK, FGF7, TNC, F2R, ZFP36, CTGF, ADM, SLC1A3, SLC1A2, ZFP36L2, TGFB2, RAC1, CDK5, FABP5, POU5F1, ID3, DST, HHEX, ZFP36L1, GRIN2A, SRSF5, SULF2, NMNAT3, LYVE1

GO:0009612

BP

response to mechanical stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

ANGPT2, COL3A1, BGLAP, MPO, JUN, DCN, THBS1, ASNS, INHBB, GLI2, CCL2, CCNB1, ETS1, FOSL1, JUNB, JUND, IGFBP2, TNC, PTGER4, CHI3L1, TGFBR2, PPARG, GATA4, CXCL12, MMP14, CLCN6, FOSB, BTG2, PTCH1, POSTN, SOST, TXNIP, TRPV4, RETN, DNAH1

GO:0009615

BP

response to virus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.

DDX3X, DCLK1, BANF1, PRKRA, URI1, TNF, APOB, HSPB1, CYP1A1, ENO1, CHRM2, FGR, CLU, ODC1, IFITM1, CCL4, CCL5, TPT1, CCDC130, IFNGR1, FOSL1, STMN1, HMGA1, IFNAR1, BCL3, TNFSF4, CFL1, PSMA2, IL12A, GTF2F1, IFNGR2, CXCL12, IFNAR2, HMGA2, CXCR4, NPC2, AP1S1, RPS15A, ACTA2, CCL8, CDK6, IFITM3, MEF2C, BST2, HYAL2, TRIM22, LILRB1, IFI44, ISG20, HNRNPUL1, FOXP3, DHX36, DUOX2, TBK1, IRAK3, IVNS1ABP

GO:0009617

BP

response to bacterium

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

WASL, RAB29, SNX3, CCL2, ADH7, SLC11A1, SERPINB9, CAV1, CD47, CHIT1, FUCA2, ERAP1, BAIAP2L1

GO:0009620

BP

response to fungus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.

BCL10

GO:0009624

BP

response to nematode

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode.

CYP1A1, ITLN1

GO:0009628

BP

response to abiotic stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.

TIMELESS

GO:0009629

BP

response to gravity

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.

MSTN, FOS, BGLAP, SPARC, FOSL1

GO:0009635

BP

response to herbicide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.

CYP1A1, TH, ALAD, STAR

GO:0009636

BP

response to toxic substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

DHX15, NUPR1, TLR2, AIFM1, CST3, FOS, PENK, TYMS, CDK1, EPHX1, LYN, ASNS, CNP, PDGFRB, CCL3, BCL2, CDK4, CCL4, CCL5, DRD2, NQO1, SDC1, XPA, MPST, FAS, PON1, MAOB, MAPK3, MAPK1, SLC6A1, CHKA, AHR, CDKN1A, MDM2, SLC18A2, RAD51, BAX, SRSF9, BLMH, SCN9A, CYP1B1, WAPL, TRPM6, DNMT3B, HDAC6, SLC7A8, SLC6A14, SLC7A11

GO:0009644

BP

response to high light intensity

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.

RDH13

GO:0009645

BP

response to low light intensity stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2.

HMGCS1

GO:0009648

BP

photoperiodism

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species.

NMU

GO:0009649

BP

entrainment of circadian clock

The synchronization of a circadian rhythm to environmental time cues such as light.

PER1, GNA11, GNAQ, ARNTL2

GO:0009650

BP

UV protection

Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV.

GPX1, ERCC1, ERCC2, FEN1, ERCC4, SDF4

GO:0009651

BP

response to salt stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.

KMO, TNF, TH, HSP90AA1, HSP90AB1, BAX

GO:0009653

BP

anatomical structure morphogenesis

The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

IGF2BP3, CYR61, EREG, MPZL2, TRIM13, GPC4, FGF18, EYA4, PTBP3, WHSC1, KRT18, TH, HOXB5, CPM, LIG1, F2R, MCAM, IER3, HOXA1, EFNB2, HIRA, TPD52, RAC1, DYNLL1, PKD1, POU5F1, PAX8, MAB21L1, NFE2L1, FAT1, NEDD8, ZNF141, FSCN1, SFRP5, FBN3, SIAH1, CSGALNACT1, EZH1, BICD1, S1PR3, MRPL40, DKK3, SCML1, ERVW-1, SCML2, LYVE1, IGF2BP2

GO:0009692

BP

ethylene metabolic process

The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.

CYP1A1

GO:0009725

BP

response to hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.

TIMP1, ANG, LYN, HCLS1, TIMP2, ADRA1A, NKX2-1, UQCRFS1, GCLC, MMP14, OXCT1, SNRPN, H3F3A, SORD, DHCR24, SFRP4, GHSR, RERG, MMP19, PITX2, TXN2, GHRL

GO:0009743

BP

response to carbohydrate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.

CST3, IL1B, APOB, LYN, MDM2

GO:0009744

BP

response to sucrose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.

ERCC1, SLC6A1, ADIPOQ

GO:0009749

BP

response to glucose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.

ANGPT2, ENSA, PFKFB2, LDHA, TGFB1, APOA2, LPL, THBS1, COL6A2, GJA1, PFKL, EGR1, TRH, CTGF, SREBF1, TGFBR2, CDKN1B, GYS2, SESN2, PTEN, VAMP2, GPLD1, COL4A3, PPARD, EIF2B5, ACVR2B, EIF2B1, NR0B2, SMAD2, ADIPOQ, SARM1, ILDR2, SLC30A8, BAD, TXN2, VIMP, TXNIP, GPAM, TCF7L2, EIF2B3, EIF2B4, IRS2

GO:0009750

BP

response to fructose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus.

SLC2A5, PTGS2

GO:0009755

BP

hormone-mediated signaling pathway

A series of molecular signals mediated by the detection of a hormone.

AGRP, NR5A2, LATS1, THRA, TRH, LHCGR, FSHR, NUP62, PTPN11, ADIPOR2, GHSR, ADIPOR1, LATS2, GHRL

GO:0009756

BP

carbohydrate mediated signaling

A series of molecular signals mediated by the detection of carbohydrate.

COLEC12, CLEC7A

GO:0009785

BP

blue light signaling pathway

The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm.

CRY1

GO:0009786

BP

regulation of asymmetric cell division

Any process that modulates the frequency, rate or extent of asymmetric cell division.

POU5F1

GO:0009790

BP

embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.

NR5A2, BMP2, TDGF1, RASA1, TGFB2, NRG1, PTK2, TDG, RICTOR, UBR3, MDFI, RACGAP1, PDGFC, USP22, RAI2

GO:0009791

BP

post-embryonic development

The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.

FOXP2, APOB, BCL2, IGF2R, BMP4, ERCC2, FGFR2, SOX6, TGFBR1, NR4A2, PSEN1, SEPP1, GNAQ, SLC18A2, ACVR2B, MORC3, ITPR1, ARID5B, SMAD2, SCN9A, GIGYF2, SCUBE1, PPP1R13L, CCDC47, CSRNP1, SEMA3C, PYGO2, RC3H2, CHST11, DHCR7, KDM5B, AGO2, HEG1, MAPK8IP3

GO:0009792

BP

embryo development ending in birth or egg hatching

The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.

CYP1A1, FXN

GO:0009798

BP

axis specification

The establishment, maintenance and elaboration of a pattern along a line or around a point.

WNT6

GO:0009804

BP

coumarin metabolic process

The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids.

CYP1A1, CYP2D6, CYP2A6

GO:0009812

BP

flavonoid metabolic process

The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins.

CYP1A1, SULT1A3

GO:0009813

BP

flavonoid biosynthetic process

The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton.

UGT2B4, UGT2A3

GO:0009817

BP

defense response to fungus, incompatible interaction

A response of an organism to a fungus that prevents the occurrence or spread of disease.

TGFB1

GO:0009820

BP

alkaloid metabolic process

The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).

CYP2D6

GO:0009822

BP

alkaloid catabolic process

The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).

CYP3A4, CYP2D6, CYP3A5

GO:0009838

BP

abscission

The controlled shedding of a body part.

IST1, SPG20, AURKB, ZFYVE19

GO:0009855

BP

determination of bilateral symmetry

The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.

ALDH1A2

GO:0009880

BP

embryonic pattern specification

The process that results in the patterns of cell differentiation that will arise in an embryo.

LRP6, FGFR2, SMAD3, ZBTB16, SIM2, ERBB4, SMAD1, PGAP1, DISP1, SMAD5

GO:0009887

BP

animal organ morphogenesis

Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

ABLIM1, NRP1, TNFSF11, EREG, PAX4, GMNN, PDGFA, TH, DCN, FGF2, BMP2, CCL2, ITGA2, ITGAX, COL9A1, FGFR2, STX2, COL18A1, SYK, CRKL, COMP, VEGFC, GSK3B, EFNB2, HCCS, NLRP5, RELA, NOTCH2, TLE1, TLE3, AES, EP300, PTCH1, FHL1, DGCR6, TMEM176B, PHLDA2, NEK8, SMARCC1, SEMA6A, PDGFC, TRPS1, EVL

GO:0009888

BP

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

NR5A2, MBD3, GAA, WT1, DHCR24, TNFRSF19, TRPS1, CNPY2

GO:0009890

BP

negative regulation of biosynthetic process

Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.

GSTP1

GO:0009893

BP

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

PIGA

GO:0009912

BP

auditory receptor cell fate commitment

The process in which the cellular identity of auditory hair cells is acquired and determined.

NOTCH1

GO:0009913

BP

epidermal cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.

KLF4, HDAC1, HDAC2

GO:0009948

BP

anterior/posterior axis specification

The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.

AURKA, BMP4, SKI, CTNNB1, WNT3, WLS, PGAP1

GO:0009950

BP

dorsal/ventral axis specification

The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.

AXIN1, CTNNB1, BMPR1A, WNT3, SFRP1, MDFI

GO:0009952

BP

anterior/posterior pattern specification

The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.

HOXA2, HOXA3, TBX1, LRP5, TULP3, ALDH1A2, HOXC4, HOXB5, GLI2, GLI3, NR2F2, YY1, ACVR2A, HOXD10, HOXA10, HOXA6, TGFBR1, PBX1, CRKL, BTG2, HHEX, EMX2, ZBTB16, RING1, GRSF1, ACVR2B, BMPR2, SMAD2, TSHZ1, ARC, PCSK5, HIPK2

GO:0009953

BP

dorsal/ventral pattern formation

The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.

HOXA2, EDN1, LHX2, PTCH1, DUSP6, DISP1, HHIP, FBXL15

GO:0009954

BP

proximal/distal pattern formation

The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).

GREM1, ALDH1A2, GLI2, GLI3, HOXD10, HOXA10, CTNNB1, PBX1, PBX2, DLX2, CHSY1, CYP26B1

GO:0009956

BP

radial pattern formation

The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur.

NR2F2

GO:0009957

BP

epidermal cell fate specification

The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.

PTCH1

GO:0009966

BP

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

SOCS2, BIRC5, FURIN, TDGF1, NUP62, PPP1R2, NCLN, VWCE, MGLL, TSPYL2, CDC42SE2, GLRX2

GO:0009967

BP

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

SOCS2, IRS4, ARHGAP6, SKAP2, PTH, CHN1, SH3BGR, ADAMTS20, GRB2, KHDRBS1, EPS8, GRB14, SHB, ADIPOQ, LDLRAP1, HOMER1, BLNK, STAM, SORBS1, SH2B1, PAG1, CDKN2AIP, ITSN2, HDAC6, VAV3, MAPK8IP1, SH2B3

GO:0009968

BP

negative regulation of signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.

RGS12, RGS5, RGS10, SOCS5, IGFBP3, ERBB3, RGS7, ACVR1, RGS7BP, RGS22, UBASH3B, INPP5D, HHIP, PAK1IP1

GO:0009972

BP

cytidine deamination

The removal of amino group in the presence of water.

APOBEC3G

GO:0009987

BP

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

APP, TUBB, MAP1B, HDGFL1

GO:0009988

BP

cell-cell recognition

Cell recognition between cells. May involve the formation of specialized cell junctions.

CD209

GO:0009991

BP

response to extracellular stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

NOCT

GO:0009992

BP

cellular water homeostasis

Any process involved in the maintenance of an internal steady state of water within a cell.

AQP9, AQP8, MIP, AQP2, AQP3

GO:0009994

BP

oocyte differentiation

The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.

LGR5, KMT2B

GO:0010001

BP

glial cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.

NFIB, GAP43, CDH2, DNER, KLF15, MMP24

GO:0010002

BP

cardioblast differentiation

The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.

TGFB2

GO:0010021

BP

amylopectin biosynthetic process

The chemical reactions and pathways resulting in the formation of amylopectin, the (1->4) linked alpha glucose units with alpha-(1->6) linkages.

SLC2A4

GO:0010025

BP

wax biosynthetic process

The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids.

FAR2

GO:0010032

BP

meiotic chromosome condensation

Compaction of chromatin structure prior to meiosis in eukaryotic cells.

SMC2, NCAPD3, NCAPD2, SMC4

GO:0010033

BP

response to organic substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

SUPT5H, AQP9, ANXA5, CREB1, GART, S100P, PPP2R1A, TIMP3, WNT5A, CTSC, RELA, SQLE, GLRX2, HDAC6

GO:0010035

BP

response to inorganic substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.

GART, EEF1A2

GO:0010038

BP

response to metal ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.

MT2A, MT3, MT1X, MTF1, NDRG1, NEDD4L

GO:0010039

BP

response to iron ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.

APBB1, C1QA, BCL2, ALAD, DRD2, CPOX, SLC11A2, ABAT, HAMP, MDM2, FXN, HFE, CYBRD1, TFR2

GO:0010040

BP

response to iron(II) ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus.

SNCA

GO:0010041

BP

response to iron(III) ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus.

CYP1A1, G6PD