GO:0007529

BP

establishment of synaptic specificity at neuromuscular junction

The biological process in which a synapse between a motor neuron and a muscle is initially formed.

F2R

GO:0007530

BP

sex determination

Any process that establishes and transmits the specification of sexual status of an individual organism.

TCF21, AMH, SRD5A1, WT1, CITED2

GO:0007548

BP

sex differentiation

The establishment of the sex of an organism by physical differentiation.

AMH, CYP17A1, AR, PBX1, AMHR2

GO:0007549

BP

dosage compensation

Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes.

H2AFY, H2AFY2

GO:0007565

BP

female pregnancy

The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.

CLDN4, AGT, FOS, TGFB1, GNRH1, FSHB, PRL, AMBP, STS, BCL2, UMPS, PTHLH, ETS1, FOSL1, HPGD, ITGA2, IGFBP2, COMT, IGFBP5, CAD, OXTR, ADM, LEP, NAMPT, PGF, STAT5B, FOSB, UCP2, HSD11B2, DHODH, COL16A1, PSG7, PAPPA, PSG3, HFE, ADIPOR2, UPRT, TEAD3, EPYC, CLIC5, LNPEP, MAGED2

GO:0007566

BP

embryo implantation

Attachment of the blastocyst to the uterine lining.

STC2, RECK, CST3, IL1B, MMP2, SPP1, MMP9, LIF, PRLR, FBLN1, PTGS2, BSG, TGFBR2, RPL29, STC1, EMP2, NLRP5, H3F3A, FKBP4, PPARD, DDR1, TRIM28, IGFBP7, PTGIS, PCSK5, VMP1

GO:0007567

BP

parturition

The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.

HPGD, PTAFR, PTGFR, NRK, MAFF, PLA2G4C

GO:0007568

BP

aging

A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).

FOXO3, MBD3, ADA, ASS1, AGT, TIMP1, FOS, TGFB1, GNRH1, PENK, COL3A1, CRYAB, AMH, HMGCR, NTRK1, CYP1A1, TYMS, APOD, ITGB2, SERPING1, MPO, EIF2S1, IL6, JUN, DCN, KRT16, IGFBP1, CNP, DLD, CCL2, EEF2, ENO3, ADRB3, NQO1, TIMP2, CREB1, JUND, IGFBP2, ERCC2, VCAM1, ATP2B1, TNFRSF1B, CNR1, IL10, IGFBP5, CANX, CTGF, TSPO, AKT1, CTNNA1, ADM, ADRA1A, PCK1, NUDT1, SERPINF1, SREBF1, TGFBR2, SNCA, STAT3, GCLC, GCLM, NPY2R, CDKN1C, IRAK1, CTSC, POLG, SLC12A2, CASP9, FOXG1, UCP2, UCP3, PTEN, GRB2, ABAT, HAMP, FOXO4, RELA, PDE4D, EIF2B5, RGN, NPY5R, NAPEPLD, TPRA1, CARM1, AURKB, LITAF, CACYBP, RETN, GLRX2, PPARGC1A, KL, AMFR, TRPC6, LOXL2

GO:0007569

BP

cell aging

An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).

BGLAP, TP53, ICAM1, CDK1, NPM1, BCL2, MIF, NUP62, LIMS1, BRCA2, ILK, MORC3, PDCD4, MNT, NOX4, ZMIZ1

GO:0007584

BP

response to nutrient

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

TNFRSF11B, GNPAT, OGT, ENSA, ACSL4, ABCA1, LDHA, ASS1, SERPINC1, APOA1, HMGCR, CYBB, GNAI2, ERCC1, NQO1, ARSB, IGFBP2, VCAM1, CNR1, AHCY, ADSL, SSTR1, ACSL1, HMGCL, TGFBR2, PPARG, AKR1C3, GCLC, GCLM, STAR, OXCT1, UCP3, PTEN, DAD1, HSF1, ADIPOQ, SLC27A4, AACS, ADIPOR2, TXN2, ABCG8, LIPG

GO:0007585

BP

respiratory gaseous exchange

The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.

EDN1, BPGM, COX5B, SFTPC, CFTR, EDNRA, HNMT, NDST1, UCP3, FUT8, CHST11, DACH1, MAPK8IP3, MAFB, COX11

GO:0007586

BP

digestion

The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

PRSS1, AMY2B, SSTR1, CCKBR, PRSS3, NMU, AKR1C2, AKR1C1, SULT2A1, CTRB2, PPARGC1A

GO:0007588

BP

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

NPHP1, AQP9, NFAT5, HMOX1, ADORA2B, AVPR2, AQP2, SCNN1G, CLCN5, CLCNKA, CLCNKB, AQP3, SLC22A18, NEDD4L, ABCG8, GRHPR

GO:0007589

BP

body fluid secretion

The controlled release of a fluid by a cell or tissue in an animal.

EDN1, ANXA2, NPPB, GUCA1B

GO:0007595

BP

lactation

The secretion of milk by the mammary gland.

SERPINC1, PRL, RPLP0, APRT, UMPS, VDR, VEGFA, CREB1, PRLR, PAM, CAD, OXTR, STAT5A, XDH, STAT5B, DHODH, CAV1, PPAT, DDR1, ERBB4, NCOA1, USF2, HIF1A, CDO1, GPAT4, UPRT, SLC29A1, APLN

GO:0007596

BP

blood coagulation

The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

MAFG, RAD51C, AKAP10, KDM1A, JAK2, MFN2, PAPSS2, F8, F13A1, F2, PLG, PLAU, PLAT, SERPINC1, SERPINA1, IFNA1 , COL1A1, FGA, FGB, FGG, VWF, IFNA16, ITGB3, SERPINA5, F13B, FYN, SERPINE2, LYN, COL1A2, ANXA5, PRKAR1A, TFPI, IRF1, F5, GP1BB, PRKAR2A, CD36, ITGA2, PRKACA, RAB5A, F2R, PRKAR2B, GGCX, GATA4, CBX5, CAPZB, TFPI2, GNAQ, RAB27A, CAPZA1, F2RL1, CDC42, RAC1, HIST1H3D, HBB, HBG1, H3F3A, GNA12, PLAUR, MMRN1, HDAC1, ITPK1, JMJD1C, ANO6, DOCK11, LRRC16A, SCUBE1, CD177, DOCK8, ZFPM2, AKAP1, HDAC2, GATA6, DOCK6, CPB2, P2RX4, VKORC1, LNP, PDGFD, HPS4, PDGFC, SH2B1, EHD3, HMG20B, AK3, BLOC1S6, MAFF, PROCR, SH2B3, ENPP4

GO:0007597

BP

blood coagulation, intrinsic pathway

A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X.

F8, F2, A2M, KNG1, APOH, VWF, SERPING1, GP1BB, C1QBP

GO:0007598

BP

blood coagulation, extrinsic pathway

A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X.

TFPI

GO:0007599

BP

hemostasis

The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.

VWF, GPI, AVPR2, HPS4

GO:0007600

BP

sensory perception

The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.

PENK, CCKBR, OPRL1, ASIC3, TRPV2

GO:0007601

BP

visual perception

The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

GRM8, ABLIM1, PDE6D, OPA1, AOC2, RP2, DHRS3, BEST1, EYA4, EML2, GUCA1C, COL1A1, RBP4, OPN1SW, TH, COL11A1, TYR, ATF6, PDC, CHM, CNGA1, MIP, TIMP3, GJC1, COL18A1, GLRB, PPT1, LUM, RABGGTB, PITPNA, NDP, GUCY2D, CRYZ, EFEMP1, PDCL, UNC119, TGFBI, CYP1B1, FAM161A, SFRP5, DRAM2, CYP4V2, BBS7, RDH10, ZNF513, BBS1, WDR36, BBS10, GPR98, RPGR, HPS1, DNAJC19, EPAS1, BBS2, MKKS, DLL4, CLN6, SPATA7, NOB1, GUCA1B, SLC45A2, MYO5A, OCLM, LAMC3

GO:0007602

BP

phototransduction

The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.

OPN1SW, PDC, UNC119, TRPC3, ASIC2, CDS1, OPN3, PLEKHB1, GUCA1B

GO:0007603

BP

phototransduction, visible light

The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.

GNA11, GNAQ

GO:0007605

BP

sensory perception of sound

The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.

SOBP, COCH, TBX1, ATP8B1, SPRY2, SNAI2, TBL1X, WDR1, TECTA, LRIG2, EYA4, EML2, COL1A1, ICAM1, TH, GPX1, FGFR1, COL11A1, COL11A2, GABRA5, SLC1A3, CDKN1B, ALDH7A1, HOXA1, RPL38, NDP, COL4A3, TJP1, ASIC2, NIPBL, USP53, PGAP1, NAV2, CCDC50, CEMIP, GPR98, LRIG1, FAM107B, SPTBN4, SLC52A3, CLIC5, CHD7, DCDC2, FZD4, MYO6, FAM65B

GO:0007606

BP

sensory perception of chemical stimulus

The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.

C5AR1, GNAS, GNAS

GO:0007608

BP

sensory perception of smell

The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.

GRM8, NCAM2, ADCY3, DRD2, UBR3, NAV2, OR2A5, MKKS, B3GNT2

GO:0007610

BP

behavior

The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.

CCL3, HTR2B, TRMT1L

GO:0007611

BP

learning or memory

The acquisition and processing of information and/or the storage and retrieval of this information over time.

EGFR, PRNP, S100B, NTRK1, GPI, THRA, EGR2, GM2A, SLC11A2, AFF2, PTEN, MEF2C, GRIN2A, AMFR

GO:0007612

BP

learning

Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.

UBA6, SYNJ1, PARK2, JUN, FYN, TH, FOSL1, ARF4, COMT, EPHB2, SLC6A1, PRKAR2B, PTGS2, DLG4, NTRK2, ARC, NLGN4X, ATAD1, FGF13, PAK7, EIF2AK4, NRXN1

GO:0007613

BP

memory

The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).

MUSK, S100B, TH, ITGA5, NQO2, CREB1, CEBPB, CNR1, ITGA3, OXTR, PTGS2, HRH1, CHRNA7, FEN1, PSEN1, PTEN, VLDLR, GRIN2A, EIF4EBP2, ITPR3, ATAD1, FGF13, PAIP2, PLCB1, PLK2, PAK7, KMT2B

GO:0007614

BP

short-term memory

The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.

MDK, COMT, SERPINF1

GO:0007616

BP

long-term memory

The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.

DRD2, CPEB3, BTBD9, EIF2AK4

GO:0007617

BP

mating behavior

The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.

APP, TH, MTNR1A, MAPK8IP2

GO:0007620

BP

copulation

The act of sexual union between male and female, involving the transfer of sperm.

ABAT

GO:0007622

BP

rhythmic behavior

The specific behavior of an organism that recur with measured regularity.

EGR2

GO:0007623

BP

circadian rhythm

Any biological process in an organism that recurs with a regularity of approximately 24 hours.

AGRP, ARNTL, CLDN4, HDAC3, PER1, PAX4, HNRNPR, NCOR1, EGFR, NTRK1, TYMS, SERPINE1, JUN, TOP1, CDK4, CREB1, JUND, NR1D1, FAS, HTR7, SREBF1, ID1, LEP, NAMPT, ID4, MTNR1A, NRIP1, MTNR1B, GSK3B, CPT1A, ID3, EGR3, EP300, KLF10, KLF9, NONO, ADIPOQ, NTRK2, NFIL3, SETX, TPH2, ARNTL2, PROX1, NPAS2, RBM4B, PPARGC1A, NOCT, TIMELESS, THRAP3

GO:0007625

BP

grooming behavior

The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.

APRT, DRD2, PPT1

GO:0007626

BP

locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

UBA6, SOBP, MEIS1, GRM6, APP, TH, GAA, DRD2, TAL1, NPY1R, HTR2C, ETV5, NKX2-1, ALDH1A3, NPY2R, SEPP1, NOVA1, PTEN, SNAP25, ABAT, NRG1, APBA1, SLC18A2, NAV2, RASD2, ALS2, ANKH, GPRC5B, PAK7

GO:0007628

BP

adult walking behavior

The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.

NPC1, DAB1, UCHL1, MAPT, DRD2, TRH, GLRB, EPHA4, ZIC1, FXN, ABHD12, OXR1, SPTBN4, HIPK2, CHD7

GO:0007631

BP

feeding behavior

Behavior associated with the intake of food.

AGRP, GCG, FYN, DRD2, GAL, NPY1R, HTR2C, CCKBR, MC4R, NPY2R, NPY5R, NTRK2, GIGYF2, MRAP2

GO:0007632

BP

visual behavior

The behavior of an organism in response to a visual stimulus.

NPHP1, SLC1A2

GO:0007634

BP

optokinetic behavior

The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus.

HOXA1

GO:0007635

BP

chemosensory behavior

Behavior that is dependent upon the sensation of chemicals.

TRPV1

GO:0007638

BP

mechanosensory behavior

Behavior that is dependent upon the sensation of a mechanical stimulus.

ETV1, STRBP

GO:0008015

BP

blood circulation

The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.

TBC1D8, CYB5R3, SERPING1, F5, NPY1R, PLN, HTR7, ADM, MTHFR, CXCL12, RCAN1, OLR1, COL4A3, DLL4, CHD7

GO:0008016

BP

regulation of heart contraction

Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.

FXYD1, CELF2, TH, CHRM2, TPM1, THRA, DES, PLN, SRI, DMPK, CAMK2D, KCNJ12, HBEGF, HOPX, KCNIP2

GO:0008033

BP

tRNA processing

The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

POP7, FARS2, POP4, SARS, LSM6, RPP30, GRSF1, KARS, TYW3, PUS7, TP53RK, TPRKB

GO:0008037

BP

cell recognition

The process in which a cell in an organism interprets its surroundings.

VCAN, PVR, PECAM1, CD200, SMAGP, NECTIN1, CSGALNACT1, CLEC7A, CADM1, NECTIN3

GO:0008045

BP

motor neuron axon guidance

The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.

HOXA2, KIF5C, SLIT2, ERBB2, EGR2, CHN1, EPHA4, CDK5, ALCAM, RNF165

GO:0008050

BP

female courtship behavior

The behavior of a female, for the purpose of attracting a sexual partner.

THRA

GO:0008053

BP

mitochondrial fusion

Merging of two or more mitochondria within a cell to form a single compartment.

OPA1, MFN2, BAX, FAM73A, MFF

GO:0008057

BP

eye pigment granule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye.

SHROOM2

GO:0008063

BP

Toll signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

PELI1, PELI2

GO:0008064

BP

regulation of actin polymerization or depolymerization

Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.

CXCL12, SSH2, SSH3

GO:0008065

BP

establishment of blood-nerve barrier

The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier.

GSTM3

GO:0008088

BP

axo-dendritic transport

The directed movement of organelles or molecules along microtubules in neuron projections.

APP, MAPT, APBA1, KLC3

GO:0008089

BP

anterograde axonal transport

The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.

AP3D1, KIF1B, KIF4A, SNAPIN, AP3M2, AP3S2, BLOC1S1, BLOC1S3, MGARP, SPAST, RAB21, BLOC1S6, AP3M1

GO:0008090

BP

retrograde axonal transport

The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.

SNAPIN, MGARP, NDEL1

GO:0008104

BP

protein localization

Any process in which a protein is transported to, or maintained in, a specific location.

AKAP10, KIF5C, ULK1, TP53, NPM1, DRD2, TSC2, NR0B1, IST1, CD81, CAV1, GRIN2A, SQSTM1, DHCR24, NEDD8, CROCC, BBS7, NRCAM, KIFAP3, ALS2, BBS2, CLIC5, AKAP7, SLC9A2, MLH3, MAPK8IP3, AKAP2

GO:0008105

BP

asymmetric protein localization

Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically.

COLQ

GO:0008150

BP

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

TMEM129, TMEM120B, ILVBL, SBNO1, NUDT19, MATN2, DSCR3, KHNYN, FYB, CTDSPL, ABCC4, FLRT2, PI15, SGTA, CALU, AHCYL1, ZNF862, ZFAND5, SORBS2, PROSC, SFT2D2, LRG1, A1BG, PRB1, NUDT7, HIST1H2AG, ZNF688, TPR, HIST1H2AD, BGN, MST1, TM4SF1, SDC2, SLC6A8, MEOX1, LRBA, TMEM50B, EPPK1, SNRPN, MRPS10, SERF2, ZXDB, ZNF200, REEP5, LMNB2, ELP6, MN1, NPRL3, SCGB2A2, COTL1, FAM53B, TMEM187, NOMO1, PPP1R7, FAM189A2, ZNF77, CCDC6, TMEM132A, QRICH1, LRRFIP1, FILIP1L, ARID4B, LRRC23, TMEM35, ANKRD39, BOLA3, TMEM128, NOM1, SLC25A30, IDNK, ANKRD45, CDKAL1, ANKRD40, HIST2H2AA3, TTC27, INO80C, WDR74, SBSN, C5orf46, TMEM107, TMEM108, HSDL2, TMEM91, FAM65A, LHFPL2, PTCHD4, USP53, H2AFV, SLC35D2, KNDC1, TMC6, KDELC2, THNSL2, CARKD, SLC35F2, THNSL1, BEST3, TMEM256, TMEM132C, ZADH2, TMEM57, FAM184A, PDDC1, SLC43A3, GSTCD, ABHD11, WDR36, AGR3, DNAH5, SCFD2, CHAC2, SNRNP27, FAM3C, DCUN1D4, NR4A3, LPGAT1, DPF3, LPP, TMEM106A, KIAA1191, EXOSC8, FLYWCH2, DTD2, DCUN1D1, ZNF486, CYYR1, ZNF75A, ZFP3, KLHL5, CDCA3, TMEM47, TMEM121, H2AFJ, HGH1, C9orf16, TMEM106C, TMEM120A, FSD1L, EMILIN2, RTFDC1, ASPSCR1, UACA, GPR63, PLA2G12A, UBXN6, TM6SF1, ZC3H12C, KLHL4, C20orf27, C6orf62, MKRN2, SPATC1L, CYSTM1, ADAMTS10, TMEM245, GHITM, PLEKHA4, C11orf1, FAM96A, SEC61A2, PLEKHA5, POPDC2, POPDC3, MAGEE1, TMEM8A, EPB41L4A, CD248, MRPL47, RETN, APMAP, IFT46, MXRA5, STRN4, SMCO4, INPP5E, TM7SF3, TMEM51, C1orf123, VNN3, DONSON, MIS18A, GLTSCR2, SEPN1, EMC3, AKAP7, TMEM9, SIPA1L2, IMPACT, STOML1, ARPP21, ZMYM2, CFDP1, EPHA6, FETUB, GPATCH8, C14orf1, EXOG, DIP2C, EPB41L3, RCL1, MRPS28, CCDC53, ZNF330, GPSM3, AIM1, AMMECR1, LRRFIP2

GO:0008152

BP

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

INSIG1, AQP9, DXO, PRNP, UGT2B4, GSTA1, CPE, PCSK1, DIP2A, CENPV, ECHDC3, L3HYPDH, FAHD2A, TMEM68, ACSS3, ECHDC1, STARD9, SPAST, GRHPR, ENPP5, DIP2C

GO:0008154

BP

actin polymerization or depolymerization

Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.

WASL, DSTN, ABI1, GHSR, ABI2, GHRL, EVL

GO:0008156

BP

negative regulation of DNA replication

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.

GMNN, TGFB1, S100A11, NF2, TERF1, PDS5A, WAPL, CDC6, TSPYL2

GO:0008202

BP

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

HSD17B6, CYP1A1, CYP17A1, CYP2E1, CYP3A4, CYP21A2, SULT1A3, CYP2D6, CYP2A6, CYP2C9, CYP2B6, CYP3A5, CYP3A7, TSPO, G6PC, AKR1C3, AKR1C2, SULT2A1, STARD3, MSMO1, CYP1B1, DHRS4

GO:0008203

BP

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

NPC1, LRP5, ERLIN2, ABCA1, CH25H, LDLR, APOA1, APOE, APOA2, APOC1, APOB, APP, CYP11A1, FDX1, CYP11B1, CYP11B2, TNFSF4, PON1, SOAT1, SREBF1, LEP, LEPR, STAR, NPC2, VLDLR, HDLBP, PPARD, LIPE, APOBR, SREBF2, STARD3, EBP, NR0B2, LDLRAP1, PCSK9, SORL1, APOL2, OSBPL1A, CLN6

GO:0008206

BP

bile acid metabolic process

The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

NR5A2, NPC1, ATP8B1, LEP, FABP6, AKR1C1, NR1H4, GBA2

GO:0008209

BP

androgen metabolic process

The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.

ESR1, CYP3A4, CYP19A1, SRD5A2, ADM, HSD17B4, DHRS9, PPARGC1A

GO:0008210

BP

estrogen metabolic process

The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.

HSD17B1, COMT, HSD17B4, CYP1B1

GO:0008211

BP

glucocorticoid metabolic process

The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

APOA1, STAR

GO:0008217

BP

regulation of blood pressure

Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

LRP5, AGT, POMC, SOD2, COL1A2, HMOX1, ACE, CYP11B1, GNB3, NPPB, NPR3, NPR2, PTGS1, EDNRA, NPY1R, NOS3, PTGS2, PPARG, LEP, AGTR2, ATP1A2, ACTA2, HBB, ACSM3, ERAP2, AGTRAP, P2RX4, ERAP1, LNPEP, NISCH

GO:0008218

BP

bioluminescence

The production of light by certain enzyme-catalyzed reactions in cells.

SDC2

GO:0008219

BP

cell death

Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).

AXIN1, BRINP1, BCL10, HMOX1, FOSL2, NUP62, PTGER3, EMP1, EMP2, EMP3, TGFB2, PMP22, BNIP3, CLUL1, FBXO18, SUSD6, OPTN, ALS2, PRKD2, PNPLA8, ZAK, VAPA, FAF1, SNCAIP

GO:0008228

BP

opsonization

The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody.

CRP, C4A, C4B, MBL2, PTX3, CD47, FCN2, SPON2

GO:0008272

BP

sulfate transport

The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

SLC26A2, SLC26A11, RACGAP1, SLC26A1

GO:0008277

BP

regulation of G-protein coupled receptor protein signaling pathway

Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.

RGS12, RGS5, GNG7, RAMP1, RAMP3, TULP3, GRK5, RGS2, GRK6, RGS3, RGS4, GNG4, DYNLT1, PDCL, GIT2, GPR158, GPSM1, PLCB1, USP20, GIT1

GO:0008283

BP

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

E2F8, BIN1, CYR61, PDXK, MDM4, POLR3G, INSIG1, TBX1, BUB1, NRDC, KDM1A, BUB1B, DKC1, NBN, ZPR1, TACC1, GPC4, CREG1, TUSC2, UBR5, TACC2, EGFR, TGFA, PRL, GCG, IL1A, RAF1, CD74, S100B, ERBB2, TP53, CYP1A1, TYMS, GNAI2, IGF1, CDK1, CSF1R, ERCC1, MET, KRT16, CXCL1, POLA1, UCHL1, FURIN, GLI2, AR, TXN, PCNA, SKI, XRCC5, MIF, TYR, AREG, ITGA2, ERCC2, CHRM3, CDK11B, KITLG, IGFBP4, DTYMK, ADRA1D, EDNRA, MT3, LTK, CDC27, CDC25A, CDC25C, TSPO, AKT1, CCKBR, CKS2, MCM7, ADRA1B, SERPINF1, ZEB1, LIPA, STAT3, EPS15, RPS27, SYK, MKI67, YAP1, ZFP36L2, IFNAR2, NASP, CENPF, MRE11A, CDK7, HDGF, PLK1, BCAT1, EMP1, CSE1L, DLX5, CMC4, MTCP1, CD81, PTEN, TGFB2, RPL23A, GNB1, RAC1, PRKDC, H3F3A, DAB2, LRP2, CDK3, CDK5, NDP, IL9R, IL5RA, COL4A3, HHEX, PPARD, MXD1, PRDX1, ZFP36L1, KHDRBS1, BST2, EPS8, FOXC1, KLF10, SKP2, ILK, PDAP1, GAB1, SMAD4, PICALM, DCTN2, BOP1, TFDP1, GAS6, MELK, PDK1, PRKD1, ERBB4, ZMYND11, DLGAP5, STIL, MAPRE2, TGFBI, MAPRE1, UBE2V2, CTF1, FSCN1, IFI16, TXNRD1, CD276, BRAT1, LARP1, CSPG4, MCM10, PDPN, ASCC3, APPL2, POC1B, CSGALNACT1, PRG4, USP13, CUL5, ISG20, RHBDF1, DAZAP1, AURKB, NOX5, UHRF2, PURB, USP28, UHRF1, YME1L1, KIF2C, CITED1, CITED2, PELO, GNL3, DPH1, WDR12, BLZF1, FAM83D, NAA60, SRA1, TCF7L2, DUSP22, KIF15, PDS5B, PAK1IP1, DDIT4, ZAK, RRN3, EHF, PAK7, PEMT, CKLF, MORF4L1, VTI1B, DACH1, FBXL7, ELF5, TPX2, BOK, CDC14A, PA2G4, TCF19, TNFSF13B, SBDS, HDGFRP3, IRS2, LIPG, TACC3, LOC93622

GO:0008284

BP

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

CDC7, SDCBP, ADAM10, ITGB1BP1, EREG, BIRC5, HOXA3, TBX1, PRC1, GDF9, GREM1, DNAJA2, LRP5, CDC123, TNFSF13, CIAO1, FGF18, ALDH1A2, STAMBP, FGF19, TBC1D8, EGFR, F2, TIMP1, CST3, MYC, KRAS, PDGFB, TGFB1, CGA, FSHB, GHRH, INS, IGF2, FN1, PDGFA, S100B, GNAI2, IGF1, SLC25A5, IL6, EDN1, ITGB1, INSR, CCK, NPM1, ITGAV, CSF1R, LYN, THBS1, IGF1R, IL6R, NMB, FGF2, WNT2, PDGFRB, CTSH, AR, KIT, FGFR1, CDK4, ODC1, PTHLH, TDGF1, HGF, HCLS1, ETS1, LIF, RAC2, FOSL1, AREG, VEGFA, PDGFRA, EPCAM, XBP1, ATF3, EDN2, IL11, FGF7, FGFR2, TNFSF4, TNC, CDK2, CXCR2, ADRA1D, F2R, DPP4, CALR, MAPK1, CTGF, SERPINB3, CCND2, CDC25B, AVPR2, FGF9, CCKBR, TTK, GRK5, BTC, ADM, IRS1, FLT4, CHRNA7, TGFBR1, TGFBR2, COL18A1, IL6ST, PBX1, STAT3, HTR2B, AKR1C3, LIFR, CXCL5, PTGFR, SSR1, NAMPT, NOP2, CRKL, CDKN1B, NOTCH1, RPS9, YAP1, ID4, SOX9, DHPS, UBE2A, PGF, VEGFC, AGTR2, EFNB2, AKR1C2, MVD, PGGT1B, EMP2, NAP1L1, HDAC4, CD81, PTEN, ROMO1, TGFB2, RPS15A, EIF5A, SRPK2, ADAM17, PURA, MDM2, BNC1, NRG1, RELA, EGR4, PTK2, SOX4, FOXM1, CD47, CDC20, STX4, DLG1, TSPAN31, TIAM1, BAMBI, STX3, MAB21L1, ILK, TCIRG1, HDAC1, CUL3, CUL4A, RUNX2, CDK13, HES1, ZNF268, SUZ12, KIF14, ERBB4, FXN, CTF1, NTRK2, IL34, TSPYL5, CARM1, CACUL1, CCAR1, GCNT2, SFRP1, DBF4B, GADD45GIP1, TRPM4, PHIP, HDAC2, PROX1, HAS2, TBRG4, NUDT16, VWCE, CDCA7L, KIF20B, HBEGF, S1PR3, GPER1, S100A13, OSMR, CIB1, PDCD10, TIPIN, SSBP3, PDGFD, DERL2, EIF5A2, HIPK2, GAREM1, CD248, ESM1, CLCF1, ASH2L, CNOT7, CCPG1, CNOT6, APLN, FZR1, TNFSF13B, IRS2, HILPDA, TNFRSF11A

GO:0008285

BP

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

PLPP1, PTGES, ITGB1BP1, PDCD5, IRF6, TAX1BP3, EREG, MDM4, CYP27B1, TGFB1I1, EEF1E1, KLF4, SMAD6, SPRY2, SPRY1, TLR2, JAK2, SKAP2, PRKRA, UTP20, ALDH1A2, GDF11, PLG, TGFB1, GNRH1, IL1A, IL1B, FTH1, RAF1, SOD2, NTRK1, TP53, IL6, JUN, FABP3, NPM1, SERPINE2, CSF1R, LYN, INHBA, CXCL1, GLI3, CXCL8, AR, IRF1, VDR, PTHLH, BMP2, BMP4, SKI, IFITM1, DRD2, ETS1, LIF, B4GALT1, FOSL1, NME1, TIMP2, HMGA1, PTPN2, IGFBP3, WT1, CD33, CD9, IL10, IGFBP6, APC, F2R, AZGP1, TNFRSF8, NOS3, ADORA1, SSTR1, S100A11, CDH5, CTNNB1, PHB, NF2, ADM, SSTR5, ADRA1A, PTGS2, NUP62, ZEB1, CDKN1A, COL18A1, STAT3, BCL6, CSK, CDKN2B, CDKN2C, CDKN1B, NOTCH1, VEGFC, RARRES1, TSC2, MXI1, FABP6, SMARCA2, RBM5, EMP3, CDH13, HDAC4, CTBP2, PTEN, TGFB2, BTG1, BTG2, ADARB1, GPLD1, FOXO4, CDK6, HSF1, INSM1, PMP22, COL4A3, MAP2K1, NOTCH2, CD164, ZBTB16, SOX4, DDR1, RBBP4, PTPRJ, STK4, KLF10, PPP2R5C, SMAD4, HDAC1, PKD2, CUL2, CUL4A, TOB2, MXD4, ZNF268, GPNMB, CDK10, PTPRK, ERBB4, RPS6KA2, DHCR24, KISS1, SMAD2, SMAD1, STK11, IGFBP7, CDKN3, CYP1B1, TBRG1, SFRP5, TNS2, KANK2, SFRP4, NRK, PODN, PBRM1, MAGI2, P3H2, CHERP, SIRT2, LAS2, ABI1, SFRP1, DLG5, RASSF5, BAP1, NDRG1, PROX1, KAT2B, KIFAP3, CUL5, HIST1H2AC, TP53INP1, RERG, ZNF503, DLC1, GPER1, MNT, COPS8, CDC6, CIB1, PKP2, FOXP3, RGCC, NOX4, BRD7, DLL4, PDS5B, SH3BP4, PEMT, TES, DDX20, ADAMTS1, CNOT7, ADAMTS8, KLF13, ADGRG1

GO:0008286

BP

insulin receptor signaling pathway

The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.

PIK3C2A, IRS4, ATP6V0E1, ATP6V1G1, ATP6V1G2, INS, IGF2, INSR, IGF1R, IGFBP1, IDE, RHOQ, PTPN2, ATP6V1B2, ATP6V1C1, PIK3R1, AKT1, AKT2, IRS1, SREBF1, CAV2, ATP6V0D1, GRB2, GPLD1, FOXO4, SOS1, FOXO1, GAB1, TCIRG1, EIF4EBP1, EIF4EBP2, PDK4, ATP6V1F, ATP6V1C2, PHIP, SMARCC1, ATP6V0A1, SORBS1, KL, BAIAP2L1, ATP6V1H, IRS2, ATP6V1D

GO:0008295

BP

spermidine biosynthetic process

The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.

AMD1, SRM, AGMAT

GO:0008298

BP

intracellular mRNA localization

Any process in which mRNA is transported to, or maintained in, a specific location within the cell.

BICD1

GO:0008299

BP

isoprenoid biosynthetic process

The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.

HMGCR, FDFT1, MVD, HMGCS1, MVK, IDI1, PDSS1, PDSS2, COQ2, IDI2

GO:0008306

BP

associative learning

Learning by associating a stimulus (the cause) with a particular outcome (the effect).

DRD2, GABRA5, CHRNA7, NPTX2, PPT1, SNAP25, BTG2, CLN3, TNR

GO:0008333

BP

endosome to lysosome transport

The directed movement of substances from endosomes to lysosomes.

DENND3, SNAPIN, ADRB2, RAB7A, VAMP7, SNX16, RHOB, MTM1, RAB12, HOOK3, HOOK2, AKTIP, HMGXB4, TRAK1

GO:0008334

BP

histone mRNA metabolic process

The chemical reactions and pathways involving an mRNA encoding a histone.

SSB, SNRPB, SNRPF, SNRPD3, NCBP1, SLBP

GO:0008340

BP

determination of adult lifespan

The control of viability and duration in the adult phase of the life-cycle.

TP53, IDE, MSH2, MSH6, PRDM2, RAD54L, INPP5D

GO:0008343

BP

adult feeding behavior

Feeding behavior in a fully developed and mature organism.

AGRP, LEP, USP46, CARTPT, GHSR, GHRL

GO:0008344

BP

adult locomotory behavior

Locomotory behavior in a fully developed and mature organism.

CHL1, PARK2, CSTB, APP, CNP, TMOD1, HOXD10, SNCA, NR4A2, CXCL12, ARCN1, PPT1, ATP1A2, FGF12, ID2, EPS8, PUM1, GIGYF2, PREX2, BTBD9

GO:0008347

BP

glial cell migration

The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.

MATN2, TSPO, EPHA4, TGFB2, CSPG4

GO:0008354

BP

germ cell migration

The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.

PLPP1, PLPP3, TGFB1, ITGB1, KIT, TGFBR1, CXADR, FOXC1

GO:0008355

BP

olfactory learning

Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.

ADCY3

GO:0008356

BP

asymmetric cell division

The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.

ACTR3, ACTR2, GOLGA2, PARD3

GO:0008360

BP

regulation of cell shape

Any process that modulates the surface configuration of a cell.

WIPF3, CDC7, PLXNB2, SEMA3E, DAPK3, COCH, C21orf2, PRPF40A, F2, FN1, ALDOA, ANXA1, S100B, ITGB2, IL6, ICAM1, FYN, CSF1R, TPM1, FGR, CCL3, KIT, CCL2, EZR, VEGFA, RHOQ, RASA1, CORO1A, RDX, MYH9, CSNK1A1, CSNK1D, CSNK1E, GNA12, PTK2, EPS8, DLG1, BAMBI, PLEKHO1, BRWD3, FGD6, RHOU, CYFIP1, FGD2, PDPN, PALM2, ARHGAP18, BVES, SHROOM3, FBLIM1, ARAP3, PHIP, FGD4, ARAP1, DLC1, S100A13, VRK1, SEMA4A, RHOJ, CSNK1G1, MYO10, CDC42SE2, CDC42SE1, BRWD1, PARVA, TBCCD1, CFDP1, LIMD1, CDC42EP3, TAOK2, MKLN1, EPB41L3, CSNK1G3

GO:0008361

BP

regulation of cell size

Any process that modulates the size of a cell.

VAV1, CREB1, IL7R, RDX, RAC1, IQGAP3, VAV3

GO:0008366

BP

axon ensheathment

Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.

PLP1, NRG1, POU3F1, PPARD

GO:0008380

BP

RNA splicing

The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

SAP18, DHX15, RBFOX2, PRPF3, DHX16, SYNCRIP, NOL3, ZPR1, ZRANB2, LUC7L3, PTBP3, HNRNPC, SNRPA1, SNRPB, LGALS3, SON, WT1, SFPQ, PTBP1, PPP2R1A, HNRNPH3, RBM25, NOVA1, AFF2, SNRPF, LSM6, SNRPD1, SNRPD2, SNRPD3, SNRPN, SRPK2, SRSF2, SRSF11, FMR1, C1QBP, NCBP1, SF3A3, TARDBP, PPIG, PRPF4B, RBM39, ZNF638, WTAP, NONO, RNPS1, SNRNP35, ZNF326, MBNL2, ARL6IP4, THOC7, JMJD6, SUPT6H, SUGP2, SRRM1, CCAR2, SREK1IP1, THOC2, RP9, ZCRB1, SREK1, KHSRP, SNRNP40, RSRC1, THOC3, RNPC3, QKI, SRPK1, SCAF11, PRPF18, RBM4B, DDX23, SNRNP25, RBM4, DDX47, RBM38, RRAGC, MBNL1, MBNL3, RBFOX1, CDK12, PPARGC1A, PUF60, TTF2, SCAF8, THRAP3, LSM4, IVNS1ABP

GO:0008406

BP

gonad development

The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.

WT1, FSHR, NR0B1, RDH10, OSR1, MKKS

GO:0008535

BP

respiratory chain complex IV assembly

The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms.

METTL17, COX11

GO:0008542

BP

visual learning

Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.

KRAS, HMGCR, APP, ITGB1, KIT, DRD2, CREB1, HRH1, ATP1A2, CDK5, GRIN2A, HIF1A, SYNGAP1, NDRG4