GO:0010830

BP

regulation of myotube differentiation

Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

SIK1, DMPK, RBM24, RBM38, HDAC5

GO:0010831

BP

positive regulation of myotube differentiation

Any process that increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

THRA, MMP14, MAPK14

GO:0010832

BP

negative regulation of myotube differentiation

Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

XBP1, NOTCH1, HDAC4, HDAC5

GO:0010833

BP

telomere maintenance via telomere lengthening

Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA.

RAD51, OBFC1

GO:0010835

BP

regulation of protein ADP-ribosylation

Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.

PUM3, KAT2B

GO:0010837

BP

regulation of keratinocyte proliferation

Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.

ZFP36, YAP1, ZFP36L1, SRSF6, PRKD1

GO:0010838

BP

positive regulation of keratinocyte proliferation

Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.

FGF7, HAS2

GO:0010839

BP

negative regulation of keratinocyte proliferation

Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.

CASK, SNAI2, VDR, SFN, EFNB2, KLF9, PTPRK, INTU

GO:0010841

BP

positive regulation of circadian sleep/wake cycle, wakefulness

Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep.

NLGN1

GO:0010842

BP

retina layer formation

The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.

TSPAN12, PTPRM, SDK2, SDK1, FJX1, AHI1, RDH13, HIPK2

GO:0010845

BP

positive regulation of reciprocal meiotic recombination

Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.

UBE2B

GO:0010847

BP

regulation of chromatin assembly

Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus.

SPTY2D1

GO:0010849

BP

regulation of proton-transporting ATPase activity, rotational mechanism

Any process that modulates the rate of ATP hydrolysis by an ATPase. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

PPIF

GO:0010862

BP

positive regulation of pathway-restricted SMAD protein phosphorylation

Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

SDCBP, MSTN, GDF9, GDF11, BMP10, BMP15, TGFB1, INHA, INHBA, INHBB, BMP2, BMP4, BMP3, BMP1, BMP6, ACVR2A, TTK, BMP8B, BMPR1A, ACVR1B, TGFBR1, GDF5, INHBC, TGFB2, DAB2, ACVR1, SMAD4, BMPR2, HFE, BMP8A, RBPMS, GDF15

GO:0010863

BP

positive regulation of phospholipase C activity

Any process that increases the rate of phospholipase C activity.

ESR1, FGF2, PDGFRB, KIT, FGFR1, PDGFRA, PTAFR, ABL2

GO:0010866

BP

regulation of triglyceride biosynthetic process

Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.

C3

GO:0010867

BP

positive regulation of triglyceride biosynthetic process

Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.

CTDNEP1, LDLR, SREBF1, NR1H2, GPLD1, PLIN5, NR1H3, RGN, CNEP1R1, SCARB1, DGAT2

GO:0010868

BP

negative regulation of triglyceride biosynthetic process

Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.

SIK1

GO:0010870

BP

positive regulation of receptor biosynthetic process

Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

EDN1, NR1H3, HDAC1, HIF1A, HDAC2, HDAC6

GO:0010871

BP

negative regulation of receptor biosynthetic process

Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

NR1D1, PPARG, PPARA

GO:0010872

BP

regulation of cholesterol esterification

Any process that modulates the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.

LAMTOR1

GO:0010873

BP

positive regulation of cholesterol esterification

Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.

AGT, APOA1, APOE, APOA2, APOC1, AGTR1, APOA5, STARD4

GO:0010874

BP

regulation of cholesterol efflux

Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.

LAMTOR1

GO:0010875

BP

positive regulation of cholesterol efflux

Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.

ABCA1, APOE, PON1, NR1H2, NR1H3, PTCH1, ADIPOQ

GO:0010877

BP

lipid transport involved in lipid storage

The directed movement of lipids into cells that is part of their accumulation and maintenance.

APOE

GO:0010878

BP

cholesterol storage

The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

SOAT1

GO:0010879

BP

cholesterol transport involved in cholesterol storage

The directed movement of cholesterol into cells that is part of their accumulation and maintenance.

STARD4

GO:0010880

BP

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.

DMD, GSTM2, SRI, CALM2, GSTO1, PDE4D, AKAP6, CAMK2D, CHD7

GO:0010881

BP

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.

DMD, PRKACA, PLN, GSTM2, ATP1A2, CALM2, GSTO1, ANK2, CAMK2D, CACNA1C, RYR2

GO:0010882

BP

regulation of cardiac muscle contraction by calcium ion signaling

Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction.

ATP1B1, ATP2A2, HDAC4, ANK2, RYR2

GO:0010883

BP

regulation of lipid storage

Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.

MEST, ALKBH7, FTO

GO:0010884

BP

positive regulation of lipid storage

Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.

ACACB, C3, APOB, NFKB1, NR1H2, PLIN5, HILPDA

GO:0010886

BP

positive regulation of cholesterol storage

Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

APOB, LPL, CD36, SREBF2, SCARB1

GO:0010887

BP

negative regulation of cholesterol storage

Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

ABCA1, PPARG, NR1H2, PPARA, NR1H3

GO:0010888

BP

negative regulation of lipid storage

Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.

TNF, CRP, ITGB3, IL6, ITGAV, PTPN2, LEP

GO:0010890

BP

positive regulation of sequestering of triglyceride

Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.

LPL, PLIN5, OSBPL11

GO:0010891

BP

negative regulation of sequestering of triglyceride

Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.

PPARG, PPARA, ABHD5, PNPLA2, OSBPL8

GO:0010894

BP

negative regulation of steroid biosynthetic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

INSIG1, BMP2

GO:0010897

BP

negative regulation of triglyceride catabolic process

Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.

APOC3, PIK3CG, GPLD1, PLIN5

GO:0010898

BP

positive regulation of triglyceride catabolic process

Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.

APOA1, AADAC, APOA5, ABHD5, PNPLA2

GO:0010899

BP

regulation of phosphatidylcholine catabolic process

Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

LDLR, SCARB1

GO:0010900

BP

negative regulation of phosphatidylcholine catabolic process

Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

APOC1

GO:0010902

BP

positive regulation of very-low-density lipoprotein particle remodeling

Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid.

APOA5

GO:0010903

BP

negative regulation of very-low-density lipoprotein particle remodeling

Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid.

APOA1, APOA2, APOC3

GO:0010906

BP

regulation of glucose metabolic process

Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.

ACACB, PARK2, IGFBP3, IGFBP4, IGFBP5, RORA, PDK1, NCOA2, ADIPOQ, PDK4, ADIPOR1, PASK, C1QTNF1, LCMT1, SIK3

GO:0010907

BP

positive regulation of glucose metabolic process

Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.

AKT1, AKT2, IRS1, GPLD1, PMAIP1, RGN, IRS2

GO:0010909

BP

positive regulation of heparan sulfate proteoglycan biosynthetic process

Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues.

CTNNB1, PXYLP1, TCF7L2

GO:0010916

BP

negative regulation of very-low-density lipoprotein particle clearance

Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

APOC1, APOC3, LRPAP1

GO:0010917

BP

negative regulation of mitochondrial membrane potential

Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

ARL6IP5, PMAIP1, PRELID1, HEBP2

GO:0010918

BP

positive regulation of mitochondrial membrane potential

Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

VCP, BAD

GO:0010922

BP

positive regulation of phosphatase activity

Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.

BMP2, RGN

GO:0010923

BP

negative regulation of phosphatase activity

Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.

URI1, MYO1D, CD2BP2, RRP1B, TMEM132D, RBM26, ARFGEF3, CNST, SPOCD1, SPRED1, ZCCHC9, CASC5, PPP1R35, SH3RF2, CSRNP3, PKMYT1, CHP1, NIFK, CCDC8, CSRNP2, WNK1, PCIF1, ZFYVE1, SYTL2, GPATCH2, CAMSAP3, TSKS, FARP1, KIAA0430

GO:0010933

BP

positive regulation of macrophage tolerance induction

Any process that increases the frequency, rate, or extent of B cell tolerance induction.

IRAK3

GO:0010934

BP

macrophage cytokine production

The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

GAS6

GO:0010936

BP

negative regulation of macrophage cytokine production

Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

TGFB1, TGFB2, IRAK3

GO:0010939

BP

regulation of necrotic cell death

Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.

UBC, PPIF, RPS27A, UBA52, BIRC3, RIPK1, CASP8, TRADD

GO:0010940

BP

positive regulation of necrotic cell death

Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.

MT3, TSPO, RIPK1, HEBP2

GO:0010941

BP

regulation of cell death

Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

CRYAB, JUN, JUNB, JUND

GO:0010942

BP

positive regulation of cell death

Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

PRODH, TRIM13, HP, MYCN, BMP4, MT3, PHB, AKR1C3, CDKN1B, UCP2, HBB, HBA1, KATNB1, SAP30BP, FAF1

GO:0010944

BP

negative regulation of transcription by competitive promoter binding

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site.

SMAD7, MUC1, CREB1, PHB, HHEX, DACH1

GO:0010948

BP

negative regulation of cell cycle process

Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

GPER1

GO:0010949

BP

negative regulation of intestinal phytosterol absorption

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine.

ABCG8

GO:0010950

BP

positive regulation of endopeptidase activity

Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

SERPINB3, PSME3, ADRM1, PRELID1

GO:0010951

BP

negative regulation of endopeptidase activity

Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

SPINT2, PAPLN, PTTG1, SERPINC1, SERPINA1, SERPINA3, AGT, A2M, C3, TIMP1, CSTA, KNG1, AMBP, AHSG, SLPI, VTN, CSTB, APP, SERPINE1, SERPINA5, SERPING1, SERPINE2, FURIN, C4A, C4B, TFPI, COL6A3, TIMP2, CAST, ANOS1, SERPINB3, PEBP1, SERPINB1, AKT1, SERPINB5, SERPINF1, TFPI2, SERPINB4, SERPINB9, SERPINH1, COL4A3, APLP2, BST2, SPP2, WFDC2, CARD16, ITIH5, WFDC3, SERPINA12, CPAMD8, SPOCK2, SERPINI1, PROL1, SPOCK3, LXN, WFDC1, CRIM1, FETUB, SERPINB13, UCHL5

GO:0010952

BP

positive regulation of peptidase activity

Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.

CLPX, FN1, APP, CTSH, FBLN1, MMP14, CAV1, PSME4, PCOLCE, PINK1, NDUFA13, PCOLCE2

GO:0010954

BP

positive regulation of protein processing

Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.

ADAM8, CCBE1, RHBDD1

GO:0010955

BP

negative regulation of protein processing

Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage.

SERPINE2, IL1R2, GAS1, MDM2, GLG1, CHAC1, TMEM59, SNX12

GO:0010956

BP

negative regulation of calcidiol 1-monooxygenase activity

Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.

CYP27B1, NFKB1

GO:0010957

BP

negative regulation of vitamin D biosynthetic process

Any process that decreases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).

SNAI2, NFKB1

GO:0010960

BP

magnesium ion homeostasis

Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell.

EGFR, KCNA1, ANK3, CNNM2

GO:0010961

BP

cellular magnesium ion homeostasis

Any process involved in the maintenance of an internal steady state of magnesium ions at the level of a cell.

TRPM7

GO:0010965

BP

regulation of mitotic sister chromatid separation

Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis.

TPR

GO:0010968

BP

regulation of microtubule nucleation

Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.

EML2

GO:0010970

BP

transport along microtubule

The movement of organelles or other particles from one location in the cell to another along microtubules.

DCTN1

GO:0010971

BP

positive regulation of G2/M transition of mitotic cell cycle

Any process that increases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.

CDC7, RAD51C, BRD4, VPS4B, APP, CDK4, PBX1, RAB11A, SMARCD3, DBF4B

GO:0010972

BP

negative regulation of G2/M transition of mitotic cell cycle

Any cell cycle regulatory process that decreases the rate or extent of progression of a cell from G2 to M phase of the mitotic cell cycle.

FHL1

GO:0010975

BP

regulation of neuron projection development

Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

AKT1, PTEN, SNAP25, NCS1, CCDC88A, SFRP1, ULK4, NDEL1, CHODL

GO:0010976

BP

positive regulation of neuron projection development

Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

APBB1, ENC1, PLXNB2, CBFA2T2, KDM1A, SNX3, NTRK1, IL6, FYN, LYN, FGFR1, NME1, ARSB, ATF1, CNR1, NME2, ITGA3, EPHA3, LTK, SERPINF1, WNT5A, PRKCI, ABL2, RAP1A, CNTN1, PTK7, RAPGEF1, CAMK1, SCARF1, DPYSL3, PRKD1, PPP2R5B, ANKRD1, UBE2V2, NTRK2, TWF2, FBXO38, FAM150B, SETX, MAGI2, CAMK1D, NDNF, FEZ1, KATNB1, TMEM30A, RRN3, GPRC5B, TENM3, KIDINS220, NDRG4

GO:0010977

BP

negative regulation of neuron projection development

Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

RAB29, CBFA2T2, SNAPIN, NGFR, VIM, LGALS1, NR2F1, PTPRG, GSK3B, B2M, MDM2, PMP22, FKBP4, DPYSL3, SEMA3A, KANK1, PTPRO, DGUOK, HDAC2, CIB1, TRPV4, BAG5

GO:0010980

BP

positive regulation of vitamin D 24-hydroxylase activity

Any process that increases the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D.

CYP27B1, VDR

GO:0010983

BP

positive regulation of high-density lipoprotein particle clearance

Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

GPLD1, LIPG

GO:0010987

BP

negative regulation of high-density lipoprotein particle clearance

Any process that decreases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

APOC3

GO:0010988

BP

regulation of low-density lipoprotein particle clearance

Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

NR1H4, CNPY2

GO:0010989

BP

negative regulation of low-density lipoprotein particle clearance

Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

APOC3, CSK, PCSK9, MYLIP

GO:0010990

BP

regulation of SMAD protein complex assembly

Any process that modulates the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins.

PARP1

GO:0010991

BP

negative regulation of SMAD protein complex assembly

Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins.

SMAD6, PMEPA1

GO:0010992

BP

ubiquitin homeostasis

Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell.

IDE

GO:0010994

BP

free ubiquitin chain polymerization

The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein.

UBE2C, PARK2, UBE2S, TRIM6

GO:0010996

BP

response to auditory stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus.

IL6, XPA, XPC, ABHD12

GO:0010998

BP

regulation of translational initiation by eIF2 alpha phosphorylation

Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.

EIF2AK4

GO:0012501

BP

programmed cell death

A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.

TOP1, PKM, RNF130, GSDMB

GO:0014002

BP

astrocyte development

The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.

TLR4, TSPAN2, S100A8, S100A9, VIM, MT3, PLP1, CDK6, EIF2B5, LAMC3

GO:0014003

BP

oligodendrocyte development

The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.

TGFB1, LYN, GSTP1, CD9, ASCL1, ID2, EIF2B5, EIF2B1, MED12, EIF2B3, EIF2B4, MYRF

GO:0014005

BP

microglia development

The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

TSPAN2

GO:0014009

BP

glial cell proliferation

The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.

PENK, EEF2, AREG, SOX4

GO:0014010

BP

Schwann cell proliferation

The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.

NF2

GO:0014012

BP

peripheral nervous system axon regeneration

The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury.

APOA1, APOD, TNC, TSPO

GO:0014013

BP

regulation of gliogenesis

Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia.

NF2, EZH2

GO:0014015

BP

positive regulation of gliogenesis

Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia.

SOX8

GO:0014028

BP

notochord formation

The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.

EFNA1