GO:0000015

CC

phosphopyruvate hydratase complex

A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water.

ENO1, ENO2, ENO3

GO:0000109

CC

nucleotide-excision repair complex

Any complex formed of proteins that act in nucleotide-excision repair.

ERCC1, POLD1, ERCC4

GO:0000110

CC

nucleotide-excision repair factor 1 complex

One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively.

ERCC1, XPA, ERCC4

GO:0000111

CC

nucleotide-excision repair factor 2 complex

One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p.

XPC

GO:0000118

CC

histone deacetylase complex

A protein complex that possesses histone deacetylase activity.

SAP18, HDAC3, TBL1X, ZNF217, NCOR1, TAL1, CBX5, NRIP1, HINT1, HDAC4, HDAC1, HDAC7, HDAC8, TBL1XR1, DNTTIP1, RERE, HDAC6, HDAC9, HDAC5, NCOR2

GO:0000120

CC

RNA polymerase I transcription factor complex

A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I.

CD3EAP, TAF1C, TAF1A

GO:0000123

CC

histone acetyltransferase complex

A protein complex that possesses histone acetyltransferase activity.

OGT, IKBKAP, EP300, JADE1, JADE3, CREBBP, ELP4, PHF20, ELP3, KANSL3

GO:0000124

CC

SAGA complex

A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.

USP27X, SUPT3H, TADA3, USP34, USP51, TAF9B, ENY2, USP22

GO:0000125

CC

PCAF complex

A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.

TADA2A, TAF10, KAT2B, TRRAP

GO:0000127

CC

transcription factor TFIIIC complex

A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.

GTF3C2, GTF3C4

GO:0000137

CC

Golgi cis cisterna

The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.

GOLGA2, NECAB3, TMEM59

GO:0000138

CC

Golgi trans cisterna

The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.

B4GALT1, SGMS1, HID1, TMEM59

GO:0000139

CC

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

GPR89A, SLC33A1, GOLIM4, EBAG9, PPP6C, COPE, AP3D1, GOSR2, ANKRD28, LEPROT, SURF4, GRM6, TLR3, B4GALT5, B4GAT1, KDELR3, CYTH3, STX6, B3GALT2, HS6ST1, TPST1, B4GALT4, TPST2, FAM20B, ENTPD6, VAMP4, SEC22B, AP1G2, TRAPPC6A, SEC24D, SEC31A, CLSTN1, CSPG5, TNKS, VAPB, SNAPIN, LARGE, SNAP29, B3GALT4, F8, EGFR, SERPINA1, NRAS, PDGFB, TGFA, INS, HLA-B, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, PDGFA, CD74, CYP2E1, CD55, FURIN, GPR89B, TRAPPC2, SRGN, SLC2A1, F5, NCAM1, HLA-E, HLA-DRB4, B4GALT1, FOLR1, AREG, ST6GAL1, GJA1, HLA-G, ATF6, HLA-DPA1, OSBP, FUT4, KDELR1, NOS3, HLA-A, HLA-F, GBP1, GBP2, MAN1A1, BSG, TRIM23, SREBF1, IFNGR2, PRKCI, NSG1, NSF, NOTCH1, ARCN1, TRAPPC10, CSNK1D, PITPNB, MAN2A2, TMED10, PSEN1, PSEN2, CAV2, CLCN3, CLCN5, NDST1, ARFIP1, COPA, CTSC, EMP2, SEC13, AP1S2, GABARAPL2, CDC42, RAB2A, ST8SIA6, B2M, COPZ1, AP1S1, RAB1A, RAC1, SLC35A2, SLC35A1, HLA-DRB3, TMF1, ARF1, PKD1, ATP2C1, CAV1, NOTCH2, ICA1, GOLGA2, MGAT2, GALNT2, GALNT1, AP1B1, ST3GAL1, ST3GAL3, ST3GAL4, SREBF2, HYAL2, MALL, CLN3, PLD1, GOLGA4, SERINC3, CUL3, CUX1, COG2, TMED2, RHEB, DHCR24, SEC23A, TRIP11, EXT1, UGCG, ST3GAL2, TMEM132A, HLA-DRB5, GNPTAB, MGAT5B, KLHL12, WIPI1, MANEA, ARHGAP21, WLS, STEAP4, RAB12, RHBDD2, AGTRAP, PARM1, C6orf89, B3GNT9, CHSY3, SLC35D2, RHOU, LPCAT2, CHST15, HS2ST1, CHST3, GALNT5, GALNT7, GALNT10, SGMS1, CHSY1, GPSM1, ERC1, ZDHHC17, TRAPPC5, HACE1, KIAA0319L, DSEL, GCNT2, GALNT15, GALNT4, ARFGAP2, CHST4, B3GNT7, SVIP, MCFD2, TMEM167A, CSGALNACT1, PXYLP1, RAB2B, ABCA5, ST8SIA4, GBF1, TFG, GLG1, EXT2, PMEPA1, ERGIC1, RHBDF1, OPTN, GALNT14, PGAP3, SEC16B, ST6GAL2, HS6ST2, GPER1, MPHOSPH9, PKMYT1, CHP1, SH3GL2, SLC35A5, NDFIP1, PDCD10, APOO, ST6GALNAC5, TAPBPL, TMEM59, FUT8, B3GNT5, PDGFD, CHST5, CHST6, GBP3, RAB1B, LMAN2L, XYLT2, BLZF1, TNKS2, ACBD3, CLSTN2, ST6GALNAC4, GLIPR2, NAA60, RNF121, FKRP, GBA2, GOPC, ABCB6, ARFGAP3, PNPLA8, CHST11, MAN1C1, PDGFC, RAB6B, AGPAT3, CHST7, NDFIP2, SYBU, SMPD4, ZDHHC7, B3GNT2, BET1L, VAPA, PI4KB, CTSZ, B4GALT6, SCOC, ST6GALNAC2, GNPTG, DSE, TMCO1, MGAT4A, BOK, PPP6R1, MAPK8IP3, MGAT4B, RNF24, ST3GAL6, ITM2B, SLC35A3, PIKFYVE, COG6, SH3GLB1, GOLT1B, TMED3, CHST2, TRAPPC1, HS3ST3B1, COPG1, ARFGEF2

GO:0000145

CC

exocyst

A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.

WASH1, EXOC5, EXOC3, RALB, TNFAIP2, SEPT2, MYRIP, STXBP6, EXOC4, EXOC2, EXOC1, EXOC7

GO:0000151

CC

ubiquitin ligase complex

A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

ASB14, WWP2, GPR37, MED7, PARK2, FBXO24, RNF8, UBE4B, HSPA1A, HSPA1B, DNAJA1, BRCA1, BRCC3, RNF144A, UBE2E1, UBE2V1, MED21, RNF19B, UBR3, CBLL1, RNF144B, CAND1, UBR1, UBE2J2, FBXO25, DCUN1D4, DYRK2, MED12, MIB2, DCUN1D1, MED30, GMCL1, ASB16, MPHOSPH8, BARD1, PINK1, WWP1, MED20, SMURF2, FBXO8, RNF19A, MED17, RNF216, RNF14, FBXL7, FBXO10, FBXO9, STUB1, SUGT1, ARIH1, ASB3

GO:0000152

CC

nuclear ubiquitin ligase complex

A ubiquitin ligase complex found in the nucleus.

BRCC3

GO:0000159

CC

protein phosphatase type 2A complex

A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.

PPP2R1A, PPP2CB, CYCS, PPP2R3A, STRN3, PPP2R5C, PPP2R5D, PPP2R5A, PPP2R5B, PPP2R4, STRN4

GO:0000164

CC

protein phosphatase type 1 complex

A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.

PPP1R11, PPP1R15A, PPP1R2, PPP1CA, PPP1CB, PPP1R3B

GO:0000172

CC

ribonuclease MRP complex

A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.

POP4

GO:0000176

CC

nuclear exosome (RNase complex)

A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.

EXOSC9, EXOSC2, C1D, EXOSC7, EXOSC6, EXOSC8, EXOSC4, EXOSC3, DIS3

GO:0000177

CC

cytoplasmic exosome (RNase complex)

A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.

EXOSC9, EXOSC2, EXOSC7, EXOSC6, EXOSC8, EXOSC4, EXOSC3, DIS3, CARHSP1

GO:0000178

CC

exosome (RNase complex)

A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.

SKIV2L2, EXOSC9, EXOSC2, EXOSC7, EXOSC6, KHSRP, EXOSC8, EXOSC4, EXOSC3, DIS3

GO:0000220

CC

vacuolar proton-transporting V-type ATPase, V0 domain

The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.

TCIRG1, ATP6V0A1

GO:0000221

CC

vacuolar proton-transporting V-type ATPase, V1 domain

The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.

ATP6V1H

GO:0000228

CC

nuclear chromosome

A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.

BIRC5, H2AFY, SMC2, ZBED1, JUN, TOP1, TOP2A, MSH3, MSH6, HMGA2, BLM, HIST1H4A, HIST1H3D, H3F3A, EXOSC9, RAD51, SPIDR, NCAPD2, SETX, PBRM1, HDAC8

GO:0000235

CC

astral microtubule

Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.

MAP9, KIF18B

GO:0000242

CC

pericentriolar material

A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.

CEP152, TNKS, TCP1, TUBG1, PCM1, HOOK3, NIN, NEK1, TNKS2, TUBE1

GO:0000243

CC

commitment complex

A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript.

SNRPC, SNRPD1, SNRPD3, SNRNP35, PRPF39

GO:0000274

CC

mitochondrial proton-transporting ATP synthase, stator stalk

One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core.

ATP5H

GO:0000275

CC

mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)

The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled.

ATP5D, ATP5C1, ATP5E

GO:0000276

CC

mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins.

ATP5L, ATP5J, ATP5G3, ATP5I, ATP5G2

GO:0000307

CC

cyclin-dependent protein kinase holoenzyme complex

Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.

CDK4, CDK2, CCND2, CCND3, CKS2, CDKN1A, CKS1B, CDK6, CCNL2, CCNL1

GO:0000322

CC

storage vacuole

A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.

CDC42, STX4, ARHGEF7

GO:0000346

CC

transcription export complex

The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.

ZC3H11A, SARNP, THOC7, ALYREF, THOC2, THOC3, POLDIP3, NXF1

GO:0000347

CC

THO complex

The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.

THOC7, THOC2

GO:0000407

CC

pre-autophagosomal structure

A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes.

ATG13, SQSTM1, NBR1, WIPI1, ATG2B, VMP1, ZFYVE1, WIPI2

GO:0000408

CC

EKC/KEOPS complex

A protein complex involved in t6A tRNA modification; originally proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p.

TP53RK

GO:0000421

CC

autophagosome membrane

The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.

SNAP29, RAB7A, GABARAPL2, CALCOCO2, WIPI1, TECPR1, ATG16L2, VMP1, MAP1LC3B, GABARAPL1, MAP1LC3A, SH3GLB1

GO:0000439

CC

core TFIIH complex

The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD.

ERCC2, GTF2H1, GTF2H2, GTF2H2C_2, GTF2H4

GO:0000444

CC

MIS12/MIND type complex

A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1.

NSL1, DSN1

GO:0000445

CC

THO complex part of transcription export complex

The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.

THOC7, THOC2, THOC3

GO:0000446

CC

nucleoplasmic THO complex

The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits.

THOC7

GO:0000502

CC

proteasome complex

A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.

PSMD11, PSMD12, PSMD3, PSMD10, HSPB1, PSMC3, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, PSMC2, PSMB10, PSMC4, PSMB3, PSMD7, RAD23A, RAD23B, VCP, SHFM1, PSME3, PSMC1, PSMC6, PSMD2, UBE3C, ADRM1, UBR1, PAAF1, PSMG3

GO:0000506

CC

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast.

PIGA, PIGH, PIGY, PIGC

GO:0000775

CC

chromosome, centromeric region

The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

NDC80, BIRC5, OIP5, RAD21, TNKS, CENPB, PPP2R1A, MKI67, CENPA, CENPF, PPP2CB, CBX1, CENPE, FMR1, CBX3, PPP2R5C, SMC1A, PPP2R5A, PDS5A, CDCA8, SGOL2, CENPW, SGOL1, CENPQ, WAPL, CENPL, HJURP, NGDN, CDCA5, KIF2C, DSCC1, NUF2, SUV39H2, HELLS, PDS5B, MIS18A, SMC3, ZNF330

GO:0000776

CC

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

DYNC1I1, NDC80, PPP1R12A, XPO1, ZNF207, BUB1, BUB3, BUB1B, ZWINT, TPR, APC, CLIP1, CBX5, RANGAP1, CENPF, PSEN1, PSEN2, NEK2, PLK1, SEC13, SUMO3, NUP107, DYNLL1, CENPE, CENPC, NUP160, MAD2L1, DCTN2, CKAP5, DCTN1, SMC1A, KIF22, CENPW, SGOL1, CENPV, TEX14, SKA3, ZNF276, NUP43, NUP37, KIF18A, KAT2B, ANAPC16, SEH1L, AURKB, SPAG5, KIF2C, NUP85, NDEL1, CENPH, ZWILCH, MEAF6, NDE1, LRWD1, SUGT1, KNSTRN, MAD1L1

GO:0000777

CC

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

STRA13, DCTN6, DYNC1I1, NDC80, BIRC5, ZNF207, BUB1, BUB3, BUB1B, ZWINT, PPP1CC, RANGAP1, CSNK1A1, KNTC1, NEK2, NUP107, CENPC, MAD2L1, ITGB3BP, SEPT6, SMC1A, SEPT2, SEPT7, ERCC6L, SGOL2, CENPW, SGOL1, CENPU, CENPV, TEX14, APITD1, ZNF276, SPC24, HJURP, NUP43, NUP37, CASC5, NUDCD2, AHCTF1, ANAPC16, SEH1L, CENPN, BOD1, CHAMP1, SPAG5, KIF2C, CENPK, DCTN5, CENPO, NUP85, NUF2, NDEL1, CENPH, ZWILCH, MEAF6, SPC25, CENPM, NDE1, CFDP1, LRWD1, KNSTRN, MAD1L1

GO:0000778

CC

condensed nuclear chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed nuclear chromosome and provides an attachment point for the spindle microtubules.

BUB1B, CENPA, MIS18BP1

GO:0000779

CC

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

CEBPB, NCAPD3, CENPE, CBX3, NCAPD2, SGOL1, AURKB

GO:0000780

CC

condensed nuclear chromosome, centromeric region

The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

AURKA, CENPA, CENPC, KMT5B, SGOL1, KMT5C, AURKB

GO:0000781

CC

chromosome, telomeric region

The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.

CHEK1, RAD51D, RNF8, TNKS, H2AFX, CDK2, MRE11A, BLM, PTGES3, RIF1, SETX, SIRT2, SMC5, EID3, ERCC4, SMC6, TEP1, DHX36, POT1, NSMCE4A

GO:0000783

CC

nuclear telomere cap complex

A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome.

XRCC5, TERF1, ACD, POT1

GO:0000784

CC

nuclear chromosome, telomeric region

The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.

SMCHD1, ORC5, KDM1A, NBN, H2AFY, RAD51D, TOX4, TNKS, SSB, CDK1, ERCC1, PARP1, PCNA, XRCC5, SP100, MCM3, POLD1, POLR2B, HIST1H2BB, MCM4, MCM5, MCM7, PPP1CC, FEN1, MSH2, CBX5, ATRX, MCM2, MRE11A, DNA2, BRCA2, TERF1, PPP1CA, PPP1CB, HIST1H4A, HIST1H3D, PRKDC, CBX1, H3F3A, PURA, RAD51, CBX3, ORC1, MCM6, LRIF1, THOC7, ALYREF, THOC2, RAD50, ERCC4, NABP1, ACD, THOC3, PPP1R10, DCLRE1C, NABP2, TNKS2, PIF1, OBFC1, POT1, GAR1, H2AFY2, ORC3, SUN2

GO:0000785

CC

chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.

HMGN4, CHEK1, OIP5, RAD21, MAF, TOX4, MBD4, MYCN, HMGN2, RB1, POLA1, CDK4, JUNB, JUND, SFPQ, CCND2, MCM7, TMPO, TMPO, CENPF, UBE2A, MCM2, PLK1, UBE2B, CBX1, RAD51, CBX3, HDAC1, KIF22, JMJD1C, PDS5A, ESCO2, NIPBL, WAPL, SLF2, FBXO18, AHCTF1, PPP1R10, DSCC1, PINK1, NUCKS1, SUV39H2, PDS5B, PARPBP, MIS18A, PLK2, SMC3, L3MBTL1

GO:0000786

CC

nucleosome

A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.

H2AFY, H2AFZ, HIST1H2AG, HIST1H1E, H2AFX, HIST1H1C, HIST1H2AD, HIST1H2BB, CENPA, HIST1H4A, HIST1H2BC, HIST1H3D, H3F3A, HIST1H1A, SHPRH, HIST2H2BE, HIST2H2AA3, H2AFV, KAT6B, H1FX, KAT6A, HIST1H2AC, HIST1H2BH, SLF1, H2AFJ, H2AFY2

GO:0000788

CC

nuclear nucleosome

A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures.

HIST1H2BK, HIST1H2BB, CENPA, HIST1H2BD, HIST1H2BC, HIST1H3D, H3F3A, HIST2H2BE, HIST3H2A, HIST1H2BH, MPHOSPH8

GO:0000790

CC

nuclear chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

EME2, DFFA, ARID1A, ENC1, POLR3G, KLF4, SNAI2, KDM1A, H2AFY, NCOR1, NFATC1, CBX7, MBD3, ACTL6A, ESR1, TP53, HNRNPC, HIST1H2AG, AR, IRF1, TCF4, TCF3, MUC1, H2AFX, JUNB, JUND, TAL1, CEBPB, RCC1, NR1D1, HIST1H2AD, HMGB2, STAT3, BUD31, NRIP1, NASP, UBE2A, SMARCA2, SMARCA4, MSH6, HIRA, DLX5, ACTB, UBE2B, SMAD3, E2F1, MEF2A, HIST1H1A, PPARD, RELA, MXD1, GABPA, RAD51, RBBP4, CHAF1A, CHAF1B, NR1H3, SMAD4, HDAC1, RUNX3, RUNX2, CHD4, NCOA1, SMAD2, EZH2, HIST2H2AA3, SMARCD3, H2AFV, CCAR2, SMARCC2, IPO4, HDAC2, CREBBP, RAD50, SMARCC1, HIST1H2AC, WBP2, EME1, RAD51AP1, CDCA5, PAWR, EHMT2, UHRF1, TCF12, CITED2, POLR3GL, H2AFJ, TIPIN, NUCKS1, PLCB1, TCF7L2, ASF1B, H2AFY2, TRPS1, TIMELESS, ASF1A, NCOR2, NCOA3

GO:0000791

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euchromatin

A dispersed and relatively uncompacted form of chromatin.

HSF1, RRP1B, UHRF1

GO:0000792

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heterochromatin

A compact and highly condensed form of chromatin.

CBX7, MBD3, UBA1, HSF1, RRP1B, UHRF1, SMARCAD1

GO:0000793

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condensed chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

SMARCA5, H2AFY, BANF1, SMC2, HMGB1, TOP2A, CDK2, HMGB2, MKI67, RAD51, NCAPD2, CHAMP1, FANCD2, BAZ1B, L3MBTL1

GO:0000794

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condensed nuclear chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.

CHEK1, RGS12, RAD51C, BRD4, H2AFX, RCC1, TUBG1, LRPPRC, NEK2, RAD51, SMC1A, RRS1, RSPH1, TTN, TOPBP1, P3H4, KIFAP3, RAD50, NIFK, ADD3, SUN2

GO:0000795

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synaptonemal complex

A proteinaceous scaffold found between homologous chromosomes during meiosis.

SYN1, MLH1, PLK1, PMS1, UBE2I, WAPL, P3H4, MLH3

GO:0000796

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condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

SMC2, NCAPH, NCAPD2, NCAPG, SMC4

GO:0000797

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condensin core heterodimer

The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation.

NCAPD2

GO:0000798

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nuclear cohesin complex

A cohesin complex required for cohesion between sister chromatids that remain in the nucleus.

WAPL

GO:0000799

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nuclear condensin complex

A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus.

NCAPD3, NCAPD2

GO:0000800

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lateral element

A proteinaceous core found between sister chromatids during meiotic prophase.

BRCA1, BRCA2, BLM, RAD51, SMC3

GO:0000803

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sex chromosome

A chromosome involved in sex determination.

SMC5, SMC6

GO:0000805

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X chromosome

The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.

SIN3B, CDK2

GO:0000806

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Y chromosome

The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males.

SIN3B, CDK2

GO:0000808

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origin recognition complex

A multisubunit complex that is located at the replication origins of a chromosome.

ORC5, ORC1, ORC3, ORC6

GO:0000811

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GINS complex

A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.

GINS1, GINS4, GINS2

GO:0000812

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Swr1 complex

A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.

ZNHIT1, ANP32E, ING3, RUVBL2, RUVBL1, TRRAP

GO:0000813

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ESCRT I complex

An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.

VPS37C, UBAP1L, VPS37A, MVB12A

GO:0000815

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ESCRT III complex

An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes.

CHMP2A, CHMP4B

GO:0000818

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nuclear MIS12/MIND complex

A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.

DSN1

GO:0000836

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Hrd1p ubiquitin ligase complex

A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78).

OS9, SYVN1, SEL1L

GO:0000838

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Hrd1p ubiquitin ligase ERAD-M complex

A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.

AMFR

GO:0000839

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Hrd1p ubiquitin ligase ERAD-L complex

A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.

SYVN1, SEL1L

GO:0000922

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spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

DYNC1I1, WDR62, PRC1, CEP104, VPS4B, TNKS, LATS1, CCNB1, CDC25B, CTNNB1, NUP62, RANGAP1, BRCC3, CENPF, KNTC1, NEK2, KIF11, PLK1, CALM2, RAB11A, PPP2CB, GOLGA2, CDC20, LRMP, MAD2L1, UNC119, CKAP5, DCTN1, NEDD9, MAPK14, CSPP1, FAM110C, ODF2, SGOL1, FRY, PSRC1, CEP128, CKAP2L, NIN, POC1A, POC1B, NEK7, FBF1, NUDCD2, CKAP2, TOPBP1, HAUS1, RMDN1, SPDL1, CEP19, RMDN2, SPAG5, CEP89, PKP4, CDC6, KATNB1, CEP44, DSN1, AUNIP, NEK6, LATS2, RASSF1, TPX2, CDC14A, SMC3, SBDS, KNSTRN, MAD1L1

GO:0000923

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equatorial microtubule organizing center

A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis.

MZT1, TUBGCP3

GO:0000930

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gamma-tubulin complex

A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species.

TUBG1, CKAP5, UXT

GO:0000932

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cytoplasmic mRNA processing body

A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci.

MEX3A, ZC3H12D, CNOT1, POLR2D, CNOT3, EIF4E, TOP1, PSMC3, PSMA2, PSMA4, ZFP36, PSMC2, LSM3, LSM6, POLR2G, ZFP36L1, SQSTM1, CAPRIN1, PUM1, PAN3, SAMD4B, DCP2, LSM14A, TNRC6A, RBPMS, EDC3, AJUBA, LIN28A, RC3H2, APOBEC3G, AGO4, PNRC2, EIF4ENIF1, LIMD1, CNOT7, NOCT, AGO2, TNRC6B, SAMD4A, CARHSP1, LSM2, LSM4, YTHDF2

GO:0000938

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GARP complex

A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles.

VPS52

GO:0000939

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condensed chromosome inner kinetochore

The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.

CENPA

GO:0000940

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condensed chromosome outer kinetochore

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

BUB1B, CENPF, CENPE, SKA3, SKA2, SKA1, SPDL1

GO:0000941

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condensed nuclear chromosome inner kinetochore

The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.

DSN1

GO:0000942

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condensed nuclear chromosome outer kinetochore

The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

NDC80, BUB1, CCNB1, PLK1

GO:0000974

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Prp19 complex

A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.

PLRG1, POLR2A, CDC5L, CRNKL1, RBM22, PRPF19

GO:0001401

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mitochondrial sorting and assembly machinery complex

A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.

SAMM50

GO:0001405

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presequence translocase-associated import motor

Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix.

GRPEL1, PAM16

GO:0001518

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voltage-gated sodium channel complex

A sodium channel in a cell membrane whose opening is governed by the membrane potential.

SCN9A

GO:0001520

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outer dense fiber

A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins.

AK1, ODF2, RSPH1

GO:0001527

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microfibril

Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.

FBN1, FBN2, MFAP2, MFAP5, LTBP1, THSD4, ADAMTS10

GO:0001533

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cornified envelope

A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes).

CSTA, ANXA1, DSP, SPRR2B, KAZN, SPRR2G, SPRR3

GO:0001534

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radial spoke

Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.

RSPH4A, C6orf165

GO:0001650

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fibrillar center

A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.

UTP15, UTP4

GO:0001651

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dense fibrillar component

A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.

SNU13

GO:0001652

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granular component

A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.

CLEC3B, CDKN2AIP

GO:0001669

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acrosomal vesicle

A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.

SPAG9, CRCP, SPINK1, KIT, SKIL, DRD2, TCP1, NCF2, ZP3, CALR, CTNNA1, NUDT1, NOTCH1, CXADR, LOXL1, MORN2, SV2B, ARC, IQUB, CASC5, ENKUR, SLIRP, RACGAP1, VEZT, TSKS, POMT1