GO:0007028

BP

cytoplasm organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

RRN3

GO:0007029

BP

endoplasmic reticulum organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.

VAPB, CAV2, SEC61A1, ATL3, ATL2, CCDC47, VMP1, SEC16B, LMAN2L

GO:0007030

BP

Golgi organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.

RAB29, SURF4, ATP8B1, OBSL1, HTT, CSNK1A1, CSNK1D, TMED10, CDC42, RAB2A, RAB1A, ARHGEF7, COG2, CUL7, PRKD1, TMED2, TRIP11, TJAP1, ARHGAP21, ATL3, HACE1, ATL2, ATP8B4, GBF1, USP6NL, OPTN, VMP1, LMAN2L, BLZF1, BAG5, NSFL1C

GO:0007031

BP

peroxisome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.

PEX12, PEX14, PEX11B, SCP2, ABCD3, PEX3, TMEM135, LONP2, SEC16B

GO:0007032

BP

endosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.

STX6, RAB5B, LAMTOR1, HOOK3, PIK3C3, SNX33, HOOK2, ALS2, AKTIP, RAB22A, ARFGEF2

GO:0007033

BP

vacuole organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.

VPS4B, NDP

GO:0007034

BP

vacuolar transport

The directed movement of substances into, out of or within a vacuole.

CLN3, NDFIP1

GO:0007035

BP

vacuolar acidification

Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.

ATP6V0E1, SLC11A1, TCIRG1, ATP6V0A1, ATP6V1H

GO:0007037

BP

vacuolar phosphate transport

The directed movement of phosphates into, out of or within a vacuole.

FGFR1

GO:0007039

BP

protein catabolic process in the vacuole

The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases.

TCIRG1

GO:0007040

BP

lysosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.

TPP1, ABCA1, GAA, ARSB, TFEB, NAGLU, CLN3, GNPTAB, LAMTOR1, HOOK3, MFSD8, TPCN2, HPS1, HOOK2, LYST, AKTIP, HPS4, TMEM106B, NAGPA

GO:0007041

BP

lysosomal transport

The directed movement of substances into, out of or within a lysosome.

NPC1, ARSB, HGSNAT, VPS52, PCSK9, TMEM106B

GO:0007042

BP

lysosomal lumen acidification

Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.

CLN5, SNAPIN, PPT1, CLN3, CLN6

GO:0007043

BP

cell-cell junction assembly

The aggregation, arrangement and bonding together of a set of components to form a junction between cells.

CDH5, GJC1, TJP1, FSCN1, FLCN, HDAC7, NR1H4, PKP4, PARD6B, TRPV4, HEG1, TLN1

GO:0007044

BP

cell-substrate junction assembly

The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.

FN1, ITGB3, ITGA5, ITGA6, TNS1, TLN1

GO:0007049

BP

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

SUPT5H, CDK2AP1, MAPK13, KLK10, SIAH2, CREBL2, CCNT1, CCNT2, PRPF40A, TACC1, GMNN, USP2, TUSC2, GNAI2, KRT18, GNAI3, DTYMK, MAPK3, MAPK1, RBL1, CCND2, CCND3, AHR, RGS2, MAP3K8, NASP, MCM2, ERF, ANXA11, SIK1, CKS1B, PPP1CA, BLCAP, GNAI1, RACK1, ERH, CDK5, INSM1, PRKCD, RBBP4, CDC20, CHAF1A, CHAF1B, MAPK7, GPS2, IKZF1, CUL4B, TP53BP2, CAMK1, E2F2, WTAP, ZMYND11, RPS6KA1, DIXDC1, PKN2, LIN52, ESCO2, AVPI1, CROCC, RIF1, KCTD11, MAEA, SIAH1, CCAR1, MRPL41, HACE1, CCAR2, BANP, HJURP, RCBTB1, APPL2, DBF4B, CTCFL, URGCP, RB1CC1, PARD3, CHTF18, PTP4A1, LIN37, SENP5, ZFYVE19, UHRF2, UHRF1, GPER1, PDCD2L, PELO, MARVELD1, BEX2, PARD6B, RBM38, TSPYL2, RASSF4, TXNIP, SUV39H2, PARD6A, BRD7, CYLD, TXLNG, ARL8B, THAP1, HMG20B, BCCIP, TLK1, CCPG1, USP22, RABGAP1, EID1

GO:0007050

BP

cell cycle arrest

A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).

APBB1, IRF6, PPM1G, HBP1, BRINP1, GAS7, NBN, ERN1, CDC123, PPP1R15A, AK1, MYC, TGFB1, PRNP, TP53, INHA, RB1, THBS1, INHBA, CXCL8, IRF1, SKIL, GADD45A, APC, CALR, IL12A, DDIT3, TGFBR1, CDKN1A, CDKN2B, CDKN2C, MSH2, CDKN1B, TSC2, CDKN1C, CDK7, MAP2K6, PRKAG1, PRKAA2, GAS1, TGFB2, SMAD3, PKD1, FOXO4, CDK6, MAP2K1, NOTCH2, KHDRBS1, ILK, PKD2, CUL2, CUL3, CUL4A, GAS6, RHEB, DHCR24, STK11, ZFHX3, CDKN3, TBRG1, LAMTOR1, DDIAS, KMT2E, JMY, UHMK1, KAT2B, APBB2, CUL5, TBRG4, TP53INP1, KIF20B, BARD1, MLST8, STRADB, RRAGC, TCF7L2, RRAGD, RASSF1, RPRM, ZAK, EIF2AK4, PRKAG3, LAMTOR3, PLAGL1, PA2G4, LAMTOR2, CAB39

GO:0007051

BP

spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

AURKA, TTK, RANBP1, KIF11, CKAP5, KIZ, ASPM, AURKB, SPAG5, AUNIP, KNSTRN

GO:0007052

BP

mitotic spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

EML1, NDC80, AURKA, WDR62, TNKS, PCNT, CCNB1, STMN1, RCC1, TTK, KIF11, GPSM2, DCTN2, DYNC1H1, SMC1A, STIL, SPC25, PLK2, SUN2, SMC3, SBDS

GO:0007057

BP

spindle assembly involved in female meiosis I

The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.

AURKA, FBXO5

GO:0007059

BP

chromosome segregation

The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.

DDX3X, RIOK3, NDC80, OIP5, CIAO1, NR3C1, SLC25A5, TOP1, TOP2A, ERCC2, RCC1, PPP2R1A, BRCA1, CENPF, NEK2, NEK3, KIF11, UBE2I, CENPE, CENPC, FAM175B, PPP1R7, ESCO2, CENPW, SGOL1, CDCA2, NEK10, SKA3, HJURP, NEK9, SKA2, SKA1, ARL8A, SPAG5, SRPK1, SETDB2, NUF2, NDEL1, FAM96A, NAA60, SPC25, NEK6, ARL8B, NDE1, MIS18A, FAM96B, KNSTRN

GO:0007060

BP

male meiosis chromosome segregation

The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male.

MLH1

GO:0007062

BP

sister chromatid cohesion

The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.

NDC80, XPO1, BIRC5, RAD51C, BUB1, BUB3, RAD21, BUB1B, ZWINT, CLIP1, PPP1CC, RPS27, RANGAP1, CENPA, CENPF, RANBP2, MRE11A, KNTC1, PLK1, SEC13, NUP107, CENPE, CENPC, NUP160, CDC20, MAD2L1, ITGB3BP, CKAP5, SMC1A, KIF22, MAPRE1, PDS5A, ERCC6L, CDCA8, SGOL2, SGOL1, CENPU, CENPQ, WAPL, SMC5, CENPL, APITD1, SPC24, NUP43, NUP37, CASC5, KIF18A, SKA2, AHCTF1, SKA1, SPDL1, SEH1L, CDCA5, AURKB, CENPN, NSL1, PHB2, KIF2C, CENPK, CENPO, NUP85, HDAC8, NUF2, NDEL1, CENPH, DSN1, ZWILCH, SPC25, CENPM, PDS5B, NDE1, SMC3, MAD1L1

GO:0007063

BP

regulation of sister chromatid cohesion

Any process that modulates the frequency, rate or extent of sister chromatid cohesion.

BUB1

GO:0007064

BP

mitotic sister chromatid cohesion

The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.

RAD21, SMC1A, PDS5A, NIPBL, WAPL, GSG2, CDCA5, PDS5B, SMC3

GO:0007066

BP

female meiosis sister chromatid cohesion

The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female.

RAD51C

GO:0007067

BP

mitotic nuclear division

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

STRA13, WASL, NDC80, AURKA, PPP1R12A, CETN3, OIP5, BUB1, ENSA, BUB1B, TADA3, RNF8, HAUS5, CCNB2, TNKS, YEATS4, LATS1, PTTG1, NR3C1, CDK1, TPR, HGF, RCC1, CCNA2, CDK11B, CDK2, WEE1, CDC25A, CDC25B, CDC25C, CLIP1, NUP62, CCNF, BRCC3, CSNK1A1, CENPF, KNTC1, NEK2, NEK3, NEK4, CCNG1, KIF11, HMGA2, PLK1, TERF1, GEM, ARPP19, RPS6, DYNLT1, UBE2I, CCNA1, CDK3, SRSF2, CENPC, NSUN2, CDC20, ITGB3BP, TUBB3, DCTN2, CKAP5, DCTN1, NEDD9, KIF22, SEPT2, MAPRE2, MAPRE1, SEPT7, CCNG2, ERCC6L, CENPW, SGOL1, CDCA2, REEP3, MIS18BP1, BORA, HAUS6, CENPV, PBRM1, NCAPG2, ANKLE2, SKA3, SIRT2, SMC5, ASPM, APITD1, SPC24, PAPD5, NUP43, NUP37, CASC5, MPLKIP, NEK9, SNX33, SKA2, ARHGEF2, FBXW5, SKA1, ARL8A, HAUS1, ANAPC16, CDCA5, MASTL, CENPN, BOD1, NSL1, VCPIP1, PBK, MARK4, NEK1, KIF20B, SNX18, SETDB2, NUP88, CDCA3, PKMYT1, KIF2C, CDC6, HAUS7, VRK1, FAM64A, TIPIN, NUF2, LRRCC1, USP44, ANAPC1, TRIOBP, TTYH1, FAM83D, HAUS4, ZWILCH, SPC25, EML4, NEK6, KMT5A, ANLN, LATS2, HELLS, KIF15, HAUS2, MIS18A, KLHL9, KLHL42, KLHL13, FBXL7, CDC23, ANAPC5, ANAPC4, FBXO5, TPX2, FZR1, ANAPC10, TIMELESS, MAPRE3, CDK11A, SMC3, RUVBL1, SUGT1, SNX9

GO:0007070

BP

negative regulation of transcription from RNA polymerase II promoter during mitosis

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis.

RB1, SMARCA4

GO:0007076

BP

mitotic chromosome condensation

The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.

SMC2, NCAPD3, NCAPH, NCAPD2, TTN, CDCA5, NCAPG, NUSAP1, SMC4

GO:0007077

BP

mitotic nuclear envelope disassembly

The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell division occurs.

NUPL2, BANF1, NUP155, CCNB2, CTDNEP1, LMNA, PRKCB, CDK1, TPR, CCNB1, PRKCA, NUP62, NUP153, RANBP2, EMD, PLK1, NUP107, RAE1, NUP160, LPIN1, NUP93, CNEP1R1, NUP43, NUP37, NUP35, NEK9, NUP210, NUP205, SEH1L, NUP88, VRK1, NDC1, NUP58, NUP85, NEK6, NUP50

GO:0007079

BP

mitotic chromosome movement towards spindle pole

The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis.

CENPE, KPNB1, DLGAP5, KATNB1

GO:0007080

BP

mitotic metaphase plate congression

The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.

CHMP2A, VPS4B, CCNB1, RAB11A, CENPE, CUL3, KIF22, KPNB1, RRS1, KIF14, CDCA8, PSRC1, KIF18A, PIBF1, SPDL1, SEH1L, CDCA5, KIF2C, KIFC1, CHMP4B, CDC23

GO:0007084

BP

mitotic nuclear envelope reassembly

The cell cycle process that results in reformation of the nuclear envelope during mitotic cell division.

BANF1, LMNA, PPP2R1A, EMD, REEP3, ANKLE2, VRK1

GO:0007088

BP

regulation of mitotic nuclear division

Any process that modulates the frequency, rate or extent of mitosis.

DAPK3, OBSL1, RCC1, CDC25C, MKI67, CAV2, NEK2, CDC42, CDK13, CUL7, MAP9, BORA, KIF20B, PKMYT1, CCDC8, FBXO5, L3MBTL1

GO:0007089

BP

traversing start control point of mitotic cell cycle

A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity.

MDM2, CDK10, CDC6

GO:0007091

BP

metaphase/anaphase transition of mitotic cell cycle

The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.

BUB1B, CDC27, CDC23, TACC3

GO:0007093

BP

mitotic cell cycle checkpoint

A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

BUB1, BUB1B, NBN, ZWINT, TGFB1, RB1, CDKN2B, KNTC1, RPS6, RPL24, DLG1, MAD2L1, SMC1A, INTS3, NABP1, NABP2, ZWILCH, PLK2, MAD1L1

GO:0007094

BP

mitotic spindle assembly checkpoint

A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.

ZNF207, BUB1, BUB3, BUB1B, TPR, APC, TTK, CENPF, PLK1, MAD2L1, TEX14, MAD1L1

GO:0007095

BP

mitotic G2 DNA damage checkpoint

A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.

FOXN3, NBN, CDK1, CCNA2, MRE11A, HMGA2, BLM, FOXO4, TOPBP1, SLF1, TAOK3, FANCI

GO:0007096

BP

regulation of exit from mitosis

Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity.

KNTC1, SIRT2, ANLN, CDC23, CDC14A

GO:0007097

BP

nuclear migration

The directed movement of the nucleus.

CDC42, SYNE2, SUN2

GO:0007098

BP

centrosome cycle

The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.

CETN3, CDK1, NPM1, GADD45A, BRCA1, TUBE1

GO:0007099

BP

centriole replication

The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type.

PLK4, WDR62, CEP152, CDK2, CEP135, CNTROB, CENPJ

GO:0007100

BP

mitotic centrosome separation

Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.

AURKA, KIF11, NDEL1, NDE1

GO:0007113

BP

endomitotic cell cycle

A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.

CIB1

GO:0007126

BP

meiotic nuclear division

One of the two nuclear divisions that occur as part of the meiotic cell cycle.

CDK2, MKI67, RAD51, SMC1A, RAD54L, TUBGCP3, DUSP13, SMC3

GO:0007127

BP

meiosis I

The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei.

CKS2

GO:0007129

BP

synapsis

The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete.

MLH1, MRE11A, NDC1, FANCD2

GO:0007130

BP

synaptonemal complex assembly

The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination.

MEIOC, TRIP13, P3H4, TEX15, AGO4, MLH3

GO:0007131

BP

reciprocal meiotic recombination

The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.

RAD51C, RAD21, RAD51D, FSBP, MSH3, MSH2, MRE11A, MSH6, RAD51, TRIP13, TOP6BL, RAD50, MND1, MLH3, RAD54B

GO:0007140

BP

male meiosis

A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.

TEX14, TDRD9, KIF18A, TEX15, AGO4, CYP26B1, MLH3

GO:0007141

BP

male meiosis I

A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline.

MEIOC, RAD51C, BRCA2, CCNA1, TRIP13

GO:0007143

BP

female meiotic division

A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.

EREG, PRKAR1A, PPP2R1A, HSF1, KIAA0430

GO:0007144

BP

female meiosis I

The cell cycle process in which the first meiotic division occurs in the female germline.

MEIOC, CDC25B, TRIP13, MLH3

GO:0007147

BP

female meiosis II

The cell cycle process in which the second meiotic division occurs in the female germline.

MASTL

GO:0007154

BP

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

OIP5, ANG, NRG1, TRIP10, FRAS1, KREMEN1, ENPP5

GO:0007155

BP

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

SSPO, CHL1, CYR61, ISLR, NCAN, TOR1A, CASK, PDZD2, ADAM12, TGFB1I1, MTSS1, EDIL3, NUAK1, NRP2, PLXNC1, SORBS3, LPXN, CTNND1, ADAM23, WISP2, SORBS2, FARP2, CLSTN1, WISP1, BMP10, FN1, AMBP, BGLAP, VTN, VWF, ATP1B1, APP, ITGB3, ITGB2, ICAM1, ITGAV, LAMB1, THBS1, ITGA5, RPSA, SPP1, PTPRF, HAPLN1, LAMC1, ITGAM, COL6A1, COL6A2, COL6A3, GP1BB, CCL4, CCL2, NCAM1, VCAN, SELL, CD99, B4GALT1, ITGB4, PECAM1, ATP2A2, CD36, PRKCA, ITGA2, CDH2, CD58, VCAM1, CD33, ITGAX, COL5A1, MAG, S1PR1, KITLG, CD9, TNXB, NME2, ANOS1, IL32, LAMA2, TNC, APC, FPR2, AZGP1, ITGB8, CTGF, EPHA3, CTNNA1, CTNNB1, ACTN2, SPAM1, ITGAE, COL15A1, COL18A1, ABL2, MCAM, CXCL12, CD151, CD97, COMP, BCAM, PRKX, EFNB2, EPHB4, EPHA4, EMP2, CDH6, CDH11, CDH15, RHOB, RAC1, SIRPA, OLR1, ADAM17, TNFAIP6, MYBPC1, COL4A3, APBA1, DSC2, DST, CD164, TYRO3, COL16A1, DDR1, MFGE8, CD47, TROAP, CNTN1, CDH17, ARHGAP5, MMRN1, PTK7, ITGB3BP, ADAM9, LSAMP, SEMA5A, ALCAM, ITGA9, COL4A6, NID2, DSG2, DGCR6, SCARF1, SELPLG, ADGRE1, GAS6, HES1, NEDD9, FAT1, SSPN, GPNMB, POSTN, NECTIN1, PTPRK, TGFBI, ZYX, IGFBP7, LAMA4, CYP1B1, LAMA3, AOC3, IGSF11, THEMIS2, RGMB, OLFM4, MAEA, AGGF1, CHST4, STAB2, CNTNAP5, TNR, SYMPK, LPP, BCAN, MAGI1, SIGLEC11, CSF3R, FEZ1, COL12A1, CIB1, OMD, FERMT1, SPON2, EMILIN2, PRKD2, TINAGL1, PCDHAC1, PNN, SPON1, TMEM8A, CASS4, STAB1, AATF, FLRT1, CNTN3, CTNNAL1, CFDP1, ITGA11, PCDHA7, PCDHA6, PCDHA4, GNE, SIGLEC7, SSX2IP, LOXL2, PCDHB3, PCDHA8, PCDHA5, PCDHA3, PCDHA2, PCDHA11, PCDHA10, PCDHA1, PCDHAC2, ADGRG1, LAMC3

GO:0007156

BP

homophilic cell adhesion via plasma membrane adhesion molecules

The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.

PCDH17, PLXNB2, MPZL2, CLSTN1, ITGB1, PVR, CDH2, PTPRM, CDH5, CD200, PIK3CB, CDH6, CDH11, CDH12, CDH13, CDH15, PKD1, DSC2, PCDH1, SMAGP, CDH17, DSG2, FAT1, NECTIN1, SDK2, SDK1, PCDH19, FAT3, CADM1, CDHR2, PCDH11Y, PCDHAC1, CLSTN2, PCDH9, ROBO2, PCDH18, NECTIN3, CELSR3, TENM3, PCDH10, CDH22, PCDHGC3, PCDHA7, PCDHA6, PCDHA4, PCDHA12, IGSF9B, PCDHB9, PCDHB3, PCDHB14, PCDHA9, PCDHA8, PCDHA5, PCDHA3, PCDHA2, PCDHA13, PCDHA11, PCDHA10, PCDHA1, PCDHAC2

GO:0007157

BP

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.

ICAM1, ITGA5, PVR, SELE, CDH2, VCAM1, CBLN1, PTPRD, CD6, CD200, LGALS7, CXADR, CD164, SMAGP, ALCAM, NECTIN1, TENM4, NLGN1, CADM1, CD209, NECTIN3, TENM3

GO:0007158

BP

neuron cell-cell adhesion

The attachment of a neuron to another cell via adhesion molecules.

NCAM2, CNTN4, NLGN4X, NLGN1, TNR, NRXN1

GO:0007159

BP

leukocyte cell-cell adhesion

The attachment of a leukocyte to another cell via adhesion molecules.

ITGB2, ICAM1, ITGB1, ITGA5, CCL5, EZR, SELE, VCAM1, NT5E, CD40LG, SYK, CD209

GO:0007160

BP

cell-matrix adhesion

The binding of a cell to the extracellular matrix via adhesion molecules.

ITGB1BP1, BCL2L11, TECTA, ITGA10, ECM2, COL3A1, FGA, FGB, FGG, VTN, ITGB3, ITGB2, ITGB1, ITGAV, NID1, CD44, ITGB4, ITGA2, ITGB5, VCAM1, ITGA6, COL5A3, ITGA3, CTGF, CTNNB1, BCAM, EMP2, ADAMTS12, RAC1, PKD1, CDK5, TIAM1, ILK, ADAM9, NID2, ZYX, COL13A1, MUC4, SORBS1, JAM3, SIGLEC1, ITGA11, MKLN1, EPDR1, COL17A1, HPSE, TIMM10B, LYVE1

GO:0007161

BP

calcium-independent cell-matrix adhesion

The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction.

FN1, ITGB1, PKD1

GO:0007162

BP

negative regulation of cell adhesion

Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.

ADAM10, PLXNB2, LPXN, DAB1, KNG1, RASA1, ERBB3, FBLN1, TNC, ARHGDIA, ARHGDIB, CDH13, JAM2, CD164, PDE3B, SEMA5A, ANGPT1, TGFBI, CBLL1

GO:0007163

BP

establishment or maintenance of cell polarity

Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.

SPINT2, CCL4, CTNNA1, CDC42, ACTR3, ACTR2, CRB1, DLG1, MAP7, FAT1, SFRP5, NPHP3, PARD3, SYNE2, PARD6B, PARVA, CDC42BPB

GO:0007165

BP

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

ARHGAP42, GPR89A, AIP, APBB1, CLIC1, TNFRSF11B, PIK3CD, CHL1, CLDN4, IRS4, PTGES, MAP2K7, NRP1, TNFRSF10C, MGST3, RGS12, PPP1R12A, FYB, NPC1, ANGPT2, NPHP1, OGT, INPP4B, TLR3, CAPN5, CLDN3, RIPK2, AKAP10, TYROBP, PPP1R12B, SH3BP5, ADCY3, LY75, ADCY9, CREBL2, GREM1, TLR2, PDE8A, JAK2, LPXN, TRIM13, ZPR1, ZNF217, FLNB, ULK1, SKAP2, BCAR3, TNFSF13, RASSF9, PDE5A, WISP2, PDE9A, FGF18, PLEKHG5, NFAT5, FAM13A, IKBKAP, PDE8B, WISP1, CXCL14, CLIC3, GUCA1C, PEX11B, ACTL6A, EGFR, PLAU, C3, GNRH1, POMC, PENK, CGA, FSHB, LHB, GCG, IL1B, CD4, FGA, FGB, FGG, ESR1, OPN1SW, RAF1, ANXA1, NR3C1, CD74, ERBB2, GNAI2, IGF1, INHA, PRKCB, CCK, PGR, S100A9, S100A6, NPM1, CSF1R, HSP90AA1, LYN, IGF1R, MET, ANXA5, IGFBP1, NMB, FGF2, CXCL1, LGALS1, SPARC, ANXA4, PDGFRB, GPR89B, CXCL8, AR, NR2F1, TXN, KIT, IAPP, CHRNB1, RALA, RALB, BCR, VDR, IGF2R, CDK4, FCGR1A, CCL4, CCL2, HLA-DOB, JUP, RAC2, IFNGR1, HIVEP1, CREB1, PECAM1, IL7R, STMN1, GJA1, IGFBP2, ATF6, EPOR, CD53, FST, CD33, CHRM3, TRH, CAPN3, RASA1, FPR1, KITLG, C5AR1, MDK, FGF7, ERBB3, IGFBP4, NR4A1, EVI2A, MRC1, TNFSF4, ITPKA, IL4R, NR2F2, IGFBP6, IGFBP5, CXCR2, EDNRA, FAS, MAPK1, GRN, PTPRM, TNFRSF8, IMPA1, LTK, CASP1, EEF1D, GNA11, PDIA3, CCND3, CHRNA5, TSPO, ADORA1, SRI, NTS, GDI1, FGF9, SDC4, HIVEP2, GABRA5, AKT1, AKT2, SFN, S100A11, FCGR2B, STX2, LSP1, PHB, ADM, ADRA1A, IRS1, TIE1, ADRBK2, DEK, CHKA, CHRNA7, ACVR1B, TGFBR1, GNL1, LTBR, PPARG, COL15A1, STAT3, ELK3, ARHGAP25, PIK3CB, ABL2, IL12RB1, CXCL5, NR4A2, RANBP1, NAMPT, RANGAP1, IQGAP1, OR3A3, CXCL12, SOX9, NMU, CSNK1A1, CSNK1D, INPP1, CSNK1E, PGF, VEGFC, HINT1, GDI2, TNFSF10, BCAM, IRAK1, CLCN6, HDGF, MAP2K6, RCAN1, YARS, PRKAG1, PRKAA2, GEM, TPTE, SOX8, RAP2B, FGF12, GNG11, RAP1A, GNB1, YWHAZ, GNG5, IGBP1, GTF2I, DLG4, CCL20, HLA-DRB3, CCL8, CXCL6, TNFAIP6, VLDLR, ATP2C1, MPP1, NDP, IL9R, CD83, IL5RA, IL1RL1, OCRL, MAP2K1, TEK, CREM, PLAUR, KRT17, TLE1, TLE3, CD164, PRKCD, TYRO3, KHDRBS1, SOS1, IL10RB, PDE4C, PLCXD2, EPS8, ANK3, STK4, TRAF1, MAP2K5, MAPK7, PAK2, CBLB, PTK7, MTA1, ITGB3BP, PPP2R5C, PDE3B, PDCL, PDAP1, IL18R1, NAE1, ITPK1, IQGAP2, TP53BP2, ACVR2B, ALCAM, RAPGEF1, PDE7A, CAMK1, ARHGEF7, SCARF1, GAS6, GRB14, NEDD9, SPARCL1, ITPR2, ITPR1, RASA3, PPP2R5D, ARHGAP19, EBP, PRKD1, PPP2R5A, PTGES3, NECTIN1, PTPRK, RASA2, ERBB4, RALBP1, RPS6KA2, RHEB, TLR1, RPS6KA1, SHB, MAPRE2, TRADD, TRIP10, SMAD1, ZYX, EXT1, PKN1, PKN2, MAPK14, DPYSL2, CARTPT, HIF1A, AMHR2, TXNRD1, HIVEP3, SFRP5, ARHGAP21, GKAP1, PLCXD3, SIGIRR, OR52E8, TENM4, RGMB, ARHGAP11A, SARM1, DTHD1, RASSF6, SYDE1, RAPH1, RASGRP2, CXXC5, PLPPR4, ZFYVE16, MAVS, ARHGAP22, NET1, SRGAP1, TMED4, RASSF3, PDPN, ZDHHC17, NOSTRIN, SLC44A2, RTKN2, UNC5B, TAGAP, ARHGAP24, PLPP5, APPL2, GPRC5A, LILRB1, RASSF8, RIN3, C18orf32, RHPN1, DLG5, MICAL1, SLC20A1, SECTM1, ARAP3, ARAP2, STARD8, SPOCK2, NSMAF, SORL1, ESR2, TFG, STAM, CREBBP, INPP5D, TANK, KIFAP3, CDS1, FGF13, FGF11, FGF14, RIT1, TNFRSF25, EXT2, MR1, ARRDC3, OPTN, PLPPR2, CDKN2AIPNL, ARAP1, INPP4A, DLC1, NR1H4, CSF3R, HBEGF, STAC, P2RX4, DOK1, SMAD5, LITAF, EPAS1, SH3GL2, GDF15, SPOCK3, NDFIP1, SALL3, CD244, TOLLIP, WWP1, BCL11A, RASSF4, SMOC2, SP110, NEK6, PDE7B, PLCB1, KIF13B, DLL4, CDC42SE1, SNX15, KCNIP2, GPR27, NDFIP2, PAG1, SPHK1, FAM13B, VAPA, ARHGAP23, TENM3, PAK7, ARHGAP20, PI4KB, RNF14, LIMD1, ASIC3, LNPEP, CNOT7, PITPNC1, CDC42EP3, PILRA, AMFR, INTS6, MKLN1, CORO1C, APLN, PYCARD, HPCAL4, SUFU, NDRG2, ARHGAP26, SMC3, AKT3, PLAA, RASD1, TNFSF13B, BTRC, PKIG, GOLT1B, STARD13, HBS1L, IRS2, DTNA, CDC42BPB, WIF1, LYVE1, STK24, CSNK1G3, TNFRSF11A

GO:0007166

BP

cell surface receptor signaling pathway

A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

TSPAN4, TSPAN6, TSPAN2, ADAP1, ADGRL2, TDP2, TSPAN13, TSPAN12, EGFR, F2, AGT, PRL, CD4, ANXA1, ERBB2, INHA, EDN1, ADRB2, INHBA, CD14, PTPRC, MET, CD28, IFITM1, GP1BB, CCL2, MIF, IL1R1, PRLR, CD36, NPPB, IL7R, LAG3, TSPAN8, CD53, EDN2, CD9, CXCR2, NPY1R, KLRC1, CD27, OXTR, SSTR1, CCKBR, BSG, NUP62, IFNGR2, ADCYAP1R1, TSPAN7, LIFR, MTNR1A, LEPR, CD151, IFNAR2, CSNK1A1, CD97, NPY2R, PTH2R, MTNR1B, AGTR2, TNFSF10, GEM, TIRAP, CD81, PIP4K2B, IRF9, COL4A3, KHDRBS1, TNK2, MERTK, TSPAN31, FADD, BIRC3, ADGRE1, CASP8, NPY5R, MAPK14, LY6E, CTF1, GPR157, JMJD6, ADGRD1, GPR126, ADGRA3, TRPV1, GPR98, TNFRSF25, MAGI1, TSPAN18, DOK1, PRMT1, SEMA6A, ADGRL3, MKNK2, CLCF1, EVL, ADGRG1, CABIN1

GO:0007167

BP

enzyme linked receptor protein signaling pathway

Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription.

JAK2, CD4, ERBB2, JAK3, GAS6, CNPY2

GO:0007168

BP

receptor guanylyl cyclase signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.

NPPB, NPR2, GUCY2D, GUCA1B

GO:0007169

BP

transmembrane receptor protein tyrosine kinase signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.

MUSK, CD3EAP, MTSS1, MPZL1, ANGPTL1, NGF, CD4, ERBB2, FYN, CSF1R, LYN, FGR, ERBB3, JAK1, PTPRG, LTK, FLT4, CSK, PIK3CB, ABL2, SYK, SHC2, ROR1, TEK, TNK2, RAPGEF1, ERBB4, STYK1, CSPG4, ABI1, AHI1, BLNK, DOK1, PAG1, DOK5, PILRB, PILRA

GO:0007171

BP

activation of transmembrane receptor protein tyrosine kinase activity

Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity.

GREM1, ADRB2, PRLR, EFNA5, NRG1, ANGPT1, PDGFC, PILRB

GO:0007172

BP

signal complex assembly

The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell.

PTK2, MAPK8IP2

GO:0007173

BP

epidermal growth factor receptor signaling pathway

A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

PIK3C2A, EREG, SOCS5, RPS6KA5, EGFR, NRAS, KRAS, TGFB1, AREG, ARF4, PIK3R1, BTC, CSK, PIK3CA, EPS15, IQGAP1, SOX9, GRB2, ADAM17, PTK2, PTPN11, SOS1, EFEMP1, EPS8, CBLB, GAB1, REPS2, HBEGF, GAREM1, PAG1

GO:0007174

BP

epidermal growth factor catabolic process

The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor.

RAB7A

GO:0007175

BP

negative regulation of epidermal growth factor-activated receptor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.

SOCS5, PSEN1, CBLB, GPRC5A, ERRFI1, SNX6

GO:0007176

BP

regulation of epidermal growth factor-activated receptor activity

Any process that modulates the frequency, rate or extent of EGF-activated receptor activity.

APP

GO:0007178

BP

transmembrane receptor protein serine/threonine kinase signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.

ACVR2A, ACVR1B, IRAK1, ACVR2B, BMPR2, LTBP1, MAPK14, AKAP2

GO:0007179

BP

transforming growth factor beta receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

MSTN, SMAD7, SMAD9, MAP3K7, SMAD6, GDF9, FOS, PDGFB, TGFB1, FSHB, COL3A1, JUN, COL1A2, PARP1, FURIN, UBC, SKI, SKIL, CCL2, HPGD, CREB1, ITGB5, CDH5, BMPR1A, TGFBR1, TGFBR2, ID1, GDF5, UBE2M, RHOA, TGFB2, RPS27A, UBA52, SMAD3, TGFBR3, ACVR1, PTK2, KLF10, BAMBI, ADAM9, SMAD4, PTPRK, TAB1, SMAD2, SMAD1, NEDD8, ZYX, AMHR2, GCNT2, PARD3, SMAD5, CITED1, GDF15, FUT8, HIPK2, PARD6A, DUSP22, MTMR4, NLK, USP15, F11R

GO:0007181

BP

transforming growth factor beta receptor complex assembly

The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex.

TGFBR3, FMOD, EID2

GO:0007182

BP

common-partner SMAD protein phosphorylation

The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus.

TGFB1, BMP4, TGFBR2, SPTBN1, SMAD2

GO:0007183

BP

SMAD protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins.

TGFB1, SMAD3, SMAD4, SMAD2, SMAD1, EID2

GO:0007184

BP

SMAD protein import into nucleus

The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

TGFB1, JUN, GDF5, TGFB2, SPTBN1

GO:0007185

BP

transmembrane receptor protein tyrosine phosphatase signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription.

PTPRF, PTPRD, FRS2

GO:0007186

BP

G-protein coupled receptor signaling pathway

A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).

GPR37, GNG7, FZD6, JAK2, RAMP1, FZD7, TULP3, GPR32, LGR5, GABBR2, ABCA1, ADGRL2, AGT, C3, PTH, GCG, INS, APOA1, APOE, APOC3, PPBP, PF4, OPN1SW, GNAI2, EDN1, INSR, CHRM2, CXCL1, PDGFRB, CXCL8, CCL3, IGF2R, CCL4, CCL2, CCL5, RAC2, VAV1, AREG, GNB3, ADRA2B, CXCL2, CHRM3, PDC, S1PR1, FPR1, LHCGR, FSHR, FPR2, ADRA1D, EDNRA, PTAFR, F2R, ADORA2B, AGTR1, OXTR, GNRHR, AKT1, GPR183, SSTR5, ADRA1A, HRH1, ADRA1B, PPARG, ADCYAP1R1, HTR2B, AKR1C3, PIK3CB, CXCL5, PTGFR, PTGER3, PTGER2, OR3A3, CXCL12, NPBWR1, NMU, PIK3CG, CD97, PTH2R, RGS7, AGTR2, GNG4, AKR1C2, F2RL1, CXCR4, GNG11, CALM2, GNB2, RAC1, GNAI1, GNG5, CCL20, CCL8, CXCL6, GPSM2, MC2R, GNA12, APLP2, AKAP13, PTGDR, ENPP2, ADGRE1, GPR176, ITPR3, P2RY14, NPY5R, CARTPT, SFRP5, GPR158, GPR157, ATRNL1, SFRP4, OR52E8, RGS7BP, ADGRD1, PREX2, GPR126, ADIPOR2, TPRA1, ADGRA3, SFRP1, GPRC5A, NPB, OR5A2, OR5L2, OR14C36, FRS2, GPR98, RAPGEF4, GHSR, KISS1R, ADIPOR1, GPR146, OR2A5, S1PR3, GPER1, INPP5K, TM2D1, LGR4, GPR63, OPN3, OR51E2, FZD8, ADGRL3, LGR6, ACKR4, GPRC5C, GPR27, CELSR3, GPRC5B, GHRL, GPR160, FZD4, GPR34, RASD1, ADGRG1

GO:0007187

BP

G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.

ANXA1, CHRM2, CCL2, ADRB3, CNR1, LHCGR, NPY1R, SSTR1, HTR7, SSTR5, MTNR1A, NPBWR1, MTNR1B, MC2R, HRH3

GO:0007188

BP

adenylate cyclase-modulating G-protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).

GCG, ADRB2, CHRM2, ADRB3, FPR1, CNR1, ADRA1D, AVPR2, MC4R, GRK5, ADRA1B, PTGER4, GNAI1, GNA12, WASF2

GO:0007189

BP

adenylate cyclase-activating G-protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).

ADCY3, ADCY9, PTH, GHRH, PTHLH, LHCGR, FSHR, ADORA2B, PTGER4, PTGFR, PTGER2, GNAQ, ADCY7, GNAS, GNAS

GO:0007190

BP

activation of adenylate cyclase activity

Any process that initiates the activity of the inactive enzyme adenylate cyclase.

ADCY3, ADCY9, RAF1, ADRB2, ADRB1, ADRB3, PRKCA, LHCGR, FSHR, EDNRA, ADORA2B, AVPR2, ADCY7, CALM2

GO:0007191

BP

adenylate cyclase-activating dopamine receptor signaling pathway

The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).

GNB1, GNAS, GNAS

GO:0007192

BP

adenylate cyclase-activating serotonin receptor signaling pathway

The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).

HTR7

GO:0007193

BP

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).

GPR37, ADCY3, ADCY9, GNAI2, PSAP, GNAI3, NPR3, S1PR1, NPY1R, HTR2C, ADORA1, OPRL1, HTR2B, NPY2R, ADCY7, GNAI1, S1PR3, GABBR1

GO:0007194

BP

negative regulation of adenylate cyclase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.

GABBR2, GNAI2, GNAI3, DRD2, PRKCA, GRM3, GABBR1

GO:0007195

BP

adenylate cyclase-inhibiting dopamine receptor signaling pathway

The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).

DRD2, FLNA

GO:0007196

BP

adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).

GRM8, GRM6, GRM3

GO:0007197

BP

adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).

CHRM2, CHRM3, HRH3

GO:0007199

BP

G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP).

AGT, AGTR2

GO:0007200

BP

phospholipase C-activating G-protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).

GPR32, AGT, ESR1, NPR3, FPR1, C5AR1, LHCGR, CXCR2, FPR2, ADRA1D, F2R, HTR2C, AGTR1, CCKBR, ADRA1A, HRH1, ADRA1B, HTR2B, PTGER3, GNB1, KISS1R

GO:0007202

BP

activation of phospholipase C activity

The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

EGFR, AGT, ANG, SELE, C5AR1, EDNRA, ADRA1A, ADCYAP1R1, HTR2B, GNAQ, PRKCD

GO:0007204

BP

positive regulation of cytosolic calcium ion concentration

Any process that increases the concentration of calcium ions in the cytosol.

JAK2, GPR32, LRP6, AGT, KNG1, ESR1, EDN1, CD55, NMB, HMGB1, SAA1, PDGFRA, CD36, GJA1, EDN2, FPR1, C5AR1, CXCR2, CD24, FPR2, ADRA1D, EDNRA, F2R, AGTR1, OXTR, CCKBR, ADM, ADRA1A, ADRA1B, PTGER4, OPRL1, ABL2, PTGFR, PTGER3, PTGER2, PIK3CG, NPY2R, BCAP31, F2RL1, CXCR4, GNB1, DLG4, PKD1, PTGDR, CACNA1C, ITPR3, SPPL3, TRPM4, S1PR3, GPER1, C1QTNF1, TRPV4, GHRL, TRPC6

GO:0007205

BP

protein kinase C-activating G-protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).

PLPP1, EDN1, CCK, GAP43, F2R, HTR2B, DGKZ, DGKK, DGKH, PARD3