GO:0035692

CC

macrophage migration inhibitory factor receptor complex

A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins.

CD74, CD44

GO:0035693

CC

NOS2-CD74 complex

A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases.

CD74

GO:0035748

CC

myelin sheath abaxonal region

The region of the myelin sheath furthest from the axon.

ITGB1, CNP, DLG1, EXOC4

GO:0035749

CC

myelin sheath adaxonal region

The region of the myelin sheath nearest to the axon.

ANXA2, CNP, MAG, PTEN, STX4, MPP5

GO:0035770

CC

ribonucleoprotein granule

A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.

HNRNPL, FXR1, HNRNPA3, GRSF1, DHX30, UHMK1, DDX28

GO:0035841

CC

new growing cell tip

A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth.

GRM6

GO:0035861

CC

site of double-strand break

A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

NBN, RNF8, H2AFX, MRE11A, VCP, RAD51, ESCO2, RFWD3, SLF2, SMC5, RNF169, RAD50, SMC6, SLF1, SMARCAD1, RAD18, PRPF19

GO:0035867

CC

alphav-beta3 integrin-IGF-1-IGF1R complex

A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits.

IGF1, ITGB3, ITGAV, IGF1R

GO:0035869

CC

ciliary transition zone

A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.

UNC119B, SEPT2, PCM1, TMEM107, C5orf30, CC2D2A, B9D1

GO:0035976

CC

transcription factor AP-1 complex

A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes.

DDIT3

GO:0035985

CC

senescence-associated heterochromatin focus

A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes.

HMGA1, HMGA2

GO:0036020

CC

endolysosome membrane

The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.

TLR3, AP2A2, CLTA, AP2S1, AP2B1, AP2M1

GO:0036021

CC

endolysosome lumen

The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.

CTSL, CTSB, CTSS, CTSK

GO:0036024

CC

protein C inhibitor-TMPRSS7 complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7.

SERPINA5

GO:0036025

CC

protein C inhibitor-TMPRSS11E complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E.

SERPINA5

GO:0036026

CC

protein C inhibitor-PLAT complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator.

SERPINA5

GO:0036027

CC

protein C inhibitor-PLAU complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator.

SERPINA5

GO:0036028

CC

protein C inhibitor-thrombin complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin.

SERPINA5

GO:0036029

CC

protein C inhibitor-KLK3 complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen.

SERPINA5

GO:0036030

CC

protein C inhibitor-plasma kallikrein complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein.

SERPINA5

GO:0036038

CC

MKS complex

A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.

AHI1, TCTN2, MKS1, CC2D2A, B9D1

GO:0036057

CC

slit diaphragm

A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.

IQGAP1, MAGI2, TRPC6, F11R

GO:0036064

CC

ciliary basal body

A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.

SSNA1, C21orf2, OFD1, RP2, EZR, TUBG1, AKT1, CENPF, RAB28, EVC, PKD2, PCM1, FAM161A, CFAP126, JADE1, BBS7, AHI1, POC1A, BBOF1, BBS1, TTC8, POC1B, PIFO, DYNC2LI1, IFT81, RPGR, KIFAP3, WDR34, MARK4, CEP19, FOPNL, BBS2, IFT122, CENPJ, CYLD, IFT46, MKS1, SPATA7, WDR35, WRAP73, INTU, B9D1, SSX2IP, DAAM1, FAM179B

GO:0036126

CC

sperm flagellum

A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.

DRD2, ATP2B4, MNS1, RPGR, AK8, SLIRP, IQCG, RNF38, DNAH1

GO:0036156

CC

inner dynein arm

Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.

DNAH1

GO:0036157

CC

outer dynein arm

Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.

DNAH5, DNAI1

GO:0036195

CC

muscle cell projection membrane

The portion of the plasma membrane surrounding a muscle cell projection.

ARPC2, PLEKHO1

GO:0036396

CC

MIS complex

An mRNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and WTAP.

WTAP, METTL14

GO:0036398

CC

TCR signalosome

A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology.

STK11

GO:0036449

CC

microtubule minus-end

The end of a microtubule that does not preferentially grow (polymerize).

FAM175B, ASPM, NIN

GO:0036457

CC

keratohyalin granule

A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope.

CELA2A

GO:0036464

CC

cytoplasmic ribonucleoprotein granule

A ribonucleoprotein granule located in the cytoplasm.

DYNC1I1, ROCK2, STAU1, RPLP0, TUBB, MAPT, RPL28, IQGAP1, ACTB, CDC42, RPS6, RAC1, HNRNPU, FMR1, TUBA1A

GO:0036477

CC

somatodendritic compartment

The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon.

RAB5A, STX4

GO:0036488

CC

CHOP-C/EBP complex

A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors.

CEBPB, DDIT3

GO:0036501

CC

UFD1-NPL4 complex

A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p.

UFD1L

GO:0036502

CC

Derlin-1-VIMP complex

A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome.

VIMP

GO:0036513

CC

Derlin-1 retrotranslocation complex

A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel.

VCP, SYVN1, SVIP, HM13, VIMP, SEL1L, AMFR

GO:0038039

CC

G-protein coupled receptor heterodimeric complex

A protein complex that contains two G-protein coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR.

GABBR2, GABBR1

GO:0042022

CC

interleukin-12 receptor complex

A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.

IL12RB1

GO:0042101

CC

T cell receptor complex

A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.

BCL10, CD4, CD6, SYK, ALCAM

GO:0042272

CC

nuclear RNA export factor complex

A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm.

ATXN1

GO:0042382

CC

paraspeckles

Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei.

NUDT21, SFPQ, HNRNPM, NONO, PSPC1

GO:0042383

CC

sarcolemma

The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.

FXYD1, FLOT1, PDE9A, ANXA1, ATP1B1, ITGB1, KRT8, ANXA2, KRT19, LAMP1, DMD, COL6A1, COL6A2, COL6A3, DES, VCAM1, BGN, SLC2A5, LAMA2, BSG, ANK2, PPP3CA, AHNAK, ANK3, DLG1, SNTA1, SNTB1, DAG1, FLNC, SSPN, SLMAP, RYR3, SGCB, BVES, SGCD, RYR2, SGCZ, CIB1, SYNC, FKRP, POPDC2, MYOT, PEMT, SLC27A6, DTNA

GO:0042405

CC

nuclear inclusion body

An intranuclear focus at which aggregated proteins have been sequestered.

NBN, TPR, NUP153, RANBP2, ATXN3, ATXN1, PABPN1, SLF1, RAD18, NXF1, STUB1

GO:0042406

CC

extrinsic component of endoplasmic reticulum membrane

The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

TOR1A

GO:0042470

CC

melanosome

A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.

RAB27B, SDCBP, TPP1, RAB29, CALU, SEC22B, FLOT1, ATP6V1G2, TFRC, ITGB3, ITGB1, P4HB, CTSD, ANXA2, CTSB, HSP90AA1, ANXA6, SLC3A2, HSP90AB1, CNP, HSPA5, SLC2A1, LAMP1, PDIA4, HSP90B1, TYR, RAB5A, ATP6V1B2, PPIB, AHCY, STOM, CANX, ERP29, PDIA3, YWHAB, BSG, MYH11, SERPINF1, CAPG, PMEL, SLC1A4, FASN, TMED10, MMP14, ANXA11, RAB5C, RAB9A, RAB27A, ATP1B3, NAP1L1, RAB2A, RAB5B, YWHAE, RAB1A, RAC1, YWHAZ, PRDX1, STX3, RAB32, GANAB, GPNMB, PDIA6, SLC1A5, MYRIP, PDCD6IP, GGH, ATP6V0A1, ANKRD27, SYTL2, HPS4, MYO5A, TRPV2

GO:0042555

CC

MCM complex

A hexameric protein complex required for the initiation and regulation of DNA replication.

MCM3, MCM4, MCM5, MCM7, MCM2, MCM6, TONSL

GO:0042564

CC

NLS-dependent protein nuclear import complex

A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore.

MYBBP1A

GO:0042567

CC

insulin-like growth factor ternary complex

A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development.

IGF1, IGFBP3, IGFBP5

GO:0042571

CC

immunoglobulin complex, circulating

An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.

IGLL5

GO:0042581

CC

specific granule

Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.

SNAP23, ANXA3, ANXA11, CLCN3, CRISP3, ADAM8, STX4, STX3, STXBP2, OLFM4

GO:0042582

CC

azurophil granule

Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.

SNAP23, STX7, MPO, HEXA, DEFA4, ANXA11, STX3, STXBP2

GO:0042583

CC

chromaffin granule

Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.

CLU

GO:0042584

CC

chromaffin granule membrane

The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.

SYT1, SRI

GO:0042585

CC

germinal vesicle

The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity.

AURKA, MARCKS

GO:0042587

CC

glycogen granule

Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface.

PPP1R3D, FASN, PCYT1A, PPP1CA, PPP1CB, PPP1R3B

GO:0042588

CC

zymogen granule

A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.

GNAI3, SRGN, HSPD1

GO:0042589

CC

zymogen granule membrane

The lipid bilayer surrounding a zymogen granule.

RAB27B, SCAMP1, TMED10, VAMP2, STX3, TMED2, STXBP2, DMBT1

GO:0042599

CC

lamellar body

A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome.

SFTPC

GO:0042612

CC

MHC class I protein complex

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

HLA-B, HLA-E, HLA-G, HLA-A, HLA-F, B2M, MR1

GO:0042613

CC

MHC class II protein complex

A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.

HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, HLA-DRB4, HLA-DOB, HLA-DPA1, HLA-DMB, HLA-DRB3, HLA-DRB5

GO:0042622

CC

photoreceptor outer segment membrane

The membrane surrounding the outer segment of a vertebrate photoreceptor.

DHRS3, OPN1SW, CNGA1, GNB1, NAPEPLD, PHLPP2

GO:0042627

CC

chylomicron

A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues.

APOA1, APOE, APOA2, APOC1, APOC3, APOH, APOB, LPL, APOBR, APOA5, LSR

GO:0042629

CC

mast cell granule

Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase.

SNAP23, PIK3CD, ANXA1, LYN, SRGN, KIT, AKR1B1, CXCR2, PIK3CG, CPLX2, NR4A3, S100A13

GO:0042641

CC

actomyosin

Any complex of actin, myosin, and accessory proteins.

MYH9, HDAC4, DBN1, CDC42BPA, KAT2B, MYO5A, CDC42BPB

GO:0042643

CC

actomyosin, actin portion

The actin part of any complex of actin, myosin, and accessory proteins.

ACTC1

GO:0042645

CC

mitochondrial nucleoid

The region of a mitochondrion to which the DNA is confined.

KIAA0391, CLPX, SLC25A5, DBT, MPG, LRPPRC, VDAC2, ACADVL, DNA2, POLG, HADHB, TFAM, SSBP1, GRSF1, DHX30, SUPV3L1, TEFM, PEO1, MTERF1, ELAC2, UQCC2, DDX28, ATAD3A, POLDIP2

GO:0042719

CC

mitochondrial intermembrane space protein transporter complex

Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane.

TIMM10B

GO:0042734

CC

presynaptic membrane

A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.

APBB1, GRM8, CASK, GRM6, FBXO45, FOSL1, SYT1, ADORA1, SNAP25, FMR1, KCNA1, GRIN2A, STX3, PICALM, GRM3, NECTIN1, ERC1, ZDHHC17, DENND1A, KCTD12, GPER1, GABBR1, NRXN1, RIMS2, SNCAIP

GO:0042765

CC

GPI-anchor transamidase complex

An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor.

PIGK, PIGT, PIGU

GO:0042788

CC

polysomal ribosome

A ribosome bound to mRNA that forms part of a polysome.

EEF2, NR0B1, RPL7A, FMR1, NUFIP2

GO:0042824

CC

MHC class I peptide loading complex

A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.

CALR

GO:0042827

CC

platelet dense granule

Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins.

HPS4

GO:0042995

CC

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

SH3PXD2B, ANGPT2, TLR2, LPXN, WDR1, CLSTN1, SPP1, ACTN1, EZR, MDK, RRM1, CAD, GJA5, AGFG1, ARPC4, PTEN, ACTR2, GTF2I, FMR1, ARHGEF5, TRIP10, SCN9A, KIZ, RHOU, CFAP52, ARHGAP24, CFAP36, MEGF10, MAGI1, RTN4, CDC42SE2, BIN2

GO:0043005

CC

neuron projection

A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

SNAP23, ARPC2, FLRT2, SIAH2, ACTN4, PARK2, KIF5C, KIF1B, DAB1, GABBR2, MYO1D, UNC5C, FOS, GPI, TH, PFN1, HSP90AA1, NGFR, VIM, NMB, QDPR, PTPRF, MAP2, FOSL1, STMN1, ATF4, PAM, SYT1, CALB2, AHCY, ATP2B4, MPST, FAS, S100A4, CD27, SLC6A1, SSTR1, GDI1, NF2, SSTR5, PTGS2, OPRL1, RGS2, ADCYAP1R1, SLC1A3, IQGAP1, NPBWR1, CSNK1D, STAR, HNMT, VAMP7, HNRNPA3, CDH13, PTEN, RAC3, SNAP25, CDC42, RAP1A, VAMP2, CXADR, ABAT, ARF1, CDK16, ANK2, APBA1, FMR1, GRIN2A, ANK3, FADD, STX3, CLN3, HDAC1, ARHGEF7, CASP8, KISS1, NPY5R, NCOA1, ITSN1, VAMP3, PTPRO, CPEB4, SLC4A8, TENM4, KLC3, NSMF, SV2A, SV2B, CYFIP1, RASGRP2, CPEB2, TPH2, CPEB3, CYGB, ANKS1A, NRCAM, GHSR, FGF13, RAB39B, CYFIP2, PDLIM5, MARK4, PACRG, DOCK7, ANKRD27, CIB1, INPP5K, CADM1, LIN7B, CACYBP, ATP13A2, LIN7C, STMN3, TENM3, MYO5A, LSM4

GO:0043020

CC

NADPH oxidase complex

A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2.

CYBB, NCF2, NCF4, NOXA1, NOX4

GO:0043025

CC

neuronal cell body

The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

APBB1, AGRP, ENC1, NRP1, PMM2, SLC31A1, SIAH2, RGS10, BRINP1, ACSL4, COBL, ZPR1, SRSF10, DAB1, LRP6, MYO1D, STAU1, ADA, CST3, TGFB1, PENK, APOE, ANG, APOB, S100B, TUBB4A, NTRK1, CYBB, APOD, CYP17A1, INHA, HSP90AA1, CHRM2, UCHL1, C4A, PTPRF, IAPP, LAMP1, ANXA3, NQO1, TIMP2, CPE, SRD5A1, ELK1, TNFRSF1B, RAB5A, FLNA, GAL, RRM1, CAD, CANX, EPHB2, ADORA1, SRD5A2, PRKAR2B, BMPR1A, IL6ST, SLC1A3, SLC1A4, CSNK1E, STAR, PSEN1, PSEN2, GSK3B, ASCL1, PPT1, AGFG1, EPHA5, RAC3, CDC42, TGFB2, RACK1, GTF2I, CDK5, PURA, DHODH, FKBP4, EEF1A2, SOS1, KCNA1, TIAM1, STRN3, MAPK8IP2, ILK, PICALM, TUBB3, CAMK2D, ALCAM, BMPR2, ARHGEF7, ITPR3, KCNJ11, PTPRK, CNN3, KISS1, ASIC2, DPYSL2, FBXO31, CPLX2, KNDC1, CAMK2N1, TRPV1, DNER, TRPM4, DENND1A, PARD3, CYGB, ARHGEF2, ALS2, P2RX4, TXN2, OLFM1, CIB1, KATNB1, SPTBN4, PHAX, ATP13A2, GLRX2, ELOVL5, CRIPT, ATXN10, PPARGC1A, VTI1B, PTBP2, ADAM21, AMFR, NRXN1, PYCARD, IGSF9B, MYO5A, RBM8A, SNCAIP

GO:0043033

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isoamylase complex

A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages.

AGL

GO:0043034

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costamere

Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix.

KRT8, KRT19, DMD, SDC4, FXR1, ANK2, AHNAK, ANK3, ILK, DAG1, FLNC, HOMER1

GO:0043083

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synaptic cleft

The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.

PRSS12, COLQ

GO:0043159

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acrosomal matrix

A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction.

DLD

GO:0043186

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P granule

A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.

PIWIL4, TDRD9, CARHSP1

GO:0043190

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ATP-binding cassette (ABC) transporter complex

A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.

ABCD4, ABCG8, ABCB6, ABCF2

GO:0043194

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axon initial segment

Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.

BIN1, CCK, ANK3, CAMK2D, NRCAM, SPTBN4

GO:0043195

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terminal bouton

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.

AP3D1, SYNJ1, STX6, GHRH, APP, CCK, TH, SYN1, RAB5A, SYT1, CALB2, CAD, ADORA1, SNCA, NMU, RAB7A, POLG, PRSS12, STXBP1, AP1S1, SLC18A2, ILK, DPYSL2, NTRK2, AAK1, CPLX2, SV2A, AP2M1, P2RX4

GO:0043196

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varicosity

Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.

TNFRSF1B

GO:0043197

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dendritic spine

A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including thin, stubby, mushroom, and branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.

APBB1, RGS10, CTNND1, CRYAB, APP, ITGB1, DRD2, ARF4, NR1D1, COMT, ITPKA, LAMA2, MT3, CANX, ADORA1, PRKAR2B, ACTN2, PPP1CC, MAP1B, ATP1A2, FXR1, EPHA4, PTEN, PPP1CA, DLG4, MYL7, FMR1, STX4, TIAM1, MTMR2, CTTN, GRM3, FRMPD4, CNN3, ASIC2, PTPRO, ARC, NLGN1, ALS2, P2RX4, SYT11, STRN4, CRIPT, ASAP1, LZTS1, FARP1, ARFGEF2

GO:0043198

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dendritic shaft

Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.

APP, FLNA, PRKAR2B, NSF, PSEN1, GSK3B, ILK, NLGN1, ARHGEF2, SYNGAP1, GPER1, CRIPT, LZTS1

GO:0043202

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lysosomal lumen

The volume enclosed within the lysosomal membrane.

RNASET2, MAN2B1, NCAN, TPP1, GYG2, SDC3, GPC4, CSPG5, GC, FUCA1, CD74, HEXA, CTSD, DCN, PSAP, CTSL, HSP90AA1, PDGFRB, GAA, LAMP2, VCAN, ARSA, GNS, ARSB, GM2A, SDC1, OGN, BGN, CTSS, SDC4, GALNS, SDC2, GPC1, PPT1, SGSH, LUM, NAGLU, GALC, HSPG2, FMOD, ASAH1, CSPG4, GPC2, BCAN, NEU1, OMD, ATP13A2, CTSF, PPT2, HPSE, MAN2B2, GPC6

GO:0043203

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axon hillock

Portion of the neuronal cell soma from which the axon originates.

AURKA, CCK, SERPINF1, NDEL1, SPTBN4, TPX2

GO:0043204

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perikaryon

The portion of the cell soma (cell body) that excludes the nucleus.

KCNK1, ZPR1, PDE9A, GOT2, ASS1, GNRH1, PENK, CRYAB, BGLAP, CCK, TH, ENO2, TOP1, CCL2, DRD2, PAM, MAPK1, FUS, EPHA4, PPP1CA, RACK1, CDK5, FMR1, KCNA1, KLHL24, NSMF, RUFY3, SIRT2, OLFM1, NGB, HDAC6

GO:0043205

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fibril

Extracellular matrix material consisting of polysaccharides and protein.

SNCA, SLC1A3, MUC5AC

GO:0043209

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myelin sheath

An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.

PHGDH, TSPAN2, WDR1, SLC25A12, TPPP, MYO1D, NDUFA10, GOT2, CA2, CRYAB, PMP2, ALB, TUBB4A, ERBB2, ATP1B1, SLC25A5, GPI, LDHB, HSP90AA1, PDHA1, ENO2, DLD, UCHL1, BCL2, DLAT, HSPD1, HSPA5, RALA, NEFH, SLC25A4, CKB, MIF, PKM, EZR, SYN1, TCP1, SRD5A1, NDUFV2, COX5A, ATP6V1B2, NME2, UQCRC2, CANX, NDUFS1, TKT, PDIA3, SDHA, GDI1, UQCRC1, STIP1, PHB, RDX, ATP5C1, DLST, MDH1, MDH2, VDAC2, NSF, UQCRFS1, CCT3, GDI2, ATP1A2, VCP, PLP1, ACTB, SNAP25, CDC42, STXBP1, RAP1A, GNB1, GNB2, RPS27A, ACTG1, TUBA1B, TUBB4B, CCT2, PITPNA, SLC25A3, EEF1A2, PRDX1, CNTN1, ITPR3, KCNJ11, SEPT2, DPYSL2, FSCN1, TUBA1A, SERINC5, SIRT2, CA13, PDCD6IP, NDRG1, CNRIP1, ACO2, PACSIN1, PLCB1, EHD3, SUCLA2

GO:0043218

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compact myelin

The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs.

PMP22

GO:0043219

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lateral loop

Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode.

STX4, DLG1, SIRT2, MPP5

GO:0043220

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Schmidt-Lanterman incisure

Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier.

ANXA2, AKR1B1, MAG, PRKCI, PTEN, SIRT2, MPP5, JAM3

GO:0043224

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nuclear SCF ubiquitin ligase complex

A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

RBX1

GO:0043231

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intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

CNOT1, AGPS, HIP1, ARNTL, IPO5, CHD2, ADAM10, CHEK1, MGST3, XPO1, BTAF1, SCAMP1, SCAMP2, STX7, P4HA2, SIAH2, AQP9, SLC25A17, FADS1, RAD1, DIAPH2, RAB11FIP3, PEX14, VPS26A, ECI2, DAB1, STAM2, URI1, SEC31A, GDF11, PPP1R3D, CYB5A, AMBP, TFRC, APOB, S100B, GAPDH, CYP1A1, APP, UGT2B4, INSR, CTSB, IGF1R, COL4A2, CYP3A4, STS, CLTA, G6PD, CYP2C9, VCAN, P4HA1, POU2F1, LIG1, ATP2B1, CYP3A5, ATP6V1B2, CNR1, FGFR2, SCP2, PTGS1, ME2, ATP2B4, PTAFR, MCM3, CTSS, PSMA4, PON1, ABCD3, GRN, CTGF, TSPO, ALDH1B1, FOXN2, STX2, CTNNA1, GTF2F1, IRS1, PSMC2, NUP62, PPARG, DDOST, ELK3, EPS15, RANGAP1, ARCN1, PRRC2A, ATP1A2, RAB5C, RAB7A, NOVA1, SMARCA2, ALDH3A2, HSD17B4, PLXNA3, VAMP7, AGFG1, MSH6, ATXN1, ATP12A, VCP, SEC13, POLE2, AP1S2, PEX3, AP3S2, AP1S1, NCS1, AP2B1, VAMP2, YBX1, OLR1, GPLD1, SARNP, DAB2, RUNX1, SLC7A5, COL4A3, MEF2C, CHAF1A, CALCOCO2, IFIT5, MTA1, SLC14A1, GOLGA4, TRA2A, SNX1, PTCH1, VEZF1, CTTN, GRB14, MEF2D, ZNF638, ACOX1, NECTIN1, RABEP1, TMED2, PCBP1, TAF5, TAF1C, TAF1A, TRIP10, NSDHL, VAMP3, USF2, ZFHX3, SNAPC1, CYP1B1, TBRG1, ATP13A5, KLHL12, ZNF326, ACBD5, FAM72A, LAMTOR1, FAM72D, SFXN4, AGTRAP, AFTPH, PARM1, UGT2A3, DRAM2, RAB11FIP1, RAB11FIP2, ZFYVE16, WAPL, ARHGAP30, RABEPK, CASZ1, ALYREF, SLC26A11, OSTM1, GPBP1, FAM72B, PPP1R3B, TDRP, DCP2, ZDHHC17, SLF2, KMT2E, RDH10, ABCA6, CA13, EIF1AD, HSD17B11, LSM14A, TNRC6A, PHC3, VPS37A, NUP35, GPRC5A, DBF4B, MFSD8, SPATA18, SPPL3, SPPL2A, ABHD5, SCARB1, MITD1, ABCA5, SLC9A6, GOLGA1, ATP6V0A1, KISS1R, PMEPA1, CLUAP1, MVB12A, ERO1A, SENP5, EAF1, SEC16B, EXOC2, PLIN4, SNX18, ERGIC2, CCNL2, ACOX2, NEU1, PLIN2, BARD1, LITAF, MGST2, MYBBP1A, DHRS4, TIPIN, CLEC7A, POLDIP3, ASPSCR1, TRIM8, EIF5A2, UBA5, UPF3A, OBFC1, ATP13A3, PHAX, DDX31, RRAGC, TMEM165, NEK6, ANLN, ACSS2, EIF4ENIF1, SNX15, GLRX2, TMEM106B, TDP1, NDFIP2, MTPAP, THAP1, AURKAIP1, SYBU, ZDHHC7, GPRC5B, GRHL1, DTL, GLTSCR2, KANSL3, DNMT3B, VPS29, CTSZ, POLK, AASS, VTI1B, KCNG1, GGA1, CROT, ZMIZ1, PLAGL1, PPT2, POLI, TRIM33, HPSE, RNF6, RUVBL1, ITM2B, GSTK1, CCDC53, TNPO3, XRCC6BP1

GO:0043234

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protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

APBB1, KRIT1, SMAD7, RIPK2, PRPF3, SMAD6, ACTN4, TRIAP1, KDM1A, MITF, PEX14, ERLIN2, SNX4, GDF11, MBD3, BCL10, PEX11B, ACTL6A, GOT2, MYC, RBP4, TTR, ALB, ANXA1, NR3C1, NTRK1, TP53, SERPINA5, KLK3, TUBB, HSP90AA1, HNRNPC, PARP1, AR, PRKAR1A, HSPD1, CLU, BCR, TOP2A, DMD, COL6A1, COL6A2, SKI, SKIL, CFTR, PDGFRA, ATP2A2, NPPB, SDC1, BCL3, CAPN3, HNF1A, SCP2, ATP2B4, HMGB2, MAPK3, CAD, CANX, MAPK1, CORO1A, GDI1, AKT1, STIP1, OTX2, CTNNB1, PTGS2, MYH9, PPP1CC, SREBF1, BRCA1, CDKN1A, DDOST, FEN1, PRKCI, HTT, SYK, IQGAP1, LIMS1, SOX9, NASP, CDK8, PPM1F, RGS4, PSEN2, SMARCA4, BRCA2, CAV2, NEK2, POLG, HIRA, MLLT10, SNU13, PEX3, NLRP5, ACTB, STXBP1, DCAF7, RAB11A, ACTA2, HIST1H4A, GNB2, HIST1H3D, CXADR, H3F3A, HSF1, MDM2, SPTBN1, SET, ID2, FKBP4, CAV1, PTPN11, MEF2C, RBBP4, STRN3, STK4, CHAF1A, CHAF1B, MAPK8IP2, UBE2V1, ILK, IKZF1, SNTA1, SNTB2, BIRC3, EIF4EBP1, HDAC1, SNX1, ACVR2B, SNTB1, CKAP5, ARHGEF7, RFTN1, LTBP1, CHD4, RAB3GAP1, PCM1, NR0B2, TAB1, SMAD1, PKN1, PKN2, DPYSL2, CDCA8, PTRF, CNST, RNF111, RNF165, PXK, MAGI2, SLC51A, WWC1, MPP5, CISD2, INADL, SMARCC2, PARD3, IPO4, PPM1E, RYR2, HDAC2, TANK, SMARCC1, ARHGEF2, PRKCDBP, DNAJC19, ALS2, PANX1, USP28, PHB2, SMAD5, SOST, AIF1L, CCM2, NAT9, SSBP3, PARD6B, FOXP3, CCDC113, RAB3GAP2, TLE6, PLEKHA2, CHD8, GOPC, PARD6A, SPATS2L, ASF1B, TES, NUFIP1, AMFR, MYH2, NRXN1, KIDINS220, MYO5B, HIGD1A, PRELID1, ASF1A, EXOG, SSX2IP, SUGT1, PAM16, DTNA, WIPI2, N6AMT1

GO:0043235

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receptor complex

Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

NRP1, MUSK, GPR37, RAMP1, RAMP3, LRP5, LRP6, TM7SF2, EGFR, LDLR, ERBB2, NTRK1, APP, ITGB3, ITGB2, ITGB1, INSR, ADRB2, IGF1R, GHR, FGFR1, VDR, ADRB3, ITGB4, ITGB5, ERBB3, PTPRB, IL4R, ITGA3, KLRC1, ACVR2A, FLT4, ACVR1B, TGFBR1, TGFBR2, ADCYAP1R1, LIFR, NOTCH1, MTNR1A, LEPR, TRPC1, OLR1, SMAD3, VLDLR, LRP2, ROR1, TGFBR3, NOTCH2, DDR1, NR1H3, RIPK1, ACVR2B, ITPR2, ITPR3, ERBB4, TRADD, NTRK2, NT5DC3, ITLN1, GPR98, LOXL4, GPR63, ABCG8, GPRC5C, GPR160, TAOK2