GO:0043240

CC

Fanconi anaemia nuclear complex

A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage.

STRA13, FANCG, FAAP100, FAAP20, FANCM, APITD1, FANCB, FANCE

GO:0043257

CC

laminin-8 complex

A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains.

LAMB1

GO:0043259

CC

laminin-10 complex

A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains.

LAMB1, LAMC1

GO:0043260

CC

laminin-11 complex

A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains.

LAMC1

GO:0043265

CC

ectoplasm

Granule free cytoplasm, lying immediately below the plasma membrane.

GYS2

GO:0043292

CC

contractile fiber

Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

PPP1R12A, CST3, GJA1, DEK

GO:0043293

CC

apoptosome

A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms.

CASP9

GO:0043296

CC

apical junction complex

A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.

CCDC85C, RHOA, TJP1, PKN2, FBF1, SHROOM3, FRMD6, NECTIN3

GO:0043509

CC

activin A complex

A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A).

INHBA

GO:0043512

CC

inhibin A complex

Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit.

INHA, INHBA

GO:0043513

CC

inhibin B complex

Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit.

INHA

GO:0043514

CC

interleukin-12 complex

A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.

IL12A

GO:0043540

CC

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex

A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.

PFKFB1

GO:0043541

CC

UDP-N-acetylglucosamine transferase complex

A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis.

EXT2

GO:0043564

CC

Ku70:Ku80 complex

Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK.

XRCC5

GO:0043596

CC

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

SMARCA5, PCNA, ZMIZ2, TONSL, SMARCAD1, BAZ1B

GO:0043614

CC

multi-eIF complex

A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.

EIF2S1, EIF3A

GO:0043625

CC

delta DNA polymerase complex

A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair.

POLD1, POLD3, POLD4

GO:0043626

CC

PCNA complex

A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.

PCNA

GO:0043657

CC

host cell

A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope.

DYNLT1

GO:0043679

CC

axon terminus

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.

HNRNPR, RGS10, SRSF10, GNRH1, PENK, CHRM2, CCL2, DRD2, ITGA2, ELK1, CHRM3, RAB5A, SRI, NTS, EPHA4, ATP6V0D1, FMR1, KCNA1, SEPT6, SLC9A6, GPER1, PACSIN1, FLRT3

GO:0044194

CC

cytolytic granule

A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.

LAMP1, STXBP2, RNF19B

GO:0044207

CC

translation initiation ternary complex

A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).

EIF2S1

GO:0044214

CC

spanning component of plasma membrane

The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.

BMPR2, CDHR2

GO:0044216

CC

other organism cell

A cell of a secondary organism with which the first organism is interacting.

C4A, C4B

GO:0044224

CC

juxtaparanode region of axon

A region of an axon near a node of Ranvier that is between the paranode and internode regions.

DLG4, KCNA1, SIRT2, EPB41L3

GO:0044232

CC

organelle membrane contact site

A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.

ESYT2, ESYT1

GO:0044233

CC

ER-mitochondrion membrane contact site

A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange.

ACSL4, CANX, RAB32, TOMM20, ZFYVE1

GO:0044291

CC

cell-cell contact zone

Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle.

FLOT1, RAP2B, AHNAK, TIAM1, FLCN, PKP4, JAM3, PCDH9

GO:0044294

CC

dendritic growth cone

The migrating motile tip of a growing nerve cell dendrite.

COBL, PTCH1, MAPK8IP1

GO:0044295

CC

axonal growth cone

The migrating motile tip of a growing nerve cell axon.

COBL, EPHA4, FKBP4, TIAM1, PTCH1, PARD3, OLFM1, FLRT3, MAPK8IP1, TRPV2

GO:0044297

CC

cell body

The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.

TLR2, STAU1, GNAI2, TUBB, MAPT, EZR, GNB3, TCP1, COMT, NF2, RPL28, CCT3, GNAQ, CCT8, ACTA2, RPS6, GNB1, GNB2, ACTG2, ACTC1, CXADR, CCT2, NRG1, FADD, DPYSL3, CASP8, RDH10, PACRG, CCT7, SYT11, PINK1, GABARAPL1, CACYBP, MAPK8IP1, LZTS1, TRPV2

GO:0044299

CC

C-fiber

The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated.

CCL2

GO:0044300

CC

cerebellar mossy fiber

An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as mossy appearance in Golgi stained preparations.

NFIB, DLG4

GO:0044302

CC

dentate gyrus mossy fiber

Distinctive, unmyelinated axons produced by granule cells.

MAPK8IP1

GO:0044304

CC

main axon

The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites.

APBB1, APP, TIAM1

GO:0044306

CC

neuron projection terminus

The specialized, terminal region of a neuron projection such as an axon or a dendrite.

SCRG1, MME, UCHL1, DMD, VAMP2, DLG4, TMEM57, FLRT1

GO:0044308

CC

axonal spine

A spine that originates from the axon, usually from the initial segment.

EEA1, SLC9A6

GO:0044309

CC

neuron spine

A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.

DLG4

GO:0044322

CC

endoplasmic reticulum quality control compartment

A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins.

OS9, SYVN1, RHBDD1, EDEM1, EDEM3, DERL2, UGGT1, SEL1L, MAN1B1

GO:0044326

CC

dendritic spine neck

Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine.

SRI

GO:0044327

CC

dendritic spine head

Distal part of the dendritic spine, that carries the post-synaptic density.

FUS, GPER1

GO:0044354

CC

macropinosome

A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.

ANXA2, CLIP1, MMP14, LRRC16A, ANKFY1

GO:0044393

CC

microspike

A dynamic, actin-rich projection extending from the surface of a migrating animal cell.

EZR, FSCN1

GO:0044530

CC

supraspliceosomal complex

Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing.

RBMX

GO:0044599

CC

AP-5 adaptor complex

An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo.

AP5Z1

GO:0044609

CC

DBIRD complex

A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD.

ZNF326, CCAR2

GO:0044611

CC

nuclear pore inner ring

A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex.

NUP155, NUP205

GO:0044613

CC

nuclear pore central transport channel

The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.

NUP62, NUP153, NUTF2, NUP35, NUP62CL

GO:0044614

CC

nuclear pore cytoplasmic filaments

Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component.

RANGAP1, RANBP2

GO:0044615

CC

nuclear pore nuclear basket

A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component.

TPR, NUP153, RANBP2, NUP35

GO:0044666

CC

MLL3/4 complex

A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species.

KDM6A, RBBP5, KMT2C, PAGR1, ASH2L

GO:0044753

CC

amphisome

An autophagosome formed upon fusion between autophagosomes and endosomes.

SQSTM1

GO:0044754

CC

autolysosome

A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases.

FTL, FTH1, LAMP2, SQSTM1, NCOA4, PIK3C3, MAP1LC3A

GO:0044798

CC

nuclear transcription factor complex

A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

KLF4, SOX15, SOX9, SOX8, SOX4, NFATC2, SOX17

GO:0044853

CC

plasma membrane raft

A membrane raft that is part of the plasma membrane.

MYO1D, PRKAR1A, PRKAR2A, EZR, PRKACA, CDH2

GO:0045025

CC

mitochondrial degradosome

A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.

SUPV3L1, PNPT1

GO:0045092

CC

interleukin-18 receptor complex

A protein complex that binds interleukin-18; comprises an alpha and a beta subunit.

TOLLIP

GO:0045095

CC

keratin filament

A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins.

KRT1, KRT18, KRT8, KRT7, KRT3, KRT13, CSNK1A1, KRT80, FAM83H, FBF1, GPER1

GO:0045098

CC

type III intermediate filament

A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments.

UPP2

GO:0045111

CC

intermediate filament cytoskeleton

Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.

TACC1, PSMD10, VIM, KRT13, DES, NES, CCT8, SMARCA2, FAAP100, NFATC4, PKN2, PHLDB2, XRN1, EIF1AD, NUP35, SYNE2, SEC62, OBFC1, MDN1, NFKBIL1, IP6K2, SAP30BP, STUB1, NSFL1C, ZNF175

GO:0045120

CC

pronucleus

The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.

AURKA, HNRNPL, CENPF, HSF1, EZH2

GO:0045121

CC

membrane raft

Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.

MYO1C, SDCBP, SYNJ2, NPC1, PLSCR1, CFLAR, DAPK3, TLR2, JAK2, FLOT1, ERLIN2, ABCA1, BCL10, EGFR, PGK1, KRAS, TNF, CD4, PRNP, GNAI2, APP, ICAM1, ITGB1, FYN, LDHB, CTSD, ANXA2, LYN, CD55, CD14, PTPRC, GNAI3, CD48, FURIN, HSPD1, DMD, TDGF1, EEF2, SLC2A4, PECAM1, SELE, CD36, RHOQ, GJA1, HK1, ATP2B1, TNFRSF1B, RAB5A, MAL, S1PR1, CNR1, CD24, FAS, STOM, DPP4, PPP2R1B, PRKAR2B, SDC4, GPC1, BSG, TGFBR1, TGFBR2, CSK, IQGAP1, PSEN1, SERPINH1, PPT1, CAV2, EPHB1, EMP2, S100A10, RAP2B, GNAI1, CXADR, OLR1, ADAM17, ANK2, TEK, CAV1, AHNAK, BST2, CNTN1, HYAL2, DLG1, MALL, FADD, CBLB, CLN3, BIRC3, GPM6B, RIPK1, DAG1, RFTN1, CASP8, ANGPT1, TLR1, TRADD, RFTN2, LAMTOR1, RGMB, PTRF, RTN4RL1, SULF1, UNC5B, ITLN1, TNR, INPP5D, GHSR, MAL2, EFHD2, MYADM, ARID3A, SORBS1, SMURF2, PAG1, GPRC5B, HPSE, PIKFYVE, ADGRG1

GO:0045160

CC

myosin I complex

A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement.

MYO1C

GO:0045171

CC

intercellular bridge

A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.

CDC7, RAB11FIP3, TDP2, ESRRA, BCL3, XPA, PRKCI, PIK3CB, TIRAP, KIF23, UNC119, CEP55, CDCA8, TEX14, KMT2E, PPP1R13L, AURKB, EAF1, C9orf72, C12orf66, SNRNP25, PCIF1, SRA1, FAN1

GO:0045177

CC

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

CHL1, DAB1, AQP8, PLAT, CA2, LDLR, APP, MGST1, EZR, VCAM1, ATP6V1C1, C5AR1, TUBG1, CTNNB1, NF2, SLC11A2, NUMB, CLCN5, VAMP7, EMP2, CDC42, GPSM2, ACVR1, TJP1, IFIT5, ITPR3, HFE, HOMER1, DYNC2LI1, PARD6B, EPB41L4B, PARD6A, MYO6

GO:0045178

CC

basal part of cell

The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.

TF, EDN1, ITGA2, SLC11A2, HFE, DOCK7, HOMER3

GO:0045179

CC

apical cortex

The region that lies just beneath the plasma membrane on the apical edge of a cell.

GM2A, NLRP5, HAMP, MYO5B

GO:0045180

CC

basal cortex

The region that lies just beneath the plasma membrane on the basal edge of a cell.

PKD2, PHLDB2, PHLDB1

GO:0045202

CC

synapse

The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

KCNK1, APBB1, RGS12, ARPC2, FLRT2, LRP6, UNC5C, SNAPIN, EGFR, APP, PFN1, CHRM2, MME, ITGA5, C4A, C4B, CHRNB1, DMD, CCL2, CDH2, CHRM3, CALB2, MPST, HTR2B, MTHFR, VAMP7, VAMP2, DLG4, MDM2, FMR1, KCNA1, STX4, SNTB2, SNTB1, SEPT2, ITSN1, VAMP3, CPEB4, SDK2, PDZD11, SARM1, CBLN3, NSMF, DNMBP, SHISA6, CYFIP1, RASGRP2, SDK1, CPEB2, MAGI2, ERC1, NLGN4X, SPG20, NLGN1, TMEM57, ENAH, CPEB3, MYRIP, GPR98, SLC9A6, SYN2, NRCAM, APBB2, CYFIP2, OLFM1, PRRT1, SH3GL2, PACSIN1, CADM1, NRN1, CBLN4, NDE1, DACT1, SAMD4A, MAPK8IP1, DLGAP4, DTNA, PCLO

GO:0045203

CC

integral component of cell outer membrane

The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

FAM73A

GO:0045211

CC

postsynaptic membrane

A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.

APBB1, DLGAP1, MUSK, LZTS3, GABBR2, CLSTN1, CHRM2, FBXO45, CHRNB1, BCR, DMD, CHRM3, COMT, CBLN1, F2R, CHRNA5, ADORA1, GABRA5, CHRNA7, NSG1, GRIA4, GLRB, EPHA4, PTEN, NCS1, DLG4, ARF1, CDK5, ANK2, FMR1, GRIN2A, ANK3, DLG1, PICALM, DAG1, SSPN, GRM3, NTRK2, COL13A1, NSMF, ARC, CAMK2N1, LRRTM4, HOMER1, ABI1, NLGN4X, NLGN1, MINK1, ATAD1, TRPV1, CACNG8, KCTD12, PDLIM5, SIGMAR1, CLSTN2, LIN7B, MAGEE1, GOPC, NECTIN3, GPHN, HOMER3, LIN7C, PSD3, GABBR1, IGSF9B, LZTS1

GO:0045239

CC

tricarboxylic acid cycle enzyme complex

Any of the heteromeric enzymes that act in the TCA cycle.

FH

GO:0045252

CC

oxoglutarate dehydrogenase complex

A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).

DLD, DLST, OGDH

GO:0045254

CC

pyruvate dehydrogenase complex

Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).

PDHA1, DLD, DLAT, PDHB

GO:0045273

CC

respiratory chain complex II

A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.

SDHB, SDHC

GO:0045277

CC

respiratory chain complex IV

A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).

COX7B, COX7B2

GO:0045298

CC

tubulin complex

A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.

MAPT, TPT1, BICD1

GO:0045323

CC

interleukin-1 receptor complex

A protein complex that binds interleukin-1; comprises an alpha and a beta subunit.

IRAK1, TRIP6, TOLLIP

GO:0045334

CC

clathrin-coated endocytic vesicle

A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance.

SFTPC, MYO1E, LMBRD1, MYO6

GO:0045335

CC

phagocytic vesicle

A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

STX6, ABCA1, ITGAV, CD36, ITGB5, CORO1A, ANXA11, RAB7A, RAB9A, CLCN3, VAMP7, RAB11A, RAB31, RAB32, RAB11B, RAB8B, SYT11, RAB34, RAB22A, RAB23

GO:0046540

CC

U4/U6 x U5 tri-snRNP complex

A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.

PRPF3, PPIH, LSM8, SNRPB, SNU13, LSM3, LSM6, SNRPD2, SNRPN, PRPF31, ZMAT2, PRPF18, LSM2, LSM5

GO:0046581

CC

intercellular canaliculus

An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates.

DPP4, TJP1, MTDH

GO:0046658

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anchored component of plasma membrane

The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.

MFI2, EFNA1, GAS1, HYAL2, RGMB, RTN4RL1, ULBP3, ULBP2, RHBG

GO:0046696

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lipopolysaccharide receptor complex

A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens.

TLR4, BCL10, CD14, HSPD1

GO:0046930

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pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

TOMM40, BCL2, NUP62, VDAC2, BAX, VDAC3

GO:0048179

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activin receptor complex

A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed.

ACVR1B, ACVR1

GO:0048188

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Set1C/COMPASS complex

A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

RBBP5, ASH2L

GO:0048237

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rough endoplasmic reticulum lumen

The volume enclosed by the membranes of the rough endoplasmic reticulum.

VTN, EDN1, LRPAP1

GO:0048269

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methionine adenosyltransferase complex

A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules.

MAT2A, MAT2B

GO:0048471

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perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

TLR4, APBB1, CLIC1, EML1, CDK2AP1, DYNC1I1, ENPP3, PTGES, ITGB1BP1, AURKA, RAB29, NPC1, AXIN1, STX7, CTIF, RAD51C, ACTN4, TRIAP1, STX6, PARK2, SPAG9, BUB1B, CCNT2, LPXN, ATP9A, LDB3, COBL, OBSL1, DNAJB6, ZPR1, CLN5, DAB1, PRKRA, USP2, STC2, PDE9A, ALDH1A2, TPPP, PLEKHG5, SEC24D, SORBS2, TRIM37, SEC31A, SNAPIN, ABCA1, SLC2A10, AIFM1, BCL10, EGFR, CST3, TGFA, TFRC, TF, MT2A, S100B, GAPDH, ERBB2, MT1E, MT1F, CYBB, APP, APOD, ITGB1, KRT18, S100A6, EIF4E, ANXA2, CTSB, HSP90AA1, LAMB1, LYN, ANXA6, INHBA, ANXA4, INHBB, CNP, HMOX1, TRAPPC2, HSPA1A, HSPA1B, SPP1, CLU, LAMP1, IGF2R, CDK4, ODC1, CCL2, MT1G, PLA2G2A, HSP90B1, SLC2A4, TYR, AKR1B1, EZR, NME1, SELE, ATP2A2, PRKCA, ITGA2, SRD5A1, PAM, TNFRSF1B, RAB3B, BCL3, FLNA, ZP3, OSBP, NME2, CA4, PPIB, BDNF, MCM3, MT3, ITGA3, S100A4, HMGB2, PLN, STOM, CALR, PTPRM, CTGF, CDC25C, PRKAR2B, DNAJA1, YWHAB, GBP2, CTNNB1, NF2, FUS, CHI3L1, MAP2K2, SERPINF1, PPARG, SNCA, CDKN1A, ANP32A, PLA2G5, PTGDS, LRPPRC, ECE1, LIMS1, CSNK1D, SLC11A2, CENPF, PPM1F, PSEN2, TSC2, GSK3B, AGTR2, CDK7, FXR1, CAV2, VAMP7, PLA2G16, ATN1, EPHA5, VCP, CDH13, TPD52, MTPN, RAC3, SNAP25, RAB4B, NCS1, RAB11A, RPS6, RAP1A, GNB2, VAMP2, RACK1, MT1H, MT1X, ARF1, ARF5, SET, APBA1, FKBP4, CAV1, PRKCD, RAD51, FMR1, GALNT2, GALNT1, TWF1, AKAP13, KCNH2, RAB40B, CDC20, STX4, HYAL2, DLG1, TAF10, AKAP6, CALCOCO2, PAK2, MAD2L1, PLD1, MYO9B, PICALM, SERINC3, HDAC1, CAMK2D, TP53BP2, PTCH1, EIF4A2, MAP7, FAT1, CUL7, KIAA0101, SEPT2, RASA2, RYR3, SEC23A, TRIP10, PKN2, CDKN3, TPD52L1, HFE, WDR44, BSPRY, TWF2, RHBDD2, OLFM4, CYHR1, AATK, CYFIP1, MTDH, MAGI2, SERINC5, MEX3D, CHERP, WWC1, CCAR1, SIRT2, RASEF, VPS52, AGGF1, MT1M, CMYA5, GALNT4, PCSK9, SERBP1, MYRIP, INADL, PUM2, ZNF675, RNF128, SELM, NANOS1, NDRG1, GOLGA1, RAB8B, MAL2, OPTN, CYFIP2, BICD1, DOCK6, DGAT2, KIF20B, GSDMA, CDC5L, GPER1, PKP4, P2RX4, S100A13, COPS8, DOK1, CIB1, HEPH, CORO1B, INPP5K, NDFIP1, MLPH, PINK1, PACSIN1, ASPSCR1, RAB34, SLIRP, TOLLIP, GBP3, EHD4, TNKS2, DEF6, SYNC, CHODL, UPF2, ZFYVE1, MAGEE1, PNPLA8, NOX4, CYLD, UBQLN4, NDFIP2, FMN2, EHD3, FLRT1, VAPA, ATXN10, PI4KB, HDAC6, SPAST, VTI1B, LNPEP, MOSPD1, NOCT, AMFR, BAG5, APLN, MYO6, NDRG2, ANGEL1, FAF1, MAPK8IP1, LAMP3, RASD1, TNFSF13B, PIKFYVE, USP20, PTPN22, ARFGEF2, MAP3K4

GO:0048476

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Holliday junction resolvase complex

A protein complex that mediates the conversion of a Holliday junction into two separate duplex DNA molecules; the complex includes a single- or multisubunit helicase that catalyzes the extension of heteroduplex DNA by branch migration and a nuclease that resolves the junction by nucleolytic cleavage.

EME2, RAD51C, EME1

GO:0048786

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presynaptic active zone

A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.

SYN1, ADORA1, SV2A, ERC1, GPER1, RIMS4, NUFIP1, RIMS2

GO:0048787

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presynaptic active zone membrane

The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.

SYT11

GO:0048788

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cytoskeleton of presynaptic active zone

The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites.

PCLO

GO:0051233

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spindle midzone

The area in the center of the spindle where the spindle microtubules from opposite poles overlap.

AURKA, BUB1B, APP, PLK1, GEM, CDC42, UNC119, KIF14, CDCA8, CENPV, ARL8A, AURKB, KIF20B, PKP4, CDC6, RACGAP1, ARL8B

GO:0051286

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cell tip

The region at the end of the longest axis of a cylindrical or elongated cell.

EZR, RDX, RAB8B

GO:0055037

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recycling endosome

An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

WASH1, KCNK1, DYNC1I1, RAB29, STX7, SLC31A1, SLC31A2, TBC1D12, ATP9A, RAB11FIP3, FCHSD2, TNF, TFRC, TF, ITGB1, RAP2A, CFTR, TUBG1, USP6, AQP2, SLC11A2, RAB4B, RAB11A, EEA1, RABEP1, VAMP3, RAB11B, HFE, LDLRAP1, RAB11FIP1, TUBA1A, VPS52, COMMD1, SH3TC2, SORL1, SGK3, OPTN, GPER1, SYT11, ACKR4, TBC1D14, VTI1B, RABGEF1, TNIK, MYO5B, ATP11B, NISCH, MYO5A, ARFGEF2

GO:0055038

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recycling endosome membrane

The lipid bilayer surrounding a recycling endosome.

WASH1, SCAMP1, SCAMP2, RAB11FIP3, RAP2A, RAP2B, RAB11A, RAB11B, RAB12, SLC39A4, RAB11FIP2, RFFL, SLC9A6, NDRG1, PLEKHB2, EHD4, EHD3, ZDHHC2, LAMP5, ATP11B

GO:0060053

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neurofilament cytoskeleton

Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons.

NDEL1