GO:0033065

CC

Rad51C-XRCC3 complex

A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof.

RAD51C

GO:0033093

CC

Weibel-Palade body

A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses.

VWF, EDN1, ECE1, RAB27A

GO:0033116

CC

endoplasmic reticulum-Golgi intermediate compartment membrane

The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.

GOSR2, SURF4, SEC22B, F8, SERPINA1, TGFA, INS, CD55, F5, FOLR1, AREG, KDELR1, CSNK1D, TMED10, BCAP31, CTSC, RAB2A, GOLGA2, TMED2, MCFD2, SPPL3, PIEZO1, ERGIC1, VMP1, ERGIC2, ASPSCR1, RAB1B, SLC35C2, CTSZ, LAMP5, ERGIC3, TMED5, TMED3

GO:0033162

CC

melanosome membrane

The lipid bilayer surrounding a melanosome.

TH, TYR, RAB7A, RAB32, SLC45A2

GO:0033167

CC

ARC complex

A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.

DICER1

GO:0033176

CC

proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

ATP6V1D

GO:0033179

CC

proton-transporting V-type ATPase, V0 domain

A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring.

ATP6V0E1, ATP6V0D1

GO:0033180

CC

proton-transporting V-type ATPase, V1 domain

A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A.

ATP6V1B2, ATP6V1C1, ATP6V1F, ATP6V1C2

GO:0033185

CC

dolichol-phosphate-mannose synthase complex

A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively.

DPM3

GO:0033186

CC

CAF-1 complex

A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48.

RBBP4, CHAF1A, CHAF1B

GO:0033193

CC

Lsd1/2 complex

A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast.

TAL1

GO:0033256

CC

I-kappaB/NF-kappaB complex

A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm.

NFKB1, RELB, RELA, REL

GO:0033257

CC

Bcl3/NF-kappaB2 complex

A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription.

BCL3

GO:0033263

CC

CORVET complex

A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p.

VPS8

GO:0033268

CC

node of Ranvier

An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.

BIN1, ANK3, DLG1, DAG1, SPTBN4

GO:0033269

CC

internode region of axon

An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath.

TUBB4A, PARD3

GO:0033270

CC

paranode region of axon

An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath.

MAG, KCNA1, ANK3, SIRT2, SPTBN4, KIF13B, EPB41L3

GO:0033276

CC

transcription factor TFTC complex

A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity.

SUPT3H, TADA3, TAF10, TAF5, TAF12, TAF9B, TRRAP

GO:0033290

CC

eukaryotic 48S preinitiation complex

A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.

EIF3J, EIF2S1, EIF3B, EIF3A, EIF3K

GO:0033291

CC

eukaryotic 80S initiation complex

A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region.

RPL38

GO:0033391

CC

chromatoid body

A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).

ARNTL, EIF4E, NSUN2

GO:0033503

CC

HULC complex

A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2.

UBE2A, UBE2B

GO:0033565

CC

ESCRT-0 complex

A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals.

STAM2, STAM

GO:0033588

CC

Elongator holoenzyme complex

A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes.

IKBKAP, ELP6, ELP4, ELP3

GO:0033593

CC

BRCA2-MAGE-D1 complex

A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth.

BRCA2

GO:0033596

CC

TSC1-TSC2 complex

A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.

TSC2

GO:0033597

CC

mitotic checkpoint complex

A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20.

BUB3

GO:0034045

CC

pre-autophagosomal structure membrane

A cellular membrane associated with the pre-autophagosomal structure.

ULK1, ATG12, RAB7A, WIPI1, RB1CC1, ATG2B, RAB1B, WDR45, WIPI2

GO:0034098

CC

VCP-NPL4-UFD1 AAA ATPase complex

A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).

UBXN7, VCP, CAV1, UFD1L, FAF2, FAF1

GO:0034271

CC

phosphatidylinositol 3-kinase complex, class III, type I

A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p.

PIK3R4

GO:0034272

CC

phosphatidylinositol 3-kinase complex, class III, type II

A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p.

PIK3R4

GO:0034274

CC

Atg12-Atg5-Atg16 complex

A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p.

ATG12

GO:0034359

CC

mature chylomicron

A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph.

APOB

GO:0034360

CC

chylomicron remnant

A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver.

APOB

GO:0034361

CC

very-low-density lipoprotein particle

A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver.

APOA1, APOE, APOA2, APOC1, APOC3, APOH, APOB, LPL, VLDLR, APOBR, APOA5, LSR, VIMP, APOO, PCYOX1

GO:0034362

CC

low-density lipoprotein particle

A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver.

LDLR, APOE, APOB, APOBR, PLA2G7, LSR, SORL1, VIMP, APOO

GO:0034363

CC

intermediate-density lipoprotein particle

A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL).

APOE, APOC3, APOB

GO:0034364

CC

high-density lipoprotein particle

A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.

ABCA1, APOA1, APOE, APOA2, APOC1, APOH, SAA1, SAA2, PON1, HDLBP, APOA5, APOO

GO:0034365

CC

discoidal high-density lipoprotein particle

A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase).

APOA1

GO:0034366

CC

spherical high-density lipoprotein particle

A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT).

APOA1, APOA2, APOC3, CLU, PON1

GO:0034388

CC

Pwp2p-containing subcomplex of 90S preribosome

A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p.

TBL3, WDR3, UTP18

GO:0034399

CC

nuclear periphery

The portion of the nuclear lumen proximal to the inner nuclear membrane.

IPO5, TNPO2, RANBP6, MAPT, TPR, ATF7, ATF4, NUP153, NUP107, KPNB1, NUP93, IPO4, AHCTF1, NUP205, EBNA1BP2

GO:0034448

CC

EGO complex

A vacuolar membrane-associated protein complex that is required for activation of microautophagy during exit from rapamycin-induced growth arrest. In budding yeast, S. cerevisiae, this complex includes Gtr1p, Gtr2p, Meh1p, and Slm4p.

RRAGC, RRAGD

GO:0034451

CC

centriolar satellite

A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.

OFD1, FLOT1, PCNT, KRT18, PCM1, CCDC14, SDCCAG8, HOOK3, PIBF1, FOPNL, SPAG5, CCDC113, EXOC7, SSX2IP

GO:0034455

CC

t-UTP complex

A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p.

UTP4, NOL11

GO:0034456

CC

UTP-C complex

A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p.

RRP7A

GO:0034464

CC

BBSome

A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B.

BBIP1, BBS7, BBS1, TTC8, BBS2

GO:0034515

CC

proteasome storage granule

A multisubunit proteasome complex that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state.

PSMD2

GO:0034518

CC

RNA cap binding complex

Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA.

NCBP1, NCBP3

GO:0034657

CC

GID complex

A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p.

MAEA, RMND5B, RMND5A

GO:0034663

CC

endoplasmic reticulum chaperone complex

A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1.

P4HB, HSPA5, HSP90B1, PPIB, PDIA6, DNAJC10, HYOU1

GO:0034665

CC

integrin alpha1-beta1 complex

An integrin complex that comprises one alpha1 subunit and one beta1 subunit.

ITGB1

GO:0034666

CC

integrin alpha2-beta1 complex

An integrin complex that comprises one alpha2 subunit and one beta1 subunit.

ITGB1, LYN, ITGA2

GO:0034667

CC

integrin alpha3-beta1 complex

An integrin complex that comprises one alpha3 subunit and one beta1 subunit.

ITGB1, ITGA3

GO:0034673

CC

inhibin-betaglycan-ActRII complex

A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B.

INHA, ACVR2A, TGFBR3

GO:0034676

CC

integrin alpha6-beta4 complex

An integrin complex that comprises one alpha6 subunit and one beta1 subunit.

ITGA6

GO:0034677

CC

integrin alpha7-beta1 complex

An integrin complex that comprises one alpha7 subunit and one beta1 subunit.

ITGB1

GO:0034678

CC

integrin alpha8-beta1 complex

An integrin complex that comprises one alpha8 subunit and one beta1 subunit.

ITGB1

GO:0034679

CC

integrin alpha9-beta1 complex

An integrin complex that comprises one alpha9 subunit and one beta1 subunit.

ITGA9

GO:0034680

CC

integrin alpha10-beta1 complex

An integrin complex that comprises one alpha10 subunit and one beta1 subunit.

ITGA10, ITGB1

GO:0034681

CC

integrin alpha11-beta1 complex

An integrin complex that comprises one alpha11 subunit and one beta1 subunit.

ITGB1, ITGA11

GO:0034683

CC

integrin alphav-beta3 complex

An integrin complex that comprises one alphav subunit and one beta3 subunit.

ITGB3, ITGAV

GO:0034684

CC

integrin alphav-beta5 complex

An integrin complex that comprises one alphav subunit and one beta5 subunit.

ITGAV, ITGB5

GO:0034686

CC

integrin alphav-beta8 complex

An integrin complex that comprises one alphav subunit and one beta8 subunit.

ITGAV, ITGB8

GO:0034687

CC

integrin alphaL-beta2 complex

An integrin complex that comprises one alphaL subunit and one beta2 subunit.

ITGB2

GO:0034702

CC

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

LRRC8A

GO:0034704

CC

calcium channel complex

An ion channel complex through which calcium ions pass.

PRKACA, CALM2, PDE4D, AKAP6, CAMK2D, PPP2R4, RYR3, MICU2, RYR2

GO:0034705

CC

potassium channel complex

An ion channel complex through which potassium ions pass.

KCNK1

GO:0034706

CC

sodium channel complex

An ion channel complex through which sodium ions pass.

SCNN1A, SCNN1G

GO:0034707

CC

chloride channel complex

An ion channel complex through which chloride ions pass.

FXYD1, CLIC1, BEST1, CLIC3, CFTR, GABRA5, CLCNKA, CLCNKB, ANO6, BEST3, CLIC6, TTYH1, ANO2, CLIC5

GO:0034709

CC

methylosome

A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.

SNRPB, SNRPF, SNRPD1, SNRPD2, SNRPD3, ERH, PRMT1

GO:0034715

CC

pICln-Sm protein complex

A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.

SNRPF, SNRPD1, SNRPD2, SNRPD3

GO:0034719

CC

SMN-Sm protein complex

A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm.

SNRPB, GEMIN4, SNRPF, SNRPD1, SNRPD2, SNRPD3, GEMIN5, GEMIN6, GEMIN8, DDX20

GO:0034750

CC

Scrib-APC-beta-catenin complex

A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation.

CTNNB1

GO:0034751

CC

aryl hydrocarbon receptor complex

A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR.

AIP

GO:0034752

CC

cytosolic aryl hydrocarbon receptor complex

An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP.

AHR

GO:0034753

CC

nuclear aryl hydrocarbon receptor complex

An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT).

AHR

GO:0034774

CC

secretory granule lumen

The volume enclosed by the membrane of a secretory granule.

POMC, GCG, INS, APOA1, TF, PCSK1, GHRL

GO:0034991

CC

nuclear meiotic cohesin complex

A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the meiotic cohesin complex.

RAD21, SMC3

GO:0034993

CC

LINC complex

A protein complex that spans the nuclear outer and inner membranes, thereby linking the major cytoplasmic cytoskeleton elements to the nuclear lumen; the complex is conserved in eukaryotes and contains proteins with SUN and KASH domains.

SYNE2, SUN2

GO:0035032

CC

phosphatidylinositol 3-kinase complex, class III

A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI).

PIK3C3, NRBF2, PIK3R4

GO:0035061

CC

interchromatin granule

A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs).

SRSF2, TARDBP, SMC5, SMC6

GO:0035068

CC

micro-ribonucleoprotein complex

A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA.

TNRC6A, AGO4, AGO2

GO:0035097

CC

histone methyltransferase complex

A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.

KDM6A, CBX5, RBBP5, KMT2C, PAGR1, ZNF335, ASH2L, HDAC9, KMT2B

GO:0035098

CC

ESC/E(Z) complex

A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.

H2AFY, TRIM37, RBBP4, SUZ12, EZH2, PHF19, HDAC2, EZH1, H2AFY2, MTF2

GO:0035101

CC

FACT complex

An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer.

TONSL

GO:0035102

CC

PRC1 complex

A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.

CBX7, RING1, PHC3

GO:0035145

CC

exon-exon junction complex

A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.

SAP18, SRSF1, RNPS1, ALYREF, UHMK1, POLDIP3, UPF3A, PNN, UPF2, THRAP3, R3HCC1, RBM8A

GO:0035189

CC

Rb-E2F complex

A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression.

RB1, E2F1

GO:0035253

CC

ciliary rootlet

A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm.

KIF5C, APP, PSEN1, RAB28, CROCC, KLC3

GO:0035267

CC

NuA4 histone acetyltransferase complex

A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).

YEATS4, ACTL6A, ACTB, MORF4L2, EPC1, MEAF6, ING3, MORF4L1, RUVBL2, RUVBL1, TRRAP

GO:0035327

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transcriptionally active chromatin

The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.

PSIP1, ESR1, HIST1H1C, ICE2, EXOSC4, EXOSC3, AFF4

GO:0035339

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SPOTS complex

A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis.

ORMDL2

GO:0035354

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Toll-like receptor 1-Toll-like receptor 2 protein complex

A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2).

TLR2, TLR1

GO:0035363

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histone locus body

A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body.

ICE2

GO:0035370

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UBC13-UEV1A complex

A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A).

UBE2V1

GO:0035371

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microtubule plus-end

The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability.

CLIP1, DST, CKAP5, MAPRE2, MAPRE1, KIF18B, SPAG5, KIF2C, SLAIN2, CLIP2, MAPRE3, KNSTRN, MYO5A

GO:0035517

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PR-DUB complex

A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively.

BAP1

GO:0035577

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azurophil granule membrane

The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.

VAMP7

GO:0035686

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sperm fibrous sheath

A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat.

GSTM3, SPA17