|
GO:0030670
|
CC
|
phagocytic vesicle membrane
|
The lipid bilayer surrounding a phagocytic vesicle.
|
ATP6V0E1,
TLR2,
ATG12,
HLA-B,
CYBB,
ANXA3,
LAMP2,
HLA-E,
RAC2,
HLA-G,
RAB5A,
HLA-A,
HLA-F,
CORO1A,
SLC11A1,
RAB7A,
RAB9A,
VAMP7,
ATP6V0D1,
B2M,
OCRL,
TCIRG1,
RAB31,
RAB32,
TLR1,
RAB11B,
RAB11FIP1,
PIK3C3,
RAB8B,
ATP6V0A1,
PIK3R4,
RAB34,
DMBT1,
RAB22A,
RAB23
|
|
GO:0030672
|
CC
|
synaptic vesicle membrane
|
The lipid bilayer surrounding a synaptic vesicle.
|
SCAMP1,
SYNGR2,
SYNGR3,
SNAPIN,
DRD2,
SYN1,
SYT1,
VAMP2,
ICA1,
SLC18A2,
RAB11B,
SV2A,
SV2B,
DMXL2,
SYN2,
SYT11
|
|
GO:0030673
|
CC
|
axolemma
|
The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.
|
MYO1D,
ADORA1,
CHRNA7,
SLC1A2,
SPTBN1,
NRG1,
KCNJ11,
ROBO2,
MAPK8IP3,
EPB41L3
|
|
GO:0030677
|
CC
|
ribonuclease P complex
|
A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs.
|
POP4
|
|
GO:0030686
|
CC
|
90S preribosome
|
A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
|
UTP20,
RSL1D1,
RPSA,
RPS7
|
|
GO:0030687
|
CC
|
preribosome, large subunit precursor
|
A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.
|
NSA2,
RPLP1,
RPLP2,
RPLP0,
EIF6,
BOP1,
RRP1B,
RRS1,
WDR74,
EBNA1BP2,
WDR12,
MDN1,
MRTO4,
NIP7,
WDR37,
LAS1L
|
|
GO:0030688
|
CC
|
preribosome, small subunit precursor
|
A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.
|
UTP20,
RRP1B,
TSR1,
NOB1
|
|
GO:0030690
|
CC
|
Noc1p-Noc2p complex
|
A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis.
|
NOC2L
|
|
GO:0030691
|
CC
|
Noc2p-Noc3p complex
|
A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.
|
NOC2L
|
|
GO:0030849
|
CC
|
autosome
|
Any chromosome other than a sex chromosome.
|
SIN3B
|
|
GO:0030863
|
CC
|
cortical cytoskeleton
|
The portion of the cytoskeleton that lies just beneath the plasma membrane.
|
ACTN4,
GYPC,
EZR,
SELE,
FLNA,
TMOD1,
ACTB,
TPM4,
DLG4,
MPP1,
CTTN,
NSMF
|
|
GO:0030864
|
CC
|
cortical actin cytoskeleton
|
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
|
FLOT1,
SLC2A1,
CDH2,
CORO1A,
NF2,
RDX,
ACTN2,
GYS2,
DSTN,
EEF1A1,
AKAP13,
SHROOM2,
PLEKHH2,
MYRIP,
PDLIM2,
DLC1,
MYADM,
MLPH,
TRPV4
|
|
GO:0030867
|
CC
|
rough endoplasmic reticulum membrane
|
The lipid bilayer surrounding the rough endoplasmic reticulum.
|
PLOD2,
UBA1,
PLOD1,
PI4KB
|
|
GO:0030868
|
CC
|
smooth endoplasmic reticulum membrane
|
The lipid bilayer surrounding the smooth endoplasmic reticulum.
|
HSD3B1,
HSD3B2,
SEC23A,
SVIP,
TTYH1
|
|
GO:0030870
|
CC
|
Mre11 complex
|
Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
|
NBN,
SP100,
MRE11A,
RAD50
|
|
GO:0030877
|
CC
|
beta-catenin destruction complex
|
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
|
AXIN1,
APC,
CTNNB1,
CSNK1A1,
GSK3B,
SIAH1,
CACYBP,
DACT1
|
|
GO:0030891
|
CC
|
VCB complex
|
A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.
|
RBX1,
CUL2,
TCEB1,
TCEB2
|
|
GO:0030892
|
CC
|
mitotic cohesin complex
|
A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex.
|
SGOL2
|
|
GO:0030893
|
CC
|
meiotic cohesin complex
|
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
|
SMC1A,
SMC3
|
|
GO:0030894
|
CC
|
replisome
|
A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
|
PCNA
|
|
GO:0030895
|
CC
|
apolipoprotein B mRNA editing enzyme complex
|
Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP).
|
APOBEC3G
|
|
GO:0030896
|
CC
|
checkpoint clamp complex
|
Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage.
|
RAD1,
RAD9B,
RAD9A
|
|
GO:0030897
|
CC
|
HOPS complex
|
A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion.
|
HOOK3,
HOOK2,
AKTIP
|
|
GO:0030904
|
CC
|
retromer complex
|
A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35.
|
SNX3,
VPS26A,
RAB7A,
SNX1,
DCTN1,
DENND5A,
TBC1D5,
VPS35,
ANKFY1,
VPS29,
SNX6,
SNX5
|
|
GO:0030905
|
CC
|
retromer, tubulation complex
|
The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodelling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6.
|
SNX1,
SNX6,
SNX5
|
|
GO:0030906
|
CC
|
retromer, cargo-selective complex
|
The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals.
|
VPS26A,
VPS35,
VPS29
|
|
GO:0030914
|
CC
|
STAGA complex
|
A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs.
|
SUPT3H,
TADA3,
SUPT7L,
TAF10,
TAF12,
TADA2B,
TADA1,
TRRAP
|
|
GO:0030915
|
CC
|
Smc5-Smc6 complex
|
A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans.
|
SMC5,
EID3,
SMC6,
NSMCE4A
|
|
GO:0030956
|
CC
|
glutamyl-tRNA(Gln) amidotransferase complex
|
A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms.
|
GATC,
GATB,
QRSL1
|
|
GO:0030981
|
CC
|
cortical microtubule cytoskeleton
|
The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane.
|
MAPRE1
|
|
GO:0030990
|
CC
|
intraciliary transport particle
|
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
|
DYNC2LI1,
KIFAP3
|
|
GO:0030991
|
CC
|
intraciliary transport particle A
|
The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa.
|
TULP3,
IFT43,
IFT122,
WDR35
|
|
GO:0030992
|
CC
|
intraciliary transport particle B
|
The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa.
|
IFT81,
CLUAP1,
IFT74,
IFT27,
IFT46,
HSPB11
|
|
GO:0031011
|
CC
|
Ino80 complex
|
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.
|
ACTL6A,
YY1,
NFRKB,
INO80C,
INO80E,
INO80B,
RUVBL2,
RUVBL1,
UCHL5
|
|
GO:0031012
|
CC
|
extracellular matrix
|
A structure lying external to one or more cells, which provides structural support for cells or tissues.
|
MATN2,
CYR61,
PLSCR1,
TGFB1I1,
COCH,
EDIL3,
CILP,
FLNB,
CSTA,
PDGFB,
TGFB1,
COL1A1,
COL3A1,
LMNA,
APOE,
APCS,
APOH,
FN1,
AHSG,
SLPI,
VTN,
KRT1,
VWF,
GAPDH,
HSPB1,
SERPINE1,
SLC25A5,
CLEC3B,
COL5A2,
S100A9,
LPL,
SERPINE2,
P4HB,
CTSD,
ANXA2,
TUBB,
DCN,
HSP90AA1,
LAMB1,
THBS1,
COL1A2,
MMP2,
SOD3,
MGP,
COL4A2,
VIM,
RPS17,
LGALS1,
WNT2,
HSPD1,
CLU,
HAPLN1,
HSPA5,
LAMC1,
COL6A1,
COL6A2,
COL6A3,
VCAN,
EEF2,
NID1,
PKM,
HSP90B1,
JUP,
DSP,
TIMP2,
DDX5,
LGALS3,
RPL35A,
ARF4,
OGN,
COL5A1,
FLNA,
ZP3,
FGFR2,
BGN,
TGM2,
TNXB,
FBLN1,
SFPQ,
CFL1,
LAMA2,
TNC,
COL8A2,
CANX,
CFP,
PCSK6,
RPL12,
RPL22,
THBS4,
FBN1,
FBN2,
MYH9,
TIMP3,
SERPINF1,
COL15A1,
COL18A1,
CCT6A,
RPS5,
RPS10,
ATP5O,
TFPI2,
NES,
TGM4,
COMP,
MMP14,
MMP15,
LUM,
HNRNPM,
ADAMTS12,
ADAMTS20,
MYL6,
EIF4A1,
RPS20,
RPS3A,
RPL27,
TGFB2,
RPS7,
RPS15A,
RPS16,
RPS14,
RPS18,
RPS13,
RPS11,
HIST1H4A,
RPS25,
RPL30,
RPL11,
RAC1,
ACTG1,
TUBB4B,
CCT2,
PRKDC,
FBLN2,
HSPG2,
NDP,
HNRNPU,
COL14A1,
FMOD,
PRDX1,
LOXL1,
MFGE8,
EFEMP1,
MMRN1,
ILK,
NID2,
DYNC1H1,
GANAB,
LTBP1,
POSTN,
PCOLCE,
TOMM20,
TGFBI,
IGFBP7,
LAMA4,
SBSN,
THSD4,
FBN3,
FRAS1,
AEBP1,
SBSPON,
SFRP1,
NDNF,
HTRA1,
COL21A1,
COL12A1,
RARRES2,
SOST,
EMILIN2,
TINAGL1,
ADAMTS10,
SPON1,
CD93,
LTBP3,
LMCD1,
ADAMTS9,
ADAMTS8,
LOXL2
|
|
GO:0031021
|
CC
|
interphase microtubule organizing center
|
A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus.
|
MZT1
|
|
GO:0031045
|
CC
|
dense core granule
|
Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.
|
SCG2,
SYT1,
NCS1,
MYRIP
|
|
GO:0031074
|
CC
|
nucleocytoplasmic shuttling complex
|
Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores.
|
NUP62
|
|
GO:0031080
|
CC
|
nuclear pore outer ring
|
A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).
|
SEC13,
NUP107,
NUP160,
NUP43,
NUP37,
AHCTF1,
SEH1L,
NUP85
|
|
GO:0031083
|
CC
|
BLOC-1 complex
|
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins.
|
SNAPIN,
SNAP25,
BLOC1S1,
BLOC1S3,
BLOC1S6
|
|
GO:0031084
|
CC
|
BLOC-2 complex
|
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru.
|
HPS3
|
|
GO:0031085
|
CC
|
BLOC-3 complex
|
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins.
|
HPS1,
HPS4
|
|
GO:0031088
|
CC
|
platelet dense granule membrane
|
The lipid bilayer surrounding the platelet dense granule.
|
ABCC4,
LAMP2,
ITPR1
|
|
GO:0031089
|
CC
|
platelet dense granule lumen
|
The volume enclosed by the membrane of the platelet dense granule.
|
APOH,
CLEC3B,
TIMP3,
SEPP1,
SPP2,
FAM3C,
RARRES2
|
|
GO:0031090
|
CC
|
organelle membrane
|
A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
|
MGST3,
FLRT2,
CYP26A1,
CYP1A1,
UGT2B4,
EPHX1,
CYP3A4,
CYP21A2,
CYP2D6,
TFPI,
CYP2A6,
CYP2C9,
SRD5A1,
CYP2B6,
CYP3A5,
AADAC,
PTGS1,
CYP3A7,
SRD5A2,
FMO4,
PTGS2,
SQLE,
SPCS2,
CYP1B1,
CYP51A1,
CYP2R1,
FA2H,
CYP2U1,
RDH10,
FMO2,
MGST2,
DHRS9,
SEC11C,
SLC39A8,
MAP1LC3B,
MAP1LC3A,
CYP3A43,
CYP26B1,
CYP8B1,
POMP
|
|
GO:0031091
|
CC
|
platelet alpha granule
|
A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).
|
FGA,
FGB,
FGG,
VWF,
SERPINA5,
SERPINE2,
THBS1,
SPARC,
VAMP7,
STXBP1
|
|
GO:0031092
|
CC
|
platelet alpha granule membrane
|
The lipid bilayer surrounding the platelet alpha granule.
|
PHACTR2,
ITGB3,
SPARC,
PECAM1,
CD36,
CD9,
SNCA,
APLP2
|
|
GO:0031093
|
CC
|
platelet alpha granule lumen
|
The volume enclosed by the membrane of the platelet alpha granule.
|
ISLR,
ACTN4,
F8,
F13A1,
PLG,
SERPINA1,
SERPINA3,
A2M,
TIMP1,
KNG1,
PDGFB,
TGFB1,
IGF2,
FGA,
FGB,
FGG,
FN1,
ORM1,
AHSG,
ALB,
PPBP,
PF4,
ALDOA,
PDGFA,
A1BG,
VWF,
IGF1,
APP,
SERPINE1,
SERPING1,
THBS1,
SPARC,
SRGN,
CLU,
F5,
ACTN1,
HGF,
VEGFA,
ORM2,
ACTN2,
VEGFB,
VEGFC,
TGFB2,
TMSB4X,
MMRN1,
GAS6
|
|
GO:0031094
|
CC
|
platelet dense tubular network
|
A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin.
|
SERPINA5,
F2R,
ITPR1
|
|
GO:0031095
|
CC
|
platelet dense tubular network membrane
|
The lipid bilayer surrounding the platelet dense tubular network.
|
ATP2A2,
ITPR2,
ITPR3,
ITPR1
|
|
GO:0031105
|
CC
|
septin complex
|
A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric.
|
SEPT6,
SEPT2,
SEPT7
|
|
GO:0031143
|
CC
|
pseudopodium
|
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.
|
ACTN4,
LDB3,
RAF1,
CNP,
ACTN1,
MAPK3,
MAPK1,
ACTN2,
VAMP7,
F2RL1,
MYOZ1
|
|
GO:0031201
|
CC
|
SNARE complex
|
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
|
SNAP23,
GOSR2,
STX7,
STX6,
VAMP4,
SEC22B,
STX11,
SNX4,
SNAP29,
SYT1,
STX2,
VAMP7,
SNAP25,
VAMP2,
STX4,
STX3,
STXBP2,
VAMP3,
STXBP5,
SEC22A,
NAPB,
BET1L,
VTI1B,
BLOC1S6,
STXBP5L
|
|
GO:0031205
|
CC
|
endoplasmic reticulum Sec complex
|
An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex.
|
CFTR,
DNAJC3
|
|
GO:0031209
|
CC
|
SCAR complex
|
A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.
|
CYFIP1,
ABI1,
ABI2,
WASF2
|
|
GO:0031213
|
CC
|
RSF complex
|
An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters).
|
SMARCA5,
RSF1
|
|
GO:0031224
|
CC
|
intrinsic component of membrane
|
The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane.
|
BNIP3L,
KCNJ12,
LOH12CR1
|
|
GO:0031225
|
CC
|
anchored component of membrane
|
The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
|
TNFRSF10C,
FCGR3B,
SEMA7A,
TECTA,
GPC4,
VNN1,
RECK,
PRNP,
ALPL,
LPL,
CD55,
CD48,
TFPI,
TDGF1,
NCAM1,
CPM,
CD58,
NT5E,
GPC1,
SPAM1,
EFNA4,
CDH13,
PLAUR,
BST2,
CNTN1,
LSAMP,
CEACAM7,
LY6E,
CNTN4,
GPC2,
LYPD1,
CD177,
SVIP,
ITLN1,
BCAN,
MMP25,
NRN1,
VNN3,
CNTN3,
PRND,
GPC6
|
|
GO:0031226
|
CC
|
intrinsic component of plasma membrane
|
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
|
TLR4,
TLR2,
TNFRSF21,
PDGFRB,
PDGFRA,
S1PR1,
TGM2,
CD6,
ALCAM,
ADIPOR2,
TRPV1,
ADIPOR1
|
|
GO:0031227
|
CC
|
intrinsic component of endoplasmic reticulum membrane
|
The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
|
ESYT2,
CYP2E1,
PGAP3
|
|
GO:0031228
|
CC
|
intrinsic component of Golgi membrane
|
The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
|
CHST4,
CHST5,
ZDHHC9,
CHST2
|
|
GO:0031232
|
CC
|
extrinsic component of external side of plasma membrane
|
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.
|
PLG,
TF,
ANXA1,
SERPINE2,
PCSK9
|
|
GO:0031233
|
CC
|
intrinsic component of external side of plasma membrane
|
The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor.
|
ADAM9
|
|
GO:0031234
|
CC
|
extrinsic component of cytoplasmic side of plasma membrane
|
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
|
ESYT2,
CYTH3,
JAK2,
KRAS,
FYN,
S100A6,
LYN,
FGR,
ALOX15,
ATP2A2,
JAK1,
CSK,
ABL2,
SYK,
IQGAP1,
CAV2,
JAK3,
RHOA,
DLG4,
CDK16,
PTK2,
TNK2,
TIAM1,
STYK1,
SNX18,
RACGAP1,
CYLD,
ERRFI1,
FARP1,
DTNA,
SNX9,
SNX5
|
|
GO:0031235
|
CC
|
intrinsic component of the cytoplasmic side of the plasma membrane
|
The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only.
|
RASA4,
RASA1,
RASA3,
RASA2,
SYNGAP1
|
|
GO:0031251
|
CC
|
PAN complex
|
A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.
|
PAN3
|
|
GO:0031252
|
CC
|
cell leading edge
|
The area of a motile cell closest to the direction of movement.
|
ARPC2,
LDB2,
VIM,
ITGB4,
TUBG1,
MYH9,
PRKCI,
CXCR4,
LMO4,
ARF1,
DST,
DCTN1,
AAK1,
CDC42BPA,
LRRC16A,
BSPRY,
PHLDB2,
JMY,
DOCK8,
GBF1,
CORO1B,
NDEL1,
HDAC6,
SSX2IP,
CDC42BPB
|
|
GO:0031253
|
CC
|
cell projection membrane
|
The portion of the plasma membrane surrounding a cell surface projection.
|
DLG1,
MAPRE1,
FSCN1,
BVES,
NDRG4
|
|
GO:0031256
|
CC
|
leading edge membrane
|
The portion of the plasma membrane surrounding the leading edge of a motile cell.
|
MYO1G,
CDC42,
PTPRK
|
|
GO:0031258
|
CC
|
lamellipodium membrane
|
The portion of the plasma membrane surrounding a lamellipodium.
|
ITGB3,
ITGAV,
CFL1,
DPP4,
SLC39A6,
CSPG4,
PDPN,
SYNE2,
PIEZO1,
PLEK2
|
|
GO:0031261
|
CC
|
DNA replication preinitiation complex
|
A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.
|
ORC3
|
|
GO:0031262
|
CC
|
Ndc80 complex
|
A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore.
|
NDC80,
SPC24,
NUF2,
SPC25
|
|
GO:0031264
|
CC
|
death-inducing signaling complex
|
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.
|
CFLAR,
FAS,
FADD,
RIPK1,
CASP8,
TRADD
|
|
GO:0031265
|
CC
|
CD95 death-inducing signaling complex
|
A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor.
|
CFLAR,
FAS,
FADD,
CASP8,
FAF1
|
|
GO:0031298
|
CC
|
replication fork protection complex
|
A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.
|
TOP1,
MCM10,
GINS4,
TIPIN,
GINS2
|
|
GO:0031301
|
CC
|
integral component of organelle membrane
|
The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
TRABD2A,
RNF152,
ITM2B
|
|
GO:0031302
|
CC
|
intrinsic component of endosome membrane
|
The component of the endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
|
ECE1
|
|
GO:0031305
|
CC
|
integral component of mitochondrial inner membrane
|
The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
TIMM23,
TIMM17B,
TMEM11,
ETFDH,
UQCC3,
MCUR1,
TIMM17A,
APOO,
COA3
|
|
GO:0031306
|
CC
|
intrinsic component of mitochondrial outer membrane
|
The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
|
MFN2
|
|
GO:0031307
|
CC
|
integral component of mitochondrial outer membrane
|
The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
TOMM40,
CPT1A,
SYNJ2BP,
DMPK,
BNIP3,
TOMM20,
MGARP,
FUNDC2,
PINK1,
ABCB6,
TOMM22,
TOMM7,
ARMCX3
|
|
GO:0031313
|
CC
|
extrinsic component of endosome membrane
|
The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
ANXA1,
SNX16,
SNX5
|
|
GO:0031314
|
CC
|
extrinsic component of mitochondrial inner membrane
|
The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
OPA1,
NDUFAF5,
DUSP21,
PAM16
|
|
GO:0031315
|
CC
|
extrinsic component of mitochondrial outer membrane
|
The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
SARM1
|
|
GO:0031362
|
CC
|
anchored component of external side of plasma membrane
|
The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
|
CD14,
FOLR1,
CA4,
CD24,
EFNA5,
HYAL2,
GGT7
|
|
GO:0031371
|
CC
|
ubiquitin conjugating enzyme complex
|
Any complex that possesses ubiquitin conjugating enzyme activity.
|
UBE2V1,
STUB1
|
|
GO:0031372
|
CC
|
UBC13-MMS2 complex
|
A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p.
|
UBE2V2
|
|
GO:0031380
|
CC
|
nuclear RNA-directed RNA polymerase complex
|
A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain.
|
PAPD4
|
|
GO:0031390
|
CC
|
Ctf18 RFC-like complex
|
A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p.
|
RFC4,
RFC2,
RFC5,
RFC3,
CHTF18,
DSCC1
|
|
GO:0031410
|
CC
|
cytoplasmic vesicle
|
A vesicle found in the cytoplasm of a cell.
|
WASH1,
NRP1,
AXIN1,
PDE6D,
KIF1B,
PDCD6,
LRP6,
RP2,
FLOT1,
MYO1D,
SNAP29,
TGFA,
APOA1,
ERBB2,
NTRK1,
TH,
ITGA5,
IGFBP2,
ATP6V1C1,
SERPINB3,
SLC11A2,
PSEN1,
MMP14,
CAV2,
CLCN3,
CLCN7,
EMP2,
PRSS12,
GABARAPL2,
CXCR4,
RAB11A,
VAMP2,
DSC2,
CAV1,
HYAL2,
CALCOCO2,
SQSTM1,
NBR1,
EEA1,
OCLN,
HFE,
CCDC88A,
RAB12,
TECPR1,
MIB1,
TP53INP2,
AMOTL1,
KIAA0319L,
ARRDC1,
RIN3,
BICD2,
SH3TC2,
SLC9A6,
USP6NL,
TP53INP1,
MARVELD3,
BICD1,
C9orf72,
ARAP1,
MAP1LC3B,
MAP1LC3A,
TRPV4,
UBQLN4,
FLRT1,
SPAST,
ADAMTS1,
TFR2,
PIKFYVE,
SH3GLB1,
F11R,
ARFGEF2
|
|
GO:0031415
|
CC
|
NatA complex
|
A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins.
|
NAA15,
NAA50
|
|
GO:0031416
|
CC
|
NatB complex
|
A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p.
|
NAA25
|
|
GO:0031417
|
CC
|
NatC complex
|
A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p.
|
NAA30
|
|
GO:0031428
|
CC
|
box C/D snoRNP complex
|
A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type that can carry out ribose-2'-O-methylation of target RNAs.
|
NOP56,
SNU13
|
|
GO:0031429
|
CC
|
box H/ACA snoRNP complex
|
A box H/ACA RNP complex that is located in the nucleolus.
|
DKC1,
NOP10,
GAR1
|
|
GO:0031430
|
CC
|
M band
|
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
|
OBSL1,
CRYAB,
ALDOA,
ENO1,
SPTBN1,
ANK2,
NBR1,
PPP2R5A,
CMYA5
|
|
GO:0031436
|
CC
|
BRCA1-BARD1 complex
|
A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage.
|
BRCA1,
BARD1
|
|
GO:0031461
|
CC
|
cullin-RING ubiquitin ligase complex
|
Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
|
RBX1,
CAND1,
GLMN
|
|
GO:0031462
|
CC
|
Cul2-RING ubiquitin ligase complex
|
A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
|
RBX1,
CUL2,
TCEB2,
COMMD1,
GLMN
|
|
GO:0031463
|
CC
|
Cul3-RING ubiquitin ligase complex
|
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
|
ENC1,
BACH1,
RBX1,
CUL3,
KLHL12,
SPOPL,
KLHL24,
KLHL7,
KBTBD2,
KLHDC8A,
KLHL36,
KLHL23,
KCTD13,
GLMN,
KLHDC7B,
KLHL15,
KLHL32,
KLHL5,
BACH2,
KLHL4,
KCTD10,
KLHL28,
KLHL8,
KLHL9,
KLHL42,
KLHL13,
KLHL3
|
|
GO:0031464
|
CC
|
Cul4A-RING E3 ubiquitin ligase complex
|
A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
|
CDKN1B,
RBX1,
CUL4A,
GLMN,
DTL
|