GO:0060076

CC

excitatory synapse

A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.

SRPX2, SYT1, FGFR2, ITGA3, DLG4, NLGN4X, SYT11

GO:0060077

CC

inhibitory synapse

A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell.

SYT11, IGSF9B

GO:0060091

CC

kinocilium

A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia.

DCDC2

GO:0060170

CC

ciliary membrane

The portion of the plasma membrane surrounding a cilium.

CASK, GPI, DRD2, SCNN1A, EPS15, EVC, PKD1, PKD2, PTCH1, SEPT2, TCTN3, BBS7, BBS1, TTC8, TCTN2, HHIP, BBS2

GO:0060171

CC

stereocilium membrane

The portion of the plasma membrane surrounding a stereocilium.

MYO1C, FAM65B

GO:0060201

CC

clathrin-sculpted acetylcholine transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle.

SYT1

GO:0060203

CC

clathrin-sculpted glutamate transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle.

SYT1, VAMP2

GO:0060205

CC

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

ADA

GO:0060987

CC

lipid tube

A macromolecular complex that contains a tube of lipid surrounded by a protein coat.

BIN1

GO:0061202

CC

clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle.

SYT1, VAMP2

GO:0061474

CC

phagolysosome membrane

The lipid bilayer surrounding a phagolysosome.

LAMP1

GO:0061574

CC

ASAP complex

A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.

SAP18, RNPS1

GO:0061617

CC

MICOS complex

Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60.

APOOL, APOO

GO:0061618

CC

sublamina densa

The part of the basement membrane that lies beneath the lamina densa, containing anchoring fibrils, anchoring plaques, collagen fibers, and elastic fibers.

FRAS1

GO:0061689

CC

tricellular tight junction

An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet.

LSR

GO:0061700

CC

GATOR2 complex

A multiprotein subcomplex of GATOR that regulates mTOR signaling by interacting with the Rag GTPases. In humans this complex consists of Mios, WDR24, WDR59, Seh1L, Sec13.

SEC13, SESN2, SESN3, SEH1L, SESN1

GO:0065010

CC

extracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.

ALPL

GO:0070022

CC

transforming growth factor beta receptor homodimeric complex

A homodimeric receptor complex that consists of two TGF-beta receptor monomers.

TGFBR1, TGFBR2, DAB2

GO:0070032

CC

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).

SNAP25, VAMP2

GO:0070033

CC

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).

VAMP2, CPLX2

GO:0070044

CC

synaptobrevin 2-SNAP-25-syntaxin-1a complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).

VAMP2

GO:0070062

CC

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

VPS37C, MYO1G, IGLL5, ACOT7, MYO1C, SNAP23, MASP2, RAB27B, LGALS8, PSMD11, PSMD12, AGRP, CLIC1, WWP2, WASL, PIK3C2A, PLOD2, NDUFA4, CHL1, SDCBP, DDX3X, RNASET2, KPNA4, MAN2B1, FBP2, PDXK, PLPP1, PLPP3, ISLR, ENPP3, CHD2, TOR1A, ADAM10, ITGB1BP1, PDCD5, TPP1, MGST3, IRF6, TAX1BP3, RAB29, SLC27A2, HNRNPDL, PLXNB2, PFAS, NPC1, SCAMP2, ARPC2, ARPC3, PLSCR1, CTDSPL, KMO, PMM2, STX7, CAPN5, CLDN3, FLRT2, PHGDH, PSMD3, B4GALT5, EEF1E1, COCH, MGAM, AKR7A2, B4GAT1, CHMP2A, TSPAN6, ASNA1, PI15, ACTN4, ITM2A, SYNGR2, EDIL3, AHCYL1, CD5L, GNG7, SPAG9, TBC1D4, PPL, LY75, ACSL4, SNX3, GMDS, SELENOF, PDE8A, UGDH, TPST2, CTNND1, EDF1, DNAJA2, FCGR3B, WDR1, CILP, PDCD6, ATP6V1G1, VPS4B, MPDU1, ENTPD6, H2AFY, FLNB, VPS26A, TECTA, GPC4, CLN5, BANF1, LYPLA1, CREG1, RP2, IDH1, TNFSF13, ALDH1L1, RASSF9, ARL6IP5, ATP5H, FLOT1, ATP5L, NEBL, SEC14L2, WISP2, SLC22A5, DDAH1, SLIT2, MYO1D, TMEM63A, PROSC, ERLIN2, RHOBTB3, CLSTN1, PRSS23, NDUFB4, PGLS, SMC2, LYPLA2, VNN1, SFT2D2, STAMBP, WIZ, STAU1, CLIC3, ANGPTL1, DDAH2, EFEMP2, NUDT3, NDUFB10, TOMM40, PEX11B, CYB5A, LDHA, ALDH1A1, CYB5R3, GSR, PNP, GOT2, PGK1, AK1, F2, C1R, HP, PLG, PLAU, PLAT, CFB, CA2, ASS1, SPINK1, SERPINC1, SERPINA1, SERPINA3, AGT, A2M, C3, TIMP1, CST3, CSTA, KNG1, NRAS, FSHB, LHB, IGF2, IL1B, HLA-DRA, CRYAB, APOA1, APOE, APOA2, APOC1, APOC3, FGA, FGB, FGG, PMP2, GYPA, CRP, APCS, C1QA, APOH, LRG1, FN1, RBP4, AMBP, ORM1, AHSG, TTR, ALB, GC, TFRC, TF, FTL, FTH1, ANG, SLPI, VTN, FUCA1, ALDOA, CSTB, ANXA1, APOB, PRNP, SOD2, A1BG, CD74, KRT1, VWF, SHBG, TUBB4A, GAPDH, HSPB1, GNAI2, ATP1B1, APP, APOD, ALDH2, ITGB3, ITGB2, S100A8, SERPINE1, SLC25A5, SERPINA5, SERPING1, CFI, MPO, ALPL, EIF2S1, ICAM1, RPLP1, RPLP2, RPLP0, FABP3, CLEC3B, ITGB1, PRKCB, KRT18, KRT8, INSR, PTMA, CDK1, S100A9, S100A6, EIF4E, ENO1, GPI, TPM3, ITGAV, LPL, HEXA, DBI, LDHB, GPX1, P4HB, KLK3, ACYP1, CTSD, ANXA2, C8G, TUBB, PRSS1, PSAP, CTSL, PFN1, BPGM, APRT, CTSB, HSP90AA1, HNRNPC, LAMB1, LYN, FH, THBS1, RNASE1, COL1A2, ANXA6, CD55, SLC3A2, HSP90AB1, GSTA1, SOD3, MME, MGP, CD14, COL4A2, PTPRC, MFI2, CFH, VIM, RPS17, KRT19, KRT7, GNAI3, ANXA5, KRT16, RPSA, ENO2, GSTP1, CD48, LGALS1, QDPR, FBP1, ANXA4, CNP, PDGFRB, HNRNPA1, CTSH, FGR, C1S, UCHL1, FURIN, ALDOC, C4A, C4B, H2AFZ, HIST1H2AG, CHTF8, GSTT2, UBC, SAA1, SAA2, RAP2A, RNASE2, GAA, RRAS, HIST1H1E, SPP1, PTPRF, TXN, COX5B, C7, HSPD1, CLU, HSPA5, LAMC1, SLC2A1, SLC2A3, PDHB, ITGAM, PYGB, PYGM, RALA, RALB, BCR, LAMP1, G6PD, MTHFD1, IGF2R, PRPS2, PCNA, KRT3, COL6A1, COL6A2, COL6A3, CKB, FCGR2A, ANXA3, CKMT1A, BMP3, ACTN1, ACE, LAMP2, RNH1, CFTR, NCAM1, EEF2, KRT13, C6, TPT1, ALAD, PRG2, HLA-E, LCP1, PRKAR2A, ENO3, MIF, CPM, NID1, PLA2G2A, PKM, HSP90B1, MYL6B, SLC2A4, SNRPB, MMP9, HNRNPL, DARS, JUP, FABP4, AKR1B1, PVR, RAC2, ARSA, B4GALT1, ACPP, EZR, FOLR1, UCHL3, HPGD, CD46, NME1, NQO1, GNS, ARSB, RPS2, ST6GAL1, DSP, MUC1, TIMP2, CD44, NQO2, H2AFX, ITGB4, CBR1, PECAM1, EPCAM, GNB3, CPE, PLCG2, FAH, STMN1, HSPA6, RHOQ, PRKCA, GJA1, NPR3, PRKACA, DES, DDX5, PFKL, GM2A, CR1, LGALS3, IGFBP3, TCP1, IGFBP2, RPL35A, ITGB5, ARF4, RPL7, IL1RN, PGAM1, SDC1, PAM, CDH2, TSPAN8, MYL12A, CD58, VCAM1, CD53, ORM2, AMY2B, ATP2B1, CD33, KLK2, RAB3B, RAB5A, PSMB1, HIST1H2AD, COX5A, OGN, EFNA1, COL5A1, GSTM3, ATP6V1B2, ATP6V1C1, CSRP1, FLNA, TNFAIP3, NT5E, BGN, SDHB, CD9, COMT, TGM2, PCMT1, GART, TNXB, PAICS, SCP2, UBA1, GPX3, NME2, HNRNPA2B1, UQCRC2, SLC2A5, CA4, FBLN1, PTGS1, PPIB, PTPRD, PTPRG, AHCY, CFL1, RRM1, LAMA2, IGFBP6, AZGP1, MPST, FAS, DNAJB1, PSMA1, PSMA2, PSMA3, PSMA4, S100P, COL5A3, ITGA3, ITGB8, S100A4, PTBP1, TARS, CD27, FKBP2, MST1, STOM, AK4, PON1, MAOB, MAPK3, DPP4, CAD, CALR, CANX, PSMB8, PSMB9, PSMB4, PSMB5, GSTM2, MAPK1, GRN, LAP3, TNFRSF8, IMPA1, TKT, SERPINB3, MARCKS, GNA11, PBLD, ERP29, PRDX6, BLVRB, DDT, RPL12, ECHS1, CMPK1, PEBP1, PDIA3, PPP2R1A, PPP2R1B, ADSS, TSPO, SRI, GSTT1, SERPINB1, CORO1A, S100A7, PRKAR2B, FGF9, SDC4, DNAJA1, YWHAB, SFN, S100A11, PRDX2, GK, DCTD, STX2, CTH, LSP1, DUT, ABCC1, MAN1A1, GALNS, RNASE4, SHMT1, HSPA4, PRSS3, GPC1, CTNNB1, PHB, RDX, RPL22, THBS4, KRT9, FBN1, PCK1, MYH9, ACTN2, BSG, TIMP3, MYH11, GLRX, CHI3L1, TRIM23, ATP5C1, RPL4, NUDT1, PGM1, ACVR1B, SERPINB5, SERPINF1, DLST, GPX4, SCNN1A, SRP14, HPCAL1, TAGLN2, TALDO1, RBMX, LIPA, COL15A1, COL18A1, CAPG, IL6ST, CCT6A, MDH1, MDH2, EIF2S3, AQP2, MNDA, WNT5A, PTGDS, CSK, PRKCI, ACTR1B, ECI1, AKR1C3, DPP6, LIFR, ECE1, SLC1A4, NAMPT, PPIC, VDAC2, ACADSB, CRKL, NSF, RPL5, RPL28, RPS9, RPS5, RPS10, GNPDA1, IQGAP1, CAPZB, ALDH1A3, LGALS7, ATP5O, CXCL12, SERPINB4, PRRC2A, IDH2, PITPNB, CD97, MAPKAPK2, ALDH9A1, RPL34, TGM4, FASN, CCT3, ALDH7A1, SRP9, SARS, PSMB3, COMP, TMED10, HINT1, RARRES1, FHIT, SEPP1, HNMT, GNAQ, GNG4, GDI2, GATM, SLC26A2, SERPINB9, SERPINH1, TNFSF10, BCAM, PPT1, RPL14, CCT8, ANXA11, RAB5C, RAB7A, RAB9A, RAB27A, SCNN1G, PLCD1, DUSP3, SSR4, TPMT, ALDH3A2, PSMD7, SGSH, ARSD, VAMP7, LUM, PGD, HNRNPM, RAP1GDS1, ARHGDIA, ARHGDIB, HRSP12, CAPZA1, SLC25A1, SUCLG1, COPA, CTSC, PTTG1IP, IST1, SUB1, POLG, CRISP3, RARS, HIRA, CACNA2D1, PRKAG1, ATP1B3, EPHB4, EPHB1, NAGLU, GALC, SLC12A2, CSE1L, VCP, HADHB, INHBC, CDH6, CDH11, CDH13, CDH15, SEC13, NPEPPS, SUMO3, EIF3B, BID, EIF6, WNT3, GEMIN4, MTPN, HIST1H2BD, ZNF445, ARPC4, CD81, TPI1, MYL6, ACTB, RAC3, EIF4A1, RPS20, S100A10, CDC42, DSTN, RAB2A, RAB5B, CXCR4, UBE2D3, UBE2M, ACTR3, ACTR2, RAP2B, RPS3A, RPL26, RPL15, RPL27, ATP6V0D1, RPL37A, RHOA, NCALD, HSPE1, LYZ, STXBP1, B2M, DAD1, NPC2, UFM1, AP1S1, NUTF2, RRAS2, RPS7, PPP1CA, PPP1CB, CALM2, NCS1, RPS8, RPS15A, RPS16, YWHAE, RPS14, RPS18, RPS13, RPS11, LSM6, SNRPD2, SNRPD3, PSMC6, RPL7A, RAB11A, PPP2CB, ACTA2, RHOB, RPL23A, HIST1H4A, HIST1H2BC, RAB1A, RAP1A, RPS25, RPS26, GNB1, GNB2, RPL30, RPL31, RPL10A, RPL11, PPIA, RPS27A, UBA52, GRB2, RAC1, VAMP2, GNAI1, YWHAZ, DYNLL1, SKP1, GNG5, EIF5A, RACK1, ACTG1, ACTG2, YBX1, TPM4, ACTC1, EEF1A1, TUBA1B, TUBA4A, TUBB4B, PAFAH1B2, HIST1H3D, HBB, HBA1, SIRPA, CCT2, OLR1, GSTO1, BLOC1S1, BTG2, GPLD1, LCN2, NUCB2, ABAT, RPL24, ARF1, ARF5, H3F3A, GNAS, DAB2, MUC5AC, FBLN2, HSPG2, PKD1, LRP2, PITPNA, SLC25A3, REEP5, SORD, SPTBN1, SRSF2, CTBS, FABP5, IFITM3, SLC7A5, XPC, OCRL, ALDH6A1, DSC2, MAP2K1, FKBP4, PLOD1, NUCB1, CREB5, DST, TGFBR3, PLAUR, MVK, CFHR1, GBE1, KRT17, GLO1, AKR1C1, SSBP1, YWHAH, PRKCD, COL14A1, GFPT1, EXOSC9, AOX1, APLP2, PRDX1, BAX, SRSF1, CRYZ, IL10RB, DDR1, SLC20A2, MFGE8, CD47, AHNAK, ZNF763, GALNT2, BST2, FUT2, ST3GAL1, ST3GAL4, KCNMA1, EFEMP1, FSTL1, STX4, CNTN1, PTPRJ, EPS8, DLG1, MYO1E, PTP4A2, ECH1, COASY, SPP2, MTAP, PRDX4, PSMD2, SEMA3B, DNAJC3, SELENBP1, STX3, UBE2V1, SNTB2, GOLGA4, ADAM9, FKBP5, MTM1, SQSTM1, TUBB3, ASAH1, DCTN2, PKD2, IQGAP2, SEMA5A, MTMR2, CUL3, CUL4B, ALCAM, SHROOM2, BLMH, TUBB2A, COTL1, HNRNPD, NID2, IL18, DAG1, DSG2, DYNC1H1, CTTN, FGL2, GALE, GAS6, WFDC2, SPARCL1, FAT1, NBR1, INPP5A, PLS1, GANAB, RFTN1, PTGR1, KPNB1, CLCA4, SEPT2, RAB3GAP1, EEA1, PDIA6, PAFAH1B3, PCOLCE, PTGES3, PPP2R4, QPRT, PCBP1, TCEB2, RHEB, ANGPT1, PPP1R7, FCN2, TGFBI, TRIP10, MYLK, SLC1A5, UBE2V2, STK11, STXBP2, NEDD8, ADIRF, ADIPOQ, RAB11B, SEPT7, IGFBP7, PDCD2, SLC15A2, LAMA4, MAPK14, CDC37, DPYSL2, FSCN1, DECR1, QPCT, HAGH, HIST2H2BE, LAMA3, PCK2, PTPRO, UGP2, ATP6V1F, TXNRD1, TMEM132A, SPHKAP, IAH1, HLA-DRB5, TKFC, ZSCAN23, ALDH1L2, ANO6, PABPC1L, GREB1, C11orf73, PLA1A, COBLL1, TAF1B, CYBRD1, IGSF11, MEST, MUM1L1, NHLRC3, GNAS, COLEC12, MUC21, FNBP1L, EYS, WLS, CROCC, STRIP1, CDC42BPA, LRRC16A, CD276, CPZ, STEAP4, DMKN, HIST2H2AA3, PTRHD1, LAIR1, LAMTOR1, TWF2, NAPEPLD, NIPBL, TCTN3, HIBCH, SLC39A4, OGFOD3, ATAD2, POTEE, CSPG4, SBSN, C5orf46, CES3, OLFM4, PLXDC2, PI16, KIAA1324, THSD4, GBP6, SLCO4C1, FAM65A, VPS13C, TUBA1A, H2AFV, BTN2A1, CYFIP1, COPS6, HIST3H2A, MON2, TMC6, HDDC2, C6orf120, DCXR, SDK1, HUWE1, TMED4, GALNT7, OAF, RTN4RL1, ALYREF, SERINC5, TAX1BP1, CAND1, SLC26A11, LSR, AEBP1, HID1, SLC44A2, TEX14, ZBTB8OS, FAM20C, CPNE9, PM20D2, ALDH16A1, KIAA0319L, ABI1, TMEM256, MPP5, SFRP1, GALNT4, MINK1, TAB3, ARRDC1, COMMD1, CD177, PDDC1, GOLM1, UXS1, RNF149, SERBP1, GSTCD, APPL2, ATP6V1C2, GPRC5A, CASC5, SVIP, INADL, ZNF420, TBC1D15, NT5C, SPPL2A, BPIFB1, SNX29, SCARB1, RAB2B, PDCD6IP, MITD1, N6AMT2, NUDCD2, SECTM1, BTN2A2, ITLN1, SLC44A1, PHIP, GPR98, SYNE2, AHCTF1, TTN, FAM3C, NDRG1, HSPH1, DOCK2, SORL1, ANP32B, TFG, RYR2, HTRA1, N4BP2L2, GGH, BCL2L2, KIFAP3, GLG1, SLC5A5, RAB8B, ATP6V0A1, EXT2, HIST1H2AC, HIST1H2BH, PTP4A1, HGD, MYDGF, MAL2, TMBIM1, C11orf52, TMEM106A, FAM162A, ARL8A, PTER, DOCK10, AP2M1, KCTD12, MVB12A, CYFIP2, SAT2, CPNE2, S100A16, OTUB1, PGM2, ZNF486, ABHD14B, CPB2, ITCH, LOXL4, PDLIM2, HS6ST2, CLIC6, PGLYRP2, NEDD4L, VPS35, SNX18, MYADM, SERINC2, SPEN, FAM129B, MUC4, NEU1, MPHOSPH8, P2RX4, SERPINI1, S100A13, DNAJC7, PHB2, COPS8, CHP1, COL12A1, TM9SF2, CIB1, CCT7, SH3GL2, RARRES2, OMD, SEMA3C, GDF15, AIF1L, CORO1B, CPPED1, SDF4, FAM213A, ERP44, LXN, AGMAT, PRADC1, UPK3B, H2AFJ, FUCA2, DHRS4, SPON2, TUBB6, PDCD10, DDX23, BDH2, ABHD6, MLPH, DUSP26, DUSP23, GGACT, NUDT9, ACAT2, C1QTNF3, TMEM59, OSBPL1A, CADM1, FUT8, CDHR2, PARD6B, UACA, RAB34, FAM129A, UBXN6, TINAGL1, PDGFD, CTDSP1, NAA50, IQCG, CRISPLD2, TOLLIP, RACGAP1, WWP1, RAB1B, C11orf54, NAPB, SDCBP2, CYSTM1, TRPV6, WNT5B, EHD4, SPTBN4, SH3BGRL3, ALDH8A1, SLC38A1, DHX36, PPA2, CRISPLD1, PABPC3, GHITM, BOLA2, MUC13, CHMP4B, TOR3A, TUBB1, RHOJ, GLIPR2, GSTO2, METTL7A, MOB1A, SCPEP1, CACYBP, ROBO2, TMEM8A, CD248, RETN, APMAP, CD209, ABCB6, VTA1, CD320, ACOT13, PLCB1, CRTAC1, GPRC5C, RTN4, HINT3, XPNPEP3, MAN1C1, ASH1L, MXRA5, PDGFC, DUOX2, AASDHPPT, PLSCR4, CDC42SE2, PHPT1, SERINC1, LTBP3, TM7SF3, ECHDC1, GINM1, TMEM106B, LIN7C, ARL8B, C1orf123, B3GNT2, HAO2, UGGT1, ERAP1, CISD1, CLIC5, GLTP, GPRC5B, MAT2B, ITSN2, C1RL, CRIM1, MPP6, NDUFA13, H2AFY2, SH3BP4, ARHGAP23, MBD5, ANKFY1, SUCLA2, SPRR3, CLCF1, SPAST, VPS29, EIF3K, GRHPR, CTSZ, DNAJB9, CTSF, UQCR10, DNAJB4, KL, MIOX, DMBT1, FETUB, LAMTOR3, PCYOX1, SLC7A8, BAIAP2L1, ATP6V1H, SERPINB13, PLXNA1, GNPTG, TNIK, PILRA, NUDT5, VAV3, PCOLCE2, RAB21, RAB22A, RAB23, MYO5B, FZD4, MGAT4A, EPDR1, MYO6, PPT2, SNX12, NDRG2, PCDHGC3, SLC6A14, STUB1, PROCR, MINPP1, THSD7A, RIMS2, PA2G4, RUVBL2, PIN4, PLAA, RUVBL1, ST3GAL6, VDAC3, VSIG4, ITM2B, MAN2B2, GSTK1, LAMTOR2, CRYL1, CARHSP1, THRAP3, DERA, SH3GLB1, CAB39, HBS1L, TLN1, KIF3A, MYO5A, HYOU1, SAMM50, HSPB11, ATP6V1D, GMPPB, MMP24, CDC42BPB, SNX9, LYVE1, HEBP2, PSAT1, F11R, CPQ, ADGRG1, STK24, WNT6, TEX264, NCOA3, SLC4A4, PCLO, WASF2, ENPP4, LOC440434

GO:0070083

CC

clathrin-sculpted monoamine transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle.

SYT1, VAMP2, SLC18A2

GO:0070110

CC

ciliary neurotrophic factor receptor complex

A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR.

IL6R, IL6ST

GO:0070176

CC

DRM complex

A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification.

LIN52

GO:0070187

CC

telosome

A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Schizosaccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1.

TERF1, ACD, POT1

GO:0070195

CC

growth hormone receptor complex

A receptor complex that consists of two identical subunits and binds growth hormone.

GHR

GO:0070274

CC

RES complex

A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p.

BUD13, RBMX2

GO:0070369

CC

beta-catenin-TCF7L2 complex

A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.

CTNNB1, TCF7L2

GO:0070382

CC

exocytic vesicle

A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.

IGF1, RAB27A, DPYSL3, SYTL5, SYTL4, SYTL2

GO:0070390

CC

transcription export complex 2

A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sus1p and Cdc31p.

ENY2

GO:0070419

CC

nonhomologous end joining complex

A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends.

XRCC5, PRKDC, XRCC4, DCLRE1C

GO:0070435

CC

Shc-EGFR complex

A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway.

EGFR

GO:0070436

CC

Grb2-EGFR complex

A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway.

GRB2, TNK2

GO:0070449

CC

elongin complex

A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits.

TCEB1, TCEB2

GO:0070461

CC

SAGA-type complex

A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.

TADA2B, SGF29, USP22

GO:0070469

CC

respiratory chain

The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

UQCRHL, UQCRQ, UQCR11, CYC1, CYCS, HIGD1A

GO:0070522

CC

ERCC4-ERCC1 complex

A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae.

ERCC1, ERCC4

GO:0070531

CC

BRCA1-A complex

A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.

BRCA1, BRCC3, BARD1

GO:0070545

CC

PeBoW complex

A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.

BOP1, WDR12, WDR37

GO:0070552

CC

BRISC complex

A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains.

BRCC3, FAM175B

GO:0070554

CC

synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof).

CPLX2

GO:0070557

CC

PCNA-p21 complex

A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication.

PCNA, CDKN1A

GO:0070578

CC

RISC-loading complex

A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.

ZFP36, AGO4, AGO2, DICER1

GO:0070603

CC

SWI/SNF superfamily-type complex

A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP.

ATRX

GO:0070618

CC

Grb2-Sos complex

A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.

KHDRBS1

GO:0070652

CC

HAUS complex

A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex.

HAUS5, HAUS6, HAUS1, HAUS7, HAUS4, HAUS2

GO:0070685

CC

macropinocytic cup

A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin.

SNX5

GO:0070688

CC

MLL5-L complex

A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively.

OGT, PPP1CC, ACTB, PPP1CA, PPP1CB, STK38, KMT2E

GO:0070695

CC

FHF complex

A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex).

HOOK3, HOOK2, AKTIP

GO:0070724

CC

BMP receptor complex

A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits.

BMP2

GO:0070761

CC

pre-snoRNP complex

A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes.

NOP56, NUFIP1

GO:0070762

CC

nuclear pore transmembrane ring

A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex.

NDC1

GO:0070765

CC

gamma-secretase complex

A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.

TMED10, PSEN1, APH1B, APH1A

GO:0070776

CC

MOZ/MORF histone acetyltransferase complex

A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.

KAT6B, KAT6A, MEAF6

GO:0070820

CC

tertiary granule

A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells.

STX7, ADAM8, STXBP2

GO:0070821

CC

tertiary granule membrane

The lipid bilayer surrounding a tertiary granule.

SLC11A1

GO:0070822

CC

Sin3-type complex

Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.

BRMS1L, SUDS3

GO:0070826

CC

paraferritin complex

A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme.

SLC11A2

GO:0070847

CC

core mediator complex

A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

MED14, MED6, MED4

GO:0070852

CC

cell body fiber

A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.

ASS1, PENK, SRD5A1, SRD5A2, KCNJ11, SPTBN4

GO:0070860

CC

RNA polymerase I core factor complex

A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.

TAF1B

GO:0070876

CC

SOSS complex

A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80.

INTS3, NABP1, NABP2, INIP

GO:0070937

CC

CRD-mediated mRNA stability complex

A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, IGF2BP1 and at least four additional proteins: HNRNPU, SYNCRIP, YBX1, and DHX9.

SYNCRIP, YBX1, HNRNPU

GO:0070938

CC

contractile ring

A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles.

PRC1, DAG1, KIF20B

GO:0070971

CC

endoplasmic reticulum exit site

An endoplasmic reticulum part at which COPII-coated vesicles are produced.

PDCD6, SEC31A, APOB, PDCD6IP, YIPF5, TMED5

GO:0071001

CC

U4/U6 snRNP

A ribonucleoprotein complex that contains base-paired U4 and U6 small nuclear RNAs.

PPIH, SART3

GO:0071004

CC

U2-type prespliceosome

A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.

PRPF40A, LUC7L3, SNRPC, SNRPB, SNRPN, PRPF39, LUC7L, LSM7, LUC7L2

GO:0071006

CC

U2-type catalytic step 1 spliceosome

A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs.

CWC22, RBM22

GO:0071007

CC

U2-type catalytic step 2 spliceosome

A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.

RBM22

GO:0071008

CC

U2-type post-mRNA release spliceosomal complex

A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs.

DHX15, GCFC2

GO:0071010

CC

prespliceosome

A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex.

SNRPC, SNRPD1, SNRPD3, CRNKL1

GO:0071011

CC

precatalytic spliceosome

A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.

PLRG1, SON, SNU13, LSM3, SNRPD1, SNRPD2, SNRPD3, SNRNP35, AGGF1, SNRNP27, PRPF31, SNRNP40, SF3B5, CRNKL1, LSM2, RBMX2, SF3B6

GO:0071012

CC

catalytic step 1 spliceosome

A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs.

CRNKL1

GO:0071013

CC

catalytic step 2 spliceosome

A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.

HNRNPR, PLRG1, SYNCRIP, HNRNPC, HNRNPA1, SNRPA1, SNRPB, DDX5, HNRNPA2B1, HNRNPH1, RBMX, SKIV2L2, HNRNPA3, HNRNPM, SNRPF, LSM3, SNRPD1, SNRPD2, SNRPD3, SNRPN, HNRNPU, SRSF1, SF3A3, PRPF4B, CWC27, ALYREF, SRRM1, SNRNP40, CDC5L, DDX23, CRNKL1, PNN, DHX35, CWC22, RBM22, CWC15, LSM7, PRPF19, PPIE, SRRM2, LSM2, RBMX2, SF3B6, RBM8A

GO:0071014

CC

post-mRNA release spliceosomal complex

A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5.

CRNKL1

GO:0071021

CC

U2-type post-spliceosomal complex

A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5.

PRPF18

GO:0071062

CC

alphav-beta3 integrin-vitronectin complex

A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin.

VTN, ITGB3, ITGA5

GO:0071065

CC

alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex

A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1.

VCAM1, ADAM8

GO:0071133

CC

alpha9-beta1 integrin-ADAM8 complex

A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8.

ADAM8

GO:0071141

CC

SMAD protein complex

A protein complex that consists of SMAD proteins; may be homomeric or heteromeric.

SMAD9, HMGA2, SMAD3, SMAD4, SMAD2, SMAD1, SMAD5

GO:0071144

CC

SMAD2-SMAD3 protein complex

A heteromeric SMAD protein complex that contains SMAD2 and SMAD3.

SMAD3, SMAD2

GO:0071159

CC

NF-kappaB complex

A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.

RELA

GO:0071203

CC

WASH complex

A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53.

WASH1, CAPZB, CAPZA1, CCDC53

GO:0071204

CC

histone pre-mRNA 3'end processing complex

A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1.

SYNCRIP, SNRPB, YBX1, SLBP

GO:0071339

CC

MLL1 complex

A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.

RBBP5, INO80C, MGA, BAP18, PRPF31, PHF20, SENP3, CHD8, ASH2L, RUVBL2, RUVBL1, LAS1L

GO:0071437

CC

invadopodium

A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate.

WASH1, FSCN1, RUFY3

GO:0071438

CC

invadopodium membrane

The portion of the plasma membrane surrounding an invadopodium.

ITGB1, ITGA3, DPP4, PLAUR

GO:0071439

CC

clathrin complex

A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface.

CLTA

GO:0071458

CC

integral component of cytoplasmic side of endoplasmic reticulum membrane

The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane.

PKD2, SPPL3, SPPL2A, HM13

GO:0071540

CC

eukaryotic translation initiation factor 3 complex, eIF3e

An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.

EIF3A

GO:0071541

CC

eukaryotic translation initiation factor 3 complex, eIF3m

An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m.

EIF3B, EIF3A

GO:0071547

CC

piP-body

A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway.

PIWIL4, TDRD9

GO:0071556

CC

integral component of lumenal side of endoplasmic reticulum membrane

The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane.

HLA-B, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, HLA-E, HLA-DRB4, HLA-G, HLA-DPA1, CALR, CANX, HLA-A, HLA-F, BCAP31, HLA-DRB3, PKD2, HLA-DRB5, SPPL3, SPPL2A, HM13

GO:0071561

CC

nucleus-vacuole junction

An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p.

PIK3R4

GO:0071564

CC

npBAF complex

A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.

ARID1A, ACTL6A, SMARCA2, SMARCA4, SMARCD3, SMARCC2, PHF10, SMARCC1, SMARCD1

GO:0071565

CC

nBAF complex

A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

ARID1A, SMARCA2, SMARCA4, SMARCD3, ARID1B, SMARCC2, DPF3, SMARCC1, SMARCD1

GO:0071595

CC

Nem1-Spo7 phosphatase complex

A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p.

CTDNEP1, CNEP1R1

GO:0071598

CC

neuronal ribonucleoprotein granule

A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.

PQBP1, FMR1, UHMK1

GO:0071665

CC

gamma-catenin-TCF7L2 complex

A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.

JUP