GO:0031465

CC

Cul4B-RING E3 ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits.

RBX1, CUL4B, DTL

GO:0031466

CC

Cul5-RING ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.

RBX1, TCEB2, CUL5

GO:0031467

CC

Cul7-RING ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein.

RBX1, SKP1, CUL7

GO:0031501

CC

mannosyltransferase complex

A complex that posseses mannosyltransferase activity.

DPM3

GO:0031510

CC

SUMO activating enzyme complex

A conserved heterodimeric complex with SUMO activating enzyme activity.

SAE1

GO:0031512

CC

motile primary cilium

A primary cilium which may contain a variable array of axonemal microtubules and also contains molecular motors. Motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization.

GLI2, PKD1, PKD2, DYNC2LI1, DNAH11, IFT46

GO:0031513

CC

nonmotile primary cilium

A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules.

DRD2, TUBG1, NPY2R, PKD2, SEPT2, SEPT7, AHI1, CEP89, ANO2

GO:0031514

CC

motile cilium

A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles.

CCDC42B, NPHP1, ANXA1, PRKACA, MAK, SCNN1A, SORD, SPA17, HIF1A, RSPH4A, KLC3, CCDC103, C6orf165, IQUB, MNS1, IFT81, RSPH1, IFT74, FOPNL, CEP89, IFT27, BBS2, IQCG, SPAG4, MKKS, IFT46, TEKT2, INTU, DAAM1

GO:0031515

CC

tRNA (m1A) methyltransferase complex

A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer.

TRMT6

GO:0031519

CC

PcG protein complex

A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.

CBX7, YY1, SKP1, RING1, PCGF3, PCGF5, PHC3, SCML2

GO:0031523

CC

Myb complex

A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression.

MYBL2, FLNA

GO:0031526

CC

brush border membrane

The portion of the plasma membrane surrounding the brush border.

KCNK1, ATP8B1, SLC22A5, HSP90AA1, HSP90AB1, B4GALT1, FOLR1, CD36, CA4, SLC11A2, SLC7A9, LRP2, GNA12, CYBRD1, SLC27A4, ITLN1, SLC46A1, TRPM6, CDHR2, PEMT, SLC6A14

GO:0031527

CC

filopodium membrane

The portion of the plasma membrane surrounding a filopodium.

ITGB3, ITGAV, DMD, GAP43, ITGA3, NF2, PDPN, SYNE2, TTYH1, MYO10

GO:0031528

CC

microvillus membrane

The portion of the plasma membrane surrounding a microvillus.

ITGB3, ITGAV, EZR, S100P, CTNNB1, PDPN, MUC20, SCARB1, CDHR2

GO:0031588

CC

nucleotide-activated protein kinase complex

A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).

PRKAR1A, PRKAR2A, PRKAG1, PRKAA2, SESN2, PRKAG3

GO:0031594

CC

neuromuscular junction

The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.

MUSK, SYNGR2, SYNGR3, FCHSD2, APP, ITGB1, SERPINE2, PRKAR1A, PRKACA, DES, F2R, MYH9, PSEN1, EPHA4, CDH15, HDAC4, CDK5, NRG1, ANK3, DLG1, SNTA1, CAMK2D, POSTN, SV2A, SYNC, PDZRN3, COLQ

GO:0031595

CC

nuclear proteasome complex

A proteasome found in the nucleus of a cell.

PSMD12, PSMC3, PSMC2, PSMC4, PSMC1, PSMC6, UBQLN4

GO:0031597

CC

cytosolic proteasome complex

A proteasome complex found in the cytosol of a cell.

IDE, PSMC3, PSMC2, PSMC4, PSMC1, PSMC6, UBQLN4, UCHL5

GO:0031616

CC

spindle pole centrosome

A centrosome from which one pole of a mitotic or meiotic spindle is organized.

AURKA, NPM1, FAM175B, DLGAP5, AURKB, TBCCD1, NDE1

GO:0031618

CC

nuclear pericentric heterochromatin

Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.

NCAPD3, CBX5, CBX3, IKZF1, ESCO2

GO:0031672

CC

A band

The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.

PPP1R12A, PPP1R12B, MYL4, HDAC4, MYL7, ANK2, KAT2B, MYH2

GO:0031673

CC

H zone

A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments.

DST

GO:0031674

CC

I band

A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.

BIN1, NEBL, ALDOA, ACTC1, MTM1, ANKRD1, TTN, KAT2B

GO:0031680

CC

G-protein beta/gamma-subunit complex

The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange.

GNG5

GO:0031838

CC

haptoglobin-hemoglobin complex

A protein complex formed by the stable binding of a haptoglobin to hemoglobin.

HP, HBB, HBA1

GO:0031901

CC

early endosome membrane

The lipid bilayer surrounding an early endosome.

WASH1, HSD17B6, STX7, SNX3, ATP9A, LRP6, STAM2, DKK1, SNX4, EGFR, HLA-B, ANXA1, NTRK1, FCGR1A, CFTR, HLA-E, HLA-G, HLA-A, HLA-F, EPS15, RAB5C, CLCN3, CLCN4, EPHB1, EPHA4, SNX16, RAB5B, B2M, RAC1, OCRL, CAV1, SNX1, MTMR2, EEA1, MARCH8, WLS, ZFYVE16, FGD2, APPL2, TMEM163, MARCH1, SNX19, SLC9A6, FCGR1B, STAM, SNX21, PMEPA1, EHD4, PLEKHF2, TMEM165, MTMR4, LAMP5, SNX6, PIKFYVE, SNX5

GO:0031902

CC

late endosome membrane

The lipid bilayer surrounding a late endosome.

VPS37C, GOSR2, NPC1, CHMP2A, VPS4B, HLA-DRA, NTRK1, ANXA2, ANXA6, LAMP2, HLA-DRB4, HLA-DMB, SLC11A1, SLC11A2, RAB7A, CLCN3, CLCN4, VAMP7, SNX16, RHOB, HLA-DRB3, IFITM3, PLD1, STARD3, MMD, HLA-DRB5, LAMTOR1, KIAA1324, VPS37A, MARCH1, SPPL2A, MITD1, ABCA5, ARL8A, MVB12A, OSBPL9, OSBPL11, TMEM59, AP5M1, CHMP4B, TMEM165, TMEM106B, ARL8B, TMEM9, VTI1B, PIKFYVE

GO:0031904

CC

endosome lumen

The volume enclosed by the membrane of an endosome.

JAK2, INS, APOB, APP, PRLR, AP4S1

GO:0031905

CC

early endosome lumen

The volume enclosed by the membrane of an early endosome.

B2M, LNPEP

GO:0031931

CC

TORC1 complex

A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.

LARP1, MLST8

GO:0031932

CC

TORC2 complex

A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.

SESN2, RPL23A, RICTOR, MAPKAP1, MLST8, PINK1

GO:0031933

CC

telomeric heterochromatin

Heterochromatic regions of the chromosome found at the telomeres.

ATRX, LRWD1

GO:0031941

CC

filamentous actin

A two-stranded helical polymer of the protein actin.

MYO1C, TPM1, TMSB15A, FLNA, RAC3, TMSB4X, ACTG1, TMSB10, TPM4, PKD2, IQGAP2, DPYSL3, FSCN1, LRRC16A, FERMT1, MYO6

GO:0031965

CC

nuclear membrane

Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

HAX1, CLIC1, IPO5, TOR1A, TNPO2, XPO1, SLC16A3, NUPL2, PLRG1, RANBP6, CDC14B, MRPS14, PDCD6, NUP155, NDUFB4, TNKS, CTDNEP1, EGFR, CST3, LMNA, GAPDH, ANXA4, ALOX5, BCL2, CDK4, TPR, HSD17B1, RCC1, LMNB1, NR4A1, CCND2, TSPO, GRK5, ADRA1A, ADRA1B, NUDT1, NUP62, PTGDS, RANGAP1, MRPL19, PSEN1, NUP153, RANBP2, SEPHS1, GNAQ, EMD, NUP107, NUTF2, YBX1, DMPK, AKAP6, LPIN1, KPNB1, WTAP, PCM1, RPS6KA2, TMEM176B, TMEM97, FAM76B, RRP12, CEP170, NSMF, CERS6, QSOX2, TMC6, MTDH, DGKH, NUP93, INTS1, CERS5, TMEM57, CNEP1R1, NUP35, CEP70, PUM2, RB1CC1, NUP210, IPO4, SYNE2, AHCTF1, NUP205, DNAJC1, PRICKLE1, CMTM3, RBM15, DCTN5, NDC1, DHRS4, PHF20, NUP58, NUP85, REPIN1, OSBPL8, OSBPL6, EPC1, AKIRIN1, CERS4, PLCB1, TXLNG, TMEM38B, DTL, ZNF224, HACD3, VAPA, SPAST, SUN2, HN1, MRTO4, NUP50, NRXN1, FZR1, MYO6, NPIPA1, WDR3, RNF6, KLHDC2, TNPO3, CEPT1, SLC30A1

GO:0031966

CC

mitochondrial membrane

Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

C7orf73, NDUFAB1, NDUFA1, NDUFA2, NDUFB6, ANXA1, CLU, PRKCA, SDHB, NME2, HSD3B2, PLN, ATXN3, SORD, OGDH, BNIP3, ETFDH, COX20, RNF144B, MAVS, OMA1, COX14, CARD19, GPER1, SFXN3, CCDC90B, REEP1, NDUFAF4, NDUFA13, TMEM14C, PEMT, BOK, MAPK8IP1, STARD13

GO:0031981

CC

nuclear lumen

The volume enclosed by the nuclear inner membrane.

SYNE2

GO:0031982

CC

vesicle

Any small, fluid-filled, spherical organelle enclosed by membrane.

CLIC1, PIK3C2A, DYNC1I1, TSPAN4, CASK, STX7, RIPK2, VPS26A, TF, ANXA1, GAPDH, ANXA2, GSTP1, MIF, PKM, IFNGR1, EZR, MUC1, RAB3B, CFL1, PLN, STOM, TKT, SERPINB3, LRPAP1, AKT1, TAGLN2, ECE1, GDI2, CD81, MYL6, SNAP25, RHOA, CALM2, RAB11A, GNB2, VAMP2, AHNAK, EPS8, DYNC1I2, PICALM, DCTN2, SNX1, GPRC5A, ARHGEF2, RAB39B, MVB12A, PACRG, ALS2, MUC4, CIB1, RAB34, CHMP4B, LGR6, ATP13A2, GPRC5C, SYBU, VAPA, VTI1B, RABGEF1, NRXN1, CORO1C, SLC6A14, LAMP3, MYO5A

GO:0031985

CC

Golgi cisterna

Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex.

SORL1, RAB34

GO:0031988

CC

membrane-bounded vesicle

Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.

BGLAP, BMP1, BMP6, SLC47A1

GO:0032002

CC

interleukin-28 receptor complex

A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1).

IL10RB

GO:0032009

CC

early phagosome

A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.

SNX3, SYK, SYT11

GO:0032010

CC

phagolysosome

A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.

NCF2, ADAM8, NCF4

GO:0032039

CC

integrator complex

A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II.

SHFM1, CPSF3L, INTS3, INTS1, INTS4, INTS7, INTS10, INTS6

GO:0032040

CC

small-subunit processome

A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

NOP56, UTP20, SNU13, RPS7, TBL3, NGDN, WDR36, EMG1, UTP23, DCAF13, WDR3, FCF1, UTP18

GO:0032044

CC

DSIF complex

A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.

SUPT5H

GO:0032045

CC

guanyl-nucleotide exchange factor complex

A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.

RAP1A, PDE3B, KNDC1, ELMO1

GO:0032059

CC

bleb

A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.

TPM1, PANX1, SDF4, FHOD1

GO:0032116

CC

SMC loading complex

A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved.

NIPBL

GO:0032127

CC

dense core granule membrane

The lipid bilayer surrounding a dense core granule.

ADAM8

GO:0032133

CC

chromosome passenger complex

A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.

AURKA, BIRC5, CDCA8, AURKB

GO:0032144

CC

4-aminobutyrate transaminase complex

A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity.

ABAT

GO:0032154

CC

cleavage furrow

The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.

PLK4, RAB11FIP3, STAMBP, ITGB1, RALA, NF2, RDX, MYH9, PPP1CC, RHOA, RAB11A, RHOB, SEPT6, SEPT2, MYLK, SEPT7, PKN1, PKN2, CEP55, MASTL, ZFYVE19, RACGAP1, ECT2, NDE1, LIMA1, RAB21

GO:0032173

CC

septin collar

A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell.

SEPT6

GO:0032279

CC

asymmetric synapse

A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory.

CHRM2, CHRM3, ADORA1, ARFGEF2

GO:0032280

CC

symmetric synapse

A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typcially inhibitory.

PENK, CHRM2, ARFGEF2

GO:0032281

CC

AMPA glutamate receptor complex

An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.

GRIA4, DLG4, SHISA6, ABHD12, CACNG8, ABHD6

GO:0032299

CC

ribonuclease H2 complex

A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p.

RNASEH2A, RNASEH2B

GO:0032300

CC

mismatch repair complex

Any complex formed of proteins that act in mismatch repair.

MLH3

GO:0032301

CC

MutSalpha complex

A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.

MSH2, MSH6

GO:0032302

CC

MutSbeta complex

A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3.

MSH3, MSH2

GO:0032311

CC

angiogenin-PRI complex

A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis.

ANG, RNH1

GO:0032389

CC

MutLalpha complex

A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.

MLH1, PMS1

GO:0032391

CC

photoreceptor connecting cilium

A nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments.

NPHP1, C21orf2, MAK, SEPT2, FAM161A, KIFAP3, IFT122, SPATA7

GO:0032398

CC

MHC class Ib protein complex

A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.

HLA-E

GO:0032419

CC

extrinsic component of lysosome membrane

The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

RAB7A

GO:0032420

CC

stereocilium

An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.

ATP8B1, RDX, MPP1, EPS8, TWF2, GPR98, BBS2, CLIC5

GO:0032432

CC

actin filament bundle

An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.

CRYAB, LCP1, PLS1, FAM101A, FAM101B

GO:0032433

CC

filopodium tip

The end of a filopodium distal to the body of the cell.

EPHB1, FMR1, NLGN1, CIB1, TTYH1, MYO10, MYO5A

GO:0032437

CC

cuticular plate

A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted.

SPTBN1

GO:0032444

CC

activin responsive factor complex

A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor.

SMAD4, SMAD2

GO:0032449

CC

CBM complex

A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation.

BCL10, CARD10

GO:0032541

CC

cortical endoplasmic reticulum

A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.

ASPH

GO:0032545

CC

CURI complex

A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p.

RRP7A

GO:0032580

CC

Golgi cisterna membrane

The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex.

GOLGA8A, GPR89A, GOLIM4, ASAP2, B4GALT5, B4GALT4, GPR89B, B4GALT1, ST6GAL1, FUT1, FUT4, BCAP31, NUCB1, GOLGA2, GALNT2, GALNT1, FUT2, ST3GAL1, ST3GAL3, ST3GAL4, TMED2, ST3GAL2, CHSY3, CHSY1, HACE1, UXS1, CSGALNACT1, GOLGA1, YIPF5, APH1A, ST6GAL2, ARAP1, FUT8, INPP5E, B4GALT6, NAGPA, RAB21, TMED3, SAR1B

GO:0032584

CC

growth cone membrane

The portion of the plasma membrane surrounding a growth cone.

GAP43, NECTIN1, EXOC4, LAMP5, EXOC7, TRPV2

GO:0032585

CC

multivesicular body membrane

The lipid bilayer surrounding a multivesicular body.

RAB27B, PMEL, RAB27A, ATP13A2, NDFIP2

GO:0032587

CC

ruffle membrane

The portion of the plasma membrane surrounding a ruffle.

MYO1C, SPRY2, PIP5K1C, PDE9A, ITGB3, ITGB1, ITGAV, HSP90AA1, ITGA5, TPM1, FGR, LCP1, EZR, NME1, ARF4, CFL1, APC, AKT2, NF2, TIRAP, RAC1, EEF1A1, ADAM17, TWF1, PTPRJ, EPS8, TIAM1, IFIT5, KANK1, PLEKHO1, THEM4, RASGRP2, FGD2, PDPN, C2CD5, WWC1, ARHGEF2, SH3YL1, SPATA13, DLC1, CIB1, AIF1L, FERMT1, INPP5K, PACSIN1, SPRY4, TRPV4, ARHGEF4, MYO6, MACF1, TLN1

GO:0032588

CC

trans-Golgi network membrane

The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.

SCAMP2, STX6, VAMP4, LGR5, RHOBTB3, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, APP, CLTA, IGF2R, HLA-DRB4, HLA-DPA1, RAB9A, ARFIP1, AP1S2, AP1S1, HLA-DRB3, AP1B1, RAB31, COG2, VAMP3, HLA-DRB5, RABEPK, VPS52, MARCH1, USP6NL, LGR6, TMEM165, COG6, AP4S1, MMP24

GO:0032590

CC

dendrite membrane

The portion of the plasma membrane surrounding a dendrite.

ATF4, WLS, GABARAPL1, LAMP5

GO:0032591

CC

dendritic spine membrane

The portion of the plasma membrane surrounding a dendritic spine.

ATP2B1, TRPV1, GPER1

GO:0032592

CC

integral component of mitochondrial membrane

The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

BID, MFF, ABCB10

GO:0032593

CC

insulin-responsive compartment

A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2.

SLC2A4, RAB4B, DENND4C, MYO5A

GO:0032777

CC

Piccolo NuA4 histone acetyltransferase complex

A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p.

EPC2, EPC1, ING3

GO:0032783

CC

ELL-EAF complex

A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae.

EAF1

GO:0032797

CC

SMN complex

A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus.

ZPR1, GEMIN4, FMR1, GEMIN5, GEMIN6, GEMIN8, DDX20

GO:0032798

CC

Swi5-Sfr1 complex

A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces).

SWI5

GO:0032807

CC

DNA ligase IV complex

A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p.

XRCC4

GO:0032809

CC

neuronal cell body membrane

The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.

ATP2B1, GABRA5, SLC4A8, FLRT1

GO:0032838

CC

cell projection cytoplasm

All of the contents of a cell projection, excluding the plasma membrane surrounding the projection.

AKR1B1

GO:0032839

CC

dendrite cytoplasm

All of the contents of a dendrite, excluding the surrounding plasma membrane.

ADA, CANX, MAPK1, DLG4, WLS, UHMK1, GABARAPL1

GO:0032937

CC

SREBP-SCAP-Insig complex

A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane.

INSIG1, SREBF2

GO:0032982

CC

myosin filament

A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.

MYH11, ACTG2, MYBPC1, MYH2, MYH4

GO:0032991

CC

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

CRTAP, PPIB

GO:0032993

CC

protein-DNA complex

A macromolecular complex containing both protein and DNA molecules.

SOX12, JUP, JUND, NFYB, KDM5A, CTNNB1, DDIT3, HMGA2, HHEX, NFYC, CHD4, SUZ12, TCF7L2

GO:0032994

CC

protein-lipid complex

A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other.

PEX3

GO:0032996

CC

Bcl3-Bcl10 complex

A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus.

BCL3

GO:0033010

CC

paranodal junction

A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.

AKR1B1, SIRT2, JAM3

GO:0033017

CC

sarcoplasmic reticulum membrane

The lipid bilayer surrounding the sarcoplasmic reticulum.

ATP2A2, PLN, SRI, DMPK, ASPH, CAMK2D, ITPR2, RYR3, CHERP, SYNE2, RYR2, JSRP1, TMEM38B

GO:0033018

CC

sarcoplasmic reticulum lumen

The volume enclosed by the membranes of the sarcoplasmic reticulum.

CALU, CALR

GO:0033063

CC

Rad51B-Rad51C-Rad51D-XRCC2 complex

A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof.

RAD51C, RAD51D