| GO ID |
Ontology |
GO Term |
Term Definition |
Proteins |
|
GO:0005940
|
CC
|
septin ring
|
A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form.
|
SEPT6
|
|
GO:0005942
|
CC
|
phosphatidylinositol 3-kinase complex
|
A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
|
PIK3CD,
PIK3C2A,
PIK3R1,
PIK3CA,
PIK3CB,
PIK3C3
|
|
GO:0005943
|
CC
|
phosphatidylinositol 3-kinase complex, class IA
|
A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.
|
PIK3R1,
PIK3CA
|
|
GO:0005944
|
CC
|
phosphatidylinositol 3-kinase complex, class IB
|
A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
|
PIK3CG
|
|
GO:0005945
|
CC
|
6-phosphofructokinase complex
|
A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known.
|
PFKL
|
|
GO:0005947
|
CC
|
mitochondrial alpha-ketoglutarate dehydrogenase complex
|
Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity.
|
DBT,
BCKDHA,
BCKDHB
|
|
GO:0005952
|
CC
|
cAMP-dependent protein kinase complex
|
An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.
|
PRKAR1A,
PRKAR2A,
PRKACA,
PRKAR2B
|
|
GO:0005953
|
CC
|
CAAX-protein geranylgeranyltransferase complex
|
A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
|
PGGT1B
|
|
GO:0005955
|
CC
|
calcineurin complex
|
A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.
|
PPP3CA,
ITPR1
|
|
GO:0005958
|
CC
|
DNA-dependent protein kinase-DNA ligase 4 complex
|
A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV.
|
PRKDC,
XRCC4,
XRCC6BP1
|
|
GO:0005960
|
CC
|
glycine cleavage complex
|
A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.
|
GCSH
|
|
GO:0005964
|
CC
|
phosphorylase kinase complex
|
An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.
|
PHKA2,
PHKA1
|
|
GO:0005967
|
CC
|
mitochondrial pyruvate dehydrogenase complex
|
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
|
DLAT,
PDK1
|
|
GO:0005968
|
CC
|
Rab-protein geranylgeranyltransferase complex
|
A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein.
|
CHM,
CHML,
RABGGTB
|
|
GO:0005969
|
CC
|
serine-pyruvate aminotransferase complex
|
An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate.
|
EEA1
|
|
GO:0005971
|
CC
|
ribonucleoside-diphosphate reductase complex
|
An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.
|
RRM1,
RRM2
|
|
GO:0008021
|
CC
|
synaptic vesicle
|
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
|
TOR1A,
SYNGR3,
STX11,
SNAPIN,
TH,
MME,
LAMP1,
SYN1,
RAB3B,
RAB5A,
SYT1,
MT3,
STX2,
SNCA,
VDAC2,
PPT1,
CLCN3,
SNAP25,
ATP6V0D1,
VAMP2,
DLG4,
CDK16,
APBA1,
SLC18A2,
STX4,
GRIN2A,
STX3,
CLN3,
MTMR2,
SEPT6,
RAB11B,
STXBP5,
SV2A,
SV2B,
DMXL2,
SYT11,
TRIM9,
NDEL1,
MFF,
SLC40A1,
VTI1B,
WDR7,
SNCAIP
|
|
GO:0008023
|
CC
|
transcription elongation factor complex
|
Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.
|
ELL2,
IKBKAP,
ELOF1,
ICE2,
ELP4,
EAF1,
ELP3,
AFF4,
NUFIP1,
TTF2
|
|
GO:0008024
|
CC
|
cyclin/CDK positive transcription elongation factor complex
|
A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
|
CCNT1,
CCNT2,
RB1
|
|
GO:0008043
|
CC
|
intracellular ferritin complex
|
A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains.
|
FTL,
FTH1
|
|
GO:0008074
|
CC
|
guanylate cyclase complex, soluble
|
Complex that possesses guanylate cyclase activity and is not bound to a membrane.
|
NPR2,
GUCY2D
|
|
GO:0008076
|
CC
|
voltage-gated potassium channel complex
|
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
|
KCNK1,
DPP6,
SNAP25,
CALM2,
VAMP2,
DLG4,
KCNA1,
KCNMA1,
KCNH2,
KCNC3,
CTTN,
KCNJ11,
KCNG3,
KCNV2,
KCNIP2,
KCNG1,
KCNK6
|
|
GO:0008091
|
CC
|
spectrin
|
Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.
|
SPTBN1,
SPTBN4
|
|
GO:0008180
|
CC
|
COP9 signalosome
|
A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
|
FLOT1,
HSP90AB1,
HSPA5,
HSPA6,
TMOD1,
HSPA1L,
MYH9,
GRB2,
DYNLL1,
AMOT,
COPS6,
AMOTL1,
DOCK7,
COPS8,
COPS7B
|
|
GO:0008250
|
CC
|
oligosaccharyltransferase complex
|
A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected.
|
DDOST,
STT3A,
DAD1,
STT3B,
OSTC
|
|
GO:0008274
|
CC
|
gamma-tubulin ring complex
|
A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule.
|
BRCA1,
MZT1,
MZT2A
|
|
GO:0008275
|
CC
|
gamma-tubulin small complex
|
A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex.
|
TUBGCP3,
CENPJ
|
|
GO:0008278
|
CC
|
cohesin complex
|
A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
|
RAD21,
WAPL,
CDCA5,
SMC3
|
|
GO:0008280
|
CC
|
cohesin core heterodimer
|
The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes.
|
SMC1A,
SMC3
|
|
GO:0008282
|
CC
|
ATP-sensitive potassium channel complex
|
A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.
|
KCNJ11
|
|
GO:0008290
|
CC
|
F-actin capping protein complex
|
A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.
|
CAPG,
CAPZB,
CAPZA1,
MTPN
|
|
GO:0008305
|
CC
|
integrin complex
|
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
|
ITGA10,
ITGB3,
ITGB2,
ITGB1,
ITGAV,
ITGA5,
ITGAM,
ITGB4,
ITGA2,
ITGAX,
ITGA3,
ITGB8,
MYH9,
ITGAE,
ITGA9,
ITGA11
|
|
GO:0008328
|
CC
|
ionotropic glutamate receptor complex
|
A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex.
|
DLG4,
DLG1
|
|
GO:0008352
|
CC
|
katanin complex
|
A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa).
|
KATNB1
|
|
GO:0008385
|
CC
|
IkappaB kinase complex
|
A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
|
MAP3K13,
MAP3K7,
ERC1,
PYCARD
|
|
GO:0008537
|
CC
|
proteasome activator complex
|
A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex.
|
PSME3
|
|
GO:0008540
|
CC
|
proteasome regulatory particle, base subcomplex
|
The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.
|
PSMD10,
PSMC3,
PSMC2,
PSMC4,
PSMC1,
PSMC6,
PSMD2
|
|
GO:0008541
|
CC
|
proteasome regulatory particle, lid subcomplex
|
The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.
|
PSMD11,
PSMD12,
PSMD3,
SHFM1
|
|
GO:0008622
|
CC
|
epsilon DNA polymerase complex
|
A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
|
POLE2,
POLE,
POLE4,
POLE3,
CHRAC1
|
|
GO:0008623
|
CC
|
CHRAC
|
An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair.
|
CHRAC1,
BAZ1A
|
|
GO:0009279
|
CC
|
cell outer membrane
|
A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
|
SLC11A1,
DAG1
|
|
GO:0009328
|
CC
|
phenylalanine-tRNA ligase complex
|
An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe).
|
FARSA
|
|
GO:0009330
|
CC
|
DNA topoisomerase complex (ATP-hydrolyzing)
|
Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity.
|
TOP2A
|
|
GO:0009331
|
CC
|
glycerol-3-phosphate dehydrogenase complex
|
An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate.
|
GPD2
|
|
GO:0009353
|
CC
|
mitochondrial oxoglutarate dehydrogenase complex
|
A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus.
|
MRPS36
|
|
GO:0009360
|
CC
|
DNA polymerase III complex
|
The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork.
|
CRCP
|
|
GO:0009368
|
CC
|
endopeptidase Clp complex
|
A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form.
|
CLPX,
CLPP
|
|
GO:0009841
|
CC
|
mitochondrial endopeptidase Clp complex
|
A Clp endopeptidase complex located in the mitochondrion.
|
CLPX
|
|
GO:0009897
|
CC
|
external side of plasma membrane
|
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
IGLL5,
TLR4,
SEMA7A,
GPC4,
ABCA1,
CLPTM1,
GSR,
ADA,
LDLR,
TNF,
CD4,
FGA,
FGB,
FGG,
TFRC,
CD74,
SERPINA5,
IL6,
ICAM1,
ITGB1,
ITGAV,
P4HB,
THBS1,
PTPRC,
ITGA5,
ANXA5,
KIT,
CD28,
LAMP1,
ACE,
NCAM1,
SELL,
SLC2A4,
B4GALT1,
CD36,
IL7R,
ITGA2,
LAG3,
SDC1,
VCAM1,
CD33,
S1PR1,
CD9,
ITGA6,
FAS,
ITGA3,
CD27,
CALR,
CD40LG,
CDH5,
CHRNA7,
BMPR1A,
TGFBR2,
ITGAE,
IL6ST,
IL12RB1,
ECE1,
MCAM,
CXCL12,
BCAM,
SCNN1G,
CLCN3,
EPHA5,
CDH13,
ANTXR2,
B2M,
CD83,
IL1RL1,
NRG1,
TGFBR3,
MFGE8,
ALCAM,
ADGRE1,
SPA17,
HFE,
AMOT,
CD276,
VTCN1,
RTN4RL1,
PDPN,
ADGRA3,
SCUBE1,
NLGN1,
TRPV1,
LILRB1,
STAB2,
NRCAM,
MAP3K5,
CD244,
HEG1,
TFR2,
TNFRSF11A
|
|
GO:0009898
|
CC
|
cytoplasmic side of plasma membrane
|
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
TH,
KIT,
G6PD,
JUP,
GM2A,
ATP2B1,
PTPN4,
MAP2K2,
RGS2,
GEM,
PTEN,
DLG1,
LDLRAP1,
PTP4A1,
PKP4,
ASPSCR1,
CHMP4B,
RAB21,
PTPN22
|
|
GO:0009925
|
CC
|
basal plasma membrane
|
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
MYO1C,
CLDN4,
TF,
MET,
ITGA6,
EPS15,
TEK,
DST,
ANK3,
PKD2,
ITGA9,
BMPR2,
LDLRAP1,
MUC20,
SLC23A2
|
|
GO:0009986
|
CC
|
cell surface
|
The external part of the cell wall and/or plasma membrane.
|
TLR4,
ADAM10,
NRP1,
PLXNB2,
CAPN5,
NRDC,
TYROBP,
FZD6,
GREM1,
TLR2,
SRPX2,
RAMP1,
RAMP3,
SDC3,
HMMR,
ENTPD6,
VAMP4,
LRP6,
CLSTN1,
CSPG5,
MPZL1,
BMP10,
GOT2,
EGFR,
PLG,
PLAU,
PLAT,
ADA,
PDGFB,
LDLR,
TGFA,
TGFB1,
TNF,
HLA-B,
HLA-DRA,
CRYAB,
APOA1,
FGA,
FGB,
FGG,
APOH,
AMBP,
TFRC,
TF,
ANXA1,
PDGFA,
PRNP,
CD74,
NTRK1,
APP,
ITGB3,
ITGB2,
ICAM1,
ITGB1,
ITGAV,
LPL,
CSF1R,
ANXA2,
HSP90AA1,
THBS1,
NGFR,
CD55,
SLC3A2,
HSP90AB1,
PTPRC,
MET,
MFI2,
ITGA5,
IL6R,
LGALS1,
HMGB1,
SPARC,
ANXA4,
PDGFRB,
FURIN,
TFPI,
CD28,
HSPD1,
CLU,
GHR,
HSPA5,
ITGAM,
MBL2,
RALA,
DMD,
IGF2R,
BMP2,
TDGF1,
CFTR,
NCAM1,
PDIA4,
HLA-E,
MIF,
CPM,
IDE,
IL1R1,
PVR,
FOLR1,
AREG,
CD46,
VEGFA,
CD1D,
ARSB,
TIMP2,
CD44,
ITGB4,
EPCAM,
PRLR,
CD36,
ITGA2,
CR1,
ITGB5,
SDC1,
PAM,
CD58,
VCAM1,
CD53,
HLA-DPA1,
ITGAX,
NT5E,
C5AR1,
FGFR2,
BGN,
FUT4,
ENPP1,
CA4,
MRC1,
ITGA6,
TNFSF4,
CXCR2,
CD24,
F2R,
FAS,
ITGA3,
ITGB8,
ACVR2A,
DPP4,
CALR,
PCSK6,
CD40LG,
ERP29,
PDIA3,
HLA-A,
HLA-F,
SLC6A1,
LRPAP1,
SDC4,
CDH5,
SDC2,
PHB,
ACVR1B,
TGFBR1,
WNT5A,
ADCYAP1R1,
SLC1A3,
SLC1A2,
SLC1A4,
NOTCH1,
SLC11A2,
PSEN1,
MMP16,
CLCN3,
VAMP7,
EPHA4,
EMP2,
SYNJ2BP,
CXCR4,
CXADR,
ADAM8,
ADAM17,
PKD1,
NDP,
HNRNPU,
TEK,
TGFBR3,
NOTCH2,
C1QBP,
KCNA1,
BST2,
KCNH2,
STX4,
CDH17,
GRIN2A,
HYAL2,
PTPRJ,
ANK3,
SLC39A6,
ADAM9,
IQGAP2,
BMPR2,
DSG2,
DIP2A,
PTPRK,
VAMP3,
ADIPOQ,
AOC3,
MICB,
MICA,
ANO6,
SFRP4,
CSPG4,
RTN4RL1,
LRRC8A,
SULF2,
SULF1,
SCUBE1,
SCUBE3,
NLGN4X,
NLGN1,
SFRP1,
PCSK9,
TSPAN14,
CYP2W1,
HM13,
ADAMTS15,
DEFB104A,
SCARB1,
GPR98,
TNR,
GHSR,
KISS1R,
SLC46A1,
DCBLD2,
HHIP,
HBEGF,
PHB2,
ERP44,
SLC46A2,
ULBP2,
WNT5B,
CLSTN2,
C10orf54,
TMEM206,
TRPV4,
RC3H2,
TNS1,
ROBO2,
APMAP,
CD209,
TNFRSF12A,
CD93,
PDGFC,
IL17RB,
CLDND1,
GPRC5B,
ADAMTS9,
ADAMTS7,
NRXN1,
INTU,
FZD4,
PROCR,
SLC7A11,
TLN1,
HILPDA,
TRPV2,
LIPG,
WNT6
|
|
GO:0010008
|
CC
|
endosome membrane
|
The lipid bilayer surrounding an endosome.
|
VPS37C,
TLR4,
RHOD,
GOLIM4,
AP3D1,
LEPROT,
ATP6V0E1,
TLR3,
IRAK2,
MAP3K7,
SNX3,
VPS4B,
VPS26A,
AP1G2,
EGFR,
LDLR,
HLA-DQA2,
HLA-DQA1,
HLA-DQB1,
TF,
APOB,
ERBB2,
INSR,
CD14,
UBC,
LAMP1,
HLA-DOB,
CD1D,
HLA-DPA1,
RAB5A,
UBA1,
MRC1,
CD68,
RAB7A,
IRAK1,
CLCN4,
CLCN5,
CLCN6,
ANTXR2,
UBE2D3,
ATP6V0D1,
RHOB,
RPS27A,
UBA52,
CD164,
TCIRG1,
SNX1,
GRB14,
ACAP2,
NCF4,
TAB1,
NTRK2,
WDR44,
WIPI1,
PARM1,
RABEPK,
VPS52,
TAB3,
COMMD1,
APPL2,
VPS37A,
TPCN2,
RFFL,
TBC1D5,
ATP6V0A1,
PMEPA1,
TMBIM1,
VPS35,
SNX18,
TM9SF2,
NDFIP1,
TMEM165,
ABCB6,
VTA1,
CD320,
EHD3,
ANKFY1,
VPS29,
SUN2,
LAMTOR3,
TBK1,
LAMP5,
GGA2,
GGA1,
RAB22A,
RAB23,
ITM2B,
PIKFYVE,
LAMTOR2
|
|
GO:0010369
|
CC
|
chromocenter
|
A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure.
|
OIP5,
CBX5,
CBX1,
FMR1,
CDCA8,
ESCO2,
MBD6,
AURKB,
MBD5
|
|
GO:0010494
|
CC
|
cytoplasmic stress granule
|
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
FAM195B,
DDX3X,
PQBP1,
STAU1,
EIF2S1,
EIF4E,
ZFP36,
TIA1,
YBX1,
G3BP1,
CIRBP,
CAPRIN1,
PUM1,
NUFIP2,
LSM14A,
PUM2,
ATXN2L,
KHSRP,
RBPMS,
FAM195A,
RBM4,
LIN28A,
MBNL1
|
|
GO:0012505
|
CC
|
endomembrane system
|
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
|
ACACB,
PIP5K1B,
PGRMC2,
BCL2L11,
PIP5K1C,
TBC1D4,
SLC2A10,
TBC1D8,
TBC1D3H,
SLC2A4,
ATP6V1B2,
JAK1,
JAK3,
RAC3,
TBC1D8B,
GRTP1,
TBC1D9B,
TBC1D3C,
NBEAL1,
TBC1D9,
RUFY3,
LAPTM4B,
TBC1D3,
MPP5,
RHEBL1,
TBC1D15,
PARD3,
CYB5D2,
DOCK2,
NSMAF,
USP6NL,
MAL2,
RUNDC1,
EVI5L,
ASPSCR1,
MAP1LC3B,
NRBP2,
AIG1,
CDC42EP3,
NENF,
TBC1D2B,
RABGAP1
|
|
GO:0012506
|
CC
|
vesicle membrane
|
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
|
SYNJ1,
ANXA4,
SLC2A4,
ACPP,
ATP2A2,
CLCN3,
GRB2,
ASPSCR1,
ATP13A2,
RAB21,
PIKFYVE
|
|
GO:0012507
|
CC
|
ER to Golgi transport vesicle membrane
|
The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.
|
GOSR2,
SEC22B,
SEC24D,
SEC31A,
TGFA,
HLA-B,
HLA-DRA,
HLA-DQA2,
HLA-DQA1,
HLA-DQB1,
CD74,
HLA-E,
HLA-DRB4,
FOLR1,
AREG,
HLA-G,
HLA-DPA1,
HLA-A,
HLA-F,
SREBF1,
TMED10,
SEC13,
B2M,
HLA-DRB3,
SREBF2,
TMED2,
SEC23A,
HLA-DRB5,
MCFD2,
VTI1B,
SAR1B
|
|
GO:0012510
|
CC
|
trans-Golgi network transport vesicle membrane
|
The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell.
|
RASSF9
|
|
GO:0014069
|
CC
|
postsynaptic density
|
The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms an electron-dense disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases.
|
DLGAP1,
ADAM10,
AXIN1,
LZTS3,
DAB1,
CRYAB,
FYN,
LYN,
FBXO45,
MAPT,
BCR,
DRD2,
IFNGR1,
SYN1,
GAP43,
MT3,
ADORA1,
NSF,
MAP1B,
EPHA4,
NCS1,
DLG4,
ARF1,
CDK5,
FMR1,
SOS1,
GRIN2A,
EPS8,
DLG1,
MAPK8IP2,
MTMR2,
PTCH1,
CACNA1C,
ITPR1,
GRM3,
CNN3,
CPEB4,
NSMF,
ARC,
CAMK2N1,
MAGI2,
HOMER1,
MIB1,
ABI1,
NLGN4X,
NLGN1,
MINK1,
NETO2,
CACNG8,
PDLIM5,
ALS2,
GPER1,
PKP4,
P2RX4,
SIGMAR1,
SYT11,
LIN7B,
GOPC,
HOMER3,
LIN7C,
PSD3,
CRIPT,
IGSF9B,
LZTS1,
PCLO
|
|
GO:0014701
|
CC
|
junctional sarcoplasmic reticulum membrane
|
The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane.
|
AKAP6,
RYR2
|
|
GO:0014704
|
CC
|
intercalated disc
|
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
|
OBSL1,
ATP1B1,
ITGB1,
JUP,
DSP,
GJA1,
DES,
CDH2,
CTNNA1,
GJA5,
GJC1,
ATP1A2,
HAMP,
ANK2,
DSC2,
YWHAH,
TJP1,
ANK3,
DLG1,
AKAP6,
CAMK2D,
DSG2,
KCNJ11,
TMEM65,
FGF13,
PKP2,
RANGRF
|
|
GO:0014731
|
CC
|
spectrin-associated cytoskeleton
|
The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane.
|
SPTBN1,
ANK3,
RHBG
|
|
GO:0015030
|
CC
|
Cajal body
|
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
|
XPO1,
PRPF3,
OIP5,
ZPR1,
SNRPC,
CDK2,
COIL,
FMR1,
NPAT,
SART3,
ICE2,
DDX46,
TRIM22,
PRPF31,
ISG20,
EAF1,
PHAX,
SRRM2
|
|
GO:0015629
|
CC
|
actin cytoskeleton
|
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
HAX1,
WASL,
BIN1,
ABLIM1,
CASK,
PPP1R12A,
FYB,
ARPC2,
ARPC3,
ZNF185,
SLC16A3,
ARHGAP6,
MTSS1,
ACTN4,
PPP1R12B,
FLNB,
STK17B,
SORBS2,
APBB3,
ZBED1,
ALDOA,
APOB,
FGR,
LCP1,
JUP,
EZR,
RAB5A,
FLNA,
CFL1,
CTNNA2,
TARS,
MARCKS,
LSP1,
CTNNA1,
MYH9,
PGM1,
SNCA,
ABL2,
IQGAP1,
CAPZB,
PSMB3,
KNTC1,
CAPZA1,
DAPK1,
SMTN,
DSTN,
ACTR3,
ACTR2,
ACTA2,
ADAM17,
CALD1,
AHNAK,
TWF1,
MYO1E,
IFIT5,
MYO9B,
NFATC2,
IQGAP2,
ZNF268,
POU6F1,
SEPT2,
CNN3,
TAF5,
SEPT7,
DBN1,
FSCN1,
CROCC,
MPRIP,
CENPQ,
ARC,
GAS2L3,
PHC3,
PALLD,
TOPBP1,
CORO2A,
TTC17,
PDLIM5,
PAWR,
PDLIM2,
C9orf72,
FGD4,
FAM129B,
NCAPG,
AIF1L,
NDC1,
TRIOBP,
MYOZ1,
PARD6A,
ANLN,
PDLIM7,
FMN2,
CLIC5,
CTTNBP2NL,
MYOT,
LIMA1,
BAIAP2L1,
CDC42EP3,
INTS6,
RAB22A,
CORO1C,
SYNPO2,
STK38L,
CCDC53,
ORC6,
MAD1L1,
WASF2,
IVNS1ABP
|
|
GO:0015630
|
CC
|
microtubule cytoskeleton
|
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
|
CDC7,
AURKA,
PRC1,
NUAK1,
TACC1,
OFD1,
CCNB2,
MFN2,
TACC2,
CRYAB,
GAPDH,
ESRRA,
GTF2F2,
MAPK3,
MAPK1,
PPP2R1A,
CLIP1,
AKT1,
PRKCI,
ACTR1B,
IQGAP1,
MCM2,
PLK1,
CCNA1,
CDK16,
CENPE,
ID3,
NUCB1,
DST,
CKAP5,
MAP7,
RBM39,
KARS,
MAPRE2,
TAF1A,
SEPT7,
MAP7D1,
MAST2,
PSRC1,
WAPL,
CENPV,
GAS2L3,
CEP57,
RELL1,
KIF18A,
THAP6,
NUDCD2,
CKAP2,
NDRG1,
KIFAP3,
IFT43,
MARK4,
C12orf66,
STRBP,
CHP1,
KIF2C,
FEZ1,
LYST,
KATNB1,
WDR11,
USP44,
ENKD1,
PCIF1,
EML4,
SRA1,
MID1IP1,
RASSF1,
HYPK,
VAPA,
MARK1,
SPATA7,
SLAIN2,
SPAST,
TPX2,
TIMELESS,
KNSTRN,
KIF3A,
F11R,
TACC3
|
|
GO:0015934
|
CC
|
large ribosomal subunit
|
The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).
|
RPL13A,
RBM3,
MRPL30
|
|
GO:0015935
|
CC
|
small ribosomal subunit
|
The smaller of the two subunits of a ribosome.
|
RPS16,
RPS18,
RPS6,
RPS25,
RPS26,
RPS27A,
RPS21,
RACK1
|
|
GO:0016010
|
CC
|
dystrophin-associated glycoprotein complex
|
A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.
|
KRT8,
KRT19,
DMD,
SNTB2,
SNTB1,
DAG1,
SSPN,
SGCB,
SGCD,
FKRP,
MAGEE1
|
|
GO:0016011
|
CC
|
dystroglycan complex
|
A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.
|
DAG1
|
|
GO:0016012
|
CC
|
sarcoglycan complex
|
A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex.
|
SGCB,
SGCD,
SGCZ
|
|
GO:0016013
|
CC
|
syntrophin complex
|
A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase.
|
DMD,
SNTA1
|
|
GO:0016020
|
CC
|
membrane
|
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
ESYT2,
ILVBL,
CNOT1,
MYO1G,
AGPS,
DDX39A,
MYO1C,
LGALS8,
PSMD11,
PSMD12,
HIP1,
CLIC1,
WWP2,
SLC33A1,
IPO5,
PIK3C2A,
GOLIM4,
BTN3A3,
BIN1,
SDCBP,
NOP56,
SCD,
PLPP1,
PLPP3,
AP3D1,
GOSR2,
TOR1A,
ADAM10,
PTGES,
ITGB1BP1,
NDC80,
MGST3,
XPO1,
PIP5K1B,
NPC1,
ARPC3,
PLSCR1,
PGRMC2,
GNPAT,
SLC22A1,
ACOX3,
NPHP1,
ATP6V0E1,
PPM1G,
SLC16A6,
SLC16A3,
ABCC4,
ABCC5,
TLR3,
CYB5B,
DYNC1LI2,
PSMD3,
MAP3K13,
FOXO3,
SPRY2,
CHMP2A,
BUB1,
SGTA,
SLC25A17,
SLC37A4,
CALU,
CD5L,
RAD21,
MED14,
ADCY3,
OPA1,
FADS1,
NRP2,
GPR137B,
PLXNC1,
ACSL4,
MGEA5,
SYNCRIP,
TPST1,
TPST2,
LPXN,
ICMT,
DNAJA2,
NOL3,
SDC3,
COBL,
DNAJB6,
SEMA7A,
HMMR,
MPDU1,
NCOR1,
PEX14,
PRPF40A,
TACC1,
ECI2,
DAB1,
PRKRA,
MED6,
MYCBP2,
OFD1,
PPM1B,
NUP155,
SLC22A3,
PPP1R15A,
AP1G2,
CEACAM4,
TNFSF13,
ARL6IP5,
FLOT1,
RSL1D1,
BEST1,
RECQL4,
SLIT2,
CCNB2,
UBR5,
CSPG5,
SNX4,
KIF4A,
SFT2D2,
PCNT,
CDS2,
TBC1D8,
STAU1,
TSPAN13,
TSPAN12,
FADS2,
RECK,
CLPTM1,
PEX11B,
CYB5A,
LDHA,
CYB5R3,
EGFR,
PGK1,
ADA,
FOS,
NRAS,
KRAS,
LDLR,
HLA-DQA1,
HLA-DQB1,
APOE,
GYPA,
LRG1,
TFRC,
FTL,
ESR1,
ALDOA,
CD74,
KRT1,
GAPDH,
GNAI2,
SLC4A2,
GYPC,
ATP1B1,
ITGB2,
SLC25A5,
SERPINA5,
CFI,
ALPL,
EIF2S1,
ICAM1,
RPLP2,
RPLP0,
ITGB1,
INSR,
CDK1,
ENO1,
GPI,
NPM1,
ITGAV,
HEXA,
LDHB,
ANXA2,
PFN1,
EPRS,
HSP90AA1,
HNRNPC,
IGF1R,
ANXA6,
SLC3A2,
HSP90AB1,
CYC1,
PTPRC,
RPS17,
GNAI3,
ANXA5,
STS,
RPSA,
CD48,
CLTA,
CNP,
HMOX1,
PDGFRB,
HNRNPA1,
LCT,
PARP1,
FURIN,
GLI2,
GAA,
BCL2,
PRKAR1A,
HSPD1,
HSPA5,
SLC2A1,
PYGB,
BCR,
LAMP1,
G6PD,
CYP19A1,
MTHFD1,
IGF2R,
COL6A1,
F5,
ANXA3,
XRCC5,
IFITM1,
LAMP2,
NCAM1,
VCAN,
EEF2,
P4HA1,
GYS1,
PRKAR2A,
HGF,
HCLS1,
HSP90B1,
CCNB1,
SLC2A4,
IL1R1,
HNRNPL,
DARS,
B4GALT1,
EZR,
FOLR1,
NME1,
VEGFA,
RPS2,
ALOX15,
PDGFRA,
ATP2A2,
CD36,
STMN1,
PRKACA,
HLA-G,
CTPS1,
DDX5,
PFKL,
LGALS3,
PSMC3,
RPL35A,
ARF4,
RPL7,
PGAM1,
ATF6,
PAM,
CD58,
FUT1,
ATP2B1,
MSH3,
LMNB1,
ITGAX,
CAST,
FLNA,
NT5E,
FGFR2,
CD9,
COMT,
OSBP,
FUT4,
RPS4Y1,
PAICS,
SCP2,
HNRNPA2B1,
CA4,
PPIB,
CFL1,
ATP2B4,
IL32,
KDELR1,
TNC,
CXCR2,
CD24,
PTAFR,
MCM3,
RPL13,
PTBP1,
PLN,
STOM,
DPP4,
RPL10,
CAD,
CALR,
CANX,
PIK3R1,
ABCD3,
TMOD1,
POLD1,
HSD11B1,
PCSK6,
LTK,
LMOD1,
ERP29,
PRDX6,
RPL12,
PPP2R1A,
PPIF,
NKTR,
HLA-F,
SLC6A1,
SRI,
SERPINB1,
POLR2B,
GNRHR,
CORO1A,
DNAJA1,
HNRNPH1,
YWHAB,
ACSL1,
CDH5,
LSP1,
ABCC1,
MAN1A1,
TTK,
MCM4,
MCM5,
MCM7,
CD68,
CTNNB1,
PHB,
NF2,
KRT9,
MYH9,
SOAT1,
BSG,
PSMC2,
ATP5C1,
RPL4,
DLST,
HPCAL1,
PIGA,
SNCA,
RBMX,
COIL,
GGCX,
DDOST,
FEN1,
IL6ST,
RPL13A,
MLH1,
AQP2,
ACTR1B,
EPS15,
HELZ,
NCAPD3,
LRPPRC,
RPL35,
ECE1,
SLC1A3,
SLC1A2,
SLC1A4,
MATR3,
MSH2,
GRK6,
PSMC4,
MKI67,
RECQL,
RPL27A,
RPL5,
RPL21,
RPL28,
RPS9,
RPS5,
RPS10,
YAP1,
STT3A,
RPL29,
GLIPR1,
PREP,
ARCN1,
LSS,
CD151,
PRRC2A,
PTDSS1,
SLC1A6,
CSNK1A1,
PIK3CG,
CD97,
SLC11A2,
FASN,
PRIM1,
PGF,
VEGFB,
VEGFC,
PSEN1,
RANBP2,
PSEN2,
TSC2,
GDI2,
EMD,
CPT1A,
SLC26A2,
SERPINB9,
LRBA,
PPT1,
RPL14,
ATP1A2,
ANXA11,
FXR1,
FABP6,
SMARCA4,
BCAP31,
HSD17B4,
PSMD7,
CLCN3,
CLCN5,
CLCN7,
PLXNA3,
VAMP7,
NR0B1,
HNRNPM,
KPNA2,
ARHGDIB,
SLC7A2,
KIF11,
COPA,
CTSC,
PTTG1IP,
RARS,
CACNB3,
PRKAG1,
EMP1,
SLC12A2,
CSE1L,
NAP1L1,
HNRNPH2,
BID,
PEX3,
GEMIN4,
NUP107,
CD81,
SEC61G,
MYL6,
ACTB,
EIF4A1,
RPS20,
SNAP25,
CDC42,
RAB5B,
ACTR3,
ACTR2,
ABCE1,
RAP2B,
RPL26,
PSME3,
RPL15,
RPL27,
ATP6V0D1,
HSPE1,
SEC61A1,
B2M,
DAD1,
AP1S1,
RRAS2,
RPS7,
PSMC1,
RPS8,
RPS15A,
RPS16,
YWHAE,
RPS14,
RPS18,
RPS13,
RPS11,
PSMC6,
RPL7A,
RPS6,
HIST1H4A,
RPS26,
GNB1,
GNB2,
RPL30,
RPL31,
RPL10A,
RPL32,
RPL11,
PPIA,
RPS27A,
RAC1,
AP2B1,
VAMP2,
DYNLL1,
GNG5,
EIF5A,
ACTG1,
TPM4,
ACTC1,
EEF1A1,
HIST1H3D,
HBA1,
SIRPA,
GTF2I,
OLR1,
BTN3A2,
JAG1,
PRKDC,
ADAM17,
HLA-DRB3,
RPL24,
RPL19,
GNAS,
VLDLR,
ATP2C1,
MPP1,
SLC25A3,
CDK5,
SORD,
HNRNPU,
SLC7A5,
CENPE,
NRG1,
APBA1,
RPL18A,
NUCB1,
CAV1,
NOTCH2,
SLC18A2,
APLP2,
FMR1,
RPL18,
C1QBP,
KHDRBS1,
BAX,
MCL1,
TNK2,
SLC20A2,
MFGE8,
AHNAK,
APOBR,
HSPA14,
MGAT2,
GALNT2,
GALNT1,
BST2,
ST3GAL1,
ST3GAL4,
AKAP13,
STX4,
CNTN1,
ILF2,
ILF3,
LRMP,
ABR,
TSPAN31,
ECH1,
ARHGAP5,
CALCOCO2,
PSMD2,
DNAJC3,
SELENBP1,
ITGB3BP,
PDE3B,
PLD1,
ILK,
SNTB2,
FKBP5,
MYO9B,
PICALM,
CAMK2D,
DCTN2,
SEMA5A,
SNX1,
CUL3,
RAB32,
CBFB,
CKAP5,
EIF3A,
MLEC,
DCTN1,
DYNC1H1,
EIF2B1,
SELPLG,
CAPRIN1,
ITPR2,
ITPR3,
NBR1,
INPP5A,
ITPR1,
MELK,
GANAB,
CHD4,
KPNB1,
NCAPH,
NCAPD2,
JOSD1,
ARL6IP1,
ACAP2,
KIF14,
ACOX1,
EEA1,
NCF4,
PAFAH1B3,
PCM1,
NOMO1,
PPP2R5A,
NECTIN1,
NONO,
RALBP1,
PCBP1,
RHEB,
DHCR24,
TLR1,
MMD,
ELAVL1,
SLC1A5,
STK11,
ADRM1,
DPYSL2,
IFI16,
UGCG,
CYP51A1,
ATP6V1F,
DUOXA1,
DUOXA2,
ERCC6L,
GRAMD1B,
CCDC88A,
ANO6,
FILIP1L,
CEP55,
PHLDA2,
XKR4,
PIGG,
GNAS,
SPECC1,
UBR4,
ACBD5,
ABHD17B,
CDKAL1,
BSPRY,
ZDHHC20,
GLT8D1,
ATL3,
IQSEC1,
SIGIRR,
ASPHD2,
MFSD5,
LPCAT3,
SLC27A4,
CNKSR3,
SLC27A1,
BRAT1,
CNST,
OGFOD3,
LARP1,
MTHFD1L,
LCLAT1,
DHRS13,
NSMF,
GIGYF2,
HSDL2,
CERS6,
NFXL1,
COLCA1,
MFSD6,
PPP1R3F,
DENND5B,
IKBIP,
LARP4,
DDX46,
RUFY3,
SV2B,
BZW1,
ABHD13,
HS2ST1,
ERMP1,
NUFIP2,
LRP10,
AKNA,
CCDC91,
PNPLA5,
HUWE1,
GALNT7,
SYVN1,
GPAT4,
KTN1,
ALYREF,
LAPTM4B,
CAND1,
SGMS1,
LONP2,
CHSY1,
NCAPG2,
ANKLE2,
ITPRIP,
LRRC8A,
CHERP,
BBS7,
CD302,
DNAJC10,
KIAA2013,
ALDH16A1,
XRN1,
GCNT2,
VPS52,
NUP93,
INTS1,
ASCC3,
PNKD,
CISD2,
NIPA2,
ATAD1,
RNF149,
SERBP1,
ABCF1,
PIK3C3,
PDZD8,
DOCK8,
USP32,
CMAS,
ATL2,
MOSPD2,
PPP1R14C,
RHEBL1,
DNAJB14,
STT3B,
PNPT1,
SPPL3,
SPPL2A,
HM13,
DDX54,
LRRC8C,
NUP210,
GEMIN5,
IPO4,
FRS2,
CYB5D2,
PDCD6IP,
SLC20A1,
SFT2D1,
SNX33,
CHTF18,
DCAKD,
RNF141,
DNAJA4,
SLC44A1,
ATXN2L,
GPR98,
RFFL,
RAPGEF4,
GBF1,
ELMO1,
LPGAT1,
DOCK2,
GCN1,
NUP205,
PIGK,
AKAP1,
SORL1,
RYR2,
DIO2,
DDX17,
APBB2,
RAD50,
GLG1,
KHSRP,
SLCO2A1,
EXT2,
MED12,
PIGT,
NCLN,
ERGIC1,
TMEM106A,
CCDC47,
ADIPOR1,
RERG,
EXOC4,
PNPLA2,
SLC22A18,
APH1A,
ARL8A,
DOCK10,
TUBGCP3,
MUCL1,
CYFIP2,
EDC3,
STAMBPL1,
BICD1,
VMP1,
C16orf58,
PDLIM5,
ERO1A,
PRR11,
TMEM19,
VSIG2,
ZBED3,
ITCH,
LOXL4,
CLPTM1L,
DNAJC1,
SCYL1,
EXOC2,
PCMTD1,
KREMEN1,
MBOAT7,
CCDC115,
ANKRD27,
IPO9,
PGLYRP2,
ALS2,
PANX1,
MED15,
ERGIC2,
TP53RK,
ORAI2,
YME1L1,
MUC4,
SEC62,
CDC5L,
FMO2,
NEU1,
MPHOSPH9,
PIK3R4,
P2RX4,
DNAJC7,
PKMYT1,
KIF2C,
MGLL,
SLC29A1,
CIB1,
RASL11B,
NCAPG,
APOL2,
MYBBP1A,
CCDC77,
SDF4,
PDCD2L,
ORAI3,
ESYT1,
INPP5K,
LRRC1,
NDC1,
TTPAL,
G6PC3,
HTATIP2,
KATNB1,
GNL3,
TMEM106C,
KIFC1,
NUP85,
ELOVL1,
PAPOLG,
BBS2,
C1QTNF3,
NAA15,
PINK1,
FUT8,
HELZ2,
NUF2,
OSBPL8,
WDR11,
EDEM3,
FAM129A,
DERL2,
DDX24,
AP5M1,
DDX47,
EHD4,
SPTBN4,
CXCL16,
PNN,
ACBD3,
PIGU,
WNK1,
DEF6,
PLEKHA4,
ALG9,
ATP13A3,
METTL7A,
REEP1,
PSTPIP2,
LRRC40,
PLEKHA5,
BCL2L12,
PLEKHA2,
RC3H2,
ZFYVE1,
IFT122,
ETNK1,
EML4,
SYTL2,
AGO4,
GOPC,
APMAP,
CD209,
DNAJC4,
ARFGAP3,
PNPLA8,
MMP25,
CD320,
CHST11,
IL1RAP,
MED4,
HPS4,
EIF4ENIF1,
SH2B1,
STRN4,
IL17RB,
SNX15,
AGPAT3,
TOMM22,
KIF15,
PNPLA3,
MDN1,
STAU2,
LMBRD1,
EXOC1,
TMEM30A,
MED17,
FANCI,
ARL8B,
GNL3L,
CLN6,
OCIAD1,
MKS1,
NDE1,
FKBP11,
BET1L,
ELOVL5,
NKIRAS1,
GTSE1,
ERAP1,
FAM120A,
GLTP,
MPP6,
PHRF1,
TENM3,
RRBP1,
CPSF2,
ANKFY1,
DPM3,
ATXN10,
HECA,
DHCR7,
EIF3K,
CKLF,
ADD3,
ABCF2,
SLC23A2,
SEC63,
SLC2A6,
DDX20,
EVL,
LNPEP,
CNOT7,
GGA1,
FBXL2,
MAN1B1,
AMFR,
AGO2,
ITGA11,
BAG5,
KIDINS220,
ASAP1,
CNOT6,
MYO6,
PRPF19,
NENF,
PCDHGC3,
MAGED2,
PLA2G4C,
B9D1,
EXOC7,
PA2G4,
TRPC6,
RUVBL2,
RCE1,
RUVBL1,
ERGIC3,
INVS,
FARSA,
ITM2B,
DRG1,
ATP11B,
DLGAP4,
STK38L,
NISCH,
DIS3,
GSTK1,
DDX52,
LEMD3,
MED16,
GIT1,
DHRS7,
GOLT1B,
RPL36,
HBS1L,
DAAM1,
KIAA0430,
MYO5A,
LOXL2,
HYOU1,
WIPI2,
LAS1L,
PRRC2C,
ATP6V1D,
SRPRB,
ORC6,
IER3IP1,
LYVE1,
FHOD1,
NCOR2,
ALG6,
ARFGEF2,
STK24,
BZW2,
LAMC3,
STON1,
PCLO,
ENPP4
|
|
GO:0016021
|
CC
|
integral component of membrane
|
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
TMEM129,
TMEM120B,
ILVBL,
SERTM1,
FRMD3,
KIAA0922,
TMEM189,
NEMP2,
TLCD2,
TMEM200C,
LRRC37A2,
TMEM212,
KIAA1324L,
C2orf74,
GPR89A,
INAFM1,
C7orf73,
KCNK1,
RNF103,
WRB,
GOLIM4,
BTN3A3,
CHL1,
EBAG9,
SCD,
GOSR2,
ADAM10,
ABCD4,
PTGES,
NRP1,
HS3ST1,
MGST3,
PCDH17,
UQCR11,
CLGN,
NPC1,
SCAMP1,
SCAMP2,
PGRMC2,
KMO,
NDUFA1,
LEPROT,
SURF4,
SPTLC2,
ATP6V0E1,
NCAM2,
STX7,
ABCC4,
CLDN3,
CYB5B,
ADAM12,
B4GALT5,
SPINT2,
AQP9,
MGAM,
CA12,
KDELR3,
ITM2A,
STX6,
SYNGR2,
SYNGR3,
B3GALT2,
SLC37A4,
KLRC4,
BNIP3L,
ADCY3,
SPAG9,
LRRC37A3,
OPA1,
FAM189A1,
FZD6,
FADS1,
NRP2,
MPZL2,
ACSL4,
ADCY9,
TPST1,
B4GALT4,
TSPAN2,
FCMR,
TPST2,
ICMT,
SLC19A2,
TRIM13,
SDC3,
FAM20B,
FZD7,
ATP9A,
MFAP3L,
LRP5,
MPDU1,
ENTPD6,
ENTPD3,
FLNB,
VAMP4,
PEX14,
SEC22B,
CLN5,
STX11,
LRP6,
SLC25A12,
SC5D,
DHRS3,
ARL6IP5,
FLOT1,
SEC14L2,
BEST1,
TMCC1,
TMEM63A,
LRIG2,
ERLIN2,
ABCA8,
CLSTN1,
NDUFB6,
MFN2,
ZFPL1,
NDUFB4,
NDUFB8,
UNC5C,
CSPG5,
LETM1,
SBF1,
VAPB,
BRI3,
CTDNEP1,
ADGRL2,
VNN1,
NPTXR,
SLC2A10,
SFT2D2,
CDS2,
TMEM50A,
CLDN1,
TSPAN12,
CH25H,
TOMM40,
B3GALT4,
CYB5A,
EGFR,
CD4,
GYPA,
ESR1,
HMGCR,
CD74,
ERBB2,
APP,
ALPL,
UGT2B4,
EPHX1,
PSAP,
SLC3A2,
MME,
CYC1,
MET,
CYP3A4,
STS,
PDGFRB,
COX6C,
FURIN,
GPR89B,
SLC35E2,
PET100,
SMIM17,
MGST1,
KIT,
GHR,
SLC2A3,
FGFR1,
FCGR1A,
FCGR2A,
ACE,
IFITM1,
LAMP2,
NCAM1,
HLA-DOB,
HSD3B1,
TYR,
PVR,
B4GALT1,
ACPP,
AREG,
COX7C,
SLC25A16,
PECAM1,
PRLR,
SELE,
IL7R,
XBP1,
SRD5A1,
LAG3,
PAM,
CDH2,
VCAM1,
MAG,
ATP6V1B2,
MAOA,
S1PR1,
FPR1,
SYT1,
KITLG,
ZP3,
FGFR2,
COMT,
FUT4,
ENPP1,
AADAC,
EVI2A,
FSHR,
COX7B,
KDELR1,
FPR2,
PTAFR,
UCP1,
HSD3B2,
MAOB,
DPP4,
IL1R2,
HLA-DMB,
ABCD3,
HSD11B1,
CD40LG,
AVPR2,
SLC6A1,
LRPAP1,
TSPO,
AGTR1,
SRD5A2,
FMO4,
SLC6A6,
FCGR2B,
MC4R,
STX2,
ACSL1,
CDH5,
MAN1A1,
SDC2,
CD68,
BTC,
PTGER4,
G6PC,
SOAT1,
GJC1,
CHRNA7,
BMPR1A,
SREBF1,
HSD17B2,
TGFBR2,
FDFT1,
PIGA,
GGCX,
COL15A1,
MPV17,
DDOST,
IFI27,
DPP6,
NSG1,
ECE1,
SLC1A3,
SLC1A2,
SLC1A4,
PTGER3,
MCAM,
SSR1,
NOTCH1,
IER3,
STT3A,
OR3A3,
SLC6A8,
GLIPR1,
NPBWR1,
ATP5G3,
TM4SF4,
LEPR,
TRAPPC10,
PTDSS1,
MAN2A2,
TMED10,
PSEN1,
RARRES1,
EMD,
LRBA,
RNF144A,
SSR4,
ALDH3A2,
CLCN3,
CLCN6,
CLCN7,
VAMP7,
ADCY7,
NDST1,
SLC25A1,
PTTG1IP,
PLA2G16,
GAS1,
EMP1,
EMP2,
EMP3,
MFAP3,
CDH6,
CDH11,
CDH12,
CDH15,
UCP2,
UCP3,
TPTE,
TMEM50B,
HSD17B7,
EVC,
TCTA,
ANTXR2,
EVA1C,
SEC61G,
PLP1,
ROMO1,
ZP1,
CXCR4,
DAD1,
BLCAP,
SIRPA,
SLC35A2,
BTN3A2,
DLK1,
CRB1,
MXRA7,
VLDLR,
PKD1,
LRP2,
ATP2C1,
REEP5,
IL5RA,
PMP22,
IFITM3,
IL1RL1,
DHODH,
DSC2,
MUC3A,
DST,
PLAUR,
ATP5G2,
APLP2,
PIGF,
MCL1,
IL10RB,
SLC10A7,
C5orf28,
MGAT2,
GALNT1,
FUT2,
TMEM94,
KCNMA1,
ASPH,
STX4,
CDH17,
LRMP,
MALL,
BAMBI,
PTGDR,
STX3,
CLN3,
PDE3B,
ADAM9,
IL18R1,
GPM6B,
SERINC3,
SEMA5A,
PTCH1,
CACNA1C,
CEACAM7,
DAG1,
DSG2,
SCARF1,
MLEC,
SELPLG,
PDE3A,
NFE2L1,
SQLE,
ITPR2,
ITPR1,
TMEM187,
STARD3,
GPNMB,
TMEM132D,
SPCS2,
TRAM2,
ARL6IP1,
SLC39A14,
NOMO1,
NECTIN1,
PTPRK,
ERBB4,
TMED2,
P2RY14,
DHCR24,
RYR3,
NSDHL,
SMAD1,
MSMO1,
VAMP3,
FAM189A2,
EXT1,
OCLN,
PTGIS,
UGCG,
PPP1R3A,
PTPRO,
CYP51A1,
AOC3,
DUOXA1,
DUOXA2,
TMEM132A,
MICB,
LETM2,
NDUFAF6,
CEACAM21,
GRAMD1B,
PIGY,
GNPTAB,
MGAT5B,
TMEM176B,
TIMM50,
CHRFAM7A,
MMEL1,
NKAIN1,
GREB1,
TMEM259,
FNDC3B,
GPAT3,
TMEM35,
ORMDL2,
HSD17B12,
CYBRD1,
SDK2,
TMEM41B,
TMEM97,
TMEM128,
TTMP,
IGSF11,
MEST,
PRRT3,
XKR4,
TECRL,
ALG10B,
RRP12,
COLEC12,
COX20,
MFSD14B,
MANEA,
MUC21,
SLC25A30,
MARCH8,
ABCC10,
SFRP5,
UBR4,
TMEM170B,
GPR158,
ACBD5,
WLS,
MFSD4B,
TMCO4,
ARFGEF3,
TMEM164,
ASPHD1,
GPR157,
MARC1,
C9orf135,
CACHD1,
CDKAL1,
ATRNL1,
SUSD4,
NKAIN2,
PEAR1,
ZDHHC20,
LYSMD4,
CD276,
TBC1D9B,
TMEM198,
HGSNAT,
GLT8D1,
SEL1L3,
ATL3,
MCTP1,
SFRP4,
LAIR1,
SIGIRR,
ASPHD2,
SLC35E4,
OR52E8,
PTCRA,
STYK1,
MFSD5,
RHBDD2,
REEP3,
TCTN3,
DPY19L2,
ERAP2,
LPCAT3,
SLC27A4,
LETMD1,
TMEM53,
SFXN4,
RNASEK,
LRRC8B,
TMEM154,
SLC27A1,
TMEM65,
SLC23A3,
CNST,
OGFOD3,
TXNDC11,
SLC30A9,
ADGRD1,
AGTRAP,
MOXD1,
PARM1,
SHISA2,
TMCO3,
UGT2A3,
LCLAT1,
C6orf89,
TMEM107,
DRAM2,
PLXDC2,
B3GNT9,
PI16,
HRCT1,
SEZ6L2,
TMEM108,
LRRN1,
LRIG3,
CERS6,
GLDN,
AATK,
RNF19B,
NFXL1,
TMEM91,
TMEM182,
DPY19L3,
TMEM136,
COLCA1,
MFSD6,
PPP1R3F,
UBR3,
DENND5B,
LHFPL2,
KIAA1549L,
PTCHD4,
CYP4V2,
MBOAT2,
TMTC3,
SLC25A26,
CHSY3,
IKBIP,
ILDR2,
SMIM5,
PGAP1,
SLC35D2,
SV2A,
SV2B,
ABHD13,
ARMCX6,
FA2H,
LPCAT2,
LINGO2,
CHST15,
HS2ST1,
CHST3,
SLC16A14,
SLC16A9,
SLC36A1,
ERMP1,
DPY19L4,
TMC6,
RNF144B,
GRINA,
MAVS,
CYP2U1,
LRP10,
FAM19A5,
SDK1,
TECPR1,
SLC35E3,
PIGW,
VTCN1,
TMED4,
LHFPL4,
GALNT5,
GALNT7,
SCD5,
GPR126,
GALNT10,
TMEM135,
MTDH,
GPAT4,
KTN1,
SLC51A,
ADIPOR2,
SERINC5,
LRRTM4,
LAPTM4B,
TMEM200A,
P2RY8,
TPRA1,
ANKRD46,
SLC26A11,
OSTM1,
PKHD1L1,
LSR,
CHSY1,
METTL23,
RNF130,
TMEM219,
FRAS1,
COL23A1,
NDUFA11,
ZGRF1,
TMPRSS6,
ZDHHC17,
TMTC1,
RELL1,
VSTM4,
SLITRK4,
TMEM151B,
SLC44A2,
ADGRA3,
SLC30A8,
SGPP2,
CD302,
MCEMP1,
SLC35F2,
TMEM183A,
PLPP6,
PIANP,
TMEFF1,
KIAA2013,
CMTR2,
KIAA0319L,
UNC5B,
ZDHHC14,
DSEL,
CMTM8,
RDH10,
GCNT2,
NLGN4X,
ABCA6,
INTS1,
ARMC10,
ABHD12,
UBE2J2,
TMEM86A,
TMEM256,
MUC15,
GALNT15,
TMEM132C,
SFRP1,
GALNT4,
TOMM5,
TMEM151A,
SLC44A3,
CERS5,
TMEM57,
CISD2,
DRAM1,
SLC15A4,
RNF182,
TMEM251,
TMCO5A,
PQLC3,
EMC1,
C4orf32,
CYB561D1,
NIPA2,
DCBLD1,
CNEP1R1,
POMGNT2,
SLC43A3,
TMEM178A,
TMEM87A,
SLC38A9,
UXS1,
RNF149,
KCT2,
NETO2,
CHST4,
DAGLB,
APCDD1L,
SLC44A5,
BVES,
TRPV1,
TMEM185A,
B3GNT7,
SPTSSB,
DNER,
STXBP6,
OR5A2,
OR5L2,
OR14C36,
ATL2,
LILRB1,
MOSPD2,
MFSD8,
TPCN2,
PCDH19,
PIGX,
DNAJB14,
TMEM167A,
RDH11,
KIAA1524,
STT3B,
MARCH1,
MRAP,
TRPM4,
SLC2A14,
KCNV2,
FAT3,
IGDCC4,
PXYLP1,
RNF128,
GPX8,
NUP210,
PAQR8,
COX7B2,
ATP8B4,
SLC16A10,
SLC25A43,
NAT14,
SFT2D1,
TMEM170A,
SECTM1,
LMBR1,
BTN2A2,
C4orf3,
APH1B,
TMEM40,
GLMP,
KCNE4,
SLC44A1,
ABCA5,
GPR98,
SYNE2,
CLEC4D,
TMEM37,
BRI3BP,
CNTNAP5,
TMEM158,
AQP3,
SEC14L1,
PIEZO1,
CPT1B,
PIGC,
SUSD6,
SLC9A6,
LPGAT1,
SGCD,
FCGR1B,
AKAP1,
DIO2,
PCSK5,
GHSR,
GLG1,
CDS1,
SLC5A5,
ATP6V0A1,
EXT2,
MR1,
SCAMP4,
KISS1R,
MAL2,
YIPF5,
TMEM203,
NCLN,
PMEPA1,
TMBIM1,
ERGIC1,
TMEM106A,
FAM162A,
CCDC47,
ADIPOR1,
MARVELD3,
PNPLA2,
CREB3L1,
SLC22A18,
MIEF2,
RHBDF1,
GPR146,
GRAMD1A,
TLCD1,
SLC25A36,
PLEKHB2,
DNAJC19,
TMCO6,
SMIM19,
OMA1,
YIPF6,
RNFT2,
C11orf24,
DISP1,
SLC47A1,
GALNT14,
PGAP3,
MRAP2,
VMP1,
TMEM261,
FAM163A,
C16orf58,
TCTN2,
SLC41A3,
SLC25A44,
COQ2,
TMEM80,
TMEM19,
TMEM176A,
COX14,
SEC22A,
TXNDC15,
CYYR1,
LRIG1,
ST6GAL2,
MS4A4A,
SLC41A2,
FAR2,
SLC35E1,
CLPTM1L,
DNAJC1,
SMIM8,
MEGF10,
FAM210B,
FCRL1,
SGCZ,
APOLD1,
CARD19,
RMDN2,
MFSD14A,
TMEM68,
HS6ST2,
ROBO3,
KREMEN1,
CMTM3,
MBOAT7,
PTCHD1,
SLC46A1,
CASD1,
DGAT2,
NOX5,
ERMAP,
CSMD1,
SMIM14,
TRPM7,
OR2A5,
PANX2,
PANX1,
SIGLEC11,
ERGIC2,
PCNX1,
LMF1,
MYADM,
SERINC2,
TMEM209,
ORAI2,
YME1L1,
SEC62,
FMO2,
SDHC,
SMAD5,
SIGMAR1,
MGST2,
PRRT1,
PKP2,
VKORC1,
FAM173A,
TMEM47,
HEPH,
TM2D3,
ORAI3,
AIFM2,
SLC35A5,
HERPUD2,
MARVELD1,
NDFIP1,
UPK3B,
TMEM121,
NDC1,
TMEM243,
ABHD6,
SLC25A23,
FICD,
ST6GALNAC5,
ALG8,
TIMM21,
SMIM2,
TMEM106C,
C1orf43,
SFXN3,
SPATA9,
TAPBPL,
JAM3,
TRPM6,
TMEM120A,
CLEC7A,
TMEM59,
EBPL,
SLC46A2,
MS4A8,
SEC11C,
FUT8,
B3GNT5,
PCDH11Y,
OSBPL8,
WDR11,
SLC25A39,
GPR63,
TM6SF1,
CD244,
SIGLEC1,
EPT1,
LNP,
CHST5,
CCDC90B,
MS4A7,
CHST6,
ADAM19,
TMEM168,
LMAN2L,
XYLT2,
CYSTM1,
TMX4,
SLC25A18,
OPN3,
OR51E2,
CXCL16,
SLC26A1,
SEMA6A,
HSD3B7,
SLC38A1,
TMEM60,
TMEM133,
TTYH1,
TMEM245,
GHITM,
ACBD3,
MUC13,
SEMA4A,
MFSD1,
FZD8,
CLSTN2,
ST6GALNAC4,
FNDC4,
ZDHHC6,
ALG9,
CWH43,
LRRC19,
TMEM185B,
C10orf54,
C1orf115,
TMEM206,
DNAJC18,
CNNM2,
REEP1,
RNF121,
SFXN1,
CHODL,
SEC61A2,
FKRP,
CERS4,
ADGRL3,
TRPV4,
VEZT,
SLC38A10,
POPDC2,
POPDC3,
TMEM165,
SLC25A19,
PCDH9,
GBA2,
ANKH,
ROBO2,
PCDH18,
GPAM,
CD248,
MRS2,
APMAP,
CD209,
DNAJC4,
SLC40A1,
PNPLA8,
TNFRSF12A,
TREM1,
MMP25,
SPAG4,
CD320,
CHST11,
NOX4,
TMEM138,
TIMMDC1,
C14orf132,
CD93,
ATP13A2,
SLC35C2,
NPDC1,
CD163L1,
DLL4,
DUOX2,
DUOX1,
OSTC,
PLSCR4,
SMCO4,
SERINC1,
AGPAT4,
AGPAT3,
RPRM,
GPR27,
TNFRSF19,
TOMM22,
CHST7,
TM7SF3,
PNPLA3,
SLC35D1,
GINM1,
TMEM106B,
LMBRD1,
TMEM140,
RNF19A,
TMEM39A,
NDFIP2,
TMEM30A,
ATAD3A,
TMEM38B,
AIG1,
TMEM51,
TMEM45A,
CLN6,
NDUFB11,
SYBU,
SMPD4,
ZDHHC7,
PAQR5,
CLDND1,
B3GNT2,
FKBP11,
BET1L,
CELSR3,
SLC25A37,
ERAP1,
CISD1,
GDE1,
GPRC5B,
CRIM1,
JKAMP,
CCDC167,
EMC3,
NDUFA13,
VAPA,
TMEM14C,
TMEM9,
SLAMF8,
STIM2,
ARMCX1,
TMEM181,
PCDH10,
STOML1,
PEMT,
SPAST,
CKLF,
SEL1L,
SLC25A10,
B4GALT6,
SLC9A2,
VTI1B,
PLEKHB1,
SLC23A2,
SEC63,
TMEFF2,
GGT7,
GPR160,
CDH22,
CRLS1,
ENPP5,
MOSPD1,
LAMP5,
NAGPA,
ADAM21,
MAN1B1,
C14orf1,
ACSL6,
AMFR,
DSE,
TAOK2,
CCPG1,
KIDINS220,
HEG1,
RNF150,
FZD4,
MGAT4A,
BOK,
SLC45A2,
PCDHGC3,
PCDHA12,
SLC6A14,
SSR3,
CYP8B1,
FLVCR2,
IGSF9B,
SLC7A11,
THSD7A,
MGAT4B,
ERVW-1,
LAMP3,
RNF24,
HIGD1A,
ST3GAL6,
TNFSF13B,
VSIG4,
ERGIC3,
WDR83OS,
SLC35A3,
MYRF,
ATP11B,
DNAJC16,
STXBP5L,
SLC27A6,
LEMD3,
ZDHHC9,
TMED5,
GOLT1B,
TMED3,
CHST2,
SAMM50,
PCDHB9,
PCDHB3,
PCDHB14,
PCDHA9,
PCDHA13,
HILPDA,
SRPRB,
DNAJC15,
SLC25A15,
F11R,
ADGRG1,
ALG6,
LHFP,
POMT1,
TMEM14A,
CEPT1,
SLC30A1,
COX11,
ENPP4
|
|
GO:0016023
|
CC
|
cytoplasmic, membrane-bounded vesicle
|
A membrane-bounded vesicle found in the cytoplasm of the cell.
|
MYO1C,
HAX1,
KCNK1,
WASL,
AXIN1,
SOCS1,
AP2A2,
NGF,
TFRC,
TF,
ANG,
CLTA,
PDGFRB,
FGFR1,
C5AR1,
FGFR2,
BDNF,
PRDX6,
OPRL1,
PLA2G4A,
ARHGDIB,
AGFG1,
IST1,
CXCR4,
DST,
KCNA1,
HYAL2,
MALL,
HERC3,
EBP,
PKN1,
CCDC88A,
TMEM35,
FNBP1L,
WLS,
CHIC1,
TMEM198,
SLC39A4,
ARHGAP30,
SLC30A8,
ARL14,
COMMD1,
ARRDC4,
RIN3,
PIFO,
PHLDA1,
SNX33,
USP6NL,
HPS1,
ARHGEF2,
PIGT,
SGK3,
OPTN,
STARD4,
NRBF2,
IFT74,
SNX18,
FNBP1,
NEU1,
SIGMAR1,
MAPKAP1,
ZFYVE21,
ANP32E,
DUSP16,
CD93,
RAB6B,
SYBU,
TAOK2,
MYO6,
SNX6,
SNX9,
ARFGEF2
|
|
GO:0016028
|
CC
|
rhabdomere
|
The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
|
MERTK
|
|
GO:0016035
|
CC
|
zeta DNA polymerase complex
|
A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer.
|
REV3L
|
|
GO:0016222
|
CC
|
procollagen-proline 4-dioxygenase complex
|
A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase.
|
P4HB,
P4HA1
|
|
GO:0016234
|
CC
|
inclusion body
|
A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.
|
HSP90AB1,
HSPA1A,
HSPA1B,
GYS1,
MT3,
SNCA,
PSMC4,
SQSTM1,
HDAC6,
MIOX,
BAG5
|
|
GO:0016235
|
CC
|
aggresome
|
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
|
UBD,
PARK2,
TRIM37,
EEF2,
POLD1,
EPS15,
PSEN1,
SQSTM1,
RAB11B,
DBF4B,
SYNE2,
MVB12A,
SEC62,
HDAC6,
GIT1,
ORC6,
EID1,
CABIN1
|
|
GO:0016272
|
CC
|
prefoldin complex
|
A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
|
PFDN6,
PFDN5,
PFDN4
|
|
GO:0016281
|
CC
|
eukaryotic translation initiation factor 4F complex
|
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
|
EIF4G3,
EIF4E,
EIF4B,
EIF4A1,
EIF4A2
|
|
GO:0016282
|
CC
|
eukaryotic 43S preinitiation complex
|
A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
|
EIF3J,
EIF3B,
EIF3A,
DHX29,
EIF3K
|
|
GO:0016323
|
CC
|
basolateral plasma membrane
|
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
CASK,
SLC22A1,
ABCC4,
AQP9,
CA11,
FLOT1,
BEST1,
MYO1D,
EGFR,
CA2,
PDGFB,
LDLR,
TGFA,
TFRC,
ANXA1,
ERBB2,
SLC4A2,
ATP1B1,
ANXA2,
HSP90AA1,
HSP90AB1,
IL6R,
SLC2A1,
CFTR,
B4GALT1,
EZR,
FOLR1,
HPGD,
CD1D,
DSP,
EPCAM,
CDH2,
ATP2B1,
CHRM3,
C5AR1,
ERBB3,
ENPP1,
ATP2B4,
ITGA3,
CTNNA2,
ADORA1,
STX2,
ABCC1,
CTNNB1,
AQP2,
SLC19A1,
LEPR,
NUMB,
ATP12A,
CXADR,
DLG4,
PKD1,
ANK2,
TEK,
TJP1,
STX4,
CDH17,
ANK3,
DLG1,
SLC14A1,
ADAM9,
DAG1,
MAP7,
ERBB4,
DSTYK,
SLCO4C1,
PIANP,
SLC16A10,
AQP3,
SLC7A6,
MEGF10,
SLC29A1,
HEPH,
CADM1,
RHBG,
CNNM2,
LIN7B,
SLC40A1,
LIN7C,
SLC23A2,
SLC7A8,
NDRG4,
SLC7A7,
SLC4A4
|
|
GO:0016324
|
CC
|
apical plasma membrane
|
The region of the plasma membrane located at the apical end of the cell.
|
KCNK1,
RAB27B,
CLDN4,
MGAM,
ATP8B1,
AHCYL1,
FZD6,
SLC22A5,
SORBS2,
CLDN1,
EGFR,
FN1,
TF,
ANXA1,
ERBB2,
SLC4A2,
ATP1B1,
ADRB2,
HSP90AA1,
SLC3A2,
HSP90AB1,
IL6R,
PDGFRB,
LCT,
SLC2A1,
TDGF1,
CFTR,
EZR,
FOLR1,
MUC1,
EPCAM,
CD36,
GJA1,
IGFBP2,
CDH2,
ATP2B1,
MAL,
ERBB3,
CD9,
SLC2A5,
CA4,
DPP4,
MIP,
OXTR,
RDX,
CHRNA7,
SCNN1A,
AQP2,
SLC19A1,
PRKCI,
EPS15,
NOTCH1,
SLC11A2,
PSEN2,
RAB27A,
SCNN1G,
STC1,
CACNB3,
EMP2,
SLC12A2,
PTEN,
ATP6V0D1,
JAG1,
ADAM17,
SLC7A9,
CRB1,
LRP2,
ANK2,
SLC7A5,
TEK,
PTK2,
TJP1,
PDE4D,
KCNA1,
BST2,
KCNMA1,
HYAL2,
STX3,
PLD1,
TCIRG1,
ITPK1,
SHROOM2,
BMPR2,
DSG2,
CLCA4,
KISS1,
STXBP2,
VAMP3,
SEPT7,
OCLN,
PTPRO,
MFSD4B,
CFAP126,
SLC39A4,
NHS,
CSPG4,
DRAM2,
DSTYK,
MTDH,
AMOTL1,
MUC20,
INADL,
RAPGEF6,
SHROOM3,
KCNE4,
MAL2,
SLC22A18,
SLC46A1,
OSMR,
SLC29A1,
CIB1,
TRPM6,
CDHR2,
ABCG8,
MUC13,
TRPV4,
NOX4,
SLC52A3,
DUOX2,
DUOX1,
TMEM30A,
KL,
SLC23A2,
TNIK,
LZTS1
|
|
GO:0016327
|
CC
|
apicolateral plasma membrane
|
The apical end of the lateral plasma membrane of epithelial cells.
|
CLDN4,
CLDN3,
FZD6,
JUP,
CXADR,
TJP1,
OCLN
|
|
GO:0016328
|
CC
|
lateral plasma membrane
|
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
|
MYO1C,
CLDN4,
AXIN1,
CLDN3,
CLDN1,
ANXA1,
DMD,
DRD2,
JUP,
EPCAM,
GJA1,
ERBB3,
APC,
CTNNB1,
NSG1,
IQGAP1,
PKD1,
ANK3,
DLG1,
SNTA1,
DSG2,
PTPRO,
IQGAP3,
BVES,
TBCD,
CORO1C
|
|
GO:0016342
|
CC
|
catenin complex
|
Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton.
|
SMAD7,
JUP,
CDH2,
APC,
CTNNA1,
CTNNB1,
NECTIN1
|
|
GO:0016363
|
CC
|
nuclear matrix
|
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
ENC1,
RGS12,
CASK,
TGFB1I1,
JAK2,
PRPF40A,
KIF4A,
YEATS4,
TP53,
KRT8,
SPARC,
POLA1,
ALOX5,
CEBPB,
LMNB1,
SFPQ,
CFL1,
YY1,
CAD,
MATR3,
CENPF,
HNRNPM,
BLM,
ATXN3,
ATXN1,
ATN1,
DCAF7,
SATB1,
PRKCD,
RNASEL,
PPIG,
MORC3,
NONO,
ZNF326,
CENPW,
LRIF1,
NSMF,
MAEA,
SRRM1,
PSPC1,
AHCTF1,
GMCL1,
SRPK1,
UHRF1,
PHB2,
TEP1,
SORBS1,
ZNF350,
SPTBN4,
SMARCAD1,
NUFIP1,
SCAF8,
SMC3,
RUVBL2,
RUVBL1,
NCOR2
|
|
GO:0016442
|
CC
|
RISC complex
|
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
|
EIF4E,
DCP2,
AGO4,
LIMD1,
AGO2
|
|
GO:0016459
|
CC
|
myosin complex
|
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
|
MYO1G,
MYO1D,
MYL4,
MYL6B,
MYL12A,
MYL6,
MYL7,
MYO1E,
MYO9B,
MYO19,
MYO10,
MYO5B,
MYO5A
|
|
GO:0016460
|
CC
|
myosin II complex
|
A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures.
|
MYH9
|
|
GO:0016461
|
CC
|
unconventional myosin complex
|
A portmanteau term for myosins other than myosin II.
|
MYO1C,
MYL6B,
MYL6,
MYO6
|
|
GO:0016469
|
CC
|
proton-transporting two-sector ATPase complex
|
A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.
|
ATP6V1C1,
ATP6V1F
|
|
GO:0016471
|
CC
|
vacuolar proton-transporting V-type ATPase complex
|
A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.
|
ATP6V1G1,
ATP6V1G2,
ATP6V0D1,
TCIRG1,
ATP6V1F,
ATP6V0A1
|
|
GO:0016513
|
CC
|
core-binding factor complex
|
A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit.
|
CBFB
|
|
GO:0016514
|
CC
|
SWI/SNF complex
|
A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components.
|
ARID1A,
ACTL6A,
RB1,
SMARCA2,
SMARCA4,
SMARCD3,
ARID1B,
SMARCC2,
SMARCC1,
SMARCD1
|
|
GO:0016528
|
CC
|
sarcoplasm
|
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
|
FABP3,
FLNC
|
|
GO:0016529
|
CC
|
sarcoplasmic reticulum
|
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
|
HAX1,
NOL3,
THBS1,
ATP2A2,
GSTM2,
SRI,
THBS4,
XDH,
CACNA2D1,
ANK3,
AKAP6,
ITPR3,
ITPR1,
RYR3,
SYNE2,
RYR2,
JSRP1,
RASD1,
POMT1
|
|
GO:0016533
|
CC
|
cyclin-dependent protein kinase 5 holoenzyme complex
|
A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits.
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CDK5
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