GO:0006337

BP

nucleosome disassembly

The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.

ARID1A, HMGA1, SMARCA4, SET, SMARCD3, HIST3H2A, SMARCC2, SMARCC1, SMARCD1, SUPT16H

GO:0006338

BP

chromatin remodeling

Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.

SUPT5H, ARID1A, CHD1, SMARCA5, TADA2A, ACTL6A, MYC, ESR1, RB1, TOP1, SMARCA1, DEK, ATRX, SOX9, SMARCA2, SMARCA4, HDAC4, SATB1, RBBP4, CBX3, HDAC1, MORF4L2, INO80C, SMARCD3, SUPT6H, TADA2B, PBRM1, CHD1L, SMARCC2, HDAC2, KAT2B, SMARCC1, SMARCD1, RSF1, FOXP3, INO80B, ACTR6, SMARCAD1, SUV39H2, CHRAC1, BAZ1A, CHD7, RERE, MORF4L1, NUDT5, PADI4, HDAC5, RUVBL2, RUVBL1

GO:0006342

BP

chromatin silencing

Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.

H2AFY, H2AFZ, HIST1H2AG, H2AFX, HIST1H2AD, MORF4L2, HIST2H2AA3, H2AFV, HIST3H2A, SIRT2, HIST1H2AC, H2AFJ, H2AFY2, MORF4L1, HDAC5

GO:0006344

BP

maintenance of chromatin silencing

The maintenance of chromatin in a transcriptionally silent state such as heterochromatin.

ARID1A, UBE2B, HDAC2

GO:0006346

BP

methylation-dependent chromatin silencing

Repression of transcription by methylation of DNA, leading to the formation of heterochromatin.

MBD3, HDAC1, HELLS

GO:0006348

BP

chromatin silencing at telomere

Repression of transcription of telomeric DNA by altering the structure of chromatin.

SIRT2

GO:0006349

BP

regulation of gene expression by genetic imprinting

Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself.

DIRAS3, IGF2, BRCA1, GSK3B, ARID4B, CTCFL

GO:0006351

BP

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

E2F8, MED19, ZNF320, CNOT1, ZNF233, ZNF785, VGLL3, AHRR, ZNF879, NACA, EYA2, APBB1, HIP1, ARNTL, WASL, FOXN3, SAP18, ZNF593, DDX3X, ARID1A, BHLHE40, CHD1, CHD2, ITGB1BP1, ZNF213, IRF6, RGS12, TFEC, HNRNPDL, ZNF646, ZBTB5, SMAD7, SMAD9, MAPK13, HMGB3, HDAC3, BIRC5, TOX3, FOXP2, PER1, ZSCAN9, ZBTB24, DAPK3, ZNF264, PAX4, MAP3K7, HOXA2, HOXA3, TBX1, CBFA2T2, SMAD6, SNAI2, PARK2, ZNF862, ZEB2, KDM1A, NUPR1, HBP1, CREBL2, LPXN, CTNND1, PQBP1, EDF1, BRD4, TBL1X, ZNF623, CNOT3, SIN3B, ZNF253, ZNF217, ERN1, PSIP1, KHDRBS3, TADA3, MYCBP2, TCEA3, ZNF189, KLF7, SEC14L2, URI1, SUPT7L, ABLIM3, KDM4B, TRIM37, HEXIM1, FSBP, ZNF205, ZBTB7A, YEATS4, EYA4, IL33, CBX7, MBD3, ACTL6A, WHSC1, ESR1, NR3C1, MYCN, ERBB2, PRKCB, RB1, PTMA, ENO1, ZFY, COL4A2, HOXC4, ZNF688, TRAPPC2, AR, TXN, FGFR1, SKI, XRCC5, ETS2, FOSL2, ZNF44, ZNF250, TCF3, GCFC2, ZNF823, ZFX, ZNF12, ZNF14, ZNF17, ZNF19, ZNF20, ZNF182, ZNF22, ZNF23, ZNF24, ZKSCAN1, ZNF25, ZNF43, TAL1, ATF7, ATF6, TFEB, BCL3, MAK, NME2, SFPQ, SP100, NR2F2, NFYB, BRD2, YY1, DNMT1, HMGB2, ARNT, HOXD10, SMARCA1, MAPK1, RBL1, EEF1D, HOXA6, FOXN2, CTNNB1, SOX6, ZNF93, NUP62, ZEB1, BRCA1, ANP32A, PBX2, ID1, BCL6, MNDA, STAT5A, LRPPRC, NR4A2, NKX2-1, ATRX, ID4, RFX2, RFX5, NRIP1, HOXA1, HINT1, FHIT, LHX2, MXI1, ERF, ASCL1, ZNF83, ZNF84, SMARCA2, SMARCA4, AFF3, HDGF, MAP2K6, STAT2, ZNF133, ZNF140, ZNF138, HIRA, ATXN3, ATXN1, ATN1, PRKAA2, MLLT10, FOXG1, HDAC4, CTBP2, PRDM15, SOX8, KLF3, ZNF445, DYNLL1, EEF1A1, IRX3, BTG2, SIM1, SMAD3, FOXK1, ZBED6, ZXDB, ZNF200, PURA, E2F1, INSM1, RELB, DR1, SATB1, EWSR1, BNC1, MEF2A, ID2, SP3, ID3, HHEX, POU3F1, CREM, ZNF85, ZNF117, ZNF92, TLE1, TLE3, MXD1, EGR4, ZNF91, ZBTB16, RING1, PAX8, ZNF33A, EGR3, C1QBP, KHDRBS1, FOXM1, AES, ZNF844, ZNF616, RBBP4, ZNF763, ELP6, ZNF816, MN1, SREBF2, FOXO1, PNRC1, TFCP2, TCF15, ILF2, ILF3, PRDM2, ZBTB17, CHAF1B, KLF10, CBX3, MTA1, ITGB3BP, ZNF211, IKZF1, MAMLD1, MED21, HDAC1, TDG, PWP1, NACA, NCOA4, KLF9, C1D, CUX1, HNRNPD, TFDP1, SIM2, NPAT, HES1, RBM39, MXD4, ZNF268, ZNF273, KANK1, LPIN1, ZNF846, CHD4, POU6F1, ARID5B, DRAP1, ZNF638, MORF4L2, SUZ12, BRD3, TCEAL1, NONO, RNPS1, RBBP5, ERBB4, ZMYND11, NCOA2, JMJD1C, TRIP6, TWIST1, NCOA1, CCDC85B, ADIRF, EZH2, ZNF77, ZNF124, PKN1, PKN2, CRY1, MAPK14, IFI16, ZSCAN26, ZNF423, ZNF630, LRRFIP1, PCGF3, ZNF791, CHD9, ZSCAN23, GON4L, ZNF568, ZNF404, ZFP69, KMT5B, ARID4B, LIN52, EPC2, TAF1B, INO80D, ZNF326, ZNF789, BCORL1, ZNF766, ZNF667, ZNF506, HABP4, SAMD4B, BRMS1L, DNTTIP2, ZBTB41, LRIF1, ZNF684, ZNF648, PHF19, ZNF618, DEPDC1, ZNF658, ATF7IP2, IRAK1BP1, KANK2, SPTY2D1, ZNF776, ZNF57, ZNF518A, ZNF787, JADE1, ADNP2, ZNF280D, JMJD6, GTF2H2C_2, ZNF529, ZNF585A, ZNF449, INO80C, ATAD2, SLC30A9, SMARCD3, CRTC3, ZNF562, ATF7IP, KDM7A, SPOCD1, BNC2, ZNF600, ZNF621, TSHZ1, KCTD1, CENPU, ZNF534, ASXL2, SUPT6H, BZW1, ZNF765, ZNF771, BEND5, ZNF627, CXXC5, ZNF367, ZNF550, MIER3, DENND4A, COMMD6, EMSY, ARHGAP22, IRF2BP2, ZNF467, ZSCAN2, PCGF5, ZBTB33, TADA2B, PBRM1, CASZ1, JAZF1, ZSCAN30, SPATA24, GPBP1, CARM1, COMMD2, ZNF677, KMT5C, ZNF573, ZNF280B, GATAD2A, MINA, CREBRF, AEBP1, FOXP4, MGA, WWC1, CCAR1, TP53INP2, SIRT2, YAF2, ZNF440, TRIM22, HACE1, ZNF101, KMT2E, ZNF654, EID3, ZFP82, CCAR2, ZNF567, ASCC3, PHTF2, ZNF808, ZNF276, ZCCHC9, NKAP, COMMD1, EID2, ZNF655, ZNF283, ZNF513, ZNF615, ZNF709, ZNF557, ZNF565, BANP, ZNF610, ZNF579, ZBTB38, ZNF511, INO80E, ZNF485, ZBTB34, RCBTB1, ZNF248, ZNF548, ZNF555, KMT2C, ZMIZ2, ZNF397, ARID1B, BHLHE22, ZFP28, NCOA7, GABPB2, SMARCC2, ZNF420, OSR1, ZSCAN18, ZNF502, ZNF564, ZNF596, ZNF507, ZNF675, DDX54, RB1CC1, ZNF721, ZNF526, ZNF384, SETD7, GTF3C2, PHF10, PPP1R13L, CHURC1, HDAC7, ZFPM2, ZNF606, PSPC1, BBX, ARNTL2, KAT6B, JDP2, HDAC2, DPF3, PROX1, KAT6A, EZH1, DDX17, SMARCC1, KHSRP, RBPMS, TCEAL3, L3MBTL2, ZNF566, UTP4, TP53INP1, TADA1, ZNF669, ZNF689, ZBTB10, TCEAL4, FAM120B, SGF29, ZNF503, ZNF274, CDCA7L, ZNF486, ZNF764, ZNF419, HES6, ZNF625, AJUBA, ZNF845, PAWR, HIC2, EAF1, ZNF333, ZNF462, L3MBTL3, LCOR, ZBTB45, ZNF521, SCYL1, ZNF512B, PRMT6, ZSCAN31, ZNF75A, ZNF578, ZNF641, ZNF285, ZFP3, TOX2, ZNF317, PPP1R10, PURB, PHF12, ZNF300, CIC, CITED4, TRIB3, CCNL2, ZNF347, ZNF607, ZNF587, ATOH8, ZNF382, SPEN, UHRF1, MYCBP, CDC5L, MPHOSPH8, KLF6, PHB2, SMAD5, LITAF, NPAS2, CITED1, CITED2, HOPX, TCF25, MYBBP1A, ZNF559, ZNF2, WAC, DIDO1, PAGR1, ZNF692, HNRNPUL1, ZNF426, PHF20, CDCA7, SSBP3, NAA15, HDAC8, NFKBIZ, HELZ2, WHSC1L1, TBL1XR1, FOXP3, INO80B, ZNF518B, ZNF436, ZNF407, POLR2J2, SLIRP, PEG3, ZNF350, COMMD4, ZNF700, DNTTIP1, BCL11A, ASCC2, EPC1, TSPYL2, IKZF4, DHX36, HIPK2, PNN, FOXP1, TXNIP, ZNF335, SUV39H2, IKZF5, ZNF552, SUDS3, ZNF430, NOL11, ZNF395, MED20, MEAF6, SAP30L, SP110, RRAGC, ZNF287, GPBP1L1, ZBTB20, HES4, ZNF532, ZNF160, CHD8, TCF7L1, ZNF334, SRA1, HMG20A, MYNN, BRD7, PNRC2, TCF7L2, KMT5A, PRDM10, PRDM6, ZNF331, ZNF71, ZNF302, SLC2A4RG, TSHZ2, BAZ1A, ZNF277, HELLS, BRWD1, ZFP64, TXLNG, ASF1B, MTPAP, THAP1, RLIM, ZNF358, MED9, ARGLU1, SLTM, ING3, ZNF586, BCLAF1, ZNF226, RBAK, PRR13, ZNF224, LMCD1, CCDC59, ZKSCAN7, HMG20B, ZBTB4, ZNF492, CHD7, RCOR3, MYEF2, RERE, NLK, UXT, ASH2L, HDAC6, RNF14, MORF4L1, ZMYM2, KDM5B, LIMD1, TCF20, MLX, SAP30BP, PUF60, ZNF230, BAZ1B, CNOT7, ZMYM5, ZFP69B, ZNF112, ZNF222, ZNF580, CCNL1, GTF3C4, HDAC9, AGO2, ZHX1, ZNF236, MYT1L, MKL2, ZBTB21, ZMIZ1, CNOT6, PADI4, KMT2B, PHTF1, SCML1, TIMELESS, TRIM33, USP22, FOXJ3, PA2G4, HDAC5, SCML2, RUVBL2, CDYL, TCF19, LZTS1, RUVBL1, ASF1A, DRG1, MYRF, KDM2A, ZNF337, TSC22D4, NOC2L, L3MBTL1, ZNF175, TRRAP, ZNF451, LOXL2, HES2, PAXBP1, HEY1, UCHL5, KLF2, NCOR2, EID1, COMMD10, CHCHD2, NCOA3

GO:0006352

BP

DNA-templated transcription, initiation

Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.

SMARCA5, TCF4, HIST1H4A, TAF10, TAF5, TAF12, NAT14, RSF1

GO:0006353

BP

DNA-templated transcription, termination

The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.

POLR2A, SETX, MTERF1, TTF2

GO:0006354

BP

DNA-templated transcription, elongation

The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.

SUPT5H

GO:0006355

BP

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

ZNF320, SBNO1, ZNF233, USP27X, ZNF785, VGLL3, PHF20L1, ZNF879, NACA, PDLIM1, EYA2, APBB1, HIP1, ARNTL, WASL, ELL2, NR5A2, BHLHE40, ZNF213, BACH1, TFEC, HNRNPDL, ZNF646, ZBTB5, MAPK13, HMGB3, ZSCAN9, ZBTB24, DAPK3, ZNF264, HOXA3, ZNF207, SOX15, ZNF862, HBP1, FADS1, PDE8A, PRMT3, LPXN, CTNND1, PQBP1, GAS7, EDF1, MITF, FZD7, ZNF623, TSC22D2, CNOT3, ZNF253, ZNF217, TULP3, ERN1, PSIP1, SUPT3H, SRSF10, KHDRBS3, RPS6KA5, MYCBP2, CAPN15, SUPT7L, KDM4B, FSBP, ZFPL1, ZNF205, ZRANB2, EYA4, APBB3, PTTG1, INS, IGF2, ESR1, NR3C1, TP53, INSR, ZFY, HOXC4, ZNF688, TRAPPC2, ESRRA, BMP2, HCLS1, VAV1, ZNF44, ZNF250, TCF3, GCFC2, ZNF823, ZFX, ZNF14, ZNF17, ZNF19, ZNF20, ZNF182, ZNF22, ZNF23, ZKSCAN1, ZNF25, ZNF43, HMGA1, ATF7, CEBPB, ATF4, TFEB, WT1, BTF3, MAK, CDK11B, NME2, POLR2A, NFYB, CALR, MZF1, EEF1D, PPP2R1A, HOXA6, HIVEP2, PHB, RORA, DDIT3, SOX6, AHR, ACVR1B, TGFBR1, ANP32A, STAT3, MNDA, TMPO, TMPO, LRPPRC, GATA4, ATRX, NOTCH1, ZFP36L2, HOXA1, HINT1, FHIT, MXI1, ZNF83, ZNF84, SMARCA2, AFF3, MAP2K6, GTF2A1, ZNF133, ZNF140, ZNF138, HMGA2, RCAN1, ATXN3, PRKAA2, MAZ, PRDM15, KLF3, NUP107, ZNF445, BTG1, DYNLL1, YBX1, EEF1A1, IRX3, SSBP2, TMF1, SARNP, ZXDB, FOXO4, ZNF200, GTF2B, IRF9, E2F1, EWSR1, POU5F1, BNC1, SP3, CREM, ZNF85, ZNF117, ZNF92, NOTCH2, TLE3, EMX2, PRKCQ, EGR4, MEF2C, ZNF33A, EGR3, SOX4, ZFP36L1, SSRP1, ZNF844, ZNF616, RBBP4, EP300, ZNF816, MN1, PNRC1, EFEMP1, FOXC1, TAF10, PRDM2, CHAF1B, MTA1, ITGB3BP, ZNF211, UBE2V1, NFATC2, ACVR2B, RUNX3, NACA, GTF2H2, NFYC, HNRNPD, E2F2, RBM39, ZNF268, ZNF273, KANK1, ZNF846, POU6F1, ZNF638, NR1D2, NONO, RBBP5, TAF5, TAF11, TEAD2, TAF1C, TAF1A, NCOA2, ZNHIT3, JMJD1C, TRIP6, TSC22D1, EZH2, ZFHX3, ZNF141, ZNF77, ZNF124, PKN2, SNAPC1, HIF1A, ZSCAN26, ZNF630, PCGF3, ZNF791, CHD9, ZSCAN23, ZNF568, ZNF404, ZFP69, KMT5B, TAF1B, INO80D, ZNF789, BCORL1, ZNF766, KRBOX4, ZNF506, HABP4, SAMD4B, DNTTIP2, ZBTB41, LRIF1, ZNF684, ZNF648, PHF19, ZNF618, ATF7IP2, IRAK1BP1, SPTY2D1, ZNF776, ZNF57, ZNF787, RALGAPA1, ADNP2, JMJD6, PTRF, GTF2H2C_2, ZNF529, ZNF585A, NFRKB, ZNF449, ZNF880, INO80C, ZNF562, BNC2, ZNF600, ZNF621, USP34, USP51, CENPU, ZNF534, SUPT6H, BZW1, ZNF765, ZNF771, ZNF627, ZNF720, ZNF550, MIER3, DENND4A, EMSY, ARHGAP22, IRF2BP2, ZNF467, ZSCAN2, PBRM1, CASZ1, ZSCAN30, SPATA24, GPBP1, CARM1, COMMD2, ZNF677, KMT5C, ZNF573, PPARGC1B, ERC1, CREBRF, MGA, CCAR1, ZNF440, TRIM22, HACE1, ZNF101, ZNF654, EID3, ZFP82, ASCC3, PHTF2, ZNF808, ZNF276, ZNF655, ZNF283, ZNF513, ZNF615, ZNF709, ZNF557, ZNF565, ZNF610, ZNF579, ZNF511, INO80E, ZNF485, ZBTB34, RCBTB1, ZNF248, ZNF548, ZNF555, KMT2C, ZNF397, NUP35, ZFP28, ZNF420, ZNF502, ZNF596, ZNF507, DDX54, RB1CC1, ZNF721, ZNF526, ZNF384, PHF10, GATAD1, RNF141, ZNF606, PSPC1, BBX, ARNTL2, KAT6B, AHCTF1, GTF3A, ESR2, DPF3, CREBBP, APBB2, KHSRP, SNAPC3, USP13, RBPMS, L3MBTL2, ZNF566, UTP4, FUBP1, TADA1, ZNF669, ZNF689, ZBTB10, FAM120B, SGF29, NRBF2, ZNF503, ZNF274, CDCA7L, ZNF486, ZNF764, ZNF419, CDKN2AIPNL, HES6, ZNF625, AJUBA, GMCL1, ZNF845, EAF1, ZNF333, L3MBTL3, LCOR, ZBTB45, ZNF521, SCYL1, ZNF512B, ZSCAN31, ZNF75A, ZNF578, ZNF285, ZFP3, TOX2, ZNF317, TEFM, ZNF300, ZNF347, ZNF607, ZNF587, MYCBP, PFDN5, MTERF1, TSC22D3, PITX2, PRMT1, MYBBP1A, ZNF559, ZNF2, ZNF692, HNRNPUL1, ZNF426, PHF20, CDCA7, SALL3, WHSC1L1, FOXP3, INO80B, ZNF436, ZNF407, SLIRP, ZNF350, COMMD4, RNF38, ZNF700, DNTTIP1, ASCC2, TSPYL2, PNN, ZNF335, TAF1D, IKZF5, SOX17, TLE6, ZNF430, ZNF395, LIN28A, MEAF6, SAP30L, SP110, PATZ1, GPBP1L1, HES4, ZNF532, ZNF160, TCF7L1, ZNF334, SRA1, HMG20A, MYNN, PNRC2, PRDM10, ZNF331, ZNF71, ZNF302, SLC2A4RG, TULP4, BAZ1A, ZNF277, GLRX2, ZFP64, TXLNG, ASF1B, THAP1, RLIM, ZNF358, ARGLU1, ING3, ZNF586, CDKN2AIP, ZNF226, RBAK, PRR13, CCDC59, ZKSCAN7, HMG20B, ZNF492, CHD7, ZNFX1, NLK, PPARGC1A, ASH2L, RNF14, LIMD1, TCF20, MLX, AFF4, SAP30BP, PUF60, ZNF230, BAZ1B, ZFP69B, ZNF112, ZNF222, ZNF580, NOCT, ZNF236, TCFL5, MYT1L, ZBTB21, CNOT6, PADI4, PHTF1, SUFU, SCML1, GTF2A1L, PPIE, TTF2, SAMD4A, CDK11A, MAPK8IP1, SCML2, CDYL, LZTS1, RNF6, KDM2A, CARHSP1, ZNF337, ZNF175, TRRAP, CSDC2, UCHL5, LRRFIP2, COMMD10

GO:0006356

BP

regulation of transcription from RNA polymerase I promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter.

UBTF, POLR2K, POLR2L, TFAM

GO:0006357

BP

regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

SAP18, ARID1A, CHD1, CHD2, SOX12, MAFG, TBX1, MED7, FOXO3, RAD21, MED14, SOX15, SMARCA5, TRAK2, KDM1A, NUPR1, MAF, TADA2A, SUPT3H, TADA3, MED6, CREG1, TCEA3, KLF7, CIAO1, URI1, IKBKAP, ZMYM6, ZBED1, ACTL6A, FOS, SOD2, MYCN, PRKCB, INHBA, HMGB1, ANXA4, PRKAR1A, THRA, FOSL1, FOSL2, JUNB, JUND, TAL1, ATF6, PAM, WT1, HNF1A, ATP2B4, NR2F2, PTAFR, BRD2, YY1, UCP1, HMGB2, DEK, AHR, SREBF1, ZEB1, BRCA1, STAT3, BUD31, STAT5A, ID4, RFX2, RFX5, IFNAR2, SMARCA2, SMARCA4, STAT5B, STAT2, CEBPG, SUB1, HIRA, FOXG1, GTF2I, ELF3, SIM1, SMAD3, FOXK1, ZBED6, PURA, PPARD, GLO1, ZNF763, ELP6, TFCP2, TCF15, MAMLD1, MED21, CAMK2D, RUNX3, KLF9, CUX1, RUNX2, CBFB, NFYC, VEZF1, TFDP1, SIM2, ZMYM3, NFE2L1, CHD4, MTF1, BRD3, TCEB1, TEAD4, NEDD8, PKN1, MAPK14, QRICH1, LRRFIP1, ZBED5, ARID4B, EPC2, ZNF667, ZNF518A, BRWD3, SMARCD3, TSHZ1, EPM2AIP1, ZNF367, TADA2B, FOXP4, BBS7, ZBED8, LCORL, KIAA1958, JMY, BHLHE22, SMARCC2, ZSCAN18, ARNTL2, SMARCC1, TCEAL3, ELP4, TCEAL4, ZBED6CL, ZNF274, SMARCD1, MED30, ZNF641, CITED4, MED15, TCF12, CDC5L, TEAD3, PITX2, LITAF, CITED1, HOPX, HTATIP2, NFKBIZ, ZNF518B, CTDSP1, NUCKS1, BLZF1, FOXP1, ZNF395, MED20, ELP3, TCF7L1, ENY2, BRD7, MED4, TCF7L2, TSHZ2, BRWD1, MED17, MED9, SLTM, RNF14, ZMYM2, ZMYM5, ELF5, MAFF, TRAK1, FOXJ3, TCF19, RUVBL1, MED16, NFE2L3, MAFB, HCFC2

GO:0006359

BP

regulation of transcription from RNA polymerase III promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter.

POLR3G, BRCA1, ZNF345, POLR3GL, POLR3C, POLR3F

GO:0006360

BP

transcription from RNA polymerase I promoter

The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.

POLR1C, UBTF, GTF2H1, TAF1C, TAF1A

GO:0006361

BP

transcription initiation from RNA polymerase I promoter

Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.

POLR1C, CD3EAP, POLR1A, UBTF, ERCC2, POLR2E, MAPK3, GTF2H1, CDK7, POLR2K, POLR2L, GTF2H2, TAF1C, TAF1A, TAF1B, PTRF, GTF2H4, POLR1E, TAF1D, RRN3, ZNRD1, POLR1D

GO:0006362

BP

transcription elongation from RNA polymerase I promoter

The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.

POLR1C, CD3EAP, POLR1A, UBTF, ERCC2, POLR2E, GTF2H1, CDK7, POLR2K, POLR2L, GTF2H2, TAF1C, TAF1A, TAF1B, GTF2H4, POLR1E, TAF1D, ZNRD1, POLR1D

GO:0006363

BP

termination of RNA polymerase I transcription

The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit.

POLR1C, CD3EAP, POLR1A, UBTF, ERCC2, POLR2E, GTF2H1, CDK7, POLR2K, POLR2L, GTF2H2, TAF1C, TAF1A, TAF1B, PTRF, GTF2H4, POLR1E, TAF1D, ZNRD1, POLR1D

GO:0006364

BP

rRNA processing

Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

NOP56, RIOK3, DKC1, NPM3, UTP20, RPP40, POP4, RPLP1, RPLP2, RPLP0, RPS17, RPSA, RPS2, RPL35A, RPL7, RPL17, RPS4Y1, RPL13, RPL10, RPL12, RPL22, RPL4, RPL13A, SKIV2L2, RPS27, RPL35, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, RPL29, CSNK1D, RPL34, CSNK1E, RPL14, SNU13, GEMIN4, YBEY, RPS20, RPS3A, RPL26, RPL15, RPL27, RPL37A, RPL37, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, RPL7A, RPL23A, RPS6, RPS25, RPS26, RPL30, RPL31, RPL10A, RPL32, RPL11, RPL41, RPS27A, UBA52, RPL38, RPS21, RPP30, RPL24, RPL36A, RPL19, RPL18A, RNASEL, EXOSC9, RPL18, TBL3, EXOSC2, C1D, BOP1, RRP1B, EXOSC7, TSR1, EXOSC6, RPS27L, NOL8, DHX37, PAPD5, WDR36, UTP15, EMG1, UTP4, ISG20, EXOSC8, DDX27, NAF1, EBNA1BP2, RPP25, WDR12, DDX47, SENP3, NOL11, EXOSC4, EXOSC3, MDN1, DCAF13, CHD7, MRTO4, NOB1, WDR3, PA2G4, DIS3, RCL1, DDX52, FCF1, RRP7A, SBDS, RPL36, LAS1L, UTP18, DDX49

GO:0006366

BP

transcription from RNA polymerase II promoter

The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

SUPT5H, WWP2, MEIS1, NFIB, BACH1, PLSCR1, SOX12, POLR2D, MAFG, TGFB1I1, KLF4, FOXO3, TCF21, RAD21, CCNT1, CCNT2, MITF, NCOR1, MAF, TADA2A, SUPT3H, NFAT5, NFATC1, PTTG1, FOS, MYC, ESR1, NR3C1, TP53, JUN, NFIC, HOXB5, PARP1, GLI2, GLI3, MYBL1, MYBL2, THRA, IRF1, EGR2, GTF2F2, FOSL1, HIVEP1, CREB1, HMGA1, JUNB, JUND, CEBPB, XBP1, ERCC2, EGR1, ATF1, ATF3, ATF4, POLR2E, ELK1, WT1, NFKB1, BTF3, HNF1A, POLR2A, MZF1, KDM5A, POLR2B, HOXA10, HIVEP2, OTX2, GTF2H1, GTF2F1, DEK, AHR, POLR2I, RBMX, PBX1, STAT3, ETV5, ELK3, GATA4, SOX9, CEBPD, MEOX1, ETV1, CDK7, STAT5B, POLR2J, GTF2A1, GTF2A2, ZNF136, HMGA2, FOSB, CEBPG, POLR2K, SUB1, DLX5, FOXL2, LMO4, POLR2G, POLR2L, YBX1, GTF2I, ELF3, TMF1, FOXO4, TFAM, GTF2B, IRF9, RUNX1, POU5F1, MEF2A, CREB5, CEBPZ, RELA, REL, MEF2C, GABPA, PAX8, SOX4, DLX2, SSRP1, NCBP1, EP300, FOXC1, TAF10, TARDBP, NMI, NFATC2, SMAD4, RUNX3, BMPR2, GTF2H2, RUNX2, CBFB, NFYC, VEZF1, NFE2L1, ZNF345, MEF2D, MTF1, NFATC4, TCEB1, TCEB2, TAF5, TAF11, TAF1C, TAF1A, TRIP11, TRIP13, TSC22D1, SMAD2, SMAD1, USF2, ZFHX3, ZIC1, ZNF141, TAF12, HLF, NFIL3, HIF1A, HIVEP3, PLAG1, NFRKB, NFXL1, AKNA, LCORL, GLIS3, CTCFL, CSRNP3, GTF2H4, GATA6, SNAPC3, FUBP1, CREB3L1, CSRNP1, TCF12, MNT, MEIS3, PITX2, EPAS1, ARID3A, SALL3, BACH2, POLR2J2, CSRNP2, NUCKS1, MED20, EBF2, PATZ1, TAF9B, MED4, HEYL, ASH1L, EHF, GRHL1, PHRF1, ASH2L, AFF4, TRPS1, ZNF639, KLF15, NOCT, ELF5, TCFL5, MAFF, PLAGL1, GTF2A1L, ZNF148, HIF3A, MED16, KLF13, NFE2L3, SUPT16H, MAFB, CAMTA1

GO:0006367

BP

transcription initiation from RNA polymerase II promoter

Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.

NR5A2, POLR2D, MED7, MED14, MED6, ESR1, NR3C1, PGR, AR, NR2F1, THRA, VDR, ESRRA, GTF2F2, TCF4, ERCC2, POLR2E, NR1D1, NR4A1, POLR2A, RXRB, CTGF, POLR2B, GTF2H1, GTF2F1, RORA, POLR2I, PPARG, NR4A2, NOTCH1, YAP1, CDK8, CDK7, NR0B1, POLR2J, GTF2A1, GTF2A2, POLR2K, NR1H2, MAZ, POLR2G, POLR2L, GTF2I, GTF2B, PPARD, NOTCH2, PPARA, TAF10, NR1H3, TRIM28, GTF2H2, E2F2, NR1D2, NR0B2, TAF5, TAF11, TEAD4, TEAD2, TAF12, MAML2, NR4A3, ESR2, GTF2H4, CREBBP, KAT2B, MED12, NRBF2, MED30, MAML3, NR1H4, MED15, TEAD3, MED20, TAF9B, MED4, MED17, PPARGC1A, GTF2A1L, THRAP3, MED16

GO:0006368

BP

transcription elongation from RNA polymerase II promoter

The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

SUPT5H, ELL2, POLR2D, CCNT1, CCNT2, IKBKAP, GTF2F2, ERCC2, POLR2E, POLR2A, POLR2B, GTF2H1, GTF2F1, POLR2I, CDK7, POLR2J, GTF2A1, GTF2A2, POLR2K, ELOF1, POLR2G, POLR2L, GTF2B, SSRP1, NCBP1, TAF10, GTF2H2, TCEB1, TCEB2, TAF5, TAF11, ADRM1, TAF12, THOC7, RTF1, GTF2H4, ELP4, ELP3, TAF9B, ENY2, SUPT16H

GO:0006369

BP

termination of RNA polymerase II transcription

The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.

DDX39A, NUDT21, ZC3H11A, SNRPB, PAPOLA, MAZ, SNRPF, SNRPD3, SARNP, SRSF2, SRSF11, SRSF1, NCBP1, CPSF1, CSTF3, SRSF9, SRSF5, SRSF6, SLBP, RNPS1, THOC7, FIP1L1, SETX, PABPN1, ALYREF, SRRM1, THOC2, THOC3, POLDIP3, SSU72, CPSF2, TTF2, RBM8A

GO:0006370

BP

7-methylguanosine mRNA capping

Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.

SUPT5H, POLR2D, GTF2F2, ERCC2, POLR2E, POLR2A, POLR2B, GTF2H1, GTF2F1, POLR2I, CDK7, POLR2J, POLR2K, POLR2G, POLR2L, NCBP1, GTF2H2, NCBP3, CMTR2, GTF2H4

GO:0006376

BP

mRNA splice site selection

Selection of a splice site by components of the assembling spliceosome.

NOL3, SRSF10, LUC7L3, SRSF1, SRSF9, SRSF5, SRSF6, SETX, YTHDC1, LUC7L, PTBP2, LUC7L2

GO:0006378

BP

mRNA polyadenylation

The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.

NUDT21, AHCYL1, APP, PAPOLA, CPSF1, GRSF1, CSTF3, PABPC1L, ZC3H3, SYMPK, PAPOLG, SSU72, MTPAP, CPSF2

GO:0006379

BP

mRNA cleavage

Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.

ERN1, POP4, RNASE4, CPSF1, CSTF3, CPSF2

GO:0006382

BP

adenosine to inosine editing

The conversion of an adenosine residue to inosine in an RNA molecule by deamination.

ADARB1, NUDT16

GO:0006383

BP

transcription from RNA polymerase III promoter

The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.

POLR1C, CRCP, TROVE2, POLR2E, POLR2K, POLR2L, ZNF345, GTF3C2, GTF3A, SNAPC3, POLR3C, POLR3F, POLR3B, GTF3C4, POLR1D, POLR3K, IVNS1ABP

GO:0006384

BP

transcription initiation from RNA polymerase III promoter

Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.

POLR3G, CRCP, POLR3GL, GTF3C4

GO:0006386

BP

termination of RNA polymerase III transcription

The process in which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues.

POLR3K

GO:0006388

BP

tRNA splicing, via endonucleolytic cleavage and ligation

Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.

CPSF1, FAM98B, TRPT1, ZBTB8OS, TSEN15, RTCB

GO:0006390

BP

transcription from mitochondrial promoter

The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.

MRPL12, TFAM, PPARGC1B, TEFM, PEO1

GO:0006391

BP

transcription initiation from mitochondrial promoter

A transcription initiation process that takes place at a promoter on the mitochondrial chromosome, and results in RNA synthesis by a mitochondrial RNA polymerase.

TFAM

GO:0006393

BP

termination of mitochondrial transcription

The process in which the synthesis of an RNA molecule using a mitochondrial DNA template is completed.

MTERF1

GO:0006396

BP

RNA processing

Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

RTCA, U2SURP, ZFC3H1, SYNCRIP, DKC1, DUSP11, CELF2, HNRNPL, RBMS1, HNRNPH3, HNRNPH1, NOVA1, RBM5, ATXN1, RBM6, RBM3, HNRNPU, HNRNPD, RBM39, RBMS2, LARP7, DHX30, SETX, DHX29, PABPN1, TMTC1, CHERP, DHX40, DHX37, AGGF1, TDRD9, DDX54, DDX17, RBPMS, SNRNP40, BICD1, LARP6, HNRNPUL1, RBM4, DHX36, DHX35, YTHDC2, DDX20, NUFIP1, LSM7, CCNL1

GO:0006397

BP

mRNA processing

Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.

SAP18, DHX15, RBFOX2, HNRNPR, PRPF3, NUDT21, ZPR1, KHDRBS3, ZRANB2, CELF2, PTBP3, HNRNPA1, PRKACA, LGALS3, SON, HNRNPA2B1, SFPQ, PTBP1, RBM25, AFF2, LSM3, ADARB1, SRSF2, SRSF11, RNASEL, FMR1, C1QBP, KHDRBS1, SRSF1, SF3A3, TARDBP, SRSF9, SRSF5, RBM39, WTAP, NONO, PAN3, ZNF326, RBM26, MBNL2, ARL6IP4, JMJD6, ALKBH5, PAPD4, SUPT6H, RBBP6, SUGP2, CCAR2, AGGF1, SREK1IP1, PAPD5, TSEN15, SREK1, KHSRP, QKI, SRPK1, SCAF11, PRPF18, RBM4B, RBM4, DDX47, RBM38, MBNL1, MBNL3, RBFOX1, AURKAIP1, CDK12, PHRF1, PPARGC1A, PUF60, NOCT, TTF2, SCAF8, THRAP3, LSM5, CSDC2

GO:0006398

BP

mRNA 3'-end processing by stem-loop binding and cleavage

Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine.

SLBP, CPSF2

GO:0006399

BP

tRNA metabolic process

The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.

DTD2

GO:0006400

BP

tRNA modification

The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

SSB, NSUN2, CDKAL1, TRUB1, TRMT6

GO:0006401

BP

RNA catabolic process

The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

RNASET2, RNASEH2A, RNASE2, SKIV2L2, HNRNPD, EXOSC7, RNASEH2B, SUPV3L1, PNPT1, ISG20

GO:0006402

BP

mRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.

ERN1, DXO, RNH1, ZFP36, ZFP36L2, DCP2, PNPT1, KHSRP, NUDT16, AGO4, DIS3

GO:0006403

BP

RNA localization

A process in which RNA is transported to, or maintained in, a specific location.

YY1

GO:0006404

BP

RNA import into nucleus

The import of RNA from the cytoplasm to the nucleus.

TPR

GO:0006405

BP

RNA export from nucleus

The directed movement of RNA from the nucleus to the cytoplasm.

DDX39A, ZC3H11A, NUP155, EIF4E, HNRNPA1, TPR, NUP62, RANBP1, SARNP, SRSF2, SRSF11, SRSF1, NCBP1, SRSF9, SRSF5, SRSF6, RNPS1, THOC7, ALYREF, SRRM1, THOC2, THOC3, POLDIP3, NUP62CL, NXF1, NXT1, RBM8A

GO:0006406

BP

mRNA export from nucleus

The directed movement of mRNA from the nucleus to the cytoplasm.

DDX39A, NUPL2, ZC3H11A, SRSF10, NUP155, EIF4E, TPR, HNRNPA2B1, NUP62, NUP153, RANBP2, AGFG1, NUP107, SHFM1, EIF5A, RAE1, SARNP, SRSF2, HHEX, SRSF11, SRSF1, NCBP1, CPSF1, NUP160, SRSF9, SRSF5, SRSF6, SLBP, RNPS1, THOC7, ALKBH5, FIP1L1, ALYREF, SRRM1, NUP93, NUP43, NUP37, NUP35, THOC2, NUP210, NUP205, SEH1L, THOC3, SMG1, NUP88, BUD13, NDC1, NUP58, NUP85, POLDIP3, UPF2, CPSF2, NXF1, NXT1, NUP50, SMG5, RBMX2, RBM8A

GO:0006407

BP

rRNA export from nucleus

The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins.

RPSA

GO:0006408

BP

snRNA export from nucleus

The directed movement of snRNA from the nucleus to the cytoplasm.

PHAX

GO:0006409

BP

tRNA export from nucleus

The directed movement of tRNA from the nucleus to the cytoplasm.

NUPL2, NUP155, TPR, NUP62, NUP153, RANBP2, NUP107, RAE1, NUP160, NUP93, NUP43, NUP37, NUP35, NUP210, NUP205, SEH1L, NUP88, NDC1, NUP58, NUP85, NUP50

GO:0006412

BP

translation

The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.

IGF2BP3, MRPS12, SLC25A17, MRPS14, SLC25A12, GATB, SLC25A14, EGFR, SLC25A5, RPLP1, RPLP2, RPLP0, RPS17, RPSA, HARS, SLC25A4, DARS, RPS2, SLC25A16, RPL35A, RPL7, RPL17, RPS4Y1, UCP1, RPL13, TARS, RPL10, RPL12, AKT1, RPL22, RPL4, RPL13A, RPS27, RPL35, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, RPL29, RPL34, DHPS, HARS2, SARS, RPL14, SLC25A1, UCP2, UCP3, RPS20, RPS3A, RPL26, RPL15, RPL27, RPL37A, RPL37, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, RPL7A, RPL23A, RPS6, RPS25, RPS26, RPL30, RPL31, RPL10A, RPL32, RPL11, RPL41, RPS27A, RPL38, RPS21, MRPS5, MRPS36, MRPS21, RPL24, RPL36A, RPL19, SLC25A3, RPL18A, RPL18, EIF4EBP2, GTF2H2, MRPL23, CPEB4, MRPL51, SLC25A30, SLC25A26, RPS27L, CPEB2, MRPL55, MRPL52, MRPL41, GUF1, CPEB3, ABCF1, SLC25A43, GCN1, RPL36AL, SLC25A36, RPL39L, SLC25A44, MRPL34, SLC25A23, MRPL32, MRPL4, MRPL1, MRPL37, SLC25A39, SLC25A18, METTL17, SLC25A19, MRPS18A, SLC25A37, MRPL35, MRPL36, RRBP1, SLC25A10, SLC25A13, AGO2, MRPS2, RPL36, HBS1L, SLC25A15, MRPS18B, MRPL42

GO:0006413

BP

translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.

EIF4G3, EIF4E2, EIF1B, EIF5B, EIF3J, EIF2S1, RPLP1, RPLP2, RPLP0, EIF4E, RPS17, RPSA, RPS2, RPL35A, RPL7, RPL17, RPS4Y1, EIF4B, RPL13, RPL10, RPL12, RPL22, RPL4, RPL13A, EIF2S3, EIF1, RPS27, RPL35, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, EIF1AX, RPL29, RPL34, RPL14, EIF5, EIF3B, EIF6, EIF4A1, RPS20, ABCE1, RPS3A, RPL26, RPL15, RPL27, RPL37A, RPL37, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, RPL7A, RPL23A, RPS6, RPS25, RPS26, RPL30, RPL31, RPL10A, RPL32, RPL11, RPL41, RPS27A, UBA52, RPL38, RPS21, RPL24, RPL36A, RPL19, RPL18A, RPL18, EIF2B5, EIF3A, EIF2B1, EIF4A2, LARP1, DHX29, EIF1AD, MTFMT, PAIP1, EIF2B3, EIF3K, EIF2B4, AGO2, RPL36

GO:0006414

BP

translational elongation

The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.

EEF1E1, RPLP1, RPLP2, EEF2, EEF1B2, EEF1D, TSFM, EEF1A1, EEF1A2, HBS1L

GO:0006415

BP

translational termination

The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).

ABCE1, N6AMT1

GO:0006417

BP

regulation of translation

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.

MIF4GD, FOXO3, CDC123, TYMS, APP, S100A9, EIF4E, AKT1, AKT2, RGS2, MTPN, RPS14, RPL38, SARNP, RBM3, PUM3, PIWIL4, LSM14A, NGDN, GCN1, PTCD3, DNAJC1, RBM4B, LARP6, TACO1, MKNK1, MKNK2, EIF2B4, PA2G4, RBM8A, ZNF706

GO:0006418

BP

tRNA aminoacylation for protein translation

The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis.

EEF1E1, FARS2, EPRS, HARS, DARS, TARS, HARS2, SARS, RARS, YARS, LARS2, KARS, PPA2, FARSA

GO:0006420

BP

arginyl-tRNA aminoacylation

The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

RARS

GO:0006422

BP

aspartyl-tRNA aminoacylation

The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

DARS

GO:0006424

BP

glutamyl-tRNA aminoacylation

The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA.

EPRS, EARS2

GO:0006427

BP

histidyl-tRNA aminoacylation

The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

HARS, HARS2

GO:0006429

BP

leucyl-tRNA aminoacylation

The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

LARS2

GO:0006430

BP

lysyl-tRNA aminoacylation

The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

KARS

GO:0006432

BP

phenylalanyl-tRNA aminoacylation

The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

FARS2, FARSA

GO:0006433

BP

prolyl-tRNA aminoacylation

The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

EPRS, PARS2

GO:0006434

BP

seryl-tRNA aminoacylation

The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

SARS

GO:0006435

BP

threonyl-tRNA aminoacylation

The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

TARS

GO:0006437

BP

tyrosyl-tRNA aminoacylation

The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

YARS

GO:0006438

BP

valyl-tRNA aminoacylation

The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

YARS

GO:0006446

BP

regulation of translational initiation

Any process that modulates the frequency, rate or extent of translational initiation.

CTIF, EIF4G3, EIF1B, EIF5B, EIF3J, HSPB1, EIF4B, EIF1, EIF5, EIF3B, EIF4A1, NCBP1, EIF3A, EIF2B1, EIF4A2, EIF2AK4, EIF3K

GO:0006449

BP

regulation of translational termination

Any process that modulates the frequency, rate or extent of translational termination.

HRSP12

GO:0006450

BP

regulation of translational fidelity

Any process that modulates the ability of the translational apparatus to interpret the genetic code.

GATC, RPS5, LARS2, DTD2

GO:0006452

BP

translational frameshifting

A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon.

EIF5A, EIF5A2

GO:0006457

BP

protein folding

The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

CLGN, PFDN6, PPIH, DNAJB6, MPDU1, RP2, CLPX, BAG2, CRYAB, APCS, GNAI2, HSP90AB1, GNAI3, TXN, PDIA4, PRKCSH, GNB3, TCP1, ATF6, DNAJB2, CALR, CANX, ERP29, PDIA3, PPIF, NKTR, LRPAP1, DNAJA1, CCT6A, PPIC, CCT3, RANBP2, RGS7, CCT8, HSPE1, GNB1, GNB2, PPIA, GNAI1, CCT2, FKBP4, PPID, PPIL2, PDCL, PPIG, FKBP5, NFYC, MLEC, PDIA5, GANAB, PDIA6, CDC37, DNAJC21, TXNDC11, CWC27, QSOX2, ERO1B, PPIL4, NUDCD2, DNAJC19, ERO1A, DNAJC1, PFDN5, TTC1, DNAJC7, TXN2, CCT7, ERP44, TBCD, LMAN2L, TMX4, PDCL3, GRPEL1, DNAJC4, MKKS, PFDN4, SPHK1, DNAJB4, BAG5, PPIE, RUVBL2

GO:0006458

BP

de novo' protein folding

The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure.

HSPD1

GO:0006461

BP

protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a protein complex.

WASL, KPNA3, TSPAN4, CLGN, MDM4, PPIH, NUPR1, LPXN, MITF, PEX14, GMNN, SKAP2, IKBKAP, FGA, CD74, TP53, CDK1, EPRS, LAMC1, SLC2A1, CCNB1, DARS, HMGA1, CAPN3, APC, FAS, MAPK3, PPP2R1A, PPP2R1B, OTX2, CAPG, SOX9, KNTC1, CAPZA1, SH3BGR, VAMP2, DLG4, SLC7A9, MDM2, APBA1, PPID, TRAF1, CHAF1A, CHAF1B, PICALM, HES1, TCEB2, VAMP3, OCLN, HFE, REPS2, DLG5, GEMIN5, PARD3, SLC7A6, CREBBP, KIFAP3, MAGI1, RANBP9, CARD10, SSBP3, NIFK, PARD6B, IL1RAP, MDN1, MPP6, PPARGC1A, SLC7A7, ZNF148

GO:0006463

BP

steroid hormone receptor complex assembly

The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor.

FKBP4

GO:0006464

BP

cellular protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

WWP2, PLOD2, MAN2B1, ICMT, PLAT, CPE, CHRM3, LOX, AKT1, AKT2, USP6, GGCX, UBA7, ABL2, PHKA2, CDC34, SEPHS1, MMP15, RABGGTB, ADPRH, UBE2D3, UBE2M, UBA52, UBE2I, SLC35A1, PRKDC, PLOD1, ST3GAL1, PIGH, STK38, NEDD8, UBE2S, QPCT, ST3GAL2, TTLL9, ERO1B, FBXO22, TTL, ST8SIA4, BAP1, ERO1A, USP25, LCMT1, NAGPA, FBXL2, RIMKLB, PADI4, LIPT1, ST3GAL6, LOXL2, CSNK1G3

GO:0006465

BP

signal peptide processing

The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.

CLN5, F2, BGLAP, FURIN, GAS6, SPCS2, SPPL3, SPPL2A, HM13, PCSK5, SEC11C

GO:0006468

BP

protein phosphorylation

The process of introducing a phosphate group on to a protein.

PIK3CD, PLK4, ADAM10, RIOK3, CASK, AURKA, DCLK1, FYB, SMAD9, BIRC5, IRAK2, MAP3K13, DAPK3, BUB1, NUAK1, CCNT1, BUB1B, CCNT2, JAK2, ROCK2, ULK1, ERN1, PRKRA, RPS6KA5, STK17B, IKBKAP, MAP4K4, LATS1, PDGFB, TGFB1, RAF1, ERBB2, NTRK1, APP, PRKCB, FYN, LYN, FGR, BCR, FGFR1, PSKH1, CDK4, BMP2, CCL2, CREB1, PRKCA, PRKACA, IGFBP3, ERCC2, NPR2, MAK, CDK11B, JAK1, ITPKA, MAPK3, PIK3R1, MAPK1, LTK, CDC25B, AKT1, ADRBK2, BMPR1A, ACVR1B, TGFBR1, TGFBR2, CSK, MAP3K8, PRKCI, PIK3CA, GRK6, SYK, MAPK8, MAPK9, PHKA2, PHKA1, CSNK1A1, CSNK1D, PIK3CG, MAPKAPK2, CDK8, CSNK1E, CLK2, GSK3B, CDK7, IRAK1, NEK2, NEK3, NEK4, JAK3, PLK1, DAPK1, LIMK2, PRKAG1, PRKAA2, SIK1, TGFB2, SRPK2, CCL8, CDK3, CDK6, CDK16, HSF1, GUCY2D, ACVR1, LIPE, PRKCD, RNASEL, DMPK, ST3GAL1, AKAP13, MERTK, ILF3, STK4, PAK2, PTK7, ILK, SQSTM1, PRPF4B, CAMK2D, RUNX3, GTF2H2, CAMK1, MORC3, FASTK, GAS6, PDK1, CDK10, PRKD1, STK38, RPS6KA1, MMD, MYLK, STK11, PKN1, PKN2, PDK4, DGUOK, AAK1, SBK1, PAN3, MLK4, CDC42BPA, MAST2, PNCK, AATK, NEK10, NEK8, CAMK1D, MAP4K3, TEX14, FAM20C, SCYL3, MINK1, STKLD1, PIK3C3, ANKK1, NEK11, NEK9, STK35, NEK7, GSG2, DYRK2, TBRG4, SGK3, ULK4, AURKB, RSRC1, PBK, MARK4, NEK1, ALPK1, PASK, TRIB3, TP53RK, SRPK1, PIK3R4, PKMYT1, MAP3K5, SMAD5, VRK1, MKNK1, CDK19, TRPM6, PINK1, WNK3, PRKD2, SIK2, TAOK3, HIPK2, WNK1, MKNK2, NEK6, LATS2, SNX15, NRBP2, BMP2K, ZAK, PLK2, MARK1, FNIP2, EIF2AK4, NLK, PRKAG3, TNIK, TLK1, CDK11A, AKT3, STK38L, SIK3, MAP4K5, CDC42BPB, IRAK3, STK24, XRCC6BP1

GO:0006469

BP

negative regulation of protein kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.

SOCS2, SOCS3, SOCS6, ITGB1BP1, SOCS1, FLRT2, GADD45B, LRP6, HSPB1, IL6, RB1, DCN, PTPRC, GSTP1, FABP4, BGN, GADD45A, AKT1, SFN, NF2, PPM1F, TSC2, GNAQ, PAK2, DNAJC3, ILK, PPP1R1A, SHB, RGN, PKN1, PODN, CAMK2N1, RTN4RL1, LRRTM4, CRIPAK, DEPTOR, UBASH3B, DUSP19, PPM1E, TRIB2, TRIB3, TRIB1, CHP1, DBNDD2, INPP5K, TAOK3, LRRC19, SMYD3, FLRT3, FLRT1

GO:0006470

BP

protein dephosphorylation

The process of removing one or more phosphoric residues from a protein.

PP2D1, PPP6C, PLPP1, PLPP3, CTDSP2, PPP1R12A, CTDSPL, PPM1G, CDC14B, DUSP11, PPM1B, SBF1, CTDNEP1, PPP1R3D, PTPRC, BCL2, PTPRB, PTPRD, PTPRM, PTPN4, PPP2R1A, PPP1CC, PTPN9, TPTE, PTEN, PPP4C, PPP1CA, PPP1CB, PPP2CB, CYCS, DUSP2, PPP2R3A, PPP3CA, DLG1, MTM1, MTMR2, PPP2R5D, PTPRK, DLGAP5, TAB1, DUSP5, PTPN21, PTPRO, TIMM50, PPM1J, TNS2, PHLPP2, SSH2, PPP1R3B, PPM1K, PPTC7, UBLCP1, DUSP9, CPPED1, DUSP26, CTDSP1, PPA2, DUSP22, PHPT1, MTMR4, CTTNBP2NL, DUSP13, PPM1H, BTRC, PTPN22, DUSP10

GO:0006471

BP

protein ADP-ribosylation

The transfer, from NAD, of ADP-ribose to protein amino acids.

TNKS, PARP1, ARF4, SIRT2, TNKS2, PARP2

GO:0006473

BP

protein acetylation

The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.

NUPR1, EP300, FOXO1, CREBBP, KAT6A, KAT2B

GO:0006474

BP

N-terminal protein amino acid acetylation

The acetylation of the N-terminal amino acid of proteins.

NAT9, NAA15, NAA50

GO:0006475

BP

internal protein amino acid acetylation

The addition of an acetyl group to a non-terminal amino acid in a protein.

PCK1, MDH2, EP300

GO:0006476

BP

protein deacetylation

The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.

HDAC3, HDAC1, SIRT2, HDAC6, HDAC5

GO:0006477

BP

protein sulfation

The addition of a sulfate group as an ester to a protein amino acid.

NDST1, CHST4, CHST5

GO:0006478

BP

peptidyl-tyrosine sulfation

The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine.

TPST1, TPST2

GO:0006479

BP

protein methylation

The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.

SNRPB, GSPT1, PCMT1, SNRPD3, BTG1, BTG2, METTL21A, PCMTD1, PRMT1, LCMT1, N6AMT1

GO:0006481

BP

C-terminal protein methylation

The methylation of the C-terminal amino acid of a protein.

ICMT, LCMT1

GO:0006482

BP

protein demethylation

The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.

KDM1A, PPME1

GO:0006486

BP

protein glycosylation

A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

NPC1, PMM2, B3GALT2, B4GALT4, LARGE, B3GALT4, FUT1, FUT4, DDOST, PSEN1, DAD1, LRP2, GOLGA2, FUT2, TRIP11, EXT1, ALG10B, B3GNT9, GCNT2, ST8SIA4, EXT2, SDF2, B3GNT5, ALG9, B4GALT6, NAGPA

GO:0006487

BP

protein N-linked glycosylation

A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.

B4GALT1, FUT4, DDOST, MGAT2, ST3GAL1, MGAT5B, ALG8, FUT8, TMEM165, MAN1C1, ALG6

GO:0006488

BP

dolichol-linked oligosaccharide biosynthetic process

The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P.

MPDU1, ALG10B, PQLC3, ALG8, ALG9, ALG13, ALG6

GO:0006489

BP

dolichyl diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative.

MVD

GO:0006490

BP

oligosaccharide-lipid intermediate biosynthetic process

The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation.

ALG8, ALG6

GO:0006491

BP

N-glycan processing

The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking.

PRKCSH, MAN1A1, MAN2A2, ENGASE, ST8SIA4, EDEM1, FUT8, EDEM3, MAN1C1, MAN1B1, MGAT4A, MGAT4B

GO:0006493

BP

protein O-linked glycosylation

A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.

OGT, TRAK2, LARGE, VEGFB, ST8SIA6, GALNT2, GALNT1, DAG1, GALNT7, GALNT10, POMGNT2, TRAK1, POMT1

GO:0006497

BP

protein lipidation

The covalent attachment of lipid groups to an amino acid in a protein.

ABCA1, WIPI1, PIK3C3, ATG10, WDR45, WIPI2

GO:0006499

BP

N-terminal protein myristoylation

The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.

PPM1B