GO:0061309

BP

cardiac neural crest cell development involved in outflow tract morphogenesis

The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract.

JAG1, HES1

GO:0061312

BP

BMP signaling pathway involved in heart development

A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time.

BMP4, BMPR1A, ACVR1

GO:0061314

BP

Notch signaling involved in heart development

The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time.

NOTCH1, JAG1, NOTCH2, DLL4, HEY1

GO:0061324

BP

canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation

The canonical Wnt signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells.

CTNNB1

GO:0061325

BP

cell proliferation involved in outflow tract morphogenesis

The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract.

PITX2

GO:0061333

BP

renal tubule morphogenesis

The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.

MTSS1, MEF2C, PKD2

GO:0061337

BP

cardiac conduction

Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.

KCNK1, KCNK3, CACNB3, CACNA2D1, MEF2A, KCNH2, CACNA1C, KCNJ12, TRPM4, CACNG8, CACNG6, SPTBN4, KCNIP2, KCNK6

GO:0061343

BP

cell adhesion involved in heart morphogenesis

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart.

FLRT2

GO:0061347

BP

planar cell polarity pathway involved in outflow tract morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract.

WNT5A

GO:0061348

BP

planar cell polarity pathway involved in ventricular septum morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum.

WNT5A

GO:0061349

BP

planar cell polarity pathway involved in cardiac right atrium morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium.

WNT5A

GO:0061350

BP

planar cell polarity pathway involved in cardiac muscle tissue morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue.

WNT5A

GO:0061351

BP

neural precursor cell proliferation

The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.

EPHB1, MELK, DBN1, ORC3

GO:0061354

BP

planar cell polarity pathway involved in pericardium morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium.

WNT5A

GO:0061355

BP

Wnt protein secretion

The controlled release of a Wnt protein from a cell.

WLS

GO:0061357

BP

positive regulation of Wnt protein secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell.

WLS, VPS35

GO:0061364

BP

apoptotic process involved in luteolysis

The apoptotic process that contributes to luteolysis.

SLIT2, ROBO2

GO:0061368

BP

behavioral response to formalin induced pain

Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus.

NTRK1

GO:0061370

BP

testosterone biosynthetic process

The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5.

HSD17B1, AKR1C3, STAR

GO:0061383

BP

trabecula morphogenesis

The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.

RHOA

GO:0061384

BP

heart trabecula morphogenesis

The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.

S1PR1, NOTCH1, TGFBR3, SOS1

GO:0061386

BP

closure of optic fissure

The closure of the temporary ventral gap in the optic cup that contributes to its shaping.

PHACTR4

GO:0061394

BP

regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance

Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.

ATF3

GO:0061395

BP

positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.

ATF4

GO:0061402

BP

positive regulation of transcription from RNA polymerase II promoter in response to acidic pH

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7.

PCK1

GO:0061418

BP

regulation of transcription from RNA polymerase II promoter in response to hypoxia

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.

BACH1, UBC, VEGFA, EGR1, ARNT, UBE2D3, RBX1, RPS27A, UBA52, EP300, CUL2, TCEB1, TCEB2, HIF1A, CREBBP, EPAS1, EGLN3, HIF3A

GO:0061419

BP

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.

VEGFA, NOTCH1, HIF1A

GO:0061428

BP

negative regulation of transcription from RNA polymerase II promoter in response to hypoxia

Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.

SIRT2, CITED2

GO:0061433

BP

cellular response to caloric restriction

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake.

SIRT2

GO:0061436

BP

establishment of skin barrier

Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.

CLDN4, CLDN1, KRT1, KRT16, SFN, CYP26B1

GO:0061441

BP

renal artery morphogenesis

The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood.

NRP1, PKD2

GO:0061444

BP

endocardial cushion cell development

The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state.

JAG1

GO:0061445

BP

endocardial cushion cell fate commitment

The commitment of a cell to an endocardial cushion cell fate and its capacity to differentiate into an endocardial cushion cell.

ACVR1

GO:0061458

BP

reproductive system development

The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.

NDUFS6, PLEKHA5

GO:0061462

BP

protein localization to lysosome

A process in which a protein is transported to, or maintained in, a location within a lysosome.

CD81, RNF128, SH3BP4

GO:0061469

BP

regulation of type B pancreatic cell proliferation

Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation.

NR1D1, NR4A1, NR4A3, C7orf55, ERRFI1

GO:0061470

BP

T follicular helper cell differentiation

The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell.

GPR183, FOXP1, RC3H2

GO:0061485

BP

memory T cell proliferation

The expansion of a memory T cell population by cell division.

DOCK8

GO:0061502

BP

early endosome to recycling endosome transport

The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes.

MYO1D, CORO1A

GO:0061504

BP

cyclic threonylcarbamoyladenosine biosynthetic process

The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.

UBA5

GO:0061511

BP

centriole elongation

The centrosome organization process by which a centriole increases in length as part of the process of replication.

CENPJ

GO:0061512

BP

protein localization to cilium

A process in which a protein is transported to, or maintained in, a location within a cilium.

RAB11FIP3, ARF4, CSNK1D, BBS1, IFT122, TULP4, WDR35, ATP6V1D

GO:0061518

BP

microglial cell proliferation

The expansion of a microglial cell population by cell division.

IL33, CLU

GO:0061548

BP

ganglion development

The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure.

TULP3

GO:0061549

BP

sympathetic ganglion development

The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.

NRP1, NRP2, CTNNB1, ASCL1, INSM1, SEMA3A

GO:0061550

BP

cranial ganglion development

The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.

CTNNB1

GO:0061551

BP

trigeminal ganglion development

The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.

NRP1, SEMA3A

GO:0061564

BP

axon development

The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation).

TSPAN2, ZPR1, NEFH, GAP43, PLP1

GO:0061572

BP

actin filament bundle organization

A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.

FAM101A, FAM101B

GO:0061577

BP

calcium ion transmembrane transport via high voltage-gated calcium channel

A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel.

CACNB3, CACNA2D1, CACNA1C

GO:0061580

BP

colon epithelial cell migration

The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism.

ARSB

GO:0061582

BP

intestinal epithelial cell migration

The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism.

PTPN11

GO:0061589

BP

calcium activated phosphatidylserine scrambling

The movement of a population of phosphatidylserine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.

ANO6

GO:0061590

BP

calcium activated phosphatidylcholine scrambling

The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.

ANO6

GO:0061591

BP

calcium activated galactosylceramide scrambling

The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.

ANO6

GO:0061614

BP

pri-miRNA transcription from RNA polymerase II promoter

The cellular synthesis of primary microRNA (pri-miRNA) transcripts from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. pri-miRNA transcripts are subsequently processed to produce the ~22nt miRNAs that function in gene regulation.

ETS1, FOSL1

GO:0061621

BP

canonical glycolysis

The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.

PFKFB2, PGK1, ALDOA, GAPDH, ENO1, GPI, ENO2, ALDOC, ENO3, PKM, PFKFB1, PFKL, PGAM1, HK1, TPI1, PFKFB3, PFKFB4

GO:0061624

BP

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate.

ALDH1A1, TKFC

GO:0061626

BP

pharyngeal arch artery morphogenesis

The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery.

BMP4, FOLR1, BMPR1A, TGFB2, BMPR2, HES1

GO:0061635

BP

regulation of protein complex stability

Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly.

SQSTM1, SCOC

GO:0061646

BP

positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization

Any process that activates or increases the frequency, rate or extent of glutamate secretion in response to membrane depolarization, where glutamate acts as a neurotransmitter.

RAB3GAP1

GO:0061669

BP

spontaneous neurotransmitter secretion

Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential.

RIMS2

GO:0061682

BP

seminal vesicle morphogenesis

The process in which the anatomical structures of a seminal vesicle are generated and organized.

ID4

GO:0061684

BP

chaperone-mediated autophagy

The autophagy process which begins when chaperones and co-chaperones recognize a KFERQ-related motif and unfold the substrate protein. The process ends with the catabolism of the protein in the lysosome.

HSP90AA1, LAMP2

GO:0061709

BP

reticulophagy

The autophagic process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.

RB1CC1

GO:0061713

BP

anterior neural tube closure

The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline.

FOLR1

GO:0061723

BP

glycophagy

The autophagic process in which cellular glycogen is delivered to the vacuole and degraded in response to changing cellular conditions.

RB1CC1

GO:0061724

BP

lipophagy

The autophagic process in which lipid droplets are delivered to the vacuole and degraded in response to changing cellular conditions.

RAB7A

GO:0061732

BP

mitochondrial acetyl-CoA biosynthetic process from pyruvate

The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA.

PDHA1, DLD, PDHB

GO:0061734

BP

parkin-mediated mitophagy in response to mitochondrial depolarization

The macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule.

PARK2, MFN2, OPTN

GO:0061738

BP

late endosomal microautophagy

The autophagy process by which cytosolic proteins targeted for degradation are tagged with a chaperone and are directly transferred into and degraded in a late endosomal compartment.

VPS4B

GO:0061743

BP

motor learning

Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience.

DKK1

GO:0065001

BP

specification of axis polarity

The pattern specification process in which the polarity of a body or organ axis is established and maintained.

AHI1

GO:0065002

BP

intracellular protein transmembrane transport

The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.

AKT2, C2CD5

GO:0065004

BP

protein-DNA complex assembly

The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.

SOX12, TCF4

GO:0070050

BP

neuron cellular homeostasis

The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.

PARK2, TYRO3, NELL2

GO:0070054

BP

mRNA splicing, via endonucleolytic cleavage and ligation

Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.

ERN1

GO:0070055

BP

mRNA endonucleolytic cleavage involved in unfolded protein response

The endonucleolytic cleavage of a mRNA containing an HAC1-type intron at the 5' and 3' splice sites. The cleavage step is part of unconventional mRNA splicing, and contributes to the endoplasmic reticulum unfolded protein response.

ERN1

GO:0070059

BP

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.

ERN1, PPP1R15A, AIFM1, BCL2, CEBPB, XBP1, ATF4, DDIT3, CASP4, GSK3B, BAX, PMAIP1, ITPR1, DNAJC10, ERO1A, TRIB3, MAP3K5, CHAC1

GO:0070060

BP

de novo' actin filament nucleation

The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament.

JMY

GO:0070072

BP

vacuolar proton-transporting V-type ATPase complex assembly

The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane.

TCIRG1, ATP6V0A1

GO:0070076

BP

histone lysine demethylation

The modification of a histone by the removal of a methyl group from a lysine residue.

UBE2B

GO:0070078

BP

histone H3-R2 demethylation

The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone.

JMJD6

GO:0070079

BP

histone H4-R3 demethylation

The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone.

JMJD6

GO:0070084

BP

protein initiator methionine removal

The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein.

METAP2

GO:0070085

BP

glycosylation

The covalent attachment and further modification of carbohydrate residues to a substrate molecule.

CLN5, COG6

GO:0070086

BP

ubiquitin-dependent endocytosis

Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded.

NEURL1B

GO:0070091

BP

glucagon secretion

The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).

IL6

GO:0070092

BP

regulation of glucagon secretion

Any process that modulates the frequency, rate or extent of the regulated release of glucagon.

PASK

GO:0070093

BP

negative regulation of glucagon secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.

LEP, CARTPT

GO:0070096

BP

mitochondrial outer membrane translocase complex assembly

The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex.

TOMM20

GO:0070098

BP

chemokine-mediated signaling pathway

A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

PPBP, PF4, CXCL1, CXCL8, CCL3, CCL4, CCL2, CCL5, CXCL2, CXCR2, CXCL5, CXCL12, CXCR4, CCL20, CCL8, CXCL6, ACKR4

GO:0070100

BP

negative regulation of chemokine-mediated signaling pathway

Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor.

SLIT2, CCL5

GO:0070101

BP

positive regulation of chemokine-mediated signaling pathway

Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor.

EDN1, HIF1A

GO:0070102

BP

interleukin-6-mediated signaling pathway

A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IL6, IL6R, IL6ST, STAT3, GAB1, SMAD4

GO:0070104

BP

negative regulation of interleukin-6-mediated signaling pathway

Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor.

PTPN2

GO:0070106

BP

interleukin-27-mediated signaling pathway

A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IL6ST

GO:0070120

BP

ciliary neurotrophic factor-mediated signaling pathway

A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IL6R, IL6ST, LIFR

GO:0070121

BP

Kupffer's vesicle development

The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.

AHI1

GO:0070124

BP

mitochondrial translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.

MTIF3