GO:0060437

BP

lung growth

The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.

SPRY2

GO:0060438

BP

trachea development

The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.

BMP4

GO:0060440

BP

trachea formation

The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches.

BMP4, MAPK3, MAPK1, CTNNB1, TGFBR2, MAP2K1

GO:0060441

BP

epithelial tube branching involved in lung morphogenesis

The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.

KRAS, BMP4, CTNNB1, NKX2-1, SOX9, DAG1, DLG5, HHIP, ESRP2, CTSZ

GO:0060442

BP

branching involved in prostate gland morphogenesis

The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.

BMP4, FGFR2, FEM1B

GO:0060443

BP

mammary gland morphogenesis

The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.

TGFBR2

GO:0060444

BP

branching involved in mammary gland duct morphogenesis

The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.

LRP5, DDR1, KDM5B, BTRC

GO:0060445

BP

branching involved in salivary gland morphogenesis

The process in which the branching structure of the salivary gland is generated and organized.

IL6, FGFR1, FGF7, FGFR2, TGM2, DAG1, ESRP2

GO:0060447

BP

bud outgrowth involved in lung branching

The process in which a region of the lung epithelium initiates an outgrowth.

TNC

GO:0060448

BP

dichotomous subdivision of terminal units involved in lung branching

The process in which a lung bud bifurcates.

CTSH

GO:0060449

BP

bud elongation involved in lung branching

The process in which a bud in the lung grows out from the point where it is formed.

SPRY2, SPRY1, BMP4, FGFR2, YAP1, RDH10

GO:0060452

BP

positive regulation of cardiac muscle contraction

Any process that increases the frequency, rate or extent of cardiac muscle contraction.

HSP90AA1, CTGF, ADRA1A, RGS2

GO:0060454

BP

positive regulation of gastric acid secretion

Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.

OPRL1, TRPV1

GO:0060455

BP

negative regulation of gastric acid secretion

Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.

OXTR, PTGER3

GO:0060460

BP

left lung morphogenesis

The process in which anatomical structures of the left lung are generated and organized.

PITX2

GO:0060463

BP

lung lobe morphogenesis

The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.

LIF, FGFR2, TGFBR2

GO:0060466

BP

activation of meiosis involved in egg activation

Any process that starts the inactive process of meiosis in an egg after the egg has been fertilized or physiologically activated. Eggs generally arrest in meiosis and complete the process after activation.

PLCB1

GO:0060479

BP

lung cell differentiation

The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate.

CTNNB1

GO:0060484

BP

lung-associated mesenchyme development

The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung.

FGFR1, FGFR2, FGF9, CTNNB1, PTK7

GO:0060485

BP

mesenchyme development

The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.

BMP2, BNC2

GO:0060486

BP

Clara cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a Clara cell. A Clara cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles.

NFIB, NKX2-1, GATA6

GO:0060487

BP

lung epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung.

YAP1, SOX9, NUMB, ASCL1, GPSM2

GO:0060491

BP

regulation of cell projection assembly

Any process that modulates the rate, frequency, or extent of cell projection assembly.

FAM110C

GO:0060492

BP

lung induction

The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung.

WNT2, CTNNB1, WNT2B

GO:0060501

BP

positive regulation of epithelial cell proliferation involved in lung morphogenesis

Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.

FOXP2, WNT2, FGF7, FGFR2, CDC42, SRSF6

GO:0060502

BP

epithelial cell proliferation involved in lung morphogenesis

The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung.

BMP4, MAP2K1

GO:0060503

BP

bud dilation involved in lung branching

The process in which a bud in the lung increases radially.

BMP4

GO:0060509

BP

Type I pneumocyte differentiation

The process in which a relatively unspecialized cell acquires specialized features of a Type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.

NFIB, THRA, CREB1, KLF2

GO:0060510

BP

Type II pneumocyte differentiation

The process in which a relatively unspecialized cell acquires specialized features of a Type II pneumocyte. A Type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies.

NFIB, NKX2-1, GATA6

GO:0060512

BP

prostate gland morphogenesis

The process in which the anatomical structures of a prostate gland are generated and organized.

FGFR2, SERPINB5

GO:0060513

BP

prostatic bud formation

The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth.

GLI2

GO:0060517

BP

epithelial cell proliferation involved in prostatic bud elongation

The multiplication of epithelial cells, contributing to the expansion of the primary prostatic bud.

SOX9

GO:0060520

BP

activation of prostate induction by androgen receptor signaling pathway

Any series of molecular signals generated as a consequence of an androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland.

AR

GO:0060523

BP

prostate epithelial cord elongation

The developmental growth process in which solid chords of prostate epithelium increase in length.

ESR1, FGFR2

GO:0060527

BP

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini.

ESR1, FGFR2, SFRP1, FRS2

GO:0060528

BP

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

The process in which a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate.

NOTCH1

GO:0060529

BP

squamous basal epithelial stem cell differentiation involved in prostate gland acinus development

The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate.

FGFR2

GO:0060532

BP

bronchus cartilage development

The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

SOX9

GO:0060534

BP

trachea cartilage development

The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

SOX9

GO:0060535

BP

trachea cartilage morphogenesis

The process in which the anatomical structures of cartilage in the trachea are generated and organized.

LRP6

GO:0060536

BP

cartilage morphogenesis

The process in which the anatomical structures of cartilage are generated and organized.

SNAI2, MEF2C

GO:0060538

BP

skeletal muscle organ development

The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue.

LARGE

GO:0060539

BP

diaphragm development

The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs.

TCF21, ASS1, WT1, DISP1

GO:0060541

BP

respiratory system development

The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.

TCF21

GO:0060544

BP

regulation of necroptotic process

Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.

CFLAR, BIRC3

GO:0060545

BP

positive regulation of necroptotic process

Any process that increases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.

RIPK1

GO:0060546

BP

negative regulation of necroptotic process

Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.

SLC25A4, CAV1, FADD, BIRC3, ARHGEF2

GO:0060547

BP

negative regulation of necrotic cell death

Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.

NOL3, MT3

GO:0060548

BP

negative regulation of cell death

Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

CYR61, NPC1, CHMP2A, BNIP3L, PARK2, VPS4B, WISP2, WISP1, CST3, FGF2, HSPA1A, HSPA1B, BMP4, CTGF, ADCYAP1R1, HTR2B, SOX4, BNIP3, SRSF6, SMAD4, PRKD1, TEAD2, ADNP2, AGR3, ZFPM2, PACRG, NPAS2, CHMP4B, CACYBP, RAD18, IMPACT

GO:0060557

BP

positive regulation of vitamin D biosynthetic process

Any process that increases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).

TNF

GO:0060558

BP

regulation of calcidiol 1-monooxygenase activity

Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.

VDR

GO:0060559

BP

positive regulation of calcidiol 1-monooxygenase activity

Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.

TNF, IL1B

GO:0060561

BP

apoptotic process involved in morphogenesis

Any apoptotic process that contributes to the shaping of an anatomical structure.

CRYAB, PPP2R1B

GO:0060562

BP

epithelial tube morphogenesis

The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.

PRKX

GO:0060563

BP

neuroepithelial cell differentiation

The process in which epiblast cells acquire specialized features of neuroepithelial cells.

CDH2, SOX4, B9D1

GO:0060566

BP

positive regulation of DNA-templated transcription, termination

Any process that increases the rate, frequency or extent of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.

SETX

GO:0060571

BP

morphogenesis of an epithelial fold

The morphogenetic process in which an epithelial sheet bends along a linear axis.

EGFR, AR

GO:0060574

BP

intestinal epithelial cell maturation

The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus.

TYMS, CDKN1A, HIF1A

GO:0060575

BP

intestinal epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine.

GATA4, GATA6

GO:0060576

BP

intestinal epithelial cell development

The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure.

YIPF6

GO:0060577

BP

pulmonary vein morphogenesis

The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart.

PITX2

GO:0060578

BP

superior vena cava morphogenesis

The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart.

PITX2

GO:0060579

BP

ventral spinal cord interneuron fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses.

ASCL1, DLL4

GO:0060585

BP

positive regulation of prostaglandin-endoperoxide synthase activity

Any process that increases the rate, frequency or extent of prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.

EDN1, EDN2

GO:0060586

BP

multicellular organismal iron ion homeostasis

Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism.

BMP6, SLC11A1, SLC11A2, HAMP, HYAL2, HFE, BTBD9, SLC40A1

GO:0060587

BP

regulation of lipoprotein lipid oxidation

Any process that modulates the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group.

LEP

GO:0060588

BP

negative regulation of lipoprotein lipid oxidation

Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group.

APOD

GO:0060591

BP

chondroblast differentiation

The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.

CYR61, FGF2, GDF5

GO:0060592

BP

mammary gland formation

The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme.

BMP4

GO:0060594

BP

mammary gland specification

The regionalization process in which the mammary line is specified. The mammary line is a ridge of epidermal cells that will form the mammary placodes.

GLI3

GO:0060595

BP

fibroblast growth factor receptor signaling pathway involved in mammary gland specification

The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes.

FGFR2

GO:0060598

BP

dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis

The process in which the terminal end of a mammary duct bifurcates.

AREG

GO:0060599

BP

lateral sprouting involved in mammary gland duct morphogenesis

The process in which a branch forms along the side of a mammary duct.

AR, WNT5A

GO:0060601

BP

lateral sprouting from an epithelium

The process in which a branch forms along the side of an epithelium.

FGFR2

GO:0060603

BP

mammary gland duct morphogenesis

The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk.

CSF1R, GLI2, PTCH1

GO:0060612

BP

adipose tissue development

The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.

SH3PXD2B, LRP5, XBP1, LEP, PIK3CA, OXCT1, SOX8, ID2, PPARD, ARID5B, AACS, SPG20, FTO, EBF2, PPARGC1A

GO:0060613

BP

fat pad development

The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue.

ARID5B, ARRDC3, DGAT2, TBL1XR1

GO:0060615

BP

mammary gland bud formation

The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis.

FGFR2

GO:0060620

BP

regulation of cholesterol import

Any process that modulates the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle.

LAMTOR1

GO:0060621

BP

negative regulation of cholesterol import

Any process that decreases the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle.

APOA2, APOC3

GO:0060623

BP

regulation of chromosome condensation

Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

CCNB1, WAPL

GO:0060627

BP

regulation of vesicle-mediated transport

Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.

NRP1, USP6, RAB11A, VAMP2, SLC30A8

GO:0060628

BP

regulation of ER to Golgi vesicle-mediated transport

Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.

GAS1, YIPF5

GO:0060632

BP

regulation of microtubule-based movement

Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.

MAPT, IGBP1, HDAC6

GO:0060633

BP

negative regulation of transcription initiation from RNA polymerase II promoter

Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.

ZNF451

GO:0060638

BP

mesenchymal-epithelial cell signaling

Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted.

WNT5A, WNT2B

GO:0060644

BP

mammary gland epithelial cell differentiation

The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland.

IRF6, PRLR, CEBPB, AKT1, AKT2, PTCH1, ERBB4, ELF5

GO:0060648

BP

mammary gland bud morphogenesis

The process in which anatomical structures of the mammary gland buds are generated and organized. Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord.

SOSTDC1

GO:0060661

BP

submandibular salivary gland formation

The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed.

CDC42

GO:0060662

BP

salivary gland cavitation

The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland.

NFIB, TGM2

GO:0060664

BP

epithelial cell proliferation involved in salivary gland morphogenesis

The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland.

TNF, IL6, FGFR2

GO:0060665

BP

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium.

FGFR1, HGF, FGF7

GO:0060666

BP

dichotomous subdivision of terminal units involved in salivary gland branching

The process in which a salivary epithelial cord bifurcates at its end.

NRP1, SEMA3A, SEMA3C, PLXNA1, PLXND1

GO:0060667

BP

branch elongation involved in salivary gland morphogenesis

The differential growth of the salivary branches along their axis, resulting in the growth of a branch.

FGFR2

GO:0060668

BP

regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling

Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the extracellular matrix to the epithelium of the salivary gland.

NTN4

GO:0060669

BP

embryonic placenta morphogenesis

The process in which the embryonic placenta is generated and organized.

CDKN1C, TRIM28

GO:0060670

BP

branching involved in labyrinthine layer morphogenesis

The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer.

SOCS3, FGFR2, IL10, ADM, GRB2, RSPO3

GO:0060672

BP

epithelial cell morphogenesis involved in placental branching

The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta.

SPINT2

GO:0060674

BP

placenta blood vessel development

The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure.

ARID1A, SOCS3, FOSL1, NR2F2, ITGB8, PKD1, MAP2K1, PKD2, RBM15

GO:0060675

BP

ureteric bud morphogenesis

The process in which the ureteric bud is generated and organized.

HES1