GO:0043551

BP

regulation of phosphatidylinositol 3-kinase activity

Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring.

KLF4, PIK3R1, CCKBR

GO:0043552

BP

positive regulation of phosphatidylinositol 3-kinase activity

Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.

PDGFB, TGFB1, LYN, FGF2, PDGFRB, FGR, KIT, PDGFRA, IRS1, CDC42, RAC1, TEK, PTK2, PIK3R4, VAV3

GO:0043553

BP

negative regulation of phosphatidylinositol 3-kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity.

WASH1

GO:0043555

BP

regulation of translation in response to stress

Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

RPS6KA1

GO:0043567

BP

regulation of insulin-like growth factor receptor signaling pathway

Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.

IGFBP1, IGFBP3, IGFBP2, IGFBP4, IGFBP6

GO:0043568

BP

positive regulation of insulin-like growth factor receptor signaling pathway

Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.

GH1, GHRH, IGF1, AR, IGFBP3, IGFBP4, IGFBP5, PHIP, GHSR

GO:0043569

BP

negative regulation of insulin-like growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.

CILP, BMP2, IGFBP5

GO:0043570

BP

maintenance of DNA repeat elements

Any process involved in sustaining the fidelity and copy number of DNA repeat elements.

MSH3, MSH2, TCF7L2

GO:0043576

BP

regulation of respiratory gaseous exchange

Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.

NR4A2, PASK, APLN

GO:0043583

BP

ear development

The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.

BCL2L11, BCL2, ECE1, DDR1, TCF15, SHROOM2, RDH10

GO:0043584

BP

nose development

The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).

RDH10, CHD7

GO:0043585

BP

nose morphogenesis

The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).

GLI3, SKI

GO:0043586

BP

tongue development

The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.

EGFR, GLI3, BNC2

GO:0043587

BP

tongue morphogenesis

The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.

TBX1, KRT13, CYP26B1

GO:0043588

BP

skin development

The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.

COL3A1, PDGFA, COL5A2, JUP, ITGB4, COL5A1, ITGA6, COL5A3, ITGA3, KRT9, PKD1, TCF15, DHCR24, SLC27A4, FRAS1, WDR48, ARRDC3, ABCB6, SUFU

GO:0043589

BP

skin morphogenesis

The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.

COL1A1, COL1A2, ITGA2, PSEN1, ERRFI1

GO:0043603

BP

cellular amide metabolic process

The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.

CYP2C9

GO:0043615

BP

astrocyte cell migration

The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord.

CCL3, CCL2, MMP14, APCDD1

GO:0043616

BP

keratinocyte proliferation

The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.

IRF6, EREG, CDH13, PPARD, PTCH1, FERMT1

GO:0043618

BP

regulation of transcription from RNA polymerase II promoter in response to stress

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

MUC1

GO:0043619

BP

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

HMOX1, ARNT, HIF1A, EPAS1

GO:0043620

BP

regulation of DNA-templated transcription in response to stress

Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

DDIT3, RPS6KA1, BCLAF1

GO:0043622

BP

cortical microtubule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.

EZR, DLG1, TRPV4

GO:0043623

BP

cellular protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell.

AXIN1, FGA, FGB, FGG, DMD, CCL5, ATF1, NLRP5, PDE4DIP

GO:0043627

BP

response to estrogen

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.

TNFRSF11B, MSTN, CYP27B1, DHH, SMAD6, LDHA, CA2, APOA1, APOA2, BGLAP, ESR1, HSP90AA1, KRT19, HMOX1, PDGFRB, GLI3, HSPD1, ARSB, IGFBP2, SRD5A1, GSTM3, GAL, DTYMK, IL4R, CD24, MAPK1, CTNNA1, TGFBR2, PPARG, BRCA1, STAR, MMP14, TEK, CAV1, EP300, TRIM25, RBBP5, TPH2, CRIPAK, GATA6, CITED4, CITED1, CITED2, ASH2L, GHRL

GO:0043631

BP

RNA polyadenylation

The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.

PAPOLA, PAPD4, PNPT1, PAPOLG

GO:0043647

BP

inositol phosphate metabolic process

The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.

INPP4B, SYNJ1, NUDT3, PLCG2, ITPKA, IMPA1, INPP1, PLCD1, PTEN, CALM2, OCRL, ITPK1, INPP5A, PPIP5K1, NUDT10, INPP5D, NUDT11, INPP4A, ISYNA1, PLCB1, IP6K2, MINPP1

GO:0043648

BP

dicarboxylic acid metabolic process

The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).

ACOT4, GRHPR

GO:0043649

BP

dicarboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups.

ACOT8, ACOT4

GO:0043651

BP

linoleic acid metabolic process

The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.

FADS1, FADS2, GSTA1, GSTP1, GSTM2, ACSL1, ELOVL1, PNPLA8, ELOVL5

GO:0043652

BP

engulfment of apoptotic cell

The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.

THBS1, RAC1

GO:0043653

BP

mitochondrial fragmentation involved in apoptotic process

The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form.

BAX, BNIP3, ERBB4, CCAR2, MFF

GO:0043654

BP

recognition of apoptotic cell

The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis.

FCN2, PEAR1, JMJD6, SCARB1, MEGF10

GO:0043666

BP

regulation of phosphoprotein phosphatase activity

Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.

DRD2, HSP90B1, PPP1R2, PPP2R4, PPP6R1

GO:0043686

BP

co-translational protein modification

The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome.

STT3A, STT3B

GO:0043687

BP

post-translational protein modification

The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.

ICMT, STS, ARSA, ARSB, STT3A, ARSD, ARSK, MINA, SUMF1, STT3B, RHBDD1

GO:0043691

BP

reverse cholesterol transport

The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism.

ABCA1, APOA1, APOE, APOA2, APOC3, CLU, APOA5, SCARB1, ABCA5, LIPG

GO:0043697

BP

cell dedifferentiation

The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.

CDK6

GO:0043922

BP

negative regulation by host of viral transcription

Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription.

JUN, CCL3, CCL4, CCL5, HMGA2, TARDBP, HDAC1, INPP5K, ZNF639

GO:0043923

BP

positive regulation by host of viral transcription

Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

CHD1, CCNT1, JUN, SMARCA4, EP300, TAF11, NUCKS1, ZNF639

GO:0043928

BP

exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.

LSM3, LSM6, EXOSC9, EXOSC2, EXOSC7, EXOSC6, DCP2, EXOSC8, EDC3, EXOSC4, EXOSC3, CNOT7, LSM7, CNOT6, DIS3, LSM2, LSM5, LSM4

GO:0043931

BP

ossification involved in bone maturation

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.

RHOA

GO:0043932

BP

ossification involved in bone remodeling

The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli.

TGFB1, CTHRC1

GO:0043947

BP

positive regulation by host of symbiont catalytic activity

Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.

SUGT1

GO:0043949

BP

regulation of cAMP-mediated signaling

Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.

GNAI1, RASD2

GO:0043950

BP

positive regulation of cAMP-mediated signaling

Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.

PF4, ADRB1, LHCGR

GO:0043951

BP

negative regulation of cAMP-mediated signaling

Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.

RGS2, CDC34, UBE2B, PDE3B, CRTC3

GO:0043966

BP

histone H3 acetylation

The modification of histone H3 by the addition of an acetyl group.

PER1, MAP3K7, TADA2A, SUPT3H, TADA3, SUPT7L, BRCA2, DR1, TAF10, JADE1, KAT6B, JADE3, KAT6A, KAT2B, TADA1, ELP4, SGF29, CSRP2BP, ELP3, TAF9B, POLE4, POLE3, YEATS2

GO:0043967

BP

histone H4 acetylation

The modification of histone H4 by the addition of an acetyl group.

APBB1, PER1, TADA3, YEATS4, ACTL6A, BRCA2, EP300, MORF4L2, NCOA1, ELP4, NAA50, EPC1, NAA60, ELP3, ING3, MORF4L1, USP22, RUVBL2, RUVBL1, TRRAP

GO:0043968

BP

histone H2A acetylation

The modification of histone H2A by the addition of an acetyl group.

YEATS4, ACTL6A, MORF4L2, EPC1, MEAF6, ING3, MORF4L1, RUVBL2, RUVBL1, TRRAP

GO:0043969

BP

histone H2B acetylation

The modification of histone H2B by the addition of an acetyl group.

EP300

GO:0043970

BP

histone H3-K9 acetylation

The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone.

KAT2B

GO:0043981

BP

histone H4-K5 acetylation

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone.

OGT, JADE1, JADE3, PHF20, MEAF6, KANSL3

GO:0043982

BP

histone H4-K8 acetylation

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone.

OGT, JADE1, JADE3, PHF20, MEAF6, KANSL3

GO:0043983

BP

histone H4-K12 acetylation

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone.

JADE1, JADE3, MEAF6

GO:0043984

BP

histone H4-K16 acetylation

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone.

OGT, MSL1, PHF20, KANSL3

GO:0043985

BP

histone H4-R3 methylation

The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone.

PRMT6, PRMT1

GO:0043987

BP

histone H3-S10 phosphorylation

The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone.

RPS6KA5, VRK1

GO:0043988

BP

histone H3-S28 phosphorylation

The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone.

RPS6KA5, AURKB

GO:0043990

BP

histone H2A-S1 phosphorylation

The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone.

RPS6KA5

GO:0044027

BP

hypermethylation of CpG island

An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.

GSK3B

GO:0044029

BP

hypomethylation of CpG island

An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.

PIK3CA

GO:0044030

BP

regulation of DNA methylation

Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.

MBD3, PARP1, BRCA1, MPHOSPH8, MIS18A

GO:0044053

BP

translocation of peptides or proteins into host cell cytoplasm

The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm.

TCP1

GO:0044065

BP

regulation of respiratory system process

Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system.

MTG1, FTO, MTG2

GO:0044070

BP

regulation of anion transport

Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

AHCYL1, CA2, STC1, RAB11B, LRRC8A, LRRC8C, TTYH1

GO:0044088

BP

regulation of vacuole organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.

MTM1

GO:0044089

BP

positive regulation of cellular component biogenesis

Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.

LDB2

GO:0044090

BP

positive regulation of vacuole organization

Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.

KIAA1324

GO:0044117

BP

growth of symbiont in host

The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.

PGLYRP2

GO:0044128

BP

positive regulation of growth of symbiont in host

Any process in which the symbiont activates, maintains or increases its size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction.

OSBP

GO:0044130

BP

negative regulation of growth of symbiont in host

Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction.

TNF, MPO, MBL2, CD36, IL10, TIRAP, SQSTM1

GO:0044154

BP

histone H3-K14 acetylation

The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone.

MEAF6

GO:0044205

BP

de novo' UMP biosynthetic process

The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen.

UMPS, CAD, DHODH

GO:0044206

BP

UMP salvage

Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis.

UPP2, UPP1, UCK2, UCK1, UCKL1

GO:0044208

BP

de novo' AMP biosynthetic process

The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).

ADSS, ADSL, ADSSL1

GO:0044209

BP

AMP salvage

The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis.

APRT

GO:0044210

BP

de novo' CTP biosynthetic process

The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components.

CTPS1, CTPS2

GO:0044211

BP

CTP salvage

Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis.

UCK2, UCK1, UCKL1

GO:0044236

BP

multicellular organism metabolic process

The chemical reactions and pathways in a single multicellular organism that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required.

GHR

GO:0044241

BP

lipid digestion

The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.

LIPH, LMF1, LIPG

GO:0044242

BP

cellular lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.

MT3, SIRT2

GO:0044245

BP

polysaccharide digestion

The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism.

MGAM, LCT

GO:0044252

BP

negative regulation of multicellular organismal metabolic process

Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level.

ARRDC3

GO:0044255

BP

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

HDAC3, TBL1X, SIN3B, NCOR1, ECI2, NUDT7, GPD2, NR1H2, PPARA, NCOA2, NCOA1, CHD9, SMARCD3, PNPLA5, CARM1, CREBBP, HELZ2, TBL1XR1, HAO2, FAM135A, NCOR2

GO:0044257

BP

cellular protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

DENND3, SIAH2, PARK2, APOB, PPT1, RIPK1, RAB12

GO:0044259

BP

multicellular organismal macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level.

AKR1C3

GO:0044262

BP

cellular carbohydrate metabolic process

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.

TKFC, IDNK

GO:0044265

BP

cellular macromolecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells.

CLN6

GO:0044267

BP

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.

SIAH2, PARK2, F2, PLG, CST3, PRL, INS, IGF2, APOA1, FGA, APCS, TTR, MMP1, IGF1, APP, KLK3, MMP2, IGFBP1, CTSH, FURIN, UBC, SAA1, IAPP, SFTPC, IGFBP3, IGFBP2, IGFBP4, IGFBP6, IGFBP5, ADORA2B, SNCA, LYZ, B2M, HIST1H4A, RPS27A, UBA52, HIST1H3D, H3F3A, HSPG2, MFGE8, PAPPA, TGFBI, GIGYF2, SIAH1, GATA6, LMCD1, CCDC59, DMBT1, ZDHHC2, GGA2, GGA1, ITM2B, SNCAIP

GO:0044275

BP

cellular carbohydrate catabolic process

The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.

ENOSF1

GO:0044281

BP

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.

FDX1, FXN, FDX1L

GO:0044314

BP

protein K27-linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein.

PARK2, UBE2S, UBE2T, RNF6, UBE2D4

GO:0044319

BP

wound healing, spreading of cells

The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface.

CYR61, TOR1A, FLNA, RHOA, DDR1, PDCD10, TMEFF2

GO:0044320

BP

cellular response to leptin stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.

FGB, INHBB, CCNA2, STAT3, LEP, PID1, NR4A3

GO:0044321

BP

response to leptin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].

EDN1, NR1D1, STAT3, LEPR, STAR

GO:0044324

BP

regulation of transcription involved in anterior/posterior axis specification

Any process that modulates the frequency, rate or extent of transcription that contributes to the specification of the anterior/posterior axis.

DDIT3

GO:0044328

BP

canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of endothelial cell migration.

PLPP3

GO:0044329

BP

canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of cell to cell adhesion.

PLPP3

GO:0044330

BP

canonical Wnt signaling pathway involved in positive regulation of wound healing

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in positive regulation of wound healing.

PLPP3