GO:0042760

BP

very long-chain fatty acid catabolic process

The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22.

SLC27A2, ABCD3, ACADVL, SLC27A4

GO:0042761

BP

very long-chain fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22.

ELOVL7, HACD4, HACD2, ELOVL1, ELOVL4, ELOVL6, ELOVL5, HACD3

GO:0042766

BP

nucleosome mobilization

The movement of nucleosomes along a DNA fragment.

ARID1A

GO:0042769

BP

DNA damage response, detection of DNA damage

The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal.

USP1, PARP1, UBC, PCNA, POLD1, DNAJA1, RPA3, RFC4, RFC2, RFC5, RFC3, HMGA2, RBX1, RPS27A, UBA52, UBE2B, SOX4, CUL4A, CUL4B, POLD3, MRPS26, POLD4, RAD18, DTL

GO:0042770

BP

signal transduction in response to DNA damage

A cascade of processes induced by the detection of DNA damage within a cell.

GADD45A, CASP9, BID, GRB2, SMC1A, MAPK14

GO:0042771

BP

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.

NUPR1, TP53, BCL3, CDKN1A, MSH2, BRCA2, EP300, PMAIP1, IFI16, RPS27L, DYRK2, USP28, HIPK2, DDIT4, PYCARD

GO:0042775

BP

mitochondrial ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.

SNCA

GO:0042776

BP

mitochondrial ATP synthesis coupled proton transport

The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.

ATP5H, ATP5L, COX5B, ATP5J, ATP5D, ATP5C1, ATP5O, ATP5G3, ATP5E, ATP5I, ATP5G2

GO:0042780

BP

tRNA 3'-end processing

The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA.

PTCD1, TRNT1, ELAC2

GO:0042787

BP

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein.

UBA6, WWP2, UBE2C, AURKA, SIAH2, BUB3, PARK2, BUB1B, UBR5, UBE4B, PTTG1, CDK1, FBXO45, UBC, CCNB1, CDC27, RNF144A, UBE2E1, PLK1, RBX1, RPS27A, UBA52, MDM2, CDC20, MAD2L1, OS9, CUL2, CUL3, CUL4A, CUL4B, TRIM25, HERC3, TCEB1, UBE3C, HERC4, UBR4, HECTD2, SPOPL, RNF19B, RNF111, RNF165, MAEA, RNF144B, RBBP6, HUWE1, SYVN1, C19orf68, CACUL1, SIAH1, KLHL7, KLHDC8A, HACE1, ABTB2, RNF128, MYLIP, RFFL, CUL5, ANAPC16, RMND5B, AURKB, ITCH, KLHL15, KLHL32, NEDD4L, BTBD9, UHRF1, RNF126, WWP1, ANAPC1, UBE2Z, RMND5A, SMURF2, RNF146, RNF19A, KBTBD4, KLHL28, RNF181, KLHL8, HECW2, RNF14, KLHL3, CDC23, ANAPC5, ANAPC4, FBXO10, AMFR, FZR1, ANAPC10, STUB1, RNF24, BTBD3, ARIH1

GO:0042789

BP

mRNA transcription from RNA polymerase II promoter

The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.

ATF4, FLNA, C5AR1, LMO2, ARNT, DDIT3, SREBF1, POU5F1, HIF1A, SOX17

GO:0042791

BP

5S class rRNA transcription from RNA polymerase III type 1 promoter

The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter.

GTF3C2, GTF3C4

GO:0042795

BP

snRNA transcription from RNA polymerase II promoter

The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.

ELL2, POLR2D, CCNT1, CCNT2, GTF2F2, POU2F1, POLR2E, POLR2A, POLR2B, GTF2F1, POLR2I, CDK7, POLR2J, GTF2A1, GTF2A2, POLR2K, POLR2G, POLR2L, GTF2B, NCBP1, TAF5, TAF11, SNAPC1, CPSF3L, ICE2, INTS3, INTS1, SNAPC3, NABP1, INTS4, RPRD1A, VWA9, NABP2, PHAX, INTS7, INTS10, INTS6

GO:0042796

BP

snRNA transcription from RNA polymerase III promoter

The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter.

SNAPC1, ICE2

GO:0042797

BP

tRNA transcription from RNA polymerase III promoter

The synthesis of transfer RNA (tRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter.

GTF3C2, GTF3C4

GO:0042816

BP

vitamin B6 metabolic process

The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.

PDXK, AOX1

GO:0042823

BP

pyridoxal phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6.

PDXK

GO:0042832

BP

defense response to protozoan

Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.

IL6, BCL3, IL10, IL4R, IL12A, SLC11A1, LYST, CLEC7A

GO:0042851

BP

L-alanine metabolic process

The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.

GPT2

GO:0042853

BP

L-alanine catabolic process

The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.

AGXT, GPT2

GO:0042866

BP

pyruvate biosynthetic process

The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate.

AGXT

GO:0042904

BP

9-cis-retinoic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative.

ALDH1A2, CYP1A1, DHRS9, ALDH8A1

GO:0042908

BP

xenobiotic transport

The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

ABCA8, SLC2A1

GO:0042921

BP

glucocorticoid receptor signaling pathway

Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor.

ARID1A, NR3C1, CALR, YWHAH

GO:0042930

BP

enterobactin transport

The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

ASIC3

GO:0042953

BP

lipoprotein transport

The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UNC119B, APOB, PRKCB, CD36, PPARG, LRP2, UNC119, ZDHHC17

GO:0042977

BP

activation of JAK2 kinase activity

The process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it.

JAK2, GHR, PRLR

GO:0042981

BP

regulation of apoptotic process

Any process that modulates the occurrence or rate of cell death by apoptotic process.

HAX1, HIP1, TNFRSF11B, NME4, MSTN, TNFRSF10C, BIRC5, DAPK3, ACTN4, TRIAP1, BNIP3L, GDF9, JAK2, MITF, LRP5, TNFRSF21, RSL1D1, GDF11, BMP10, BMP15, TGFB1, ESR1, RAF1, TP53, INHA, FYN, CTSB, NGFR, LGALS1, INHBB, BMP3, ACTN1, BMP1, TPT1, NME1, IGFBP3, EGR1, TNFRSF1B, BCL3, BMP6, CHM, FAS, CALR, DUSP1, CASP1, PRDX2, BMP8B, PHB, ACTN2, BRCA1, ANP32A, BCL6, GDF5, SOX9, CASP4, RBM25, DAPK1, RABGGTB, GAS1, VCP, INHBC, CASP6, BID, CRADD, CDK5, PAX8, BAX, SKP2, BIRC3, NAE1, TP53BP2, PMAIP1, DIP2A, HS1BP3, CARD16, SARM1, RASSF6, BMP8A, RASSF3, TMEM219, SERBP1, ZNF420, DLG5, FRS2, RASSF5, NDRG1, CREBBP, TNFRSF25, TP53INP1, SGK3, PERP, GDF15, AIFM2, ANP32E, CARD10, BEX2, SRA1, RTN4, LCMT1, FBXO10, PRELID1, TNFRSF11A

GO:0042982

BP

amyloid precursor protein metabolic process

The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease.

DLG1, LDLRAP1

GO:0042984

BP

regulation of amyloid precursor protein biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.

NECAB3

GO:0042985

BP

negative regulation of amyloid precursor protein biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.

ITM2A, AATF, ITM2B

GO:0042986

BP

positive regulation of amyloid precursor protein biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.

SOAT1, PAWR

GO:0042987

BP

amyloid precursor protein catabolic process

The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease.

PSEN1, PSEN2, CLN3, DHCR24, APH1A

GO:0042989

BP

sequestering of actin monomers

The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers.

TMSB15A, TMSB4X, TMSB10, TWF1, TWF2

GO:0042990

BP

regulation of transcription factor import into nucleus

Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.

AGTR2

GO:0042991

BP

transcription factor import into nucleus

The directed movement of a transcription factor from the cytoplasm to the nucleus.

SYK, IPO9

GO:0042992

BP

negative regulation of transcription factor import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.

CD36, RAB23, SUFU

GO:0042993

BP

positive regulation of transcription factor import into nucleus

Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.

HDAC3, HCLS1, FLNA, PIK3R1, SMAD3, TRIM28, MAVS

GO:0042994

BP

cytoplasmic sequestering of transcription factor

The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.

THRA, SRI, MXI1, PKD1, PKD2, TONSL, MDFI, NFKBIL1, SUFU

GO:0042997

BP

negative regulation of Golgi to plasma membrane protein transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.

LYPLA1, CSK

GO:0042998

BP

positive regulation of Golgi to plasma membrane protein transport

Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.

RACK1, CNST

GO:0043000

BP

Golgi to plasma membrane CFTR protein transport

The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane.

KRT18

GO:0043001

BP

Golgi to plasma membrane protein transport

The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.

NSF, VAMP7, VAMP2, SPTBN1, ANK3, GOLGA4, RAB31, VAMP3, BBS1, OPTN, BBS2, RAB34, BLZF1, MACF1

GO:0043004

BP

cytoplasmic sequestering of CFTR protein

The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane.

GOPC

GO:0043006

BP

activation of phospholipase A2 activity by calcium-mediated signaling

A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal.

EGFR

GO:0043009

BP

chordate embryonic development

The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.

FGFR1, BRCA1, CENPU

GO:0043010

BP

camera-type eye development

The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.

FOXP2, CYP1A1, SKI, WT1, FBN1, FBN2, GPD2, CDKN1C, EFEMP1, FOXC1, MAB21L1, SHROOM2, CACNA1C, RAB3GAP1, RCN1, PITX2, CC2D2A, B9D1

GO:0043011

BP

myeloid dendritic cell differentiation

The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.

UBD, TGFB1, LTBR, TGFBR2, PSEN1, RELB

GO:0043012

BP

regulation of fusion of sperm to egg plasma membrane

Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane.

NOX5

GO:0043029

BP

T cell homeostasis

The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.

BCL2L11, CCNB2, TGFB1, BCL2, RAG1, CORO1A, STAT5B, JAK3, FADD, PMAIP1, SLC46A2, FOXP3, RC3H2

GO:0043030

BP

regulation of macrophage activation

Any process that modulates the frequency or rate of macrophage activation.

CD74, MIF, RORA, SNCA, SLC7A2, SHPK

GO:0043031

BP

negative regulation of macrophage activation

Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.

CD200, NR1H3

GO:0043032

BP

positive regulation of macrophage activation

Any process that stimulates, induces or increases the rate of macrophage activation.

IL33, THBS1, HSPD1, IL10, IL4R, WNT5A, IL1RL1

GO:0043041

BP

amino acid activation for nonribosomal peptide biosynthetic process

Activation of an amino acid for incorporation into a peptide by a nonribosomal process.

AASDH

GO:0043043

BP

peptide biosynthetic process

The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide.

FURIN, DMD, PCSK1, PCSK5, MRPS26

GO:0043044

BP

ATP-dependent chromatin remodeling

Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors.

ARID1A, SMARCA5, MBD3, ACTL6A, HNRNPC, SMARCA1, SMARCA4, ACTB, RBBP4, HDAC1, CHD4, SMARCC2, HDAC2, SMARCC1, SMARCAD1, CHD8

GO:0043045

BP

DNA methylation involved in embryo development

The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression.

TRIM28

GO:0043046

BP

DNA methylation involved in gamete generation

The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.

PIWIL4, TDRD9, CTCFL

GO:0043049

BP

otic placode formation

The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain.

PROX1

GO:0043060

BP

meiotic metaphase I plate congression

The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I.

MLH1

GO:0043062

BP

extracellular structure organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.

TGFBR1

GO:0043063

BP

intercellular bridge organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another.

TEX14

GO:0043065

BP

positive regulation of apoptotic process

Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.

USP27X, APBB1, DFFA, SAP18, BIN1, DDX3X, PDCD5, UBD, TLR3, DAPK3, EEF1E1, RIPK2, BCL2L11, FOXO3, BNIP3L, NUPR1, GADD45B, ARL6IP5, ALDH1A2, SLIT2, PLEKHG5, UNC5C, GADD45G, AIFM1, LATS1, LDHA, KNG1, TGFB1, NGF, TNF, S100B, TP53, IL6, ITGB1, NGFR, HMGB1, HMOX1, PDGFRB, UBC, HSPD1, TOP2A, IGF2R, CDK4, BMP2, BMP4, FOSL1, VAV1, CREB1, IGFBP3, ATF4, ATF6, CNR1, TGM2, GAL, ITGA6, GADD45A, APC, FAS, DUSP1, TNFRSF8, TSPO, DNAJA1, AKT1, CTNNB1, ADM, PTGS2, SNCA, BCL6, MNDA, MAPK8, NOTCH1, ALDH1A3, PSEN1, PSEN2, TNFSF10, MAP2K6, RBM5, HMGA2, BID, FOXL2, RHOB, RPS6, RPS27A, UBA52, RAC1, RACK1, PRKDC, GPLD1, DHODH, ID3, ZBTB16, EEF1A2, SOX4, C1QBP, BAX, SOS1, SOS2, PPID, FOXO1, KCNMA1, AKAP13, GRIN2A, ABR, BNIP3, TIAM1, MLLT11, STK4, EIF2B5, FADD, ITGB3BP, SQSTM1, RIPK1, PMAIP1, ARHGEF7, ZNF268, MELK, PPP2R4, RNPS1, ERBB4, ANKRD1, RPS6KA2, TRADD, NCOA1, ITSN1, PDCD2, CYP1B1, DUSP6, ANO6, ARHGEF16, SFRP4, SHQ1, ADAMTSL4, NET1, FGD2, CAMK1D, SIAH1, CCAR2, SFRP1, JMY, TRPV1, FLCN, LILRB1, APH1B, CSRNP3, NSMAF, INPP5D, APBB2, BAD, ARHGEF2, FAM162A, APH1A, MOAP1, PAWR, FGD4, GPER1, MAP3K5, BARD1, AIFM2, CDK19, TXNIP, SUDS3, PLEKHG2, ECT2, TNFRSF12A, NOX4, ARHGEF4, ARHGEF3, LATS2, ING3, BCLAF1, ZAK, IP6K2, DDX20, OSGIN1, VAV3, PNMA3, PNMA2, PYCARD, BOK, FAF1, TRIM35

GO:0043066

BP

negative regulation of apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

HAX1, DDX3X, CYR61, SOCS2, SOCS3, AURKA, MDM4, HDAC3, BIRC5, CFLAR, SIAH2, PAX4, RIPK2, SMAD6, SPRY2, TRIAP1, BNIP3L, GREM1, FCMR, NOL3, PSMD10, MAP4K4, DDAH2, EGFR, TIMP1, MYC, NGF, GNRH1, GCG, CRYAB, ALB, RAF1, ANXA1, PRNP, CD74, TP53, HSPB1, IGF1, MPO, IL6, KRT18, CDK1, NPM1, CSF1R, THBS1, IGF1R, NGFR, ASNS, ANXA5, GSTP1, ANXA4, PDGFRB, CTSH, UBC, GLI2, GLI3, BCL2, HSPD1, HSPA5, BMP4, UNG, TDGF1, TPT1, MIF, HSP90B1, MMP9, NQO1, VEGFA, CD44, EPCAM, PRLR, XBP1, ARF4, SON, WT1, NFKB1, BCL3, CAPN3, FLNA, IL10, NME2, CFL1, FAS, MT3, CD27, PIK3R1, DUSP1, LTK, CD40LG, CCND2, PPIF, ADORA1, DNAJA1, AKT1, PRDX2, GRK5, BTC, FLT4, NUP62, SNCA, CDKN1A, IL6ST, STAT3, ID1, LEP, WNT5A, HTR2B, PRKCI, PTGFR, MAPK8, CDKN1B, IER3, SOX9, GCLC, COMP, PSEN1, PSEN2, GSK3B, MRE11A, SERPINB9, ASCL1, PPT1, IRAK1, STAT5B, ARHGDIA, HMGA2, PLK1, PRKAA2, UCP2, SOX8, ADAMTS20, PTEN, RPS3A, DAD1, RPS6, RPS27A, UBA52, YWHAZ, UBE2B, ACTC1, PRKDC, TMF1, SMAD3, DAB2, XIAP, TEK, PPARD, PLAUR, RELA, NOTCH2, GLO1, PTK2, EGR3, MCL1, FOXO1, BNIP3, PAK2, DNAJC3, MAD2L1, CLN3, BIRC3, SQSTM1, HDAC1, GAS6, PDE3A, ZNF268, ARL6IP1, KIF14, ERBB4, ANGPT1, DHCR24, RPS6KA1, STIL, RGN, TWIST1, NPY5R, ASIC2, FXN, PDCD4, ZFAND6, SETX, MTDH, TAX1BP1, ANKLE2, CAMK1D, SUPV3L1, AHI1, SFRP1, OSR1, RHBDD1, PHIP, HDAC2, BCL2L2, KIFAP3, APBB2, GATA6, MYDGF, ITCH, NR1H4, FAM129B, PHB2, BARD1, CIB1, CITED2, PDCD10, HTATIP2, NAA15, WNK3, TAF9B, AGO4, SLC40A1, CHST11, ATAD3A, AATF, SPHK1, PLK2, FMN2, GHRL, PA2G4, HIGD1A, PRELID1

GO:0043067

BP

regulation of programmed cell death

Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

CST3

GO:0043068

BP

positive regulation of programmed cell death

Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

TNF, NTRK1, CDKN1A, BNIP3, RIPK1, MARK4

GO:0043069

BP

negative regulation of programmed cell death

Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

ALB, KIT, PLCG2, NUP62, KANK2

GO:0043084

BP

penile erection

The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.

ACVR2A

GO:0043085

BP

positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.

SH3PXD2B, AZIN1, OGT, CFLAR, PPP1R12B, PRKRA, IGF2, APOA2, APOC1, NPM1, PSAP, CXCL1, BCL2, IGFBP3, MT3, YWHAB, GTF2F1, TRIM23, NR4A2, PSEN1, PSEN2, MMP15, MMP16, ARF1, CAV1, STX4, NCF4, HSPB2, FXN, PITRM1, RICTOR, NOXA1, PHACTR4, APH1B, NSMAF, APH1A, MGST2, CIB1, SAE1, DBF4, GTF3C4, PLAA, MMP24

GO:0043086

BP

negative regulation of catalytic activity

Any process that stops or reduces the activity of an enzyme.

ACACB, PPP1R12A, HNRNPR, ENSA, PHACTR2, OAZ2, TIMP1, SCG5, ANXA2, ANXA5, ANXA4, ANXA3, RNH1, NQO1, PDC, PLN, SERPINB3, PPP1R2, NOTCH1, NES, OAZ1, ARPP19, SET, CLN3, FRY, CAND1, CCAR2, PPP1R14C, TMBIM1, PPP1R14A, PPP1R14B, FAF2, PPP1R10, ANP32E, TXNIP, PPME1, CABIN1

GO:0043087

BP

regulation of GTPase activity

Any process that modulates the rate of GTP hydrolysis by a GTPase.

ITGB1BP1, PLXNB2, ADAP1, VAV1, EPHA3, RDX, BCL6, PLXNA3, EFNA5, EPHA5, EPHA4, DYNLT1, OCRL, PTK2, ARHGEF5, RAB3GAP1, RALBP1, NTRK2, RICTOR, FGD6, SYDE1, FGD2, IQGAP3, BVES, TBC1D15, RAPGEF6, AJUBA, FGD4, MLST8, RAB3GAP2, STMN3, VAV3, PYCARD

GO:0043091

BP

L-arginine import

The directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle.

SLC11A1

GO:0043097

BP

pyrimidine nucleoside salvage

Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis.

TK2, UPP2, TK1, TYMP, DCK, UPP1, UPRT, UCK2, UCK1, UCKL1

GO:0043101

BP

purine-containing compound salvage

Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis.

PNP, ADA, APRT, DCK, GMPR, AMPD3, MTAP, DGUOK

GO:0043103

BP

hypoxanthine salvage

Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis.

ADA

GO:0043111

BP

replication fork arrest

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork.

TIPIN

GO:0043112

BP

receptor metabolic process

The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

FUT8

GO:0043113

BP

receptor clustering

The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.

ITGB1BP1, ITGB2, FLNA, CDK5, DLG1, MAGI2, SYNGAP1

GO:0043114

BP

regulation of vascular permeability

Any process that modulates the extent to which blood vessels can be pervaded by fluid.

BCR, NPPB, HRH1, TEK, ABR

GO:0043116

BP

negative regulation of vascular permeability

Any process that reduces the extent to which blood vessels can be pervaded by fluid.

SLIT2, ADM, TJP1, PTPRJ, PDE3A, ANGPT1

GO:0043117

BP

positive regulation of vascular permeability

Any process that increases the extent to which blood vessels can be pervaded by fluid.

TGFB1, CXCR2, PDE3A, TRPV4

GO:0043122

BP

regulation of I-kappaB kinase/NF-kappaB signaling

Any process that modulates I-kappaB kinase/NF-kappaB signaling.

TNF, IL1B, HSPB1, CAPN3, F2RL1, SQSTM1, ANGPT1, ZFAND6, OPTN, BTRC

GO:0043123

BP

positive regulation of I-kappaB kinase/NF-kappaB signaling

Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.

GPR89A, TRIM38, TNFSF11, UBD, CFLAR, MAP3K7, RIPK2, TSPAN6, TRAF3IP2, PARK2, TRIM13, BRD4, PLEKHG5, BCL10, TNF, IL1A, S100B, PRKCB, FYN, LGALS1, HMOX1, GPR89B, UBC, CD36, GJA1, FLNA, TGM2, F2R, S100A4, CASP1, EEF1D, CTH, CTNNB1, LTBR, NUP62, HTR2B, TNFSF10, IRAK1, F2RL1, TIRAP, RHOA, RPS27A, UBA52, UBE2I, ATP2C1, RELA, REL, BST2, AKAP13, FADD, UBE2V1, BIRC3, RIPK1, TRIM25, CASP8, PRKD1, TRADD, ADIPOQ, WLS, CXXC5, MAVS, TMED4, MTDH, ZDHHC17, SLC44A2, TRIM22, C18orf32, SLC20A1, SECTM1, TFG, MIB2, PELI1, AJUBA, S100A13, LITAF, NDFIP1, TRIM62, PINK1, TRIM8, ECT2, PELI2, NEK6, TNFRSF19, NDFIP2, PLK2, GPRC5B, VAPA, TBK1, GOLT1B

GO:0043124

BP

negative regulation of I-kappaB kinase/NF-kappaB signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.

PER1, PPM1B, ESR1, GSTP1, TNFAIP3, RORA, IL1RL1, TLE1, RIPK1, CASP8, ZMYND11, ADIPOQ, OTUD7B, TANK, OPTN, CARD19, NR1H4, ASH1L, PYCARD

GO:0043128

BP

positive regulation of 1-phosphatidylinositol 4-kinase activity

Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase.

CD81

GO:0043129

BP

surfactant homeostasis

Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.

CTSH, VEGFA, EPAS1

GO:0043132

BP

NAD transport

The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH.

SLC25A17

GO:0043134

BP

regulation of hindgut contraction

Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.

GHSR

GO:0043137

BP

DNA replication, removal of RNA primer

Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.

RNASEH2A, FEN1, DNA2

GO:0043149

BP

stress fiber assembly

The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.

ITGB5, RHOA, CUL3, ZYX, KCTD13, SORBS1

GO:0043152

BP

induction of bacterial agglutination

Any process in which infecting bacteria are clumped together by a host organism.

FGA, FGB, SPON2, DMBT1

GO:0043153

BP

entrainment of circadian clock by photoperiod

The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).

BHLHE40, PER1, USP2, TP53, PPP1CC, SIK1, PPP1CA, PPP1CB, ID2, MTA1, CRY1, RBM4B, RBM4

GO:0043154

BP

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.

DDX3X, SIAH2, KLF4, TRIAP1, DNAJB6, NGF, CRYAB, RAF1, IL6, GPI, GPX1, THBS1, NGFR, HGF, VEGFA, RAG1, CD44, MT3, CD27, AKT1, SFN, SNCA, SERPINB9, YWHAE, IGBP1, XIAP, MDM2, MAP2K5, GAS6, ARL6IP1, DHCR24, RPS6KA1, MICAL1, FNIP1, LAMP3

GO:0043161

BP

proteasome-mediated ubiquitin-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

PSMD11, PSMD12, WWP2, ARNTL, TRIM38, UBE2C, AXIN1, PSMD3, SIAH2, BUB3, PARK2, BUB1B, TRIM13, TBL1X, PSMD10, UBE4B, TP53, CDK1, UCHL1, FBXO45, UBC, PSMC3, PSMB1, APC, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, CDC27, CTNNB1, DDIT3, PSMC2, PSMB10, PSMC4, CSNK1A1, CDC34, UBE2A, PSMB3, GSK3B, PSMD7, UBE2E1, ATXN3, RAD23A, RAD23B, VCP, UBE2D3, PSME3, PSMC1, UBE2H, PSMC6, PPP2CB, RBX1, RPS27A, UBA52, UBE2B, SKP1, CDC20, PSMD2, MAD2L1, MTA1, PPP2R5C, CUL3, CUL4A, PSME4, KIF14, SPOPL, RNF111, RNF165, MAEA, C19orf68, SIAH1, SIRT2, ABTB2, KCTD13, RFFL, FBXW5, UBE2W, ANAPC16, RMND5B, NEDD4L, BTBD9, RNF126, TBL1XR1, TRIM9, USP44, RNF38, WWP1, ANAPC1, KCTD10, RMND5A, RLIM, KBTBD4, RNF216, GTSE1, RNF181, KLHL42, CDC23, ANAPC5, ANAPC4, ANAPC10, STUB1, FAF1, NSFL1C, RNF24, RNF6, BTRC, BTBD3

GO:0043162

BP

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.

UBAP1L, VPS4B, VPS37A, MVB12A, NDFIP1, RNF126, HDAC6

GO:0043171

BP

peptide catabolic process

The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.

TPP1, ACE, NPEPPS, ERAP2, AOPEP, ERAP1, LNPEP, CPQ, LOC440434

GO:0043179

BP

rhythmic excitation

Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit.

EDN1

GO:0043181

BP

vacuolar sequestering

The process of transporting a substance into, and confining within, a vacuole.

GAA

GO:0043200

BP

response to amino acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.

IL6, EDN1, ICAM1, LYN, ASNS, GSTP1, CCL2, ALAD, CTGF, MTHFR, SLC1A2, CDKN1B, GLRB, RELA, CDO1, BAD, RRAGC, PEMT

GO:0043201

BP

response to leucine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus.

PIK3C3, PPARGC1A