GO:0006501

BP

C-terminal protein lipidation

The covalent attachment of a lipid group to the carboxy terminus of a protein.

ATG12

GO:0006505

BP

GPI anchor metabolic process

The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain.

PIGW, PGAP3

GO:0006506

BP

GPI anchor biosynthetic process

The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.

PIGA, PIGF, PIGH, PIGY, PIGG, PIGC, PGAP3, PIGU, CWH43, DPM3

GO:0006507

BP

GPI anchor release

The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane.

GPLD1

GO:0006508

BP

proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

MASP2, TPP1, UBD, CAPN5, CFLAR, ADAM12, KLK10, DHH, NRDC, TBL1X, ADAM23, PDCD6, CAPN15, PRSS23, PAPLN, ECEL1, F8, F2, C1R, PLG, PLAU, PLAT, CFB, C3, C1QA, MMP1, CFI, KLK3, CTSD, PRSS1, CTSL, CTSB, CELA2A, CELA2B, MMP2, MME, MMP10, DLD, CTSH, C1S, C4A, C4B, MBL2, F5, BMP1, IDE, MMP9, KLK2, CAPN3, MMP8, MMP11, CTSS, MST1, DPP4, PSMB5, LAP3, PCSK1, TPP2, CASP1, PDIA3, SRI, PRSS3, DPP6, CTSK, PSMC4, PREP, CASP4, MMP14, MMP15, MMP16, THOP1, CTSC, CASP9, CASP6, NPEPPS, YBEY, ADAMTS20, SHFM1, ADAM8, OLR1, ADAM17, HTRA3, PMPCA, CBLB, PAPPA, BLMH, FGL2, WFDC2, ESPL1, CASP8, CUL7, CLCA4, PCOLCE, FCN2, NEDD8, LONRF1, LONRF2, MST1L, MMEL1, LONRF3, PREPL, PITRM1, CPZ, CTRB2, DESI1, RHBDD2, ERAP2, ADAMTSL4, THSD4, ASRGL1, ERMP1, TRABD2A, TMPRSS6, PM20D2, SFRP1, MPND, AOPEP, ADAMTS17, ADAMTS15, ADAMTS18, PIGK, HTRA1, GGH, TANK, NUDT16, STAMBPL1, CPB2, AGBL1, MMP19, TMEM59, NLN, NDEL1, ADAMTS10, CAPN10, ALG13, MMP25, NRIP3, MMP26, UFSP2, PGPEP1, C1RL, ADAMTS9, CTSZ, CTSF, ADAMTS1, USP25, LNPEP, GGT7, FBXL2, ADAM21, ADAMTS6, SUFU, ADAMTS5, ADAMTS8, AGTPBP1, RCE1, MYRF, MMP24, CPQ, XRCC6BP1, LOC440434

GO:0006509

BP

membrane protein ectodomain proteolysis

The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).

ADAM10, MYH9, RBMX, PSEN1, PSEN2, ADAM17, PRKCQ, ADAM9, DAG1, SPPL2A, APH1A, ADAM19, ERAP1

GO:0006511

BP

ubiquitin-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

UBA6, USP27X, PSMD11, UBE2C, UBD, PSMD3, SIAH2, USP12, USP2, RNF8, USP1, UBR5, UCHL3, XBP1, USP6, PSMC2, RANBP1, UBE2A, USP11, UBE2E1, TTC3, ATXN3, UBE2D3, USP46, UBE2H, PSMC6, UBE2B, UBE2I, SQSTM1, CUL7, NEDD8, UBR3, USP34, USP31, USP51, USP45, USP48, SIAH1, TP53INP2, FBXO22, USP32, FBXO25, RFFL, BAP1, UFD1L, USP13, FBXO32, ITCH, USP28, PINK1, USP42, SMURF2, CYLD, FBXO8, RLIM, DTL, USP36, USP35, USP25, FBXL7, CDC23, AMFR, STUB1, USP22, RNF6, BTRC, USP20, USP15, ARIH1, NUB1, UCHL5

GO:0006513

BP

protein monoubiquitination

Addition of a single ubiquitin group to a protein.

PEX12, PARK2, UBE4B, UBE2D3, RBX1, UBE2B, CUL3, TRIM25, KLHL12, HUWE1, UBE2W, NEDD4L, RNF126, UBE2T, RAD18, DTL, FBXL2

GO:0006515

BP

misfolded or incompletely synthesized protein catabolic process

The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.

ATXN3, LONP2, UBE2W, OMA1, YME1L1, HDAC6, STUB1

GO:0006516

BP

glycoprotein catabolic process

The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.

MGEA5, STT3B, ADAMTS9

GO:0006517

BP

protein deglycosylation

The removal of sugar residues from a glycosylated protein.

MAN2B1, MGEA5, MAN2A2, ENGASE, MAN2B2

GO:0006518

BP

peptide metabolic process

The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.

MME, CPM, CPN1, THOP1, CPZ, AEBP1, MIPEP, NLN

GO:0006520

BP

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.

QDPR, ATF4, SLC6A6, MTHFR, GLUD2, SLC7A2, SLC7A5, CLN3, SLC7A6, SCLY, SLC7A8, SLC7A7, SLC6A14, SLC25A15

GO:0006521

BP

regulation of cellular amino acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.

PSMD11, PSMD12, AZIN1, PSMD3, PSMD10, OAZ2, INS, ODC1, NQO1, PSMC3, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, PSMC2, PSMB10, PSMC4, PSMB3, PSMD7, OAZ1, PSME3, PSMC1, PSMC6, PSMD2, PSME4

GO:0006526

BP

arginine biosynthetic process

The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.

ASS1, CAD

GO:0006527

BP

arginine catabolic process

The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.

DDAH1, DDAH2, FAH, NOS3

GO:0006529

BP

asparagine biosynthetic process

The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.

ASNS

GO:0006531

BP

aspartate metabolic process

The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.

GOT2, ASS1, ADSS, ADSSL1

GO:0006532

BP

aspartate biosynthetic process

The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.

GOT2, BCAT1

GO:0006533

BP

aspartate catabolic process

The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.

GOT2

GO:0006534

BP

cysteine metabolic process

The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.

CTH, GCLC, GCLM, CDO1

GO:0006535

BP

cysteine biosynthetic process from serine

The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine.

CBS

GO:0006536

BP

glutamate metabolic process

The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.

GOT2, GCLC, GCLM, GLUD2, MTHFS, ALDH18A1

GO:0006537

BP

glutamate biosynthetic process

The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.

GLS, SLC1A3, GLUD2

GO:0006538

BP

glutamate catabolic process

The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.

GLUD2

GO:0006541

BP

glutamine metabolic process

The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.

PFAS, PHGDH, ASNS, CTPS1, CAD, GMPS, GFPT1, ADSSL1, GGH, CTPS2

GO:0006543

BP

glutamine catabolic process

The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid.

GLS, PPAT

GO:0006544

BP

glycine metabolic process

The chemical reactions and pathways involving glycine, aminoethanoic acid.

PHGDH, GART, SHMT1, DMGDH

GO:0006545

BP

glycine biosynthetic process

The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid.

DHFR

GO:0006546

BP

glycine catabolic process

The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid.

GCSH

GO:0006548

BP

histidine catabolic process

The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

HNMT

GO:0006549

BP

isoleucine metabolic process

The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.

GHR, STAT5A, STAT5B

GO:0006552

BP

leucine catabolic process

The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.

HMGCL, AUH, MCCC1, MCCC2

GO:0006554

BP

lysine catabolic process

The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.

DLD, DLST, ALDH7A1, OGDH, PHYKPL, PIPOX, AASS

GO:0006555

BP

methionine metabolic process

The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.

MTHFD1, MTHFR

GO:0006556

BP

S-adenosylmethionine biosynthetic process

The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.

MAT2A, MAT2B

GO:0006557

BP

S-adenosylmethioninamine biosynthetic process

The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt.

AMD1

GO:0006559

BP

L-phenylalanine catabolic process

The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.

GSTZ1, QDPR, FAH, ASRGL1, HGD

GO:0006560

BP

proline metabolic process

The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.

PRODH

GO:0006561

BP

proline biosynthetic process

The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.

ALDH18A1

GO:0006562

BP

proline catabolic process

The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.

PRODH

GO:0006563

BP

L-serine metabolic process

The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.

SHMT1, CBS

GO:0006564

BP

L-serine biosynthetic process

The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.

PHGDH, PSAT1

GO:0006565

BP

L-serine catabolic process

The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.

SHMT1, CBS

GO:0006566

BP

threonine metabolic process

The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.

PHGDH

GO:0006569

BP

tryptophan catabolic process

The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.

KMO, KYNU

GO:0006572

BP

tyrosine catabolic process

The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.

GSTZ1, FAH, HGD

GO:0006573

BP

valine metabolic process

The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.

GHR, STAT5A, STAT5B, ALDH6A1

GO:0006574

BP

valine catabolic process

The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.

HIBADH, ALDH6A1, HIBCH

GO:0006576

BP

cellular biogenic amine metabolic process

The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.

MAOA

GO:0006579

BP

amino-acid betaine catabolic process

The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid.

DMGDH

GO:0006580

BP

ethanolamine metabolic process

The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine).

CHKA

GO:0006582

BP

melanin metabolic process

The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.

BCL2

GO:0006583

BP

melanin biosynthetic process from tyrosine

The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.

TYR

GO:0006584

BP

catecholamine metabolic process

The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.

AOC2, SULT1A3, MTPN

GO:0006585

BP

dopamine biosynthetic process from tyrosine

The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine.

TH

GO:0006590

BP

thyroid hormone generation

The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.

DIO2, SLC5A5, DUOX2, DUOX1, CPQ

GO:0006592

BP

ornithine biosynthetic process

The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.

ALDH18A1

GO:0006595

BP

polyamine metabolic process

The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups.

OAZ2, ODC1, AMD1, SRM

GO:0006596

BP

polyamine biosynthetic process

The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups.

OAZ2, SAT1, OAZ1

GO:0006597

BP

spermine biosynthetic process

The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging.

AMD1

GO:0006600

BP

creatine metabolic process

The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.

GHR, CKB, CKMT1A, CKMT2, STAT5A, SLC6A8, GATM, STAT5B

GO:0006601

BP

creatine biosynthetic process

The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.

GATM

GO:0006605

BP

protein targeting

The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.

MYO1C, RHOD, TRAK2, RASSF9, YWHAB, RAB27A, SYNJ2BP, YWHAE, RPL11, YWHAZ, AKAP6, OS9, CDC37, PAN3, NLGN1, SORL1, KATNB1, HPS4, KIF13B, HOMER3, TRAK1

GO:0006606

BP

protein import into nucleus

The directed movement of a protein from the cytoplasm to the nucleus.

NUP155, PDIA3, FGF9, NUP62, STAT3, RANBP1, NUP153, TSC2, PTTG1IP, CSE1L, NUP107, NUTF2, RAE1, PPP3CA, KPNB1, C11orf73, NUP93, TMCO6, PRICKLE1, IPO9, PPP1R10, NUP88, NUP58, NUP85, NUP62CL, TXNIP, NUP50

GO:0006607

BP

NLS-bearing protein import into nucleus

The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane.

IPO5, KPNA3, KPNA4, TNPO2, FYB, KPNA5, RANBP6, RANBP2, KPNA2, KPNA1, CBLB, DAG1, KPNB1, NUP35, IPO4, RERE, TRPS1

GO:0006610

BP

ribosomal protein import into nucleus

The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane.

IPO5, TNPO2, RANBP6, KPNB1, IPO4

GO:0006611

BP

protein export from nucleus

The directed movement of a protein from the nucleus into the cytoplasm.

XPO1, NUPL2, AHCYL1, TGFB1, EGR2, CALR, GSK3B, CSE1L, NUTF2, EIF5A, CRB1, PKD1, NUP88, CHP1, XPO4, STRADB, NXT1

GO:0006612

BP

protein targeting to membrane

The process of directing proteins towards a membrane, usually using signals contained within the protein.

MYO1C, SDCBP, ICMT, CHM, ADORA1, PRKCI, PARD3, RAB3IP, SEC63, RABGEF1, TAOK2

GO:0006613

BP

cotranslational protein targeting to membrane

The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria.

SRP14, SSR1, TRAM2, ARL6IP1, SEC62

GO:0006614

BP

SRP-dependent cotranslational protein targeting to membrane

The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.

SRP72, RPLP1, RPLP2, RPLP0, RPS17, RPSA, RPS2, RPL35A, RPL7, RPL17, RPS4Y1, RPL13, RPL10, RPL12, RPL22, RPL4, SRP14, RPL13A, RPS27, RPL35, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, RPL29, RPL34, SRP9, RPL14, RPS20, SRP54, RPS3A, RPL26, RPL15, RPL27, RPL37A, SEC61A1, RPL37, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, RPL7A, RPL23A, RPS6, RPS25, RPS26, RPL30, RPL31, RPL10A, RPL32, RPL11, RPL41, RPS27A, UBA52, RPL38, RPS21, RPL24, RPL36A, RPL19, RPL18A, RPL18, SEC63, SSR3, RPL36, SRPRB

GO:0006616

BP

SRP-dependent cotranslational protein targeting to membrane, translocation

The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.

SRP9, SRP54, ZFAND2B

GO:0006617

BP

SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition

The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting.

SRP54

GO:0006620

BP

posttranslational protein targeting to membrane

The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.

SEC61A1, SEC62, CHMP4B, SEC63

GO:0006621

BP

protein retention in ER lumen

The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.

KDELR3, KDELR1, PDIA3, OS9

GO:0006622

BP

protein targeting to lysosome

The process of directing proteins towards the lysosome using signals contained within the protein.

RAB7A, SNX16, NCOA4, ZFYVE16, SORL1, NAGPA, AP3M1

GO:0006623

BP

protein targeting to vacuole

The process of directing proteins towards the vacuole, usually using signals contained within the protein.

GOSR2, VPS13C, PIK3R4, VTI1B

GO:0006625

BP

protein targeting to peroxisome

The process of directing proteins towards the peroxisome, usually using signals contained within the protein.

PEX12, ZFAND6, LONP2

GO:0006626

BP

protein targeting to mitochondrion

The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.

AIP, TIMM23, TIMM17B, MFN2, TOMM40, TSPO, BID, TOMM20, TOMM5, MGARP, DNAJC19, TRNT1, TIMM17A, MFF, TOMM22, TOMM7, TIMM10B

GO:0006627

BP

protein processing involved in protein targeting to mitochondrion

The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments.

PMPCA, MIPEP

GO:0006629

BP

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

PLPP1, PLPP3, TPP1, MGST3, PLIN1, ACSL4, SC5D, CH25H, LDLR, APOC1, APOD, CYP3A4, CLU, G6PD, PC, CD36, IL1RN, PTGS1, NR2F2, AOAH, CHKA, HMGCL, SREBF1, PPARG, LEP, ALDH3B2, PITPNB, FABP6, UCP3, PAFAH1B2, LRP2, PITPNA, FABP5, HMGCS1, OCRL, PPARD, PPARA, SREBF2, PDE3A, STARD3, ACOX1, PAFAH1B3, PLCL1, PLA1A, TECRL, SLC27A4, BTN2A1, NPHP3, LRP10, JAZF1, TPRA1, CNEP1R1, TRPV1, ABHD4, OMA1, FAR2, MGLL, HSD17B10, APOL2, ACAT2, OSBPL10, MID1IP1, GDE1, PEMT, PLCL2, LIPT1, LIPG, CEPT1

GO:0006631

BP

fatty acid metabolic process

The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.

NDUFS6, LYPLA1, LYPLA2, C3, FABP3, TH, GHR, PRKAR2B, SNCA, STAT5A, ACADSB, FASN, STAT5B, UCP3, CREM, PPARA, MSMO1, AASDH, THEM4, FA2H, GPAT4, AACS, ABHD5, ALKBH7, MECR, GPAM, PNPLA8, CROT, CRYL1

GO:0006633

BP

fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.

HACD1, ACACB, NDUFAB1, SC5D, CH25H, LPL, XBP1, ABCD3, BRCA1, FASN, PRKAG1, PRKAA2, MSMO1, ACSM3, HSD17B12, FA2H, MGLL, MECR, ELOVL4, PRKAG3

GO:0006635

BP

fatty acid beta-oxidation

A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).

SLC27A2, SLC25A17, ECI2, ABCD3, ECHS1, LEP, ECI1, ACADVL, CPT1A, HSD17B4, HADHB, SESN2, PPARD, ECH1, AUH, ADIPOQ, DECR1, HADH, HIBCH, ECHDC2, CPT1B, BDH2, ACAT2, CROT

GO:0006636

BP

unsaturated fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.

ELOVL7, SCD, FADS1, FADS2, SCD5, ELOVL1, ELOVL4, ELOVL6, ELOVL5

GO:0006637

BP

acyl-CoA metabolic process

The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.

ACOT8, HMGCL, GPAT4, ACOT4, GPAM, ACSL6, ACOT9

GO:0006638

BP

neutral lipid metabolic process

The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity.

SNCA

GO:0006641

BP

triglyceride metabolic process

The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.

INSIG1, ACSL4, APOE, APOA2, APOC1, APOC3, APOH, CYP2E1, LPL, GPX1, GK, ACSL1, G6PC, CPT1A, CAV1, PTPN11, APOBR, APOA5, PCSK9, LMF1, SEL1L

GO:0006642

BP

triglyceride mobilization

The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism.

APOB, LPIN1

GO:0006643

BP

membrane lipid metabolic process

The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.

B4GALT4

GO:0006644

BP

phospholipid metabolic process

The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.

PLPP1, PLPP3, APOA1, LPL, PLA2G2A, GPX4, SNCA, PLA2G5, NKX2-1, PLA2G4A, PLCD1, PLA2G16, PLPPR4, PCSK9, PLPP5, ABHD4, GATA6, PLPPR2, ACP6, LGALS13, PLA2G4C, PLAA

GO:0006646

BP

phosphatidylethanolamine biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.

ALOX15, CHKA, LPIN1, SLC27A1, PCYT2, EPT1, ETNK1, CHKB, CEPT1

GO:0006650

BP

glycerophospholipid metabolic process

The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.

GNPAT, PEMT

GO:0006651

BP

diacylglycerol biosynthetic process

The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.

ANG

GO:0006654

BP

phosphatidic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.

GNPAT, PLA2G2A, PLA2G5, PLA2G4A, PLD1, GPAT3, SLC27A1, LCLAT1, GPAT4, ABHD5, PLA2G12A, GPAM, AGPAT4, AGPAT3

GO:0006655

BP

phosphatidylglycerol biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.

CDS2, PGS1, SLC27A1, CDS1

GO:0006656

BP

phosphatidylcholine biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

APOA1, APOA2, CHKA, PCYT1A, FABP5, LPIN1, SLC27A1, GPAT4, SLC44A2, SLC44A3, SLC44A5, SLC44A1, PEMT, CHKB, PCYT1B, CEPT1

GO:0006657

BP

CDP-choline pathway

The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine.

CHKA, PCYT1A, CDS1, CHKB, PCYT1B, CEPT1

GO:0006658

BP

phosphatidylserine metabolic process

The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes.

SERINC3, PLA1A, SERINC5, SERINC2, SERINC1

GO:0006659

BP

phosphatidylserine biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.

PLSCR1, PTDSS1, SLC27A1