GO:0070097

MF

delta-catenin binding

Interacting selectively and non-covalently with the delta subunit of the catenin complex.

PTPRJ, DACT3, DACT1

GO:0070119

MF

ciliary neurotrophic factor binding

Interacting selectively and non-covalently with the cytokine ciliary neurotrophic factor.

IL6R

GO:0070123

MF

transforming growth factor beta receptor activity, type III

Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors.

TGFBR3

GO:0070139

MF

SUMO-specific endopeptidase activity

Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO.

SENP5

GO:0070180

MF

large ribosomal subunit rRNA binding

Interacting selectively and non-covalently with the large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA.

RPLP1, RPLP2, RPLP0, RPL19, MRTO4

GO:0070181

MF

small ribosomal subunit rRNA binding

Interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA.

RPS14, RPS13, CIRBP, UTP23

GO:0070182

MF

DNA polymerase binding

Interacting selectively and non-covalently with a DNA polymerase.

CDK2AP1, HMGB1, PCNA, SMARCA4, RAD51, ACD, FANCD2, FANCI, SMG5

GO:0070251

MF

pristanate-CoA ligase activity

Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA.

SLC27A2

GO:0070260

MF

5'-tyrosyl-DNA phosphodiesterase activity

Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA.

TDP2

GO:0070273

MF

phosphatidylinositol-4-phosphate binding

Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.

SH3PXD2B, SNX3, OSBP, ARFIP1, OSBPL8, PLEKHA5, SNX24

GO:0070290

MF

N-acylphosphatidylethanolamine-specific phospholipase D activity

Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).

PLD1, NAPEPLD

GO:0070300

MF

phosphatidic acid binding

Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.

PLCD1, UQCC3, COMMD1, RAPGEF6, MAPKAP1, ATP13A2, MARK1, PITPNC1

GO:0070320

MF

inward rectifier potassium channel inhibitor activity

Stops, prevents, or reduces the activity of an inwardly rectifying potassium channel.

CAV1

GO:0070324

MF

thyroid hormone binding

Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.

TTR, CTSH, THRA, ALDH1A3

GO:0070325

MF

lipoprotein particle receptor binding

Interacting selectively and non-covalently with a lipoprotein particle receptor.

APOA5

GO:0070326

MF

very-low-density lipoprotein particle receptor binding

Interacting selectively and non-covalently with a very-low-density lipoprotein receptor.

APOE, LRPAP1, PCSK9

GO:0070330

MF

aromatase activity

Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.

CYP1A1, CYP3A4, CYP2D6, CYP19A1, CYP3A5, CYP3A7, CYP1B1, CYP2U1, CYP3A43

GO:0070335

MF

aspartate binding

Interacting selectively and non-covalently with aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4.

CAD

GO:0070336

MF

flap-structured DNA binding

Interacting selectively and non-covalently with a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule.

FAN1

GO:0070363

MF

mitochondrial light strand promoter sense binding

Interacting selectively and non-covalently with the sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA.

TFAM

GO:0070401

MF

NADP+ binding

Interacting selectively and non-covalently with the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.

GMDS

GO:0070402

MF

NADPH binding

Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.

DHFR, HMGCR, QDPR, SRD5A1, FASN, CRYZ, DECR1, GRHPR

GO:0070403

MF

NAD+ binding

Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.

HPGD, ALDH1A3, HADH, SIRT2, UXS1, CRYL1

GO:0070404

MF

NADH binding

Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.

QDPR

GO:0070410

MF

co-SMAD binding

Interacting selectively and non-covalently with a common mediator SMAD signaling protein.

SMAD6, GATA4, SMAD3, SMAD2, SMAD1, CITED1, TRIM33

GO:0070411

MF

I-SMAD binding

Interacting selectively and non-covalently with an inhibitory SMAD signaling protein.

SMAD7, AXIN1, TGFB1I1, SMAD6, CTNNB1, TGFBR1, SMAD4, SMAD2, SMAD1

GO:0070412

MF

R-SMAD binding

Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.

SMAD6, FOS, JUN, PARP1, SMAD3, SMAD4, ANKRD1, SMAD2, ZC3H3, PMEPA1, RGCC, TRIM33

GO:0070463

MF

tubulin-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate.

KIF18A

GO:0070491

MF

repressing transcription factor binding

Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.

ARNTL, GMNN, MYC, EIF4E, HMGB1, SKI, SKIL, TCF3, NFYB, SRI, CTNNB1, CBX5, HDAC4, HHEX, RELA, HDAC1, RUNX2, HDAC7, DDX20, HDAC9, HDAC5, NOC2L

GO:0070492

MF

oligosaccharide binding

Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.

GYPC, SELE, DCBLD1, LOXL2

GO:0070506

MF

high-density lipoprotein particle receptor activity

Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis.

SCARB1

GO:0070513

MF

death domain binding

Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB.

DAPL1, DAP, CRADD, RIPK1, TRADD

GO:0070524

MF

11-beta-hydroxysteroid dehydrogenase (NADP+) activity

Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+.

HSD11B1

GO:0070530

MF

K63-linked polyubiquitin binding

Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers.

TNFAIP3, SQSTM1, OTUD7B, FAAP20, RNF169, ATRIP, OPTN, ZRANB1

GO:0070538

MF

oleic acid binding

Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid.

FABP3, SCP2

GO:0070539

MF

linoleic acid binding

Interacting selectively and non-covalently with linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid.

PPARD

GO:0070551

MF

endoribonuclease activity, cleaving siRNA-paired mRNA

Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters.

AGO2

GO:0070573

MF

metallodipeptidase activity

Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

ACE, CPQ

GO:0070576

MF

vitamin D 24-hydroxylase activity

Catalysis of the hydroxylation of C-24 of any form of vitamin D.

CYP1A1, CYP3A4

GO:0070577

MF

lysine-acetylated histone binding

Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation.

BRD4, BRD2, SMARCA4, PSME4, BRD3, CARM1, PHIP, BRD7, BAZ1B

GO:0070579

MF

methylcytosine dioxygenase activity

Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2.

ALKBH1

GO:0070611

MF

histone methyltransferase activity (H3-R2 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3.

PRMT6

GO:0070612

MF

histone methyltransferase activity (H2A-R3 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H2A.

PRMT6

GO:0070615

MF

nucleosome-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of one or more nucleosomes.

SMARCA1

GO:0070626

MF

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

ADSL

GO:0070628

MF

proteasome binding

Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation.

UBD, PSMG1, ID1, ADRM1, USP13, UCHL5

GO:0070644

MF

vitamin D response element binding

Interacting selectively and non-covalently with the vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum.

VDR, TCF3

GO:0070653

MF

high-density lipoprotein particle receptor binding

Interacting selectively and non-covalently with a high-density lipoprotein receptor.

APOA1, APOA2, APOC3

GO:0070679

MF

inositol 1,4,5 trisphosphate binding

Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate.

TRPC1, TRPC3, ITPR2, ITPR3, ITPR1, PLCL1, TRPC6

GO:0070698

MF

type I activin receptor binding

Interacting selectively and non-covalently with a type I activin receptor.

SMAD6

GO:0070699

MF

type II activin receptor binding

Interacting selectively and non-covalently with a type II activin receptor.

INHBA, SYNJ2BP, MAGI2

GO:0070700

MF

BMP receptor binding

Interacting selectively and non-covalently with a BMP receptor.

BMP2, BMP4, BMP3, BMP6, BMP8B, BMP8A, PYCARD

GO:0070717

MF

poly-purine tract binding

Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule.

TRA2B

GO:0070728

MF

leucine binding

Interacting selectively and non-covalently with 2-amino-4-methylpentanoic acid.

GLUD2, SESN2, UBR1, SESN1

GO:0070733

MF

protein adenylyltransferase activity

Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins.

FICD

GO:0070740

MF

tubulin-glutamic acid ligase activity

Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.

TTLL1

GO:0070742

MF

C2H2 zinc finger domain binding

Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.

WT1, HMGA2, EHMT2, SRRM2

GO:0070780

MF

dihydrosphingosine-1-phosphate phosphatase activity

Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate.

SGPP2

GO:0070815

MF

peptidyl-lysine 5-dioxygenase activity

Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2.

JMJD6

GO:0070840

MF

dynein complex binding

Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.

CCDC42B, TPR, HDAC6

GO:0070851

MF

growth factor receptor binding

Interacting selectively and non-covalently with a growth factor receptor.

APP, FYN

GO:0070856

MF

myosin VI light chain binding

Interacting selectively and non-covalently with a light chain of a myosin VI complex.

IQGAP3

GO:0070878

MF

primary miRNA binding

Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.

SMAD1, EZH2

GO:0070883

MF

pre-miRNA binding

Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA.

DICER1

GO:0070888

MF

E-box binding

Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.

ARNTL, BHLHE40, PER1, TCF21, MYC, TCF4, TCF3, TAL1, LMO2, AHR, ZEB1, ASCL1, SREBF2, TWIST1, ARNTL2, ATOH8, TCF12

GO:0070890

MF

sodium-dependent L-ascorbate transmembrane transporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in).

SLC23A2

GO:0070891

MF

lipoteichoic acid binding

Interacting selectively and non-covalently with lipoteichoic acid.

CD14, CD6

GO:0070892

MF

lipoteichoic acid receptor activity

Combining with lipoteichoic acid and transmitting the signal to initiate a change in cell activity.

CD36

GO:0070905

MF

serine binding

Interacting selectively and non-covalently with 2-amino-3-hydroxypropanoic acid.

SHMT1, THNSL2

GO:0070974

MF

POU domain binding

Interacting selectively and non-covalently with a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors.

AR

GO:0070975

MF

FHA domain binding

Interacting selectively and non-covalently with a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich.

MDC1

GO:0070984

MF

SET domain binding

Interacting selectively and non-covalently with a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation.

WIZ

GO:0070990

MF

snRNP binding

Interacting selectively and non-covalently with any part of a small nuclear ribonucleoprotein particle.

PRPF31

GO:0070996

MF

type 1 melanocortin receptor binding

Interacting selectively and non-covalently with a type 1 melanocortin receptor.

POMC, MRAP, MRAP2

GO:0071074

MF

eukaryotic initiation factor eIF2 binding

Interacting selectively and non-covalently with eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation.

EIF5

GO:0071207

MF

histone pre-mRNA stem-loop binding

Interacting selectively and non-covalently with a conserved stem-loop structure found in histone pre-mRNAs.

SLBP

GO:0071208

MF

histone pre-mRNA DCP binding

Interacting selectively and non-covalently with the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing.

SNRPB, SNRPD3, SLBP

GO:0071209

MF

U7 snRNA binding

Interacting selectively and non-covalently with the U7 small nuclear RNA (U7 snRNA).

SNRPD3

GO:0071253

MF

connexin binding

Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions.

GJA1, GJA5, CXADR, CNST

GO:0071424

MF

rRNA (cytosine-N4-)-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine.

METTL15

GO:0071532

MF

ankyrin repeat binding

Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure.

RELA

GO:0071535

MF

RING-like zinc finger domain binding

Interacting selectively and non-covalently with a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain.

UBE2I

GO:0071558

MF

histone demethylase activity (H3-K27 specific)

Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.

UTY, KDM6A, KDM7A

GO:0071566

MF

UFM1 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond.

UBA5

GO:0071567

MF

UFM1 hydrolase activity

Catalysis of the hydrolysis of UFM1, a small ubiquitin-related modifier, from previously modified substrates.

UFSP2

GO:0071723

MF

lipopeptide binding

Interacting selectively and non-covalently with a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids.

CD1D, TLR1

GO:0071813

MF

lipoprotein particle binding

Interacting selectively and non-covalently with a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.

APOE, MAPT, CD36, CDH13

GO:0071820

MF

N-box binding

Interacting selectively and non-covalently with an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses.

HES1

GO:0071837

MF

HMG box domain binding

Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin.

HOXA3, JUN, HOXC4, EGR2, MEOX1, DLX5, HHEX, MEF2C, TCF12

GO:0071862

MF

protein phosphatase type 1 activator activity

Increases the activity of the enzyme protein phosphatase type 1.

PPP1R15A, PHACTR4

GO:0071884

MF

vitamin D receptor activator activity

Interacting (directly or indirectly) with vitamin D receptors such that the proportion of receptors in the active form is increased.

BAZ1B

GO:0071886

MF

1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Interacting selectively and non-covalently with the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug.

HTR2C

GO:0071889

MF

14-3-3 protein binding

Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.

PPP1R12A, ZFP36, AKT1, SIK1, SRPK2, ZFP36L1, HDAC7, BAD, KIF13B, DDIT4, PI4KB, SYNPO2, IRS2

GO:0071933

MF

Arp2/3 complex binding

Interacting selectively and non-covalently with an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5).

IQGAP2, CORO1B, SNX9

GO:0071936

MF

coreceptor activity involved in Wnt signaling pathway

In cooperation with a primary Wnt receptor, initiating a change in cell activity through the Wnt signaling pathway.

LRP5, LRP6

GO:0071949

MF

FAD binding

Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

AGPS, KMO, PRODH, MICAL2, AIFM1, MICAL1

GO:0071987

MF

WD40-repeat domain binding

Interacting selectively and non-covalently with a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain.

CCT6A, CDC5L

GO:0072320

MF

volume-sensitive chloride channel activity

Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.

CLCN3, TTYH1

GO:0072341

MF

modified amino acid binding

Interacting selectively and non-covalently with a modified amino acid.

CBS, MTHFR, NOX4

GO:0072345

MF

NAADP-sensitive calcium-release channel activity

Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts.

TPCN2