GO:0050656

MF

3'-phosphoadenosine 5'-phosphosulfate binding

Interacting selectively and non-covalently with 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.

ENPP1, CHST15

GO:0050659

MF

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

CHST15, CHST11

GO:0050660

MF

flavin adenine dinucleotide binding

Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.

KMO, ACOX3, KDM1A, DUS4L, CYB5R3, GSR, CYBB, DLD, MAOB, NOS3, SDHA, FMO4, MTHFR, ACADSB, XDH, ACADVL, GFER, AOX1, DPYD, SQLE, ACOX1, DHCR24, ETFDH, TXNRD1, NOX5, ACOX2, FMO2, AIFM2, NOX4

GO:0050661

MF

NADP binding

Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

IDH1, TM7SF2, H6PD, CRYZL1, GSR, GAPDH, G6PD, NOS3, FMO4, MTHFR, DPYD, NOX5, FMO2, DUOX1, DHCR7

GO:0050662

MF

coenzyme binding

Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

HMGCR, GCLC

GO:0050681

MF

androgen receptor binding

Interacting selectively and non-covalently with an androgen receptor.

TGFB1I1, TCF21, KDM1A, PRKCB, RB1, DDX5, CALR, CTNNB1, BRCA1, NRIP1, CDK7, SMARCA4, EP300, NCOA4, NCOA1, PKN1, WIPI1, FOXP1, PPARGC1A, RNF14, RNF6, NCOA3

GO:0050682

MF

AF-2 domain binding

Interacting selectively and non-covalently with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation.

PPARGC1B

GO:0050683

MF

AF-1 domain binding

Interacting selectively and non-covalently with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor.

HEYL

GO:0050692

MF

DBD domain binding

Interacting selectively and non-covalently with the DBD, DNA binding domain, of a protein. The DNA binding domain of the vitamin D receptor, one of a family of receptors with the DBD, is split into three regions, the P, D and T boxes. Residues that are critical for target sequence selectivity form the P-box. The D-box contains residues that are important for homodimerization of class I nuclear receptors. The T-box is essential for both DNA-binding and transactivation of the VDR; this region may also be important for dimerization with RXR for class II nuclear receptors.

PROX1

GO:0050693

MF

LBD domain binding

Interacting selectively and non-covalently with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket.

PROX1, CITED1, CITED2

GO:0050699

MF

WW domain binding

Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.

CDC25C, SCNN1A, SCNN1G, TNK2, TCEAL1, ENAH, TCEAL3, PMEPA1, TCEAL4, KIF20B, LITAF, NDFIP2

GO:0050700

MF

CARD domain binding

Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.

RIPK2, MAVS, CARD19

GO:0050733

MF

RS domain binding

Interacting selectively and non-covalently with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing.

SRSF10, SON, SRSF1, SRSF5, LUC7L

GO:0050750

MF

low-density lipoprotein particle receptor binding

Interacting selectively and non-covalently with a low-density lipoprotein receptor.

DKK1, APOE, CRP, APOB, HSP90B1, SYT1, LRPAP1, DNAJA1, LDLRAP1, APOA5, PCSK9, AP2M1

GO:0050780

MF

dopamine receptor binding

Interacting selectively and non-covalently with a dopamine receptor.

CLIC6

GO:0050786

MF

RAGE receptor binding

Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products.

S100B, S100A8, S100A9, HMGB1, FPR1, S100P, S100A4, HMGB2, S100A7, S100A13

GO:0050811

MF

GABA receptor binding

Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.

TRAK2, GABRA5, GABARAPL2, PLCL1, GABARAPL1, PLCL2, TRAK1, ARFGEF2

GO:0050815

MF

phosphoserine binding

Interacting selectively and non-covalently with a phosphorylated serine residue within a protein.

YWHAB, YWHAE

GO:0050833

MF

pyruvate transmembrane transporter activity

Enables the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other.

SLC16A7

GO:0050839

MF

cell adhesion molecule binding

Interacting selectively and non-covalently with a cell adhesion molecule.

FGA, FGB, FGG, ITGB3, ITGB2, ITGB1, SELL, JUP, PVR, EZR, CD1D, DSP, CPE, VCAM1, PTPRD, CD200, CXADR, ADAM8, PTPN11, SMAGP, DSG2, POSTN, NECTIN1, TENM4, NLGN4X, NLGN1, CADM1, CDHR2, NECTIN3, TENM3, NRXN1, PKP3

GO:0050840

MF

extracellular matrix binding

Interacting selectively and non-covalently with a component of the extracellular matrix.

CYR61, VTN, ITGB3, ITGAV, DCN, SPARC, SPP1, COL11A1, VEGFA, BGN, FBLN2, SPARCL1, TGFBI, OLFML2A, GPR126, ADAMTS15, SPOCK2, CD248, ADAMTS5, ADGRG1

GO:0050897

MF

cobalt ion binding

Interacting selectively and non-covalently with a cobalt (Co) ion.

NUDT16

GO:0050998

MF

nitric-oxide synthase binding

Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.

CD74, DMD, ATP2B4, ACTB, CALM2, CAV1, SNTA1, CAMK2D

GO:0051010

MF

microtubule plus-end binding

Interacting selectively and non-covalently with the plus end of a microtubule.

APC, CLIP1, DST, MAPRE1, KIF18A, KIF2C, CLIP2

GO:0051011

MF

microtubule minus-end binding

Interacting selectively and non-covalently with the minus end of a microtubule.

CAMSAP2, TUBGCP3, CAMSAP3

GO:0051015

MF

actin filament binding

Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

WIPF3, BIN1, ARPC2, ARPC3, ACTN4, WDR1, NEBL, MYO1D, EGFR, ACTN1, MYL4, EEF2, LCP1, EZR, FLNA, CFL1, CTNNA2, TMOD1, SSFA2, MARCKS, CORO1A, CTNNA1, MYH9, ACTN2, MYH11, ABL2, CAPZB, ARPC4, DSTN, ACTR3, ACTR2, NEXN, MYO1E, IQGAP2, SHROOM2, FLNC, PLS1, FSCN1, CYFIP1, ADSSL1, SHROOM3, SYNE2, TTN, CORO2A, AJUBA, PANX1, AIF1L, CORO1B, TRIOBP, TRPV4, MYO10, CTNNAL1, LIMA1, BLOC1S6, CORO1C, MYO6, MACF1, TLN1

GO:0051018

MF

protein kinase A binding

Interacting selectively and non-covalently with any subunit of protein kinase A.

RDX, AKAP13, AKAP6, SPHKAP, MYRIP, DACT3, DACT1, AKAP7, AKAP11, AKAP2

GO:0051019

MF

mitogen-activated protein kinase binding

Interacting selectively and non-covalently with a mitogen-activated protein kinase.

TPR, ACE, ATF7, PTAFR, IQGAP1, GTF2I, DUSP2, PTPRJ, MAPK7, NBR1

GO:0051020

MF

GTPase binding

Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.

ENO1, EPRS, HSP90AA1, LCP1, GNB3, RASA1, FLNA, GNB1, GNB2, YBX1, SPTBN1, BNIP3, GOLGA4

GO:0051022

MF

Rho GDP-dissociation inhibitor binding

Interacting selectively and non-covalently with a Rho GDP-dissociation inhibitor protein.

HSP90AA1, CDC42, RAC1

GO:0051033

MF

RNA transmembrane transporter activity

Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other.

HNRNPA3

GO:0051059

MF

NF-kappaB binding

Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.

HDAC3, BCL10, NPM1, ANXA4, GSK3B, PPARD, RELA, HDAC1, TP53BP2, COMMD6, MTDH, SETD6, HDAC2, FOXP3, FAF1

GO:0051082

MF

unfolded protein binding

Interacting selectively and non-covalently with an unfolded protein.

AIP, TOR1A, CLGN, PFDN6, DNAJA2, DNAJB6, SRSF10, RP2, CLPX, CRYAB, APCS, SCG5, NPM1, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPD1, HSPA5, HSP90B1, HSPA6, TCP1, PPIB, DNAJB1, DNAJB2, CALR, CANX, LRPAP1, DNAJA1, HSPA1L, CCT6A, CCT3, SERPINH1, CCT8, HSPE1, PPIA, TUBB4B, CCT2, CHAF1A, CHAF1B, CLN3, PTGES3, TOMM20, CDC37, SYVN1, ERO1B, NUDCD2, DNAJA4, PFDN5, TTC1, NAP1L4, CCT7, GRPEL1, DNAJC4, MKKS, PFDN4, MDN1, UGGT1, DNAJB4, RUVBL2

GO:0051087

MF

chaperone binding

Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.

PFDN6, BIRC5, SLC25A17, PARK2, DNAJA2, DNAJB6, BAG2, FGB, ALB, PRNP, VWF, TP53, HSPD1, CLU, HSPA5, DNAJB1, DNAJB2, CALR, ERP29, DNAJA1, STIP1, CDKN1B, ATP1A2, CTSC, HSPE1, OGDH, DNAJC3, HES1, CDC37, AHSA2, SYVN1, DNAJC10, DNAJA4, USP13, DNAJC1, PACRG, TBCD, GRPEL1, PFDN4, DNAJB4, AMFR, BAG5, HYOU1

GO:0051117

MF

ATPase binding

Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.

ATP6V1G1, UBE4B, ABCA1, ESR1, ATP1B1, PGR, AR, RALA, RALB, EZR, DNAJB1, PLN, RDX, ATXN3, ATP1B3, NR1H2, SNU13, FXYD4, GABARAPL2, ANK2, CAV1, PDE4D, SNTA1, TCIRG1, PKD2, NKAIN1, SYVN1, DNAJC10, SVIP, METTL21A, UFD1L, ATP6V0A1, VIMP, BBC3, NUFIP1, USP25, NSFL1C, TRPC6

GO:0051120

MF

hepoxilin A3 synthase activity

Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3.

ALOX15

GO:0051139

MF

metal ion:proton antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in).

SLC11A1

GO:0051183

MF

vitamin transporter activity

Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

GC

GO:0051213

MF

dioxygenase activity

Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products.

UTY, KDM6A, KDM4B, PTGS1, JMJD1C, ASPHD1, ASPHD2, OGFOD3, ALKBH7

GO:0051219

MF

phosphoprotein binding

Interacting selectively and non-covalently with a phosphorylated protein.

MID1, TOX3, URI1, PLAT, RB1, LYN, IGF2R, PRKCSH, YWHAB, SFN, SNCA, YWHAE, FKBP4, PKD2, TRPV1, TBK1, THRAP3, TBL2

GO:0051264

MF

mono-olein transacylation activity

Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol.

PNPLA3

GO:0051265

MF

diolein transacylation activity

Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein.

PNPLA3

GO:0051267

MF

CP2 mannose-ethanolamine phosphotransferase activity

Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2.

PIGG

GO:0051287

MF

NAD binding

Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.

PHGDH, IDH3B, UGDH, NDUFS2, IDH1, LDHA, CYB5R3, GAPDH, LDHB, DLD, PARP1, HPGD, ME2, AHCY, HIBADH, MDH1, IDH2, CTBP2, HSD11B2, SORD, AOX1, ME3, GLYR1, BDH2, GRHPR

GO:0051371

MF

muscle alpha-actinin binding

Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.

LDB3, PKD2, PALLD, TTN, PDLIM2, SYNPO2

GO:0051373

MF

FATZ binding

Interacting selectively and non-covalently with a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components.

ACTN2, MYOZ1

GO:0051378

MF

serotonin binding

Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.

HTR2C, HTR2B

GO:0051379

MF

epinephrine binding

Interacting selectively and non-covalently with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.

ADRB2, ADRB1, ADRB3, ADRA2B

GO:0051380

MF

norepinephrine binding

Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.

ADRB2, ADRB1, ADRB3

GO:0051393

MF

alpha-actinin binding

Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.

PPARG, CACNA1C, DAG1, MAGI1, MYOT

GO:0051400

MF

BH domain binding

Interacting selectively and non-covalently with the Bcl-2 homology (BH) domain of a protein. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains.

BCL2L2, BOK

GO:0051425

MF

PTB domain binding

Interacting selectively and non-covalently with a phosphotyrosine-binding (PTB) domain of a protein.

APP, INSR, NUP62, INPP5D

GO:0051428

MF

peptide hormone receptor binding

Interacting selectively and non-covalently with a receptor for peptide hormones.

JAK2, PTH, FYN, PTHLH, LEP, PTPN11

GO:0051430

MF

corticotropin-releasing hormone receptor 1 binding

Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.

GNAS, GNAS

GO:0051434

MF

BH3 domain binding

Interacting selectively and non-covalently with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death.

BCL2, BAX, MCL1

GO:0051500

MF

D-tyrosyl-tRNA(Tyr) deacylase activity

Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA.

DTD2

GO:0051525

MF

NFAT protein binding

Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.

GATA4, PPARA, MAPK14, FOXP3

GO:0051536

MF

iron-sulfur cluster binding

Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms.

ABAT, FXN, ELP3

GO:0051537

MF

2 iron, 2 sulfur cluster binding

Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.

FDX1, NDUFV2, SDHB, NDUFS1, UQCRFS1, XDH, AOX1, FXN, FDX1L, CISD2, ISCA1, GLRX2, CISD1

GO:0051538

MF

3 iron, 4 sulfur cluster binding

Interacting selectively and non-covalently with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing.

SDHB, ACO2

GO:0051539

MF

4 iron, 4 sulfur cluster binding

Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.

NDUFS8, REV3L, NDUFS2, POLA1, ERCC2, SDHB, NDUFS1, POLD1, PRIM2, DNA2, NTHL1, PPAT, POLE, DPYD, ETFDH, CDKAL1, NUBPL, ACO2, ISCA1, MUTYH, NFU1

GO:0051575

MF

5'-deoxyribose-5-phosphate lyase activity

Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site.

POLQ, XRCC5, HMGA2

GO:0051717

MF

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.

PTEN, MINPP1

GO:0051718

MF

DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates

Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA).

DNMT3B

GO:0051721

MF

protein phosphatase 2A binding

Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.

ENSA, HMGCR, TP53, BCL2, AKT1, ARPP19, IGBP1, FOXO1, STRN3, EIF4EBP1, PPP2R4, ANKLE2, MASTL, STRN4, SPHK1, CTTNBP2NL, SMG5, PPME1

GO:0051722

MF

protein C-terminal methylesterase activity

Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol.

PPME1

GO:0051724

MF

NAD transporter activity

Enables the directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH.

SLC25A17

GO:0051787

MF

misfolded protein binding

Interacting selectively and non-covalently with a misfolded protein.

TOR1A, HSPD1, CLU, HSPA5, DNAJC3, DNAJC10, EDEM1, HDAC6, DNAJB9, STUB1

GO:0051800

MF

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol-4-phosphate + phosphate.

PTEN

GO:0051861

MF

glycolipid binding

Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate.

GLTP

GO:0051864

MF

histone demethylase activity (H3-K36 specific)

Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein.

KDM7A, KDM2A

GO:0051870

MF

methotrexate binding

Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

DHFR, FOLR1

GO:0051879

MF

Hsp90 protein binding

Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.

ARNTL, ERN1, GBP1, AHR, NUP62, NASP, PPID, KPNB1, CDC37, HIF1A, PACRG, NPAS2, HDAC8, HDAC6, CHORDC1, STUB1

GO:0051880

MF

G-quadruplex DNA binding

Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome.

BLM, RAD50, DHX36, PIF1

GO:0051908

MF

double-stranded DNA 5'-3' exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule.

EXO1

GO:0051920

MF

peroxiredoxin activity

Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

PRDX6, SESN1

GO:0051959

MF

dynein light intermediate chain binding

Interacting selectively and non-covalently with a light intermediate chain of the dynein complex.

RAB11FIP3, DYNC1H1, BICD2

GO:0051978

MF

lysophospholipid transporter activity

Enables the directed movement of lysophospholipids into, out of or within a cell, or between cells. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids.

MFSD2A

GO:0051990

MF

(R)-2-hydroxyglutarate dehydrogenase activity

Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.

IDH1

GO:0051996

MF

squalene synthase activity

Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate.

FDFT1

GO:0052591

MF

sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity

Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8.

GPD2

GO:0052593

MF

tryptamine:oxygen oxidoreductase (deaminating) activity

Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+.

AOC2, AOC3

GO:0052594

MF

aminoacetone:oxygen oxidoreductase(deaminating) activity

Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+.

AOC2, AOC3

GO:0052595

MF

aliphatic-amine oxidase activity

Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+.

AOC2, AOC3

GO:0052596

MF

phenethylamine:oxygen oxidoreductase (deaminating) activity

Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+.

AOC2, AOC3

GO:0052629

MF

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.

SYNJ2, SYNJ1, MTM1, MTMR1, MTMR2, MTMR4

GO:0052642

MF

lysophosphatidic acid phosphatase activity

Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol.

ACPP, ACP6

GO:0052650

MF

NADP-retinol dehydrogenase activity

Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.

DHRS3, AKR1C3, RDH10, RDH13, RDH11, DHRS4

GO:0052654

MF

L-leucine transaminase activity

Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid.

BCAT1

GO:0052655

MF

L-valine transaminase activity

Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid.

BCAT1

GO:0052656

MF

L-isoleucine transaminase activity

Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.

BCAT1

GO:0052658

MF

inositol-1,4,5-trisphosphate 5-phosphatase activity

Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.

SYNJ1, OCRL, INPP5A, INPP5K

GO:0052659

MF

inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.

SYNJ1, OCRL, ITPK1, INPP5A, INPP5D, INPP5K

GO:0052689

MF

carboxylic ester hydrolase activity

Catalysis of the hydrolysis of a carboxylic ester bond.

ACOT7, ACOT8, LYPLA2, CES3, NLGN4X, NLGN1, ACOT4, ABHD4, ABHD5, LIPH, FAM135A, ACOT9

GO:0052723

MF

inositol hexakisphosphate 1-kinase activity

Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate.

PPIP5K1, IP6K2

GO:0052724

MF

inositol hexakisphosphate 3-kinase activity

Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate.

PPIP5K1, IP6K2

GO:0052725

MF

inositol-1,3,4-trisphosphate 6-kinase activity

Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+).

ITPK1

GO:0052726

MF

inositol-1,3,4-trisphosphate 5-kinase activity

Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).

ITPK1

GO:0052739

MF

phosphatidylserine 1-acylhydrolase activity

Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid.

PLA2G16

GO:0052740

MF

1-acyl-2-lysophosphatidylserine acylhydrolase activity

Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate.

PLA2G16